title large_stringlengths 0 979 | abstract large_stringlengths 1 94.7k | doi large_stringlengths 0 71 | pmid int64 21 38.1M | mesh_terms large_stringlengths 0 1.47k | journal large_stringlengths 1 239 | pubdate int16 1.97k 2.02k | chemical_list large_stringlengths 0 1.47k |
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Proliferation and migration of receptor neurons in the vomeronasal organ of the adult mouse. | Cell proliferation and differentiation in the vomeronasal organ of the adult mouse was studied by bromodeoxyuridine (BrdU) immunohistochemistry coupled to immunostaining for specific markers of the differentiation, such as carnosine, B50-GAP43 (growth-associated protein) and stathmin. The present study shows that three... | 10.1016/s0165-3806(00)00080-8 | 11,020,548 | D000818:Animals; D000963:Antimetabolites; D001973:Bromodeoxyuridine; D002455:Cell Division; D002465:Cell Movement; D004847:Epithelial Cells; D005260:Female; D019922:GAP-43 Protein; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008868:Microtubule Proteins; D018034:Olfactory Rece... | Brain research. Developmental brain research | 2,000 | D000963:Antimetabolites; D019922:GAP-43 Protein; D008868:Microtubule Proteins; D010750:Phosphoproteins; D050777:Stathmin; C493994:Stmn1 protein, mouse; D001973:Bromodeoxyuridine |
Molecularly ordered decanethiolate self-assembled monolayers on Au(111) from in situ cleaved decanethioacetate: an NMR and STM study of the efficacy of reagents for thioacetate cleavage. | The cleavage of decanethioacetate (C10SAc) has been studied by (1)H nuclear magnetic resonance (NMR) spectroscopy and scanning tunneling microscopy (STM) imaging of in situ prepared decanethiolate self-assembled monolayers (SAMs) on Au(111). Solutions of C10SAc (46 mM) and previously reported cleavage reagents (typical... | 10.1021/la100103k | 20,695,562 | Langmuir : the ACS journal of surfaces and colloids | 2,010 | ||
Decompressive craniectomy for elderly patients with traumatic brain injury: it's probably not worth the while. | Decompressive craniectomy (DC) has been regarded as an ultima ratio measure in the treatment of refractory intracranial hypertension after brain injury. Most discussion about its benefits is based on studies performed in patients who are <65 years of age. The aim of this study was to identify patients aged ≥66 years wh... | 10.1089/neu.2011.1889 | 21,639,728 | D000368:Aged; D000369:Aged, 80 and over; D001921:Brain; D001930:Brain Injuries; D003399:Craniotomy; D003627:Data Interpretation, Statistical; D019299:Decompression, Surgical; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006801:Humans; D015601:Injury Severity Score; D019586:Intr... | Journal of neurotrauma | 2,011 | |
Dextropreponderance of corpus luteum rupture. A clinical study. | A retrospective study of 55 consecutive patients with cystic corpora lutea, corpus luteum cysts or hematomas was undertaken to verify the observation of a right-side predominance in the incidence of rupture. Thirty-nine patients had a ruptured corpus luteum diagnosed surgically and confirmed histologically. No differen... | 4,067,947 | D000293:Adolescent; D000328:Adult; D003338:Corpus Luteum; D003560:Cysts; D005260:Female; D006406:Hematoma; D006470:Hemorrhage; D006801:Humans; D008183:Luteal Phase; D011247:Pregnancy; D011271:Pregnancy, Ectopic; D011312:Pressure; D012189:Retrospective Studies; D012422:Rupture, Spontaneous | The Journal of reproductive medicine | 1,985 | ||
Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile. | PURPOSE
Hyperthermia is used to treat several pelvic tumours. An important step in establishing a broader role for hyperthermia in treatment of prostate cancer is verification of an acceptable toxicity profile. In this report, short- and long-term toxicity profiles of a completed phase II trial of transrectal ultrasoun... | 10.1080/02656730500331967 | 16,278,168 | D000368:Aged; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms; D020266:Radiotherapy, Conformal; D012007:Rectum; D014464:Ultrasonic Therapy | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | 2,005 | |
Cognitive impairments after surgical repair of ruptured and unruptured aneurysms. | OBJECTIVES
To determine the frequency and severity of neuropsychological impairments associated with aneurysmal subarachnoid haemorrhage, and associated with repair of intracerebral aneurysms.
METHODS
Two groups of patients who underwent repair of intracerebral aneurysms were studied: patients with unruptured aneurys... | 10.1136/jnnp.69.5.608 | 11,032,612 | D000328:Adult; D017542:Aneurysm, Ruptured; D003072:Cognition Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013345:Subarachnoid Hemorrhage; D013997:Time Factors | Journal of neurology, neurosurgery, and psychiatry | 2,000 | |
2001 Torald Sollmann Award lecture. Looking toward the future, using lessons from the past. | It is a privilege and honor to be selected by the American Society of Pharmacology and Experimental Therapeutics for the Torald Sollmann Award. I wish to take this opportunity to comment on my experiences over the last 40 plus years as both a student and a faculty member. I was trained in pharmacology as well as medici... | 11,356,901 | D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D001363:Awards and Prizes; D003328:Coronary Thrombosis; D016757:Death, Sudden, Cardiac; D004195:Disease Models, Animal; D049673:History, 20th Century; D006801:Humans; D015428:Myocardial Reperfusion Injury; D010600:Pharmacology; D013026:Space Flight; D... | The Journal of pharmacology and experimental therapeutics | 2,001 | D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents | |
Role of Body Mass Index, Waist-to-Height and Waist-to-Hip Ratio in Prediction of Nonalcoholic Fatty Liver Disease. | Objective. To investigate the anthropometric indicators that can effectively predict the nonalcoholic fatty liver disease (NAFLD). Methods. The height, body weight, waist and hip circumference were measured, and body mass index (BMI), waist-to-height (WHtR) and waist-to-hip ratio (WHR) were calculated. M-H chi square t... | 10.1155/2012/362147 | 22,701,476 | Gastroenterology research and practice | 2,012 | ||
Iodido(tri-tert-butyl-phosphane-κP)gold(I). | The Au(I) atom of the title compound, [AuI(C(12)H(27)P)], shows an almost linear coordination, with a P-Au-I angle of 178.52 (3)° [Au-P = 2.2723 (14) Å and Au-I = 2.5626 (6) Å]. | 10.1107/S1600536812018569 | 22,590,185 | Acta crystallographica. Section E, Structure reports online | 2,012 | ||
Perioperative management of patients with DiGeorge syndrome undergoing cardiac surgery. | OBJECTIVE
DiGeorge syndrome is a genetic disorder with multisystem involvement resulting in craniofacial and cardiac anomalies and parathyroid and immune system dysfunction. This study describes perioperative management of a large cohort of patients with DiGeorge syndrome undergoing cardiac surgery.
DESIGN
Retrospect... | 24,461,359 | D006348:Cardiac Surgical Procedures; D002648:Child; D002675:Child, Preschool; D004062:DiGeorge Syndrome; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008910:Minnesota; D019990:Perioperative Care; D011183:Postoperative Complicati... | Journal of cardiothoracic and vascular anesthesia | 2,014 | ||
Dynamic metastability in the two-dimensional Potts ferromagnet. | We investigate the nonequilibrium dynamics of the two-dimensional (2D) Potts model on the square lattice after a quench below the discontinuous transition point. By means of numerical simulations of systems with q=12, 24, and 48, we observe the onset of a stationary regime below the temperature-driven transition, in a ... | 10.1103/PhysRevE.89.052115 | 25,353,747 | D003198:Computer Simulation; D050866:Liquid Crystals; D008280:Magnetics; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D015233:Models, Statistical; D008968:Molecular Conformation; D044367:Phase Transition; D013696:Temperature | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,014 | |
Climate variability and cultural eutrophication at Walden Pond (Massachusetts, USA) during the last 1800 years. | Recent shifts in the ecological condition of Walden Pond, MA, are of potentially wide interest due to the lake's importance as a cultural, historical, and recreational resource in addition to its scientific value as an indicator of local and global environmental change. Algal microfossils in six sediment cores document... | 10.1371/journal.pone.0191755 | 29,617,379 | D057231:Climate Change; D005068:Eutrophication; D005580:Fossils; D008404:Massachusetts; D061005:Ponds | PloS one | 2,018 | |
Extending the effectiveness of home care for elders through low-cost assistive equipment. | A recent demonstration project in Massachusetts suggests that low-technology, low-cost assistive equipment has the potential to make traditional publicly-funded home care programs for elders more effective. The demonstration also identified implementation problems that must be addressed if public home care programs are... | 14,997,908 | D000203:Activities of Daily Living; D000368:Aged; D003362:Cost-Benefit Analysis; D006299:Health Services for the Aged; D006699:Home Care Services; D006801:Humans; D008404:Massachusetts; D019982:Organizational Case Studies; D010865:Pilot Projects; D012656:Self-Help Devices; D013219:State Government; D014481:United State... | Policy brief (Center for Home Care Policy and Research (U.S.)) | 2,001 | ||
The different radiation response and radiation-induced bystander effects in colorectal carcinoma cells differing in p53 status. | Radiation-induced bystander effect, appearing as different biological changes in cells that are not directly exposed to ionizing radiation but are under the influence of molecular signals secreted by irradiated neighbors, have recently attracted considerable interest due to their possible implication for radiotherapy. ... | 26,099,456 | D000230:Adenocarcinoma; D017209:Apoptosis; D024201:Bystander Effect; D045744:Cell Line, Tumor; D016922:Cellular Senescence; D015179:Colorectal Neoplasms; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D020672:I-kappa B Proteins; D015850:Interleukin-6; D016209:Interleukin-8; D015162:... | Mutation research | 2,015 | D020672:I-kappa B Proteins; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; C000606204:NFKBIA protein, human; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D016159:Tumor Suppressor Protein p53; D000072000:NF-KappaB Inhibitor alpha | |
Autism Pathogenesis: The Superior Colliculus. | After been exposed to the visual input, in the first year of life, the brain experiences subtle but massive changes apparently crucial for communicative/emotional and social human development. Its lack could be the explanation of the very high prevalence of autism in children with total congenital blindness. The presen... | 10.3389/fnins.2018.01029 | 30,686,990 | Frontiers in neuroscience | 2,018 | ||
The effectiveness and value of emicizumab and valoctocogene roxaparvovec for the management of hemophilia A without inhibitors. | DISCLOSURES: Funding for this summary was contributed by Arnold Ventures, California Health Care Foundation, The Donaghue Foundation, Harvard Pilgrim Health Care, and Kaiser Foundation Health Plan to the Institute for Clinical and Economic Review (ICER), an independent organization that evaluates the evidence on the va... | 10.18553/jmcp.2021.27.5.667 | 33,908,280 | D018033:Antibodies, Bispecific; D061067:Antibodies, Monoclonal, Humanized; D001777:Blood Coagulation; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D005169:Factor VIII; D015316:Genetic Therapy; D006467:Hemophilia A; D006801:Humans; D018803:Models, Economic; D016896:Treatment Outcome | Journal of managed care & specialty pharmacy | 2,021 | D018033:Antibodies, Bispecific; D061067:Antibodies, Monoclonal, Humanized; C000608208:emicizumab; C078147:F8 protein, human; D005169:Factor VIII |
Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility. | Gliomas are primary brain tumors for which surgical resection and radiotherapy is difficult because of the diffuse infiltrative growth of the tumor into the brain parenchyma. For development of alternative, drug-based, therapies more insight in the molecular processes that steer this typical growth and morphodynamic be... | 10.18632/oncotarget.2366 | 25,238,264 | D000818:Animals; D001932:Brain Neoplasms; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D005910:Glioma; D006801:Humans; D008807:Mice, Inbred ... | Oncotarget | 2,014 | C516895:PTPRZ1 protein, human; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5 |
Binding preferences of the POU domain protein Brain-4: implications for autoregulation. | The POU domain-containing transcription factor Brain-4 (Brn-4, RHS-2) was examined for its sites of expression and DNA binding preferences. In the rat, Brn-4 is expressed in 76 and 65% of vasopressin neurons in the paraventricular and supraoptic nuclei, respectively; but in only 10% of corticotropin-releasing factor ne... | 10.1016/0169-328x(95)00308-f | 8,793,109 | D000225:Adenine; D000818:Animals; D018983:DNA Footprinting; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D006651:Histocytochemistry; D006706:Homeostasis; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009419:Nerve Tissue Pr... | Brain research. Molecular brain research | 1,996 | D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; D050809:POU Domain Factors; C484088:Pou3f4 protein, rat; D014157:Transcription Factors; C074067:Pou3f4 protein, mouse; D000225:Adenine; D013941:Thymine |
The role of tumor necrosis factor-alpha in stress-induced worsening of cerebral ischemia in rats. | Whereas stress is known to be one of the risk factors of stroke, few experimental studies have examined the possible mechanisms by which stress may affect stroke outcome. Most of the knowledge on the effects of stress on cerebrovascular disease in humans is restricted to catecholamines and glucocorticoids effects on bl... | 10.1016/j.neuroscience.2006.06.009 | 16,844,305 | D051722:ADAM Proteins; D000072198:ADAM17 Protein; D000818:Animals; D000906:Antibodies; D001522:Behavior, Animal; D015153:Blotting, Western; D020520:Brain Infarction; D002545:Brain Ischemia; D003345:Corticosterone; D004195:Disease Models, Animal; D018450:Disease Progression; D015227:Lipid Peroxidation; D008297:Male; D05... | Neuroscience | 2,006 | D000906:Antibodies; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha; D052247:Nitric Oxide Synthase Type II; D051722:ADAM Proteins; D000072198:ADAM17 Protein; D003345:Corticosterone |
Evaluation of deep learning for COVID-19 diagnosis: Impact of image dataset organization. | INTRODUCTION
Coronavirus disease 2019 (COVID-19) has spread all over the world showing high transmissibility. Many studies have proposed diverse diagnostic methods based on deep learning using chest X-ray images focusing on performance improvement. In reviewing them, this study noticed that evaluation results might be ... | 10.1002/acm2.13320 | 34,159,697 | D000465:Algorithms; D000086382:COVID-19; D000086742:COVID-19 Testing; D000077321:Deep Learning; D006801:Humans; D000086402:SARS-CoV-2 | Journal of applied clinical medical physics | 2,021 | |
PARK2 regulates eIF4B-driven lymphomagenesis. | Patients with high-risk diffuse large B-cell lymphoma (DLBCL) have poor outcomes following first-line cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab (R-CHOP); thus, treatment of this fatal disease remains an area of unmet medical need and requires identification of novel therapeutic approaches. D... | 10.1158/1541-7786.MCR-21-0729 | 35,191,952 | Molecular cancer research : MCR | 2,022 | ||
Cerebral oxygenation declines despite maintained orthostatic tolerance after brief exposure to gravitational stress. | We examined the effect of a single 120 s of exposure to +3Gz (head-to-foot inertial forces) centrifugation as orthostatic stress on cerebral oxygenation (oxy-Hb) and cerebral blood volume (CBV) changes in response to stand test, in order to relate the occurrence of altered cerebral oxygenation control to any increase i... | 10.1016/j.neulet.2005.01.041 | 15,854,774 | D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001921:Brain; D002560:Cerebrovascular Circulation; D004562:Electrocardiography; D004569:Electroencephalography; D004576:Electromyography; D007839:Functional Laterality; D006112:Gravitation; D006339:Heart Rate; D006454:Hemoglobins; D006801:Humans; D007... | Neuroscience letters | 2,005 | D006454:Hemoglobins |
Merkel cell polyomavirus and p63 status in Merkel cell carcinoma by immunohistochemistry: Merkel cell polyomavirus positivity is inversely correlated with sun damage, but neither is correlated with outcome. | The aim of this study was to determine the frequency of Merkel cell polyomavirus (MPyV) and p63 positivity by immunohistochemistry in a large cohort of primary Merkel cell carcinoma (MCC) from a region with high rates of actinic damage. We also aimed to determine whether there is any relationship between these markers ... | 10.1097/PAT.0000000000000069 | 24,614,722 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D015266:Carcinoma, Merkel Cell; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008565:Membrane Proteins; D059965:Merkel cell ... | Pathology | 2,014 | D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D008565:Membrane Proteins |
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. | The major myeloid blood cell lineages are generated from hematopoietic stem cells by differentiation through a series of increasingly committed progenitor cells. Precise characterization of intermediate progenitors is important for understanding fundamental differentiation processes and a variety of disease states, inc... | 10.1016/j.stem.2007.07.005 | 18,371,379 | D000818:Animals; D015703:Antigens, CD; D001792:Blood Platelets; D002451:Cell Compartmentation; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002469:Cell Separation; D002999:Clone Cells; D000071063:Endoglin; D015672:Erythroid Precursor Cells; D020869:Gene Expression Profiling; D005786:... | Cell stem cell | 2,007 | D015703:Antigens, CD; D000071063:Endoglin; C502004:Eng protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1 |
Metabolism and Mental Illness. | Over the past century, overwhelming evidence has emerged pointing to the hypothalamus of the central nervous system (CNS) as a crucial regulator of systemic control of metabolism, including appetite and feeding behavior. Appetite (or hunger) is a fundamental driver of survival, involving complex behaviors governed by v... | 10.1016/j.molmed.2015.12.003 | 26,776,095 | D000928:Antidepressive Agents; D002540:Cerebral Cortex; D003863:Depression; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders; D005786:Gene Expression Regulation; D054439:Ghrelin; D006801:Humans; D007031:Hypothalamus; D007328:Insulin; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Fac... | Trends in molecular medicine | 2,016 | D000928:Antidepressive Agents; D054439:Ghrelin; D007328:Insulin; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; D020738:Leptin; D012701:Serotonin |
[Diffuse pulmonary infiltration at the onset of Waldenström's disease]. | The case of an 52 years old female presenting dyspnea and pulmonary infiltration is reported. A transbronchial biopsy showing a lymphomatous infiltrate with immunohistochemistry using anti-IgM antibody on paraffine embedded section helped to diagnose. A monoclonal increase in seric immunoglobin M, led to the diagnosis ... | 7,638,428 | D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008171:Lung Diseases; D008875:Middle Aged; D012008:Recurrence; D008258:Waldenstrom Macroglobulinemia | Revue des maladies respiratoires | 1,995 | D007074:Immunoglobulin G; D007075:Immunoglobulin M | |
The significance of necrotic mediastinal lymph nodes on CT in patients with newly diagnosed Hodgkin disease. | Necrosis in lymph nodes shown on CT in many patients with nodal metastases may indicate that the primary tumor is aggressive and has a high degree of malignancy. However, the significance of nodal necrosis in patients with mediastinal Hodgkin disease remains uncertain. We studied the thoracic CT scans of 76 patients wh... | 10.2214/ajr.155.2.2115249 | 2,115,249 | D000328:Adult; D005260:Female; D006689:Hodgkin Disease; D006801:Humans; D008198:Lymph Nodes; D008297:Male; D008479:Mediastinal Neoplasms; D008482:Mediastinum; D009336:Necrosis; D013997:Time Factors; D014057:Tomography, X-Ray Computed | AJR. American journal of roentgenology | 1,990 | |
Photoinduced electron transfer occurs between 2-aminopurine and the DNA nucleic acid monophosphates: results from cyclic voltammetry and fluorescence quenching. | 2-Aminopurine (2AP) is a fluorescent adenine analogue that is useful in part because its substantial fluorescence quantum yield is sensitive to base stacking with native bases in ss- and ds-DNA. However, the degree of quenching is sequence dependent and the mechanism of quenching is still a matter of some debate. Here ... | 10.1021/jp102355v | 20,734,496 | D015075:2-Aminopurine; D004247:DNA; D055664:Electrochemical Techniques; D004579:Electron Transport; D008027:Light; D015394:Molecular Structure; D009711:Nucleotides; D010084:Oxidation-Reduction; D013050:Spectrometry, Fluorescence | The journal of physical chemistry. B | 2,010 | D009711:Nucleotides; D015075:2-Aminopurine; D004247:DNA |
[Evaluation of the website of the Nord-Pas-de-Calais regional pharmacovigilance center]. | We posted the Nord-Pas-de-Calais regional pharmacovigilance center website and distributed a survey to its potential users between August 2014 and October 2014 (135 general practitioners, 45 pharmacists, 14 patients). Satisfaction was 7.3±1.6 out of 10 points for the visual aspect, 7.8±1.5 out of 10 points for navigati... | 27,235,657 | D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D003258:Consumer Behavior; D054626:Consumer Health Information; D005260:Female; D005602:France; D058005:General Practitioners; D006801:Humans; D020407:Internet; D008297:Male; D017060:Patient Satisfaction; D010595:Pharmacists; D060735:Pharmacovigilance | Therapie | 2,016 | ||
Characterization of lattice defects in strontium titanate single crystals by X-ray topography and transmission electron microscopy | Lattice defects in SrTiO3 single crystals were characterized by X-ray topography and transmission electron microscopy. We examined two groups of crystals whose lapped faces were (001) and (011), respectively. After taking X-ray topographs, crystals which included relatively many defects were chosen for detailed investi... | 10.1093/oxfordjournals.jmicro.a023797 | 10,791,425 | Journal of electron microscopy | 2,000 | ||
[Rhinitis and asthma in a cleaner of laboratory animal facilities]. | After 15 years as a cleaner of laboratory animal facilities, a 59-year-old woman developed rhinitis and then mild asthma. One of her main job tasks was manual cleaning of cages. Her symptoms appeared shortly after an automatic cage washer was introduced where she placed dirty cages upside down, some of them above her h... | 18,489,881 | D000485:Allergens; D017750:Animal Technicians; D000818:Animals; D000830:Animals, Laboratory; D001249:Asthma; D016535:Bronchial Hyperreactivity; D005260:Female; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases; D051381:Rats; D012221:Rhinitis, Allergic, Perennial | Ugeskrift for laeger | 2,008 | D000485:Allergens | |
[Influenza vaccination in pregnant women. Coverage, practices and knowledge among obstetricians]. | BACKGROUND AND OBJECTIVES
Women who are pregnant during influenza season have an increased risk of infection and severe clinical disease. Several national and international organizations currently recommend vaccination for pregnant women. We intended to estimate the influenza vaccination rate in a population of postpar... | 10.1016/j.medcli.2009.10.004 | 19,942,237 | D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human; D009774:Obstetrics; D010818:Practice Patterns, Physicians'; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D014611:Vaccina... | Medicina clinica | 2,010 | D007252:Influenza Vaccines |
Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier. | Pain is a dominant symptom associated with inflammatory conditions. Pharmacotherapy with opioids may be limited by poor blood-brain barrier (BBB) permeability. One approach that may improve central nervous system (CNS) delivery is to target endogenous BBB transporters such as organic anion-transporting polypeptide 1a4 ... | 10.1124/jpet.110.174151 | 21,131,267 | D000818:Animals; D001812:Blood-Brain Barrier; D005260:Female; D005786:Gene Expression Regulation; D018836:Inflammation Mediators; D027361:Organic Anion Transporters; D010146:Pain; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D053773:Transforming Growth Factor beta1 | The Journal of pharmacology and experimental therapeutics | 2,011 | D018836:Inflammation Mediators; D027361:Organic Anion Transporters; C503597:Slco1a4 protein, rat; D053773:Transforming Growth Factor beta1 |
Activity of citrinin metabolized by rat and human microsome fractions in clastogenicity and SCE assays on Chinese hamster V79-E cells. | The mycotoxin citrinin is a potent inducer of chromosomal aberrations in the clastogenicity assay on V79-E cells when metabolized by rat and human liver microsomes. Rat and human liver microsomes, standardized on protein content, activate citrinin at equal levels. 5 X 10(-4) M citrinin induces complex translocations in... | 10.1016/0165-1218(79)90028-4 | 481,457 | D000818:Animals; D001578:Benzopyrans; D001711:Biotransformation; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes; D002953:Citrinin; D006224:Cricetinae; D003434:Crossing Over, Genetic; D004353:Drug Evaluation, Preclinical; D008168:Lung; D008861:Microsomes; D009153:Mutagens | Mutation research | 1,979 | D001578:Benzopyrans; D009153:Mutagens; D002953:Citrinin |
Association between serum organochlorines and global methylation level of leukocyte DNA among Japanese women: a cross-sectional study. | While the global methylation level of leukocyte DNA may be a suitable biomarker for cancer risk, the level may be influenced by multiple factors, both environmental and host-related, one of which is exposure to environmental pollutants. To date, three epidemiologic studies have examined associations between serum organ... | 24,880,549 | D000328:Adult; D003430:Cross-Sectional Studies; D019175:DNA Methylation; D004781:Environmental Exposure; D004785:Environmental Pollutants; D004787:Environmental Pollution; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007564:Japan; D007962:Leukocytes; D008875:Middle ... | The Science of the total environment | 2,014 | D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated | |
Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis. | Intratumor heterogeneity associates with cancer progression and may account for a substantial portion of therapeutic resistance. Although extensive studies have focused on the origin of the heterogeneity, biological interactions between heterogeneous malignant cells within a tumor are largely unexplored. Glioblastoma (... | 10.1242/jcs.225714 | 30,665,893 | D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis; D001932:Brain Neoplasms; D063646:Carcinogenesis; D018797:Cell Cycle Proteins; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma; D064593:Heterografts; D006801:Humans; D051379:Mice; ... | Journal of cell science | 2,019 | D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D000091102:YAP-Signaling Proteins; C486223:Yap1 protein, mouse |
Chronic continuous PTH infusion results in hypertension in normal subjects. | The factors responsible for the frequent occurrence of hypertension in patients with primary hyperparathyroidism have not been elucidated. Suggested mediators have included hypercalcemia, renal insufficiency, and increased plasma renin activity. However, experimental results have not been reported in any species that t... | 3,543,230 | D000328:Adult; D001794:Blood Pressure; D005938:Glucocorticoids; D006706:Homeostasis; D006801:Humans; D006934:Hypercalcemia; D006961:Hyperparathyroidism; D006973:Hypertension; D007262:Infusions, Intravenous; D008297:Male; D008901:Mineralocorticoids; D010281:Parathyroid Hormone; D012083:Renin; D013997:Time Factors | Journal of clinical hypertension | 1,986 | D005938:Glucocorticoids; D008901:Mineralocorticoids; D010281:Parathyroid Hormone; D012083:Renin | |
Cell shape dynamics during the staphylococcal cell cycle. | Staphylococcus aureus is an aggressive pathogen and a model organism to study cell division in sequential orthogonal planes in spherical bacteria. However, the small size of staphylococcal cells has impaired analysis of changes in morphology during the cell cycle. Here we use super-resolution microscopy and determine t... | 10.1038/ncomms9055 | 26,278,781 | D001426:Bacterial Proteins; D002453:Cell Cycle; D002473:Cell Wall; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D009997:Osmotic Pressure; D010957:Plasmids; D013211:Staphylococcus aureus | Nature communications | 2,015 | D001426:Bacterial Proteins |
Single Port vs. Four Port Cholecystectomy--Randomized Trial on Quality of Life. | BACKGROUND
Classical laparoscopic cholecystectomy involves four ports while most novel 'single port' technique only requires one incision on the abdominal wall. This technique is thought to decrease surgical trauma and improve cosmesis although there are reports pointing out that classical laparoscopic cholecystectomy ... | 10.17219/acem/43713 | 26,467,136 | D000328:Adult; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D006304:Health Status; D046449:Hernia, Abdominal; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D010149:Pain, Postoperative; D017060:Patient Satisfaction; D011446:Prospective Studies; D011788:Quali... | Advances in clinical and experimental medicine : official organ Wroclaw Medical University | 2,015 | |
Fresh and frozen-thawed sperm quality, nuclear DNA integrity, invitro fertility, embryo development, and live-born offspring of N-ethyl-N-nitrosourea (ENU) mice. | Efficient collection, freezing, reliable archiving of sperm, and re-derivation of mutant mice are essential components for large-scale mutagenesis programs in the mouse. Induced mutations (i.e. transgenes, targeted mutations, chemically induced mutations) in mice may cause inherited or temporary sterility, increase abn... | 10.1016/j.cryobiol.2008.07.007 | 18,700,137 | D000177:Acrosome; D000818:Animals; D001755:Blastocyst; D048429:Cell Size; D002470:Cell Survival; D015925:Cryopreservation; D053938:DNA Fragmentation; D046149:Embryo Culture Techniques; D004624:Embryo Transfer; D047108:Embryonic Development; D005038:Ethylnitrosourea; D005260:Female; D005298:Fertility; D005307:Fertilizat... | Cryobiology | 2,008 | D005038:Ethylnitrosourea |
Antimicrobial activity of Metschnikowia pulcherrima on wine yeasts. | AIMS
In the present study, it was investigated the antagonistic behaviour of Metschnikowia pulcherrima, as biocontrol agent, against the main wine yeast species involved in the winemaking process.
METHODS AND RESULTS
Seven strains of M. pulcherrima were evaluated for the antimicrobial activity against 114 yeast strai... | 10.1111/jam.12446 | 24,443,784 | D000898:Antibiosis; D000935:Antifungal Agents; D061046:Biological Control Agents; D055163:Metschnikowia; D014920:Wine; D015003:Yeasts | Journal of applied microbiology | 2,014 | D000935:Antifungal Agents; D061046:Biological Control Agents |
Preventing kidney injury among sugarcane workers: promising evidence from enhanced workplace interventions. | OBJECTIVES
To assess if improvement of working conditions related to heat stress was associated with improved kidney health outcomes among sugarcane harvest workers in Chichigalpa, Nicaragua, a region heavily affected by the epidemic of chronic kidney disease of non-traditional origin.
METHODS
Based on our findings d... | 10.1136/oemed-2020-106406 | 32,404,530 | D058186:Acute Kidney Injury; D000328:Adult; D015331:Cohort Studies; D003404:Creatinine; D003681:Dehydration; D000067565:Farmers; D005260:Female; D005919:Glomerular Filtration Rate; D015989:Healthy Worker Effect; D018882:Heat Stress Disorders; D006801:Humans; D008297:Male; D009527:Nicaragua; D009784:Occupational Disease... | Occupational and environmental medicine | 2,020 | D003404:Creatinine |
The role of erythrocyte aggregation in the abnormal hemorheology of multiple myeloma patients. | OBJECTIVES
The aim of this study is to clarify whether increased aggregation of red blood cells (RBCs) of multiple myeloma (MM) patients is caused by changes in plasma chemical composition or is associated with alterations in RBC properties and in addition, to suggest an approach to revert the enhanced aggregation in M... | 16,687,792 | D000368:Aged; D000369:Aged, 80 and over; D004903:Erythrocyte Aggregation; D004910:Erythrocyte Membrane; D005260:Female; D018056:Hemorheology; D006801:Humans; D007136:Immunoglobulins; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma; D010949:Plasma | Clinical hemorheology and microcirculation | 2,006 | D007136:Immunoglobulins | |
Sequential use of extracorporeal membrane oxygenation and the Berlin Heart Left Ventricular Assist Device for 106-day bridge to transplant in a two-year-old child. | We describe a 2 year-old girl with end-stage dilated cardiomyopathy in whom extracorporeal membrane oxygenation (ECMO) was used for mechanical cardiac assistance. After 4 weeks, ECMO-related complications necessitated change to a Berlin Heart Left Ventricular Assist Device (LVAD), and she received a successful cardiac ... | 10.1097/01.mat.0000174624.36385.94 | 16,322,738 | D002311:Cardiomyopathy, Dilated; D002675:Child, Preschool; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left | ASAIO journal (American Society for Artificial Internal Organs : 1992) | 2,005 | |
An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - Are your sorted cells getting SICS? | Flow cytometry and fluorescence-activated cell sorting have become invaluable tools to analyze and isolate specific cell populations in a wide range of biomedical research and clinical applications. In countless approaches worldwide, scientists are using single cell analyses to better understand the significance and va... | 10.1016/j.jim.2020.112902 | 33,069,766 | D015496:CD4-Positive T-Lymphocytes; D049109:Cell Proliferation; D002469:Cell Separation; D002470:Cell Survival; D002478:Cells, Cultured; D005434:Flow Cytometry; D006801:Humans; D007963:Leukocytes, Mononuclear; D010641:Phenotype; D011312:Pressure; D013314:Stress, Mechanical; D013997:Time Factors | Journal of immunological methods | 2,020 | |
Interaction between selected bacterial strains and Arabidopsis halleri modulates shoot proteome and cadmium and zinc accumulation. | The effects of plant-microbe interactions between the hyperaccumulator Arabidopsis halleri and eight bacterial strains, isolated from the rhizosphere of A. halleri plants grown in a cadmium- and zinc-contaminated site, were analysed for shoot metal accumulation, shoot proteome, and the transcription of genes involved i... | 10.1093/jxb/err015 | 21,357,773 | D017360:Arabidopsis; D029681:Arabidopsis Proteins; D001419:Bacteria; D015153:Blotting, Western; D002104:Cadmium; D018506:Gene Expression Regulation, Plant; D010802:Phylogeny; D018520:Plant Shoots; D016133:Polymerase Chain Reaction; D020543:Proteome; D015032:Zinc | Journal of experimental botany | 2,011 | D029681:Arabidopsis Proteins; D020543:Proteome; D002104:Cadmium; D015032:Zinc |
Spontaneous regression of a large skull base meningioma: case report. | We present the case of a 58 year old lady with a large middle cranial fossa meningioma (5 cm × 4 cm in maximal dimensions) which has considerably regressed without any treatment during seven years of follow up. While the tumour had remained radiologically static for the first three years, scans from year five post-diag... | 10.1080/02688697.2018.1426728 | 29,334,772 | D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms; D008579:Meningioma; D008875:Middle Aged; D019291:Skull Base; D019292:Skull Base Neoplasms | British journal of neurosurgery | 2,020 | |
High-Throughput Sequencing Approach to Analyze the Effect of Aging Time and Barrel Usage on the Microbial Community Composition of Red Wines. | Wine aged in barrels or bottles is susceptible to alteration by microorganisms that affect the final product quality. However, our knowledge of the microbiota during aging and the factors modulating the microbial communities is still quite limited. The present work uses high-throughput sequencing (HTS) techniques to de... | 10.3389/fmicb.2020.562560 | 33,013,793 | Frontiers in microbiology | 2,020 | ||
Computerized prescription checking system. | This is a report on a validation system which was developed by utilizing medication history profiles of drugs prescribed to patients. Upon entering the current prescription data of a patient, the system will automatically retrieve the patient's history of past medication and the previous prescription, and print out the... | 10.1016/0020-7101(86)90064-4 | 3,804,475 | D003199:Computer Systems; D004347:Drug Interactions; D011307:Drug Prescriptions; D006801:Humans; D008499:Medical Records | International journal of bio-medical computing | 1,986 | |
Virus infections of the respiratory tract cytopathologic and clinical analysis. | Thirty-three cases of respiratory tract virus infections diagnosed cytologically are reviewed. The clinical and demographic data are presented and correlated with an analysis of the cytologic findings. Herpes virus was the most common infection. It occurred in patients with other severe medical problems and had little ... | 189,546 | D000257:Adenoviridae Infections; D000258:Adenovirus Infections, Human; D000328:Adult; D000368:Aged; D002648:Child; D003581:Cytodiagnosis; D003586:Cytomegalovirus Infections; D005260:Female; D006566:Herpesviridae Infections; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D012141:Re... | Acta cytologica | 1,977 | ||
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. | The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain and in the N-terminal transactivation domain. In this study we investigated the messenger RNA expression of both ER subtypes in rat tissues by RT-PCR and compared the ligand binding specific... | 10.1210/endo.138.3.4979 | 9,048,584 | D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D006801:Humans; D007536:Isomerism; D008024:Ligands; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger; D051381:Rats; D011960:Receptors, Estrogen; D014018:Tissue Distribution | Endocrinology | 1,997 | D008024:Ligands; D012333:RNA, Messenger; D011960:Receptors, Estrogen |
Dynamics of ethylene-propylene random copolymers by (1)H and (13)C solid-state NMR. | The dynamic behavior of three completely amorphous ethylene-propylene random copolymers with slightly different structural properties was investigated by means of a multifrequency global fitting approach, presented in a previous paper. To this end, the trends of NMR (1)H and (13)C spin-lattice relaxation times with tem... | 10.1021/jp111435s | 21,319,756 | The journal of physical chemistry. B | 2,011 | ||
N-acetylcysteine effectively diminished meconium-induced oxidative stress in adult rabbits. | Since inflammation and oxidative stress are fundamental in the pathophysiology of neonatal meconium aspiration syndrome (MAS), various anti-inflammatory drugs have been used in experimental and clinical studies on MAS. This pilot study evaluated therapeutic potential of N-acetylcysteine in modulation of meconium-induce... | 25,716,970 | D000111:Acetylcysteine; D000367:Age Factors; D000818:Animals; D000975:Antioxidants; D015415:Biomarkers; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D018836:Inflammation Mediators; D007962:Leukocytes; D015227:Lipid Peroxidation; D008168:Lung; D055370:Lung Injury; D008470:Meconium; D008471:Me... | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society | 2,015 | D000975:Antioxidants; D015415:Biomarkers; D018836:Inflammation Mediators; D017392:Thiobarbituric Acid Reactive Substances; D000111:Acetylcysteine | |
Relationships between soil and runoff phosphorus in small Alberta watersheds. | Field-scale relationships between soil test phosphorus (STP) and flow-weighted mean concentrations (FWMCs) of dissolved reactive phosphorus (DRP) and total phosphorus (TP) in runoff are essential for modeling phosphorus losses, but are lacking. The objectives of this study were (i) to determine the relationships betwee... | 10.2134/jeq2006.0502 | 17,636,290 | D000416:Alberta; D004784:Environmental Monitoring; D010758:Phosphorus; D011891:Rain; D012621:Seasons; D012987:Soil; D014872:Water Movements | Journal of environmental quality | 2,007 | D012987:Soil; D010758:Phosphorus |
Pyrenoid loss impairs carbon-concentrating mechanism induction and alters primary metabolism in Chlamydomonas reinhardtii. | Carbon-concentrating mechanisms (CCMs) enable efficient photosynthesis and growth in CO2-limiting environments, and in eukaryotic microalgae localisation of Rubisco to a microcompartment called the pyrenoid is key. In the model green alga Chlamydomonas reinhardtii, Rubisco preferentially relocalises to the pyrenoid dur... | 10.1093/jxb/erx121 | 28,520,898 | D020418:Algal Proteins; D002244:Carbon; D016825:Chlamydomonas reinhardtii; D002736:Chloroplasts; D015870:Gene Expression; D059014:High-Throughput Nucleotide Sequencing; D010788:Photosynthesis; D017422:Sequence Analysis, DNA | Journal of experimental botany | 2,017 | D020418:Algal Proteins; D002244:Carbon |
Assessment of hybrid vigour, dominance effect and hybrids regeneration potential in the genus Citrullus. | The current research was directed to explore hybrid vigour for hybrids resulting from crosses among six genotypes of the genus Citrullus, including C. mucosospermus. For such purpose, the mid parent heterosis and the best parent heterosis were assessed. Non parametric method related to homogeneity Chi-square at 5 % lik... | 10.1016/j.heliyon.2020.e05005 | 33,005,805 | Heliyon | 2,020 | ||
Non-Antarctic notothenioids: Past phylogenetic history and contemporary phylogeographic implications in the face of environmental changes. | The non-Antarctic Notothenioidei families, Bovichtidae, Pseudaphritidae and Eleginopsidae, diverged early from the main notothenioid lineage. They are important in clarifying the early evolutionary processes that triggered notothenioid evolution in the Antarctic. The early-diverged group represents 8% of all notothenio... | 10.1016/j.margen.2015.11.007 | 26,610,933 | D063147:Animal Distribution; D000818:Animals; D057231:Climate Change; D005399:Fishes; D010802:Phylogeny; D058974:Phylogeography | Marine genomics | 2,016 | |
A Dual Pandemic: The Influence of Coronavirus Disease 2019 on Trends and Types of Firearm Violence in California, Ohio, and the United States. | BACKGROUND
This study sought to determine the impact of coronavirus disease 2019 stay-at-home (SAH) and reopening orders on trends and types of firearm violence in California, Ohio, and the United States, hypothesizing increased firearm violence after SAH.
MATERIALS AND METHODS
Retrospective data (January 1, 2018, to... | 10.1016/j.jss.2021.01.018 | 33,621,746 | D000086382:COVID-19; D002140:California; D005389:Firearms; D006801:Humans; D009820:Ohio; D012189:Retrospective Studies; D000086402:SARS-CoV-2; D014481:United States; D014754:Violence; D014948:Wounds, Gunshot | The Journal of surgical research | 2,021 | |
Minimal model to document psychometric change after standard anterior temporal lobectomy for intractable seizure disorder. | Neuropsychological assessment of persons with epilepsy is recommended whenever neurosurgery is considered as an alternative therapy for seizure disorders refractory to ordinary medical management. Although psychological assessment is common in centers specialized in the care of epilepsy patients, standardized protocols... | 10.1002/jclp.10185 | 12,945,060 | D000293:Adolescent; D000328:Adult; D003072:Cognition Disorders; D023381:Endpoint Determination; D004827:Epilepsy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008569:Memory Disorders; D008875:Middle Aged; D008960:Models, Psychological; D019635:Neurosurgical P... | Journal of clinical psychology | 2,003 | |
Development of a bioactive implant for repair and potential healing of cranial defects. | The repair of complex craniofacial bone defects is challenging and a successful result is dependent on the size of the defect, quality of the soft tissue covering the defect, and choice of reconstruction method. The objective of this study was to develop a bioactive cranial implant that could provide a permanent recons... | 10.3171/2013.6.JNS1360 | 23,909,245 | D001672:Biocompatible Materials; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012886:Skull; D012887:Skull Fractures; D016896:Treatment Outcome; D014945:Wound Healing | Journal of neurosurgery | 2,014 | D001672:Biocompatible Materials |
Development and implementation experience of a learning healthcare system for facility based newborn care in low resource settings: The Neotree. | Introduction
Improving peri- and postnatal facility-based care in low-resource settings (LRS) could save over 6000 babies' lives per day. Most of the annual 2.4 million neonatal deaths and 2 million stillbirths occur in healthcare facilities in LRS and are preventable through the implementation of cost-effective, simpl... | 10.1002/lrh2.10310 | 36,654,803 | Learning health systems | 2,023 | ||
Cutaneous larva migrans in the northeastern US. | Cutaneous larva migrans (CLM) is a dermo-epidermal parasitic infection with a disproportionate incidence in developing countries, particularly in, and near tropical areas. It is characterized by erythematous, twisting, and linear plaques that can migrate to adjacent skin. Herein, we present an otherwise healthy 45-year... | 10.5070/D329461906 | 37,921,817 | D006801:Humans; D005260:Female; D008875:Middle Aged; D007815:Larva Migrans; D007559:Ivermectin; D012867:Skin; D004817:Epidermis; D005076:Exanthema | Dermatology online journal | 2,023 | D007559:Ivermectin |
Comparison of the Xpert CARBA-R Test and Phenotypical Tests for Detection of Carbapenemases Types in Multidrug Resistant K. pneumoniae Isolates. | BACKGROUND
The objective of this study is to evaluate the performance of the Xpert CARBA-R Test and the phenotyping confirmation tests (MHT, CIM, Mastdiscs, and Carba NP) for the detection of carbapenemases in multidrug resistant (MDR) Klebsiella pneumoniae isolates.
METHODS
A total of 68 MDR K. pneumoniae isolates i... | 10.7754/Clin.Lab.2019.190137 | 31,414,758 | D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007711:Klebsiella pneumoniae; D008826:Microbial Sensitivity Tests; D015203:Reproducibility of Results; D001618:beta-Lactamases | Clinical laboratory | 2,019 | D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase |
Changes in mental health during the COVID-19 crisis in Romania: A repeated cross-section study based on the measurement of subjective perceptions and experiences. | The coronavirus 2019 (COVID-19) pandemic has caused dramatic changes in the daily lives of Romanians, affecting their mental health. The COVID-19 pandemic has evolved at three significant peaks, which sequentially occurred on: April 29, 2020; September 18, 2020; and the third wave registered the highest severity on Nov... | 10.1177/00368504211025873 | 34,143,706 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001007:Anxiety; D000086382:COVID-19; D003430:Cross-Sectional Studies; D003863:Depression; D004522:Educational Status; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008347:Manifest Anxiety Scale; D008603:Mental Health; D0088... | Science progress | 2,021 | |
Sleep Bruxism and SDB in Albanian Growing Subjects: A Cross-Sectional Study. | Background: The aim of this study was to evaluate a possible correlation between sleep bruxism and risk factors of developing obstructive sleep apnea syndrome (OSAS) in a sample of growing subjects and to assess parental awareness about sleep bruxism in their children. Methods: The sample was composed of 310 subjects (... | 10.3390/dj9030025 | 33,673,649 | Dentistry journal | 2,021 | ||
A lesion of the patella: An unexpected location of Rosai-Dorfman disease: A case report. | INTRODUCTION
Primary osseous Rosai-Dorfman disease (RDD) is a rare and benign disease that can pose diagnosis challenges.
PRESENTATION OF THE CASE
We report the case of a 29-year-old woman who presented with pain in her left patellar region for the past 6 months with no other clinical sign especially no lymphadenopat... | 10.1016/j.ijscr.2022.107510 | 35,985,119 | International journal of surgery case reports | 2,022 | ||
Speckle Tracking Echocardiography in Patients with Ankylosing Spondylitis and Evaluation of Subclinical Involvement. | Introduction
Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily affecting the spine and the joints. It also affects multiple organs in the body including the cardiovascular system. Left ventricular (LV) global longitudinal strain (GLS) is a good measure for recognizing subclinical myocardial dysf... | 10.31138/mjr.20230724.ei | 37,941,872 | Mediterranean journal of rheumatology | 2,023 | ||
An analytical complete model of root pressure generation: Theoretical bases for studying hydraulics of bamboo. | To better understand the dynamics and functional roles of root pressure, we represent a novel and the first complete analytical model for root pressure, which can be applied to complex roots/shoots. The osmotic volume of a single root is equal to that of the vessel lumen in fine roots and adjacent apoplastic spaces. Wa... | 10.1111/pce.14730 | 37,807,644 | D018517:Plant Roots; D001692:Biological Transport; D014867:Water; D004058:Diffusion; D010944:Plants; D012987:Soil | Plant, cell & environment | 2,024 | D014867:Water; D012987:Soil |
Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling. | The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight. This study aimed to compare the accuracy of two physiologically based pharmacokinetic (PBPK) Vss prediction methods in neonates (Pouli... | 10.3390/pharmaceutics15092348 | 37,765,316 | Pharmaceutics | 2,023 | ||
GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. | We used an immunoperoxidase procedure to examine the tissue distribution of the platelet alpha-granule membrane protein, GMP-140. In addition to its presence in megakaryocytes and platelets, GMP-140 antigen was found in vascular endothelial cells of diverse human organs, but it was not detected in other types of secret... | 10.1172/JCI114175 | 2,472,431 | D002478:Cells, Cultured; D003594:Cytoplasmic Granules; D004591:Electrophoresis, Polyacrylamide Gel; D004730:Endothelium, Vascular; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007150:Immunohistochemistry; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D014018:Tissue Distribution | The Journal of clinical investigation | 1,989 | D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins |
Real-time imaging of human epidermal calcium dynamics in response to point laser stimulation. | BACKGROUND
Changes of epidermal calcium ion concentration are involved in regulation of barrier homeostasis and keratinocyte differentiation. Moreover, intracellular calcium dynamics might play a role in skin sensation. But, although calcium dynamics of cultured keratinocytes in response to mechanical stresses has been... | 10.1016/j.jdermsci.2017.01.002 | 28,119,009 | D000255:Adenosine Triphosphate; D001081:Apyrase; D002118:Calcium; D020013:Calcium Signaling; D002454:Cell Differentiation; D002478:Cells, Cultured; D004817:Epidermis; D017629:Gap Junctions; D006801:Humans; D015603:Keratinocytes; D007834:Lasers; D018613:Microscopy, Confocal; D036641:Microscopy, Fluorescence, Multiphoton... | Journal of dermatological science | 2,017 | D000255:Adenosine Triphosphate; D001081:Apyrase; D002118:Calcium |
Exposure to dibutyl phthalate impairs lipid metabolism and causes inflammation via disturbing microbiota-related gut-liver axis. | Dibutyl phthalate (DBP), a kind of typical environmental pollutant, is widely used as plasticizers, and its neurotoxicity and developmental toxicity have been found in recent years. However, whether oral DBP exposure will affect the homeostasis of gut microbiota and its adverse response in liver of mammalians remain un... | 10.1093/abbs/gmaa128 | 33,167,028 | D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D000818:Animals; D001219:Aspartate Aminotransferases; D001835:Body Weight; D003106:Colon; D016207:Cytokines; D003993:Dibutyl Phthalate; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract; D007249:Inflammation; D050356:Lipid Metabolism; D008... | Acta biochimica et biophysica Sinica | 2,020 | D016207:Cytokines; D008055:Lipids; D008070:Lipopolysaccharides; D052002:NF-kappa B p50 Subunit; D012336:RNA, Ribosomal, 16S; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; C073701:Nfkb1 protein, mouse; D003993:Dibutyl Phthalate; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alka... |
Purification, crystallization and preliminary characterization of an Eph-B2/ephrin-B2 complex. | Eph receptors and their ephrin ligands are involved in various aspects of cell--cell communication during development, including those of the axon pathfinding processes in the nervous system and cell--cell interactions of the vascular endothelial cells. The recognition and binding properties of the ligand-binding domai... | 10.1107/s0907444902000264 | 11,856,847 | D000818:Animals; D003460:Crystallization; D036388:Ephrin-B2; D008565:Membrane Proteins; D051379:Mice; D011487:Protein Conformation; D020794:Receptor Protein-Tyrosine Kinases; D036183:Receptor, EphB2; D011994:Recombinant Proteins | Acta crystallographica. Section D, Biological crystallography | 2,002 | D036388:Ephrin-B2; D008565:Membrane Proteins; D011994:Recombinant Proteins; D020794:Receptor Protein-Tyrosine Kinases; D036183:Receptor, EphB2 |
[Effects of physical exercise on the parameters of carbohydrate metabolism in patients with type 2 diabetes mellitus during rehabilitative treatment]. | The evidence obtained by the authors supports literature data on a beneficial effect of muscular exercise on carbohydrate metabolism in diabetics. It is thought necessary to control sharp fluctuations of glycemia. Provided these are mild and associated with lowered insulinemia, patients with non-insulin-dependent diabe... | 1,887,293 | D000328:Adult; D001786:Blood Glucose; D050260:Carbohydrate Metabolism; D003924:Diabetes Mellitus, Type 2; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion | Sovetskaia meditsina | 1,991 | D001786:Blood Glucose | |
The method of bladder drainage in spinal cord injury patients may influence the histological changes in the mucosa of neuropathic bladder - a hypothesis. | BACKGROUND
In spinal cord injury (SCI) patients, no correlation was found between the number of bladder infections per year, the period since injury, the neurologic level of the spinal cord lesion and the histopathology of the urinary bladder mucosa. The use of chronic indwelling urethral and/or suprapubic catheters in... | 10.1186/1471-2490-2-5 | 11,980,583 | D002408:Catheters, Indwelling; D003556:Cystitis; D004322:Drainage; D006801:Humans; D008679:Metaplasia; D009092:Mucous Membrane; D011446:Prospective Studies; D013119:Spinal Cord Injuries; D001743:Urinary Bladder; D001750:Urinary Bladder, Neurogenic; D014546:Urinary Catheterization | BMC urology | 2,002 | |
Performance characterization of siemens primus linear accelerator under small monitor unit and small segments for the implementation of step-and-shoot intensity-modulated radiotherapy. | Implementation of step-and-shoot intensity-modulated radiotherapy (IMRT) needs careful understanding of the accelerator start-up characteristic to ensure accurate and precise delivery of radiation dose to patient. The dosimetric characteristic of a Siemens Primus linear accelerator (LA) which delivers 6 and 18 MV x-ray... | 10.4103/0971-6203.29197 | 21,206,643 | Journal of medical physics | 2,006 | ||
Tricuspid annular plane systolic excursion for the evaluation of right ventricular function in functional cardiac CT compared to MRI. | AIM
To compare ejection fraction estimated by tricuspid annular plane systolic excursion (TAPSE) using cardiac computed tomography (CT) and cardiac magnetic resonance imaging (MRI) to the non-invasive reference standard, volumetric quantification of right ventricular ejection fraction (RVEF) by cardiac magnetic resonan... | 10.1016/j.crad.2021.02.018 | 33,879,320 | D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D018497:Ventricular Dysfunction, Right; D016278:Ventricular Fu... | Clinical radiology | 2,021 | |
Bilirubin binding capacity of albumin isolated from cord-blood serum is less than that from serum of adults. | As estimated by Sephadex gel filtration, the bilirubin binding capacity of albumin isolated from cord-blood serum by ion-exchange chromatography is less than that of albumin isolated from serum of adults. Albumin isolated from cord-blood serum showed increased bilirubin binding as compared with the albumin in the nativ... | 7,371,151 | D000328:Adult; D000367:Age Factors; D001663:Bilirubin; D002852:Chromatography, Ion Exchange; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D011485:Protein Binding; D012709:Serum Albumin | Clinical chemistry | 1,980 | D012709:Serum Albumin; D001663:Bilirubin | |
Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice. | Recent large-scale sequence analyses revealed 'signature' amino acids at specific positions in viral proteins that distinguish human influenza viruses from avian viruses. To determine the role of these host lineage-specific amino acids in the pathogenicity of H5N1 avian influenza viruses, we generated mutant viruses po... | 10.1099/vir.0.018143-0 | 20,016,035 | D000596:Amino Acids; D000818:Animals; D001921:Brain; D002460:Cell Line; D004285:Dogs; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype; D007928:Lethal Dose 50; D008168:Lung; D051379:Mice; D016297:Mutagenesis, Site-Directed; D009296:Nasal Cavity; D019590:Nucleocapsid Proteins; D009976:Orthomyxoviridae Infections;... | The Journal of general virology | 2,010 | D000596:Amino Acids; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; C061290:PA protein, influenza viruses; C057027:PB2 protein, Influenzavirus A; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins; D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase |
Mucocutaneous manifestations of Dengue fever. | Dengue viral infection is a cause of considerable morbidity and mortality and may be associated with a variety of mucocutaneous manifestations that may provide important early clues to the diagnosis of this condition. Cutaneous and mucosal findings like confluent erythema, morbilliform eruptions, and hemorrhagic lesion... | 10.4103/0019-5154.60359 | 20,418,984 | Indian journal of dermatology | 2,010 | ||
Coaxial electrospun zein nanofibrous membrane for sustained release. | Zein nanofibrous membranes for sustained release have been prepared by coaxial electrospinning. Core-sheath structure has been successfully fabricated using zein as both the core and sheath component. Impact of solvent and solution concentration on the morphology of the resulting fibers was investigated. Allyltriphenyl... | 10.1080/09205063.2013.808960 | 23,782,228 | D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004926:Escherichia coli; D008567:Membranes, Artificial; D057139:Nanofibers; D036103:Nanotechnology; D013211:Staphylococcus aureus; D015028:Zein | Journal of biomaterials science. Polymer edition | 2,013 | D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008567:Membranes, Artificial; D015028:Zein |
Simulating laparoscopic renal hilar vessel injuries: preliminary evaluation of a novel surgical training model for residents. | INTRODUCTION
Many surgical training programs utilize simulation-based strategies for instruction and assessment of laparoscopic skills. While the use of inanimate, animate, and virtual-reality simulation for basic or procedural skills training has been well described, the use of simulation for the purpose of training s... | 10.1089/end.2011.0432 | 22,192,098 | D003198:Computer Simulation; D006801:Humans; D007396:Internship and Residency; D007668:Kidney; D010535:Laparoscopy; D008953:Models, Anatomic; D017145:Models, Educational; D009392:Nephrectomy; D013647:Task Performance and Analysis | Journal of endourology | 2,012 | |
Intravenous pulse cyclophosphamide--a new regime for steroid resistant focal segmental glomerulosclerosis. | OBJECTIVE
A prospective study was conducted to evaluate the role of intravenous pulse cyclophosphamide (IVCP) infusions in the management of children with steroid resistant (SR) idiopathic focal segmental glomerulosclerosis (FSGS).
METHODS
The study group comprised of 20 consecutive children with idiopathic nephrotic... | 10,745,408 | D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental; D006801:Humans; D007166:Immunosuppressive Agents; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D020551:Pulse Therapy, Drug | Indian pediatrics | 2,000 | D007166:Immunosuppressive Agents; D003520:Cyclophosphamide | |
Analysis of graft survival in a trial of stem cell transplant in ALS. | OBJECTIVE
The first US Food and Drug Administration-approved clinical trial to treat amyotrophic lateral sclerosis (ALS) with neural stem cell-based therapy is in progress. The goal of the current study was to identify and assess the survival of human spinal cord-derived neural stem cells (HSSCs) transplanted into the ... | 10.1002/acn3.134 | 25,540,804 | Annals of clinical and translational neurology | 2,014 | ||
Simplified projection of EEG dipole sources onto human brain anatomy. | This study was aimed at determining an easy way to project dipole modelling results onto brain anatomy. This simplified projection is based on the estimation of the mean location of the centre of the dipole sphere according to internal brain landmarks. The mean values for the centre location were calculated from ten ep... | 10.1016/S0987-7053(99)80040-9 | 10,093,817 | D001921:Brain; D001931:Brain Mapping; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D006801:Humans; D008279:Magnetic Resonance Imaging; D015203:Reproducibility of Results | Neurophysiologie clinique = Clinical neurophysiology | 1,999 | |
Thymus histogenesis in C3H mice. | The histogenesis of the mouse thymus was studied by means of light and electron microscopy in an attempt to clarify the simultaneous development of stromal and lymphoid cell populations. On the twelfth day of embryonic life, the thymus primordium was composed principally of undifferentiated epithelial cells and some ly... | 3,266,905 | D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D004847:Epithelial Cells; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012686:Septal Nuclei; D013601:T-Lymphocytes; D013950:Thymus Gland | Thymus | 1,988 | ||
[Nephrotic syndrome and protein metabolism]. | The adult protein turn-over daily affects 250 grammes, which is equivalent to four times the average daily protein intake. Regulation of synthesis and catabolism appears to occur by independent ways. These systems are altered during the nephrotic syndrome and ultimately lead to a loss of total body nitrogen and a risk ... | 8,927,206 | D000328:Adult; D000418:Albumins; D004044:Dietary Proteins; D006801:Humans; D009124:Muscle Proteins; D009404:Nephrotic Syndrome; D011506:Proteins; D011507:Proteinuria | Nephrologie | 1,996 | D000418:Albumins; D004044:Dietary Proteins; D009124:Muscle Proteins; D011506:Proteins | |
Antibiotic treatment can delay ejaculation in patients with premature ejaculation and chronic bacterial prostatitis. | INTRODUCTION
Premature ejaculation (PE) is regarded as the most common male sexual disorder. Previous studies reported that prostatic inflammation was highly prevalent in PE. However, the effect of antibiotic treatment of cases with PE and chronic prostatitis has not been extensively investigated.
AIM
To examine the ... | 10.1111/j.1743-6109.2006.00243.x | 17,367,444 | D000328:Adult; D000900:Anti-Bacterial Agents; D002908:Chronic Disease; D003075:Coitus; D004542:Ejaculation; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011472:Prostatitis; D012735:Sexual Dysfunction, Physiological; D016896:Treatment Outcome | The journal of sexual medicine | 2,007 | D000900:Anti-Bacterial Agents |
Prosencephalic neural folds give rise to neural crest cells in the Australian lungfish, Neoceratodus forsteri. | Here we present a fate map of the prosencephalic neural fold (PNF) for the Australian lungfish. The experimental procedures were carried out on lungfish embryos at Kemp's stage 24 using three different approaches. First, either medial PNF (MPNF) or lateral PNF (LPNF) were ablated and the embryos cultured until they rea... | 10.1002/jez.b.21248 | 19,006,202 | D000818:Animals; D005399:Fishes; D007150:Immunohistochemistry; D009432:Neural Crest; D016548:Prosencephalon | Journal of experimental zoology. Part B, Molecular and developmental evolution | 2,009 | |
Satisfaction with civilian family medicine residency training: Perspectives from serving general duty medical officers in the Canadian Armed Forces. | OBJECTIVE
To evaluate satisfaction with civilian residency training programs among serving general duty medical officers within the Canadian Armed Forces.
DESIGN
A 23-item, cross-sectional survey face-validated by the office of the Surgeon General of the Canadian Armed Forces.
SETTING
Canada.
PARTICIPANTS
General... | 27,629,689 | D000328:Adult; D002170:Canada; D003430:Cross-Sectional Studies; D005194:Family Practice; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007396:Internship and Residency; D007588:Job Satisfaction; D008297:Male; D008875:Middle Aged; D008889:Military Personnel | Canadian family physician Medecin de famille canadien | 2,016 | ||
Signifying the Effect of Relational and Experiential Cognitive Styles on Entrepreneurial Behavior: A Mediated Moderated Model. | This study investigates the influence of rational and experiential cognitive styles on entrepreneurial behavior. Specifically, the moderating role of entrepreneurial intention and informal learning has been contemplated. Data has been accumulated from 320 undergraduate students of universities situated in Pakistan. Sta... | 10.3389/fpsyg.2021.762403 | 34,721,243 | Frontiers in psychology | 2,021 | ||
Effect of dexamethasone on lymphocyte subpopulations in premature infants with bronchopulmonary dysplasia. | OBJECTIVE
This study was designed to determine the effect of dexamethasone treatment on peripheral blood lymphocyte counts and subpopulations in premature infants with bronchopulmonary dysplasia (BPD).
STUDY DESIGN
Peripheral blood lymphocyte subpopulations in 12 premature infants with BPD were analyzed before treatm... | 10.1038/sj.jp.7200201 | 10,685,255 | D001402:B-Lymphocytes; D001997:Bronchopulmonary Dysplasia; D016516:CD4-CD8 Ratio; D003907:Dexamethasone; D005938:Glucocorticoids; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007958:Leukocyte Count; D016131:Lymphocyte Subsets; D009504:Neutrophils; D013601:T-Lymphocytes; D015300:Ventilator Weanin... | Journal of perinatology : official journal of the California Perinatal Association | 1,999 | D005938:Glucocorticoids; D003907:Dexamethasone |
Effects of reversible noise exposure on the suppression tuning of rabbit distortion-product otoacoustic emissions. | Distortion-product otoacoustic emissions (DPOAEs) at 2f1-f2 can be suppressed by the introduction of a third "suppressor" tone. Plotting the suppression of the DPOAE level against the changing frequency and level of the suppressor produces frequency-tuning functions referred to as suppression tuning curves (STCs). The ... | 10.1121/1.1419094 | 11,831,802 | D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea; D003056:Cochlear Nerve; D009622:Noise; D017084:Otoacoustic Emissions, Spontaneous; D011817:Rabbits; D013997:Time Factors | The Journal of the Acoustical Society of America | 2,002 | |
Several new approaches to improvement of alpha interferon therapy in chronic myelogenous leukaemia. | Several basic experimental and clinical studies were carried out in an attempt to improve the efficacy of alpha interferon therapy for chronic myelogenous leukaemia (CML). First, the combined use of hydroxyurea (HU) and interferon (500-1000 mg daily) in interferon-resistant cases facilitated maintenance of reduced leuc... | 10.1016/0277-5379(91)90559-v | 1,799,469 | D000818:Animals; D003131:Combined Modality Therapy; D015316:Genetic Therapy; D006801:Humans; D006918:Hydroxyurea; D016898:Interferon-alpha; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D008727:Methotrexate; D051379:Mice; D012333:RNA, Messenger; D012334:RNA, Neoplasm | European journal of cancer (Oxford, England : 1990) | 1,991 | D016898:Interferon-alpha; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D006918:Hydroxyurea; D008727:Methotrexate |
Effects of thyrotropin-releasing hormone on GABAergic synaptic transmission of the rat hippocampus. | The effect of thyrotropin-releasing hormone (TRH), a neuropeptide physiologically present in the mammalian hippocampus, on spontaneous, miniature and evoked GABAergic postsynaptic currents was investigated using whole-cell patch-clamp recording from pyramidal cells and interneurons of the rat hippocampal thin slice pre... | 10.1111/j.1460-9568.1996.tb01298.x | 8,752,600 | D000818:Animals; D005071:Evoked Potentials; D006624:Hippocampus; D007395:Interneurons; D009479:Neuropeptides; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission; D013973:Thyrotropin-Releasing Hormone | The European journal of neuroscience | 1,996 | D009479:Neuropeptides; D013973:Thyrotropin-Releasing Hormone |
Issues for the next generation of health care cost analyses. | BACKGROUND
Given the characteristics of health care expenditure/cost data-a mass of observations at zero, and skewed positive expenditures, various alternative estimators have been developed that can address the analytical issues these characteristics raise. The field continues to develop new approaches and to evaluate... | 10.1097/MLR.0b013e31819c94a1 | 19,536,022 | D003365:Costs and Cost Analysis; D005069:Evaluation Studies as Topic; D017048:Health Care Costs; D017059:Models, Econometric; D017063:Outcome Assessment, Health Care; D012044:Regression Analysis; D018709:Statistics, Nonparametric | Medical care | 2,009 | |
A Preprocessing Tool for Enhanced Ion Mobility-Mass Spectrometry-Based Omics Workflows. | The ability to improve the data quality of ion mobility-mass spectrometry (IM-MS) measurements is of great importance for enabling modular and efficient computational workflows and gaining better qualitative and quantitative insights from complex biological and environmental samples. We developed the PNNL PreProcessor,... | 10.1021/acs.jproteome.1c00425 | 34,382,401 | D002853:Chromatography, Liquid; D006801:Humans; D000075663:Ion Mobility Spectrometry; D007477:Ions; D008055:Lipids; D013058:Mass Spectrometry; D057188:Workflow | Journal of proteome research | 2,022 | D007477:Ions; D008055:Lipids |
Using the Beck Depression Inventory to Assess Anhedonia: A Scale Validation Study. | Anhedonia is central to several psychological disorders and a frequent target of psychosocial and pharmacological treatments. We evaluated the psychometric properties of two widely used anhedonia measures derived from the Beck Depression Inventory: a 3-item (BDI-Anh3) and a 4-item version (BDI-Anh4). We evaluated these... | 10.1177/10731911231164628 | 37,039,528 | Assessment | 2,023 | ||
Promising Role of Melatonin as Neuroprotectant in Neurodegenerative Pathology. | Melatonin treatment showed a potent neuroprotective action in experimental models and in clinical studies. However, the entire disease prevention is not observed with melatonin treatment. Therefore, findings have suggested its future use in combination therapies for neurological diseases. Several studies have showed it... | 10.1007/s12035-014-8865-8 | 25,159,482 | D000818:Animals; D000975:Antioxidants; D017209:Apoptosis; D006801:Humans; D008550:Melatonin; D008954:Models, Biological; D019636:Neurodegenerative Diseases; D018696:Neuroprotective Agents | Molecular neurobiology | 2,015 | D000975:Antioxidants; D018696:Neuroprotective Agents; D008550:Melatonin |
Hierarchical Modeling and Differential Expression Analysis for RNA-seq Experiments with Inbred and Hybrid Genotypes. | The performance of inbred and hybrid genotypes is of interest in plant breeding and genetics. High-throughput sequencing of RNA (RNA-seq) has proven to be a useful tool in the study of the molecular genetic responses of inbreds and hybrids to environmental stresses. Commonly used experimental designs and sequencing met... | 10.1007/s13253-015-0232-3 | 27,110,090 | Journal of agricultural, biological, and environmental statistics | 2,015 |
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