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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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A
A
A
A
C
A
A
A
A
T
T
G
A
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C
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C
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1
4,948
A
A
C
A
A
A
A
T
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A
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C
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1
4,949
A
A
C
A
A
A
A
T
T
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A
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1
4,950
G
A
T
T
C
T
T
T
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A
A
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C
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T
G
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A
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T
C
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C
A
A
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C
T
C
A
G
A
G
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A
C
A
T
T
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C
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C
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A
C
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G
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1
4,951
C
C
A
C
T
G
C
C
G
T
G
G
A
G
A
C
G
C
C
T
G
A
G
C
C
A
G
T
T
G
C
T
C
C
C
A
C
C
A
C
A
G
C
A
A
T
C
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T
A
G
A
G
G
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A
A
T
G
T
G
C
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C
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T
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1
4,952
T
G
T
G
G
T
G
G
G
A
G
C
A
A
C
T
G
G
C
T
C
A
G
G
C
G
T
C
T
C
C
A
C
G
G
C
A
G
T
G
G
C
A
A
A
T
C
T
G
C
T
G
G
G
G
C
T
C
T
T
C
T
A
C
A
T
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0.031311
0.019569
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1
4,953
A
G
A
C
T
T
G
A
A
T
T
G
A
T
T
C
T
T
G
T
T
G
C
T
G
A
G
G
A
G
T
C
T
G
C
T
G
G
A
G
G
A
G
G
C
A
T
A
A
C
T
G
A
C
C
T
G
G
A
G
A
G
A
A
C
C
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0.013699
0.009785
0.062622
1
4,954
C
T
C
C
A
G
C
A
G
A
C
T
C
C
T
C
A
G
C
A
A
C
A
A
G
A
A
T
C
A
A
T
T
C
A
A
G
T
C
T
T
T
C
C
T
C
C
G
A
A
C
C
A
T
C
C
C
C
A
A
T
G
A
T
G
G
0.027397
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0.046967
0.013699
0.009785
0.064579
1
4,955
C
A
G
T
G
G
C
C
T
G
G
T
G
C
T
C
A
T
C
A
T
T
G
G
G
G
A
T
G
G
T
T
C
G
G
A
G
G
A
A
A
G
A
C
T
T
G
A
A
T
T
G
A
T
T
C
T
T
G
T
T
G
C
T
G
T
0.029354
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1
4,956
G
A
T
G
A
T
G
T
C
T
G
C
C
A
T
G
G
C
A
G
T
G
G
C
C
T
G
G
T
G
C
T
C
A
T
C
A
T
T
G
G
G
G
A
T
G
G
T
T
C
G
G
A
G
G
A
A
A
G
A
C
T
T
G
A
T
0.029354
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0.033268
0.046967
0.013699
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0.062622
1
4,957
A
C
T
G
G
G
T
G
G
G
C
A
C
A
A
T
T
G
C
A
G
C
T
G
A
T
G
A
C
G
A
C
T
A
T
G
G
G
C
G
G
C
C
G
G
G
G
A
T
T
G
A
G
A
A
A
T
T
C
C
G
A
G
A
G
G
0.019569
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0.046967
0.007828
0.001957
0.062622
1
4,958
T
G
G
G
C
A
C
A
A
T
T
G
C
A
G
C
T
G
A
T
G
A
C
G
A
C
T
A
T
G
G
G
C
G
G
C
C
G
G
G
G
A
T
T
G
A
G
A
A
A
T
T
C
C
G
A
G
A
G
G
A
A
G
C
T
T
0.019569
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0.048924
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0.062622
1
4,959
C
A
G
C
T
T
C
C
T
C
T
C
G
G
A
A
T
T
T
C
T
C
A
A
T
C
C
C
C
G
G
C
C
G
C
C
C
A
T
A
G
T
C
G
T
C
A
T
C
A
G
C
T
G
C
A
A
T
T
G
T
G
C
C
C
G
0.019569
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0.048924
0.007828
0.001957
0.062622
1
4,960
C
A
C
A
A
T
T
G
C
A
G
C
T
G
A
T
G
A
C
G
A
C
T
A
T
G
G
G
C
G
G
C
C
G
G
G
G
A
T
T
G
A
G
A
A
A
T
T
C
C
G
A
G
A
G
G
A
A
G
C
T
G
A
G
G
T
0.017613
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0.039139
0.017613
0.029354
0.052838
0.048924
0.007828
0.001957
0.062622
1
4,961
C
G
A
T
G
C
A
G
A
T
A
T
C
C
C
T
T
T
C
C
T
C
A
G
C
T
T
C
C
T
C
T
C
G
G
A
A
T
T
T
C
T
C
A
A
T
C
C
C
C
G
G
C
C
G
C
C
C
A
T
A
G
T
C
G
T
0.017613
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0.064579
1
4,962
C
G
A
T
G
C
A
G
A
T
A
T
C
C
C
T
T
T
C
C
T
C
A
G
C
T
T
C
C
T
C
T
C
G
G
A
A
T
T
T
C
T
C
A
A
T
C
C
C
C
G
G
C
C
G
C
C
C
A
T
A
G
T
C
G
A
0.017613
0.015656
0.027397
0.031311
0.011742
0.019569
0.007828
0.041096
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0.041096
0.017613
0.031311
0.050881
0.048924
0.011742
0.001957
0.064579
1
4,963
C
C
A
C
A
T
G
C
T
G
G
A
T
C
T
C
T
T
C
C
T
C
A
T
C
A
G
A
G
T
A
C
T
G
G
G
A
G
A
T
G
A
G
T
T
C
A
C
T
G
A
A
G
T
C
G
A
T
G
C
A
G
A
T
A
C
0.017613
0.015656
0.029354
0.033268
0.009785
0.019569
0.011742
0.031311
0.043053
0.033268
0.039139
0.013699
0.054795
0.039139
0.035225
0.027397
0.060665
0.068493
0.033268
0.021526
0.021526
0.015656
0.003914
0.054795
0.041096
0.017613
0.033268
0.058708
0.050881
0.011742
0.001957
0.050881
1
4,964
C
A
T
G
G
C
G
A
T
C
A
G
G
G
A
G
G
A
G
C
T
G
G
C
C
C
A
G
G
C
C
T
C
G
C
T
G
G
C
C
A
G
C
C
A
G
A
T
C
T
T
G
C
C
C
G
T
G
A
T
A
T
T
G
C
T
0.035225
0.013699
0.04501
0.031311
0.013699
0.02544
0.013699
0.027397
0.04501
0.02544
0.048924
0.009785
0.046967
0.029354
0.033268
0.033268
0.052838
0.064579
0.031311
0.021526
0.019569
0.015656
0.003914
0.04501
0.048924
0.021526
0.027397
0.052838
0.056751
0.011742
0.005871
0.043053
1
4,965
G
G
G
C
T
C
C
C
C
C
T
C
A
A
T
G
A
T
C
C
C
T
T
T
C
C
T
G
G
T
C
C
C
T
G
C
C
A
G
G
C
A
G
T
C
T
C
G
G
C
T
G
C
A
G
T
T
G
G
A
G
A
A
G
G
T
0.033268
0.021526
0.037182
0.009785
0.056751
0.029354
0.003914
0.033268
0.035225
0.02544
0.060665
0.019569
0.021526
0.035225
0.033268
0.052838
0.064579
0.052838
0.060665
0.003914
0.003914
0
0.009785
0.043053
0.029354
0.031311
0.039139
0.041096
0.046967
0.017613
0.007828
0.039139
1
4,966
A
A
A
G
C
A
G
C
A
G
G
T
G
G
G
C
T
C
C
C
C
C
T
C
A
A
T
G
A
T
C
C
C
T
T
T
C
C
T
G
G
T
C
C
C
T
G
C
C
A
G
G
C
A
G
T
C
T
C
G
G
C
T
G
C
T
0.035225
0.023483
0.039139
0.011742
0.052838
0.029354
0.003914
0.033268
0.039139
0.02544
0.060665
0.015656
0.023483
0.033268
0.033268
0.050881
0.064579
0.052838
0.060665
0.003914
0.003914
0
0.011742
0.043053
0.031311
0.031311
0.035225
0.041096
0.046967
0.013699
0.009785
0.039139
1
4,967
C
A
T
T
G
G
A
C
C
A
G
A
A
G
T
C
A
T
C
T
G
G
G
C
A
C
T
T
G
T
T
A
C
A
G
G
C
A
C
T
G
G
C
A
T
C
T
G
T
A
A
A
A
T
G
T
C
C
C
A
G
T
G
A
A
T
0.062622
0.037182
0.023483
0.037182
0.064579
0.029354
0.005871
0.029354
0.037182
0.023483
0.031311
0.021526
0.02544
0.052838
0.037182
0.054795
0.041096
0.046967
0.027397
0.009785
0.011742
0.003914
0.011742
0.04501
0.033268
0.019569
0.037182
0.021526
0.037182
0.017613
0.027397
0.035225
1
4,968
C
A
T
T
G
G
A
C
C
A
G
A
A
G
T
C
A
T
C
T
G
G
G
C
A
C
T
T
G
T
T
A
C
A
G
G
C
A
C
T
G
G
C
A
T
C
T
G
T
A
A
A
A
T
G
T
C
C
C
A
G
T
G
A
A
A
0.062622
0.037182
0.023483
0.037182
0.064579
0.029354
0.005871
0.029354
0.037182
0.023483
0.031311
0.021526
0.02544
0.052838
0.037182
0.054795
0.041096
0.046967
0.027397
0.009785
0.011742
0.003914
0.011742
0.04501
0.033268
0.019569
0.037182
0.021526
0.037182
0.017613
0.027397
0.035225
1
4,969
G
A
T
C
C
C
A
A
A
G
G
G
C
T
C
C
G
T
C
C
A
C
G
A
C
A
G
A
A
A
C
T
C
G
A
T
C
T
C
C
T
T
G
G
C
A
A
T
G
C
A
G
G
A
G
G
T
G
T
G
G
T
T
C
T
T
0.054795
0.023483
0.027397
0.029354
0.054795
0.02544
0.011742
0.027397
0.035225
0.031311
0.035225
0.017613
0.027397
0.043053
0.033268
0.054795
0.048924
0.050881
0.033268
0.017613
0.015656
0.009785
0.007828
0.04501
0.031311
0.023483
0.039139
0.037182
0.041096
0.015656
0.015656
0.035225
1
4,970
G
G
A
G
A
T
C
G
A
G
T
T
T
C
T
G
T
C
G
T
G
G
A
C
G
G
A
G
C
C
C
T
T
T
G
G
G
A
T
C
G
C
A
C
T
C
A
C
C
C
T
C
T
T
T
G
C
C
G
T
G
C
T
G
G
C
0.048924
0.019569
0.027397
0.027397
0.050881
0.02544
0.011742
0.027397
0.039139
0.031311
0.037182
0.013699
0.031311
0.04501
0.033268
0.058708
0.050881
0.052838
0.029354
0.015656
0.013699
0.009785
0.007828
0.048924
0.029354
0.021526
0.046967
0.037182
0.043053
0.015656
0.013699
0.035225
1
4,971
T
T
C
T
G
T
C
G
T
G
G
A
C
G
G
A
G
C
C
C
T
T
T
G
G
G
A
T
C
G
C
A
C
T
C
A
C
C
C
T
C
T
T
T
G
C
C
G
T
G
C
T
G
G
G
C
A
T
T
T
T
C
C
T
G
G
0.050881
0.023483
0.027397
0.02544
0.048924
0.029354
0.011742
0.027397
0.039139
0.031311
0.037182
0.011742
0.029354
0.043053
0.033268
0.058708
0.050881
0.054795
0.029354
0.017613
0.013699
0.009785
0.007828
0.048924
0.031311
0.021526
0.046967
0.037182
0.043053
0.013699
0.009785
0.035225
1
4,972
G
C
G
C
A
G
G
C
G
G
C
A
C
G
T
C
C
A
G
T
C
C
T
G
G
G
G
C
T
C
C
C
C
G
A
T
G
A
A
G
A
A
C
A
G
G
G
A
G
C
T
G
G
A
G
A
A
G
C
A
G
C
A
G
A
T
0.02544
0.027397
0.033268
0.009785
0.031311
0.043053
0.015656
0.013699
0.041096
0.04501
0.050881
0.001957
0.031311
0.027397
0.039139
0.050881
0.060665
0.056751
0.041096
0.02544
0.013699
0.019569
0.005871
0.050881
0.029354
0.021526
0.058708
0.041096
0.048924
0.005871
0.001957
0.031311
1
4,973
G
C
G
C
A
G
G
C
G
G
C
A
C
G
T
C
C
A
G
T
C
C
T
G
G
G
G
C
T
C
C
C
C
G
A
T
G
A
A
G
A
A
C
A
G
G
G
A
G
C
T
G
G
A
G
A
A
G
C
A
G
C
A
G
A
G
0.02544
0.027397
0.033268
0.009785
0.031311
0.043053
0.015656
0.013699
0.041096
0.04501
0.050881
0.001957
0.031311
0.027397
0.039139
0.050881
0.060665
0.056751
0.041096
0.02544
0.013699
0.019569
0.005871
0.050881
0.029354
0.021526
0.058708
0.041096
0.048924
0.005871
0.001957
0.031311
1
4,974
G
G
C
G
C
A
G
G
C
G
G
C
A
C
G
T
C
C
A
G
T
C
C
T
G
G
G
G
C
T
C
C
C
C
G
A
T
G
A
A
G
A
A
C
A
G
G
G
A
G
C
T
G
G
A
G
A
A
G
C
A
G
C
A
G
T
0.02544
0.027397
0.033268
0.009785
0.031311
0.043053
0.015656
0.013699
0.041096
0.04501
0.050881
0.001957
0.031311
0.027397
0.039139
0.048924
0.060665
0.056751
0.041096
0.02544
0.013699
0.019569
0.005871
0.052838
0.029354
0.021526
0.058708
0.041096
0.048924
0.005871
0.001957
0.031311
1
4,975
A
T
G
C
A
G
A
G
C
A
C
G
A
A
G
C
T
G
A
T
G
C
C
A
A
A
G
G
C
C
G
G
C
T
G
G
C
G
C
A
G
G
C
G
G
C
A
C
G
T
C
C
A
G
T
C
C
T
G
G
G
G
C
T
C
A
0.02544
0.02544
0.033268
0.007828
0.029354
0.037182
0.021526
0.011742
0.039139
0.048924
0.052838
0.001957
0.039139
0.029354
0.037182
0.050881
0.058708
0.052838
0.039139
0.02544
0.013699
0.019569
0.005871
0.054795
0.027397
0.017613
0.058708
0.041096
0.050881
0.005871
0.001957
0.035225
1
4,976
C
A
A
G
T
G
G
T
G
G
G
G
G
C
T
C
A
A
C
C
T
G
C
A
G
T
T
C
C
T
G
C
T
G
G
T
T
T
T
C
C
T
C
T
G
C
A
C
C
T
T
C
A
T
G
C
A
G
A
T
T
G
T
C
A
A
0.013699
0.021526
0.04501
0.005871
0.017613
0.035225
0.015656
0.011742
0.041096
0.062622
0.054795
0
0.037182
0.037182
0.031311
0.037182
0.064579
0.050881
0.037182
0.029354
0.009785
0.015656
0.007828
0.052838
0.041096
0.013699
0.056751
0.052838
0.046967
0.007828
0
0.04501
1
4,977
G
A
T
G
A
C
A
A
T
C
T
G
C
A
T
G
A
A
G
G
T
G
C
A
G
A
G
G
A
A
A
A
C
C
A
G
C
A
G
G
A
A
C
T
G
C
A
G
G
T
T
G
A
G
C
C
C
C
C
A
C
C
A
C
T
A
0.013699
0.021526
0.04501
0.003914
0.017613
0.035225
0.015656
0.011742
0.041096
0.062622
0.054795
0
0.037182
0.039139
0.029354
0.037182
0.064579
0.050881
0.037182
0.029354
0.009785
0.015656
0.007828
0.052838
0.041096
0.013699
0.056751
0.052838
0.046967
0.007828
0
0.046967
1
4,978
G
A
T
C
A
G
G
A
A
G
C
C
C
A
G
G
G
C
C
A
T
G
A
G
G
G
A
G
C
C
C
T
C
G
T
G
G
C
A
C
G
T
G
A
T
G
A
A
G
A
T
G
A
T
C
T
C
A
T
C
C
T
C
C
A
G
0.017613
0.019569
0.048924
0.007828
0.015656
0.033268
0.017613
0.011742
0.041096
0.058708
0.046967
0.003914
0.046967
0.048924
0.035225
0.039139
0.062622
0.056751
0.02544
0.02544
0.007828
0.011742
0.011742
0.035225
0.041096
0.011742
0.064579
0.058708
0.037182
0.007828
0
0.048924
1
4,979
C
A
T
C
A
C
G
T
G
C
C
A
C
G
A
G
G
G
C
T
C
C
C
T
C
A
T
G
G
C
C
C
T
G
G
G
C
T
T
C
C
T
G
A
T
C
G
G
C
T
A
C
A
C
C
T
G
C
C
T
G
C
T
G
G
G
0.015656
0.021526
0.050881
0.007828
0.017613
0.033268
0.017613
0.011742
0.048924
0.054795
0.04501
0.003914
0.050881
0.046967
0.037182
0.039139
0.060665
0.054795
0.02544
0.021526
0.007828
0.011742
0.013699
0.035225
0.04501
0.011742
0.062622
0.050881
0.037182
0.009785
0
0.048924
1
4,980
T
C
G
G
C
T
A
C
A
C
C
T
G
C
C
T
G
C
T
G
G
C
T
G
C
C
A
T
C
T
G
C
T
T
C
T
T
C
T
T
T
G
C
C
T
T
C
A
A
G
T
C
C
C
G
G
A
A
G
C
T
G
C
C
G
C
0.011742
0.019569
0.054795
0.009785
0.019569
0.031311
0.013699
0.011742
0.048924
0.054795
0.046967
0.003914
0.052838
0.046967
0.039139
0.037182
0.056751
0.054795
0.027397
0.021526
0.009785
0.015656
0.013699
0.037182
0.04501
0.009785
0.056751
0.052838
0.037182
0.009785
0
0.048924
1
4,981
C
G
G
C
T
A
C
A
C
C
T
G
C
C
T
G
C
T
G
G
C
T
G
C
C
A
T
C
T
G
C
T
T
C
T
T
C
T
T
T
G
C
C
T
T
C
A
A
G
T
C
C
C
G
G
A
A
G
C
T
G
C
C
G
G
G
0.011742
0.019569
0.054795
0.009785
0.019569
0.031311
0.015656
0.011742
0.048924
0.054795
0.04501
0.003914
0.052838
0.046967
0.039139
0.037182
0.056751
0.054795
0.027397
0.021526
0.009785
0.015656
0.013699
0.037182
0.04501
0.009785
0.056751
0.052838
0.037182
0.009785
0
0.048924
1
4,982
G
G
C
T
A
C
A
C
C
T
G
C
C
T
G
C
T
G
G
C
T
G
C
C
A
T
C
T
G
C
T
T
C
T
T
C
T
T
T
G
C
C
T
T
C
A
A
G
T
C
C
C
G
G
A
A
G
C
T
G
C
C
G
G
A
G
0.011742
0.021526
0.054795
0.009785
0.019569
0.031311
0.015656
0.011742
0.048924
0.054795
0.04501
0.003914
0.052838
0.046967
0.039139
0.037182
0.056751
0.054795
0.027397
0.021526
0.009785
0.015656
0.013699
0.035225
0.04501
0.009785
0.056751
0.052838
0.037182
0.009785
0
0.048924
1
4,983
A
G
G
A
G
A
T
C
C
A
G
A
C
G
A
T
G
A
A
G
A
A
G
A
T
G
A
G
C
A
T
G
C
T
G
A
A
G
G
T
G
A
T
G
A
A
C
T
T
G
G
C
T
T
C
A
T
T
G
A
A
G
T
T
C
T
0.011742
0.017613
0.052838
0.009785
0.017613
0.02544
0.023483
0.007828
0.048924
0.062622
0.041096
0.003914
0.048924
0.046967
0.037182
0.035225
0.058708
0.04501
0.021526
0.027397
0.009785
0.02544
0.013699
0.035225
0.04501
0.011742
0.066536
0.056751
0.033268
0.009785
0
0.048924
1
4,984
C
A
G
C
A
T
G
C
T
C
A
T
C
T
T
C
T
T
C
A
T
C
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G
G
A
T
C
T
C
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T
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C
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T
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C
C
A
G
C
C
T
A
T
G
C
C
A
G
C
A
C
C
T
A
T
G
G
C
A
T
0.007828
0.015656
0.054795
0.009785
0.017613
0.023483
0.023483
0.007828
0.046967
0.068493
0.039139
0.003914
0.048924
0.043053
0.041096
0.033268
0.056751
0.046967
0.023483
0.031311
0.009785
0.029354
0.013699
0.037182
0.039139
0.013699
0.060665
0.060665
0.035225
0.009785
0
0.046967
1
4,985
T
G
T
C
T
C
T
G
C
C
G
T
A
G
A
G
G
T
G
A
T
T
G
C
C
A
T
C
C
T
G
G
C
A
G
C
C
A
G
C
T
T
T
G
G
C
T
T
G
C
T
G
G
C
G
T
G
C
A
T
C
T
T
C
T
A
0.007828
0.015656
0.056751
0.009785
0.013699
0.021526
0.023483
0.007828
0.043053
0.068493
0.041096
0.003914
0.046967
0.04501
0.039139
0.033268
0.054795
0.050881
0.031311
0.029354
0.013699
0.023483
0.009785
0.041096
0.043053
0.011742
0.064579
0.058708
0.041096
0.005871
0
0.043053
1
4,986
G
C
A
C
C
G
C
A
G
C
T
C
A
C
G
C
T
T
T
C
A
A
G
G
T
G
G
C
T
G
C
C
C
G
G
G
C
C
A
C
G
C
T
G
C
G
C
C
G
C
A
G
C
A
A
C
G
T
C
T
C
C
C
G
C
T
0.007828
0.017613
0.050881
0.009785
0.013699
0.02544
0.019569
0.003914
0.04501
0.088063
0.037182
0.003914
0.039139
0.037182
0.043053
0.027397
0.076321
0.050881
0.035225
0.023483
0.011742
0.027397
0.009785
0.039139
0.033268
0.013699
0.084149
0.050881
0.033268
0.003914
0.001957
0.035225
1
4,987
T
G
C
G
G
G
A
G
A
C
G
T
T
G
C
T
G
C
G
G
C
G
C
A
G
C
G
T
G
G
C
C
C
G
G
G
C
A
G
C
C
A
C
C
T
T
G
A
A
A
G
C
G
T
G
A
G
C
T
G
C
G
G
T
G
G
0.007828
0.017613
0.048924
0.009785
0.013699
0.02544
0.019569
0.003914
0.04501
0.088063
0.037182
0.003914
0.039139
0.037182
0.043053
0.027397
0.076321
0.050881
0.035225
0.023483
0.011742
0.027397
0.009785
0.039139
0.033268
0.013699
0.084149
0.052838
0.033268
0.003914
0.001957
0.035225
1
4,988
T
G
C
T
G
G
C
T
G
C
C
A
A
C
A
C
G
T
A
C
C
A
G
C
T
G
G
A
G
T
G
C
C
G
G
G
G
C
G
T
G
G
T
C
A
A
G
G
T
C
A
A
G
G
G
C
A
A
A
G
G
C
G
A
G
T
0.011742
0.013699
0.031311
0.005871
0.031311
0.029354
0.007828
0.019569
0.037182
0.066536
0.056751
0
0.011742
0.029354
0.02544
0.039139
0.09002
0.07045
0.062622
0.017613
0.001957
0.019569
0.007828
0.050881
0.021526
0.023483
0.052838
0.080235
0.037182
0.011742
0.003914
0.031311
1
4,989
T
T
T
C
T
C
T
C
A
G
G
C
C
A
C
A
G
A
G
G
A
G
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G
A
G
A
T
G
G
A
G
G
A
G
C
T
G
C
A
G
G
C
C
T
A
C
A
A
C
C
G
G
C
G
G
C
T
G
C
A
0.033268
0.023483
0.027397
0.011742
0.037182
0.017613
0.013699
0.031311
0.050881
0.037182
0.050881
0.001957
0.02544
0.031311
0.039139
0.037182
0.052838
0.043053
0.019569
0.02544
0.021526
0.029354
0.011742
0.078278
0.02544
0.02544
0.041096
0.060665
0.043053
0.013699
0
0.039139
1
4,990
G
C
C
C
A
G
C
A
G
G
T
G
G
A
G
T
C
C
A
C
T
G
C
C
C
G
C
C
T
C
G
A
C
T
T
C
C
T
C
T
G
G
A
A
A
C
T
G
C
A
G
G
T
G
G
G
T
G
G
C
C
C
T
G
G
A
0.019569
0.013699
0.035225
0.003914
0.029354
0.039139
0.013699
0.02544
0.031311
0.041096
0.064579
0.005871
0.009785
0.019569
0.027397
0.050881
0.076321
0.07045
0.080235
0.015656
0.011742
0.009785
0.001957
0.048924
0.017613
0.035225
0.048924
0.068493
0.043053
0.009785
0.005871
0.02544
1
4,991
C
C
G
T
C
T
C
A
G
G
C
C
T
G
T
C
C
A
C
C
A
C
C
T
C
C
C
C
A
C
A
G
C
C
C
T
G
A
G
C
A
T
G
C
A
A
C
C
A
A
G
G
T
G
G
C
A
T
T
G
A
A
G
G
T
A
0.015656
0.011742
0.035225
0.005871
0.023483
0.037182
0.017613
0.019569
0.029354
0.046967
0.074364
0.005871
0.009785
0.017613
0.02544
0.04501
0.080235
0.064579
0.072407
0.015656
0.007828
0.017613
0.001957
0.050881
0.019569
0.029354
0.052838
0.074364
0.04501
0.011742
0.007828
0.027397
1
4,992
G
T
G
C
T
C
A
G
A
C
C
G
A
A
G
C
C
T
A
T
C
A
A
T
G
C
T
C
C
T
G
G
C
G
T
C
A
A
T
G
G
C
A
C
G
G
C
C
C
A
G
A
A
A
C
T
C
A
T
C
C
A
C
T
T
T
0.007828
0.021526
0.031311
0.005871
0.015656
0.031311
0.017613
0.021526
0.046967
0.050881
0.074364
0.001957
0.017613
0.021526
0.011742
0.035225
0.080235
0.046967
0.066536
0.017613
0.009785
0.013699
0.015656
0.066536
0.039139
0.02544
0.04501
0.054795
0.052838
0.005871
0.007828
0.039139
1
4,993
G
C
C
A
G
C
C
T
C
C
A
T
G
T
G
G
T
T
G
G
C
T
A
G
C
G
T
G
A
C
A
T
C
G
T
T
A
G
A
C
C
A
G
A
C
G
T
C
G
A
A
C
T
G
C
C
A
C
T
T
C
C
T
G
A
T
0.007828
0.017613
0.029354
0.011742
0.031311
0.050881
0.015656
0.02544
0.029354
0.037182
0.054795
0
0.011742
0.021526
0.02544
0.068493
0.062622
0.072407
0.080235
0.017613
0.011742
0.021526
0.013699
0.041096
0.031311
0.027397
0.04501
0.052838
0.041096
0.009785
0.003914
0.029354
1
4,994
T
G
C
C
T
G
T
C
C
C
C
C
A
G
C
A
T
C
C
T
G
T
T
T
G
C
T
G
A
C
A
T
C
G
A
G
G
G
C
T
T
C
A
C
C
A
G
C
C
T
G
G
C
G
T
C
C
C
A
G
T
G
C
A
C
G
0.039139
0.013699
0.035225
0.009785
0.027397
0.033268
0.003914
0.023483
0.033268
0.056751
0.064579
0.013699
0.021526
0.021526
0.029354
0.033268
0.078278
0.04501
0.068493
0.009785
0.015656
0.009785
0.013699
0.050881
0.021526
0.031311
0.048924
0.050881
0.035225
0.011742
0.007828
0.041096
1
4,995
C
C
T
G
C
T
G
C
T
G
G
T
T
C
T
C
C
C
G
C
T
G
C
G
A
G
T
G
G
A
G
C
C
G
C
G
C
C
T
G
G
A
T
G
C
A
C
T
C
T
C
G
G
G
T
C
T
C
C
T
G
G
A
A
A
T
0.015656
0.015656
0.017613
0.011742
0.027397
0.031311
0.009785
0.02544
0.037182
0.050881
0.058708
0.005871
0.011742
0.02544
0.019569
0.048924
0.07045
0.056751
0.076321
0.023483
0.009785
0.019569
0.017613
0.068493
0.021526
0.021526
0.052838
0.060665
0.046967
0.007828
0.003914
0.029354
1
4,996
C
T
T
T
C
C
A
G
G
A
G
A
C
C
C
G
A
G
A
G
T
G
C
A
T
C
C
A
G
G
C
G
C
G
G
C
T
C
C
A
C
T
C
G
C
A
G
C
G
G
G
A
G
A
A
C
C
A
G
C
A
G
C
A
G
T
0.015656
0.015656
0.017613
0.011742
0.027397
0.031311
0.009785
0.02544
0.037182
0.050881
0.058708
0.005871
0.011742
0.02544
0.021526
0.048924
0.07045
0.056751
0.076321
0.023483
0.009785
0.019569
0.015656
0.068493
0.021526
0.021526
0.052838
0.060665
0.046967
0.007828
0.003914
0.029354
1
4,997
C
G
T
C
G
G
A
C
A
A
A
C
T
G
G
A
G
C
G
G
C
T
G
T
A
C
C
A
G
C
G
C
T
A
C
T
T
C
T
T
C
C
G
C
C
T
G
A
A
C
C
A
G
A
G
C
A
G
C
C
T
C
A
C
C
C
0.003914
0.011742
0.015656
0.001957
0.013699
0.035225
0.02544
0.007828
0.009785
0.058708
0.046967
0.005871
0.011742
0.027397
0.013699
0.037182
0.056751
0.060665
0.050881
0.078278
0.027397
0.09002
0.005871
0.043053
0.015656
0.02544
0.04501
0.107632
0.043053
0.007828
0
0.015656
1
4,998
T
T
T
T
G
C
T
G
A
A
T
A
T
G
C
C
T
T
G
A
A
G
A
A
C
T
T
C
C
C
T
G
C
C
C
A
G
A
C
T
T
T
T
C
G
A
G
T
T
T
T
C
T
T
T
T
C
T
A
C
A
A
G
T
C
A
0.058708
0.019569
0.048924
0.017613
0.033268
0.021526
0.007828
0.029354
0.043053
0.043053
0.041096
0.019569
0.017613
0.037182
0.031311
0.041096
0.056751
0.066536
0.050881
0.005871
0.009785
0.003914
0.019569
0.031311
0.035225
0.019569
0.050881
0.054795
0.037182
0.011742
0.019569
0.015656
1
4,999
A
A
T
T
T
T
T
T
C
T
T
T
T
C
T
A
G
G
A
A
C
T
A
A
G
C
G
T
C
T
T
G
T
A
G
A
A
G
G
A
A
C
T
A
T
T
A
A
T
C
C
A
G
G
A
G
A
A
A
C
C
T
G
T
T
G
0.062622
0.039139
0.033268
0.041096
0.068493
0.013699
0.009785
0.048924
0.035225
0.021526
0.02544
0.074364
0.023483
0.029354
0.048924
0.033268
0.048924
0.031311
0.005871
0.003914
0.003914
0.009785
0.021526
0.027397
0.033268
0.013699
0.035225
0.015656
0.031311
0.054795
0.029354
0.02544
1
5,000
G
G
G
A
C
A
T
A
T
T
C
T
C
C
C
A
G
G
G
A
T
T
T
G
G
G
C
C
T
T
T
C
C
G
C
T
G
G
G
T
G
T
G
C
A
C
A
T
C
G
G
G
G
G
A
C
C
C
C
C
A
G
G
A
C
T
0.011742
0.011742
0.02544
0.013699
0.041096
0.035225
0.003914
0.011742
0.033268
0.050881
0.060665
0.009785
0.019569
0.035225
0.023483
0.046967
0.072407
0.074364
0.101761
0.007828
0.003914
0.011742
0.019569
0.041096
0.023483
0.029354
0.041096
0.052838
0.054795
0.005871
0.003914
0.021526
1
5,001
G
C
T
G
G
C
C
C
C
A
G
A
G
T
T
T
G
C
C
C
A
G
G
A
G
C
T
G
C
A
A
C
T
G
T
A
C
G
G
A
C
A
C
A
T
C
T
A
C
A
T
G
T
A
C
C
G
G
T
T
T
T
G
C
C
C
0.015656
0.017613
0.017613
0.009785
0.039139
0.023483
0.005871
0.023483
0.035225
0.048924
0.060665
0
0.013699
0.019569
0.021526
0.021526
0.084149
0.050881
0.09002
0.035225
0.015656
0.02544
0.007828
0.058708
0.023483
0.033268
0.037182
0.064579
0.058708
0.019569
0
0.021526
1
5,002
T
G
C
C
T
C
C
A
T
A
C
T
T
G
G
C
C
C
G
G
A
T
T
C
G
G
G
G
T
T
C
A
C
G
G
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C
A
G
T
G
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C
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G
G
T
T
G
G
T
G
C
C
T
G
T
G
A
C
C
G
T
C
T
0.013699
0.015656
0.029354
0.007828
0.023483
0.048924
0.013699
0.013699
0.017613
0.046967
0.078278
0.007828
0.007828
0.015656
0.023483
0.04501
0.078278
0.068493
0.093933
0.027397
0.003914
0.005871
0.009785
0.037182
0.02544
0.02544
0.048924
0.074364
0.050881
0.013699
0.003914
0.023483
1
5,003
G
G
C
G
T
A
C
T
G
A
T
G
C
C
C
T
C
A
C
C
T
C
C
A
G
C
C
C
T
G
G
C
C
G
T
G
A
C
C
T
T
C
C
A
C
C
A
T
T
T
G
A
G
G
A
T
G
A
G
T
C
C
G
A
G
T
0.02544
0.011742
0.041096
0.021526
0.021526
0.031311
0.005871
0.009785
0.039139
0.043053
0.076321
0.003914
0.035225
0.041096
0.029354
0.031311
0.052838
0.056751
0.043053
0.019569
0.013699
0.007828
0.009785
0.064579
0.039139
0.015656
0.033268
0.060665
0.058708
0.009785
0.003914
0.043053
1
5,004
G
G
G
A
T
C
A
T
G
T
C
T
T
C
A
G
A
T
T
C
A
G
C
T
G
A
C
C
C
T
T
T
C
T
A
T
T
G
G
A
T
G
A
G
A
G
T
G
A
T
T
C
T
A
G
C
C
T
C
T
A
A
C
A
G
A
0.052838
0.02544
0.050881
0.050881
0.035225
0.017613
0.001957
0.041096
0.054795
0.046967
0.039139
0.033268
0.021526
0.021526
0.033268
0.029354
0.048924
0.029354
0.023483
0.001957
0.001957
0.001957
0.037182
0.04501
0.048924
0.013699
0.027397
0.021526
0.031311
0.02544
0.04501
0.041096
1
5,005
A
G
A
T
T
C
A
G
C
T
G
A
C
C
C
T
T
T
C
T
A
T
T
G
G
A
T
G
A
G
A
G
T
G
A
T
T
C
T
A
G
C
C
T
C
T
A
A
C
A
G
A
G
G
T
A
G
G
A
C
T
C
T
G
G
G
0.046967
0.02544
0.052838
0.046967
0.035225
0.017613
0.001957
0.041096
0.058708
0.04501
0.039139
0.035225
0.023483
0.023483
0.031311
0.029354
0.048924
0.029354
0.023483
0.001957
0.001957
0.001957
0.037182
0.046967
0.048924
0.013699
0.02544
0.021526
0.031311
0.027397
0.04501
0.041096
1
5,006
T
G
C
C
T
T
C
C
A
T
A
C
G
A
T
G
G
T
T
T
C
A
C
A
G
A
T
G
T
T
A
G
T
T
G
C
A
A
T
G
A
A
G
A
G
A
G
A
A
A
T
A
C
C
A
G
A
G
C
C
A
A
G
G
C
C
0.076321
0.033268
0.039139
0.04501
0.043053
0.021526
0.009785
0.02544
0.04501
0.037182
0.031311
0.027397
0.02544
0.035225
0.043053
0.021526
0.052838
0.039139
0.033268
0.009785
0.005871
0.005871
0.013699
0.033268
0.039139
0.021526
0.031311
0.029354
0.029354
0.023483
0.033268
0.039139
1
5,007
C
C
A
T
G
A
A
G
A
A
G
G
A
A
G
G
G
A
T
C
C
A
G
A
C
T
C
G
G
A
A
C
C
G
G
A
A
G
A
T
G
T
C
C
A
A
C
A
A
G
T
C
C
A
A
G
A
A
G
A
G
C
A
A
G
T
0.007828
0.019569
0.039139
0.007828
0.02544
0.043053
0.005871
0.023483
0.02544
0.035225
0.064579
0.005871
0.015656
0.041096
0.017613
0.04501
0.058708
0.078278
0.068493
0.027397
0.011742
0.013699
0.011742
0.039139
0.04501
0.033268
0.033268
0.054795
0.07045
0.001957
0.003914
0.02544
1
5,008
T
C
T
T
C
T
T
G
G
A
C
T
T
G
T
T
G
G
A
C
A
T
C
T
T
C
C
G
G
T
T
C
C
G
A
G
T
C
T
G
G
A
T
C
C
C
T
T
C
C
T
T
C
T
T
C
A
T
G
G
T
C
A
G
T
T
0.007828
0.017613
0.039139
0.007828
0.02544
0.043053
0.005871
0.023483
0.027397
0.037182
0.062622
0.005871
0.015656
0.041096
0.017613
0.04501
0.060665
0.078278
0.066536
0.027397
0.011742
0.013699
0.011742
0.041096
0.043053
0.033268
0.033268
0.056751
0.068493
0.001957
0.003914
0.02544
1
5,009
C
G
T
T
G
C
A
G
A
C
A
G
G
G
T
C
C
C
C
G
T
T
G
G
C
G
T
T
T
C
G
G
C
G
C
C
A
T
A
A
G
G
T
G
G
T
G
G
T
T
G
T
C
G
T
C
T
G
A
C
A
A
T
T
T
A
0.019569
0.015656
0.037182
0.021526
0.027397
0.029354
0.015656
0.019569
0.033268
0.052838
0.054795
0.007828
0.007828
0.013699
0.039139
0.039139
0.062622
0.056751
0.076321
0.021526
0.013699
0.031311
0.011742
0.048924
0.023483
0.031311
0.041096
0.066536
0.035225
0.005871
0.009785
0.029354
1
5,010
C
G
T
T
G
C
A
G
A
C
A
G
G
G
T
C
C
C
C
G
T
T
G
G
C
G
T
T
T
C
G
G
C
G
C
C
A
T
A
A
G
G
T
G
G
T
G
G
T
T
G
T
C
G
T
C
T
G
A
C
A
A
T
T
T
T
0.019569
0.015656
0.037182
0.021526
0.027397
0.029354
0.015656
0.019569
0.033268
0.052838
0.054795
0.007828
0.007828
0.013699
0.039139
0.039139
0.062622
0.056751
0.076321
0.021526
0.013699
0.031311
0.011742
0.048924
0.023483
0.031311
0.041096
0.066536
0.035225
0.005871
0.009785
0.029354
1
5,011
C
T
G
T
T
G
T
G
C
A
A
A
T
T
G
T
C
A
G
A
C
G
A
C
A
A
C
C
A
C
C
A
C
C
T
T
A
T
G
G
C
G
C
C
G
A
A
A
C
G
C
C
A
A
C
G
G
G
G
A
C
C
C
T
G
A
0.021526
0.015656
0.039139
0.023483
0.02544
0.029354
0.015656
0.019569
0.033268
0.050881
0.050881
0.009785
0.007828
0.013699
0.041096
0.039139
0.060665
0.058708
0.076321
0.021526
0.013699
0.031311
0.007828
0.048924
0.02544
0.029354
0.041096
0.066536
0.035225
0.005871
0.011742
0.029354
1
5,012
A
A
G
A
G
C
C
G
G
C
A
C
C
T
G
T
T
G
T
G
C
A
A
A
T
T
G
T
C
A
G
A
C
G
A
C
A
A
C
C
A
C
C
A
C
C
T
T
A
T
G
G
C
G
C
C
G
A
A
A
C
G
C
C
A
T
0.021526
0.017613
0.041096
0.023483
0.02544
0.027397
0.015656
0.021526
0.039139
0.046967
0.048924
0.009785
0.007828
0.013699
0.041096
0.037182
0.060665
0.054795
0.076321
0.021526
0.013699
0.031311
0.007828
0.048924
0.029354
0.029354
0.041096
0.064579
0.033268
0.005871
0.011742
0.031311
1
5,013
G
G
C
G
T
T
T
C
G
G
C
G
C
C
A
T
A
A
G
G
T
G
G
T
G
G
T
T
G
T
C
G
T
C
T
G
A
C
A
A
T
T
T
G
C
A
C
A
A
C
A
G
G
T
G
C
C
G
G
C
T
C
T
T
C
G
0.021526
0.017613
0.041096
0.023483
0.02544
0.027397
0.015656
0.021526
0.039139
0.048924
0.048924
0.009785
0.007828
0.013699
0.041096
0.037182
0.060665
0.054795
0.076321
0.021526
0.013699
0.031311
0.007828
0.048924
0.029354
0.029354
0.041096
0.064579
0.031311
0.005871
0.011742
0.031311
1
5,014
C
T
G
C
C
C
A
T
T
C
A
T
C
T
T
G
T
G
G
T
A
G
A
G
G
C
C
A
C
A
G
G
C
A
T
T
G
C
A
C
A
G
G
T
A
G
T
G
G
C
C
G
G
T
G
C
C
G
T
C
C
C
G
C
C
T
0.031311
0.019569
0.031311
0.015656
0.029354
0.027397
0.011742
0.021526
0.04501
0.037182
0.054795
0.001957
0.013699
0.019569
0.023483
0.039139
0.07045
0.054795
0.066536
0.039139
0.013699
0.013699
0.005871
0.050881
0.031311
0.023483
0.048924
0.080235
0.039139
0.007828
0.011742
0.019569
1
5,015
T
C
C
C
A
T
T
T
G
T
T
G
T
G
T
T
G
G
G
A
A
A
C
A
A
G
A
T
T
G
A
C
C
T
C
G
A
A
A
A
C
A
G
A
C
A
A
G
T
A
A
G
T
A
C
C
A
A
C
G
A
T
G
A
T
T
0.029354
0.031311
0.031311
0.023483
0.048924
0.035225
0.005871
0.023483
0.050881
0.037182
0.04501
0.017613
0.023483
0.033268
0.037182
0.033268
0.066536
0.056751
0.050881
0.009785
0.009785
0.001957
0.019569
0.041096
0.033268
0.037182
0.029354
0.037182
0.039139
0.011742
0.013699
0.035225
1
5,016
G
T
C
T
G
G
A
A
C
G
C
C
T
G
C
T
C
C
A
C
G
T
T
G
A
T
G
G
C
C
T
C
C
T
T
G
G
C
A
C
T
G
G
T
C
T
C
A
A
A
G
T
A
G
G
G
A
A
T
G
T
T
G
T
T
A
0.023483
0.019569
0.041096
0.015656
0.041096
0.035225
0.013699
0.02544
0.039139
0.041096
0.056751
0.021526
0.013699
0.035225
0.021526
0.04501
0.07045
0.056751
0.050881
0.005871
0.003914
0.003914
0.021526
0.031311
0.037182
0.035225
0.04501
0.039139
0.04501
0.015656
0.019569
0.029354
1
5,017
T
C
C
G
T
G
C
A
A
T
C
G
T
C
T
G
G
A
A
C
G
C
C
T
G
C
T
C
C
A
C
G
T
T
G
A
T
G
G
C
C
T
C
C
T
T
G
G
C
A
C
T
G
G
T
C
T
C
A
A
A
G
T
A
G
A
0.027397
0.019569
0.043053
0.015656
0.041096
0.035225
0.013699
0.02544
0.043053
0.035225
0.056751
0.019569
0.015656
0.035225
0.021526
0.04501
0.07045
0.056751
0.050881
0.005871
0.003914
0.003914
0.017613
0.031311
0.037182
0.035225
0.046967
0.039139
0.04501
0.015656
0.019569
0.027397
1
5,018
A
T
T
C
C
G
T
G
C
A
A
T
C
G
T
C
T
G
G
A
A
C
G
C
C
T
G
C
T
C
C
A
C
G
T
T
G
A
T
G
G
C
C
T
C
C
T
T
G
G
C
A
C
T
G
G
T
C
T
C
A
A
A
G
T
T
0.027397
0.019569
0.043053
0.015656
0.041096
0.035225
0.013699
0.02544
0.043053
0.033268
0.058708
0.019569
0.015656
0.035225
0.021526
0.04501
0.07045
0.056751
0.050881
0.005871
0.003914
0.003914
0.015656
0.031311
0.037182
0.035225
0.046967
0.041096
0.04501
0.015656
0.019569
0.027397
1
5,019
C
G
T
G
G
T
G
C
G
C
A
G
G
A
A
G
A
G
C
C
C
G
C
A
G
C
C
G
C
T
C
A
T
G
C
T
G
C
C
C
G
A
T
G
T
T
C
C
C
C
A
G
C
C
T
C
A
G
C
C
T
C
A
G
T
A
0.019569
0.017613
0.035225
0.003914
0.021526
0.031311
0.031311
0.017613
0.033268
0.050881
0.046967
0
0.013699
0.011742
0.021526
0.039139
0.062622
0.037182
0.058708
0.046967
0.015656
0.074364
0.015656
0.035225
0.027397
0.02544
0.048924
0.076321
0.023483
0.019569
0.007828
0.029354
1
5,020
G
C
C
G
T
G
G
T
G
C
G
C
A
G
G
A
A
G
A
G
C
C
C
G
C
A
G
C
C
G
C
T
C
A
T
G
C
T
G
C
C
C
G
A
T
G
T
T
C
C
C
C
A
G
C
C
T
C
A
G
C
C
T
C
A
T
0.019569
0.017613
0.035225
0.003914
0.021526
0.031311
0.031311
0.017613
0.033268
0.050881
0.046967
0.001957
0.013699
0.011742
0.021526
0.039139
0.062622
0.035225
0.056751
0.046967
0.015656
0.074364
0.015656
0.035225
0.027397
0.02544
0.048924
0.076321
0.023483
0.021526
0.007828
0.029354
1
5,021
G
C
C
C
G
C
C
T
G
T
A
C
G
A
G
C
T
T
T
C
G
C
C
A
A
A
G
A
G
C
T
T
T
T
C
C
T
A
G
G
C
A
A
A
A
T
C
A
A
G
A
A
G
G
T
A
A
C
G
C
G
A
G
C
C
A
0.031311
0.027397
0.033268
0.009785
0.031311
0.037182
0.027397
0.019569
0.037182
0.046967
0.041096
0.001957
0.011742
0.011742
0.023483
0.043053
0.058708
0.037182
0.054795
0.043053
0.017613
0.054795
0.011742
0.041096
0.037182
0.027397
0.041096
0.048924
0.035225
0.017613
0.011742
0.027397
1
5,022
G
C
G
C
G
C
A
C
A
G
G
A
G
C
T
A
C
T
T
A
C
T
G
T
T
G
G
A
G
C
C
C
C
G
A
A
T
G
C
C
T
A
A
T
T
T
A
T
C
T
T
C
G
G
G
T
T
T
C
C
C
A
T
T
A
T
0.07045
0.019569
0.043053
0.035225
0.076321
0.017613
0.007828
0.039139
0.041096
0.031311
0.02544
0.013699
0.02544
0.023483
0.039139
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1
5,023
G
C
T
T
G
G
G
C
T
A
C
A
C
A
A
G
G
G
A
C
T
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A
C
A
C
C
C
G
C
A
T
C
C
T
C
C
T
C
A
T
C
A
0.009785
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0.064579
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0.005871
0.037182
1
5,024
A
G
G
C
C
T
G
G
G
A
G
G
G
C
C
T
G
G
T
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T
C
T
C
C
A
C
G
G
T
C
C
G
G
C
C
G
A
A
G
T
0.033268
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0.043053
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1
5,025
G
C
T
C
C
A
T
C
C
G
C
A
T
T
G
G
G
C
T
C
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A
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C
C
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A
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C
C
T
C
A
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A
C
A
G
G
G
G
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0.007828
0.041096
1
5,026
A
C
A
G
C
C
C
C
T
C
T
C
T
C
T
G
C
A
G
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A
G
C
C
C
T
G
T
T
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C
T
G
C
T
C
T
G
G
G
C
0.005871
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0
0.009785
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1
5,027
G
C
C
A
G
C
C
T
G
T
C
C
C
A
T
G
C
C
T
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G
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C
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A
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C
A
G
A
G
G
C
C
A
C
C
A
C
0.005871
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0
0.029354
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0
0.007828
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1
5,028
C
A
G
C
A
G
A
G
G
C
C
A
C
C
A
A
G
G
A
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G
G
A
A
A
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C
A
T
G
G
G
G
C
T
G
C
0.005871
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0
0.02544
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0.019569
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0.062622
0.088063
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0.005871
0
0.023483
1
5,029
C
A
G
G
C
A
G
G
G
C
C
G
T
G
A
G
T
C
C
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T
G
G
T
T
T
C
C
A
G
G
G
C
G
C
G
G
C
0.003914
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0
0.02544
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0.068493
0.097847
0.041096
0.005871
0
0.021526
1
5,030
C
C
T
G
C
C
T
G
C
C
C
T
G
C
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G
G
C
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A
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A
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T
C
A
G
T
C
C
G
T
G
C
C
0.003914
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0
0.027397
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0.072407
0.111546
0.033268
0.007828
0
0.017613
1
5,031
C
A
A
C
A
G
C
C
T
T
C
A
G
T
C
C
G
T
G
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G
C
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A
G
A
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C
C
T
C
G
A
T
G
C
0.003914
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0
0.027397
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0.031311
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0.068493
0.111546
0.029354
0.005871
0
0.015656
1
5,032
C
C
C
G
C
T
C
C
T
C
A
C
C
A
G
T
G
C
T
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G
C
C
C
T
C
A
T
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A
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G
C
T
T
C
C
C
T
G
0.021526
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0.072407
0.039139
0.013699
0.011742
0.021526
1
5,033
G
C
T
G
A
A
A
T
T
T
T
G
C
C
A
G
A
T
C
C
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G
C
T
A
T
C
G
T
C
C
T
G
C
T
G
A
A
G
C
G
0.033268
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0.031311
0.04501
0.048924
0.043053
0.007828
0.009785
0.041096
1
5,034
A
C
T
C
G
A
A
G
G
G
G
C
T
G
C
G
T
A
C
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T
A
G
G
G
C
C
T
T
C
T
C
0.005871
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0.019569
0.041096
0.050881
0.029354
0.023483
0.013699
0.043053
1
5,035
C
C
C
T
A
A
C
T
T
C
T
A
C
G
T
G
C
C
C
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C
C
C
C
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A
G
T
A
C
C
C
A
C
T
0.003914
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0.015656
0.021526
0.037182
0.023483
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0.060665
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0.04501
0.033268
0.019569
0.041096
0.050881
0.031311
0.02544
0.013699
0.043053
1
5,036
C
C
T
T
C
T
C
C
A
A
T
G
C
G
A
C
G
G
G
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C
T
G
A
G
G
0.003914
0.015656
0.035225
0.011742
0.021526
0.037182
0.02544
0.021526
0.037182
0.060665
0.046967
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0.04501
0.062622
0.062622
0.060665
0.011742
0.013699
0.015656
0.023483
0.04501
0.037182
0.021526
0.037182
0.054795
0.029354
0.02544
0.009785
0.043053
1
5,037
C
T
T
C
T
C
C
A
A
T
G
C
G
A
C
G
G
G
T
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T
G
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C
A
0.003914
0.015656
0.035225
0.011742
0.023483
0.037182
0.02544
0.021526
0.037182
0.060665
0.046967
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0.019569
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0.04501
0.062622
0.062622
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0.011742
0.013699
0.015656
0.023483
0.04501
0.037182
0.021526
0.037182
0.054795
0.029354
0.02544
0.009785
0.043053
1
5,038
C
T
T
C
T
C
C
A
A
T
G
C
G
A
C
G
G
G
T
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A
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T
G
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C
T
0.003914
0.015656
0.035225
0.011742
0.023483
0.037182
0.02544
0.021526
0.037182
0.060665
0.046967
0.007828
0.019569
0.039139
0.015656
0.04501
0.062622
0.062622
0.060665
0.011742
0.013699
0.015656
0.023483
0.04501
0.037182
0.021526
0.037182
0.054795
0.029354
0.02544
0.009785
0.043053
1
5,039
T
G
G
A
G
A
A
C
T
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C
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C
0.005871
0.013699
0.035225
0.013699
0.021526
0.035225
0.02544
0.021526
0.037182
0.060665
0.048924
0.005871
0.019569
0.039139
0.019569
0.043053
0.064579
0.064579
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0.011742
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0.015656
0.023483
0.046967
0.035225
0.021526
0.041096
0.054795
0.033268
0.02544
0.007828
0.039139
1
5,040
A
T
G
G
A
G
A
A
C
T
G
C
C
A
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G
G
C
T
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C
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G
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T
A
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A
0.005871
0.013699
0.035225
0.013699
0.021526
0.035225
0.02544
0.021526
0.037182
0.060665
0.050881
0.005871
0.019569
0.039139
0.019569
0.043053
0.064579
0.062622
0.054795
0.011742
0.013699
0.015656
0.023483
0.046967
0.035225
0.021526
0.041096
0.054795
0.033268
0.02544
0.007828
0.039139
1
5,041
G
C
A
G
T
T
C
T
C
C
A
T
G
C
T
G
G
C
C
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G
0.005871
0.013699
0.035225
0.009785
0.02544
0.043053
0.02544
0.019569
0.035225
0.056751
0.046967
0.003914
0.013699
0.039139
0.019569
0.052838
0.060665
0.066536
0.060665
0.017613
0.013699
0.017613
0.021526
0.041096
0.035225
0.019569
0.04501
0.060665
0.027397
0.027397
0.003914
0.035225
1
5,042
G
A
C
G
T
A
G
A
G
C
G
T
G
A
G
G
A
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0.005871
0.013699
0.033268
0.009785
0.02544
0.041096
0.02544
0.019569
0.033268
0.060665
0.04501
0.003914
0.013699
0.043053
0.019569
0.052838
0.058708
0.066536
0.052838
0.021526
0.013699
0.017613
0.021526
0.04501
0.035225
0.017613
0.046967
0.062622
0.029354
0.027397
0.001957
0.035225
1
5,043
T
G
A
C
G
T
A
G
A
G
C
G
T
G
A
G
G
A
A
G
T
T
G
A
T
G
G
G
G
A
A
G
C
C
C
A
G
C
A
C
G
A
T
C
A
G
C
A
G
A
A
A
C
A
T
G
T
A
G
G
C
G
G
C
C
A
0.005871
0.013699
0.033268
0.009785
0.02544
0.039139
0.02544
0.019569
0.033268
0.060665
0.04501
0.003914
0.013699
0.043053
0.019569
0.052838
0.058708
0.066536
0.052838
0.021526
0.013699
0.017613
0.021526
0.04501
0.035225
0.017613
0.046967
0.062622
0.031311
0.027397
0.001957
0.035225
1
5,044
C
T
A
C
A
T
G
T
T
T
C
T
G
C
T
G
A
T
C
G
T
G
C
T
G
G
G
C
T
T
C
C
C
C
A
T
C
A
A
C
T
T
C
C
T
C
A
C
G
C
T
C
T
A
C
G
T
C
A
C
C
G
T
C
C
G
0.005871
0.011742
0.033268
0.009785
0.02544
0.041096
0.02544
0.019569
0.031311
0.060665
0.046967
0.003914
0.013699
0.043053
0.019569
0.052838
0.056751
0.066536
0.056751
0.021526
0.013699
0.017613
0.021526
0.046967
0.033268
0.017613
0.046967
0.062622
0.031311
0.027397
0.001957
0.033268
1
5,045
T
T
T
C
T
G
C
T
G
A
T
C
G
T
G
C
T
G
G
G
C
T
T
C
C
C
C
A
T
C
A
A
C
T
T
C
C
T
C
A
C
G
C
T
C
T
A
C
G
T
C
A
C
C
G
T
C
C
A
G
C
A
C
A
A
G
0.005871
0.011742
0.033268
0.009785
0.02544
0.039139
0.02544
0.017613
0.033268
0.060665
0.046967
0.003914
0.013699
0.043053
0.019569
0.052838
0.056751
0.066536
0.056751
0.021526
0.013699
0.017613
0.021526
0.046967
0.033268
0.017613
0.046967
0.062622
0.033268
0.027397
0.001957
0.033268
1
5,046
C
G
T
G
C
T
G
G
G
C
T
T
C
C
C
C
A
T
C
A
A
C
T
T
C
C
T
C
A
C
G
C
T
C
T
A
C
G
T
C
A
C
C
G
T
C
C
A
G
C
A
C
A
A
G
A
A
G
C
T
G
C
G
C
A
A
0.005871
0.011742
0.035225
0.009785
0.02544
0.039139
0.02544
0.019569
0.033268
0.058708
0.046967
0.003914
0.011742
0.041096
0.019569
0.052838
0.052838
0.062622
0.060665
0.02544
0.013699
0.017613
0.021526
0.048924
0.033268
0.017613
0.046967
0.064579
0.033268
0.027397
0.001957
0.031311
1