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Chronobiology of chronic pain: focus on diurnal rhythmicity of neuropathic pain. | PURPOSE OF REVIEW
Although circadian rhythmicity has long been recognized in various nociceptive pain conditions such as arthritis, diurnal pain patterns in neuropathic conditions have only recently been described. The purpose of this article is to review emerging evidence and discuss future research to further underst... | 10.1097/SPC.0000000000000085 | 25,111,256 | D000700:Analgesics; D059350:Chronic Pain; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D006801:Humans; D009437:Neuralgia; D059226:Nociceptive Pain; D010147:Pain Measurement | Current opinion in supportive and palliative care | 2,014 | D000700:Analgesics |
Grafting Watermelon Onto Pumpkin Increases Chilling Tolerance by Up Regulating Arginine Decarboxylase to Increase Putrescine Biosynthesis. | Low temperature is a major environmental factor that severely impairs plant growth and productivity. Watermelon (Citrullus lanatus) is a chilling-sensitive crop. Grafting of watermelon onto pumpkin rootstock is an effective technique to increase the chilling tolerance of watermelon when exposure to short-time chilling ... | 10.3389/fpls.2021.812396 | 35,242,149 | Frontiers in plant science | 2,021 | ||
An overview of elder abuse and neglect in Australia. | Only relatively recently has the issue of elder abuse come to prominence in Australia. Until the late 1980s it was a hidden problem with little knowledge of its presence. Attention was drawn to elder abuse after the publication of a number of reports and research projects, allowing the development of responses at natio... | 10.1080/08946560801974521 | 18,928,212 | D000368:Aged; D004552:Elder Abuse; D006291:Health Policy; D006299:Health Services for the Aged; D006801:Humans; D009626:Terminology as Topic | Journal of elder abuse & neglect | 2,008 | |
Hypertonic saline impedes tumor cell-endothelial cell interaction by reducing adhesion molecule and laminin expression. | BACKGROUND
Hypertonic saline infusion dampens inflammatory responses and suppresses neutrophil-endothelial interaction by reducing adhesion molecule expression. This study tested the hypothesis that hypertonic saline attenuates tumor cell adhesion to the endothelium through a similar mechanism.
METHODS
Human colon ca... | 10.1016/j.surg.2003.11.011 | 15,232,542 | D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D002450:Cell Communication; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms; D042783:Endothelial Cells; D006801:Humans; D007797:Laminin; D012462:Saline Solution, Hypertonic | Surgery | 2,004 | D015815:Cell Adhesion Molecules; D007797:Laminin; D012462:Saline Solution, Hypertonic |
Superior Orbicularis Oris Muscle Activity in Children Surgically Treated for Bilateral Complete Cleft Lip and Palate. | The aim of this cross-sectional study was to evaluate the electromyographic activity of the superior orbicularis oris muscle both in children surgically treated for bilateral complete cleft lip and palate (BCCLP) as well as in subjects without BCCLP. The study comprised 77 children aged 6.6 to 12.5 years. All the patie... | 10.3390/jcm10081720 | 33,923,491 | Journal of clinical medicine | 2,021 | ||
[The efficacy of arteriovenous adventitial sheathotomy for macular edema in branch retinal vein occlusion]. | PURPOSE
To examine the efficacy of arteriovenous adventitial sheathotomy (or arteriovenous decompression) for macular edema (ME) in branch retinal vein occlusion (BRVO).
PATIENTS AND METHODS
Eighty-three patients (83 eyes) who had ME in BRVO for 26 weeks or less underwent pars plana vitrectomy and internal limiting m... | 15,103,950 | D000368:Aged; D000369:Aged, 80 and over; D019299:Decompression, Surgical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008269:Macular Edema; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D012170:Retinal Vein Occlusion; D013997:Time Factors; D016896:Treatment Outcome; D014... | Nippon Ganka Gakkai zasshi | 2,004 | ||
[Multidisciplinary-team approach in diagnosis and treatment of patients with chronic constipation]. | Chronic constipation is one of the common diseases in clinic. For the complicated causes and pathophysiology, the overall efficacy is not satisfactory in the traditional medical model. Multidisciplinary-team (MDT) approach is a new team medical model, which is also an important systematic and modular medical approach. ... | 29,280,112 | D003248:Constipation; D006801:Humans; D010348:Patient Care Team | Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | 2,017 | ||
Stroke Imaging Selection Modality and Endovascular Therapy Outcomes in the Early and Extended Time Windows. | BACKGROUND AND PURPOSE
Advanced imaging has been increasingly used for patient selection in endovascular stroke therapy. The impact of imaging selection modality on endovascular stroke therapy clinical outcomes in extended time window remains to be defined. We aimed to study this relationship and compare it to that not... | 10.1161/STROKEAHA.120.031685 | 33,430,634 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057510:Endovascular Procedures; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D018579:Patient Selection; D020521:Stroke; D017131:Thrombectomy; D016896:Treatment Outcome | Stroke | 2,021 | |
Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moiety. | Retinoid X receptor agonists (RXR agonists, rexinoids) are interesting candidates for the treatment of cancers such as tamoxifen-resistant breast cancer and taxol-resistant lung cancer. However, well-known RXR agonists possess a strong lipophilic character. In addition, although RXR has three subtypes, no subtype-selec... | 10.1002/cmdc.200700265 | 18,157,857 | D000818:Animals; D019440:Anti-Obesity Agents; D000970:Antineoplastic Agents; D019556:COS Cells; D002454:Cell Differentiation; D002522:Chlorocebus aethiops; D004357:Drug Synergism; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D009580:Nitroblue Tetrazolium; D010084:Oxidation-Reduction; D047... | ChemMedChem | 2,008 | D019440:Anti-Obesity Agents; D000970:Antineoplastic Agents; D047490:Retinoid X Receptor alpha; D049230:Retinoid X Receptor beta; D047491:Retinoid X Receptor gamma; D047488:Retinoid X Receptors; D013449:Sulfonamides; D009580:Nitroblue Tetrazolium |
Cross-sectional study to identify staphylococcal species isolated from teat and inguinal skin of different-aged dairy heifers. | The purpose of this study was to describe the prevalence and distribution of staphylococcal species on the teat and inguinal skin of dairy heifers across the various stages of the heifer life cycle. The cross-sectional study included 106 Holstein heifers with an age range of 0 d to 27 mo that were selected from 11 diff... | 10.3168/jds.2017-13974 | 29,397,170 | D000818:Animals; D002417:Cattle; D003430:Cross-Sectional Studies; D004463:Ecology; D005260:Female; D016015:Logistic Models; D008321:Mammary Glands, Animal; D008414:Mastitis, Bovine; D008923:Missouri; D009558:Nipples; D015995:Prevalence; D012867:Skin; D013203:Staphylococcal Infections; D013210:Staphylococcus | Journal of dairy science | 2,018 | |
Is there a need for shifting patients on long term nevirapine based regimens to efavirenz based regimens: a cross-sectional study? | Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the backbone of effective anti-retroviral therapy in the developing world. Efavirenz is the current NNRTI of choice due to reports of higher incidence of serious adverse events with nevirapine. Majority of patients with Human immunodeficiency virus (HIV) infe... | 10.5582/ddt.2018.01051 | 30,464,161 | D000328:Adult; D000480:Alkynes; D048588:Benzoxazines; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D003521:Cyclopropanes; D005260:Female; D015658:HIV Infections; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D019829:Nevirapine; D010349:Patient Compliance; D018894:Reverse Transcript... | Drug discoveries & therapeutics | 2,018 | D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine; C098320:efavirenz |
Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. | Loss-of-function activin receptor-like kinase 1 gene mutation (ALK1+/-) is associated with brain arteriovenous malformations (AVM) in hereditary hemorrhagic telangiectasia type 2. Other determinants of the lesional phenotype are unknown. In the present study, we investigated the influence of high vascular flow rates on... | 10.1152/ajpheart.00083.2008 | 18,835,925 | D030201:Activin Receptors, Type I; D030301:Activin Receptors, Type II; D000818:Animals; D001921:Brain; D002196:Capillaries; D002560:Cerebrovascular Circulation; D000229:Dependovirus; D004195:Disease Models, Animal; D005822:Genetic Vectors; D006830:Hydralazine; D021621:Imaging, Three-Dimensional; D007263:Infusions, Pare... | American journal of physiology. Heart and circulatory physiology | 2,008 | D042461:Vascular Endothelial Growth Factor A; D014665:Vasodilator Agents; D006830:Hydralazine; D009529:Nicardipine; D030201:Activin Receptors, Type I; D030301:Activin Receptors, Type II; C498931:Acvrl1 protein, mouse |
Fluorometric evidence for different stoichiometries for the Na+/Mg2+ exchange in Mg-loaded rat thymocytes. | The regulation of the cytosolic free magnesium concentration ([Mg2+]i) is a fundamental cellular process that requires magnesium extruding mechanisms. Here, we present evidence indicating that rat thymocytes are endowed with different Na/Mg exchange systems. Fluxes of magnesium were measured using the fluorescent magne... | 10.2741/1274 | 14,977,591 | D000818:Animals; D002478:Cells, Cultured; D005470:Fluorometry; D017136:Ion Transport; D007700:Kinetics; D008274:Magnesium; D008297:Male; D008564:Membrane Potentials; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium; D013950:Thymus Gland | Frontiers in bioscience : a journal and virtual library | 2,004 | D012964:Sodium; D008274:Magnesium |
TRPV1 Contributes to Modulate the Nitric Oxide Pathway and Oxidative Stress in the Isolated and Perfused Rat Heart during Ischemia and Reperfusion. | The transient vanilloid receptor potential type 1 (TRPV1) regulates neuronal and vascular functions mediated by nitric oxide (NO) and by the calcitonin gene-related peptide (CGRP). Here, we study the participation of TRPV1 in the regulation of myocardial injury caused by ischemia-reperfusion and in the control of NO, t... | 10.3390/molecules27031031 | 35,164,296 | D000818:Animals; D006321:Heart; D008297:Male; D015428:Myocardial Reperfusion Injury; D009569:Nitric Oxide; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction; D050916:TRPV Cation Channels | Molecules (Basel, Switzerland) | 2,022 | D050916:TRPV Cation Channels; C493922:Trpv1 protein, rat; D009569:Nitric Oxide |
Fecal Microbiota Transplantation Revealed a Pain-related Gut Microbiota Community in Ovariectomized Mice. | Higher sensitivity to pain is a common clinical symptom in postmenopausal females. The gut microbiota (GM) has recently been identified as participating in various pathophysiological processes and may change during menopause and contribute to multiple postmenopausal symptoms. Here, we investigated the possible correlat... | 10.1016/j.jpain.2023.02.003 | 36,796,501 | D005260:Female; D051379:Mice; D000818:Animals; D000069467:Fecal Microbiota Transplantation; D000069196:Gastrointestinal Microbiome; D006930:Hyperalgesia; D012336:RNA, Ribosomal, 16S; D010146:Pain | The journal of pain | 2,023 | D012336:RNA, Ribosomal, 16S |
Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells. | Chimeric antigen receptor (CAR) T cell therapy is an FDA-approved treatment for several hematologic malignancies, yet not all patients respond to this treatment. While some resistance mechanisms have been identified, cell death pathways in target cancer cells remain underexplored. Impairing mitochondrial apoptosis via ... | 10.1038/s41419-023-05727-x | 37,055,388 | D006801:Humans; D000076962:Receptors, Chimeric Antigen; D017209:Apoptosis; D020169:Caspases; D045744:Cell Line, Tumor; D050998:bcl-2 Homologous Antagonist-Killer Protein; D009369:Neoplasms | Cell death & disease | 2,023 | D000076962:Receptors, Chimeric Antigen; D020169:Caspases; D050998:bcl-2 Homologous Antagonist-Killer Protein |
Sustained sleep fragmentation results in delayed changes in hippocampal-dependent cognitive function associated with reduced dentate gyrus neurogenesis. | Sleep fragmentation (SF) is prevalent in human sleep-related disorders. In rats, sustained SF has a potent suppressive effect on adult hippocampal dentate gyrus (DG) neurogenesis. Adult-generated DG neurons progressively mature over several weeks, and participate in certain hippocampal-dependent cognitive functions. We... | 10.1016/j.neuroscience.2010.06.038 | 20,600,652 | D000818:Animals; D003071:Cognition; D018891:Dentate Gyrus; D006624:Hippocampus; D008297:Male; D055495:Neurogenesis; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012892:Sleep Deprivation; D012894:Sleep Stages; D013997:Time Factors | Neuroscience | 2,010 | |
Ovotestes and sexual reversal in racing pigeons. | The occurrence of ovotestes associated with male behavioral characteristics in two mature female racing pigeons (Columba livia) is recorded. An ovotestis developed in the area of the vestigial right gonad of one bird and within the functional left ovary of the second bird. | 17,422,628 | The Canadian veterinary journal = La revue veterinaire canadienne | 1,986 | |||
General practice and the new science emerging from the theories of 'chaos' and complexity. | This paper outlines the general practice world view and introduces the main features of the theories of 'chaos' and complexity. From this, analogies are drawn between general practice and the theories, which suggest a different way of understanding general practice and point to future developments in general practice r... | 10,071,407 | D003625:Data Collection; D005194:Family Practice; D005544:Forecasting; D006801:Humans; D008962:Models, Theoretical; D017711:Nonlinear Dynamics; D012106:Research; D006113:United Kingdom | The British journal of general practice : the journal of the Royal College of General Practitioners | 1,998 | ||
Fixed Points of Wegner-Wilson Flows and Many-Body Localization. | Many-body localization (MBL) is a phase of matter that is characterized by the absence of thermalization. Dynamical generation of a large number of local quantum numbers has been identified as one key characteristic of this phase, quite possibly the microscopic mechanism of breakdown of thermalization and the phase tra... | 10.1103/PhysRevLett.119.075701 | 28,949,663 | Physical review letters | 2,017 | ||
Evaluation of the Genetic Association and Expressions of Notch-2 /Jagged-1 in Patients with Type 2 Diabetes Mellitus. | BACKGROUND
Diabetes mellitus (DM) is the world's most common cause of chronic kidney diseases (CKD), with approximately 1 in 4 adults with DM having CKD and 1 out of 10 to 20% of DM patients die from CKD.
OBJECTIVE
The current study aims to investigate the correlation between Notch-2 and Jag-1expressions and specific... | 10.5455/medarh.2021.75.101-108 | 34,219,868 | D000328:Adult; D000368:Aged; D015415:Biomarkers; D003924:Diabetes Mellitus, Type 2; D003928:Diabetic Nephropathies; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D053583:Interleukin-1beta; D015850:Interleukin-6; D007493:Iraq; D000072100:Jagged-1 Protein; ... | Medical archives (Sarajevo, Bosnia and Herzegovina) | 2,021 | D015415:Biomarkers; D053583:Interleukin-1beta; D015850:Interleukin-6; C000606273:JAG1 protein, human; D000072100:Jagged-1 Protein; C497764:NOTCH2 protein, human; D051883:Receptor, Notch2 |
Clinical and microbiological investigations of anorexia nervosa. | Several studies have examined the relationship between anorexia nervosa and oral status. However, none has used control subjects. Furthermore, none has examined bacteriological data in these subjects to determine whether dietary restrictions, particularly of carbohydrates, change the levels of Streptococcus mutans and ... | 10.1111/j.1834-7819.1991.tb04722.x | 1,785,967 | D000328:Adult; D000856:Anorexia Nervosa; D016022:Case-Control Studies; D003731:Dental Caries; D003773:Dental Plaque; D002149:Energy Intake; D005260:Female; D005884:Gingival Hemorrhage; D005889:Gingival Recession; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007778:Lactobacillus; D010510:Periodontal Diseases; D0... | Australian dental journal | 1,991 | |
[THE REMOTE MONITORING OF ARTERIAL PRESSURE AND RATE OF HEARTBEATS]. | The article considers issues of necessity of development and implementation of remote monitoring of arterial blood pressure and rate of heartbeats as a mean of enhancing quality of medical care of patients. The main characteristics of development of specialized automated system as an integral component of the project i... | 26,411,169 | D018660:Blood Pressure Monitoring, Ambulatory; D006339:Heart Rate; D006801:Humans; D058998:Remote Sensing Technology | Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny | 2,015 | ||
The preliminary evaluation of degradation of substance P(SP) fragment's analogue less than Glu SP6-11 in the subcellular fractions from different areas of rat brain. | Peptidase(s) activity of different subcellular fractions isolated from cortex, hippocampus, midbrain, thalamus with hypothalamus, cerebellum and medulla oblongata exerted against less than Glu SP6-11 (3H-Phen8) was evaluated in "low-ionic" and similar (in composition) to both extracellular and intracellular conditions.... | 10.1016/0020-711x(85)90042-4 | 2,415,410 | D000818:Animals; D001711:Biotransformation; D001921:Brain; D005260:Female; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009842:Oligopeptides; D010446:Peptide Fragments; D010447:Peptide Hydrolases; D011761:Pyrrolidonecarboxylic Acid; D012313:RNA; D051381:Rats; D013347:Subcellular Fractions; D013373:... | The International journal of biochemistry | 1,985 | D009842:Oligopeptides; D010446:Peptide Fragments; D013373:Substance P; C026238:substance P (6-11), pGlu(6)-; D012313:RNA; D010447:Peptide Hydrolases; D011761:Pyrrolidonecarboxylic Acid |
Association of remote traumatic brain injury and military employment with late-life trajectories of depressive symptom severity. | BACKGROUND
Traumatic brain injury (TBI) and military service are common lifetime exposures among current older adults that may affect late-life mental health. The objective of the present study was to evaluate the association between TBI with loss of consciousness (LOC) and military employment and late-life depressive ... | 10.1016/j.jad.2020.12.003 | 33,348,181 | D000368:Aged; D000070642:Brain Injuries, Traumatic; D003863:Depression; D004651:Employment; D005260:Female; D006801:Humans; D008297:Male; D008889:Military Personnel; D012189:Retrospective Studies | Journal of affective disorders | 2,021 | |
[Carbohydrate metabolism in children with pulmonary tuberculosis]. | Examining carbohydrate metabolism in 59 children with pulmonary tuberculosis ascertained that to get tuberculosis naturally resulted in lower tissue sensitivity to insulin and in hyperinsulinemia. Effective treatment of children improves carbohydrate metabolism. However, there is no normalization of carbohydrate metabo... | 10,067,343 | D000293:Adolescent; D001786:Blood Glucose; D050260:Carbohydrate Metabolism; D002648:Child; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin; D011379:Prognosis; D011863:Radioimmunoassay; D014397:Tuberculosis, Pulmonary | Problemy tuberkuleza | 1,998 | D001786:Blood Glucose; D007328:Insulin | |
Relationship between ozone air pollution and daily suicide mortality: a time-stratified case-crossover study in Taipei. | Several studies suggested short-term exposure to air pollution might be associated with suicide mortality, although results have been inconsistent and vary depending upon the type of air contaminants. While seasonal variation associated with suicide was reported to occur and that in the spring and early summer there ar... | 10.1080/15287394.2019.1589109 | 30,870,114 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants; D000397:Air Pollution; D002423:Cause of Death; D018592:Cross-Over Studies; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010126:Ozone; D012621:Seasons; D013405:Suicide; D013624:Taiwan | Journal of toxicology and environmental health. Part A | 2,019 | D000393:Air Pollutants; D010126:Ozone |
MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis. | MLN64 is a protein that is highly expressed in certain breast carcinomas. The C terminus of MLN64 shares significant homology with the steroidogenic acute regulatory protein (StAR), which plays a key role in steroid hormone biosynthesis by enhancing the intramitochondrial translocation of cholesterol to the cholesterol... | 10.1073/pnas.94.16.8462 | 9,237,999 | D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002352:Carrier Proteins; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity; D010750:Phosphoproteins; D012313:RNA; D016415:Sequence Alignment; D017421:Sequence Analysis; D017386:Sequence Ho... | Proceedings of the National Academy of Sciences of the United States of America | 1,997 | D002352:Carrier Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins; C105684:STARD3 protein, human; D013256:Steroids; C090395:steroidogenic acute regulatory protein; D012313:RNA |
Does Peak Inspiratory Pressure Increase in the Prone Position? An Analysis Related to Body Mass Index. | PURPOSE
Percutaneous nephrolithotomy is commonly performed with the patient prone. There is concern that the prone position, especially in obese patients, negatively affects ventilation due to the restriction of chest compliance and respiratory mechanics. We analyzed the change in airway resistance between supine and p... | 25,983,193 | D015992:Body Mass Index; D005260:Female; D006801:Humans; D001239:Inhalation; D007320:Inspiratory Capacity; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009403:Nephrostomy, Percutaneous; D056888:Patient Positioning; D011312:Pressure; D016684:Prone Position; D012189:Retrospective Studies | The Journal of urology | 2,015 | ||
The role of BioGlue in thoracic surgery: a systematic review. | BACKGROUND
BioGlue is a commonly used sealant in thoracic surgery. Prolonged air leak and presence of bronchopleural fistulae (BPF) are often encountered in clinical practice. We therefore, investigated the role and the efficacy of BioGlue in these scenarios.
METHODS
A systematic review was conducted by searching Med... | 10.21037/jtd.2017.02.57 | 28,449,464 | Journal of thoracic disease | 2,017 | ||
The influence of intolerance of uncertainty on the correlation between the severity of symptoms and satisfaction with oral state in patients with burning mouth syndrome. | OBJECTIVE
Intolerance of uncertainty (IU) is thought to be involved with the psychological factors that influence the symptoms in patients with burning mouth syndrome (BMS) and affect their limited satisfaction with the treatments provided. However, the influence of IU on satisfaction has not been explored in detail. T... | 10.1007/s00784-022-04606-7 | 35,790,598 | D006801:Humans; D002054:Burning Mouth Syndrome; D010549:Personal Satisfaction; D035501:Uncertainty; D017060:Patient Satisfaction; D011795:Surveys and Questionnaires | Clinical oral investigations | 2,022 | |
Elevated circulating inflammatory markers in female patients with cardiac syndrome X. | BACKGROUND
The pathophysiological mechanism in cardiac syndrome X has been suggested as impairment in normal endothelial function of the coronary microvasculature, resulting in inadequate flow reserve. However, despite the extensive studies, the precise mechanisms in cardiac syndrome X remain unclear.
PURPOSE
The pre... | 10.1016/j.cyto.2007.09.005 | 17,945,505 | D000328:Adult; D001772:Blood Cell Count; D002097:C-Reactive Protein; D002908:Chronic Disease; D003326:Coronary Circulation; D004730:Endothelium, Vascular; D005260:Female; D006801:Humans; D007249:Inflammation; D018836:Inflammation Mediators; D015850:Interleukin-6; D017566:Microvascular Angina; D008875:Middle Aged; D0114... | Cytokine | 2,007 | C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D002097:C-Reactive Protein |
Intracellular interaction of newly synthesized nerve growth factor and its receptors. | In autocrine cells, both a ligand and its receptors are synthesized in the same cell, but their intracellular interaction is not well known. We examined it using PC84 cells, a mutant PC12 cell line expressing nerve growth factor (NGF). We have already reported that the intracellular precursor of TrkA was phosphorylated... | 23,410,755 | D000818:Animals; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases; D020932:Nerve Growth Factor; D009419:Nerve Tissue Proteins; D016716:PC12 Cells; D010766:Phosphorylation; D051381:Rats; D020917:Receptor, trkA; D017978:Receptors, Growth Factor; D017475:Receptors, Nerve Growth Factor | Biochemical and biophysical research communications | 2,013 | D009419:Nerve Tissue Proteins; D017978:Receptors, Growth Factor; D017475:Receptors, Nerve Growth Factor; C068313:Ngfr protein, rat; D020932:Nerve Growth Factor; D020917:Receptor, trkA; D020929:Mitogen-Activated Protein Kinase Kinases | |
Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. | Carnosine, homocarnosine, and anserine are present in high concentrations in the muscle and brain of many animals and humans. However, their exact function is not clear. The antioxidant activity of these compounds has been examined by testing their peroxyl radical-trapping ability at physiological concentrations. Carno... | 10.1073/pnas.85.9.3175 | 3,362,866 | D000578:Amidines; D000861:Anserine; D000975:Antioxidants; D001391:Azo Compounds; D001921:Brain; D002336:Carnosine; D002851:Chromatography, High Pressure Liquid; D003849:Deoxyguanosine; D004151:Dipeptides; D004563:Electrochemistry; D005609:Free Radicals; D006639:Histidine; D008054:Lipid Peroxides; D009132:Muscles; D0095... | Proceedings of the National Academy of Sciences of the United States of America | 1,988 | D000578:Amidines; D000975:Antioxidants; D001391:Azo Compounds; D004151:Dipeptides; D005609:Free Radicals; D008054:Lipid Peroxides; D009570:Nitriles; D012996:Solutions; C055792:2,2'-azobis(2,4-dimethylvaleronitrile); C005038:homocarnosine; D006639:Histidine; C046728:2,2'-azobis(2-amidinopropane); D002336:Carnosine; D003... |
The potential anti-inflammatory benefits of improving physical fitness in hypertension. | Hypertension is associated with an increased risk of stroke and atherosclerosis. In addition to elevated blood pressure, hypertension is characterized by neuroendocrine and immune activation, including elevated levels of C-reactive protein, inflammatory cytokines, and soluble adhesion molecules, which are predictive of... | 10.1097/HJH.0b013e328165ca67 | 17,620,945 | D015444:Exercise; D006801:Humans; D006973:Hypertension; D007249:Inflammation; D010809:Physical Fitness | Journal of hypertension | 2,007 | |
Social support and the persistence of complaints in chronic fatigue syndrome. | BACKGROUND
Several studies suggested that the surroundings of chronic fatigue syndrome (CFS) patients are of importance in the persistence of complaints. Contrary to what was expected, participation in support groups has not led to clinical improvement. The purpose of the present study was to describe social support in... | 10.1159/000076455 | 15,031,590 | D000293:Adolescent; D000328:Adult; D015928:Cognitive Behavioral Therapy; D015673:Fatigue Syndrome, Chronic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012944:Social Support; D011795:Surveys and Questionnaires | Psychotherapy and psychosomatics | 2,004 | |
Dysregulation of the glutamine transporter Slc38a3 (SNAT3) and ammoniagenic enzymes in obese, glucose-intolerant mice. | BACKGROUND/AIMS
Uric acid nephrolithiasis is prevalent among patients with type 2 diabetes and metabolic syndrome; it is correlated with an acidic urine and lower urinary ammonium excretion and is likely associated with insulin resistance. Insulin stimulates ammoniagenesis in renal cell lines via increased phosphate-de... | 10.1159/000363024 | 25,116,356 | D026921:Amino Acid Transport Systems, Neutral; D000641:Ammonia; D000818:Animals; D005951:Glucose Tolerance Test; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity; D060888:Real-Time Polymerase Chain Reaction | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2,014 | D026921:Amino Acid Transport Systems, Neutral; C403222:system N protein 1; D000641:Ammonia |
Activism Is an Essential Nursing Role. | Nursing has a long history of activism, yet nurses are often heard to express their dislike of "politics" and their desire to stay away from the tense and contentious situations associated with political activism. Nurses, however, have a fundamental duty to advocate on behalf of their patients and communities. In this ... | 10.1097/01.NAJ.0000979100.16233.cc | 37,732,670 | D006801:Humans; D006268:Health Facilities; D024802:Nurse's Role; D057766:Policy; D000074439:Political Activism; D011057:Politics | The American journal of nursing | 2,023 | |
Potential correlation between plasma total GIP levels and body mass index in Japanese patients with types 1 or 2 diabetes mellitus. | Glucose-dependent insulinotropic polypeptide (GIP) secretion in diabetic Europeans with type 1 (T1DM) and type 2 (T2DM) following test meal (TM) has been shown to be normal. In Japanese patients with T2DM, GIP secretion was also normal. We determined whether GIP secretin is influenced by various factors. Plasma gluc... | 10.1507/endocrj.ej11-0245 | 22,301,939 | D044466:Asian People; D001786:Blood Glucose; D015992:Body Mass Index; D002096:C-Peptide; D003922:Diabetes Mellitus, Type 1; D003924:Diabetes Mellitus, Type 2; D005260:Female; D005749:Gastric Inhibitory Polypeptide; D006442:Glycated Hemoglobin; D006801:Humans; D007328:Insulin; D008297:Male; D008875:Middle Aged; D009765:... | Endocrine journal | 2,012 | D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin A; D007328:Insulin; C517652:hemoglobin A1c protein, human; D005749:Gastric Inhibitory Polypeptide |
Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity. | The visual appearance of humans is derived significantly from our skin and hair color. While melanin from epidermal melanocytes protects our skin from the damaging effects of ultraviolet radiation, the biological value of pigmentation in the hair follicle, particularly on the scalp, is less clear. In this study, we exp... | 10.3390/ijms241612809 | 37,628,992 | D006801:Humans; D018859:Hair Follicle; D008543:Melanins; D012535:Scalp; D014466:Ultraviolet Rays; D006197:Hair; D008544:Melanocytes | International journal of molecular sciences | 2,023 | D008543:Melanins |
Formation and infrared spectroscopic characterization of three oxygen-rich BiO4 isomers in solid argon. | The reactions of bismuth atoms and O2 have been investigated using matrix isolation infrared spectroscopy and density functional theory calculations. The ground state bismuth atoms react with dioxygen to form the BiOO and Bi(O2)2 complexes spontaneously on annealing. The BiOO molecule is characterized to be an end-on b... | 10.1021/jp406126c | 24,112,025 | D001128:Argon; D001729:Bismuth; D007536:Isomerism; D010100:Oxygen; D014466:Ultraviolet Rays | The journal of physical chemistry. A | 2,013 | D001128:Argon; C033301:bismuth oxide; D010100:Oxygen; D001729:Bismuth |
ECONOMIC ANALYSIS OF TREATMENT OF THE PATIENTS WITH CHRONIC POSTTRAUMATIC OSTEOMYELITIS OF THE SHOULDER BY THE METHOD OF TRANSOSSEOUS OSTEOSYNTHESIS BY ILIZAROV’S APPARATUS. | An analysis of the terms of hospitalization, cost of treatment was made. There were matched the real medical costs of treatment of the patients with chronic posttraumatic osteomyelitis of the shoulder using the method of transosseous osteosynthesis with application of Ilizarov’s apparatus and medical costs according to... | 30,444,103 | D005593:Fracture Fixation, Internal; D017048:Health Care Costs; D006301:Health Services Needs and Demand; D006801:Humans; D010019:Osteomyelitis; D010346:Patient Care Management; D012426:Russia; D000070599:Shoulder Injuries | Vestnik khirurgii imeni I. I. Grekova | 2,016 | ||
Circ_0000463 contributes to the progression and glutamine metabolism of non-small-cell lung cancer by targeting miR-924/SLC1A5 signaling. | BACKGROUND
Circular RNAs (circRNAs) have shown pivotal regulatory roles in the pathology of non-small cell lung cancer (NSCLC). However, the role of circ_0000463 in NSCLC progression and its associated molecular mechanism remain to be illustrated.
METHODS
Cell proliferation ability was analyzed by colony formation as... | 10.1002/jcla.24116 | 34,811,815 | D026962:Amino Acid Transport System ASC; D000818:Animals; D017209:Apoptosis; D002289:Carcinoma, Non-Small-Cell Lung; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005973:Glutamine; D006801:Humans; D008168:Lung; D008175:Lung Neoplasms; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB... | Journal of clinical laboratory analysis | 2,022 | D026962:Amino Acid Transport System ASC; C000632963:MIRN924 microRNA, human; D035683:MicroRNAs; D015778:Minor Histocompatibility Antigens; D000079962:RNA, Circular; C420506:SLC1A5 protein, human; D005973:Glutamine |
Enhanced organic removal for shale gas fracturing flowback water by electrocoagulation and simultaneous electro-peroxone process. | Colloids and organics in shale gas fracturing flowback water (SGFFW) during shale gas extraction are of primary concerns. Coagulation combined with oxidation might be a promising process for SGFFW treatment. In this study, a novel electrocoagulation-peroxone (ECP) process was developed for SGFFW treatment by simultaneo... | 10.1016/j.chemosphere.2018.11.055 | 30,471,506 | D002244:Carbon; D055664:Electrochemical Techniques; D004564:Electrocoagulation; D004566:Electrodes; D000067071:Hydraulic Fracking; D017665:Hydroxyl Radical; D007700:Kinetics; D059206:Natural Gas; D009930:Organic Chemicals; D010084:Oxidation-Reduction; D010126:Ozone; D013464:Sulfuric Acids; D014874:Water Pollutants, Che... | Chemosphere | 2,019 | D059206:Natural Gas; D009930:Organic Chemicals; D013464:Sulfuric Acids; D014874:Water Pollutants, Chemical; D017665:Hydroxyl Radical; D010126:Ozone; D002244:Carbon; C048813:potassium peroxymonosulfuric acid |
Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition. | Small latent TGF-beta consists of latency associated peptide (LAP) bound to the 25 kDa TGF-beta by noncovalent interactions. Small latent TGF-beta is secreted from cells and deposited into the extracellular matrix as covalent complexes with its binding proteins, LTBPs. Four LTBPs have been molecularly cloned and their ... | 10.1242/jcs.114.15.2869 | 11,683,420 | D048868:Adaptor Proteins, Signal Transducing; D017398:Alternative Splicing; D002352:Carrier Proteins; D002461:Cell Line, Transformed; D017077:Culture Media, Conditioned; D003545:Cysteine; D018076:DNA, Complementary; D005347:Fibroblasts; D015870:Gene Expression; D006801:Humans; D015151:Immunoblotting; D007668:Kidney; D0... | Journal of cell science | 2,001 | D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D017077:Culture Media, Conditioned; D018076:DNA, Complementary; C509032:LTBP1 protein, human; C509035:LTBP2 protein, human; C509040:LTBP4 protein, human; D053779:Latent TGF-beta Binding Proteins; D012333:RNA, Messenger; D016212:Transforming Growth ... |
Eruptive and functional changes in periodontal ligament fibroblast orientation in CD44 wild-type vs. knockout mice. | BACKGROUND AND OBJECTIVE
Periodontal ligament (PDL) fibroblasts establish principal fibers of the ligament during tooth eruption, and maintain these fibers during occlusion. PDL development and occlusal adaptation includes changes in the orientation of PDL fibroblasts; however, the mechanism for these changes in orient... | 10.1111/jre.12113 | 23,808,836 | D000539:Alveolar Process; D000818:Animals; D021982:Cell-Matrix Junctions; D011508:Chondroitin Sulfate Proteoglycans; D003766:Dental Occlusion; D005109:Extracellular Matrix; D005347:Fibroblasts; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008963:Molar; D010513:Periodontal Ligament; D011956:Recepto... | Journal of periodontal research | 2,014 | D011508:Chondroitin Sulfate Proteoglycans; D011956:Receptors, Cell Surface |
Molecular iodine-catalyzed facile procedure for N-Boc protection of amines. | An efficient and practical protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of a catalytic amount of molecular iodine (10 mol %) under solvent-free conditions at ambient temperature is presented. | 10.1021/jo0612473 | 17,025,327 | The Journal of organic chemistry | 2,006 | ||
Ultrasonographic findings and the clinical results of treatment for lymphedema. | We undertook this study using ultrasonography to examine structural changes occurring in the subcutaneous tissue with lymphedema. Ultrasonographic images were taken in 178 outpatients and 29 inpatients, with the images of the subcutis fluid accumulation, which was categorized into three types ( grade 0: absent, grade 1... | 10.3400/avd.oa.14-00104 | 25,593,621 | Annals of vascular diseases | 2,014 | ||
Matched Cohort Comparison Indicates Superiority of Precurved Electrode Arrays. | OBJECTIVE
Characterize differences in adult cochlear implant outcomes and programming parameters for a straight (CI422/522) and a precurved (CI532) electrode array.
SETTING
Cochlear implant (CI) program at a tertiary otologic center.
PATIENTS
Fifty-eight adults were included in the study; 29 were implanted with CI4... | 10.1097/MAO.0000000000002366 | 31,469,799 | D000328:Adult; D019929:Cochlear Implantation; D003054:Cochlear Implants; D015331:Cohort Studies; D005260:Female; D006319:Hearing Loss, Sensorineural; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D013067:Speech Perception; D016896:Treatment Outcome | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology | 2,019 | |
Potassium 2-[(2-carboxy-phen-yl)disulfan-yl]benzoate-2,2'-disulfanediyl-dibenzoic acid (1/1). | In the title compound, K(+)·C(14)H(9)O(4)S(2) (-)·C(14)H(10)O(4)S(2), the hydrogen 2,2'-dithio-dibenzoate and 2,2'-disulfane-diyl-di-ben-zoic acid species combine to provide an O(6)S(2) donor set to the potassium cation based on a cubic geometry. K⋯S [3.1733 (7) and 3.5499 (8) Å] and K⋯O [2.6586 (16)-3.0661 (15) Å)] in... | 10.1107/S1600536809049824 | 21,578,911 | Acta crystallographica. Section E, Structure reports online | 2,009 | ||
Composition and decomposition of rhizoma peanut (Arachis glabrata Benth.) belowground biomass. | Roots and rhizomes can play an important role in nutrient cycling, however, few studies have investigated how their decomposition pattern is affected by defoliation and time of the year. This 2-year study evaluated root-rhizome composition and decomposition of a warm-season rhizomatous perennial legume [rhizoma peanut ... | 10.1038/s41598-022-14001-7 | 35,705,653 | D010367:Arachis; D018533:Biomass; D002244:Carbon; D003902:Detergents; D007887:Fabaceae | Scientific reports | 2,022 | D003902:Detergents; D002244:Carbon |
Corticosteroid Treatment Influences TA-Proteinuria and Renal Survival in IgA Nephropathy. | The clinical course of IgA nephropathy (IgAN) and its outcome are extremely variable. Proteinuria at baseline has been considered one of the most important risk factors. More recently, mean proteinuria of follow-up (time-average proteinuria: TAp) was described as a stronger marker of renal survival, suggesting to consi... | 10.1371/journal.pone.0158584 | 27,416,024 | D000293:Adolescent; D000305:Adrenal Cortex Hormones; D000328:Adult; D000368:Aged; D001379:Azathioprine; D003404:Creatinine; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA; D006801:Humans; D007668:Kidney; D007677:Kidney Function Tests; D008297:Male; D008875:... | PloS one | 2,016 | D000305:Adrenal Cortex Hormones; D003404:Creatinine; D001379:Azathioprine |
Fenofibrate reduces tumor necrosis factor-alpha serum concentration and adipocyte secretion of hypercholesterolemic rabbits. | BACKGROUND
Tumor necrosis factor-alpha (TNF-alpha) is produced by cells of the macrophage-monocyte lineage and by adipocytes. It may provide the link between inflammation and atherosclerosis. The aim of this study was to evaluate the effect of fenofibrate on serum TNF-alpha concentration and TNF-alpha secretion by adip... | 10.1016/j.cccn.2004.04.001 | 15,313,152 | D017667:Adipocytes; D000818:Animals; D001835:Body Weight; D002478:Cells, Cultured; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D011345:Fenofibrate; D006937:Hypercholesterolemia; D000960:Hypolipidemic Agents; D008055:Lipids; D008297:Male; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha | Clinica chimica acta; international journal of clinical chemistry | 2,004 | D000960:Hypolipidemic Agents; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D011345:Fenofibrate |
Gemcitabine-loaded microbubble system for ultrasound imaging and therapy. | Ultrasound imaging presents many positive attributes, including safety, real-time imaging, universal accessibility, and cost. However, inherent difficulties in discrimination between soft tissues and tumors prompted development of stabilized microbubble contrast agents. This presents the opportunity to develop agents i... | 10.1016/j.actbio.2021.05.046 | 34,082,100 | D000818:Animals; D045744:Cell Line, Tumor; D003841:Deoxycytidine; D051379:Mice; D045423:Microbubbles; D010190:Pancreatic Neoplasms; D014463:Ultrasonography; D000093542:Gemcitabine | Acta biomaterialia | 2,021 | D003841:Deoxycytidine; D000093542:Gemcitabine |
Psychological Distress of Healthcare Workers in Québec (Canada) During the Second and the Third Pandemic Waves. | OBJECTIVE
We aimed to measure the prevalence of psychological distress among Quebec healthcare workers (HCWs) during the second and third pandemic waves and to assess the effect of psychosocial risk factors (PSRs) on work-related psychological distress among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ... | 10.1097/JOM.0000000000002487 | 35,051,960 | D000086382:COVID-19; D006282:Health Personnel; D006801:Humans; D058873:Pandemics; D000079225:Psychological Distress; D011792:Quebec; D000086402:SARS-CoV-2 | Journal of occupational and environmental medicine | 2,022 | |
Posttranslational modifications as therapeutic targets for intestinal disorders. | A variety of biological processes are regulated by posttranslational modifications. Posttranslational modifications including phosphorylation, ubiquitination, glycosylation, and proteolytic cleavage, control diverse physiological functions in the gastrointestinal tract. Therefore, a better understanding of their implic... | 10.1016/j.phrs.2020.105412 | 33,412,276 | D000818:Animals; D005765:Gastrointestinal Agents; D006801:Humans; D007410:Intestinal Diseases; D011499:Protein Processing, Post-Translational | Pharmacological research | 2,021 | D005765:Gastrointestinal Agents |
Perceived learning needs of family physicians in british columbia. | To determine family physicians' preferences for time, location, instructional format, and topics, the Division of Continuing Medical Education at the University of British Columbia conducted a survey, in which 1200 questionnaires were mailed to a stratified, proportional random sample of the 3270 general practitioners ... | 21,234,037 | Canadian family physician Medecin de famille canadien | 1,990 | |||
Prospects for advancing tuberculosis control efforts through novel therapies. | BACKGROUND
Development of new, effective, and affordable tuberculosis (TB) therapies has been identified as a critical priority for global TB control. As new candidates emerge from the global TB drug pipeline, the potential impacts of novel, shorter regimens on TB incidence and mortality have not yet been examined.
M... | 10.1371/journal.pmed.0030273 | 16,866,578 | D000995:Antitubercular Agents; D001210:Asia, Southeastern; D003140:Communicable Disease Control; D023801:Directly Observed Therapy; D004334:Drug Administration Schedule; D015195:Drug Design; D006801:Humans; D015994:Incidence; D008962:Models, Theoretical; D010349:Patient Compliance; D055502:Secondary Prevention; D014376... | PLoS medicine | 2,006 | D000995:Antitubercular Agents |
Evaluation of hepatitis B reactivation among 62,920 veterans treated with oral hepatitis C antivirals. | Reactivation of hepatitis B virus (HBV) has been reported in hepatitis C virus-infected individuals receiving direct-acting antiviral (DAA) therapy. The overall risk among patients with current or prior HBV infection in the context of DAA treatment is unknown. The aim of this evaluation was to identify and characterize... | 10.1002/hep.29135 | 28,240,789 | D000284:Administration, Oral; D000328:Adult; D000998:Antiviral Agents; D015331:Cohort Studies; D060085:Coinfection; D005260:Female; D005500:Follow-Up Studies; D016174:Hepacivirus; D006509:Hepatitis B; D006514:Hepatitis B Surface Antigens; D006515:Hepatitis B virus; D006526:Hepatitis C; D006801:Humans; D015994:Incidence... | Hepatology (Baltimore, Md.) | 2,017 | D000998:Antiviral Agents; D006514:Hepatitis B Surface Antigens |
Structure and properties of thermoplastic polyurethanes based on poly(dimethylsiloxane): assessment of biocompatibility. | Properties and biocompatibility of a series of thermoplastic poly(urethane-siloxane)s (TPUSs) based on α,ω-dihydroxy ethoxy propyl poly(dimethylsiloxane) (PDMS) for potential biomedical application were studied. Thin films of TPUSs with a different PDMS soft segment content were characterized by (1) H NMR, quantitative... | 10.1002/jbm.a.35071 | 24,376,027 | D000327:Adsorption; D002448:Cell Adhesion; D002460:Cell Line; D004129:Dimethylpolysiloxanes; D042783:Endothelial Cells; D005340:Fibrinogen; D006801:Humans; D007770:L-Lactate Dehydrogenase; D008422:Materials Testing; D008567:Membranes, Artificial; D011140:Polyurethanes; D012710:Serum Albumin, Bovine; D013329:Structure-A... | Journal of biomedical materials research. Part A | 2,014 | D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D011140:Polyurethanes; D012710:Serum Albumin, Bovine; C013830:baysilon; D005340:Fibrinogen; D007770:L-Lactate Dehydrogenase |
[Anti-collagen antibodies. Their detection in rheumatoid polyarthritis, chronic atrophic polychondritis and various chronic inflammatory rheumatism]. | The authors administered by passive haemagglutination, natural or denatured type I and II anticollagen antibodies in the serum of 83 rheumatoid polyarthritis, 20 ankylosing spondylarthritis, 30 relapsing polychondritis, 13 diffuse sclerodermics, 12 Gougerot-Sjögren syndrome patients. Type II natural anti-collagen antib... | 6,612,199 | D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid; D001323:Autoantibodies; D003094:Collagen; D006621:Hip Joint; D006801:Humans; D007719:Knee Joint; D008875:Middle Aged; D010003:Osteoarthritis; D011081:Polychondritis, Relapsing; D012595:Scleroderma, Systemic; D012859:Sjogren's Syndrome; D013167:Spondylitis, Ank... | Revue du rhumatisme et des maladies osteo-articulaires | 1,983 | D001323:Autoantibodies; D003094:Collagen | |
Rhinovirus-induced Rapidly Progressing Acute Respiratory Distress Syndrome in an Immunocompetent Host. | A previously healthy, 59-year-old female presented with respiratory distress and dry cough for one week. Outpatient radiographic findings were suspicious for basilar pneumonia. Empiric broad-spectrum antibiotics were started; however, she continued to deteriorate rapidly over the next 48 hours, with chest X-ray showing... | 10.7759/cureus.3997 | 30,989,006 | Cureus | 2,019 | ||
Matrix Metalloproteinase-7 and Osteopontin Serum Levels as Biomarkers for Biliary Atresia. | OBJECTIVES
Matrix metallopeptidase-7 (MMP-7) and osteopontin (OPN) are important components in the pathophysiology of fibrosis in biliary atresia (BA). There has been much recent interest in MMP-7 serum level in the diagnosis of BA. We aimed to assess the diagnostic accuracy and prognostic value of both MMP-7 and OPN i... | 10.1097/MPG.0000000000003792 | 37,326,848 | D007223:Infant; D006801:Humans; D001656:Biliary Atresia; D053495:Osteopontin; D020783:Matrix Metalloproteinase 7; D011446:Prospective Studies; D015415:Biomarkers | Journal of pediatric gastroenterology and nutrition | 2,023 | D053495:Osteopontin; D020783:Matrix Metalloproteinase 7; D015415:Biomarkers |
Production, purification and characterization of recombinant yeast processing alpha 1,2-mannosidase. | The Saccharomyces cerevisiae processing alpha 1,2-mannosidase, which trims Man9GlcNAc to Man8GlcNAc, has a lumenally oriented catalytic domain and an N-terminal transmembrane domain. To obtain sufficient protein to study the structure and mechanism of action of this enzyme, the sequence encoding the catalytic domain wa... | 10.1093/glycob/4.5.697 | 7,881,184 | D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004271:DNA, Fungal; D006026:Glycoside Hydrolases; D008361:Mannosidases; D008969:Molecular Sequence Data; D051381:Rats; D011994:Recombinant Proteins; D012441:Saccharomyces cerevisiae | Glycobiology | 1,994 | D004271:DNA, Fungal; D011994:Recombinant Proteins; D006026:Glycoside Hydrolases; D008361:Mannosidases; C046090:mannosyl-oligosaccharide 1,2-alpha-mannosidase |
Effect of cloned inhibitor-resistant TEM beta-lactamases on the susceptibility of Haemophilus influenzae to amoxicillin/clavulanate. | OBJECTIVES
To determine the effect of cloned inhibitor-resistant TEM beta-lactamases (IRTs) on the susceptibility of Haemophilus influenzae to amoxicillin/clavulanate.
METHODS
IRT-2, -4 and -5 genes with various promoters were cloned into control strains of H. influenzae and the amoxicillin/clavulanate MICs were meas... | 10.1093/jac/dkm311 | 17,827,143 | D019980:Amoxicillin-Potassium Clavulanate Combination; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003001:Cloning, Molecular; D024901:Drug Resistance, Multiple, Bacterial; D006193:Haemophilus influenzae; D008826:Microbial Sensitivity Tests; D009154:Mutation; D011401:Promoter Regions, Genetic; D065093:be... | The Journal of antimicrobial chemotherapy | 2,007 | D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D065093:beta-Lactamase Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination; D001618:beta-Lactamases |
Influence of nutrition on the crimping rate of wool and the type and proportion of constituent proteins. | When the nutritional level of sheep is restricted, the staple crimp frequency of the resultant fleece increases substantially whereas the cystine and high-sulphur protein contents decrease. This is in marked contrast to the direct relationship between crimp frequency and cystine content among sheep. These observations ... | 10.1071/bi9750389 | 1,191,129 | D000596:Amino Acids; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D003553:Cystine; D005260:Female; D005998:Glycine; D011506:Proteins; D012756:Sheep; D013455:Sulfur; D014443:Tyrosine; D014935:Wool | Australian journal of biological sciences | 1,975 | D000596:Amino Acids; D011506:Proteins; D014443:Tyrosine; D003553:Cystine; D013455:Sulfur; D005998:Glycine |
New approaches in safe handling of hazardous drugs. | This session provided an overview of the health effects of occupational exposure to hazardous drugs and provided information about specific steps that can be taken to reduce accidental exposure, such as reducing surface contamination, use of personal protective equipment, and proper disposal guidelines, among other saf... | 15,478,576 | D000970:Antineoplastic Agents; D004348:Drug Labeling; D004784:Environmental Monitoring; D017408:Guidelines as Topic; D015386:Hazardous Substances; D006801:Humans; D017744:Medical Waste Disposal; D016273:Occupational Exposure; D016272:Occupational Health; D009859:Oncology Nursing; D011481:Protective Clothing; D017751:Sa... | ONS news | 2,004 | D000970:Antineoplastic Agents; D015386:Hazardous Substances; D017744:Medical Waste Disposal | |
Palladium-catalyzed addition of alcohol pronucleophiles to alkylidenecyclopropanes. | Palladium-catalyzed addition of alcohol pronucleophiles 1 to alkylidenecyclopropane derivatives 2 afforded the corresponding allylic ethers 3 in excellent to moderate yields. Catalyst optimization indicated the Pd(PPh3)4-P(o-tolyl)3 combination as the best system among all catalysts tested. Intramolecular reaction also... | 10.1021/jo001428j | 11,429,910 | The Journal of organic chemistry | 2,001 | ||
Banning shisha smoking in public places in Iran: an advocacy coalition framework perspective on policy process and change. | INTRODUCTION
Shisha smoking is a widespread custom in Iran with a rapidly growing prevalence especially among the youth. In this article, we analyze the policy process of enforcing a federal/state ban on shisha smoking in all public places in Kerman Province, Iran. Guided by the Advocacy Coalition Framework (ACF), we i... | 10.1093/heapol/czx015 | 28,369,366 | D003254:Consumer Advocacy; D006291:Health Policy; D007492:Iran; D011050:Policy Making; D036301:Qualitative Research; D012907:Smoking; D000074606:Smoking Prevention; D000075387:Smoking Water Pipes | Health policy and planning | 2,017 | |
The anti-tumor effect is enhanced by simultaneously targeting VEGF and PROK1 in colorectal cancer. | Hematogenous metastasis, mainly hepatic metastasis, is a frequent metastatic mode in colorectal cancer involving angiogenic growth factors. Two angiogenic growth factors, in particular, Vascular endothelial growth factor (VEGF) and Prokineticin1(PROK1), are considered to have an important role in hematogenous metastasi... | 10.18632/oncotarget.3474 | 25,788,276 | D000818:Animals; D000906:Antibodies; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms; D005260:Female; D005768:Gastrointestinal Hormones; D045325:HCT116 Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D058990:Molecular Targeted Therapy; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D042461:Vascu... | Oncotarget | 2,015 | D000906:Antibodies; D005768:Gastrointestinal Hormones; C467610:PROK1 protein, human; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived |
Feedback and tunneling operations of a p +-i-n + silicon nanowire field-effect transistor. | In this paper, we describe the feedback and tunneling operations of a dual top gate field-effect transistor (FET) with a p +-i-n + doped silicon nanowire channel. The transistor functions selectively in either a feedback FET (FBFET) or a tunneling FET mode by modulating the source-to-drain voltage, and it features an o... | 10.1088/1361-6528/aad9df | 30,102,245 | Nanotechnology | 2,018 | ||
Cost-effectiveness of Inpatient Tympanostomy Prophylaxis. | OBJECTIVE
Tympanostomy is the most common pediatric ambulatory surgery. Post-tympanostomy otorrhea is a prevalent complication leading to high costs to patients for treatment. The cost-effectiveness of intraoperative prophylaxis for both patient and institution has not been examined.
STUDY DESIGN
An analytical observ... | 10.1097/MAO.0000000000003330 | 34,420,019 | D000287:Administration, Topical; D002648:Child; D002939:Ciprofloxacin; D003362:Cost-Benefit Analysis; D006801:Humans; D007297:Inpatients; D008876:Middle Ear Ventilation; D015242:Ofloxacin | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology | 2,021 | D002939:Ciprofloxacin; D015242:Ofloxacin |
NMR-Based Metabolomics to Analyze the Effects of a Series of Monoamine Oxidases-B Inhibitors on U251 Cells. | Alzheimer's disease (AD) is a typical progressive neurodegenerative disorder, and with multiple possible pathogenesis. Among them, coumarin derivatives could be used as potential drugs as monoamine oxidase-B (MAO-B) inhibitors. Our lab has designed and synthesized coumarin derivatives based on MAO-B. In this study, we ... | 10.3390/biom13040600 | 37,189,348 | D009682:Magnetic Resonance Spectroscopy; D008279:Magnetic Resonance Imaging; D055432:Metabolomics; D055442:Metabolome; D010088:Oxidoreductases | Biomolecules | 2,023 | D010088:Oxidoreductases |
Optimal load for increasing muscle power during explosive resistance training in older adults. | BACKGROUND
Muscle power (force x velocity) recedes at a faster rate than strength with age and may also be a stronger predictor of fall risk and functional decline. The optimal training paradigm for improving muscle power in older adults is not known, although some literature suggests high velocity, low load training i... | 10.1093/gerona/60.5.638 | 15,972,618 | D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D015444:Exercise; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018482:Muscle, Skeletal; D010806:Physical Education and Training; D010807:Physical Endurance; D011336:Probability; ... | The journals of gerontology. Series A, Biological sciences and medical sciences | 2,005 | |
A Rare Case of Flavocoxid-Induced Pulmonary Fibrosis. | Pulmonary fibrosis is a chronic progressive interstitial lung disease characterized by repetitive cycles of epithelial cell injury and dysregulated repair. Although most cases of pulmonary fibrosis are idiopathic, a detailed history that includes medications, comorbidities, tobacco use, environmental exposures, and fam... | 10.7759/cureus.9617 | 32,923,218 | Cureus | 2,020 | ||
CNTF and GDNF, but not NT-4, support corticospinal motor neuron growth via direct mechanisms. | Axotomy and neurodegenerative diseases cause corticospinal motor neuron (CSMN) degeneration. We previously showed that CNTF, NT-4 and GDNF can support CSMN survival in enriched preparations. Here we developed a fluorescence-activated cell sorting method to highly purify CSMN (97+/-4.6%). We tested the neurotrophic acti... | 10.1097/00001756-199811160-00033 | 9,858,391 | D000818:Animals; D002469:Cell Separation; D002470:Cell Survival; D002478:Cells, Cultured; D020934:Ciliary Neurotrophic Factor; D005434:Flow Cytometry; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009046:Motor Neurons; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011712:Pyramidal Tracts; D05138... | Neuroreport | 1,998 | D020934:Ciliary Neurotrophic Factor; C495041:Gdnf protein, rat; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; C073922:neurotrophin 4 |
Human CCR6 + Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity. | Th17 cells have been investigated in mice primarily for their contributions to autoimmune diseases. However, the pathways of differentiation of Th17 and related (type 17) cells and the structure of the type 17 memory population in humans are not well understood; such understanding is critical for manipulating these cel... | 10.1101/2023.01.05.522630 | 36,789,418 | bioRxiv : the preprint server for biology | 2,023 | ||
Photosynthesis down-regulation precedes carbohydrate accumulation under sink limitation in Citrus. | Photosynthesis down-regulation due to an imbalance between sources and sinks in Citrus leaves could be mediated by excessive accumulation of carbohydrates. However, there is limited understanding of the physiological role of soluble and insoluble carbohydrates in photosynthesis regulation and the elements triggering th... | 10.1093/treephys/tpq103 | 21,367,744 | D001692:Biological Transport; D050260:Carbohydrate Metabolism; D032084:Citrus sinensis; D015536:Down-Regulation; D005638:Fruit; D010788:Photosynthesis; D018515:Plant Leaves; D013213:Starch | Tree physiology | 2,011 | D013213:Starch |
Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor. | Black cohosh is a commonly used botanical dietary supplement for the treatment of climacteric complaints. Because the opiate system in the brain is intimately associated with mood, temperature, and sex hormonal levels, the activity of black cohosh extracts at the human mu opiate receptor (hMOR) expressed in Chinese ham... | 10.1021/jf062808u | 17,177,511 | D000818:Animals; D001667:Binding, Competitive; D016466:CHO Cells; D031885:Cimicifuga; D006224:Cricetinae; D003412:Cricetulus; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D006801:Humans; D010936:Plant Extracts; D017450:Receptors, Opioid, mu; D014316:Tritium | Journal of agricultural and food chemistry | 2,006 | D010936:Plant Extracts; D017450:Receptors, Opioid, mu; D014316:Tritium; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- |
Preoperative assessment and treatment of appendiceal mucocele complicated by acute torsion: a case report. | BACKGROUND
Mucus-producing tumours of the appendix or mucoceles can, if left untreated, lead to dissemination of its contents into the peritoneal cavity causing substantial morbidity to the patient. Symptoms for complicated mucoceles can mimic those of acute appendicitis and the final diagnosis is most likely made intr... | 10.1186/1756-0500-7-1 | 24,382,056 | D000006:Abdomen, Acute; D000328:Adult; D001062:Appendectomy; D001065:Appendix; D002429:Cecal Diseases; D004630:Emergencies; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008279:Magnetic Resonance Imaging; D009078:Mucocele; D009336:Necrosis; D011300:Preoperative Care; D014102:Torsion Abnormality; D014463:Ultraso... | BMC research notes | 2,014 | |
Computed tomography and magnetic resonance imaging of the nasopharynx. | Various radiological techniques are used for the evaluation of nasopharyngeal lesions--conventional lateral and base projections, computed tomography (CT), magnetic resonance imaging (MRI), and angiography. Owing to its multiplanar imaging capability, MRI is the optimal modality for investigation of the anatomy and dem... | 1,317,366 | D002294:Carcinoma, Squamous Cell; D003560:Cysts; D018219:Histiocytoma, Benign Fibrous; D006801:Humans; D008279:Magnetic Resonance Imaging; D009302:Nasopharyngeal Diseases; D009303:Nasopharyngeal Neoplasms; D009305:Nasopharynx; D014057:Tomography, X-Ray Computed | Israel journal of medical sciences | 1,992 | ||
Laser-induced bubble generation on a gold nanoparticle: A nonsymmetrical description. | The modeling of bubbles initiated by laser-irradiated nanoparticles is of interest for many applications. There is at present no comprehensive physical picture for all the stages of the process. We present an alternative approach with a key assumption: the vapor bubble evolves adjacent to the nanoparticle. To take into... | 10.1103/PhysRevE.92.062301 | 26,764,686 | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,015 | ||
Effect of treatment of chronic theileriosis with buparvaquone on milk yields. | Chronic, undulating Theileria annulata infection was diagnosed as the cause of severely depressed milk yields in a herd of 44 Friesian cows in Egypt. The herd was divided at random into two groups of 22; one group was injected intramuscularly with a single dose of the experimental antitheilerial drug, buparvaquone, whi... | 10.1007/BF02261091 | 2,617,675 | D000818:Animals; D000981:Antiprotozoal Agents; D001831:Body Temperature; D002417:Cattle; D005260:Female; D007774:Lactation; D009285:Naphthoquinones; D011247:Pregnancy; D011897:Random Allocation; D013801:Theileriasis | Tropical animal health and production | 1,989 | D000981:Antiprotozoal Agents; D009285:Naphthoquinones; C046326:buparvaquone |
Changes in eggshell conductance, water loss and hatchability of layer hens with flock age and moulting. | 1. Changes in water loss, eggshell conductance and hatchability with flock age were monitored in layer hens in a commercial hatchery. 2. Optimal water loss for maximal hatchability of layer eggs was found to be 12 to 13% of initial egg mass at d 18 of incubation. 3. Mass specific water vapour conductance (GH(2)Osp) inc... | 10.1080/00071660802495288 | 19,093,240 | D000818:Animals; D002645:Chickens; D004528:Egg Shell; D006813:Humidity; D007185:Incubators; D018978:Molting; D010063:Ovum; D013696:Temperature; D013997:Time Factors; D014867:Water | British poultry science | 2,008 | D014867:Water |
Reforming referral procedures. | Sam Foster, Chief Nurse at Heart of England NHS Foundation Trust, considers how fitness to practise referrals could be streamlined to increase efficiency and reduce delays in decisions being made. | 10.12968/bjon.2016.25.21.1223 | 27,882,797 | D004647:Employee Discipline; D004648:Employee Grievances; D004739:England; D006801:Humans; D009726:Nurses; D009740:Nursing Staff; D010559:Personnel Management; D011363:Professional Impairment; D012017:Referral and Consultation; D013222:State Medicine; D035642:Whistleblowing | British journal of nursing (Mark Allen Publishing) | 2,016 | |
Determinants of chronic venous disease after acute deep venous thrombosis. | PURPOSE
The purpose of this investigation was to evaluate the relationship between the presenting features of an acute deep venous thrombosis (DVT), the subsequent natural history of the thrombus, and the ultimate outcome as defined according to the Society for Vascular Surgery and the North American Chapter of the Int... | 10.1016/s0741-5214(98)70057-6 | 9,808,849 | D000208:Acute Disease; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D014652:Vascular Diseases; D020246:Venous Thrombosis | Journal of vascular surgery | 1,998 | |
Glucose-mediated cytoprotection in the gut epithelium under ischemic and hypoxic stress. | Single-layered intestinal epithelia play key roles in the maintenance of gut homeostasis and barrier integrity. Various types of epithelial cell death, including apoptosis, necrosis, and necroptosis, have been detected in ischemic and hypoxic stress conditions, thus resulting in bacterial translocation and gut-derived ... | 10.14670/HH-11-839 | 27,824,216 | D000818:Animals; D019610:Cytoprotection; D005947:Glucose; D006801:Humans; D000860:Hypoxia; D007413:Intestinal Mucosa; D015427:Reperfusion Injury; D013312:Stress, Physiological | Histology and histopathology | 2,017 | D005947:Glucose |
Netrin UNC-6 and the regulation of branching and extension of motoneuron axons from the ventral nerve cord of Caenorhabditis elegans. | In the Caenorhabditis elegans embryo, some ventral midline motoneurons extend a process circumferentially to the dorsal midline and a process longitudinally along ventral nerve cord interneurons. Circumferential migrations are guided by netrin UNC-6, which repels motoneuron axons dorsally. Although the motoneuron cell ... | 10,436,059 | D000818:Animals; D030801:Animals, Genetically Modified; D001369:Axons; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins; D002478:Cells, Cultured; D017952:Ganglia, Invertebrate; D015801:Helminth Proteins; D009046:Motor Neurons; D009419:Nerve Tissue Proteins; D000075385:Netrins; D010641:Phenotype | The Journal of neuroscience : the official journal of the Society for Neuroscience | 1,999 | D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D009419:Nerve Tissue Proteins; D000075385:Netrins; C078146:UNC-6 protein, C elegans | |
Electrophoretic mobility shift assays to study protein binding to damaged DNA. | The electrophoretic mobility shift assay (EMSA) can be used to identify proteins that bind specifically to damaged DNA. EMSAs detect the presence of key DNA repair proteins, such as ultraviolet (UV)-damaged DNA binding protein, which is involved in nucleotide excision repair, and Ku and DNA-PKcs, which are involved in ... | 10.1385/1-59259-973-7:323 | 16,673,891 | D002457:Cell Extracts; D002478:Cells, Cultured; D002945:Cisplatin; D003432:Cross-Linking Reagents; D004247:DNA; D004249:DNA Damage; D004265:DNA Helicases; D015342:DNA Probes; D004268:DNA-Binding Proteins; D024202:Electrophoretic Mobility Shift Assay; D006801:Humans; D007553:Isotope Labeling; D000072200:Ku Autoantigen; ... | Methods in molecular biology (Clifton, N.J.) | 2,006 | D002457:Cell Extracts; D003432:Cross-Linking Reagents; C091435:DDB1 protein, human; D015342:DNA Probes; D004268:DNA-Binding Proteins; D011506:Proteins; D013462:Sulfur Radioisotopes; D004247:DNA; D004265:DNA Helicases; C106893:XRCC5 protein, human; D000072200:Ku Autoantigen; D002945:Cisplatin |
Inhibitory regulation of serum factor(s)-caused ornithine decarboxylase induction by the protein kinase C system in A431 human epidermoid carcinoma cells. | Replacement of the culture medium with fresh medium containing 10% fetal calf serum caused ornithine decarboxylase (ODC) induction in A431 human epidermoid carcinoma cells. Two peaks of ODC activity were observed at 5 and 14 hr after the medium replacement. The peak activity observed at 5 hr was more prominent than tha... | 10.1254/jjp.56.203 | 1,880,999 | D001769:Blood; D002294:Carcinoma, Squamous Cell; D015536:Down-Regulation; D004789:Enzyme Activation; D004790:Enzyme Induction; D006801:Humans; D066298:In Vitro Techniques; D009955:Ornithine Decarboxylase; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate; D014407:Tumor Cells, Cultured | Japanese journal of pharmacology | 1,991 | D011493:Protein Kinase C; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate |
[The practice guideline 'Hormonal contraception' (second revision) from the Dutch College of General Practitioners; a response from the perspective of obstetrics & gynaecology]. | The Dutch College of General Practitioners' (NHG) guideline on hormonal contraception does not follow the WHO criteria for the use of oral contraceptives in contrast to the guideline of the Dutch Society of Obstetrics and Gynaecology. Contrary to the WHO criteria, the NHG guideline considers a blood-pressure measuremen... | 15,279,208 | D003267:Contraception; D003278:Contraceptives, Oral, Hormonal; D005260:Female; D006176:Gynecology; D006801:Humans; D009426:Netherlands; D009774:Obstetrics; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D016896:Treatment Outcome; D014944:World Health Organization | Nederlands tijdschrift voor geneeskunde | 2,004 | D003278:Contraceptives, Oral, Hormonal | |
Sorafenib stimulates human skin type mast cell degranulation and maturation. | BACKGROUND
Sorafenib is a multi-kinase inhibitor for treating advanced hepatocellular and renal cell carcinomas by targeting various types of receptors and signaling molecules, including vascular endothelial growth factor receptors, platelet-derived growth factor receptor, and Raf-1. Sorafenib may cause diverse cutaneo... | 10.1016/j.jdermsci.2017.08.005 | 28,843,624 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000730:Androstadienes; D000970:Antineoplastic Agents; D017209:Apoptosis; D001706:Biopsy; D002452:Cell Count; D015550:Cell Degranulation; D049109:Cell Proliferation; D003875:Drug Eruptions; D048049:Extracellular Signal-Regulated MAP Kinases; D005260:Female; D00541... | Journal of dermatological science | 2,017 | D000730:Androstadienes; D000970:Antineoplastic Agents; D005419:Flavonoids; D010671:Phenylurea Compounds; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D019089:Stem Cell Factor; D042461:Vascular Endothelial Growth Factor A; D009536:Niacinamide; D000077157:Sorafenib; D048049:Extracel... |
Development of a selective photoactivatable antagonist for corticotropin-releasing factor receptor, type 2 (CRF2). | A novel photoactivatable analog of antisauvagine-30 (aSvg-30), a specific antagonist for corticotropin-releasing factor (CRF) receptor, type 2 (CRF2), has been synthesized and characterized. The N-terminal amino-acid d-Phe in aSvg-30 [d-Phe11,His12]Svg(11-40) was replaced by a phenyldiazirine, the 4-(1-azi-2,2,2-triflu... | 10.1046/j.1432-1033.2002.03246.x | 12,392,562 | D000595:Amino Acid Sequence; D029845:Amphibian Proteins; D000818:Animals; D001388:Aziridines; D001389:Azirines; D001565:Benzoates; D001667:Binding, Competitive; D002460:Cell Line; D002462:Cell Membrane; D003346:Corticotropin-Releasing Hormone; D000242:Cyclic AMP; D006801:Humans; D007457:Iodine Radioisotopes; D007668:Ki... | European journal of biochemistry | 2,002 | D029845:Amphibian Proteins; D001388:Aziridines; D001389:Azirines; D001565:Benzoates; C101531:CRF receptor type 2; D007457:Iodine Radioisotopes; D008024:Ligands; D010446:Peptide Fragments; D036361:Peptide Hormones; D010455:Peptides; D018019:Receptors, Corticotropin-Releasing Hormone; C116607:antisauvagine 30; C469233:sa... |
[Significance of histological signs of chronic HBV and HCV infections in the differential diagnosis of chronic hepatitis]. | 100 inpatients with chronic hepatitis, mainly with mild hepatitis, underwent serological, histological, and immunohistochemical studies for markers of HBV and HCV infections. The histological features of HBV and HCV infections coincided with serological and immunohistochemical findings. The histological and immunohisto... | 17,642,185 | D000911:Antibodies, Monoclonal; D003937:Diagnosis, Differential; D016174:Hepacivirus; D006514:Hepatitis B Surface Antigens; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic; D018936:Hepatitis C Antigens; D019698:Hepatitis C, Chronic; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver; D011237:Predictive... | Arkhiv patologii | 2,007 | D000911:Antibodies, Monoclonal; D006514:Hepatitis B Surface Antigens; D018936:Hepatitis C Antigens; C093542:NS4 protein, hepatitis C virus; D017361:Viral Nonstructural Proteins | |
Shorter sleep duration and longer sleep onset latency are related to difficulty disengaging attention from negative emotional images in individuals with elevated transdiagnostic repetitive negative thinking. | BACKGROUND AND OBJECTIVES
Repetitive negative thinking (RNT) is often associated with disruptions in sleep and circadian rhythms. Disruptions in sleep and circadian rhythms may deal a "second hit" to attentional control deficits. This study evaluated whether sleep and circadian rhythm disruptions are related to the top... | 10.1016/j.jbtep.2017.10.003 | 29,111,422 | D000328:Adult; D001288:Attention; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000067657:Pessimism; D000074222:Rumination, Cognitive; D012890:Sleep; D012893:Sleep Wake Disorders | Journal of behavior therapy and experimental psychiatry | 2,018 | |
Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway. | The filamentous fungus Aspergillus nidulans contains a cluster of 25 genes that encode enzymes required to synthesize a toxic and carcinogenic secondary metabolite called sterigmatocystin (ST), a precursor of the better known fungal toxin aflatoxin (AF). One ST Cluster (stc) gene, aflR, functions as a pathway-specific ... | 10.1093/emboj/16.16.4916 | 9,305,634 | D000348:Aflatoxins; D001230:Aspergillus; D001233:Aspergillus nidulans; D002855:Chromatography, Thin Layer; D005656:Fungal Proteins; D019204:GTP-Binding Proteins; D020690:GTPase-Activating Proteins; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D009154:Mutation; D011506:Proteins; D012333:RNA, Messen... | The EMBO journal | 1,997 | D000348:Aflatoxins; C102142:FADA protein, Emericella nidulans; C089966:FLUG protein, Emericella nidulans; D005656:Fungal Proteins; D020690:GTPase-Activating Proteins; D011506:Proteins; D012333:RNA, Messenger; C091553:flbA protein, Aspergillus nidulans; D013241:Sterigmatocystin; D019204:GTP-Binding Proteins |
Management of Intracranial Metastatic Disease With Laser Interstitial Thermal Therapy. | Treatment approaches for metastatic brain tumors continue to evolve, with increasing recent emphasis on focal therapies whenever possible. MRI-guided Laser Interstitial Thermal Therapy (LITT) is a minimally invasive surgical option that has broadened the capability of the neurosurgeon in treating difficult-to-treat int... | 10.3389/fonc.2018.00499 | 30,430,083 | Frontiers in oncology | 2,018 | ||
Add-on filgrastim during clozapine rechallenge unsuccessful in preventing agranulocytosis. | Granulocyte colony-stimulating factor agents such as filgrastim can be administered in order to reduce the duration of clozapine-induced agranulocytosis. Successful long-term combination treatment with filgrastim and clozapine in patients with previous clozapine-induced agranulocytosis has been described in several cas... | 23,395,419 | D000328:Adult; D000380:Agranulocytosis; D014150:Antipsychotic Agents; D003024:Clozapine; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor; D006801:Humans; D008297:Male; D011994:Recombinant Proteins; D012559:Schizophrenia | General hospital psychiatry | 2,013 | D014150:Antipsychotic Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D003024:Clozapine; D000069585:Filgrastim | |
Reliability of Short-Term Heart Rate Variability Indexes Assessed through Photoplethysmography. | The gold standard method to monitor heart rate variability (HRV) comprises measuring the time series of interbeat interval durations from electrocardiographic (ECG) recordings. However, due to the widespread use, simplicity and usability of photoplethysmographic (PPG) techniques, monitoring pulse rate variability (PRV)... | 10.1109/EMBC.2018.8513634 | 30,441,608 | D004562:Electrocardiography; D019277:Entropy; D006339:Heart Rate; D006801:Humans; D017156:Photoplethysmography; D015203:Reproducibility of Results | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference | 2,018 | |
Chameleonic appearance of caseous calcification of the mitral valve - still a problem for its appropriate management. | According to the research literature, the caseous calcification of the mitral annulus (CCMA) is a rare variant of the mitral annulus calcification (MAC) entity, described mostly in elderly women. The aim of this study was to present the case of a 53-year-old female patient with caseous calcification of the mitral valve... | 10.47162/RJME.61.2.25 | 33,544,807 | D000818:Animals; D005260:Female; D006349:Heart Valve Diseases; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve | Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie | 2,020 |
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