row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
f_6_ref__26
string
f_7_ref__25
string
f_8_ref__24
string
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string
f_10_ref__22
string
f_11_ref__21
string
f_12_ref__20
string
f_13_ref__19
string
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string
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string
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string
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string
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string
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string
f_20_ref__12
string
f_21_ref__11
string
f_22_ref__10
string
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string
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string
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string
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string
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string
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string
f_29_ref__3
string
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string
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string
f_32_ref_0
string
f_33_ref__1
string
f_34_ref__2
string
f_35_ref__3
string
f_36_ref__4
string
f_37_ref__5
string
f_38_ref__6
string
f_39_ref__7
string
f_40_ref__8
string
f_41_ref__9
string
f_42_ref__10
string
f_43_ref__11
string
f_44_ref__12
string
f_45_ref__13
string
f_46_ref__14
string
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string
f_48_ref__16
string
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string
f_50_ref__18
string
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string
f_52_ref__20
string
f_53_ref__21
string
f_54_ref__22
string
f_55_ref__23
string
f_56_ref__24
string
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string
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string
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string
f_60_ref__28
string
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string
f_62_ref__30
string
f_63_ref__31
string
f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
5,047
G
G
T
C
A
G
C
C
A
C
G
G
C
T
A
G
G
T
T
G
A
G
C
A
G
G
A
T
G
T
A
G
T
T
G
A
G
A
G
G
C
G
T
G
C
G
C
A
G
C
T
T
C
T
T
G
T
G
C
T
G
G
A
C
G
C
0.005871
0.011742
0.035225
0.007828
0.029354
0.043053
0.02544
0.017613
0.037182
0.050881
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0.019569
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0.064579
0.058708
0.027397
0.011742
0.017613
0.021526
0.048924
0.033268
0.019569
0.043053
0.064579
0.037182
0.027397
0.001957
0.027397
1
5,048
C
T
A
G
G
A
C
C
A
T
G
A
A
G
A
G
G
T
C
A
G
C
C
A
C
G
G
C
T
A
G
G
T
T
G
A
G
C
A
G
G
A
T
G
T
A
G
T
T
G
A
G
A
G
G
C
G
T
G
C
G
C
A
G
C
A
0.007828
0.013699
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0.009785
0.031311
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0.048924
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0.041096
0.062622
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0.027397
0.003914
0.029354
1
5,049
G
C
A
G
A
G
A
G
G
T
G
T
A
G
A
G
G
G
T
G
C
T
G
G
T
G
A
A
G
C
C
A
C
C
T
A
G
G
A
C
C
A
T
G
A
A
G
A
G
G
T
C
A
G
C
C
A
C
G
G
C
T
A
G
G
T
0.009785
0.017613
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0.011742
0.031311
0.041096
0.023483
0.019569
0.037182
0.04501
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0.041096
0.02544
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0.011742
0.017613
0.021526
0.048924
0.035225
0.021526
0.039139
0.054795
0.037182
0.027397
0.003914
0.033268
1
5,050
C
A
T
G
C
A
G
A
G
A
G
G
T
G
T
A
G
A
G
G
G
T
G
C
T
G
G
T
G
A
A
G
C
C
A
C
C
T
A
G
G
A
C
C
A
T
G
A
A
G
A
G
G
T
C
A
G
C
C
A
C
G
G
C
T
T
0.009785
0.017613
0.035225
0.011742
0.029354
0.043053
0.023483
0.019569
0.035225
0.04501
0.050881
0.013699
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0.043053
0.02544
0.046967
0.04501
0.058708
0.054795
0.02544
0.011742
0.017613
0.021526
0.048924
0.035225
0.021526
0.039139
0.054795
0.037182
0.027397
0.003914
0.033268
1
5,051
A
A
T
T
G
C
A
T
C
C
T
G
T
G
G
G
C
C
C
G
A
A
G
A
C
G
A
A
G
T
A
T
C
C
A
T
G
C
A
G
A
G
A
G
G
T
G
T
A
G
A
G
G
G
T
G
C
T
G
G
T
G
A
A
G
A
0.011742
0.017613
0.029354
0.009785
0.033268
0.043053
0.019569
0.017613
0.031311
0.052838
0.046967
0.015656
0.015656
0.041096
0.02544
0.048924
0.052838
0.058708
0.054795
0.029354
0.011742
0.017613
0.019569
0.046967
0.029354
0.021526
0.043053
0.056751
0.035225
0.02544
0.001957
0.035225
1
5,052
A
A
A
G
A
A
G
C
C
C
T
C
C
A
A
A
T
T
G
C
A
T
C
C
T
G
T
G
G
G
C
C
C
G
A
A
G
A
C
G
A
A
G
T
A
T
C
C
A
T
G
C
A
G
A
G
A
G
G
T
G
T
A
G
A
G
0.011742
0.019569
0.031311
0.009785
0.033268
0.039139
0.017613
0.021526
0.031311
0.052838
0.048924
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0.015656
0.041096
0.02544
0.048924
0.056751
0.056751
0.052838
0.027397
0.009785
0.015656
0.019569
0.046967
0.031311
0.019569
0.04501
0.058708
0.035225
0.021526
0.001957
0.037182
1
5,053
T
G
C
A
T
G
G
A
T
A
C
T
T
C
G
T
C
T
T
C
G
G
G
C
C
C
A
C
A
G
G
A
T
G
C
A
A
T
T
T
G
G
A
G
G
G
C
T
T
C
T
T
T
G
C
C
A
C
C
C
T
G
G
G
C
C
0.013699
0.019569
0.031311
0.011742
0.033268
0.039139
0.015656
0.021526
0.033268
0.050881
0.046967
0.017613
0.019569
0.041096
0.029354
0.048924
0.054795
0.058708
0.048924
0.027397
0.007828
0.013699
0.019569
0.046967
0.029354
0.019569
0.043053
0.056751
0.035225
0.021526
0.003914
0.039139
1
5,054
C
G
C
C
C
A
G
G
G
T
G
G
C
A
A
A
G
A
A
G
C
C
C
T
C
C
A
A
A
T
T
G
C
A
T
C
C
T
G
T
G
G
G
C
C
C
G
A
A
G
A
C
G
A
A
G
T
A
T
C
C
A
T
G
C
T
0.013699
0.019569
0.031311
0.011742
0.033268
0.039139
0.015656
0.021526
0.033268
0.050881
0.046967
0.017613
0.019569
0.041096
0.029354
0.048924
0.054795
0.058708
0.048924
0.027397
0.005871
0.013699
0.019569
0.046967
0.029354
0.019569
0.043053
0.056751
0.037182
0.021526
0.003914
0.039139
1
5,055
G
C
T
C
A
T
A
C
C
G
C
C
C
A
G
G
G
T
G
G
C
A
A
A
G
A
A
G
C
C
C
T
C
C
A
A
A
T
T
G
C
A
T
C
C
T
G
T
G
G
G
C
C
C
G
A
A
G
A
C
G
A
A
G
T
T
0.013699
0.019569
0.031311
0.013699
0.033268
0.037182
0.015656
0.019569
0.033268
0.052838
0.046967
0.021526
0.019569
0.043053
0.031311
0.046967
0.054795
0.056751
0.046967
0.027397
0.005871
0.013699
0.019569
0.046967
0.029354
0.019569
0.04501
0.056751
0.037182
0.017613
0.003914
0.039139
1
5,056
C
C
C
G
G
C
T
C
A
T
A
C
C
G
C
C
C
A
G
G
G
T
G
G
C
A
A
A
G
A
A
G
C
C
C
T
C
C
A
A
A
T
T
G
C
A
T
C
C
T
G
T
G
G
G
C
C
C
G
A
A
G
A
C
G
T
0.013699
0.019569
0.031311
0.013699
0.031311
0.037182
0.015656
0.017613
0.033268
0.054795
0.046967
0.021526
0.019569
0.043053
0.031311
0.046967
0.052838
0.056751
0.046967
0.027397
0.005871
0.017613
0.019569
0.046967
0.029354
0.019569
0.046967
0.056751
0.037182
0.015656
0.003914
0.039139
1
5,057
C
C
C
G
G
C
T
C
A
T
A
C
C
G
C
C
C
A
G
G
G
T
G
G
C
A
A
A
G
A
A
G
C
C
C
T
C
C
A
A
A
T
T
G
C
A
T
C
C
T
G
T
G
G
G
C
C
C
G
A
A
G
A
C
G
A
0.013699
0.019569
0.031311
0.013699
0.031311
0.037182
0.015656
0.017613
0.033268
0.054795
0.046967
0.021526
0.019569
0.043053
0.031311
0.046967
0.052838
0.056751
0.046967
0.027397
0.005871
0.017613
0.019569
0.046967
0.029354
0.019569
0.046967
0.056751
0.037182
0.015656
0.003914
0.039139
1
5,058
G
C
C
T
G
C
T
G
A
C
T
G
C
C
T
T
G
C
A
G
G
T
G
A
A
A
T
T
G
C
C
C
T
G
T
G
G
T
C
C
T
T
G
G
T
G
G
T
C
C
T
G
G
C
C
A
T
C
G
A
G
C
G
G
T
G
0.013699
0.013699
0.037182
0.015656
0.015656
0.046967
0.007828
0.02544
0.029354
0.04501
0.07045
0.001957
0.005871
0.023483
0.02544
0.041096
0.058708
0.064579
0.080235
0.017613
0.007828
0.02544
0.017613
0.054795
0.031311
0.027397
0.043053
0.046967
0.056751
0.013699
0.009785
0.02544
1
5,059
T
G
A
C
T
G
C
C
T
T
G
C
A
G
G
T
G
A
A
A
T
T
G
C
C
C
T
G
T
G
G
T
C
C
T
T
G
G
T
G
G
T
C
C
T
G
G
C
C
A
T
C
G
A
G
C
G
G
T
A
C
G
T
G
G
T
0.013699
0.013699
0.039139
0.015656
0.017613
0.046967
0.007828
0.02544
0.027397
0.043053
0.07045
0.003914
0.005871
0.02544
0.027397
0.041096
0.056751
0.062622
0.078278
0.017613
0.007828
0.02544
0.017613
0.052838
0.031311
0.027397
0.043053
0.046967
0.056751
0.015656
0.009785
0.02544
1
5,060
C
C
C
T
G
T
G
G
T
C
C
T
T
G
G
T
G
G
T
C
C
T
G
G
C
C
A
T
C
G
A
G
C
G
G
T
A
C
G
T
G
G
T
G
G
T
G
T
G
T
A
A
G
C
C
C
A
T
G
A
G
C
A
A
C
G
0.013699
0.011742
0.035225
0.015656
0.019569
0.046967
0.007828
0.02544
0.029354
0.039139
0.072407
0.001957
0.005871
0.02544
0.027397
0.043053
0.058708
0.066536
0.076321
0.017613
0.007828
0.021526
0.015656
0.056751
0.029354
0.029354
0.043053
0.052838
0.056751
0.015656
0.005871
0.02544
1
5,061
C
C
C
T
G
T
G
G
T
C
C
T
T
G
G
T
G
G
T
C
C
T
G
G
C
C
A
T
C
G
A
G
C
G
G
T
A
C
G
T
G
G
T
G
G
T
G
T
G
T
A
A
G
C
C
C
A
T
G
A
G
C
A
A
C
T
0.013699
0.011742
0.035225
0.015656
0.019569
0.046967
0.007828
0.02544
0.029354
0.039139
0.072407
0.001957
0.005871
0.02544
0.027397
0.043053
0.058708
0.066536
0.076321
0.017613
0.007828
0.021526
0.015656
0.056751
0.029354
0.029354
0.043053
0.052838
0.056751
0.015656
0.005871
0.02544
1
5,062
A
G
T
T
G
C
T
C
A
T
G
G
G
C
T
T
A
C
A
C
A
C
C
A
C
C
A
C
G
T
A
C
C
G
C
T
C
G
A
T
G
G
C
C
A
G
G
A
C
C
A
C
C
A
A
G
G
A
C
C
A
C
A
G
G
G
0.013699
0.011742
0.035225
0.013699
0.019569
0.046967
0.007828
0.02544
0.029354
0.039139
0.072407
0.001957
0.005871
0.02544
0.027397
0.043053
0.058708
0.066536
0.076321
0.017613
0.007828
0.021526
0.015656
0.056751
0.029354
0.029354
0.043053
0.052838
0.056751
0.015656
0.005871
0.027397
1
5,063
A
G
T
T
G
C
T
C
A
T
G
G
G
C
T
T
A
C
A
C
A
C
C
A
C
C
A
C
G
T
A
C
C
G
C
T
C
G
A
T
G
G
C
C
A
G
G
A
C
C
A
C
C
A
A
G
G
A
C
C
A
C
A
G
G
A
0.013699
0.011742
0.035225
0.013699
0.019569
0.046967
0.007828
0.02544
0.029354
0.039139
0.072407
0.001957
0.005871
0.02544
0.027397
0.043053
0.058708
0.066536
0.076321
0.017613
0.007828
0.021526
0.015656
0.056751
0.029354
0.029354
0.043053
0.052838
0.056751
0.015656
0.005871
0.027397
1
5,064
C
A
T
C
A
T
G
G
G
C
G
T
T
G
C
C
T
T
C
A
C
C
T
G
G
G
T
C
A
T
G
G
C
G
C
T
G
G
C
C
T
G
C
G
C
C
G
C
A
C
C
C
C
C
A
C
T
C
G
C
C
G
G
C
T
A
0.013699
0.017613
0.033268
0.011742
0.029354
0.048924
0.005871
0.027397
0.033268
0.033268
0.068493
0.001957
0.007828
0.033268
0.029354
0.039139
0.060665
0.062622
0.07045
0.017613
0.007828
0.019569
0.023483
0.04501
0.027397
0.033268
0.041096
0.054795
0.043053
0.021526
0.007828
0.029354
1
5,065
G
T
T
G
C
C
T
T
C
A
C
C
T
G
G
G
T
C
A
T
G
G
C
G
C
T
G
G
C
C
T
G
C
G
C
C
G
C
A
C
C
C
C
C
A
C
T
C
G
C
C
G
G
C
T
G
G
T
C
C
A
G
G
T
A
G
0.013699
0.017613
0.033268
0.013699
0.031311
0.048924
0.005871
0.027397
0.035225
0.033268
0.062622
0.001957
0.009785
0.035225
0.029354
0.039139
0.060665
0.062622
0.07045
0.017613
0.007828
0.019569
0.023483
0.043053
0.027397
0.035225
0.041096
0.050881
0.043053
0.021526
0.007828
0.029354
1
5,066
C
C
A
T
T
A
C
C
T
G
G
A
C
C
A
G
C
C
G
G
C
G
A
G
T
G
G
G
G
G
T
G
C
G
G
C
G
C
A
G
G
C
C
A
G
C
G
C
C
A
T
G
A
C
C
C
A
G
G
T
G
A
A
G
G
G
0.011742
0.017613
0.033268
0.013699
0.031311
0.048924
0.005871
0.027397
0.035225
0.033268
0.062622
0.001957
0.011742
0.035225
0.027397
0.039139
0.060665
0.064579
0.072407
0.017613
0.007828
0.019569
0.023483
0.041096
0.027397
0.035225
0.041096
0.050881
0.04501
0.021526
0.007828
0.027397
1
5,067
C
C
T
G
G
G
T
C
A
T
G
G
C
G
C
T
G
G
C
C
T
G
C
G
C
C
G
C
A
C
C
C
C
C
A
C
T
C
G
C
C
G
G
C
T
G
G
T
C
C
A
G
G
T
A
A
T
G
G
C
A
C
T
G
A
T
0.011742
0.019569
0.035225
0.011742
0.031311
0.050881
0.005871
0.027397
0.035225
0.033268
0.062622
0.001957
0.009785
0.035225
0.029354
0.039139
0.060665
0.064579
0.072407
0.017613
0.007828
0.019569
0.023483
0.039139
0.027397
0.035225
0.041096
0.050881
0.043053
0.021526
0.007828
0.027397
1
5,068
C
T
G
G
G
T
C
A
T
G
G
C
G
C
T
G
G
C
C
T
G
C
G
C
C
G
C
A
C
C
C
C
C
A
C
T
C
G
C
C
G
G
C
T
G
G
T
C
C
A
G
G
T
A
A
T
G
G
C
A
C
T
G
A
G
G
0.011742
0.019569
0.035225
0.011742
0.031311
0.050881
0.005871
0.027397
0.033268
0.033268
0.062622
0.001957
0.009785
0.035225
0.029354
0.039139
0.060665
0.064579
0.072407
0.017613
0.007828
0.019569
0.023483
0.039139
0.029354
0.035225
0.041096
0.050881
0.043053
0.021526
0.007828
0.027397
1
5,069
C
C
C
T
T
C
T
G
C
T
C
A
G
T
G
C
C
A
T
T
A
C
C
T
G
G
A
C
C
A
G
C
C
G
G
C
G
A
G
T
G
G
G
G
G
T
G
C
G
G
C
G
C
A
G
G
C
C
A
G
C
G
C
C
A
T
0.011742
0.019569
0.037182
0.011742
0.031311
0.052838
0.005871
0.02544
0.033268
0.033268
0.064579
0.001957
0.009785
0.035225
0.031311
0.039139
0.060665
0.064579
0.07045
0.017613
0.007828
0.019569
0.023483
0.035225
0.029354
0.035225
0.041096
0.052838
0.039139
0.021526
0.007828
0.029354
1
5,070
G
G
T
C
T
C
C
C
T
A
C
C
T
G
C
C
T
G
T
C
C
T
C
A
G
G
T
A
C
A
T
C
C
C
C
G
A
G
G
G
C
C
T
G
C
A
G
T
G
C
T
C
G
T
G
T
G
G
A
A
T
C
G
A
C
T
0.019569
0.013699
0.02544
0.011742
0.031311
0.037182
0.021526
0.013699
0.029354
0.041096
0.052838
0.005871
0.035225
0.052838
0.019569
0.039139
0.060665
0.058708
0.066536
0.021526
0.017613
0.013699
0.009785
0.041096
0.02544
0.033268
0.043053
0.046967
0.050881
0.017613
0.005871
0.037182
1
5,071
G
T
A
G
T
A
G
T
C
G
A
T
T
C
C
A
C
A
C
G
A
G
C
A
C
T
G
C
A
G
G
C
C
C
T
C
G
G
G
G
A
T
G
T
A
C
C
T
G
A
G
G
A
C
A
G
G
C
A
G
G
T
A
G
G
T
0.019569
0.013699
0.02544
0.011742
0.031311
0.039139
0.021526
0.013699
0.029354
0.041096
0.050881
0.005871
0.035225
0.048924
0.019569
0.039139
0.058708
0.058708
0.068493
0.02544
0.017613
0.013699
0.009785
0.041096
0.02544
0.035225
0.039139
0.046967
0.052838
0.017613
0.005871
0.037182
1
5,072
T
G
T
A
G
T
A
G
T
C
G
A
T
T
C
C
A
C
A
C
G
A
G
C
A
C
T
G
C
A
G
G
C
C
C
T
C
G
G
G
G
A
T
G
T
A
C
C
T
G
A
G
G
A
C
A
G
G
C
A
G
G
T
A
G
T
0.019569
0.013699
0.02544
0.011742
0.031311
0.039139
0.021526
0.013699
0.029354
0.041096
0.050881
0.005871
0.035225
0.048924
0.019569
0.039139
0.058708
0.058708
0.068493
0.02544
0.017613
0.013699
0.009785
0.041096
0.02544
0.035225
0.039139
0.046967
0.052838
0.017613
0.005871
0.037182
1
5,073
T
G
T
A
G
T
A
G
T
C
G
A
T
T
C
C
A
C
A
C
G
A
G
C
A
C
T
G
C
A
G
G
C
C
C
T
C
G
G
G
G
A
T
G
T
A
C
C
T
G
A
G
G
A
C
A
G
G
C
A
G
G
T
A
G
A
0.019569
0.013699
0.02544
0.011742
0.031311
0.039139
0.021526
0.013699
0.029354
0.041096
0.050881
0.005871
0.035225
0.048924
0.019569
0.039139
0.058708
0.058708
0.068493
0.02544
0.017613
0.013699
0.009785
0.041096
0.02544
0.035225
0.039139
0.046967
0.052838
0.017613
0.005871
0.037182
1
5,074
C
C
T
C
A
G
G
T
A
C
A
T
C
C
C
C
G
A
G
G
G
C
C
T
G
C
A
G
T
G
C
T
C
G
T
G
T
G
G
A
A
T
C
G
A
C
T
A
C
T
A
C
A
C
G
C
T
C
A
A
G
C
C
G
G
G
0.019569
0.013699
0.02544
0.011742
0.033268
0.037182
0.023483
0.013699
0.027397
0.039139
0.052838
0.005871
0.035225
0.048924
0.019569
0.039139
0.060665
0.056751
0.066536
0.027397
0.017613
0.013699
0.009785
0.037182
0.02544
0.037182
0.043053
0.04501
0.052838
0.017613
0.005871
0.037182
1
5,075
G
A
C
C
T
C
C
G
G
C
T
T
G
A
G
C
G
T
G
T
A
G
T
A
G
T
C
G
A
T
T
C
C
A
C
A
C
G
A
G
C
A
C
T
G
C
A
G
G
C
C
C
T
C
G
G
G
G
A
T
G
T
A
C
C
T
0.019569
0.013699
0.02544
0.011742
0.031311
0.035225
0.023483
0.013699
0.027397
0.041096
0.052838
0.005871
0.035225
0.048924
0.019569
0.037182
0.060665
0.054795
0.066536
0.029354
0.017613
0.015656
0.009785
0.037182
0.02544
0.035225
0.043053
0.048924
0.052838
0.017613
0.005871
0.037182
1
5,076
G
T
T
G
T
T
G
A
C
C
T
C
C
G
G
C
T
T
G
A
G
C
G
T
G
T
A
G
T
A
G
T
C
G
A
T
T
C
C
A
C
A
C
G
A
G
C
A
C
T
G
C
A
G
G
C
C
C
T
C
G
G
G
G
A
T
0.019569
0.013699
0.02544
0.011742
0.031311
0.035225
0.023483
0.013699
0.02544
0.041096
0.052838
0.005871
0.033268
0.046967
0.019569
0.037182
0.062622
0.054795
0.068493
0.029354
0.017613
0.015656
0.009785
0.037182
0.02544
0.035225
0.04501
0.050881
0.052838
0.017613
0.005871
0.035225
1
5,077
G
T
T
G
T
T
G
A
C
C
T
C
C
G
G
C
T
T
G
A
G
C
G
T
G
T
A
G
T
A
G
T
C
G
A
T
T
C
C
A
C
A
C
G
A
G
C
A
C
T
G
C
A
G
G
C
C
C
T
C
G
G
G
G
A
A
0.019569
0.013699
0.02544
0.011742
0.031311
0.035225
0.023483
0.013699
0.02544
0.041096
0.052838
0.005871
0.033268
0.046967
0.019569
0.037182
0.062622
0.054795
0.068493
0.029354
0.017613
0.015656
0.009785
0.037182
0.02544
0.035225
0.04501
0.050881
0.052838
0.017613
0.005871
0.035225
1
5,078
C
G
T
T
G
T
T
G
A
C
C
T
C
C
G
G
C
T
T
G
A
G
C
G
T
G
T
A
G
T
A
G
T
C
G
A
T
T
C
C
A
C
A
C
G
A
G
C
A
C
T
G
C
A
G
G
C
C
C
T
C
G
G
G
G
C
0.019569
0.013699
0.02544
0.011742
0.031311
0.033268
0.023483
0.013699
0.02544
0.043053
0.052838
0.005871
0.033268
0.046967
0.019569
0.037182
0.062622
0.054795
0.068493
0.029354
0.017613
0.015656
0.009785
0.037182
0.02544
0.035225
0.04501
0.050881
0.052838
0.017613
0.005871
0.035225
1
5,079
C
C
C
G
A
G
G
G
C
C
T
G
C
A
G
T
G
C
T
C
G
T
G
T
G
G
A
A
T
C
G
A
C
T
A
C
T
A
C
A
C
G
C
T
C
A
A
G
C
C
G
G
A
G
G
T
C
A
A
C
A
A
C
G
A
G
0.019569
0.013699
0.02544
0.011742
0.031311
0.033268
0.023483
0.013699
0.02544
0.043053
0.052838
0.005871
0.033268
0.046967
0.019569
0.037182
0.062622
0.054795
0.068493
0.029354
0.017613
0.015656
0.009785
0.037182
0.02544
0.035225
0.046967
0.050881
0.052838
0.015656
0.005871
0.035225
1
5,080
G
G
A
G
G
T
C
A
A
C
A
A
C
G
A
G
T
C
T
T
T
T
G
T
C
A
T
C
T
A
C
A
T
G
T
T
C
G
T
G
G
T
C
C
A
C
T
T
C
A
C
C
A
T
C
C
C
C
A
T
G
A
T
T
A
G
0.017613
0.009785
0.02544
0.007828
0.029354
0.035225
0.021526
0.013699
0.029354
0.043053
0.058708
0.005871
0.029354
0.046967
0.013699
0.037182
0.066536
0.054795
0.07045
0.031311
0.015656
0.013699
0.009785
0.043053
0.02544
0.037182
0.04501
0.052838
0.054795
0.015656
0.003914
0.035225
1
5,081
A
G
A
A
A
A
A
G
A
T
G
A
T
A
A
T
C
A
T
G
G
G
G
A
T
G
G
T
G
A
A
G
T
G
G
A
C
C
A
C
G
A
A
C
A
T
G
T
A
G
A
T
G
A
C
A
A
A
A
G
A
C
T
C
G
C
0.017613
0.009785
0.02544
0.007828
0.029354
0.037182
0.021526
0.013699
0.027397
0.043053
0.058708
0.005871
0.029354
0.050881
0.013699
0.037182
0.064579
0.054795
0.066536
0.031311
0.015656
0.013699
0.009785
0.043053
0.02544
0.039139
0.043053
0.052838
0.052838
0.015656
0.003914
0.039139
1
5,082
C
A
T
C
T
A
C
A
T
G
T
T
C
G
T
G
G
T
C
C
A
C
T
T
C
A
C
C
A
T
C
C
C
C
A
T
G
A
T
T
A
T
C
A
T
C
T
T
T
T
T
C
T
G
C
T
A
T
G
G
G
C
A
G
C
T
0.019569
0.009785
0.027397
0.005871
0.029354
0.039139
0.021526
0.013699
0.027397
0.04501
0.058708
0.005871
0.02544
0.048924
0.013699
0.037182
0.064579
0.050881
0.066536
0.031311
0.017613
0.015656
0.009785
0.043053
0.02544
0.041096
0.043053
0.052838
0.048924
0.015656
0.003914
0.041096
1
5,083
T
C
A
T
G
G
T
C
A
T
C
G
C
T
T
T
C
C
T
G
A
T
C
T
G
C
T
G
G
G
T
G
C
C
C
T
A
C
G
C
C
A
G
C
G
T
G
G
C
A
T
T
C
T
A
C
A
T
C
T
T
C
A
C
C
A
0.007828
0.009785
0.029354
0.001957
0.017613
0.041096
0.015656
0.013699
0.033268
0.048924
0.054795
0.007828
0.027397
0.048924
0.017613
0.031311
0.074364
0.064579
0.076321
0.029354
0.005871
0.027397
0.013699
0.033268
0.023483
0.031311
0.052838
0.066536
0.039139
0.015656
0.001957
0.037182
1
5,084
C
A
T
G
G
T
C
A
T
C
G
C
T
T
T
C
C
T
G
A
T
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C
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G
G
C
A
T
T
C
T
A
C
A
T
C
T
T
C
A
C
C
C
T
0.005871
0.009785
0.029354
0.001957
0.017613
0.041096
0.015656
0.013699
0.033268
0.048924
0.054795
0.007828
0.027397
0.048924
0.017613
0.031311
0.074364
0.064579
0.078278
0.029354
0.005871
0.027397
0.013699
0.033268
0.023483
0.031311
0.052838
0.066536
0.039139
0.015656
0.001957
0.037182
1
5,085
C
A
A
C
T
T
C
G
G
T
C
C
C
A
T
C
T
T
C
A
T
G
A
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C
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G
A
G
C
G
C
C
G
C
C
A
T
C
T
A
C
A
A
C
C
A
0.005871
0.011742
0.02544
0.009785
0.021526
0.037182
0.007828
0.021526
0.035225
0.04501
0.050881
0.005871
0.031311
0.050881
0.017613
0.035225
0.084149
0.07045
0.074364
0.017613
0.003914
0.02544
0.011742
0.031311
0.027397
0.031311
0.056751
0.056751
0.043053
0.011742
0.001957
0.039139
1
5,086
A
T
A
G
A
T
G
A
C
A
G
G
G
T
T
G
T
A
G
A
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A
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T
G
G
G
A
T
G
G
T
C
A
T
G
A
A
G
A
T
G
G
C
0.005871
0.013699
0.02544
0.009785
0.021526
0.039139
0.007828
0.021526
0.035225
0.043053
0.052838
0.005871
0.031311
0.050881
0.017613
0.035225
0.082192
0.068493
0.072407
0.017613
0.003914
0.02544
0.011742
0.031311
0.029354
0.029354
0.056751
0.058708
0.043053
0.011742
0.001957
0.039139
1
5,087
A
T
A
T
A
G
A
T
G
A
C
A
G
G
G
T
T
G
T
A
G
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C
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A
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G
C
T
G
G
G
A
T
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G
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C
A
T
G
A
A
G
A
T
G
0.005871
0.013699
0.02544
0.009785
0.021526
0.039139
0.007828
0.021526
0.035225
0.041096
0.054795
0.005871
0.031311
0.050881
0.017613
0.035225
0.084149
0.068493
0.072407
0.017613
0.003914
0.02544
0.011742
0.031311
0.029354
0.029354
0.054795
0.058708
0.043053
0.011742
0.001957
0.039139
1
5,088
G
A
T
A
T
A
G
A
T
G
A
C
A
G
G
G
T
T
G
T
A
G
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C
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C
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C
A
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C
G
C
T
G
G
G
A
T
G
G
T
C
A
T
G
A
A
G
A
G
0.005871
0.013699
0.02544
0.009785
0.021526
0.039139
0.007828
0.021526
0.035225
0.041096
0.054795
0.005871
0.031311
0.048924
0.017613
0.035225
0.084149
0.068493
0.072407
0.017613
0.003914
0.02544
0.011742
0.031311
0.029354
0.029354
0.056751
0.058708
0.043053
0.011742
0.001957
0.039139
1
5,089
T
T
C
A
T
G
A
C
C
A
T
C
C
C
A
G
C
G
T
T
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C
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C
T
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T
C
A
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T
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A
T
C
A
T
G
0.005871
0.013699
0.02544
0.009785
0.021526
0.039139
0.007828
0.021526
0.035225
0.041096
0.054795
0.005871
0.031311
0.048924
0.017613
0.035225
0.084149
0.068493
0.072407
0.017613
0.003914
0.02544
0.011742
0.031311
0.029354
0.029354
0.056751
0.058708
0.043053
0.011742
0.001957
0.039139
1
5,090
C
A
G
A
G
T
C
C
T
A
G
G
C
A
G
G
T
C
T
T
A
G
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C
C
G
G
G
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C
C
A
C
C
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G
G
C
T
C
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C
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C
C
G
T
C
T
T
G
G
A
C
A
C
G
G
T
A
G
C
A
G
G
0.033268
0.017613
0.033268
0.017613
0.019569
0.029354
0.021526
0.027397
0.029354
0.039139
0.064579
0.007828
0.019569
0.021526
0.017613
0.04501
0.062622
0.060665
0.052838
0.019569
0.013699
0.015656
0.023483
0.041096
0.033268
0.029354
0.037182
0.062622
0.050881
0.005871
0.017613
0.029354
1
5,091
C
A
G
A
G
T
C
C
T
A
G
G
C
A
G
G
T
C
T
T
A
G
G
C
C
G
G
G
G
C
C
A
C
C
T
G
G
C
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C
G
T
C
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C
C
G
T
C
T
T
G
G
A
C
A
C
G
G
T
A
G
C
A
G
A
0.033268
0.017613
0.033268
0.017613
0.019569
0.029354
0.021526
0.027397
0.029354
0.039139
0.064579
0.007828
0.019569
0.021526
0.017613
0.04501
0.062622
0.060665
0.052838
0.019569
0.013699
0.015656
0.023483
0.041096
0.033268
0.029354
0.037182
0.062622
0.050881
0.005871
0.017613
0.029354
1
5,092
C
C
G
T
G
T
C
C
A
A
G
A
C
G
G
A
G
A
C
G
A
G
C
C
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G
G
T
G
G
C
C
C
C
G
G
C
C
T
A
A
G
A
C
C
T
G
C
C
T
A
G
G
A
C
T
C
T
G
T
G
G
C
C
G
A
0.033268
0.017613
0.033268
0.017613
0.021526
0.029354
0.021526
0.027397
0.029354
0.037182
0.062622
0.007828
0.021526
0.023483
0.017613
0.046967
0.062622
0.060665
0.054795
0.019569
0.013699
0.015656
0.019569
0.041096
0.033268
0.029354
0.035225
0.060665
0.052838
0.005871
0.017613
0.029354
1
5,093
C
C
G
T
G
T
C
C
A
A
G
A
C
G
G
A
G
A
C
G
A
G
C
C
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G
T
G
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C
C
C
C
G
G
C
C
T
A
A
G
A
C
C
T
G
C
C
T
A
G
G
A
C
T
C
T
G
T
G
G
C
C
G
G
0.033268
0.017613
0.033268
0.017613
0.021526
0.029354
0.021526
0.027397
0.029354
0.037182
0.062622
0.007828
0.021526
0.023483
0.017613
0.046967
0.062622
0.060665
0.054795
0.019569
0.013699
0.015656
0.019569
0.041096
0.033268
0.029354
0.035225
0.060665
0.052838
0.005871
0.017613
0.029354
1
5,094
C
C
G
T
G
T
C
C
A
A
G
A
C
G
G
A
G
A
C
G
A
G
C
C
A
G
G
T
G
G
C
C
C
C
G
G
C
C
T
A
A
G
A
C
C
T
G
C
C
T
A
G
G
A
C
T
C
T
G
T
G
G
C
C
G
T
0.033268
0.017613
0.033268
0.017613
0.021526
0.029354
0.021526
0.027397
0.029354
0.037182
0.062622
0.007828
0.021526
0.023483
0.017613
0.046967
0.062622
0.060665
0.054795
0.019569
0.013699
0.015656
0.019569
0.041096
0.033268
0.029354
0.035225
0.060665
0.052838
0.005871
0.017613
0.029354
1
5,095
C
G
T
G
T
C
C
A
A
G
A
C
G
G
A
G
A
C
G
A
G
C
C
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G
G
T
G
G
C
C
C
C
G
G
C
C
T
A
A
G
A
C
C
T
G
C
C
T
A
G
G
A
C
T
C
T
G
T
G
G
C
C
G
A
A
0.033268
0.017613
0.033268
0.017613
0.023483
0.029354
0.021526
0.027397
0.029354
0.037182
0.062622
0.007828
0.021526
0.023483
0.017613
0.046967
0.060665
0.060665
0.054795
0.019569
0.013699
0.015656
0.019569
0.041096
0.033268
0.029354
0.035225
0.060665
0.052838
0.005871
0.017613
0.029354
1
5,096
C
G
T
G
T
C
C
A
A
G
A
C
G
G
A
G
A
C
G
A
G
C
C
A
G
G
T
G
G
C
C
C
C
G
G
C
C
T
A
A
G
A
C
C
T
G
C
C
T
A
G
G
A
C
T
C
T
G
T
G
G
C
C
G
A
G
0.033268
0.017613
0.033268
0.017613
0.023483
0.029354
0.021526
0.027397
0.029354
0.037182
0.062622
0.007828
0.021526
0.023483
0.017613
0.046967
0.060665
0.060665
0.054795
0.019569
0.013699
0.015656
0.019569
0.041096
0.033268
0.029354
0.035225
0.060665
0.052838
0.005871
0.017613
0.029354
1
5,097
G
A
T
G
T
C
A
A
A
G
A
C
A
A
A
C
T
G
G
G
G
G
T
T
C
T
T
C
A
G
G
A
T
G
T
T
C
A
C
C
C
A
G
A
A
C
C
G
G
A
G
A
G
G
A
A
G
G
C
T
G
T
G
G
G
A
0.019569
0.021526
0.037182
0
0.035225
0.043053
0.003914
0.017613
0.043053
0.050881
0.076321
0.001957
0.023483
0.021526
0.029354
0.027397
0.078278
0.050881
0.062622
0.009785
0.023483
0.009785
0.015656
0.054795
0.02544
0.041096
0.031311
0.052838
0.041096
0.009785
0.003914
0.037182
1
5,098
C
A
G
C
C
C
T
G
T
T
C
G
T
C
T
T
C
T
G
T
A
C
C
A
A
G
A
G
C
C
G
A
C
G
T
G
C
T
G
A
G
C
G
T
T
A
C
T
G
G
C
A
G
A
A
G
A
C
G
C
T
G
C
T
G
T
0.013699
0.013699
0.027397
0.011742
0.021526
0.02544
0.015656
0.013699
0.041096
0.052838
0.066536
0.007828
0.021526
0.017613
0.021526
0.02544
0.080235
0.052838
0.076321
0.027397
0.009785
0.02544
0.005871
0.060665
0.02544
0.02544
0.050881
0.062622
0.060665
0.011742
0.005871
0.021526
1
5,099
G
G
C
C
C
G
T
T
G
G
A
C
G
G
T
G
G
G
A
C
C
C
T
G
C
T
G
A
C
C
A
T
C
C
G
A
G
G
A
A
G
G
A
A
C
C
T
G
G
G
C
C
G
G
C
G
G
C
T
C
A
G
T
G
A
G
0.001957
0.005871
0.021526
0.009785
0.033268
0.035225
0.019569
0.029354
0.031311
0.043053
0.066536
0.001957
0.015656
0.011742
0.011742
0.076321
0.086106
0.07045
0.050881
0.02544
0.011742
0.005871
0.005871
0.056751
0.021526
0.029354
0.050881
0.080235
0.046967
0.007828
0.003914
0.031311
1
5,100
C
T
C
C
A
G
G
C
T
G
C
G
G
T
T
G
C
G
C
G
G
G
A
A
G
A
A
G
G
A
G
C
T
G
C
C
G
T
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A
C
C
G
G
T
G
T
A
C
G
T
G
G
C
G
C
C
C
A
C
G
A
G
C
A
A
0
0.023483
0.027397
0
0.021526
0.039139
0.041096
0.005871
0.017613
0.048924
0.039139
0
0.015656
0.011742
0.021526
0.043053
0.04501
0.04501
0.060665
0.078278
0.031311
0.093933
0.009785
0.031311
0.027397
0.02544
0.039139
0.088063
0.035225
0.015656
0.001957
0.015656
1
5,101
G
A
C
C
A
C
A
A
T
G
G
G
G
A
G
A
C
C
T
T
C
A
G
G
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T
G
C
T
G
C
T
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C
A
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C
C
A
A
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C
T
A
T
A
A
C
C
A
A
C
A
T
A
T
A
C
A
A
A
G
T
T
0.091977
0.04501
0.041096
0.060665
0.04501
0.02544
0.005871
0.033268
0.033268
0.035225
0.023483
0.046967
0.023483
0.041096
0.04501
0.023483
0.035225
0.035225
0.009785
0
0
0.005871
0.027397
0.021526
0.027397
0.013699
0.031311
0.017613
0.015656
0.027397
0.074364
0.037182
1
5,102
T
C
A
A
G
G
T
C
T
G
C
C
C
T
T
T
G
C
T
C
T
G
G
T
A
T
G
T
A
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T
A
C
A
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T
A
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C
T
T
G
T
T
C
G
T
A
A
G
C
A
C
C
T
T
T
C
A
0.052838
0.031311
0.056751
0.050881
0.037182
0.029354
0.003914
0.043053
0.052838
0.029354
0.037182
0.027397
0.015656
0.031311
0.041096
0.021526
0.043053
0.033268
0.023483
0.001957
0.001957
0.003914
0.02544
0.037182
0.046967
0.017613
0.029354
0.019569
0.02544
0.043053
0.048924
0.037182
1
5,103
A
T
T
T
T
C
T
C
T
C
T
C
A
T
T
T
G
C
T
T
T
A
G
C
C
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C
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C
T
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A
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G
T
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C
C
A
A
A
A
C
T
T
C
C
C
A
G
T
C
A
G
T
C
T
C
0.091977
0.039139
0.04501
0.07045
0.035225
0.021526
0.007828
0.041096
0.04501
0.023483
0.027397
0.031311
0.027397
0.029354
0.048924
0.013699
0.041096
0.035225
0.007828
0.001957
0.001957
0
0.031311
0.019569
0.043053
0.021526
0.015656
0.023483
0.017613
0.031311
0.062622
0.046967
1
5,104
C
C
G
C
T
G
C
T
G
C
A
G
G
C
G
C
T
C
C
A
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G
G
C
C
G
C
C
A
A
C
G
C
T
C
C
C
A
G
C
C
C
0.007828
0.009785
0.021526
0.003914
0.013699
0.029354
0.031311
0.011742
0.027397
0.050881
0.060665
0
0.011742
0.015656
0.007828
0.029354
0.052838
0.041096
0.072407
0.062622
0.037182
0.064579
0.005871
0.07045
0.023483
0.041096
0.031311
0.072407
0.062622
0.007828
0.001957
0.019569
1
5,105
T
T
A
C
A
A
T
T
C
C
C
A
T
T
C
G
T
T
T
C
A
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G
A
A
A
A
A
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A
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T
T
T
T
A
A
A
G
C
T
0.111546
0.035225
0.039139
0.062622
0.041096
0.033268
0.009785
0.029354
0.027397
0.031311
0.021526
0.056751
0.027397
0.041096
0.041096
0.021526
0.027397
0.031311
0.007828
0.007828
0.005871
0.003914
0.029354
0.013699
0.031311
0.011742
0.021526
0.013699
0.013699
0.046967
0.066536
0.037182
1
5,106
G
A
A
C
T
A
G
A
T
C
A
A
C
A
G
G
T
T
T
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C
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T
C
A
A
A
G
A
A
A
A
T
A
A
G
T
T
T
G
A
A
T
0.068493
0.035225
0.043053
0.072407
0.060665
0.011742
0
0.048924
0.039139
0.015656
0.021526
0.099804
0.031311
0.035225
0.035225
0.021526
0.031311
0.013699
0.011742
0
0.003914
0
0.039139
0.011742
0.046967
0.015656
0.005871
0.001957
0.021526
0.046967
0.068493
0.041096
1
5,107
T
C
T
G
A
A
A
C
G
A
G
A
A
G
G
T
G
T
T
T
G
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G
G
G
T
G
T
G
G
T
T
G
C
T
G
G
G
A
T
C
T
C
0.121331
0.035225
0.048924
0.060665
0.048924
0.011742
0.005871
0.046967
0.035225
0.023483
0.007828
0.088063
0.011742
0.043053
0.04501
0.027397
0.021526
0.021526
0.009785
0.001957
0.001957
0.001957
0.031311
0.011742
0.050881
0.009785
0.033268
0.005871
0.013699
0.041096
0.048924
0.033268
1
5,108
T
A
A
C
A
C
G
T
T
T
T
G
T
A
C
T
A
A
G
A
T
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C
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G
G
A
A
G
A
C
T
G
G
C
T
G
C
A
C
A
A
A
T
0.119374
0.033268
0.046967
0.066536
0.048924
0.009785
0.005871
0.046967
0.035225
0.021526
0.007828
0.099804
0.011742
0.043053
0.041096
0.027397
0.021526
0.021526
0.009785
0
0.001957
0
0.031311
0.011742
0.050881
0.009785
0.027397
0.005871
0.013699
0.041096
0.054795
0.033268
1
5,109
A
T
T
G
T
C
A
T
A
T
A
C
C
T
T
A
T
A
T
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C
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G
C
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C
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G
T
C
A
T
C
A
C
A
C
T
G
A
G
G
A
T
T
T
G
C
0.133072
0.035225
0.035225
0.082192
0.039139
0.021526
0.003914
0.019569
0.048924
0.017613
0.029354
0.054795
0.031311
0.043053
0.037182
0.009785
0.039139
0.019569
0.001957
0
0
0
0.029354
0.011742
0.056751
0.011742
0.033268
0.003914
0.023483
0.029354
0.058708
0.039139
1
5,110
G
G
C
C
A
T
G
A
G
G
T
C
T
T
C
C
A
A
G
C
T
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T
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C
T
C
A
G
T
G
A
C
A
G
A
A
T
C
T
T
C
T
T
A
0.097847
0.033268
0.056751
0.078278
0.039139
0.013699
0.001957
0.031311
0.054795
0.021526
0.02544
0.058708
0.021526
0.033268
0.043053
0.013699
0.029354
0.021526
0.011742
0.001957
0.001957
0.001957
0.02544
0.023483
0.060665
0.019569
0.013699
0.011742
0.023483
0.019569
0.064579
0.04501
1
5,111
C
T
C
T
T
G
G
G
T
G
A
T
C
G
G
G
A
T
C
T
A
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A
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A
C
C
T
C
T
G
C
A
A
A
G
G
T
A
C
T
A
T
G
T
0.068493
0.029354
0.052838
0.037182
0.031311
0.023483
0.007828
0.037182
0.052838
0.02544
0.029354
0.031311
0.046967
0.02544
0.043053
0.031311
0.046967
0.039139
0.031311
0.003914
0.009785
0.005871
0.019569
0.027397
0.037182
0.011742
0.043053
0.023483
0.02544
0.027397
0.039139
0.035225
1
5,112
A
T
G
T
T
A
A
G
T
G
A
A
T
A
A
A
T
A
A
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A
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C
C
C
A
T
T
T
T
C
T
T
A
C
A
G
T
G
A
G
G
G
0.154599
0.039139
0.048924
0.091977
0.037182
0.013699
0.001957
0.037182
0.027397
0.019569
0.015656
0.072407
0.02544
0.037182
0.035225
0.017613
0.017613
0.015656
0.003914
0
0.001957
0.003914
0.021526
0.011742
0.041096
0.007828
0.013699
0.001957
0.015656
0.02544
0.101761
0.041096
1
5,113
T
A
C
T
C
A
C
T
A
G
G
T
A
G
T
A
G
C
G
G
C
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G
T
C
G
C
T
C
G
T
G
A
G
C
C
C
C
G
C
G
G
C
0.001957
0.023483
0.009785
0
0.003914
0.017613
0.039139
0.019569
0.011742
0.048924
0.033268
0
0.011742
0.007828
0.007828
0.019569
0.050881
0.035225
0.131115
0.101761
0.02544
0.080235
0.007828
0.04501
0.02544
0.02544
0.037182
0.091977
0.060665
0.015656
0
0.009785
1
5,114
G
A
A
T
T
C
A
G
T
G
G
G
A
G
A
G
A
G
A
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G
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T
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C
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G
A
G
C
C
C
T
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C
T
C
C
A
A
G
C
T
A
A
G
T
0.068493
0.039139
0.031311
0.04501
0.041096
0.021526
0.011742
0.023483
0.052838
0.043053
0.031311
0.021526
0.019569
0.039139
0.035225
0.029354
0.054795
0.043053
0.021526
0.007828
0.005871
0.001957
0.027397
0.039139
0.048924
0.015656
0.04501
0.027397
0.033268
0.013699
0.031311
0.029354
1
5,115
A
T
A
C
A
C
C
A
A
A
C
C
T
G
C
A
T
C
C
A
G
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T
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C
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C
C
T
G
A
A
A
G
A
G
A
A
C
A
G
G
C
C
A
G
T
T
0.02544
0.027397
0.041096
0.015656
0.041096
0.031311
0.005871
0.035225
0.043053
0.031311
0.056751
0.027397
0.021526
0.031311
0.029354
0.046967
0.060665
0.054795
0.039139
0.007828
0.003914
0.005871
0.019569
0.04501
0.041096
0.02544
0.031311
0.041096
0.04501
0.013699
0.013699
0.041096
1
5,116
G
G
T
T
G
A
G
A
A
G
C
T
C
C
C
A
G
A
T
C
A
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C
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G
G
G
C
C
A
C
G
A
C
G
G
T
A
T
G
A
G
A
A
T
0.021526
0.015656
0.04501
0.011742
0.033268
0.027397
0.005871
0.031311
0.035225
0.054795
0.050881
0.015656
0.021526
0.029354
0.033268
0.039139
0.064579
0.064579
0.054795
0.017613
0.003914
0.003914
0.011742
0.048924
0.031311
0.02544
0.033268
0.052838
0.052838
0.017613
0.009785
0.035225
1
5,117
G
T
G
A
C
A
T
A
C
C
A
T
G
A
T
C
T
T
G
G
C
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T
G
A
T
A
C
A
C
A
C
T
C
T
A
T
T
T
T
C
C
T
0.037182
0.02544
0.035225
0.017613
0.048924
0.02544
0.003914
0.031311
0.033268
0.046967
0.04501
0.017613
0.02544
0.037182
0.035225
0.052838
0.064579
0.046967
0.04501
0.007828
0.005871
0.009785
0.021526
0.037182
0.035225
0.019569
0.046967
0.04501
0.029354
0.011742
0.007828
0.046967
1
5,118
G
T
A
G
A
G
C
A
G
G
C
C
C
A
T
G
G
G
G
A
T
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C
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T
G
C
C
G
T
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T
G
G
C
A
G
G
A
C
T
T
C
T
G
0.027397
0.021526
0.052838
0.033268
0.033268
0.029354
0.001957
0.031311
0.054795
0.035225
0.052838
0.02544
0.027397
0.019569
0.046967
0.029354
0.064579
0.050881
0.039139
0.003914
0
0.001957
0.023483
0.033268
0.052838
0.02544
0.037182
0.031311
0.046967
0.019569
0.009785
0.037182
1
5,119
A
C
A
T
A
C
T
G
T
G
T
C
A
T
C
T
C
T
G
A
A
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G
A
A
C
A
A
A
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A
A
A
A
G
T
T
G
C
C
C
G
C
0.054795
0.037182
0.043053
0.017613
0.048924
0.037182
0.007828
0.027397
0.029354
0.037182
0.041096
0.021526
0.013699
0.056751
0.035225
0.037182
0.04501
0.056751
0.037182
0.011742
0.003914
0
0.015656
0.033268
0.048924
0.027397
0.027397
0.023483
0.048924
0.019569
0.013699
0.041096
1
5,120
A
C
C
C
A
G
C
A
A
G
C
G
C
A
T
C
A
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C
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T
T
T
T
C
C
T
C
C
T
G
G
T
T
C
A
C
C
A
T
0.023483
0.02544
0.041096
0.017613
0.023483
0.035225
0.007828
0.023483
0.043053
0.039139
0.046967
0.009785
0.04501
0.048924
0.023483
0.033268
0.062622
0.058708
0.052838
0.007828
0.011742
0.011742
0.019569
0.029354
0.041096
0.021526
0.043053
0.039139
0.039139
0.009785
0.021526
0.043053
1
5,121
C
T
G
A
A
G
A
A
A
T
G
A
G
C
A
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C
C
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G
G
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G
G
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A
C
C
A
A
G
T
T
A
T
0.064579
0.029354
0.050881
0.033268
0.019569
0.031311
0.001957
0.019569
0.052838
0.046967
0.04501
0.009785
0.027397
0.046967
0.035225
0.021526
0.046967
0.041096
0.04501
0.005871
0.007828
0
0.021526
0.04501
0.056751
0.013699
0.04501
0.021526
0.037182
0.007828
0.023483
0.04501
1
5,122
G
A
T
C
T
G
C
A
G
C
A
T
G
A
C
A
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A
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C
C
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A
A
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C
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A
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A
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G
G
C
A
A
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T
A
T
0.021526
0.013699
0.04501
0.017613
0.029354
0.021526
0.001957
0.02544
0.056751
0.052838
0.04501
0.02544
0.031311
0.031311
0.033268
0.035225
0.064579
0.062622
0.052838
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0.005871
0.007828
0.005871
0.066536
0.033268
0.019569
0.035225
0.043053
0.050881
0.009785
0.009785
0.037182
1
5,123
C
T
T
T
G
G
C
A
G
C
C
G
G
G
T
G
C
A
C
C
G
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A
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T
C
T
C
T
T
C
C
T
G
G
C
T
G
C
A
G
G
T
G
G
0.015656
0.013699
0.046967
0.007828
0.029354
0.029354
0.005871
0.041096
0.046967
0.046967
0.050881
0.017613
0.027397
0.027397
0.02544
0.048924
0.064579
0.050881
0.056751
0.011742
0.005871
0
0.015656
0.058708
0.035225
0.021526
0.037182
0.041096
0.043053
0.021526
0.007828
0.046967
1
5,124
C
A
C
C
C
G
G
C
T
G
C
C
A
A
A
G
T
A
G
C
T
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G
C
T
G
A
T
C
T
G
A
G
A
A
G
A
G
A
G
C
A
A
0.02544
0.015656
0.04501
0.009785
0.029354
0.035225
0.005871
0.031311
0.050881
0.037182
0.056751
0.011742
0.031311
0.02544
0.02544
0.048924
0.062622
0.054795
0.062622
0.011742
0.005871
0
0.011742
0.056751
0.035225
0.021526
0.035225
0.041096
0.046967
0.015656
0.009785
0.043053
1
5,125
C
G
C
C
G
G
T
A
G
G
G
G
A
C
G
C
G
C
C
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A
C
G
G
G
T
G
G
C
G
G
C
G
G
T
C
G
G
G
G
A
0.027397
0.015656
0.027397
0.005871
0.019569
0.033268
0.029354
0.021526
0.023483
0.046967
0.046967
0.005871
0.005871
0.013699
0.023483
0.029354
0.052838
0.027397
0.052838
0.060665
0.023483
0.093933
0.017613
0.039139
0.013699
0.033268
0.054795
0.074364
0.027397
0.023483
0.011742
0.017613
1
5,126
C
G
C
C
G
G
T
A
G
G
G
G
A
C
G
C
G
C
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C
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G
G
T
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C
G
G
T
C
G
G
G
G
C
0.027397
0.015656
0.027397
0.005871
0.019569
0.033268
0.029354
0.021526
0.023483
0.046967
0.046967
0.005871
0.005871
0.013699
0.023483
0.029354
0.052838
0.027397
0.052838
0.060665
0.023483
0.093933
0.017613
0.039139
0.013699
0.033268
0.054795
0.074364
0.027397
0.023483
0.011742
0.017613
1
5,127
G
C
C
C
C
G
A
C
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C
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C
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C
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T
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C
C
T
A
C
C
G
G
C
T
0.027397
0.015656
0.027397
0.005871
0.019569
0.033268
0.029354
0.021526
0.023483
0.046967
0.04501
0.005871
0.005871
0.013699
0.023483
0.029354
0.052838
0.027397
0.052838
0.060665
0.023483
0.093933
0.017613
0.039139
0.013699
0.035225
0.054795
0.074364
0.027397
0.023483
0.011742
0.017613
1
5,128
T
C
T
G
A
T
C
A
T
G
G
G
C
C
C
A
T
G
T
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C
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C
C
T
A
A
C
A
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A
C
T
T
C
A
C
G
T
T
C
A
A
0.064579
0.037182
0.039139
0.041096
0.041096
0.029354
0.011742
0.019569
0.056751
0.019569
0.035225
0.027397
0.035225
0.048924
0.031311
0.027397
0.048924
0.039139
0.037182
0.011742
0
0
0.015656
0.027397
0.043053
0.011742
0.039139
0.031311
0.02544
0.02544
0.043053
0.035225
1
5,129
T
C
A
G
G
A
C
A
C
C
T
C
C
T
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C
C
T
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T
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G
T
C
T
G
T
C
A
C
C
A
A
T
G
A
G
G
A
T
G
T
0.058708
0.033268
0.04501
0.035225
0.050881
0.037182
0.005871
0.037182
0.052838
0.021526
0.043053
0.027397
0.02544
0.02544
0.04501
0.039139
0.052838
0.041096
0.013699
0.001957
0.003914
0
0.021526
0.035225
0.033268
0.031311
0.021526
0.027397
0.021526
0.027397
0.037182
0.046967
1
5,130
T
C
T
C
A
C
C
T
G
A
C
A
T
G
G
T
G
G
T
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T
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C
T
G
G
G
T
A
A
C
A
T
C
C
T
C
A
T
T
G
A
0.050881
0.027397
0.043053
0.043053
0.046967
0.039139
0.007828
0.035225
0.046967
0.02544
0.043053
0.039139
0.027397
0.027397
0.041096
0.039139
0.046967
0.043053
0.013699
0.001957
0.003914
0.001957
0.027397
0.033268
0.027397
0.029354
0.019569
0.027397
0.021526
0.031311
0.043053
0.04501
1
5,131
G
T
G
A
A
A
G
G
G
G
C
T
C
G
T
T
T
T
G
T
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C
C
A
C
T
C
A
T
C
A
C
T
T
T
T
G
T
T
G
A
A
0.041096
0.02544
0.04501
0.033268
0.043053
0.023483
0.001957
0.033268
0.058708
0.021526
0.043053
0.023483
0.037182
0.031311
0.039139
0.037182
0.054795
0.060665
0.039139
0.001957
0.003914
0
0.013699
0.04501
0.046967
0.021526
0.02544
0.027397
0.054795
0.015656
0.017613
0.033268
1
5,132
C
T
T
G
G
C
A
C
C
A
T
G
C
C
G
G
A
T
G
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G
A
C
A
T
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A
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G
A
A
G
A
G
T
T
A
C
T
0.033268
0.019569
0.046967
0.011742
0.041096
0.033268
0.005871
0.035225
0.050881
0.029354
0.054795
0.013699
0.023483
0.041096
0.027397
0.043053
0.048924
0.048924
0.043053
0.011742
0.001957
0.003914
0.019569
0.054795
0.031311
0.02544
0.037182
0.035225
0.048924
0.027397
0.017613
0.033268
1
5,133
C
G
C
A
T
T
T
G
C
T
G
A
G
G
C
A
A
C
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A
G
G
T
G
A
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G
A
C
C
T
C
A
T
G
T
T
T
0.041096
0.021526
0.046967
0.013699
0.043053
0.031311
0.005871
0.033268
0.046967
0.031311
0.054795
0.013699
0.021526
0.04501
0.023483
0.041096
0.052838
0.04501
0.039139
0.011742
0.001957
0.003914
0.017613
0.048924
0.037182
0.02544
0.037182
0.033268
0.046967
0.02544
0.021526
0.037182
1
5,134
A
A
G
G
T
G
C
T
T
A
G
A
G
C
T
C
A
T
G
A
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A
A
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C
A
G
A
T
C
C
A
A
A
T
G
C
T
G
A
G
T
0.050881
0.023483
0.043053
0.019569
0.031311
0.035225
0.001957
0.023483
0.048924
0.041096
0.060665
0.013699
0.015656
0.035225
0.033268
0.023483
0.054795
0.052838
0.050881
0.005871
0.005871
0.005871
0.029354
0.048924
0.031311
0.031311
0.027397
0.046967
0.037182
0.013699
0.021526
0.035225
1
5,135
T
T
T
C
T
G
T
G
C
T
T
C
A
C
C
A
G
G
G
T
T
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C
T
T
C
C
A
C
A
C
G
T
G
C
C
C
G
A
A
T
C
T
A
0.048924
0.031311
0.04501
0.037182
0.035225
0.02544
0.007828
0.021526
0.04501
0.023483
0.048924
0.019569
0.04501
0.035225
0.043053
0.029354
0.054795
0.054795
0.04501
0.005871
0.005871
0
0.015656
0.021526
0.050881
0.013699
0.039139
0.035225
0.048924
0.015656
0.019569
0.031311
1
5,136
T
T
G
T
G
G
A
T
G
A
C
A
T
C
A
T
C
C
A
A
C
C
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G
T
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C
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A
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C
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G
C
T
G
T
G
A
C
C
T
G
G
A
T
G
T
C
T
T
G
T
0.048924
0.031311
0.046967
0.041096
0.037182
0.023483
0.007828
0.023483
0.04501
0.023483
0.04501
0.021526
0.043053
0.035225
0.043053
0.029354
0.056751
0.054795
0.041096
0.003914
0.003914
0
0.015656
0.019569
0.048924
0.011742
0.041096
0.037182
0.043053
0.019569
0.02544
0.031311
1
5,137
T
C
T
T
T
T
C
C
T
T
T
G
A
T
T
T
G
T
T
T
A
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C
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C
C
A
A
G
G
A
C
G
T
T
G
T
A
C
C
T
T
C
T
C
0.088063
0.031311
0.041096
0.054795
0.035225
0.02544
0.007828
0.023483
0.041096
0.015656
0.037182
0.023483
0.04501
0.039139
0.039139
0.029354
0.046967
0.046967
0.031311
0.003914
0.007828
0
0.013699
0.015656
0.048924
0.009785
0.039139
0.027397
0.037182
0.021526
0.039139
0.033268
1
5,138
G
C
A
A
T
T
T
G
T
A
T
G
A
A
T
A
T
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G
G
A
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A
G
T
C
A
T
T
T
T
T
C
T
G
A
T
G
A
T
T
T
T
0.084149
0.031311
0.031311
0.093933
0.046967
0.011742
0
0.029354
0.050881
0.007828
0.019569
0.072407
0.054795
0.043053
0.04501
0.019569
0.035225
0.019569
0.003914
0
0.003914
0
0.017613
0.023483
0.050881
0.005871
0.015656
0.007828
0.019569
0.031311
0.062622
0.060665
1
5,139
T
C
C
T
G
G
C
A
G
T
G
C
A
G
C
A
G
G
T
A
C
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A
G
C
A
C
C
T
T
G
A
G
C
A
G
T
G
C
C
G
G
G
0.003914
0.009785
0.015656
0.013699
0.021526
0.033268
0.019569
0.023483
0.023483
0.066536
0.052838
0.005871
0.019569
0.023483
0.021526
0.056751
0.09589
0.060665
0.043053
0.027397
0.005871
0.029354
0.011742
0.04501
0.013699
0.021526
0.082192
0.068493
0.037182
0.009785
0.003914
0.033268
1
5,140
G
G
A
C
C
C
G
G
C
A
C
T
G
C
T
C
A
A
G
G
T
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C
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G
A
G
T
A
C
C
T
G
C
T
G
C
A
C
T
G
C
C
T
0.003914
0.009785
0.015656
0.013699
0.021526
0.033268
0.019569
0.023483
0.021526
0.068493
0.052838
0.005871
0.019569
0.023483
0.021526
0.056751
0.097847
0.060665
0.043053
0.027397
0.005871
0.029354
0.011742
0.041096
0.013699
0.021526
0.084149
0.07045
0.035225
0.009785
0.003914
0.033268
1
5,141
A
A
A
A
C
T
G
G
A
T
G
G
T
G
A
G
G
G
C
A
C
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C
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C
A
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G
C
T
T
G
T
A
T
G
T
G
A
0.066536
0.02544
0.035225
0.035225
0.031311
0.043053
0.009785
0.021526
0.041096
0.019569
0.037182
0.035225
0.027397
0.046967
0.037182
0.033268
0.039139
0.058708
0.058708
0.009785
0.001957
0.005871
0.015656
0.029354
0.031311
0.029354
0.029354
0.027397
0.035225
0.015656
0.027397
0.039139
1
5,142
T
G
A
G
T
G
G
C
C
T
C
A
T
C
C
C
A
C
C
C
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A
A
T
T
C
A
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C
A
T
G
C
G
G
G
T
0.015656
0.007828
0.037182
0.009785
0.02544
0.031311
0.017613
0.021526
0.054795
0.066536
0.058708
0.005871
0.009785
0.017613
0.017613
0.039139
0.066536
0.041096
0.056751
0.019569
0.007828
0.029354
0.017613
0.080235
0.023483
0.031311
0.037182
0.043053
0.04501
0.013699
0.013699
0.037182
1
5,143
T
G
T
A
T
T
G
C
T
C
C
C
G
C
A
T
G
G
C
G
C
T
G
A
A
T
T
C
C
T
C
C
T
G
C
C
C
A
G
C
T
G
T
G
T
C
C
A
G
A
A
C
T
G
G
G
G
T
G
G
G
A
T
G
A
C
0.023483
0.007828
0.037182
0.011742
0.02544
0.031311
0.017613
0.019569
0.052838
0.066536
0.056751
0.005871
0.011742
0.017613
0.017613
0.041096
0.064579
0.041096
0.056751
0.019569
0.007828
0.029354
0.017613
0.076321
0.023483
0.031311
0.037182
0.043053
0.043053
0.013699
0.013699
0.037182
1
5,144
A
C
C
G
C
A
G
C
C
T
C
C
C
T
C
A
C
C
C
A
T
G
C
C
C
T
A
T
G
C
C
T
C
C
T
G
C
C
A
G
A
T
G
G
C
G
G
C
A
G
C
C
G
C
A
G
C
G
G
C
T
G
C
A
G
T
0
0.009785
0.019569
0.001957
0.015656
0.023483
0.02544
0.013699
0.015656
0.039139
0.041096
0.001957
0.005871
0.02544
0.013699
0.033268
0.048924
0.033268
0.080235
0.109589
0.015656
0.099804
0.013699
0.027397
0.017613
0.007828
0.062622
0.142857
0.017613
0.027397
0
0.009785
1
5,145
G
A
G
G
C
T
C
A
C
G
C
T
G
T
C
C
G
G
C
A
T
C
T
A
C
C
A
G
T
A
C
A
T
C
A
T
C
G
C
G
A
A
G
T
T
C
C
C
G
T
T
C
T
A
C
G
A
G
A
A
G
A
A
T
A
G
0.005871
0.013699
0.039139
0.003914
0.015656
0.021526
0.019569
0.017613
0.033268
0.041096
0.035225
0.003914
0.017613
0.029354
0.021526
0.017613
0.033268
0.033268
0.068493
0.084149
0.035225
0.088063
0.011742
0.043053
0.035225
0.021526
0.031311
0.105675
0.027397
0.021526
0.001957
0.021526
1
5,146
G
C
C
G
G
A
C
A
G
C
G
T
G
A
G
C
C
T
C
T
T
C
T
C
C
G
C
G
C
T
C
T
C
G
C
G
G
A
T
C
G
C
C
A
T
G
G
C
G
A
T
G
A
G
C
G
C
C
A
C
G
T
A
C
G
T
0.005871
0.013699
0.035225
0.003914
0.015656
0.021526
0.019569
0.015656
0.035225
0.043053
0.037182
0.003914
0.017613
0.029354
0.019569
0.015656
0.035225
0.033268
0.058708
0.086106
0.033268
0.097847
0.011742
0.048924
0.031311
0.021526
0.029354
0.105675
0.029354
0.021526
0.001957
0.021526
1