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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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T
A
A
C
A
C
C
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G
A
A
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G
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C
A
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C
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G
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A
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A
T
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4,749
C
T
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C
C
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G
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A
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T
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T
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T
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1
4,750
C
T
C
C
C
T
T
G
T
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G
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C
C
A
A
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A
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A
A
G
T
T
T
T
T
A
T
A
T
A
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T
T
T
T
G
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T
A
A
G
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1
4,751
C
T
C
C
C
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C
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A
T
T
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A
G
A
G
T
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A
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G
T
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A
C
T
T
A
C
C
T
T
C
T
G
T
C
A
A
A
A
T
C
T
G
T
T
T
C
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A
G
A
A
A
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C
T
G
T
T
T
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1
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G
C
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C
A
C
C
T
C
A
G
G
G
G
C
G
A
T
A
T
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G
G
G
G
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G
C
C
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C
A
G
A
A
G
G
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C
T
G
G
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T
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C
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A
T
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1
4,753
C
C
T
T
C
C
C
A
C
T
C
T
C
T
T
C
C
T
C
A
C
A
G
A
T
A
G
C
C
A
C
C
C
G
C
A
A
G
G
C
C
T
A
C
G
G
G
C
A
G
G
C
A
C
T
G
G
C
C
A
A
G
C
T
G
T
0.031311
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0.068493
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0.009785
0.027397
1
4,754
A
C
A
C
G
G
A
T
C
C
G
A
C
T
G
C
T
T
A
C
C
C
A
C
T
A
A
G
G
A
C
A
C
C
A
A
G
A
A
C
C
A
G
G
T
T
A
A
G
G
A
C
G
A
A
A
A
A
T
G
A
G
C
C
A
T
0.07045
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1
4,755
T
C
A
C
T
T
T
G
A
A
G
A
T
T
C
T
T
A
A
G
A
G
G
C
G
C
A
C
A
C
A
C
C
G
A
A
A
C
A
C
A
G
A
G
A
T
C
C
C
C
A
G
G
G
G
A
G
A
C
A
T
G
A
T
T
G
0.041096
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1
4,756
A
G
G
A
C
C
T
G
C
C
G
C
G
G
G
A
C
T
G
G
C
T
C
T
G
G
G
G
C
G
G
C
T
G
C
G
G
C
G
A
C
A
A
C
A
T
C
G
A
C
T
A
T
G
G
C
T
A
C
C
G
C
T
T
T
C
0.003914
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0.080235
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0.011742
0
0.021526
1
4,757
C
G
C
C
T
T
C
T
C
C
G
A
T
G
T
A
C
T
G
C
A
T
G
T
G
G
T
C
C
T
G
A
T
A
C
A
A
G
T
G
G
C
A
C
A
G
T
T
T
C
T
T
C
T
G
T
C
C
T
T
G
A
G
A
A
C
0.07045
0.021526
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0.043053
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0.027397
0.035225
1
4,758
C
G
A
T
G
T
A
C
T
G
C
A
T
G
T
G
G
T
C
C
T
G
A
T
A
C
A
A
G
T
G
G
C
A
C
A
G
T
T
T
C
T
T
C
T
G
T
C
C
T
T
G
A
G
A
A
A
G
T
C
C
T
G
C
C
G
0.07045
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0.029354
0.043053
0.017613
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0.033268
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0.027397
0.037182
1
4,759
T
C
T
G
T
C
C
T
T
G
A
G
A
A
A
G
T
C
C
T
G
C
C
A
G
T
T
G
G
C
T
G
C
A
G
A
G
A
G
G
C
T
G
T
G
C
T
C
C
T
A
T
A
A
T
A
T
A
T
A
C
T
T
C
T
A
0.080235
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0.033268
1
4,760
C
T
T
C
C
A
T
C
C
T
C
C
T
C
C
A
C
T
G
C
G
C
T
A
C
C
G
G
G
A
G
C
C
A
G
T
C
T
T
G
G
A
G
A
A
A
T
T
T
G
A
T
T
C
G
G
G
C
T
T
G
G
T
T
T
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0.060665
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0.027397
1
4,761
T
G
C
C
G
A
A
A
A
G
C
T
C
C
G
C
C
A
G
G
C
C
A
A
G
C
A
G
A
G
T
T
C
G
T
C
C
G
C
G
G
C
G
C
T
C
A
G
C
A
A
G
T
T
T
A
T
C
G
C
C
G
T
C
T
T
0.02544
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1
4,762
G
T
G
A
T
T
C
T
C
T
A
T
G
G
G
A
C
C
T
T
T
T
C
A
G
T
T
T
T
G
C
A
C
G
C
C
G
A
T
T
T
T
G
A
A
A
C
C
A
A
A
T
C
T
A
A
A
G
T
T
A
A
G
G
A
T
0.133072
0.033268
0.031311
0.091977
0.037182
0.011742
0.001957
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0.058708
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0.062622
0.013699
0.021526
0.005871
0.017613
0.015656
0.060665
0.041096
1
4,763
T
T
C
C
T
T
A
A
C
T
T
T
A
G
A
T
T
T
G
G
T
T
T
C
A
A
A
A
T
C
G
G
C
G
T
G
C
A
A
A
A
C
T
G
A
A
A
A
G
G
T
C
C
C
A
T
A
G
A
G
A
A
T
C
A
T
0.135029
0.033268
0.031311
0.091977
0.037182
0.011742
0.001957
0.029354
0.058708
0.011742
0.013699
0.060665
0.033268
0.037182
0.035225
0.017613
0.029354
0.019569
0.003914
0.001957
0.007828
0.003914
0.039139
0.015656
0.062622
0.013699
0.021526
0.005871
0.017613
0.015656
0.060665
0.041096
1
4,764
A
C
T
A
A
A
T
T
T
G
A
A
A
A
T
T
A
C
C
T
G
G
A
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C
T
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C
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G
A
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C
A
A
T
T
T
T
T
G
A
G
C
T
A
A
G
T
C
T
T
C
T
C
T
0.133072
0.033268
0.035225
0.09589
0.031311
0.013699
0.001957
0.029354
0.062622
0.015656
0.017613
0.039139
0.035225
0.037182
0.035225
0.009785
0.027397
0.021526
0.001957
0.001957
0.007828
0.003914
0.043053
0.019569
0.056751
0.015656
0.017613
0.009785
0.017613
0.017613
0.072407
0.039139
1
4,765
A
C
C
C
T
C
A
A
C
T
T
G
C
T
C
C
T
T
T
T
C
A
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G
A
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A
C
T
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A
C
C
A
G
A
A
G
A
A
A
G
A
C
T
G
T
G
T
T
C
C
0.074364
0.031311
0.037182
0.056751
0.043053
0.015656
0.009785
0.02544
0.050881
0.043053
0.037182
0.029354
0.013699
0.021526
0.033268
0.02544
0.058708
0.033268
0.033268
0.003914
0.003914
0.005871
0.023483
0.037182
0.037182
0.027397
0.031311
0.029354
0.029354
0.009785
0.054795
0.033268
1
4,766
A
T
C
A
A
G
C
A
A
A
A
T
A
A
A
A
T
A
A
A
C
G
T
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A
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C
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G
A
A
A
A
C
T
G
T
T
G
C
A
A
T
G
T
A
G
A
G
C
T
0.109589
0.043053
0.048924
0.076321
0.04501
0.015656
0.009785
0.031311
0.033268
0.035225
0.015656
0.050881
0.021526
0.046967
0.041096
0.015656
0.02544
0.021526
0.005871
0.001957
0
0.003914
0.019569
0.021526
0.039139
0.017613
0.019569
0.003914
0.019569
0.02544
0.088063
0.046967
1
4,767
C
C
C
A
T
C
A
C
C
A
A
C
T
T
T
A
A
C
C
A
G
A
A
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T
G
G
C
A
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A
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G
G
G
A
G
C
C
C
T
G
G
T
A
G
A
C
A
G
C
T
G
G
0.035225
0.02544
0.046967
0.019569
0.033268
0.033268
0.011742
0.017613
0.04501
0.046967
0.037182
0.021526
0.041096
0.043053
0.037182
0.033268
0.050881
0.074364
0.054795
0.005871
0
0.005871
0.023483
0.02544
0.031311
0.019569
0.031311
0.037182
0.046967
0.017613
0.023483
0.023483
1
4,768
C
T
T
T
A
A
C
C
A
G
A
A
C
T
G
G
C
A
A
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A
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A
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C
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G
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A
G
A
C
A
G
C
T
G
T
G
C
T
C
C
A
G
G
T
A
G
0.035225
0.02544
0.046967
0.019569
0.029354
0.031311
0.011742
0.019569
0.046967
0.046967
0.037182
0.021526
0.041096
0.043053
0.039139
0.029354
0.050881
0.074364
0.054795
0.005871
0
0.005871
0.023483
0.027397
0.031311
0.021526
0.031311
0.037182
0.046967
0.015656
0.021526
0.027397
1
4,769
C
C
A
C
T
T
A
C
C
T
G
G
A
G
C
A
C
A
G
C
T
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G
C
C
G
T
C
T
T
G
C
C
A
G
T
T
C
T
G
G
T
T
0.037182
0.02544
0.046967
0.019569
0.029354
0.031311
0.011742
0.019569
0.046967
0.046967
0.037182
0.023483
0.041096
0.043053
0.037182
0.029354
0.050881
0.072407
0.052838
0.005871
0
0.005871
0.023483
0.027397
0.031311
0.021526
0.031311
0.037182
0.046967
0.015656
0.023483
0.027397
1
4,770
C
C
A
G
A
A
C
T
G
G
C
A
A
G
A
C
G
G
C
A
A
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C
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G
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C
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C
T
G
T
G
C
T
C
C
A
G
G
T
A
A
G
T
G
G
C
T
0.037182
0.02544
0.046967
0.019569
0.029354
0.031311
0.011742
0.019569
0.046967
0.046967
0.035225
0.023483
0.043053
0.043053
0.037182
0.029354
0.050881
0.072407
0.052838
0.005871
0
0.005871
0.023483
0.027397
0.031311
0.021526
0.031311
0.037182
0.046967
0.015656
0.023483
0.027397
1
4,771
T
G
G
G
A
C
A
C
C
C
A
G
C
C
A
G
T
C
A
T
C
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G
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C
A
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C
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C
A
T
T
A
T
C
C
A
C
A
G
G
C
T
T
C
T
G
C
G
C
0.054795
0.02544
0.033268
0.035225
0.041096
0.033268
0.001957
0.027397
0.050881
0.029354
0.043053
0.029354
0.035225
0.043053
0.021526
0.043053
0.056751
0.039139
0.033268
0.007828
0.003914
0.001957
0.029354
0.031311
0.031311
0.021526
0.046967
0.031311
0.02544
0.013699
0.041096
0.037182
1
4,772
G
C
A
T
A
C
C
T
G
T
G
G
G
A
C
A
C
C
C
A
G
C
C
A
G
T
C
A
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C
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G
C
C
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G
C
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C
A
T
G
G
C
T
T
C
T
C
G
T
G
C
A
T
T
A
T
C
C
A
C
A
G
A
0.058708
0.02544
0.033268
0.039139
0.041096
0.033268
0.001957
0.027397
0.052838
0.029354
0.041096
0.027397
0.033268
0.041096
0.021526
0.043053
0.058708
0.039139
0.033268
0.007828
0.003914
0.001957
0.027397
0.029354
0.033268
0.021526
0.046967
0.031311
0.023483
0.013699
0.041096
0.037182
1
4,773
G
A
A
C
T
G
G
G
A
C
A
G
G
T
A
A
G
T
C
A
T
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A
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A
G
T
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C
T
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C
A
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A
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C
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G
G
T
G
A
A
T
G
A
T
T
T
C
T
T
C
A
G
G
A
G
T
0.060665
0.037182
0.04501
0.041096
0.041096
0.035225
0.001957
0.033268
0.041096
0.029354
0.035225
0.021526
0.02544
0.037182
0.052838
0.041096
0.027397
0.043053
0.037182
0.009785
0.003914
0
0.019569
0.046967
0.035225
0.021526
0.021526
0.023483
0.029354
0.011742
0.035225
0.054795
1
4,774
A
T
G
T
G
G
A
C
G
A
G
C
A
C
T
C
A
G
T
T
A
T
G
A
C
T
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C
C
T
G
T
C
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C
A
G
T
T
C
C
C
C
A
A
A
G
C
C
A
A
G
C
T
C
A
A
G
C
C
G
G
G
G
C
0.062622
0.041096
0.043053
0.043053
0.04501
0.035225
0.001957
0.035225
0.041096
0.02544
0.033268
0.02544
0.02544
0.039139
0.052838
0.041096
0.031311
0.041096
0.029354
0.009785
0.003914
0
0.015656
0.043053
0.035225
0.023483
0.023483
0.021526
0.027397
0.011742
0.037182
0.054795
1
4,775
T
G
G
C
G
A
T
G
T
T
C
C
C
T
A
C
A
G
C
T
T
C
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C
C
T
G
G
A
C
C
T
T
T
T
G
C
A
G
T
G
A
C
T
T
T
A
C
T
G
G
C
A
T
C
T
C
C
C
T
G
G
T
0.064579
0.017613
0.050881
0.035225
0.046967
0.027397
0.005871
0.023483
0.04501
0.027397
0.054795
0.037182
0.033268
0.031311
0.043053
0.037182
0.041096
0.035225
0.023483
0.003914
0.003914
0.005871
0.021526
0.035225
0.031311
0.031311
0.023483
0.033268
0.033268
0.017613
0.029354
0.048924
1
4,776
A
T
G
A
C
A
A
T
A
A
A
G
A
T
G
G
C
A
C
G
T
A
T
G
C
T
G
T
C
A
C
C
T
A
C
A
T
C
C
C
C
G
A
C
A
A
G
A
C
T
G
G
G
C
G
C
T
A
T
A
T
G
A
T
T
G
0.052838
0.02544
0.035225
0.027397
0.052838
0.02544
0.017613
0.02544
0.043053
0.02544
0.035225
0.021526
0.037182
0.048924
0.043053
0.039139
0.035225
0.039139
0.039139
0.015656
0.007828
0.005871
0.031311
0.027397
0.027397
0.035225
0.027397
0.035225
0.029354
0.023483
0.017613
0.046967
1
4,777
A
C
C
C
C
C
G
T
A
G
G
T
G
A
C
T
C
C
A
A
T
C
A
T
A
T
A
G
C
G
C
C
C
A
G
T
C
T
T
G
T
C
G
G
G
G
A
T
G
T
A
G
G
T
G
A
C
A
G
C
A
T
A
C
G
T
0.052838
0.02544
0.037182
0.029354
0.052838
0.023483
0.017613
0.02544
0.046967
0.029354
0.033268
0.023483
0.035225
0.04501
0.046967
0.037182
0.035225
0.037182
0.037182
0.015656
0.007828
0.005871
0.033268
0.029354
0.029354
0.033268
0.027397
0.035225
0.027397
0.023483
0.013699
0.046967
1
4,778
T
C
A
C
C
T
A
C
G
G
G
G
G
T
G
A
C
G
A
C
A
T
C
C
C
A
C
T
T
T
C
T
C
C
T
T
A
T
C
G
C
A
T
C
C
G
A
G
C
C
A
C
A
C
A
G
A
C
G
G
G
T
G
A
T
T
0.046967
0.023483
0.04501
0.029354
0.048924
0.019569
0.017613
0.023483
0.052838
0.033268
0.031311
0.023483
0.037182
0.046967
0.043053
0.035225
0.035225
0.039139
0.033268
0.015656
0.007828
0.005871
0.029354
0.029354
0.037182
0.033268
0.027397
0.035225
0.031311
0.017613
0.019569
0.04501
1
4,779
A
G
A
A
G
T
A
G
G
C
T
T
T
G
T
G
G
T
T
G
A
T
G
C
C
A
A
G
A
C
T
G
C
C
G
G
G
A
A
G
G
G
T
A
A
A
G
T
G
A
C
C
T
G
C
A
C
G
G
T
T
C
T
G
A
T
0.023483
0.037182
0.039139
0.02544
0.050881
0.029354
0.007828
0.02544
0.035225
0.023483
0.046967
0.021526
0.037182
0.048924
0.033268
0.035225
0.052838
0.04501
0.035225
0.019569
0.011742
0.007828
0.013699
0.02544
0.048924
0.021526
0.029354
0.041096
0.041096
0.021526
0.019569
0.04501
1
4,780
A
G
T
G
A
A
G
G
G
G
C
T
G
T
T
A
G
G
A
A
T
A
T
C
A
A
C
A
C
C
A
C
C
G
A
A
G
C
G
C
A
C
A
T
A
G
A
T
C
A
C
A
T
A
T
G
T
G
C
C
C
G
G
C
T
T
0.050881
0.031311
0.048924
0.023483
0.043053
0.033268
0.003914
0.031311
0.04501
0.023483
0.046967
0.019569
0.027397
0.039139
0.027397
0.035225
0.046967
0.043053
0.029354
0.019569
0.011742
0.007828
0.021526
0.029354
0.054795
0.02544
0.023483
0.035225
0.041096
0.019569
0.021526
0.039139
1
4,781
G
A
T
G
G
T
G
A
A
G
G
T
G
G
C
A
G
T
T
T
T
G
T
T
G
G
C
C
A
C
T
C
C
A
T
A
C
A
C
G
A
G
G
C
C
T
G
G
A
C
C
G
T
A
T
G
C
A
G
A
A
A
C
A
C
T
0.046967
0.029354
0.041096
0.017613
0.052838
0.035225
0.029354
0.02544
0.062622
0.015656
0.043053
0.009785
0.017613
0.033268
0.027397
0.048924
0.043053
0.052838
0.027397
0.007828
0.015656
0.009785
0.019569
0.04501
0.041096
0.037182
0.02544
0.027397
0.041096
0.027397
0.021526
0.021526
1
4,782
C
T
T
A
T
G
C
A
A
A
G
A
T
T
C
T
A
G
A
G
G
A
C
A
A
C
T
C
T
A
T
A
C
C
T
C
A
G
G
T
C
A
A
A
G
A
C
A
T
C
A
T
A
T
T
T
G
C
A
A
T
A
A
A
G
T
0.078278
0.027397
0.039139
0.050881
0.035225
0.023483
0.009785
0.029354
0.043053
0.027397
0.046967
0.039139
0.019569
0.033268
0.043053
0.027397
0.048924
0.031311
0.013699
0.003914
0.005871
0.003914
0.02544
0.033268
0.04501
0.023483
0.052838
0.017613
0.041096
0.019569
0.029354
0.031311
1
4,783
G
C
T
G
G
C
C
A
C
A
G
T
T
T
G
G
A
G
T
A
G
G
A
G
C
T
G
A
A
A
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C
T
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T
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C
C
A
G
G
A
T
C
A
T
G
G
A
A
G
G
T
A
T
T
T
C
A
A
A
G
A
A
A
C
0.072407
0.029354
0.04501
0.050881
0.041096
0.02544
0.007828
0.02544
0.04501
0.031311
0.039139
0.046967
0.033268
0.041096
0.035225
0.019569
0.043053
0.04501
0.007828
0.001957
0.001957
0.003914
0.033268
0.019569
0.046967
0.013699
0.021526
0.02544
0.035225
0.037182
0.043053
0.031311
1
4,784
T
G
A
C
C
A
C
C
T
T
T
A
A
G
C
C
T
G
G
G
C
A
G
T
G
C
C
C
A
T
A
C
C
A
G
G
C
A
G
C
A
A
A
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C
A
C
T
G
T
G
A
G
T
G
C
T
G
G
G
C
A
G
C
T
G
0.082192
0.029354
0.041096
0.043053
0.033268
0.029354
0.005871
0.031311
0.029354
0.039139
0.041096
0.046967
0.023483
0.031311
0.037182
0.027397
0.054795
0.041096
0.021526
0.003914
0.003914
0.001957
0.031311
0.013699
0.029354
0.023483
0.043053
0.037182
0.021526
0.019569
0.046967
0.035225
1
4,785
C
T
A
T
A
G
G
C
A
C
A
G
G
C
T
G
A
A
G
G
C
C
A
C
C
A
G
A
C
A
T
G
T
A
G
T
A
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G
T
C
T
T
G
G
C
A
G
C
T
G
A
G
T
T
T
A
T
A
A
C
C
T
G
G
C
0.093933
0.027397
0.029354
0.046967
0.037182
0.031311
0.003914
0.031311
0.021526
0.035225
0.039139
0.033268
0.017613
0.035225
0.041096
0.039139
0.060665
0.050881
0.02544
0.003914
0.001957
0.001957
0.019569
0.017613
0.02544
0.029354
0.046967
0.037182
0.02544
0.011742
0.037182
0.041096
1
4,786
T
A
A
C
A
T
C
C
A
C
G
T
T
T
T
T
G
A
T
T
T
T
A
C
A
G
G
C
T
G
G
G
T
T
G
C
G
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C
C
C
A
T
T
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G
T
G
A
A
T
T
T
A
T
G
A
C
C
T
T
C
A
A
T
G
0.068493
0.023483
0.031311
0.039139
0.035225
0.027397
0.003914
0.039139
0.021526
0.046967
0.04501
0.02544
0.015656
0.037182
0.035225
0.039139
0.064579
0.046967
0.023483
0.003914
0.001957
0.001957
0.027397
0.029354
0.021526
0.027397
0.054795
0.041096
0.029354
0.015656
0.037182
0.039139
1
4,787
G
G
G
C
T
T
T
G
C
T
G
G
A
A
T
T
G
C
T
G
T
A
G
G
T
G
C
A
G
C
T
A
T
G
G
T
A
T
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T
A
A
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A
C
T
C
T
T
T
A
T
G
A
A
A
C
T
T
A
T
C
C
A
A
C
0.07045
0.027397
0.039139
0.037182
0.043053
0.027397
0
0.037182
0.04501
0.031311
0.039139
0.039139
0.021526
0.035225
0.033268
0.031311
0.050881
0.054795
0.027397
0
0.005871
0.005871
0.021526
0.041096
0.027397
0.02544
0.023483
0.029354
0.037182
0.023483
0.041096
0.027397
1
4,788
T
G
G
A
T
A
A
G
T
T
T
C
A
T
A
A
A
G
A
G
T
A
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A
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A
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A
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C
A
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C
T
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C
A
C
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T
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A
G
C
A
A
T
T
C
C
A
G
C
A
A
A
G
C
C
C
A
C
0.07045
0.027397
0.039139
0.037182
0.043053
0.027397
0
0.037182
0.04501
0.031311
0.039139
0.039139
0.021526
0.035225
0.035225
0.031311
0.048924
0.054795
0.027397
0
0.005871
0.005871
0.021526
0.041096
0.027397
0.02544
0.023483
0.029354
0.037182
0.023483
0.041096
0.027397
1
4,789
G
G
G
T
C
T
C
C
G
C
A
C
C
A
A
G
C
C
A
G
A
C
A
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C
G
C
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G
C
C
A
T
C
T
T
G
G
T
C
G
T
G
T
C
C
T
C
T
A
T
C
C
G
C
T
G
C
C
A
A
A
C
G
A
C
0.007828
0.007828
0.019569
0.007828
0.019569
0.043053
0.02544
0.007828
0.027397
0.029354
0.058708
0.005871
0.007828
0.005871
0.017613
0.04501
0.050881
0.037182
0.082192
0.078278
0.019569
0.088063
0.005871
0.04501
0.013699
0.037182
0.041096
0.09589
0.035225
0.007828
0.003914
0.021526
1
4,790
T
T
A
G
G
A
T
A
T
A
A
T
C
A
A
A
T
T
T
G
T
C
T
T
T
T
A
G
G
T
T
G
C
C
T
G
C
C
T
G
A
T
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G
A
G
T
T
C
C
A
T
C
T
G
A
A
G
T
G
G
T
T
A
T
0.129159
0.033268
0.060665
0.048924
0.035225
0.021526
0.001957
0.02544
0.056751
0.031311
0.037182
0.048924
0.033268
0.02544
0.033268
0.011742
0.031311
0.023483
0.009785
0.001957
0.005871
0.001957
0.037182
0.021526
0.037182
0.011742
0.02544
0.019569
0.021526
0.027397
0.07045
0.019569
1
4,791
C
C
A
A
G
G
G
T
T
G
T
A
T
C
G
A
G
G
C
T
A
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A
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A
A
G
C
A
C
A
G
T
T
T
T
A
A
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A
G
A
G
G
T
A
A
G
T
C
A
C
T
T
A
C
T
T
T
C
C
A
A
T
A
G
0.074364
0.04501
0.048924
0.058708
0.043053
0.023483
0.003914
0.043053
0.058708
0.019569
0.029354
0.062622
0.019569
0.023483
0.035225
0.017613
0.035225
0.017613
0.011742
0.005871
0.009785
0
0.029354
0.037182
0.054795
0.015656
0.013699
0.009785
0.019569
0.035225
0.060665
0.037182
1
4,792
T
A
C
A
G
G
T
G
G
A
T
T
T
G
C
C
G
C
T
G
C
A
G
T
C
A
C
C
A
C
C
C
C
T
C
T
A
G
A
C
G
T
G
G
C
A
A
A
G
A
C
A
A
G
A
A
T
T
A
C
G
C
T
G
G
T
0.056751
0.019569
0.027397
0.058708
0.062622
0.031311
0.009785
0.029354
0.041096
0.023483
0.027397
0.039139
0.027397
0.046967
0.037182
0.048924
0.048924
0.037182
0.017613
0.001957
0.003914
0.007828
0.02544
0.019569
0.035225
0.017613
0.04501
0.017613
0.017613
0.04501
0.035225
0.037182
1
4,793
A
A
A
A
A
C
T
A
A
C
C
T
C
A
T
T
T
T
G
G
T
T
A
A
G
G
A
T
T
T
T
C
C
G
G
T
A
T
T
C
T
G
T
G
C
T
C
C
G
T
G
C
A
A
G
A
A
T
G
G
T
G
A
C
T
T
0.129159
0.043053
0.031311
0.066536
0.02544
0.035225
0.007828
0.027397
0.033268
0.021526
0.021526
0.035225
0.029354
0.048924
0.041096
0.029354
0.019569
0.031311
0.009785
0.013699
0.005871
0
0.027397
0.02544
0.052838
0.003914
0.031311
0.013699
0.017613
0.019569
0.046967
0.054795
1
4,794
T
T
T
C
C
G
A
A
A
C
A
G
A
T
A
C
G
T
T
A
A
A
A
A
T
A
T
C
T
T
A
C
C
A
T
G
A
C
T
G
C
A
G
A
G
G
G
C
T
T
T
T
G
C
G
C
T
G
A
C
C
T
T
C
A
G
0.107632
0.035225
0.04501
0.07045
0.031311
0.015656
0.021526
0.046967
0.033268
0.015656
0.013699
0.046967
0.021526
0.037182
0.035225
0.021526
0.033268
0.029354
0.011742
0.009785
0.003914
0.003914
0.011742
0.019569
0.04501
0.019569
0.02544
0.009785
0.027397
0.039139
0.07045
0.041096
1
4,795
G
G
A
G
C
A
A
A
A
T
A
C
C
C
A
C
C
G
T
T
T
C
C
T
T
A
G
G
C
T
G
A
C
A
G
A
G
C
A
C
A
T
G
C
A
T
C
T
C
C
T
C
C
A
G
C
C
T
C
T
C
T
C
T
G
T
0.113503
0.029354
0.033268
0.056751
0.02544
0.019569
0.011742
0.035225
0.029354
0.033268
0.043053
0.04501
0.011742
0.019569
0.033268
0.021526
0.041096
0.029354
0.02544
0.007828
0.003914
0.015656
0.02544
0.041096
0.031311
0.017613
0.031311
0.021526
0.039139
0.023483
0.054795
0.029354
1
4,796
T
A
A
A
C
G
A
C
A
T
T
C
G
T
C
A
C
A
G
C
A
G
T
G
T
C
G
C
C
T
A
T
C
T
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A
A
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C
C
T
G
T
A
A
G
T
A
G
A
A
G
G
A
G
G
G
A
G
A
A
A
T
G
G
T
0.041096
0.029354
0.031311
0.035225
0.031311
0.033268
0.011742
0.031311
0.041096
0.039139
0.037182
0.023483
0.033268
0.037182
0.023483
0.029354
0.04501
0.039139
0.043053
0.015656
0.017613
0.013699
0.031311
0.041096
0.037182
0.019569
0.029354
0.023483
0.035225
0.027397
0.035225
0.037182
1
4,797
T
T
A
C
A
G
G
T
T
T
A
A
G
A
T
A
G
G
C
G
A
C
A
C
T
G
C
T
G
T
G
A
C
G
A
A
T
G
T
C
G
T
T
T
A
G
C
A
G
C
T
G
A
T
C
T
C
T
G
G
G
A
G
T
G
A
0.04501
0.029354
0.033268
0.035225
0.031311
0.033268
0.011742
0.033268
0.041096
0.031311
0.037182
0.023483
0.033268
0.037182
0.027397
0.029354
0.043053
0.039139
0.04501
0.015656
0.017613
0.013699
0.029354
0.039139
0.037182
0.023483
0.02544
0.023483
0.035225
0.027397
0.033268
0.039139
1
4,798
G
A
A
A
C
C
G
A
A
G
C
T
C
A
G
T
T
A
G
C
G
T
C
T
C
A
T
T
A
A
A
C
T
G
G
A
G
A
C
A
C
C
T
C
A
T
G
A
T
G
G
C
C
A
C
A
A
T
C
C
C
T
T
T
A
C
0.066536
0.046967
0.035225
0.041096
0.052838
0.02544
0.005871
0.021526
0.033268
0.041096
0.031311
0.007828
0.031311
0.064579
0.050881
0.031311
0.043053
0.041096
0.015656
0.005871
0.007828
0.003914
0.017613
0.031311
0.050881
0.019569
0.033268
0.023483
0.029354
0.007828
0.019569
0.062622
1
4,799
A
A
T
A
A
A
A
C
C
A
A
C
T
T
A
C
T
C
A
G
G
T
T
G
T
G
A
T
T
G
T
C
C
T
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T
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C
T
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C
C
T
C
T
C
T
T
T
G
G
C
C
A
G
T
G
C
T
C
T
T
G
C
G
0.133072
0.037182
0.043053
0.064579
0.04501
0.007828
0.009785
0.031311
0.048924
0.019569
0.011742
0.093933
0.021526
0.035225
0.052838
0.015656
0.031311
0.021526
0.011742
0
0
0.001957
0.009785
0.027397
0.052838
0.013699
0.019569
0.005871
0.019569
0.027397
0.039139
0.046967
1
4,800
T
G
A
A
C
A
T
A
A
A
T
A
A
A
A
C
C
A
A
C
T
T
A
C
T
C
A
G
G
T
T
G
T
G
A
T
T
G
T
C
C
T
T
T
T
T
C
T
G
C
C
T
C
T
C
T
T
T
G
G
C
C
A
G
T
C
0.135029
0.039139
0.043053
0.062622
0.04501
0.007828
0.009785
0.033268
0.050881
0.019569
0.011742
0.086106
0.021526
0.035225
0.050881
0.015656
0.031311
0.021526
0.011742
0
0
0.001957
0.013699
0.027397
0.054795
0.013699
0.019569
0.005871
0.019569
0.02544
0.039139
0.046967
1
4,801
G
C
C
A
A
A
G
A
G
A
G
G
C
A
G
A
A
A
A
A
G
G
A
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A
A
T
C
A
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C
T
G
A
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A
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G
T
T
T
T
A
T
T
T
A
T
G
T
T
C
A
T
G
A
C
G
0.135029
0.039139
0.043053
0.062622
0.04501
0.007828
0.009785
0.035225
0.050881
0.019569
0.011742
0.082192
0.021526
0.033268
0.050881
0.017613
0.031311
0.021526
0.011742
0
0
0.001957
0.015656
0.027397
0.054795
0.013699
0.019569
0.005871
0.019569
0.027397
0.039139
0.04501
1
4,802
T
A
G
T
T
C
T
T
T
A
A
T
G
C
G
G
T
C
A
T
T
T
A
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G
T
T
A
A
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T
C
T
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C
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T
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A
A
C
T
T
C
A
A
G
A
A
A
A
G
A
G
C
A
C
A
C
0.103718
0.041096
0.056751
0.052838
0.037182
0.023483
0.015656
0.031311
0.046967
0.017613
0.029354
0.033268
0.021526
0.052838
0.039139
0.013699
0.019569
0.015656
0.013699
0.005871
0.007828
0.005871
0.029354
0.019569
0.056751
0.015656
0.031311
0.007828
0.019569
0.037182
0.056751
0.041096
1
4,803
T
G
C
G
C
T
G
G
A
A
C
A
A
G
G
G
A
A
C
C
A
T
C
T
T
A
A
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C
A
T
C
C
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T
G
G
A
C
T
A
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A
T
C
C
G
A
A
A
G
T
T
G
C
A
A
C
G
A
G
A
A
C
0.101761
0.043053
0.039139
0.04501
0.046967
0.027397
0.015656
0.035225
0.027397
0.023483
0.021526
0.033268
0.027397
0.02544
0.048924
0.039139
0.033268
0.037182
0.019569
0.013699
0.011742
0.017613
0.013699
0.021526
0.04501
0.013699
0.029354
0.011742
0.033268
0.029354
0.033268
0.035225
1
4,804
T
T
G
T
G
C
G
A
G
T
A
G
A
A
A
A
C
G
T
T
A
A
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A
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A
A
G
T
A
G
A
A
T
T
C
C
A
A
A
A
A
C
G
A
C
0.09002
0.041096
0.052838
0.027397
0.041096
0.027397
0.021526
0.033268
0.043053
0.037182
0.02544
0.023483
0.019569
0.033268
0.04501
0.031311
0.037182
0.046967
0.029354
0.001957
0.003914
0.003914
0.029354
0.019569
0.037182
0.023483
0.037182
0.015656
0.031311
0.029354
0.039139
0.021526
1
4,805
C
G
T
T
T
T
C
T
A
C
T
C
G
C
A
C
A
A
A
A
C
A
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T
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T
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A
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A
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G
C
A
C
T
G
C
A
T
T
C
T
G
C
A
G
C
A
A
G
T
0.09589
0.041096
0.050881
0.037182
0.039139
0.023483
0.02544
0.037182
0.046967
0.033268
0.021526
0.023483
0.019569
0.033268
0.041096
0.027397
0.033268
0.04501
0.019569
0.001957
0.007828
0.003914
0.033268
0.021526
0.039139
0.023483
0.029354
0.015656
0.029354
0.031311
0.048924
0.019569
1
4,806
T
C
T
C
T
C
T
T
T
T
A
T
A
C
T
T
G
C
T
G
C
A
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A
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G
C
A
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A
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A
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G
T
C
T
T
C
A
C
A
A
G
T
G
T
T
T
T
G
T
G
T
0.093933
0.039139
0.050881
0.039139
0.035225
0.02544
0.02544
0.037182
0.048924
0.035225
0.017613
0.02544
0.019569
0.033268
0.039139
0.027397
0.035225
0.046967
0.017613
0.001957
0.007828
0.003914
0.033268
0.019569
0.041096
0.02544
0.031311
0.015656
0.02544
0.031311
0.048924
0.021526
1
4,807
G
T
T
A
T
T
T
A
C
T
T
A
C
C
T
G
C
C
T
A
A
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T
A
A
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A
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C
A
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T
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G
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G
G
T
C
T
A
A
C
T
T
C
T
G
C
G
T
T
C
T
T
A
A
0.072407
0.029354
0.035225
0.066536
0.043053
0.031311
0.017613
0.023483
0.039139
0.013699
0.027397
0.07045
0.029354
0.04501
0.035225
0.031311
0.037182
0.023483
0.013699
0.007828
0.003914
0.009785
0.019569
0.011742
0.037182
0.015656
0.043053
0.017613
0.011742
0.039139
0.058708
0.039139
1
4,808
G
T
T
A
T
T
T
A
C
T
T
A
C
C
T
G
C
C
T
A
A
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A
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A
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C
A
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T
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G
T
C
T
A
A
C
T
T
C
T
G
C
G
T
T
C
T
T
A
C
0.072407
0.029354
0.035225
0.066536
0.043053
0.031311
0.017613
0.023483
0.039139
0.013699
0.027397
0.07045
0.029354
0.04501
0.035225
0.031311
0.037182
0.023483
0.013699
0.007828
0.003914
0.009785
0.019569
0.011742
0.037182
0.015656
0.043053
0.017613
0.011742
0.039139
0.058708
0.039139
1
4,809
A
C
C
A
A
G
A
A
T
T
T
T
A
T
A
A
G
A
A
C
G
C
A
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A
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T
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A
T
G
C
A
T
C
T
T
T
A
A
T
T
A
G
G
C
A
G
A
0.068493
0.027397
0.035225
0.066536
0.041096
0.033268
0.019569
0.023483
0.037182
0.013699
0.029354
0.07045
0.027397
0.043053
0.037182
0.033268
0.035225
0.023483
0.017613
0.009785
0.003914
0.009785
0.019569
0.011742
0.037182
0.017613
0.043053
0.015656
0.013699
0.039139
0.054795
0.041096
1
4,810
G
C
C
T
A
A
T
T
A
A
A
G
A
T
G
C
A
T
A
T
G
T
A
A
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G
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G
G
T
C
T
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A
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T
G
C
G
T
T
C
T
T
A
T
A
A
A
A
T
T
C
T
T
G
G
T
T
C
G
0.068493
0.027397
0.035225
0.066536
0.041096
0.033268
0.019569
0.02544
0.037182
0.013699
0.027397
0.07045
0.027397
0.043053
0.037182
0.033268
0.035225
0.023483
0.017613
0.009785
0.003914
0.009785
0.019569
0.013699
0.037182
0.017613
0.043053
0.013699
0.013699
0.039139
0.054795
0.041096
1
4,811
A
C
T
C
T
A
C
G
T
G
A
G
G
C
A
A
A
A
G
G
T
G
G
A
G
T
A
T
C
T
A
C
C
T
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A
C
G
A
A
A
T
G
G
G
C
A
C
G
T
T
G
T
A
T
T
T
G
T
C
T
G
A
G
T
T
0.043053
0.027397
0.041096
0.043053
0.035225
0.041096
0.021526
0.027397
0.052838
0.013699
0.031311
0.050881
0.02544
0.033268
0.041096
0.031311
0.043053
0.037182
0.031311
0.013699
0.005871
0.013699
0.013699
0.029354
0.037182
0.029354
0.037182
0.017613
0.023483
0.035225
0.033268
0.039139
1
4,812
A
C
A
T
G
C
C
T
C
C
A
C
C
A
C
A
T
T
G
G
G
A
G
T
C
C
T
T
G
T
C
A
C
A
A
G
C
C
T
G
A
A
A
T
G
T
A
A
T
A
A
A
C
A
A
A
C
A
G
A
T
A
A
A
T
T
0.074364
0.027397
0.031311
0.058708
0.046967
0.021526
0.005871
0.033268
0.029354
0.033268
0.031311
0.080235
0.027397
0.039139
0.027397
0.029354
0.04501
0.031311
0.019569
0
0.009785
0
0.031311
0.019569
0.029354
0.02544
0.02544
0.015656
0.02544
0.02544
0.062622
0.037182
1
4,813
G
G
G
G
C
A
G
A
C
A
G
G
T
G
C
G
C
C
C
G
G
G
C
C
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C
T
T
A
C
C
C
C
G
G
T
G
A
T
C
A
C
G
G
C
G
G
C
G
T
C
C
C
C
A
G
C
G
C
G
G
G
G
C
G
G
0.015656
0.005871
0.02544
0.003914
0.017613
0.027397
0.019569
0.013699
0.011742
0.043053
0.050881
0.007828
0.013699
0.009785
0.015656
0.037182
0.054795
0.041096
0.111546
0.074364
0.009785
0.097847
0.007828
0.031311
0.009785
0.029354
0.041096
0.09589
0.043053
0.005871
0.009785
0.017613
1
4,814
G
C
T
T
A
C
C
C
C
G
G
T
G
A
T
C
A
C
G
G
C
G
G
C
G
T
C
C
C
C
A
G
C
G
C
G
G
G
G
C
G
T
G
A
G
C
A
G
C
A
G
C
G
G
C
G
G
C
A
G
C
A
G
C
A
G
0.013699
0.005871
0.021526
0.001957
0.019569
0.019569
0.023483
0.013699
0.011742
0.04501
0.046967
0.005871
0.013699
0.009785
0.015656
0.037182
0.056751
0.035225
0.117417
0.080235
0.009785
0.101761
0.007828
0.031311
0.007828
0.029354
0.046967
0.099804
0.043053
0.003914
0.005871
0.017613
1
4,815
A
C
A
T
G
C
A
C
A
C
A
T
A
C
A
T
G
C
A
C
T
T
A
C
A
T
T
C
T
T
C
T
C
T
C
C
T
T
C
A
G
T
G
A
C
A
C
G
G
G
T
T
T
C
A
T
A
G
C
A
A
T
A
T
G
T
0.078278
0.033268
0.046967
0.041096
0.043053
0.019569
0.007828
0.050881
0.062622
0.019569
0.009785
0.031311
0.029354
0.046967
0.037182
0.039139
0.041096
0.031311
0.019569
0.001957
0.003914
0.001957
0.033268
0.023483
0.048924
0.023483
0.046967
0.009785
0.013699
0.02544
0.035225
0.043053
1
4,816
C
T
T
C
T
G
T
C
T
T
C
G
T
T
C
A
G
C
T
G
C
A
G
G
G
G
T
G
A
A
A
T
C
T
G
G
A
T
C
C
T
T
A
A
T
A
T
C
A
A
T
A
A
C
A
T
C
A
C
T
C
A
G
T
T
A
0.088063
0.02544
0.035225
0.080235
0.037182
0.021526
0.001957
0.02544
0.041096
0.021526
0.037182
0.027397
0.052838
0.039139
0.037182
0.021526
0.043053
0.02544
0.009785
0.003914
0.003914
0.005871
0.021526
0.027397
0.033268
0.015656
0.021526
0.017613
0.027397
0.023483
0.07045
0.056751
1
4,817
C
A
T
T
T
A
A
A
G
T
C
T
G
G
C
A
G
A
T
G
T
A
A
T
A
A
C
C
A
A
C
A
T
C
A
G
A
T
C
G
C
T
G
G
A
C
A
T
T
A
G
T
A
A
T
T
G
T
G
A
G
G
T
C
G
C
0.099804
0.033268
0.031311
0.062622
0.050881
0.02544
0.001957
0.033268
0.033268
0.013699
0.021526
0.080235
0.033268
0.052838
0.033268
0.02544
0.027397
0.041096
0.009785
0.003914
0.005871
0.003914
0.029354
0.013699
0.029354
0.017613
0.019569
0.013699
0.027397
0.033268
0.064579
0.027397
1
4,818
T
T
C
C
T
T
T
T
C
T
T
G
G
G
A
A
G
T
C
T
A
A
C
C
A
T
T
C
A
G
G
A
T
G
C
C
C
A
A
A
T
T
C
A
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T
A
C
C
T
G
C
A
T
T
A
C
A
A
A
A
C
A
C
A
C
0.068493
0.02544
0.033268
0.074364
0.037182
0.029354
0.005871
0.027397
0.035225
0.035225
0.035225
0.043053
0.023483
0.046967
0.033268
0.021526
0.041096
0.035225
0.009785
0.003914
0.005871
0.003914
0.039139
0.019569
0.039139
0.021526
0.033268
0.021526
0.023483
0.029354
0.060665
0.037182
1
4,819
A
A
C
A
T
T
T
C
T
A
T
A
T
T
G
T
A
T
G
T
A
C
C
T
A
C
C
T
G
G
A
G
T
A
G
G
C
A
A
A
C
A
A
T
C
T
G
C
T
A
T
C
C
C
A
A
A
G
A
T
C
A
T
G
A
G
0.084149
0.033268
0.02544
0.080235
0.074364
0.021526
0.003914
0.015656
0.043053
0.023483
0.021526
0.056751
0.031311
0.056751
0.041096
0.02544
0.029354
0.031311
0.011742
0.001957
0
0.001957
0.029354
0.019569
0.043053
0.009785
0.013699
0.007828
0.02544
0.046967
0.054795
0.035225
1
4,820
T
A
A
A
A
G
C
G
G
A
G
A
G
A
T
C
T
T
G
T
A
T
C
G
T
A
T
T
T
C
A
C
C
G
T
G
G
G
C
A
A
A
G
T
A
T
G
T
G
G
T
T
C
G
T
G
A
A
G
G
T
G
A
T
A
T
0.062622
0.035225
0.043053
0.054795
0.048924
0.019569
0.007828
0.04501
0.04501
0.015656
0.023483
0.072407
0.043053
0.04501
0.02544
0.027397
0.033268
0.02544
0.003914
0.003914
0.003914
0.003914
0.033268
0.021526
0.043053
0.013699
0.013699
0.003914
0.029354
0.04501
0.064579
0.043053
1
4,821
T
T
C
C
C
A
A
A
T
G
A
A
G
A
T
G
G
C
T
G
G
A
G
C
A
A
T
G
T
C
T
A
C
T
A
C
A
G
C
A
A
A
A
G
T
A
A
G
T
G
A
G
A
G
C
T
T
T
T
A
T
A
T
T
C
A
0.133072
0.031311
0.060665
0.082192
0.043053
0.009785
0.009785
0.029354
0.056751
0.021526
0.013699
0.056751
0.029354
0.023483
0.050881
0.017613
0.015656
0.017613
0.003914
0.003914
0.005871
0
0.029354
0.015656
0.052838
0.011742
0.017613
0.007828
0.017613
0.033268
0.068493
0.029354
1
4,822
T
T
C
T
T
C
T
T
C
G
T
C
A
T
C
A
G
A
A
C
C
G
T
C
A
A
A
G
A
T
G
T
C
A
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C
A
A
G
T
G
T
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T
C
A
T
T
G
A
C
T
A
G
G
G
G
A
T
A
T
G
G
G
A
A
0.099804
0.04501
0.046967
0.062622
0.050881
0.013699
0.007828
0.043053
0.039139
0.013699
0.027397
0.04501
0.029354
0.039139
0.054795
0.017613
0.029354
0.021526
0.007828
0.001957
0.001957
0
0.031311
0.013699
0.054795
0.023483
0.015656
0.009785
0.027397
0.029354
0.043053
0.052838
1
4,823
T
C
T
T
T
T
G
A
C
T
A
A
T
C
T
A
C
T
C
C
T
A
A
A
G
C
C
T
T
G
A
G
T
T
G
C
C
G
T
T
C
A
A
T
C
T
C
T
T
C
A
T
C
T
G
A
G
A
T
T
G
T
A
G
C
G
0.123288
0.043053
0.041096
0.050881
0.046967
0.015656
0.009785
0.037182
0.041096
0.02544
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0.027397
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0.027397
0.003914
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0
0.037182
0.021526
0.035225
0.017613
0.035225
0.017613
0.021526
0.029354
0.050881
0.035225
1
4,824
C
T
C
T
G
G
A
G
A
G
A
C
A
C
T
T
T
G
G
A
G
A
A
C
A
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A
A
T
A
A
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C
C
T
T
C
T
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C
T
C
A
A
G
A
G
A
T
C
A
T
G
A
G
G
A
T
G
G
C
T
G
A
A
T
0.107632
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0.066536
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0.017613
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0.009785
0
0.001957
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0.056751
0.013699
0.023483
0.009785
0.027397
0.019569
0.048924
0.039139
1
4,825
A
G
A
A
G
G
T
T
T
A
T
T
C
T
G
T
T
C
T
C
C
A
A
A
G
T
G
T
C
T
C
T
C
C
A
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A
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C
A
T
C
T
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T
A
G
C
A
G
C
A
A
T
G
C
T
G
G
C
G
G
G
G
G
T
0.099804
0.046967
0.052838
0.04501
0.04501
0.017613
0.007828
0.033268
0.068493
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0.04501
0.058708
0.013699
0.02544
0.009785
0.029354
0.019569
0.046967
0.037182
1
4,826
A
T
G
C
A
T
G
C
A
A
A
C
T
G
A
A
A
G
C
A
A
T
A
T
T
A
T
C
C
A
A
A
T
G
G
C
T
G
G
A
G
G
A
A
G
C
T
G
A
G
C
A
A
G
T
A
G
G
A
G
G
T
A
C
T
C
0.107632
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0.035225
0.064579
0.058708
0.015656
0
0.021526
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0.029354
0.052838
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0.041096
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0.019569
0.033268
0.015656
0.050881
0.037182
1
4,827
A
C
A
A
T
C
T
G
C
C
G
A
T
T
T
G
A
A
A
A
T
C
T
G
C
A
G
C
T
C
A
G
C
T
T
T
A
A
A
A
A
T
G
C
A
T
G
C
A
A
A
C
T
G
A
A
A
G
C
A
A
T
A
T
T
G
0.105675
0.035225
0.037182
0.068493
0.058708
0.013699
0
0.023483
0.029354
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0.033268
0.043053
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0.031311
0.054795
0.027397
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0.035225
0.013699
0.033268
0.021526
0.027397
0.019569
0.050881
0.039139
1
4,828
T
G
T
T
T
G
A
C
T
G
A
A
T
T
C
A
G
A
G
C
C
A
T
G
C
A
C
A
G
C
T
G
C
C
A
G
G
G
C
C
T
C
C
C
C
A
A
C
A
T
T
T
G
T
C
T
G
G
G
T
G
T
A
T
C
G
0.093933
0.029354
0.043053
0.072407
0.046967
0.013699
0
0.033268
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0.037182
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0.04501
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0.029354
0.052838
0.023483
0.043053
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0.013699
0.003914
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0.02544
0.023483
0.039139
0.013699
0.035225
0.019569
0.02544
0.02544
0.052838
0.039139
1
4,829
T
T
G
C
C
T
T
T
A
A
C
A
A
G
C
A
C
A
T
A
C
C
T
A
A
T
T
T
A
A
T
T
C
G
T
C
T
C
A
C
T
T
T
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A
A
T
T
C
A
T
T
G
G
C
A
A
A
C
T
T
T
T
C
A
T
0.103718
0.035225
0.050881
0.072407
0.035225
0.021526
0.007828
0.031311
0.048924
0.019569
0.033268
0.039139
0.019569
0.029354
0.04501
0.017613
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0.031311
0.007828
0.001957
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0.001957
0.019569
0.033268
0.048924
0.019569
0.019569
0.013699
0.031311
0.023483
0.066536
0.037182
1
4,830
G
G
A
T
T
C
T
C
C
A
G
A
A
A
T
C
A
G
A
G
A
A
C
T
T
G
A
A
A
A
G
T
T
T
G
C
C
A
A
T
G
A
A
T
T
T
A
A
A
G
T
G
A
G
A
C
G
A
A
T
T
A
A
A
T
G
0.101761
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0.052838
0.074364
0.033268
0.019569
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0.027397
0.054795
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0.033268
0.052838
0.019569
0.019569
0.013699
0.033268
0.021526
0.066536
0.033268
1
4,831
C
T
T
A
T
A
C
A
T
T
T
T
C
T
T
A
C
C
A
G
T
C
C
C
A
T
C
T
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G
T
C
T
T
T
G
A
T
C
C
A
A
A
C
T
C
C
T
A
A
A
T
G
T
T
T
G
T
G
C
A
G
0.088063
0.043053
0.037182
0.058708
0.058708
0.017613
0.015656
0.029354
0.039139
0.009785
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0.031311
0.033268
0.052838
0.041096
0.035225
0.02544
0.031311
0.027397
0.005871
0.009785
0
0.017613
0.021526
0.046967
0.023483
0.015656
0.013699
0.029354
0.019569
0.048924
0.048924
1
4,832
A
T
C
C
T
T
A
T
A
C
A
T
T
T
T
C
T
T
A
C
C
A
G
T
C
C
C
A
T
C
T
A
T
T
T
T
G
T
C
T
T
T
G
A
T
C
C
A
A
A
C
T
C
C
T
A
A
A
T
G
T
T
T
G
T
G
0.086106
0.043053
0.037182
0.054795
0.058708
0.017613
0.015656
0.031311
0.039139
0.009785
0.023483
0.031311
0.033268
0.052838
0.041096
0.035225
0.027397
0.031311
0.027397
0.005871
0.009785
0
0.017613
0.021526
0.046967
0.02544
0.015656
0.013699
0.029354
0.019569
0.048924
0.048924
1
4,833
T
T
G
A
A
T
C
C
T
T
A
T
A
C
A
T
T
T
T
C
T
T
A
C
C
A
G
T
C
C
C
A
T
C
T
A
T
T
T
T
G
T
C
T
T
T
G
A
T
C
C
A
A
A
C
T
C
C
T
A
A
A
T
G
T
G
0.084149
0.043053
0.037182
0.054795
0.058708
0.019569
0.015656
0.031311
0.039139
0.009785
0.023483
0.031311
0.033268
0.052838
0.039139
0.035225
0.027397
0.033268
0.027397
0.005871
0.009785
0
0.017613
0.021526
0.04501
0.027397
0.015656
0.013699
0.029354
0.019569
0.048924
0.048924
1
4,834
A
C
C
T
C
T
G
A
A
T
T
C
T
G
A
C
G
C
C
T
C
T
G
C
A
A
C
T
C
T
G
C
C
T
C
T
G
A
T
A
A
T
G
C
A
T
C
A
C
A
G
T
G
C
T
G
C
C
G
A
G
T
G
T
C
T
0.062622
0.017613
0.041096
0.062622
0.027397
0.023483
0.001957
0.035225
0.046967
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0.035225
0.058708
0.02544
0.043053
0.033268
0.019569
0.041096
0.023483
0.017613
0.011742
0.005871
0.011742
0.019569
0.039139
0.033268
0.017613
0.043053
0.027397
0.019569
0.033268
0.054795
0.043053
1
4,835
T
T
T
C
T
A
A
A
C
A
T
A
A
T
G
A
T
A
T
T
A
G
A
G
C
T
C
A
C
T
C
A
T
G
T
C
C
A
T
C
A
G
T
T
T
G
G
A
A
A
A
A
G
A
C
A
A
A
G
A
A
T
T
C
T
C
0.101761
0.02544
0.060665
0.072407
0.046967
0.013699
0
0.035225
0.048924
0.017613
0.027397
0.050881
0.027397
0.037182
0.033268
0.031311
0.033268
0.031311
0.003914
0
0
0
0.021526
0.013699
0.060665
0.019569
0.019569
0.009785
0.035225
0.019569
0.064579
0.037182
1
4,836
C
A
C
A
C
C
A
G
T
G
A
A
T
G
C
C
T
T
T
T
A
T
A
A
T
G
G
C
T
G
C
A
T
G
G
A
A
G
T
G
A
A
T
A
T
T
A
A
T
G
G
T
G
T
A
C
A
G
T
T
G
G
A
T
C
C
0.082192
0.029354
0.052838
0.07045
0.052838
0.013699
0.001957
0.037182
0.037182
0.017613
0.02544
0.052838
0.023483
0.056751
0.029354
0.027397
0.033268
0.033268
0.003914
0.001957
0.001957
0.001957
0.017613
0.013699
0.058708
0.023483
0.019569
0.011742
0.035225
0.02544
0.064579
0.043053
1
4,837
C
C
A
A
C
T
G
T
A
C
A
C
C
A
T
T
A
A
T
A
T
T
C
A
C
T
T
C
C
A
T
G
C
A
G
C
C
A
T
T
A
T
A
A
A
A
G
G
C
A
T
T
C
A
C
T
G
G
T
G
T
G
G
C
A
T
0.082192
0.029354
0.052838
0.07045
0.050881
0.013699
0.001957
0.037182
0.037182
0.017613
0.027397
0.052838
0.023483
0.056751
0.029354
0.027397
0.033268
0.033268
0.003914
0.001957
0.001957
0.001957
0.017613
0.015656
0.058708
0.021526
0.019569
0.011742
0.037182
0.02544
0.064579
0.041096
1
4,838
T
T
C
T
G
T
T
A
T
C
T
G
T
T
G
A
A
A
A
T
A
C
T
G
T
A
A
T
A
T
A
T
C
G
G
A
T
A
C
A
G
G
C
C
C
T
A
A
G
T
C
T
A
T
G
T
T
C
C
G
A
T
C
A
A
T
0.109589
0.029354
0.054795
0.07045
0.033268
0.013699
0.001957
0.043053
0.046967
0.017613
0.021526
0.068493
0.031311
0.023483
0.04501
0.015656
0.027397
0.021526
0.007828
0.007828
0.009785
0
0.021526
0.02544
0.037182
0.023483
0.017613
0.015656
0.021526
0.023483
0.074364
0.039139
1
4,839
C
A
T
C
A
C
A
A
T
A
G
C
A
A
G
T
G
T
A
A
C
C
T
C
C
A
G
G
G
T
A
A
T
T
G
A
C
A
C
A
A
A
G
C
T
G
A
G
C
A
C
A
C
A
T
G
T
T
C
T
C
A
G
A
G
C
0.076321
0.039139
0.037182
0.066536
0.054795
0.015656
0.007828
0.033268
0.035225
0.023483
0.027397
0.066536
0.035225
0.054795
0.037182
0.023483
0.02544
0.011742
0.013699
0
0.005871
0.001957
0.031311
0.02544
0.035225
0.013699
0.021526
0.003914
0.017613
0.035225
0.07045
0.052838
1
4,840
T
G
A
C
A
C
A
A
A
G
C
T
G
A
G
C
A
C
A
C
A
T
G
T
T
C
T
C
A
G
A
G
C
A
T
T
C
A
T
C
T
A
T
A
T
C
T
G
A
G
G
T
A
A
A
A
A
A
A
A
C
A
C
A
C
G
0.086106
0.041096
0.037182
0.07045
0.052838
0.013699
0.007828
0.033268
0.035225
0.023483
0.027397
0.066536
0.037182
0.04501
0.037182
0.02544
0.027397
0.007828
0.011742
0
0.005871
0.001957
0.029354
0.02544
0.039139
0.009785
0.021526
0.003914
0.017613
0.031311
0.074364
0.052838
1
4,841
T
C
C
T
A
C
C
T
T
C
A
C
A
A
G
A
C
T
T
T
G
A
T
T
T
G
A
G
A
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A
T
A
T
C
T
G
T
A
G
C
C
T
T
C
G
G
G
G
C
A
T
T
C
A
C
A
T
T
C
A
A
A
A
C
0.07045
0.029354
0.046967
0.050881
0.048924
0.029354
0.001957
0.017613
0.035225
0.029354
0.031311
0.058708
0.046967
0.050881
0.052838
0.033268
0.027397
0.046967
0.021526
0.001957
0.001957
0.001957
0.019569
0.017613
0.033268
0.011742
0.021526
0.02544
0.02544
0.021526
0.041096
0.046967
1
4,842
T
A
C
C
A
T
C
C
T
G
C
T
C
T
T
A
C
C
T
T
T
A
C
A
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C
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T
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A
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C
A
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A
A
C
A
A
A
A
C
C
A
T
T
T
T
T
A
C
A
G
G
C
0.113503
0.033268
0.033268
0.060665
0.043053
0.02544
0.003914
0.035225
0.039139
0.023483
0.027397
0.048924
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0.033268
0.037182
0.027397
0.037182
0.035225
0.021526
0.001957
0.003914
0.001957
0.019569
0.035225
0.031311
0.013699
0.023483
0.009785
0.029354
0.033268
0.058708
0.033268
1
4,843
T
C
T
T
A
T
T
T
G
A
A
A
G
C
A
T
A
A
C
A
A
A
A
C
C
A
T
T
T
T
T
A
C
A
G
G
A
A
C
A
G
T
G
G
T
A
A
C
T
T
C
C
A
G
G
T
G
T
A
T
T
A
T
C
A
T
0.121331
0.033268
0.043053
0.060665
0.043053
0.02544
0.003914
0.033268
0.039139
0.023483
0.027397
0.048924
0.02544
0.029354
0.041096
0.02544
0.035225
0.031311
0.021526
0.001957
0.003914
0.001957
0.017613
0.027397
0.035225
0.013699
0.027397
0.005871
0.029354
0.033268
0.060665
0.029354
1
4,844
A
G
C
A
G
C
G
C
C
C
C
G
C
A
G
C
G
C
C
C
A
C
C
C
A
G
G
A
C
C
C
T
C
A
T
T
T
C
G
A
A
G
C
G
C
G
C
G
G
A
G
G
C
G
C
C
G
G
C
A
G
G
G
A
C
G
0.019569
0.013699
0.021526
0.013699
0.019569
0.023483
0.015656
0.021526
0.033268
0.062622
0.043053
0.005871
0.011742
0.011742
0.011742
0.02544
0.060665
0.039139
0.058708
0.054795
0.02544
0.088063
0.02544
0.052838
0.031311
0.029354
0.037182
0.058708
0.054795
0.009785
0.005871
0.013699
1
4,845
C
A
G
C
G
C
C
C
C
G
C
A
G
C
G
C
C
C
A
C
C
C
A
G
G
A
C
C
C
T
C
A
T
T
T
C
G
A
A
G
C
G
C
G
C
G
G
A
G
G
C
G
C
C
G
G
C
A
G
G
G
A
C
G
G
G
0.019569
0.013699
0.021526
0.013699
0.021526
0.023483
0.015656
0.021526
0.033268
0.062622
0.041096
0.005871
0.011742
0.011742
0.011742
0.027397
0.060665
0.039139
0.058708
0.054795
0.02544
0.088063
0.02544
0.052838
0.031311
0.029354
0.037182
0.058708
0.052838
0.009785
0.005871
0.013699
1
4,846
T
G
A
T
T
T
T
T
A
A
A
T
T
T
C
T
A
T
T
A
T
T
T
T
A
A
G
A
A
A
G
G
T
G
A
C
T
C
T
T
T
T
G
A
T
G
G
T
G
G
G
A
C
T
T
G
A
T
A
A
T
G
C
T
G
G
0.107632
0.023483
0.052838
0.097847
0.033268
0.017613
0
0.029354
0.039139
0.023483
0.02544
0.060665
0.029354
0.031311
0.04501
0.019569
0.021526
0.019569
0.007828
0.001957
0.001957
0.003914
0.02544
0.019569
0.041096
0.011742
0.031311
0.003914
0.02544
0.02544
0.088063
0.035225
1