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Fucoidan Immobilized at the Surface of a Fibrous Mesh Presents Toxic Effects over Melanoma Cells, But Not over Noncancer Skin Cells. | The use of fucoidan, a marine-origin bioactive polymer, is herein proposed as a component of an innovative and effective strategy against melanoma, one of the most aggressive skin cancers. First, fucoidan antitumor activity, in its soluble form, was assessed presenting increased cytotoxicity over melanoma cells when co... | 10.1021/acs.biomac.0c00482 | 32,421,313 | D002470:Cell Survival; D006801:Humans; D008545:Melanoma; D057139:Nanofibers; D011134:Polysaccharides | Biomacromolecules | 2,020 | D011134:Polysaccharides; C007789:fucoidan |
Effect of a high-protein, very-low-calorie diet on resting metabolism, thyroid hormones, and energy expenditure of obese middle-aged women. | A 4-6 mo study was conducted to examine effects of a very-low-calorie, high-protein diet and realimentation on energy expenditure, resting metabolic rate (RMR), and serum thyroid hormones of obese women aged 30-54 yr. Fifteen healthy women, greater than or equal to 126% ideal body weight, were placed on the diet (420 k... | 10.1093/ajcn/45.2.391 | 3,812,338 | D000328:Adult; D001481:Basal Metabolism; D004038:Diet, Reducing; D004044:Dietary Proteins; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity; D013963:Thyroid Hormones | The American journal of clinical nutrition | 1,987 | D004044:Dietary Proteins; D013963:Thyroid Hormones |
VeCHArt: Visually Enhanced Comparison of Historic Art Using an Automated Line-Based Synchronization Technique. | The analysis of subtle deviations between different versions of historical prints has been a long-standing challenge in art history research. So far, this challenge has required extensive domain knowledge, fine-tuned expert perception, and time-consuming manual labor. In this paper we introduce an explorative visual ap... | 10.1109/TVCG.2019.2908166 | 30,946,669 | IEEE transactions on visualization and computer graphics | 2,020 | ||
Primary results of the Spanish Cryoballoon Ablation Registry: acute and long-term outcomes of the RECABA study. | Cryoablation is safe and effective for the treatment of atrial fibrillation (AF) in controlled clinical trials, but contemporary real-world usage and outcomes are limited. The Report of the Spanish Cryoballoon Ablation Registry (RECABA) was designed to evaluate acute and 12-month outcomes of cryoballoon ablation for th... | 10.1038/s41598-021-96655-3 | 34,446,764 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation; D003452:Cryosurgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D012008:Recurrence;... | Scientific reports | 2,021 | |
Purchasing health services abroad: practices of cross-border contracting and patient mobility in six European countries. | OBJECTIVES
Contracting health services outside the public, statutory health system entails purchasing capacity from domestic non-public providers or from providers abroad. Over the last decade, these practices have made their way into European health systems, brought about by performance-oriented reforms and EU princip... | 10.1016/j.healthpol.2009.11.016 | 20,031,249 | D001291:Attitude of Health Personnel; D001294:Attitude to Health; D001530:Belgium; D005060:Europe; D005062:European Union; D006291:Health Policy; D006302:Health Services Research; D006801:Humans; D009042:Motivation; D009313:National Health Programs; D020416:Outsourced Services; D018579:Patient Selection; D017149:Privat... | Health policy (Amsterdam, Netherlands) | 2,010 | |
The Evolving Role of 18F-FDG PET/CT in Diagnosis and Prognosis Prediction in Progressive Prostate Cancer. | Positron emission tomography/computed tomography (PET/CT) is widely used in prostate cancer to evaluate the localized tumor burden and detect symptomatic metastatic lesions early. 18F-FDG is the most used tracer for oncologic imaging, but it has limitations in detecting early-stage prostate cancer. 68Ga-PSMA is a new t... | 10.3389/fonc.2021.683793 | 34,395,251 | Frontiers in oncology | 2,021 | ||
Intellectual disability in young people in custody in New South Wales, Australia - prevalence and markers. | BACKGROUND
Intellectual disability (ID) is known to be more common in incarcerated groups, especially incarcerated youth. Aboriginal young people have higher rates of ID, and make up half of all youth in juvenile custody in New South Wales (NSW), Australia. We aimed to describe the prevalence of possible ID and borderl... | 10.1111/jir.12109 | 24,422,559 | D000293:Adolescent; D057237:Criminals; D005260:Female; D006801:Humans; D008607:Intellectual Disability; D007604:Juvenile Delinquency; D008297:Male; D044468:Native Hawaiian or Other Pacific Islander; D009517:New South Wales; D015995:Prevalence | Journal of intellectual disability research : JIDR | 2,014 | |
All-Dielectric Gratings with High-Quality Structural Colors. | We present a dual-layer hafnium dioxide (HfO2) grating capable of full-color modulation in the visible spectrum by leveraging the magnetic dipole resonance induced by the lower-layer HfO2 grating, while the upper-layer HfO2 grating serves as a refractive index matching layer to effectively suppress high-order Mie reson... | 10.3390/nano13172414 | 37,686,921 | Nanomaterials (Basel, Switzerland) | 2,023 | ||
Invasive and noninvasive assessment of cerebral oxygenation in patients with severe traumatic brain injury. | PURPOSE
The aim of this study is to investigate the relationship between invasive brain tissue oxygen pressure (PbrO(2)) and noninvasive regional transcranial oxygen saturation (rSO(2)) in 22 stable patients with severe traumatic brain injury (TBI) during a 16 h period.
METHODS
This was a prospective, observational s... | 10.1007/s00134-010-1920-7 | 20,502,869 | D000293:Adolescent; D000328:Adult; D001921:Brain; D020520:Brain Infarction; D001930:Brain Injuries; D002560:Cerebrovascular Circulation; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen; D010101:Oxygen Consumption; D011446:Prospective Studies; D014193:Trauma Centers; D015599:Trauma S... | Intensive care medicine | 2,010 | D010100:Oxygen |
Intraosseous pressure measurement during iliac bone marrow biopsy: its feasibility and difference of IOP in diseased marrow and non-diseased marrow. | OBJECTIVE
The purposes of this study were (1) to establish the feasibility and safety of an imaging-guided technique for intraosseous pressure (IOP) measurement in a large cohort of patients, and (2) to compare IOP values between normal and diseased bone marrow.
METHODS
Adult patients undergoing CT-guided marrow biop... | 10.1007/s00256-023-04431-3 | 37,635,152 | Skeletal radiology | 2,023 | ||
The association between arterial stiffness and cancer occurrence: Data from Kailuan cohort study. | Background
This study aimed to investigate whether increased arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV) is associated with cancer.
Materials and methods
A total of 45,627 Chinese adults underwent a baPWV examination. The participants were followed up from 1st January 2012 to 31st Decem... | 10.3389/fcvm.2023.1112047 | 36,937,940 | Frontiers in cardiovascular medicine | 2,023 | ||
Characterization of Non-Cholesterol Sterols in Microglia Cell Membranes Using Targeted Mass Spectrometry. | BACKGROUND
Non-cholesterol sterols, as well as plant sterols, cross the blood-brain barrier and, thus, can be incorporated into cell membranes, affecting the cell's inflammatory response. The aim of our work was to develop an analytical protocol for a quantitative assessment of the sterol composition within the membran... | 10.3390/cells12070974 | 37,048,046 | D013261:Sterols; D002853:Chromatography, Liquid; D017628:Microglia; D053719:Tandem Mass Spectrometry; D010840:Phytosterols; D013265:Stigmasterol; D007810:Lanosterol; D002462:Cell Membrane | Cells | 2,023 | D013261:Sterols; D010840:Phytosterols; D013265:Stigmasterol; D007810:Lanosterol |
Understanding sexual perpetration against children: effects of attachment style, interpersonal involvement, and hypersexuality. | This study explores in an adolescent sample hypotheses about child sexual abuse perpetration drawn from contemporary theories that implicate insecure attachment and adolescent social development. Specifically, three 13- to 18-year-old adolescent male samples (sex offenders with child victims, sex offenders with peer/ad... | 10.1177/1079063209353183 | 19,923,635 | D000293:Adolescent; D000294:Adolescent Behavior; D002648:Child; D002650:Child Abuse, Sexual; D003430:Cross-Sectional Studies; D006801:Humans; D007389:Internal-External Control; D007398:Interpersonal Relations; D007604:Juvenile Delinquency; D008297:Male; D009769:Object Attachment; D010379:Peer Group; D010552:Personality... | Sexual abuse : a journal of research and treatment | 2,010 | |
Correlation of chromatin composition with metabolic changes in nuclei of primitive erythroid cells from chicken embryos. | Changes in levels of biosynthesis of DNA, RNA, and histones were compared with relative proportions of each histone class during primitive erythropoiesis in embryonic chicks. We confirmed that erythrocyte-specific histone 5 (H5) was substantial in the earliest accessible, erythroblast-enriched stage and that it doubled... | 10.1139/o80-102 | 6,161,682 | D000818:Animals; D002467:Cell Nucleus; D002642:Chick Embryo; D002843:Chromatin; D004247:DNA; D004912:Erythrocytes; D004920:Erythropoiesis; D006657:Histones; D012313:RNA | Canadian journal of biochemistry | 1,980 | D002843:Chromatin; D006657:Histones; D012313:RNA; D004247:DNA |
Ocular rosacea. | Ocular rosacea was diagnosed in 6.3% of a cornea/external disease referral practice where more than half of the patients referred are for corneal surgery. The most common signs and symptoms are also common to many patients in the general practice of ophthalmology, i.e., foreign body sensation, burning, superficial punc... | 6,224,068 | D000328:Adult; D000368:Aged; D003229:Conjunctival Diseases; D003316:Corneal Diseases; D005141:Eyelid Diseases; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012393:Rosacea; D013752:Tetracycline; D013997:Time Factors | Metabolic, pediatric, and systemic ophthalmology | 1,982 | D013752:Tetracycline | |
Comparison of single-strand conformation polymorphism and heteroduplex analysis for detection of mutations in Charcot-Marie-Tooth type 1 disease and related peripheral neuropathies. | To compare the sensitivity of the mutation detection techniques single-strand conformation polymorphism analysis (SSCP) and heteroduplex analysis (HA), we analyzed a cohort of 73 patients with a diagnosis of a demyelinating neuropathy, but without the CMT1A duplication, for mutations in the coding region of the myelin ... | 10.1159/000472227 | 9,043,865 | D002607:Charcot-Marie-Tooth Disease; D015331:Cohort Studies; D017630:Connexins; D004252:DNA Mutational Analysis; D003711:Demyelinating Diseases; D005069:Evaluation Studies as Topic; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D018993:Myelin P0 Protein; D009185:Myelin Proteins; D009692:Nucleic Acid Hete... | European journal of human genetics : EJHG | 1,996 | D017630:Connexins; D018993:Myelin P0 Protein; D009185:Myelin Proteins; D009692:Nucleic Acid Heteroduplexes; C073687:PMP22 protein, human |
Strongly nonlinear long gravity waves in uniform shear flows. | Long surface gravity waves of finite amplitude in uniform shear flows are considered by using an asymptotic model derived under the assumption that the aspect ratio between wavelength and water depth is small. Since its derivation requires no assumption on wave amplitude, the model can be used to describe arbitrary amp... | 10.1103/PhysRevE.68.026305 | 14,525,103 | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,003 | ||
The Effect of Drug Abuse on Clinical Outcomes of Adult Burn Patients Admitted to a Burn Center in the North of Iran. | Objective
Burn trauma is a life-threatening incident that may be accompanied by several risk factors that increase morbidity and mortality. Drug abuse is one of the lifestyle dangers on the rise globally and can have an impact on the outcomes of burn injuries. This study aimed to evaluate the effect of drug abuse on th... | 10.30476/BEAT.2023.98282.1424 | 37,193,010 | Bulletin of emergency and trauma | 2,023 | ||
Evaluation of the enantiomers of 1-octen-3-ol and 1-octyn-3-ol as attractants for mosquitoes associated with a freshwater swamp in Florida, U.S.A. | Field studies were conducted at wooded wetlands in Gainesville, FL, U.S.A., to assess responses of natural populations of adult mosquitoes (Diptera: Culicidae) to American Biophysics MM-X and Coleman MD-2500 traps baited with enantiomers of 1-octen-3-ol, a naturally occurring compound, and 1-octyn-3-ol, a closely relat... | 10.1111/j.1365-2915.2007.00697.x | 18,092,970 | D000480:Alkynes; D000818:Animals; D009033:Culicidae; D005431:Florida; D005618:Fresh Water; D007536:Isomerism; D009032:Mosquito Control; D000442:Octanols; D010675:Pheromones; D013045:Species Specificity | Medical and veterinary entomology | 2,007 | D000480:Alkynes; D000442:Octanols; D010675:Pheromones; C010411:insect attractants; C042001:1-octyne; C038844:1-octen-3-ol |
Postpartum hemolytic uremic syndrome associated with antiphospholipid antibodies. A case report and review of the literature. | Postpartum hemolytic uremic syndrome (HUS) is described in a woman with a history of spontaneous abortions and both circulating lupus anticoagulant and anticardiolipin antibody (ACA). After termination of her pregnancy because of severe preeclampsia, ACA blood levels increased simultaneously with the onset of a microan... | 10.1159/000168432 | 1,492,877 | D000328:Adult; D017153:Antibodies, Anticardiolipin; D016736:Antiphospholipid Syndrome; D005260:Female; D006463:Hemolytic-Uremic Syndrome; D006801:Humans; D010951:Plasma Exchange; D011247:Pregnancy; D011644:Puerperal Disorders | American journal of nephrology | 1,992 | D017153:Antibodies, Anticardiolipin |
Tumor cell surface beta 1-4-linked galactose binds to lectin(s) on microvascular endothelial cells and contributes to organ colonization. | Cell surface carbohydrate structures acting as ligands for tissue specific mammalian lectins have been implicated in cell-cell interactions during embryogenesis, lymphocyte homing, and tumor cell metastasis. In this report, we provide evidence that beta 1-4 linked galactose (Gal) residues in N-linked oligosaccharides o... | 10.1083/jcb.111.2.773 | 2,116,422 | D000470:Alkaloids; D000818:Animals; D002417:Cattle; D002448:Cell Adhesion; D002460:Cell Line; D002462:Cell Membrane; D004730:Endothelium, Vascular; D005434:Flow Cytometry; D005690:Galactose; D006026:Glycoside Hydrolases; D007212:Indolizines; D007700:Kinetics; D037102:Lectins; D008228:Lymphoma, Non-Hodgkin; D051379:Mice... | The Journal of cell biology | 1,990 | D000470:Alkaloids; D007212:Indolizines; D037102:Lectins; D009844:Oligosaccharides; D006026:Glycoside Hydrolases; C037806:castanospermine; D017026:Swainsonine; D005690:Galactose |
Dreamlike mentations during sleepwalking and sleep terrors in adults. | BACKGROUND
Sleep terrors and sleepwalking are described as arousals from slow wave sleep with no or poor mental recollection.
OBJECTIVE
To characterize the mental content retrospectively associated with sleep terrors or sleepwalking.
SETTING
University Hospital.
DESIGN
Controlled prospective cohort.
PARTICIPANT... | 10.1093/sleep/32.12.1621 | 20,041,598 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000374:Aggression; D001519:Behavior; D002648:Child; D015331:Cohort Studies; D019548:Crime Victims; D004325:Dreams; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D020184:Night Terrors; D017286:Polysomnography; D01144... | Sleep | 2,009 | |
Synthesis and in vitro inhibition properties of oligonucleotide conjugates carrying amphipathic proline-rich peptide derivatives of the sweet arrow peptide (SAP). | In this study, a series of derivatives of the amphipathic proline-rich sweet arrow peptide (SAP) were covalently linked to antisense oligonucleotides designed to inhibit Renilla luciferase gene. Oligonucleotide-peptide conjugates carrying lysine (Lys) and ornithine (Orn) residues were prepared using the stepwise approa... | 10.1007/s11030-012-9365-2 | 22,392,648 | D045744:Cell Line, Tumor; D057846:Cell-Penetrating Peptides; D015870:Gene Expression; D005822:Genetic Vectors; D006801:Humans; D049409:Luciferases, Firefly; D049410:Luciferases, Renilla; D016376:Oligonucleotides, Antisense; D010455:Peptides; D054735:Phosphorothioate Oligonucleotides; D010957:Plasmids; D011392:Proline; ... | Molecular diversity | 2,012 | D057846:Cell-Penetrating Peptides; D016376:Oligonucleotides, Antisense; D010455:Peptides; D054735:Phosphorothioate Oligonucleotides; C512362:sweet arrow peptide; D011392:Proline; D049410:Luciferases, Renilla; D049409:Luciferases, Firefly |
Dextro-Transposition of Great Arteries and Neurodevelopmental Outcomes: A Review of the Literature. | Background: Arterial switch operation (ASO) is the gold-standard surgical approach for dextro-transposition of the great arteries (D-TGA). It is performed during the neonatal period and has almost diminished the previously high mortality rate (from 90% if left untreated to <0.5%). Despite the impressively high survival... | 10.3390/children9040502 | 35,455,546 | Children (Basel, Switzerland) | 2,022 | ||
Designing a synthetic microbial community through genome metabolic modeling to enhance plant-microbe interaction. | BACKGROUND
Manipulating the rhizosphere microbial community through beneficial microorganism inoculation has gained interest in improving crop productivity and stress resistance. Synthetic microbial communities, known as SynComs, mimic natural microbial compositions while reducing the number of components. However, ach... | 10.1186/s40793-023-00536-3 | 37,974,247 | Environmental microbiome | 2,023 | ||
Leptin levels in patients with type 1 diabetes receiving intensive insulin therapy compared with those in patients receiving conventional insulin therapy. | Several reports suggest that insulin may have a role in the regulation of serum leptin levels, and this is related to the fact that serum leptin levels generally indicate the amount of body fat. Studies show that leptin levels are low in newly diagnosed patients with Type-1 diabetes (T1 DM) and increase after instituti... | 10.1007/BF03345107 | 12,240,905 | D000328:Adult; D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin; D008297:Male | Journal of endocrinological investigation | 2,002 | D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin |
The role of glucagon deficiency in the Houssay phenomenon of dogs. | Plasma glucose, immunoreactive glucagon (IRG), and insulin were measured in hypophysectomized dogs receiving cortisol and thyroid replacement therapy. 4 wk after hypophysectomy mean fasting plasma glucose levels had declined from 90+/-2 mg/100 ml to 64+/-2; fasting and arginine-stimulated insulin and IRG levels were, r... | 10.1172/JCI109053 | 659,597 | D000315:Adrenalectomy; D000818:Animals; D001120:Arginine; D004285:Dogs; D005215:Fasting; D005753:Gastric Mucosa; D005934:Glucagon; D006854:Hydrocortisone; D007016:Hypophysectomy; D007328:Insulin; D010180:Pancreatectomy; D013997:Time Factors | The Journal of clinical investigation | 1,978 | D007328:Insulin; D005934:Glucagon; D001120:Arginine; D006854:Hydrocortisone |
Lp(a) in hypertensive patients. | Lipoprotein(a) (Lp(a)) is considered an important risk factor for coronary disease, cerebrovascular pathology and re-stenosis of coronary bypass. Few studies have been conducted on this lipoprotein in essential arterial hypertensive patients. The purpose of our study was to measure the serum concentrations of Lp(a) and... | 10.1038/sj.jhh.1000540 | 9,504,350 | D000328:Adult; D000368:Aged; D001161:Arteriosclerosis; D005260:Female; D006801:Humans; D006973:Hypertension; D017270:Lipoprotein(a); D008297:Male; D008875:Middle Aged; D012307:Risk Factors | Journal of human hypertension | 1,998 | D017270:Lipoprotein(a) |
Rate dependence of acute PTH release and association between basal plasma calcium and set point of calcium-PTH curve in dialysis patients. | BACKGROUND
In vivo, the control of calcium-mediated acute PTH release during induced hypo- or hypercalcaemia is linked not only to plasma calcium concentration per se but also to the rate and direction of calcium change. In fact, during induced hypocalcaemia, the predominant mechanism that causes PTH to be released is ... | 10.1093/ndt/16.6.1214 | 11,390,723 | D000469:Alkaline Phosphatase; D001639:Bicarbonates; D001786:Blood Glucose; D002118:Calcium; D019587:Dietary Supplements; D005260:Female; D006706:Homeostasis; D006801:Humans; D007676:Kidney Failure, Chronic; D008274:Magnesium; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone; D010710:Phosphates; D012044:Re... | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | 2,001 | D001639:Bicarbonates; D001786:Blood Glucose; D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D000469:Alkaline Phosphatase; D008274:Magnesium; D002118:Calcium |
Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis. | In multiple sclerosis, the immune system attacks the white matter of the brain and spinal cord, leading to disability and/or paralysis. Myelin, oligodendrocytes and neurons are lost due to the release by immune cells of cytotoxic cytokines, autoantibodies and toxic amounts of the excitatory neurotransmitter glutamate. ... | 10.1093/brain/awh156 | 15,130,951 | D000818:Animals; D000911:Antibodies, Monoclonal; D017209:Apoptosis; D001369:Axons; D015815:Cell Adhesion Molecules; D016207:Cytokines; D018450:Disease Progression; D004359:Drug Therapy, Combination; D004681:Encephalomyelitis, Autoimmune, Experimental; D018691:Excitatory Amino Acid Antagonists; D007136:Immunoglobulins; ... | Brain : a journal of neurology | 2,004 | D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D016207:Cytokines; D018691:Excitatory Amino Acid Antagonists; D007136:Immunoglobulins; D016023:Integrins; C489082:Madcam1 protein, mouse; D009088:Mucoproteins; D018696:Neuroprotective Agents; D011810:Quinoxalines; D017470:Receptors, Glutamate; C062865:2,3... |
Anti-inflammatory effect of trans-4-methoxycinnamaldehyde from Etlingera pavieana in LPS-stimulated macrophages mediated through inactivation of NF-κB and JNK/c-Jun signaling pathways and in rat models of acute inflammation. | Trans-4-methoxycinnamaldehyde (MCD) was isolated from the rhizomes of Etlingera pavieana (Pierre ex Gagnep.) R.M.Sm. MCD shows anti-inflammatory effects. However, the molecular mechanism underlying its anti-inflammatory action has not been described. In this study, we investigated this mechanism in lipopolysaccharide (... | 10.1016/j.taap.2019.03.026 | 30,943,385 | D000171:Acrolein; D000480:Alkynes; D000818:Animals; D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D051546:Cyclooxygenase 2; D004195:Disease Models, Animal; D004487:Edema; D004731:Endotoxins; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases; D008262:Macrophage Activation; D008264:Macrophages; D0082... | Toxicology and applied pharmacology | 2,019 | C488838:4-methoxycinnamaldehyde; D000480:Alkynes; D000893:Anti-Inflammatory Agents; D004731:Endotoxins; D016328:NF-kappa B; D010936:Plant Extracts; D016755:Proto-Oncogene Proteins c-jun; C015202:ethylphenylpropiolate; C044101:endotoxin, Escherichia coli; D000171:Acrolein; D002351:Carrageenan; D052247:Nitric Oxide Synth... |
Laparoscopic biliary and enteric bypass. | Very few patients with a periampullary neoplasm present with resectable disease. Consequently, various operative and non-operative techniques have been developed to palliate patients with unresectable periampullary disease. Laparoscopic biliary (cholecystojejunostomy) and enteric bypass (gastrojejunostomy) are reasonab... | 10.1002/(sici)1098-2388(199906)16:4<313::aid-ssu6>3.0.co;2-d | 10,332,777 | D001650:Bile Duct Neoplasms; D002768:Choledochostomy; D003135:Common Bile Duct; D004379:Duodenal Neoplasms; D005260:Female; D005763:Gastroenterostomy; D006801:Humans; D010535:Laparoscopy; D008297:Male; D010166:Palliative Care; D010190:Pancreatic Neoplasms; D011379:Prognosis; D015996:Survival Rate | Seminars in surgical oncology | 1,999 | |
X inactivation, female mosaicism, and sex differences in renal diseases. | A good deal of sex differences in kidney disease is attributable to sex differences in the function of genes on the X chromosome. Males are uniquely vulnerable to mutations in their single copy of X-linked genes, whereas females are often mosaic, having a mixture of cells expressing different sets of X-linked genes. Th... | 10.1681/ASN.2008020198 | 18,448,583 | D018500:Diabetes Insipidus, Nephrogenic; D044127:Epigenesis, Genetic; D000795:Fabry Disease; D053098:Familial Hypophosphatemic Rickets; D005260:Female; D050172:Genes, X-Linked; D040181:Genetic Diseases, X-Linked; D006801:Humans; D007668:Kidney; D007674:Kidney Diseases; D007926:Lesch-Nyhan Syndrome; D008297:Male; D00903... | Journal of the American Society of Nephrology : JASN | 2,008 | |
[Prostatic actinomycosis in a diabetic patient]. | INTRODUCTION
Prostatic localization of actinomycosis is unusual.
CASE REPORT
We report the case of a 59 years-old diabetic man, hospitalised for a prostatic actinomycosis spontaneously fistulised in the rectum. Two species of Actinomyces were found in blood culture and in pus of the fistula.
DISCUSSION
Therapeutic ... | 10.1016/j.revmed.2007.01.018 | 17,320,248 | D000196:Actinomycosis; D048909:Diabetes Complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011469:Prostatic Diseases | La Revue de medecine interne | 2,007 | |
Effects of conversion from a twice-daily tacrolimus to a once-daily tacrolimus on glucose metabolism in stable kidney transplant recipients. | INTRODUCTION
The adverse effects of tacrolimus are known to play major roles in new-onset diabetes after transplantation. The purpose of this study was to investigate the effects of conversion from a twice-daily tacrolimus (Tac-BID) to a once-daily tacrolimus (Tac-OD) on glucose metabolism in stable kidney transplant r... | 24,656,005 | D000328:Adult; D005260:Female; D005947:Glucose; D006801:Humans; D007166:Immunosuppressive Agents; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016559:Tacrolimus | Transplantation proceedings | 2,014 | D007166:Immunosuppressive Agents; D005947:Glucose; D016559:Tacrolimus | |
An Induced Resistance Effect of Hydroxyurea on Plants Infected by Meloidogyne javanica. | Aqueous solutions of hydroxyurea (HU) in various concentrations were applied as soil drenches to Meloidogyne javanica-infected plants. At a concentration of 15 ppm, the chemical hampered giant cell formation and the number of females on the roots was 20% of that of the control but the growth of the host plants was not ... | 19,294,052 | Journal of nematology | 1,985 | |||
Pregnancy and progeny in rats treated with prostaglandin in F2alpha. | The effects of prostaglandin F2alpha on pregnancy and embryonic development were investigated in pregnant rats. The animals were treated with the prostaglandin at a dose of 50 microgram s.c., on gestational days 9 to 11 or 12 to 15. Compared to the controls, only intrauterine growth was significantly altered. The numbe... | 10.1016/0161-4630(78)90073-3 | 715,046 | D000302:Adrenal Cortex; D000818:Animals; D001827:Body Height; D001835:Body Weight; D005260:Female; D005327:Fetal Resorption; D005333:Fetus; D008431:Maternal-Fetal Exchange; D010920:Placenta; D011247:Pregnancy; D011270:Pregnancy, Animal; D011460:Prostaglandins F; D051381:Rats | Prostaglandins and medicine | 1,978 | D011460:Prostaglandins F |
Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner. | UNLABELLED
Fas/CD95 is a critical mediator of cell death in many chronic and acute liver diseases and induces apoptosis in primary hepatocytes in vitro. In contrast, the proinflammatory cytokine tumor necrosis factor α (TNFα) fails to provoke cell death in isolated hepatocytes but has been implicated in hepatocyte apop... | 10.1002/hep.23987 | 20,872,776 | D000818:Animals; D000906:Antibodies; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D051023:BH3 Interacting Domain Death Agonist Protein; D000072224:Bcl-2-Like Protein 11; D053148:Caspase 3; D053179:Caspase 7; D002478:Cells, Cultured; D053222:Fas Ligand Protein; D022781:Hepatocytes; D008107:Liver Diseases; D... | Hepatology (Baltimore, Md.) | 2,011 | D000906:Antibodies; D051017:Apoptosis Regulatory Proteins; D051023:BH3 Interacting Domain Death Agonist Protein; D000072224:Bcl-2-Like Protein 11; C000606776:Bcl2l11 protein, mouse; C494815:Bid protein, mouse; D053222:Fas Ligand Protein; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D014409:Tumor Necrosis... |
Impacts of inter-annual climate variability on reproductive phenology and postnatal development of morphological features of three sympatric bat species. | Inter-annual variation in weather conditions has been shown to affect the reproductive phenological patterns of many organisms. Because of their relatively small body size and dependence on ectothermic prey, temperate-zone insectivorous bats are particularly sensitive to adverse spring environmental conditions that aff... | 10.1038/s41598-023-35781-6 | 37,248,331 | D011247:Pregnancy; D000818:Animals; D005260:Female; D002685:Chiroptera; D012098:Reproduction; D014887:Weather; D036801:Parturition; D012621:Seasons; D004447:Echinodermata; D057231:Climate Change | Scientific reports | 2,023 | |
Breastfeeding among low-income, high-risk women. | Data from a state supported project providing multidiscipline (clinical social work, nursing, nutrition, obstetrics, and pediatrics) assistance to low-income women judged to be at high perinatal risk by medical and social history were analyzed regarding infant feeding decisions. Data from 2,124 subjects delivered from ... | 10.1177/000992288902800109 | 2,910,631 | D000293:Adolescent; D000328:Adult; D001942:Breast Feeding; D002648:Child; D005260:Female; D006801:Humans; D008875:Middle Aged; D009820:Ohio; D011295:Prenatal Care; D012307:Risk Factors; D012959:Socioeconomic Factors | Clinical pediatrics | 1,989 | |
TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C. | OBJECTIVE
The authors determined the endothelial arginine transport mechanism and the potential role of a tumor necrosis factor (TNF)-alpha-mediated signal transduction pathway involving protein kinase C (PKC) in regulating this transport in cultured endothelial cells.
SUMMARY BACKGROUND DATA
The vascular endothelium... | 10.1097/00000658-199505000-00017 | 7,538,287 | D000470:Alkaloids; D000594:Amino Acid Oxidoreductases; D001120:Arginine; D053119:Benzophenanthridines; D001692:Biological Transport; D002148:Calmodulin-Binding Proteins; D002478:Cells, Cultured; D017868:Cyclic AMP-Dependent Protein Kinases; D004730:Endothelium, Vascular; D006801:Humans; D019001:Nitric Oxide Synthase; D... | Annals of surgery | 1,995 | D000470:Alkaloids; D053119:Benzophenanthridines; D002148:Calmodulin-Binding Proteins; D010617:Phenanthridines; D014409:Tumor Necrosis Factor-alpha; D001120:Arginine; C016299:chelerythrine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Ki... |
microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. | Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote glycolysis. However, the role of miR-33a-5p in radiosensitivity rem... | 10.18632/oncotarget.19014 | 29,137,372 | Oncotarget | 2,017 | ||
Diagnosis of pelvic inflammatory disease with 99mtechnetium-hexamethylpropylenamine-oxime-labeled autologous leukocytes and pelvic radionuclide scintigraphy. | In a prospective study, we assessed the performance of pelvic radionuclide scintigraphy after the injection of 99mtechnetium-hexamethylpropylenamine-oxime-labeled autologous leukocytes as a noninvasive tool for the differential diagnosis of pelvic inflammatory disease (PID). The results of radionuclide scintigraphy in ... | 8,469,475 | D005260:Female; D006801:Humans; D010535:Laparoscopy; D007962:Leukocytes; D015609:Organotechnetium Compounds; D010091:Oximes; D000292:Pelvic Inflammatory Disease; D010388:Pelvis; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D019690:Technetium Tc 99m Exametazime | Obstetrics and gynecology | 1,993 | D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime | |
Effect of silica sand on activation energy for diffusion of sodium ions in montmorillonite and silica sand mixture. | The effect of silica sand on the diffusion of sodium ions in mixtures of montmorillonite and silica sand was studied by measuring the apparent diffusion coefficients, activation energies for diffusion, and the basal spacing of the mixed samples. These diffusion experiments suggest that the apparent diffusion coefficien... | 10.1016/S0169-7722(02)00115-8 | 12,598,096 | D001546:Bentonite; D004058:Diffusion; D007477:Ions; D011850:Radioactive Waste; D012822:Silicon Dioxide; D012964:Sodium; D018505:Waste Management; D014961:X-Ray Diffraction | Journal of contaminant hydrology | 2,003 | D007477:Ions; D011850:Radioactive Waste; D001546:Bentonite; D012822:Silicon Dioxide; D012964:Sodium |
Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways. | Previous studies have implicated common and rare genetic variants as risk factors for late-onset Alzheimer's disease (LOAD). Here, weighted burden analysis was applied to over 10,000 exome-sequenced subjects from the Alzheimer's Disease Sequencing Project. Analyses were carried out to investigate whether rare variants ... | 10.1111/ahg.12375 | 32,020,597 | D000544:Alzheimer Disease; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases; D053764:Presenilin-1; D051057:Proto-Oncogene Proteins c-akt; D000073359:Exome Sequencing; D060449:Wnt Signaling Pathway | Annals of human genetics | 2,020 | C508853:PSEN1 protein, human; D053764:Presenilin-1; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D051057:Proto-Oncogene Proteins c-akt |
Genome-wide Identification and Characterization of FCS-Like Zinc Finger (FLZ) Family Genes in Maize (Zea mays) and Functional Analysis of ZmFLZ25 in Plant Abscisic Acid Response. | FCS-like zinc finger family proteins (FLZs), a class of plant-specific scaffold of SnRK1 complex, are involved in the regulation of various aspects of plant growth and stress responses. Most information of FLZ family genes was obtained from the studies in Arabidopsis thaliana, whereas little is known about the potentia... | 10.3390/ijms22073529 | 33,805,388 | D000040:Abscisic Acid; D017360:Arabidopsis; D018506:Gene Expression Regulation, Plant; D018745:Genome, Plant; D055106:Genome-Wide Association Study; D005810:Multigene Family; D009928:Organ Specificity; D010802:Phylogeny; D010940:Plant Proteins; D030821:Plants, Genetically Modified; D013312:Stress, Physiological; D00331... | International journal of molecular sciences | 2,021 | D010940:Plant Proteins; D000040:Abscisic Acid |
Multifunctional l-arginine-based magnetic nanoparticles for multiple-synergistic tumor therapy. | Tumor therapy is facing the big challenge of insufficient treatment. Here, we report high-intensity focused ultrasound (HIFU)-responsive magnetic nanoparticles based on superparamagnetic iron oxide (SPIO, Fe3O4 NPs) as the shell and l-arginine (LA) as the core entrapped by poly-lactide-co-glycolide (PLGA) nanoparticles... | 10.1039/d0bm01932a | 33,507,174 | D001120:Arginine; D045744:Cell Line, Tumor; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D006861:Hydrogen Peroxide; D058185:Magnetite Nanoparticles; D053758:Nanoparticles; D009369:Neoplasms; D059016:Tumor Microenvironment | Biomaterials science | 2,021 | D058185:Magnetite Nanoparticles; D001120:Arginine; D006861:Hydrogen Peroxide |
Mapping the receptor binding regions of human chorionic gonadotropin (hCG) using disulfide peptides of its beta-subunit: possible involvement of the disulfide bonds Cys(9)-Cys(57) and Cys(23)-Cys(72) in receptor binding of the hormone. | Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein hormone essential for the establishment and maintenance of pregnancy. The alpha- and beta-subunits of hCG are highly cross-linked internally by disulfide bonds which seem to stabilize the tertiary structures required for the noncovalent association of t... | 10.1034/j.1399-3011.2001.00866.x | 11,454,166 | D000595:Amino Acid Sequence; D001665:Binding Sites; D001667:Binding, Competitive; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003545:Cysteine; D004220:Disulfides; D006801:Humans; D020128:Inhibitory Concentration 50; D008969:Molecular Sequence Data; D010446:Peptide Fragments; D0... | The journal of peptide research : official journal of the American Peptide Society | 2,001 | D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004220:Disulfides; D010446:Peptide Fragments; D011974:Receptors, LH; D003545:Cysteine |
Limitations and potentials of dual-purpose cow herds in Central Coastal Veracruz, Mexico. | Feed chemical and kinetic composition and animal performance information was used to evaluate productivity limitations and potentials of dual-purpose member herds of the Genesis farmer organization of central coastal Veracruz, Mexico. The Cornell Net Carbohydrate and Protein System model (Version 6.0) was systematicall... | 10.1007/s11250-011-0049-1 | 22,201,012 | D000821:Animal Feed; D000822:Animal Husbandry; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002417:Cattle; D003612:Dairying; D004032:Diet; D004734:Energy Metabolism; D005260:Female; D008800:Mexico; D011247:Pregnancy; D014329:Tropical Climate | Tropical animal health and production | 2,012 | |
Multiple extradural arachnoid cysts: report of two operated cousin cases. | STUDY DESIGN
Report of 2 operated cousin cases of the multiple spinal extradural arachnoid cysts.
OBJECTIVE
To report the operative findings of cousin cases of the multiple spinal extradural arachnoid cysts and analyze a genetic etiology with the pedigree of all family members.
SUMMARY OF BACKGROUND DATA
Spinal ext... | 10.1097/BRS.0b013e31814b8488 | 17,873,800 | D000293:Adolescent; D016080:Arachnoid Cysts; D002648:Child; D004824:Epidural Space; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007796:Laminectomy; D019028:Magnetic Resonance Imaging, Cine; D019060:Minimally Invasive Surgical Procedures; D010375:Pedigree; D012307:Risk Fac... | Spine | 2,007 | |
Serum HSV-1 and 2 IgM in Sexually Transmitted Diseases - More for Screening Less for Diagnosis: An Evaluation of Clinical Manifestation. | BACKGROUND
Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes. Now, HSV-1 has become an important cause and represents even about 30% of genital herpes in some countries. So, study related to genital herpes should consider both HSV-1 and HSV-2.
AIM
To examine trends in HSV-1 and 2 seroprevalence ... | 10.4103/0974-777X.100850 | 23,055,654 | Journal of global infectious diseases | 2,012 | ||
Phase-I study of diacetyl-splenopentin (BCH 069). | BCH 069 is a new synthetic pentapeptide with thymic hormone-like activity. Two groups of patients received 50 mg BCH 069 or placebo by subcutaneous injection for 4 weeks 3 times weekly. The third group of patients received 50 mg BCH 069 by intravenous injection for 6 weeks 3 times weekly. The therapy was carried out du... | 1,982,983 | D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001219:Aspartate Aminotransferases; D002097:C-Reactive Protein; D004341:Drug Evaluation; D006400:Hematocrit; D006801:Humans; D006967:Hypersensitivity; D007136:Immunoglobulins; D008049:Lipase; D050356:Lipid Metabolism; D009842:Oligopeptides; D010446:Peptide Fr... | Allergie und Immunologie | 1,990 | C064311:BCH 069; D007136:Immunoglobulins; D009842:Oligopeptides; D010446:Peptide Fragments; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008049:Lipase; D000469:Alkaline Phosphatase | |
DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Parkinson Study Group. | DATATOP (Deprenyl and tocopherol antioxidative therapy of parkinsonism) is a placebo-controlled clinical trial designed to test the hypothesis that long-term treatment of patients with early Parkinson's disease with deprenyl 10 mg/d and/or tocopherol (vitamin E) 2000 IU/d will extend the time until disability requires ... | 10.1001/archneur.1989.00520460028009 | 2,508,608 | D015331:Cohort Studies; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010300:Parkinson Disease; D010627:Phenethylamines; D016032:Randomized Controlled Trials as Topic; D012642:Selegiline; D014810:... | Archives of neurology | 1,989 | D010627:Phenethylamines; D014810:Vitamin E; D012642:Selegiline |
Humoral immune parameters in serum of gilthead seabream (Sparus aurata L.) after induced skin injury. | Skin lesions contribute to significant rates of morbidity and mortality in fish because they permit the entry of pathogens. Different seric immune parameters (IgM level, protease, antiprotease, peroxidase and lysozyme) and bactericidal activity (against Vibrio harveyi and Photobacterium damsealae) of gilthead seabream ... | 10.1016/j.fsi.2018.02.017 | 29,448,028 | D000818:Animals; D056724:Immunity, Humoral; D021541:Sea Bream; D012867:Skin | Fish & shellfish immunology | 2,018 | |
Conjugates of a photoactivated rhodamine with biopolymers for cell staining. | Conjugates of the photoactivated rhodamine dyes with biopolymers (proteins, polysaccharides, and nucleic acids) are important tools for microscopic investigation of biological tissue. In this study, a precursor of the photoactivated fluorescent dye (PFD) has been successfully used for staining of numerous mammalian cel... | 10.1155/2014/285405 | 25,383,365 | D000818:Animals; D001704:Biopolymers; D058948:Cell Tracking; D005456:Fluorescent Dyes; D057809:HEK293 Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D011506:Proteins; D012235:Rhodamines; D013194:Staining and Labeling | TheScientificWorldJournal | 2,014 | D001704:Biopolymers; D005456:Fluorescent Dyes; D011506:Proteins; D012235:Rhodamines |
The heartbreak of psoriasis: a review of cardiovascular risk in patients with psoriasis. | Psoriasis is a common, chronic, autoimmune condition characterized by excessive growth and differentiation of keratinocytes that affects approximately 1% to 3% of the general population in the United States. Mounting evidence has led to an increasing awareness that psoriasis as a disease is more than "skin deep" and th... | 10.1097/CRD.0000000000000048 | 26,440,534 | D050197:Atherosclerosis; D002318:Cardiovascular Diseases; D006801:Humans; D011565:Psoriasis; D012307:Risk Factors | Cardiology in review | 2,015 | |
Sex differences in the effects of Tyr-MIF-1 on morphine- and stress-induced analgesia. | There is evidence suggesting that the endogenous tetrapeptide, Tyr-MIF-1 (Tyr-Prol-Leu-Gly-amide), has antagonistic or modulatory effects on opioid-mediated analgesia. There is also substantial evidence for sex differences in opioid effects, whereby male rodents display greater levels of opioid-mediated analgesia than ... | 10.1016/0196-9781(92)90038-5 | 1,362,981 | D000595:Amino Acid Sequence; D000698:Analgesia; D000818:Animals; D005260:Female; D009075:MSH Release-Inhibiting Hormone; D008297:Male; D008969:Molecular Sequence Data; D009020:Morphine; D010542:Peromyscus; D012149:Restraint, Physical; D012727:Sex Characteristics; D013312:Stress, Physiological | Peptides | 1,992 | D009020:Morphine; C036930:tyrosyl-prolyl-leucyl-glycinamide; D009075:MSH Release-Inhibiting Hormone |
Sequential identification of organic dyes using the voltammetry of microparticles approach. | An electrochemical method for identifying indigoid, anthraquinonic, naphtoquinonic, flavonoid, pyrone, pyran, and other related dyes in microsamples from works of art is reported using the voltammetry of microparticles methodology. Products of solid state oxidation/reduction of dyes form a layer on the lateral faces of... | 10.1016/j.talanta.2009.12.016 | 20,188,938 | Talanta | 2,010 | ||
Non-typhoidal salmonella bacteraemia among HIV-infected Malawian adults: high mortality and frequent recrudescence. | OBJECTIVE
Non-typhoidal salmonella (NTS) bacteraemia is a common, recurrent illness in HIV-infected African adults. We aimed to describe the presentation and outcome of NTS bacteraemia, the pattern of recurrence, and to determine whether recurrence results from re-infection or recrudescence.
DESIGN
One hundred consec... | 10.1097/00002030-200208160-00009 | 12,172,085 | D000328:Adult; D000900:Anti-Bacterial Agents; D016470:Bacteremia; D018791:CD4 Lymphocyte Count; D002701:Chloramphenicol; D005838:Genotype; D015658:HIV Infections; D006801:Humans; D008295:Malawi; D010641:Phenotype; D012008:Recurrence; D012480:Salmonella Infections; D016019:Survival Analysis | AIDS (London, England) | 2,002 | D000900:Anti-Bacterial Agents; D002701:Chloramphenicol |
Apparent diffusion coefficient value measurements with diffusion magnetic resonance imaging correlated with the expression levels of estrogen and progesterone receptor in breast cancer: A meta-analysis. | AIM
Apparent diffusion coefficient (ADC) value measurement of nodes in diffusion-weighted images (DWI) has been widely used for diagnosis and differential diagnosis of human tumors. We evaluated whether the ADC provided by DWI varies according to the state of estrogen receptors (ER) and progesterone receptors (PR) in b... | 10.4103/0973-1482.150418 | 27,072,207 | D001943:Breast Neoplasms; D002681:China; D038524:Diffusion Magnetic Resonance Imaging; D004967:Estrogens; D005260:Female; D018740:Genetic Heterogeneity; D006801:Humans; D011374:Progesterone; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone | Journal of cancer research and therapeutics | 2,016 | D004967:Estrogens; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone |
Identification of Genetic Risk Factors for Familial Urinary Bladder Cancer: An Exome Sequencing Study. | PURPOSE
Previous studies have shown an approximately two-fold elevation in the relative risk of urinary bladder cancer (UBC) among people with a family history that could not be entirely explained by shared environmental exposures, thus suggesting a genetic component in its predisposition. Multiple genome-wide associat... | 10.1200/PO.21.00115 | 34,964,002 | D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms; D000073359:Exome Sequencing | JCO precision oncology | 2,021 | |
[Evaluation of visits to an emergency department in rural population]. | In an emergency department within a rural population far from a hospital, 1265 patients requested urgent medical care over a 3-year period; they were treated by the duty family physician, who carried out this study. Most patients were residents (insured by Kupat Holim) but a few were inland or foreign tourists. There w... | 8,112,677 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004636:Emergency Service, Hospital; D005260:Female; D006780:Hospitals, Rural; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012424:Rural Population | Harefuah | 1,993 | ||
Increased alpha-hydroxybutyrate dehydrogenase in serum from children with measles. | For treatment and prognostic evaluation of patients with measles, it is important to determine the source of the increase in serum alpha-hydroxybutyrate dehydrogenase (HBD; EC 1.1.99.6). Here we measured HBD and L-lactate dehydrogenase (LD; 1.1.1.27) activities in the serum of 18 children with measles and in 18 age-mat... | 1,582,011 | D002675:Child, Preschool; D004562:Electrocardiography; D005260:Female; D006321:Heart; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase; D007527:Isoenzymes; D007700:Kinetics; D007770:L-Lactate Dehydrogenase; D008214:Lymphocytes; D008297:Male; D008457:Measles; D011379:Prognosis | Clinical chemistry | 1,992 | D007527:Isoenzymes; C035749:2-hydroxybutyrate dehydrogenase; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase | |
[How to treat a thyroid adenocarcinoma inside a branchial cyst]. | The authors reported three cases of branchial cycts containing a thyroid adenocarcinoma. This rare condition imposed a search for the primary tumor. All complementary investigations remained negative as in the few cases reported in the medical literature. A loboisthmectomy for one and a total thyroidectomy for the two ... | 11,965,107 | D000231:Adenocarcinoma, Papillary; D000328:Adult; D001935:Branchioma; D006258:Head and Neck Neoplasms; D006801:Humans; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed | Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris | 2,002 | ||
Smallest lithographic marks generated by optical focusing systems. | We show that the combination of Bessel beams and photosensitive materials exhibiting polarization filtering properties allows one to reach the smallest mark that can be lithographically generated by focusing systems. This property is of interest in current optical data storage techniques. | 10.1364/ol.32.000976 | 17,375,173 | Optics letters | 2,007 | ||
Anxiety and depression in ethnic minorities with chronic heart failure. | BACKGROUND
Considerable evidence confirms the high prevalence of anxiety and depression in the patients with heart failure (HF). However, little is known about the relationship of race/ethnicity to psychosocial variables in this population. The purpose of this study was to examine and compare the incidence of anxiety a... | 10.1016/j.cardfail.2009.03.005 | 19,700,133 | D000328:Adult; D000368:Aged; D001007:Anxiety; D044383:Black People; D002908:Chronic Disease; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003866:Depressive Disorder; D005006:Ethnicity; D005260:Female; D006333:Heart Failure; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D012... | Journal of cardiac failure | 2,009 | |
C-cell-derived calcitonin-free neuroendocrine carcinoma of the thyroid: the diagnostic importance of CGRP immunoreactivity. | In the thyroid, primary neuroendocrine tumors encompass medullary thyroid carcinoma (MTC) and, rarely, other tumors such as paragangliomas. MTCs are derived from C-cells and express calcitonin and neuroendocrine markers. Besides classic MTC, some reports have documented thyroid neuroendocrine tumors, which show no calc... | 10.1177/1066896914525228 | 24,599,901 | D000368:Aged; D002116:Calcitonin; D018278:Carcinoma, Neuroendocrine; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D013964:Thyroid Neoplasms | International journal of surgical pathology | 2,014 | D002116:Calcitonin |
Incisional hernia at the insertion site of the laparoscopic trocar: case report and review of the literature. | Laparoscopic operations offer a myriad of advantages resulting in a rapid postoperative recovery. Incisional hernia is an uncommon cause of morbidity in operative procedures performed by laparoscopic access, and the diagnosis may not be easily made. In our service we identified 2 patients with incisional hernia the sit... | 10.1590/s0041-87812003000400006 | 14,534,675 | D000328:Adult; D000368:Aged; D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis; D005260:Female; D006555:Hernia, Ventral; D006801:Humans; D013525:Surgical Instruments; D020535:Video-Assisted Surgery | Revista do Hospital das Clinicas | 2,003 | |
Identification of putative androgen receptor interaction protein modules: cytoskeleton and endosomes modulate androgen receptor signaling in prostate cancer cells. | We have developed a novel androgen receptor (AR) expression system in the 293 human embryonic kidney cell line that recapitulates AR biochemical activity as a steroid hormone receptor in prostate cancer cells. We used this system to identify putative AR-binding proteins in the cytosolic and nuclear compartments of mamm... | 10.1074/mcp.M600169-MCP200 | 17,052,974 | D000727:Androgen-Binding Protein; D045744:Cell Line, Tumor; D016000:Cluster Analysis; D003599:Cytoskeleton; D011992:Endosomes; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007553:Isotope Labeling; D008297:Male; D008954:Models, Biological; D011471:Prostatic Neoplasms; D011944:Receptors, Androgen; D01... | Molecular & cellular proteomics : MCP | 2,007 | C410798:AR protein, human; D000727:Androgen-Binding Protein; D011944:Receptors, Androgen |
[Recognition of transient evoked otoacoustic emissions]. | OBJECTIVE
To measure the cochlear function more accurately, seeking for a novel method to recognize transient evoked otoacoustic emission (TEOAE) from the recorded signal.
METHODS
Time-frequency domain method was used to effectively recognize TEOAE and stimulating artifact by their different short time Fourier transf... | 12,567,427 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005583:Fourier Analysis; D006319:Hearing Loss, Sensorineural; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae | 1,999 | ||
Value of multidetector-row computed tomography in the preoperative T and N staging of gastric carcinoma: a large-scale Chinese study. | OBJECTIVES
To investigate the value of multidetector-row computed tomography (MDCT) in the preoperative T and N staging of gastric carcinoma and to further investigate the clinicopathological factors affecting the diagnostic accuracy.
METHODS
Seven hundred ninety gastric carcinoma patients underwent preoperative MDCT... | 10.1002/jso.21316 | 19,530,124 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma; D002681:China; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D01130... | Journal of surgical oncology | 2,009 | |
Regional variation in myosin isoforms and phosphorylation at the resting tone in urinary bladder smooth muscle. | Urinary bladder filling and emptying requires coordinated control of bladder body and urethral smooth muscles. Bladder dome, midbladder, base, and urethra showed significant differences in the percentage of 20-kDa myosin light chain (LC20) phosphorylation (35.45 +/- 4.6, 24.7 +/- 2.2, 13.6+/- 2.1, and 12.8 +/- 2.7%, re... | 10.1152/ajpcell.2001.280.2.C254 | 11,208,519 | D000818:Animals; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth; D018995:Myosin Heavy Chains; D018994:Myosin Light Chains; D010766:Phosphorylation; D020033:Protein Isoforms; D012333:RNA, Messenger; D011817:Rabbits; D014521:Urethra; D001743:Urinary Bladder | American journal of physiology. Cell physiology | 2,001 | D018994:Myosin Light Chains; D020033:Protein Isoforms; D012333:RNA, Messenger; D018995:Myosin Heavy Chains |
Genetic markers of Restless Legs Syndrome in Parkinson disease. | INTRODUCTION
Several studies proposed that Restless Legs Syndrome (RLS) and Parkinson disease (PD) may be clinically and/or etiologically related. To examine this hypothesis, we aimed to determine whether the known RLS genetic markers may be associated with PD risk, as well as with PD subtype.
METHODS
Two case-contro... | 25,817,513 | D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins; D006801:Humans; D048671:MAP Kinase Kinase 5; D008297:Male; D008875:Middle Aged; D000075064:Myeloid Ecotropic Viral Integrat... | Parkinsonism & related disorders | 2,015 | C522207:BTBD9 protein, human; D005819:Genetic Markers; D018398:Homeodomain Proteins; C000616391:MEIS1 protein, human; D000075064:Myeloid Ecotropic Viral Integration Site 1 Protein; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D048671:MAP Kinase Kinase 5; C482563:MAP2K5 protei... | |
Exemestane versus anastrozole in postmenopausal women with early breast cancer: NCIC CTG MA.27--a randomized controlled phase III trial. | PURPOSE
In patients with hormone-dependent postmenopausal breast cancer, standard adjuvant therapy involves 5 years of the nonsteroidal aromatase inhibitors anastrozole and letrozole. The steroidal inhibitor exemestane is partially non-cross-resistant with nonsteroidal aromatase inhibitors and is a mild androgen and co... | 10.1200/JCO.2012.44.7805 | 23,358,971 | D000368:Aged; D000077384:Anastrozole; D000730:Androstadienes; D047072:Aromatase Inhibitors; D001943:Breast Neoplasms; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D049671:History, 18th Century; D019584:Hot Flashes; D006801:Humans; D006937:Hypercholesterolemia; D053208:Kaplan-Meier Estimate;... | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | 2,013 | D000730:Androstadienes; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; C056516:exemestane |
Voiding patterns of adult patients who underwent hypospadias repair in childhood. | OBJECTIVE
This study aimed at evaluating the voiding patterns of adult patients who underwent hypospadias repair in childhood.
METHOD
Following IRB approval 103 (22.7%) of 449 adult patients who underwent hypospadias repair between 1978 and 1993 responded to the following questionnaires: International Prostate Sympto... | 10.1016/j.jpurol.2016.08.020 | 27,887,915 | D000328:Adult; D000367:Age Factors; D002648:Child; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D007021:Hypospadias; D008297:Male; D017060:Patient Satisfaction; D012189:Retrospective Studies; D013524:Surgical Flaps; D011795:Surveys and Questionnaires; D013997:Time Factors; D014554:Urination; D0145... | Journal of pediatric urology | 2,017 | |
Double nasoseptal flap technique for endonasal pituitary surgery. | Endoscopic endonasal approach has been successfully used for the management of pituitary tumors; however, the loss of septal mucosa especially around sphenoethmoidal recess and posterior nasal septum might be a disadvantage of this technique. The aim of this study is to describe a variation of the endonasal approach, "... | 10.1007/s00405-016-4314-9 | 27,683,301 | D006801:Humans; D009300:Nasal Septum; D057605:Natural Orifice Endoscopic Surgery; D010911:Pituitary Neoplasms; D013524:Surgical Flaps; D016896:Treatment Outcome | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery | 2,017 | |
Properties of gastroretentive sustained release tablets prepared by combination of melt/sublimation actions of L-menthol and penetration of molten polymers into tablets. | A novel floating sustained release tablet having a cavity in the center was developed by utilizing the physicochemical properties of L-menthol and the penetration of molten hydrophobic polymer into tablets. A dry-coated tablet containing famotidine as a model drug in outer layer was prepared with a L-menthol core by di... | 10.1248/cpb.59.1221 | 21,963,630 | D055598:Chemical Phenomena; D019245:Compressive Strength; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005079:Excipients; D015738:Famotidine; D041981:Gastrointestinal Tract; D006635:Histamine H2 Antagonists; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hy... | Chemical & pharmaceutical bulletin | 2,011 | D003692:Delayed-Action Preparations; D005079:Excipients; D006635:Histamine H2 Antagonists; D011108:Polymers; D013607:Tablets; D014885:Waxes; D008610:Menthol; D015738:Famotidine |
The complex role of social care services in supporting the development of sustainable identities: Insights from the experiences of British South Asian women with intellectual disabilities. | BACKGROUND AND AIMS
Carers and service users with intellectual disabilities from minority ethnic groups have typically been reported to be dissatisfied with the social care services they receive. However, service users themselves have rarely been asked directly about their experiences of social care. This paper aims to... | 10.1016/j.ridd.2017.02.005 | 28,222,961 | D000069:Acculturation; D000328:Adult; D001211:Asia, Western; D001290:Attitude; D005006:Ethnicity; D005260:Female; D006801:Humans; D008607:Intellectual Disability; D008875:Middle Aged; D008913:Minority Groups; D036301:Qualitative Research; D012720:Severity of Illness Index; D012933:Social Identification; D012947:Social ... | Research in developmental disabilities | 2,017 | |
Pre- and postsynaptic actions of serotonin on rat suprachiasmatic nucleus neurons. | Serotoninergic transmission is implicated in the photic and non-photic regulation of circadian rhythms. 5-HT (1-100 microM), carboxamidotryptamine (5-CT 0.1-10 microM) and (+)-8-hydroxy-dipropylaminotetraline (8-OH-DPAT, 1-30 microM) dose-dependently activated an outward current (5-100 pA) in 30% of neurons voltage-cla... | 10.1016/s0006-8993(00)02294-0 | 10,825,500 | D000818:Animals; D002940:Circadian Rhythm; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials; D009433:Neural Inhibition; D009474:Neurons; D015221:Potassium Channels; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin; D012701:Serotonin; D012702:Serotonin Antagonists; D017366:S... | Brain research | 2,000 | D015221:Potassium Channels; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D012701:Serotonin |
Gold nanoparticles generated in ethosome bilayers, as revealed by cryo-electron-tomography. | Gold nanoparticles have been synthesized inside ethosomes, vesicles composed of phospholipid, ethanol, and water, which could be very efficient not only in delivery probes to the skin but also as diagnostic and therapeutic multimodal agents. High efficiency encapsulation of gold nanoparticles is achieved by a simple st... | 10.1021/jp808650e | 19,708,264 | D020285:Cryoelectron Microscopy; D016503:Drug Delivery Systems; D055032:Electron Microscope Tomography; D006046:Gold; D008027:Light; D008051:Lipid Bilayers; D053768:Metal Nanoparticles; D053758:Nanoparticles; D036103:Nanotechnology; D010316:Particle Size; D012492:Salts; D012542:Scattering, Radiation; D012867:Skin; D013... | The journal of physical chemistry. B | 2,009 | D008051:Lipid Bilayers; D012492:Salts; D006046:Gold |
Association between allergic responses and Schistosoma mansoni infection in residents in a low-endemic setting in Brazil. | INTRODUCTION
Schistosomiasis is endemic in 76 countries and territories. Several studies have found an inverse correlation between parasitic disease and the development of allergies. The purpose of the present study was to determine whether infection with Schistosoma mansoni in subjects with a low parasite load is prot... | 25,626,657 | D000485:Allergens; D000818:Animals; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D001938:Brazil; D016022:Case-Control Studies; D005243:Feces; D006801:Humans; D006969:Hypersensitivity, Immediate; D007073:Immunoglobulin E; D010270:Parasite Egg Count; D012550:Schistosoma mansoni; D012555:Schistosomiasis manso... | Revista da Sociedade Brasileira de Medicina Tropical | 2,014 | D000485:Allergens; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007073:Immunoglobulin E | |
Hierarchical composite polyaniline-(electrospun polystyrene) fibers applied to heavy metal remediation. | We describe the in situ preparation of a multipurpose hierarchical polyaniline-polystyrene (PANI-PS) composite based in the chemical polymerization of PANI on nonwoven (NW) electrospun PS mats. We performed a detailed study of the properties of these materials to select the best strategies to incorporate PANI chains in... | 10.1021/acsami.5b00326 | 25,761,543 | D000327:Adsorption; D000814:Aniline Compounds; D008422:Materials Testing; D019216:Metals, Heavy; D053761:Nanocomposites; D057139:Nanofibers; D010316:Particle Size; D011137:Polystyrenes; D016062:Porosity; D013718:Tensile Strength; D014874:Water Pollutants, Chemical; D018508:Water Purification | ACS applied materials & interfaces | 2,015 | D000814:Aniline Compounds; D019216:Metals, Heavy; D011137:Polystyrenes; D014874:Water Pollutants, Chemical; C416807:polyaniline |
Implantation increases tensile strength and collagen content of self-assembled tendon constructs. | Tissue-engineered tendons, derived from an autologous cell source, have the potential to provide an ideal replacement graft that is biologically compatible and has the ability to adapt to the specific mechanical requirements of the in vivo environment. Scaffold-free tendon constructs have been successfully engineered i... | 10.1152/japplphysiol.00921.2009 | 20,110,546 | D000125:Achilles Tendon; D000818:Animals; D000831:Animals, Newborn; D001672:Biocompatible Materials; D001705:Bioprosthesis; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D003094:Collagen; D005260:Female; D005347:Fibroblasts; D006909:Hydroxyproline; D020007:Implants, Experimental; D008297:Male; D008422:Mater... | Journal of applied physiology (Bethesda, Md. : 1985) | 2,010 | D001672:Biocompatible Materials; D003094:Collagen; D006909:Hydroxyproline |
GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila. | BACKGROUND
GATA zinc finger domain containing 2B (GATAD2B) encodes a subunit of the MeCP1-Mi-2/nucleosome remodelling and deacetylase complex involved in chromatin modification and regulation of transcription. We recently identified two de novo loss-of-function mutations in GATAD2B by whole exome sequencing in two unre... | 10.1136/jmedgenet-2012-101490 | 23,644,463 | D000818:Animals; D001483:Base Sequence; D002648:Child; D002872:Chromosome Deletion; D056915:DNA Copy Number Variations; D004330:Drosophila; D005260:Female; D050980:GATA Transcription Factors; D006801:Humans; D008607:Intellectual Disability; D007859:Learning Disabilities; D008969:Molecular Sequence Data; D009154:Mutatio... | Journal of medical genetics | 2,013 | D050980:GATA Transcription Factors; C468770:GATAD2B protein, human; D012097:Repressor Proteins |
Nitric oxide release in response to gut injury. | We evaluated nitric oxide release in several models of intestinal inflammation through luminal nitrite concentrations. In anesthetized rabbits, piglets, and guinea pigs, luminal lavages were collected from loops of normal or injured small intestine. Lavages were analyzed spectrophotometrically for nitrite (Griess reage... | 10.3109/00365529309096062 | 8,382,836 | D000818:Animals; D001647:Bile Acids and Salts; D002199:Capillary Permeability; D002860:Chromium Radioisotopes; D004195:Disease Models, Animal; D004492:Edetic Acid; D004761:Enterocolitis, Pseudomembranous; D004848:Epithelium; D005260:Female; D006168:Guinea Pigs; D007079:Ileitis; D007249:Inflammation; D007410:Intestinal ... | Scandinavian journal of gastroenterology | 1,993 | D001647:Bile Acids and Salts; D002860:Chromium Radioisotopes; D009573:Nitrites; D011506:Proteins; D009569:Nitric Oxide; D014302:Trinitrobenzenesulfonic Acid; D004492:Edetic Acid; D009195:Peroxidase |
The predominance, biodiversity and biotechnological properties of Kluyveromyces marxianus in the production of Pecorino di Farindola cheese. | Pecorino di Farindola is a handicraft cheese made by farmers on small scale using raw ewes' milk and pig rennet. In this study, yeast consortia were evaluated during Pecorino di Farindola making and ripening. Molecular identification of 156 isolates was achieved by a combination of PCR-RFLP of the 5.8S ITS rRNA region ... | 25,038,503 | D000818:Animals; D044822:Biodiversity; D002611:Cheese; D021903:DNA, Ribosomal Spacer; D005516:Food Microbiology; D007716:Kluyveromyces; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012335:RNA, Ribosomal; D015003:Yeasts | International journal of food microbiology | 2,014 | D021903:DNA, Ribosomal Spacer; D012335:RNA, Ribosomal; C065096:RNA, ribosomal, 26S | |
The use and interpretation of anthropometric measures in cancer epidemiology: A perspective from the world cancer research fund international continuous update project. | Anthropometric measures relating to body size, weight and composition are increasingly being associated with cancer risk and progression. Whilst practical in epidemiologic research, where population-level associations with disease are revealed, it is important to be aware that such measures are imperfect markers of the... | 10.1002/ijc.30248 | 27,352,197 | D000886:Anthropometry; D004812:Epidemiologic Methods; D015444:Exercise; D014943:Global Health; D006801:Humans; D007391:International Cooperation; D009369:Neoplasms; D009752:Nutritional Status | International journal of cancer | 2,016 | |
Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. | A cDNA clone of murine macrophage inflammatory protein 2 (MIP-2) has been isolated from a library prepared from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the nucleotide sequence determined. This cDNA was used to clone cDNAs for human homologues of MIP-2 from a library prepared from phorbol myristate aceta... | 10.1084/jem.172.3.911 | 2,201,751 | D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins; D002460:Cell Line; D054426:Chemokine CXCL2; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D003001:Cloning, Molecular; D004247:DNA; D015723:Gene Library; D006801:Humans; D036341:Intercellular Signaling Peptides and Pro... | The Journal of experimental medicine | 1,990 | C499706:CXCL2 protein, human; C499707:CXCL3 protein, human; D002352:Carrier Proteins; D054426:Chemokine CXCL2; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D036341:Intercellular Signaling Peptides and Proteins; D016209:Interleukin-8; D015345:Oligonucleotide Probes; D004247:DNA |
A mobile clinic for the homeless and mentally ill: meeting the needs of a target population. | Six years ago, a home care nurse doing research for a school project discovered a population of elderly, mentally ill, and homeless people who were not receiving adequate health care. The nurse's efforts resulted in her home care agency's expanding its services to include a mobile clinic program. Today, the program emp... | 10,107,057 | D000368:Aged; D006699:Home Care Services; D006801:Humans; D001523:Mental Disorders; D008952:Mobile Health Units; D009515:New Jersey; D014838:Volunteers | Caring : National Association for Home Care magazine | 1,990 | ||
Structure and evolution of chlorate reduction composite transposons. | UNLABELLED
The genes for chlorate reduction in six bacterial strains were analyzed in order to gain insight into the metabolism. A newly isolated chlorate-reducing bacterium (Shewanella algae ACDC) and three previously isolated strains (Ideonella dechloratans, Pseudomonas sp. strain PK, and Dechloromarinus chlorophilus... | 23,919,996 | D001419:Bacteria; D001711:Biotransformation; D002704:Chlorates; D016000:Cluster Analysis; D019295:Computational Biology; D004251:DNA Transposable Elements; D005798:Genes, Bacterial; D053858:Metabolic Networks and Pathways; D010084:Oxidation-Reduction; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequen... | mBio | 2,013 | D002704:Chlorates; D004251:DNA Transposable Elements | |
Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment. | The genetic basis of earlobe attachment has been a matter of debate since the early 20th century, such that geneticists argue both for and against polygenic inheritance. Recent genetic studies have identified a few loci associated with the trait, but large-scale analyses are still lacking. Here, we performed a genome-w... | 10.1016/j.ajhg.2017.10.001 | 29,198,719 | D000293:Adolescent; D000328:Adult; D000818:Animals; D001934:Branchial Region; D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins; D004423:Ear; D053339:Edar Receptor; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D051379:Mice; D008875:Middle Aged; D024101:Mitochondrial Prote... | American journal of human genetics | 2,017 | C488660:ADGRG6 protein, human; D004268:DNA-Binding Proteins; C506008:EDAR protein, human; D053339:Edar Receptor; C569595:KIAA1217 protein, human; C526186:MRPS22 protein, human; D024101:Mitochondrial Proteins; D051764:PAX9 Transcription Factor; C497323:PAX9 protein, human; D011506:Proteins; D043562:Receptors, G-Protein-... |
Prediction of seed gene function in progressive diabetic neuropathy by a network-based inference method. | Guilt by association (GBA) algorithm has been widely used to statistically predict gene functions, and network-based approach increases the confidence and veracity of identifying molecular signatures for diseases. This work proposed a network-based GBA method by integrating the GBA algorithm and network, to identify se... | 10.3892/etm.2019.7441 | 31,007,748 | Experimental and therapeutic medicine | 2,019 | ||
Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients. | BACKGROUND
Eosinophils are pro-inflammatory cells involved in thrombosis and have been proposed as a prognosis marker in acute ischemic stroke and ST-elevation myocardial Infarction. Here, we sought to clarify the prognostic value of eosinophil percentage (EOS%) in patients with acute type A aortic dissection (AAAD).
... | 10.1186/s12872-022-02592-y | 35,366,817 | D000784:Aortic Dissection; D004804:Eosinophils; D006801:Humans; D000083242:Ischemic Stroke; D007958:Leukocyte Count; D011379:Prognosis | BMC cardiovascular disorders | 2,022 | |
Expression of BP1, a novel homeobox gene, correlates with breast cancer progression and invasion. | BACKGROUND
Our previous studies revealed that the mRNA encoded by BP1, a member of the homeobox gene superfamily of transcription factors, was expressed in leukemia and infiltrating breast ductal carcinoma (IDC). This study investigated the immunohistochemical profile of BP1, to determine whether the expression of BP1 ... | 10.1007/s10549-004-4492-9 | 15,830,137 | D001943:Breast Neoplasms; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D018398:Homeodomain Proteins; D006801:Humans; D009361:Neoplasm Invasiveness; D012333:RNA, Messenger; D014157:Transcription Factors | Breast cancer research and treatment | 2,005 | C105304:DLX4 protein, human; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D014157:Transcription Factors |
Fulminant myocarditis in adults: a narrative review. | Fulminant myocarditis (FM) is an uncommon syndrome characterized by sudden and severe hemodynamic compromise secondary to acute myocardial inflammation, often presenting as profound cardiogenic shock, life-threatening ventricular arrhythmias and/or electrical storm. FM may be refractory to conventional therapies and re... | 10.11909/j.issn.1671-5411.2022.02.006 | 35,317,391 | Journal of geriatric cardiology : JGC | 2,022 | ||
MANTA and MANTA-RAy: Rationale and Design of Trials Evaluating Effects of Filgotinib on Semen Parameters in Patients with Inflammatory Diseases. | INTRODUCTION
The phase 2 MANTA and MANTA-RAy studies were developed in consultation with global regulatory authorities to investigate potential impacts of filgotinib, a Janus kinase 1 preferential inhibitor, on semen parameters in men with active inflammatory diseases. Here we describe the methods and rationale for the... | 10.1007/s12325-022-02168-4 | 35,614,292 | D006801:Humans; D015212:Inflammatory Bowel Diseases; D000075242:Janus Kinase Inhibitors; D008297:Male; D011725:Pyridines; D012661:Semen; D013081:Sperm Motility; D014230:Triazoles | Advances in therapy | 2,022 | C584571:GLPG0634; D000075242:Janus Kinase Inhibitors; D011725:Pyridines; D014230:Triazoles |
[Drug therapy with disodium clodronate combined with radiotherapy of bone metastasis of solid tumors]. | The largest portion of a radiation oncologist's practice is aimed at the palliative treatment of bone metastases. This trial investigated the impact of disodiumclodronate on radiation therapy results. Two groups of patients with bone metastases were compared: one (176 patients) treated by radiation therapy alone, the o... | 2,148,401 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms; D004002:Clodronic Acid; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged | La Radiologia medica | 1,990 | D004002:Clodronic Acid | |
Non-sinus bradyarrhythmias in very low birth weight infants. | Transient bradycardias occur frequently in preterm infants with apnea of prematurity. However, occurrence of non-sinus bradyarrhythmias in very low birth weight (VLBW) infants has received very little attention. This case series documents transient bradyarrhythmias in VLBW infants. Most frequently observed arrhythmia w... | 10.1038/sj.jp.7211623 | 17,180,134 | D001919:Bradycardia; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D019102:Infant, Very Low Birth Weight; D008297:Male | Journal of perinatology : official journal of the California Perinatal Association | 2,007 | |
An automated microfluidic platform for calcium imaging of chemosensory neurons in Caenorhabditis elegans. | Functional fluorescence imaging methods are widely used to study cellular physiology. When applied to small organisms, these methods suffer from low-throughput due to the laborious immobilization/stimulus delivery procedure that is typically involved during imaging. Here, we describe the development of an automated mic... | 10.1039/c004658b | 20,820,480 | D000818:Animals; D017173:Caenorhabditis elegans; D020013:Calcium Signaling; D002628:Chemoreceptor Cells; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007090:Image Interpretation, Computer-Assisted; D046210:Microfluidic Analytical Techniques; D008856:Microscopy, Fluorescence; D010812:Physical Stimulati... | Lab on a chip | 2,010 | |
The financial crisis in Italy: implications for the healthcare sector. | The global economic and financial crisis is having and impact on the Italian healthcare system which is undergoing a devolution process from the central government to regions and where about one third of the regional governments (mainly in the central and southern part of the country) are facing large financial deficit... | 10.1016/j.healthpol.2012.04.003 | 22,551,787 | D057172:Economic Recession; D019981:Health Care Sector; D007558:Italy; D009313:National Health Programs | Health policy (Amsterdam, Netherlands) | 2,012 |
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