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LncRNA-SNHG7 interferes with miR-34a to de-sensitize gastric cancer cells to cisplatin. | Gastric cancer (GC) remains poor prognosis and survival issues due to the resistance of chemotherapies, such as cisplatin. The long non-coding RNA small nucleolar RNA host gene 7 (lncRNA-SNHG7) is known as an oncogenic molecule in diverse cancers. Here, we demonstrate that SNHG7 was significantly upregulated in gastric... | 10.3233/CBM-201621 | 33,074,217 | D000970:Antineoplastic Agents; D002945:Cisplatin; D019008:Drug Resistance, Neoplasm; D006801:Humans; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D013274:Stomach Neoplasms | Cancer biomarkers : section A of Disease markers | 2,021 | D000970:Antineoplastic Agents; C522425:MIRN34 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D002945:Cisplatin |
Computer-assisted learning versus a lecture and feedback seminar for teaching a basic surgical technical skill. | BACKGROUND
Rapid improvements in computer technology allow us to consider the use of computer-assisted learning (CAL) for teaching technical skills in surgical training. The objective of this study was to compare in a prospective, randomized fashion, CAL with a lecture and feedback seminar (LFS) for the purpose of teac... | 10.1016/s0002-9610(98)00087-7 | 9,645,783 | D003194:Computer-Assisted Instruction; D004504:Education, Medical, Undergraduate; D013502:General Surgery; D006801:Humans; D011446:Prospective Studies; D011897:Random Allocation; D013536:Suture Techniques; D013663:Teaching; D014743:Videotape Recording | American journal of surgery | 1,998 | |
Functional Additive Mixed Models. | We propose an extensive framework for additive regression models for correlated functional responses, allowing for multiple partially nested or crossed functional random effects with flexible correlation structures for, e.g., spatial, temporal, or longitudinal functional data. Additionally, our framework includes linea... | 10.1080/10618600.2014.901914 | 26,347,592 | Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America | 2,015 | ||
Immunity provided by haemorrhagic septicaemia-subunit vaccine in ruminants. | A subunit vaccine against haemorrhagic septicaemia (HS), the principal killer disease in ruminants, especially cattle and carabao, in the Philippines, has been developed. Using capsules of Pasteurella multocida Group B as an active component of the vaccine, it gave solid protection against challenge with live organism ... | 9,554,285 | D000818:Animals; D000911:Antibodies, Monoclonal; D001428:Bacterial Vaccines; D002417:Cattle; D002418:Cattle Diseases; D004353:Drug Evaluation, Preclinical; D004797:Enzyme-Linked Immunosorbent Assay; D006483:Hemorrhagic Septicemia; D008297:Male; D051379:Mice; D016979:Pasteurella multocida; D010679:Philippines; D012418:R... | Developments in biological standardization | 1,998 | D000911:Antibodies, Monoclonal; D001428:Bacterial Vaccines; D014614:Vaccines, Synthetic | |
CoMn2O4 Catalyst Prepared Using the Sol-Gel Method for the Activation of Peroxymonosulfate and Degradation of UV Filter 2-Phenylbenzimidazole-5-sulfonic Acid (PBSA). | In this study, a bimetallic oxide catalyst of cobalt-manganese (CoMn2O4) was synthesized using the sol-gel method, and it was then characterized using a variety of techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) spectroscopy, X-ray photoelectron spe... | 10.3390/nano9050774 | 31,137,519 | Nanomaterials (Basel, Switzerland) | 2,019 | ||
The effect of dithiothreitol on the activity of tityustoxin from the scorpion Tityus serrulatus venom. | The acetylcholine (ACh) liberating effect on rat brain slices of tityustoxin, an alpha toxin from the scorpion Tityus serrulatus venom, was measured in the absence and presence of dithiothreitol (DTT). The rate of net ACh liberation by toxin concentrations of 2 nmol in 5 ml of organ bath, was 7.5 +/- 0.09 nmol g-1 min-... | 10.1016/0378-4274(94)90203-8 | 8,140,595 | D000109:Acetylcholine; D000818:Animals; D001921:Brain; D004229:Dithiothreitol; D005260:Female; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009498:Neurotoxins; D010179:Pancreas; D051381:Rats; D012604:Scorpion Veno... | Toxicology letters | 1,994 | D009498:Neurotoxins; D012604:Scorpion Venoms; C003609:tityustoxin; D000109:Acetylcholine; D004229:Dithiothreitol |
Detection of the effects of triclosan (TCS) on the metabolism of VOCs in HepG2 cells by SPI-TOFMS. | Volatile organic compounds (VOCs) emitted by organisms and cell metabolism have demonstrated great physiological and pathological values. At present, there is a great interest in the study of volatile metabolome to determine whether VOCs can serve as potential diagnostic biomarkers. In view of the sensitivity of VOCs t... | 10.1088/1752-7163/ab9ab1 | 32,512,549 | D002470:Cell Survival; D005978:Glutathione; D056945:Hep G2 Cells; D006801:Humans; D013058:Mass Spectrometry; D055442:Metabolome; D008970:Molecular Weight; D015203:Reproducibility of Results; D014260:Triclosan; D055549:Volatile Organic Compounds | Journal of breath research | 2,020 | D055549:Volatile Organic Compounds; D014260:Triclosan; D005978:Glutathione |
The role of burn camp in the recovery of young people from burn injury: A qualitative study using long-term follow-up interviews with parents and participants. | BACKGROUND
Children and adolescents recovering from burn injury are at heightened risk of psychosocial problems. An integrative form of psychosocial intervention is burn camp. However, evidence about burn camp effectiveness is equivocal.
OBJECTIVES
This study examined the role of therapeutic camp experiences in the r... | 10.1016/j.burns.2021.09.020 | 34,607,728 | D000293:Adolescent; D002056:Burns; D002165:Camping; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D010290:Parents; D036301:Qualitative Research; D012189:Retrospective Studies; D012649:Self Concept | Burns : journal of the International Society for Burn Injuries | 2,022 | |
Single-shot spatially modulated Stokes polarimeter based on a GRIN lens. | A new polarimeter for the simultaneous measurement of all Stokes parameters in a single shot is presented. It consists of only a gradient index (GRIN) lens, a polarizer, an imaging lens, and a CCD, without mechanical movements, electrical signal modulation, or the division of amplitude components. This design takes adv... | 10.1364/OL.39.002656 | 24,784,070 | D004867:Equipment Design; D019544:Equipment Failure Analysis; D007909:Lenses; D010783:Photometry; D012031:Refractometry; D012815:Signal Processing, Computer-Assisted | Optics letters | 2,014 | |
[Dissections of the supraaortic arteries]. | Dissection of the cervical and intracranial vasculature is a rare but important cause of ischaemic stroke especially in young adults. In the majority of cases it affects the extracranial vessels, mostly the internal carotid artery. It might be categorized as spontaneous or traumatic, causing diverse clinical symptoms. ... | 10.18071/isz.69.0292 | 29,638,092 | D000328:Adult; D000784:Aortic Dissection; D002343:Carotid Artery, Internal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke | Ideggyogyaszati szemle | 2,016 | |
A bio-relevant supramolecular Co(ii)-complex for selective fluorescence sensing of μM range inorganic As(iii) in aqueous medium and its intracellular tracking in bacterial systems. | A novel Co(ii)-complex {i.e. [Co(n-BuM)(DPA)(H2O)2]·H2O} [n-BuMH2 = n-butylmalonic acid and DPA = 2,2'-dipyridylamine] was synthesized. The supramolecular feature, i.e. a metal coordinated and free guest water mediated hydrogen-bonding interaction assisted supramolecular ππ assembly, has been observed in the crystal st... | 10.1039/c8dt04127j | 30,860,539 | D001152:Arsenicals; D001407:Bacillus; D015374:Biosensing Techniques; D002101:Cacodylic Acid; D003035:Cobalt; D056831:Coordination Complexes; D005456:Fluorescent Dyes; D006860:Hydrogen Bonding; D057054:Molecular Imaging; D061848:Optical Imaging; D014867:Water | Dalton transactions (Cambridge, England : 2003) | 2,019 | D001152:Arsenicals; D056831:Coordination Complexes; D005456:Fluorescent Dyes; D014867:Water; D003035:Cobalt; D002101:Cacodylic Acid |
Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance. | The overexpression of P-glycoprotein plays an important role in the process of multidrug resistance (MDR). P-gp inhibitors are one of the effective strategies to reverse tumor MDR. Novel P-gp inhibitors with phthalazinone scaffolds were designed, synthesized and evaluated. Compound 26 was found to be the most promising... | 10.1016/j.bioorg.2019.01.039 | 30,710,850 | D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000903:Antibiotics, Antineoplastic; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin; D015195:Drug Design; D018432:Drug Resistance, Multiple; D019008:Drug Resistanc... | Bioorganic chemistry | 2,019 | D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000903:Antibiotics, Antineoplastic; D007546:Isoquinolines; D010793:Phthalazines; D004317:Doxorubicin |
[Genetic monitoring of human population exposed to chemical and radiation hazards]. | It is impossible to protect human heredity from the ecological consequences of environmental pollution if there is no permanent control of hereditary variability in human populations, i.e. genetic monitoring. One of the urgent problems in genetic monitoring planning is the magnitude of representative samples necessary ... | 1,384,870 | D000014:Abnormalities, Drug-Induced; D000016:Abnormalities, Radiation-Induced; D000059:Accidents; D000328:Adult; D002869:Chromosome Aberrations; D003582:Cytogenetics; D004785:Environmental Pollutants; D005260:Female; D005821:Genetic Techniques; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged;... | Vestnik Rossiiskoi akademii meditsinskikh nauk | 1,992 | D004785:Environmental Pollutants; D009153:Mutagens | |
A gamma and G gamma globin chain synthesis in BFU-E colonies from adult, newborn, and fetal subjects and from thalassemic patients. | The G gamma and A gamma content of Hb F produced in cultures of BFU-Es from the blood of normal fetuses, neonates, and adults was determined. The results show that erythroid progenitors produce A gamma and G gamma chains in a ratio characteristic of their ontogenic stage. The analysis of the G gamma/A gamma ratio in cu... | 6,158,541 | D000328:Adult; D004912:Erythrocytes; D005319:Fetal Hemoglobin; D005333:Fetus; D006412:Hematopoietic Stem Cells; D006801:Humans; D007231:Infant, Newborn; D013789:Thalassemia | The Journal of laboratory and clinical medicine | 1,980 | D005319:Fetal Hemoglobin | |
Alexithymia and Autism Spectrum Disorder: A Complex Relationship. | Alexithymia is a personality construct characterized by altered emotional awareness which has been gaining diagnostic prevalence in a range of neuropsychiatric disorders, with notably high rates of overlap with autism spectrum disorder (ASD). However, the nature of its role in ASD symptomatology remains elusive. Here, ... | 10.3389/fpsyg.2018.01196 | 30,065,681 | Frontiers in psychology | 2,018 | ||
Neurochemical characteristics of rats distinguished as benzodiazepine responders and non-responders in a new conflict test. | Using a new rat conflict test it was found that 30% of the subjects failed to respond to benzodiazepines and other anxiolytic agents. This value is similar to that reported using more classical procedures such as the Geller-Seifter and Vogel conflict tests. Biochemical analysis of various brain regions from responder (... | 10.1016/0024-3205(84)90053-5 | 6,146,084 | D000818:Animals; D014151:Anti-Anxiety Agents; D001921:Brain; D002707:Chlordiazepoxide; D003220:Conflict, Psychological; D003975:Diazepam; D004361:Drug Tolerance; D006624:Hippocampus; D008297:Male; D011678:Punishment; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin; D005680:gamma-Aminobutyric Acid | Life sciences | 1,984 | D014151:Anti-Anxiety Agents; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D002707:Chlordiazepoxide; D003975:Diazepam |
A taxonomic note on the helicoid land snail genus Traumatophora (Eupulmonata, Camaenidae). | Traumatophoratriscalpta (Martens, 1875) is reported for the first time from the Tianmushan Mountains, Zhejiang Province, and its morpho-anatomy is described based on this new material. The genus Traumatophora is redefined on the basis of both shell and genital anatomy of its type species. The presence of the dart appar... | 10.3897/zookeys.835.32697 | 31,046,027 | ZooKeys | 2,019 | ||
No evidence of in vitro and in vivo porcine endogenous retrovirus infection after plasmapheresis through the AMC-bioartificial liver. | BACKGROUND
Currently a number of bioartificial livers (BAL) based on porcine liver cells have been developed as a treatment to bridge acute liver failure patients to orthotopic liver transplantation or liver regeneration. These xenotransplantation related treatments hold the risk of infection of treated patients by por... | 10.1111/j.1399-3089.2005.00226.x | 15,943,777 | D000328:Adult; D000818:Animals; D002460:Cell Line; D020077:Endogenous Retroviruses; D005500:Follow-Up Studies; D006801:Humans; D019164:Liver, Artificial; D008875:Middle Aged; D010956:Plasmapheresis; D012192:Retroviridae Infections; D013552:Swine | Xenotransplantation | 2,005 | |
Two-dimensional nuclear magnetic resonance spectroscopy. | Great spectral simplification can be obtained by spreading the conventional one-dimensional nuclear magnetic resonance (NMR) spectrum in two independent frequency dimensions. This so-called two-dimensional NMR spectroscopy removes spectral overlap, facilitates spectral assignment, and provides a wealth of additional in... | 10.1126/science.3518060 | 3,518,060 | D002244:Carbon; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy; D009113:Muramidase; D009584:Nitrogen; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides; D009875:Operator Regions, Genetic; D011487:Protein Conformation | Science (New York, N.Y.) | 1,986 | D009843:Oligoribonucleotides; D002244:Carbon; D006859:Hydrogen; D009113:Muramidase; D009584:Nitrogen |
Delimitation of the period of sensitivity to the cataractogenic action of selenite in rats. | The period when selenite is able to induce cataracts begins on the 2nd and ends on the 17th day of postnatal life. Higher doses of selenite do not change the beginning of the cataractogenic period but may induce rare cataracts (up to 17%) when given on the 18th and 19th day of life. The lethal effect of selenite, which... | 6,622,557 | D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002386:Cataract; D005333:Fetus; D051381:Rats; D011919:Rats, Inbred Strains; D020887:Selenious Acid; D012643:Selenium | Physiologia Bohemoslovaca | 1,983 | D020887:Selenious Acid; D012643:Selenium | |
Serum cytokine changes in Turkish children infected with Giardia lamblia with and without allergy: Effect of metronidazole treatment. | The present report is a case control study aimed to determine the levels of cytokines and other parameters in the sera of allergy-complicated and uncomplicated giardiasic children before and after metronidazole treatment. The study included a total of 126 subjects; 52 giardiasic children, 34 allergy-complicated giardia... | 10.1016/j.actatropica.2005.05.006 | 15,979,046 | D000293:Adolescent; D000981:Antiprotozoal Agents; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016207:Cytokines; D005260:Female; D005873:Giardiasis; D006801:Humans; D006967:Hypersensitivity; D008297:Male; D008795:Metronidazole; D014421:Turkey | Acta tropica | 2,005 | D000981:Antiprotozoal Agents; D016207:Cytokines; D008795:Metronidazole |
The effect of pre-analytical variables on light transmittance aggregometry in citrated platelet-rich plasma from healthy subjects. | BACKGROUND
Although light transmittance aggregometry is considered the gold standard for platelet function testing, it is poorly standardized. The effect of several pre-analytical variables on this assay was investigated.
METHODS
Light transmittance aggregometry was performed with an automated coagulation analyzer us... | 10.1515/CCLM.2010.285 | 20,618,093 | D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D006801:Humans; D010976:Platelet Count; D010979:Platelet Function Tests; D053657:Platelet-Rich Plasma; D012016:Reference Values; D012680:Sensitivity and Specificity | Clinical chemistry and laboratory medicine | 2,010 | |
Clinical management of a complicated crown-root fracture: a case report. | This report describes the clinical procedures involved in the treatment of a complicated crown-root fracture in the maxillary left central incisor with a wide open apex of a 10-year-old male patient, due to fall from his own height. Post-trauma treatment comprised cervical pulpotomy and adhesive tooth fragment reattach... | 21,915,526 | D056624:Apexification; D002126:Calcium Hydroxide; D002648:Child; D001840:Dental Bonding; D003790:Dental Pulp Necrosis; D003793:Dental Restoration, Permanent; D005500:Follow-Up Studies; D006801:Humans; D007180:Incisor; D008297:Male; D008437:Maxilla; D050793:Orthodontic Extrusion; D010347:Patient Care Planning; D010483:P... | Brazilian dental journal | 2,011 | D002126:Calcium Hydroxide | |
Talkative children: verbal fluency as a marker for problematic peer relationships in clinic-referred children with attention deficits. | The relationships between attention deficits, hyperactivity, neurodevelopmental performance, and problematic peer relationships were examined in 99 consecutive children (ages 9 to 11 years) referred for school problems to a clinic. Using a teachers' rating scale, 32 children with cognitive inattention and a comparison ... | 10.2466/pms.1993.76.3.943 | 8,321,611 | D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity; D002648:Child; D002653:Child Behavior Disorders; D004522:Educational Status; D005260:Female; D006801:Humans; D007805:Language Development Disorders; D008297:Male; D010379:Peer Group; D012928:Social Desirability; D012931:Social Environment; D01470... | Perceptual and motor skills | 1,993 | |
Targeted therapies: focus on a new strategy for gastrointestinal tumors. | In the last few years the knowledge of molecular oncology has led to the development of many new biological agents whose targets are extracellular or intracellular molecules involved in the main signalling pathways that play major roles in cancer development. These agents represent a new approach to gastrointestinal ma... | 10.1016/s1040-8428(03)00057-x | 12,962,900 | D019883:Alkyl and Aryl Transferases; D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D051546:Cyclooxygenase 2; D016503:Drug Delivery Systems; D066246:ErbB Receptors; D051231:Farnesyltranstransferase; D005770:Gastrointestinal Neoplasms; D006801:Humans; D007527:Isoenzymes; D061965:Matrix Metalloproteinase... | Critical reviews in oncology/hematology | 2,003 | D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D007527:Isoenzymes; D061965:Matrix Metalloproteinase Inhibitors; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstran... |
Fructan composition in adventitious tuberous roots of Viguiera discolor Baker (Asteraceae) as influenced by daylength. | Short (8-10h) photoperiods stimulated branching, flowering and enlargement of adventitious tuberous roots of Viguiera discolor Baker, a native plant of the Brazilian cerrado. Inulin was mostly accumulated in parenchyma cells associated with secondary xylem of tuberous roots. Accumulation was greater in plants grown und... | 10.1111/j.1469-8137.1991.tb01018.x | 33,874,333 | The New phytologist | 1,991 | ||
Biphasic dose-response relationship for effects of toluene inhalation on locomotor activity. | To investigate the effects of inhalation of toluene on spontaneous locomotor activity, rats were exposed to graded concentrations of toluene and locomotor activity was measured continuously before, during and after exposure. This study used a randomized, cross-over, graded-dose experimental design, with sham-exposure a... | 10.1016/0091-3057(87)90535-1 | 3,562,499 | D000818:Animals; D004305:Dose-Response Relationship, Drug; D006185:Habituation, Psychophysiologic; D008297:Male; D009043:Motor Activity; D051381:Rats; D014050:Toluene | Pharmacology, biochemistry, and behavior | 1,987 | D014050:Toluene |
Early neonatal diagnosis of long-chain 3-hydroxyacyl coenzyme a dehydrogenase and mitochondrial trifunctional protein deficiencies. | Tandem mass spectrometry (MS/MS) has been introduced in several newborn screening programs for the detection of a large number of inborn errors of metabolism, including fatty acid oxidation disorders (FAOD). Early identification and treatment of FAOD have the potential to improve outcome and may be life-saving in some ... | 10.1006/mgme.2001.3282 | 11,855,930 | D015094:3-Hydroxyacyl CoA Dehydrogenases; D000328:Adult; D005227:Fatty Acids; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008661:Metabolism, Inborn Errors; D063991:Mitochondrial Trifunctional Protein; D009097:Multienzyme Complexes; D018485:Muscle Fibers, Skeletal; D011247:Pre... | Molecular genetics and metabolism | 2,002 | D005227:Fatty Acids; D009097:Multienzyme Complexes; D015094:3-Hydroxyacyl CoA Dehydrogenases; D063991:Mitochondrial Trifunctional Protein |
Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways. | Three genes have been identified that cause, in humans, autosomally inherited parkinsonism. These are PARK2, encoding the E3 ubiquitin ligase parkin; PINK1, a mitochondrial kinase; and PARK7, which codes for the protein DJ-1. In several experimental systems, it has been shown that all three proteins impact mitochondria... | 22,951,446 | D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008928:Mitochondria; D009154:Mutation; D015513:Oncogene Proteins; D018384:Oxidative Stress; D010300:Parkinson Disease; D020734:Parkinsonian Disorders; D000071617:Protein Deglycase DJ-1;... | Cold Spring Harbor perspectives in medicine | 2,012 | D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D011494:Protein Kinases; C433927:PTEN-induced putative kinase; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1 | |
Alkaline phosphatase: the next independent predictor of the poor 90-day outcome in alcoholic hepatitis. | AIM
Determination of risk factors relevant to 90-day prognosis in AH. Comparison of the conventional prognostic models such as Maddrey's modified discriminant function (mDF) and Child-Pugh-Turcotte (CPT) score with newer ones: the Glasgow Alcoholic Hepatitis Score (GAHS); Age, Bilirubin, INR, Creatinine (ABIC) score, M... | 10.1155/2013/614081 | 24,151,614 | D000305:Adrenal Cortex Hormones; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase; D005260:Female; D006519:Hepatitis, Alcoholic; D006801:Humans; D016031:Liver Transplantation; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors; D012720:Severit... | BioMed research international | 2,013 | D000305:Adrenal Cortex Hormones; D000469:Alkaline Phosphatase |
The Importance of Using Public Health Impact Criteria to Develop Environmental Health Indicators: The Example of the Indoor Environment in New Zealand. | Developing environmental health indicators is challenging and applying a conceptual framework and indicator selection criteria may not be sufficient to prioritise potential indicators to monitor. This study developed a new approach for prioritising potential environmental health indicators, using the example of the ind... | 10.3390/ijerph15081786 | 30,127,284 | D016902:Air Pollution, Indoor; D002648:Child; D004781:Environmental Exposure; D004782:Environmental Health; D005260:Female; D006798:Housing; D006801:Humans; D009520:New Zealand; D011634:Public Health; D012959:Socioeconomic Factors | International journal of environmental research and public health | 2,018 | |
Semi-Interpenetrating Polymer Network of Hyaluronan and Chitosan Self-Healing Hydrogels for Central Nervous System Repair. | The repair of the central nervous system (CNS) is a major challenge because of the difficulty for neurons or axons to regenerate after damages. Injectable hydrogels have been developed to deliver drugs or cells for neural repair, but these hydrogels usually require conditional stimuli or additional catalysts to control... | 10.1021/acsami.0c11433 | 32,808,527 | D000818:Animals; D001672:Biocompatible Materials; D000070642:Brain Injuries, Traumatic; D049109:Cell Proliferation; D002470:Cell Survival; D002478:Cells, Cultured; D002490:Central Nervous System; D002543:Cerebral Hemorrhage; D048271:Chitosan; D004195:Disease Models, Animal; D006820:Hyaluronic Acid; D020100:Hydrogels; D... | ACS applied materials & interfaces | 2,020 | D001672:Biocompatible Materials; D020100:Hydrogels; D006820:Hyaluronic Acid; D048271:Chitosan |
Increasing Pediatric Infectious Diseases Consultation Rates for Staphylococcus aureus Bacteremia. | Introduction
Staphylococcus aureus bacteremia (SAB) in children is associated with significant mortality and morbidity, including recurrent bacteremia. Infectious disease consultation (IDC) improves SAB outcomes in adult patients. However, increasing IDC and impact for pediatric patients with SAB is not well described.... | 10.1097/pq9.0000000000000560 | 35,720,864 | Pediatric quality & safety | 2,022 | ||
E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development. | The canonical role of the transcription factor E2F is to control the expression of cell cycle genes by binding to the E2F sites in their promoters. However, the list of putative E2F target genes is extensive and includes many metabolic genes, yet the significance of E2F in controlling the expression of these genes rema... | 10.1073/pnas.2220770120 | 37,011,211 | D000818:Animals; D002843:Chromatin; D004330:Drosophila; D050684:E2F Transcription Factors; D010735:Phosphoglycerate Kinase; D011401:Promoter Regions, Genetic; D029721:Drosophila Proteins | Proceedings of the National Academy of Sciences of the United States of America | 2,023 | D002843:Chromatin; D050684:E2F Transcription Factors; D010735:Phosphoglycerate Kinase; D029721:Drosophila Proteins; C496298:E2f1 protein, Drosophila |
Avoidance behavior of Hyalella azteca in response to three common-use insecticides. | Non-target organisms in aquatic environments may experience lethal or sublethal effects following exposure to contaminants. Most protocols and regulations, however, are designed to provide protection from lethal effects and are thus based on conventional estimates of population lethality. The relative lack of reliable ... | 10.1016/j.chemosphere.2023.140492 | 37,865,201 | D000818:Animals; D007306:Insecticides; D001362:Avoidance Learning; D011722:Pyrethrins; D026023:Permethrin; D033304:Amphipoda; D014874:Water Pollutants, Chemical; D019015:Geologic Sediments | Chemosphere | 2,023 | D007306:Insecticides; C099952:bifenthrin; D011722:Pyrethrins; D026023:Permethrin; D014874:Water Pollutants, Chemical |
Molecular imprinted based microcryogels for thrombin purification. | In addition to understanding and explaining the functions of proteins, the need for low-cost, easy and efficient purification methods has been increasing in the field of protein purification, which is also important for enzyme production. In this context, an alternative approach has been developed for the purification ... | 10.1016/j.jchromb.2023.123848 | 37,582,320 | D013917:Thrombin; D055114:X-Ray Microtomography; D002846:Chromatography, Affinity; D002853:Chromatography, Liquid; D008855:Microscopy, Electron, Scanning; D000327:Adsorption; D054802:Molecular Imprinting; D017550:Spectroscopy, Fourier Transform Infrared | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences | 2,023 | D013917:Thrombin |
Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models. | TREK-1, a mechanosensitive K channel from the two-pore family (K(2)P), is involved in protective regulation of the resting potential in CNS neurons and other tissues. The structure of TREK-1 and the basis of its sensitivity to stretch and variety of lipid-soluble factors remain unknown. Using existing K channel structu... | 10.4161/chan.5.1.13906 | 21,057,213 | D000818:Animals; D003545:Cysteine; D057809:HEK293 Cells; D006801:Humans; D015640:Ion Channel Gating; D040542:Mechanotransduction, Cellular; D008564:Membrane Potentials; D008623:Mercaptoethanol; D051379:Mice; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D018408:Patch-Clamp Techniques; D024683:Potassium... | Channels (Austin, Tex.) | 2,011 | D024683:Potassium Channels, Tandem Pore Domain; C103742:potassium channel protein TREK-1; D008623:Mercaptoethanol; D003545:Cysteine |
Circulating vitamin D metabolite concentrations in childhood renal diseases. | Vitamin D metabolites were measured in children, untreated with glucocorticoids, who had renal disease. Two groups were defined in relation to endogenous creatinine clearance values: those with impaired clearance , 0 to 48 ml/min per 1.73 m2; and those with unimpaired clearance, 75 to 150 ml/min per 1.73 m2. Serum 1.25... | 10.1038/ki.1982.9 | 6,978,962 | D015650:24,25-Dihydroxyvitamin D 3; D000293:Adolescent; D002112:Calcifediol; D002117:Calcitriol; D002648:Child; D002675:Child, Preschool; D003404:Creatinine; D004100:Dihydroxycholecalciferols; D006801:Humans; D006887:Hydroxycholecalciferols; D007223:Infant; D007674:Kidney Diseases; D014807:Vitamin D | Kidney international | 1,982 | D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; D003404:Creatinine; D002117:Calcitriol; D002112:Calcifediol |
Hybrid thoracoscopic and transvenous catheter ablation of atrial fibrillation. | The hybrid approach combines an epicardial ablation with a percutaneous endocardial ablation in a single-step or sequential procedure. This study provides an overview of the hybrid procedure for the treatment of stand-alone atrial fibrillation (AF). Papers selected for this review were identified on PubMed and the fina... | 10.1093/ejcts/ezt385 | 23,904,136 | D001281:Atrial Fibrillation; D017115:Catheter Ablation; D006801:Humans; D008875:Middle Aged; D013906:Thoracoscopy | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery | 2,014 | |
Structure-guided activity restoration of the silkworm glutathione transferase Omega GSTO3-3. | Glutathione transferases (GSTs) are ubiquitous detoxification enzymes that conjugate hydrophobic xenobiotics with reduced glutathione. The silkworm Bombyx mori encodes four isoforms of GST Omega (GSTO), featured with a catalytic cysteine, except that bmGSTO3-3 has an asparagine substitution of this catalytic residue. H... | 10.1016/j.jmb.2011.07.019 | 21,816,159 | D000595:Amino Acid Sequence; D000818:Animals; D005982:Glutathione Transferase; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid | Journal of molecular biology | 2,011 | D005982:Glutathione Transferase |
Chronic selenosis in horses fed locally produced alfalfa hay. | Chronic selenosis (alkali disease) was diagnosed in horses of western Iowa, a region associated with marginal to adequate soil selenium. Two locally produced alfalfa hays (Medicago sativa L) were identified as the primary source. Difficulty in selecting diagnostic specimens to evaluate potential chronic selenosis cases... | 8,440,631 | D000821:Animal Feed; D000818:Animals; D002908:Chronic Disease; D005260:Female; D006197:Hair; D006724:Hoof and Claw; D006734:Horse Diseases; D006736:Horses; D007484:Iowa; D008297:Male; D000455:Medicago sativa; D012643:Selenium | Journal of the American Veterinary Medical Association | 1,993 | D012643:Selenium | |
Cladribine exerts an immunomodulatory effect on human and murine dendritic cells. | Cladribine is a purine nucleoside analog developed to treat lymphoid malignancies. Reported therapeutic benefits for the autoimmune disease multiple sclerosis indicate additional immunomodulatory effects beyond the well-characterized cytotoxic activity causing lymphopenia. Here, we demonstrate that cladribine reduces t... | 24,316,255 | D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D002478:Cells, Cultured; D002633:Chemotaxis; D017338:Cladribine; D016207:Cytokines; D003713:Dendritic Cells; D003911:Dextrans; D016650:Fluorescein-5-isothiocyanate; D006801:Humans; D007155:Immunologic Factors; D007963:Leuk... | International immunopharmacology | 2,014 | D016207:Cytokines; D003911:Dextrans; D007155:Immunologic Factors; C015219:fluorescein isothiocyanate dextran; D017338:Cladribine; D016650:Fluorescein-5-isothiocyanate | |
Ongoing challenges in implementation of lung cancer screening. | Lung cancer is the leading cause of cancer deaths in Europe and around the world. Although available therapies have undergone considerable development in the past decades, the five-year survival rate for lung cancer remains low. This sobering outlook results mainly from the advanced stages of cancer most patients are d... | 10.21037/tlcr-2021-1 | 34,164,282 | Translational lung cancer research | 2,021 | ||
Synthesis of a cell penetrating peptide modified superparamagnetic iron oxide and MRI detection of bladder cancer. | Bladder cancer is the most common malignancy of the urinary tract for which the accurate measurement of minimal residual disease is critical to treatment and determining prognosis. Although cystoscope examination and voided urine cytology remain the current standard of care for detecting residual disease, these approac... | 10.18632/oncotarget.13578 | 27,902,468 | D045744:Cell Line, Tumor; D057846:Cell-Penetrating Peptides; D003287:Contrast Media; D004305:Dose-Response Relationship, Drug; D005290:Ferric Compounds; D016650:Fluorescein-5-isothiocyanate; D006801:Humans; D008247:Lysosomes; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D018365:Neoplasm, Residua... | Oncotarget | 2,017 | D057846:Cell-Penetrating Peptides; D003287:Contrast Media; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D009842:Oligopeptides; C568793:R11 peptide; C000499:ferric oxide; D016650:Fluorescein-5-isothiocyanate |
Enzymatic and molecular characterization of insecticide resistance mechanisms in field populations of Aedes aegypti from Selangor, Malaysia. | BACKGROUND
Dengue is a serious public health problem worldwide, including in Selangor, Malaysia. Being an important vector of dengue virus, Aedes aegypti are subjected to control measures which rely heavily on the usage of insecticides. Evidently, insecticide resistance in Ae. aegypti, which arise from several differen... | 10.1186/s13071-019-3472-1 | 31,097,010 | D000330:Aedes; D000483:Alleles; D000818:Animals; D003715:Dengue; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase; D019476:Insect Proteins; D007305:Insecticide Resistance; D007306:Insecticides; D008294:Malathion; D008296:Malaysia; D000072138:Mosquito Vectors; D009154:Mutation; D010088:Oxidoreductases; ... | Parasites & vectors | 2,019 | D019476:Insect Proteins; D007306:Insecticides; D011722:Pyrethrins; D015222:Sodium Channels; D010088:Oxidoreductases; D005982:Glutathione Transferase; D008294:Malathion |
Valorization of cheese whey using microbial fermentations. | Cheese whey (CW), the liquid resulting from the precipitation and removal of milk casein during cheese-making, and the second cheese whey (SCW) derived from the production of cottage and ricotta cheeses are the main byproducts of dairy industry. The major constituent of CW and SCW is lactose, contributing to the high B... | 10.1007/s00253-020-10408-2 | 32,009,200 | D001628:Beverages; D001673:Biodegradation, Environmental; D001704:Biopolymers; D002611:Cheese; D005285:Fermentation; D007218:Industrial Microbiology; D000067796:Whey | Applied microbiology and biotechnology | 2,020 | D001704:Biopolymers |
Microbial sensing in the intestine. | The gut microbiota plays a key role in host health and disease, particularly through their interactions with the immune system. Intestinal homeostasis is dependent on the symbiotic relationships between the host and the diverse gut microbiota, which is influenced by the highly co-evolved immune-microbiota interactions.... | 10.1093/procel/pwad028 | 37,191,444 | D006801:Humans; D015212:Inflammatory Bowel Diseases; D000069196:Gastrointestinal Microbiome; D064307:Microbiota; D007107:Immune System; D007422:Intestines | Protein & cell | 2,023 | |
Targeting vaccinations for the licensed dengue vaccine: Considerations for serosurvey design. | BACKGROUND
The CYD-TDV vaccine was unusual in that the recommended target population for vaccination was originally defined not only by age, but also by transmission setting as defined by seroprevalence. WHO originally recommended countries consider vaccination against dengue with CYD-TDV vaccine in geographic settings... | 10.1371/journal.pone.0199450 | 29,944,696 | D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D003715:Dengue; D053059:Dengue Vaccines; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008004:Licensure; D008954:Models, Biological; D011336:Probability; D012680:Sensitivity and Specificity; D016036:Sero... | PloS one | 2,018 | D053059:Dengue Vaccines |
The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID. | We have asked how the human cytomegalovirus major immediate-early 1 (IE1) and 2 (IE2) proteins act to transactivate heterologous cellular and viral promoters. Here we show that transactivation of the human immunodeficiency virus long terminal repeat and the 70,000-molecular-weight heat shock protein (hsp70) promoter by... | 10.1128/JVI.66.7.4452-4456.1992 | 1,318,414 | D002478:Cells, Cultured; D003587:Cytomegalovirus; D016325:HIV Long Terminal Repeat; D015497:HIV-1; D006360:Heat-Shock Proteins; D017874:Immediate-Early Proteins; D008562:Membrane Glycoproteins; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D016385:TATA Box; D015534:Trans-Activators; D03... | Journal of virology | 1,992 | D006360:Heat-Shock Proteins; C088645:IE1 protein, cytomegalovirus; C069186:IE2 protein, Cytomegalovirus; D017874:Immediate-Early Proteins; D008562:Membrane Glycoproteins; D015534:Trans-Activators; D035362:Transcription Factor TFIID; D014157:Transcription Factors; C077406:UL115 protein, Human herpesvirus 5; D014759:Vira... |
Feasibility of fresh frozen human cadavers as a research and training model for endovascular image guided interventions. | OBJECTIVE
To describe the feasibility of a fresh frozen human cadaver model for research and training of endovascular image guided procedures in the aorta and lower extremity.
METHODS
The cadaver model was constructed in fresh frozen human cadaver torsos and lower extremities. Endovascular access was acquired by inse... | 10.1371/journal.pone.0242596 | 33,254,200 | D000368:Aged; D000369:Aged, 80 and over; D001808:Blood Vessels; D002102:Cadaver; D000072226:Computed Tomography Angiography; D015925:Cryopreservation; D057510:Endovascular Procedures; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D025321:Surgery, Computer-Assisted | PloS one | 2,020 | |
Guidelines for Transrectal Ultrasonography-Guided Prostate Biopsy: Korean Society of Urogenital Radiology Consensus Statement for Patient Preparation, Standard Technique, and Biopsy-Related Pain Management. | The Korean Society of Urogenital Radiology (KSUR) aimed to present a consensus statement for patient preparation, standard technique, and pain management in relation to transrectal ultrasound-guided prostate biopsy (TRUS-Bx) to reduce the variability in TRUS-Bx methodologies and suggest a nationwide guideline. The KSUR... | 10.3348/kjr.2019.0576 | 32,193,890 | D000701:Analgesics, Opioid; D000890:Anti-Infective Agents; D000925:Anticoagulants; D004733:Enema; D006801:Humans; D061705:Image-Guided Biopsy; D008012:Lidocaine; D008297:Male; D059408:Pain Management; D011467:Prostate | Korean journal of radiology | 2,020 | D000701:Analgesics, Opioid; D000890:Anti-Infective Agents; D000925:Anticoagulants; D008012:Lidocaine |
Integrated biological treatment of recalcitrant effluents from pulp mills. | This work aimed at determining the degree of depuration of a recalcitrant effluent (weak black liquor, WBL) achieved in a series treatment consisting of a first stage methanogenic fluidised bed reactor followed by a second stage aerobic, upflow reactor packed with "biocubes" of Trametes versicolor immobilised onto smal... | 15,461,409 | D001421:Bacteria, Anaerobic; D019149:Bioreactors; D007220:Industrial Waste; D009930:Organic Chemicals; D010209:Paper; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical | Water science and technology : a journal of the International Association on Water Pollution Research | 2,004 | D007220:Industrial Waste; D009930:Organic Chemicals; D014874:Water Pollutants, Chemical | |
A high-performance liquid chromatography-electrospray-tandem mass spectrometry analysis of cortisol and metabolites in placental perfusate. | A reversed-phase high-performance liquid chromatography-electrospray-tandem mass spectrometry assay (HPLC-ESI-MS/MS) was developed to quantitate cortisol, cortisone, 20 alpha- and beta-dihydrocortisol, 20 alpha- and beta-dihydrocortisone, tetrahydrocortisol, and tetrahydrocortisone. The technique was used to analyze pe... | 10.1006/abio.1997.2074 | 9,177,697 | D042842:11-beta-Hydroxysteroid Dehydrogenases; D002851:Chromatography, High Pressure Liquid; D003348:Cortisone; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006854:Hydrocortisone; D006913:Hydroxysteroid Dehydrogenases; D066298:In Vitro Techniques; D013058:Mass Spectrometry; D010477:Perfusion; D... | Analytical biochemistry | 1,997 | C016499:20-hydroxycortisol; C005674:4-pregnene-17 alpha,20 beta,21-triol-3,11-dione; D013761:Tetrahydrocortisone; D013760:Tetrahydrocortisol; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D003348:Cortisone; D006854:Hydrocortisone |
Preferences for facial and vocal masculinity in homosexual men: the role of relationship status, sexual restrictiveness, and self-perceived masculinity. | Studies on mate preferences usually examine heterosexual attraction; comparatively little is known about preferences of individuals whose sexuality is aimed at the same sex. We examined preferences of two groups of androphilic individuals--homosexual men and heterosexual women--for male facial and vocal level of mascul... | 10.1068/p6909 | 23,700,957 | D000293:Adolescent; D000328:Adult; D005260:Female; D020010:Heterosexuality; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D057228:Masculinity; D008875:Middle Aged; D011581:Psychological Tests; D012649:Self Concept; D012727:Sex Characteristics; D012747:Sexual Partners; D055815:Young Adult | Perception | 2,013 | |
Notable and Emerging Variants of SARS-CoV-2 Virus: A Quick Glance. | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), is a highly contagious pathogenic coronavirus to emerge and spread in human populations. Although substantial exertions have been laid to avert spread of COVID-19 by therapeutic and preventive cou... | 10.1007/s12291-021-00991-0 | 34,219,999 | Indian journal of clinical biochemistry : IJCB | 2,021 | ||
Pleural empyema associated with alveolar-pleural fistulas in severe acute respiratory syndrome coronavirus 2. | Surgery in COVID-19 disease complicated by APF represents the last life-saving treatment option. The choice of the therapeutic period to indicate this approach is fundamental. In fact, the clinical stability of patient is necessary in order to allow single-lung ventilation and to minimize postoperative sequelae. | 10.1002/ccr3.4262 | 34,188,928 | Clinical case reports | 2,021 | ||
Compartmental analysis of metals in waterpipe smoking technique. | BACKGROUND
The number of waterpipe tobacco smokers has been increasing worldwide. Smokers can be exposed to a number of toxicants, some of which are metals. The aim of this study is to quantitatively determine if the water filtration stage of the waterpipe smoking process successfully decreases exposure to Bi, Cr, Cu, ... | 10.1186/s12889-015-1373-6 | 25,884,883 | D006801:Humans; D019570:Inhalation Exposure; D008670:Metals; D012907:Smoking; D014026:Nicotiana; D014867:Water | BMC public health | 2,015 | D008670:Metals; D014867:Water |
[Side effects of immune checkpoint inhibitor therapy : What intensive care specialists need to know]. | Immunotherapies, and in particular checkpoint inhibitors, have revolutionized the treatment of cancer. However, due to their mechanism of action, the activation of the body's own T cells, side effects are frequently associated with these therapies. So-called immune-related adverse events (irAEs) manifest as autoimmunol... | 10.1007/s00063-023-01057-0 | 37,661,230 | Medizinische Klinik, Intensivmedizin und Notfallmedizin | 2,023 | ||
Mid- and long-term outcome of patients with permanent inferior vena cava filters: a single center review. | BACKGROUND
Inferior vena cava (IVC) filters are used to prevent pulmonary embolism (PE), especially in patients with active contraindication to systemic anticoagulation. The aim of this study is to examine the outcomes of patients who received permanent IVC filters at our institution.
METHODS
This is a single-center ... | 25,757,994 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants; D016009:Chi-Square Distribution; D016208:Databases, Factual; D005260:Female; D006723:Hong Kong; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D054070:Postthrombotic Syndrome; D016016... | Annals of vascular surgery | 2,015 | D000925:Anticoagulants | |
The effect of the Covid-19 shutdown on glycemic testing and control. | BACKGROUND
The coronavirus disease 2019 (COVID-19) pandemic caused a halt to in-person ambulatory care. We evaluated how the reduction in access to care affected HbA1c testing and patient HbA1c levels.
METHODS
HbA1c data from 11 institutions were extracted to compare testing volume and the percentage of abnormal resu... | 10.1016/j.cca.2021.04.018 | 33,932,408 | D000086382:COVID-19; D006801:Humans; D010045:Outpatients; D058873:Pandemics; D012189:Retrospective Studies; D000086402:SARS-CoV-2 | Clinica chimica acta; international journal of clinical chemistry | 2,021 | |
Association between single-nucleotide polymorphisms of DNMT3L and infertility with azoospermia in Chinese men. | The gene for DNA methyltransferase 3-like protein (DNMT3L) is essential for normal spermatogenesis and may be involved with spermatogenetic impairment and male infertility. To explore the possible association between the DNMT3L gene and male infertility, this study investigated allele, genotype and haplotype frequencie... | 10.1016/j.rbmo.2011.09.004 | 22,116,073 | D000328:Adult; D000483:Alleles; D053713:Azoospermia; D002681:China; D004248:DNA (Cytosine-5-)-Methyltransferases; D019175:DNA Methylation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007248:Infertility, Male; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; ... | Reproductive biomedicine online | 2,012 | C412484:DNMT3L protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases |
The redox biology network in cancer pathophysiology and therapeutics. | The review pinpoints operational concepts related to the redox biology network applied to the pathophysiology and therapeutics of solid tumors. A sophisticated network of intrinsic and extrinsic cues, integrated in the tumor niche, drives tumorigenesis and tumor progression. Critical mutations and distorted redox signa... | 10.1016/j.redox.2015.06.014 | 26,122,399 | D000975:Antioxidants; D051858:Forkhead Transcription Factors; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D000072019:Kelch-Like ECH-Associated Protein 1; D020928:Mitogen-Activated Protein Kinases; D051267:NF-E2-Related Factor 2; D009369:Neoplasms; D018384:Oxidative Stress; D017319:Photosensit... | Redox biology | 2,015 | D000975:Antioxidants; D051858:Forkhead Transcription Factors; D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D020928:Mitogen-Activated P... |
An overview of upcoming changes in pregnancy and lactation labeling information. | BACKGROUND
Many medications can be used safely and effectively to provide health benefits for disease state management during pregnancy with minimal risk to the fetus or mother. Today nine out of ten women take at least one medication during pregnancy, and the number of women taking four or more medications has more th... | 10.18549/pharmpract.2015.02.605 | 26,131,048 | Pharmacy practice | 2,015 | ||
Utilization management, case management, and you. | Historically, most monitoring functions have been carried out by insurance companies. Monitoring costs was considered their fiduciary obligation to their customers. The exercise of this fiduciary obligation kept premiums low, while increasing or maintaining the benefit levels. Risk (the assumption of losses generated b... | 10,141,924 | D003363:Cost Control; D007342:Insurance Benefits; D016365:Liability, Legal; D008329:Managed Care Programs; D012308:Risk Management; D014481:United States; D014600:Utilization Review | Physician executive | 1,995 | ||
The Effect of Two Types of Pasta Versus White Rice on Postprandial Blood Glucose Levels in Adults with Type 1 Diabetes: A Randomized Crossover Trial. | Food choices are essential to successful glycemic control for people with diabetes. We compared the impact of three carbohydrate-rich meals on the postprandial glycemic response in adults with type 1 diabetes (T1D). We performed a randomized crossover study in 12 adults with T1D (age 58.7 ± 14.2 years, baseline hemogl... | 10.1089/dia.2019.0109 | 31,225,739 | D000328:Adult; D001786:Blood Glucose; D015190:Blood Glucose Self-Monitoring; D018592:Cross-Over Studies; D003922:Diabetes Mellitus, Type 1; D004040:Dietary Carbohydrates; D002523:Edible Grain; D005260:Female; D038321:Glycemic Index; D006801:Humans; D007004:Hypoglycemic Agents; D007328:Insulin; D008297:Male; D062407:Mea... | Diabetes technology & therapeutics | 2,019 | D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007004:Hypoglycemic Agents; D007328:Insulin |
Pathogenicity and molecular characterization of infectious bursal disease virus in China. | Infectious bursal disease virus (IBDV) caused an acute and highly contagious infectious disease, resulting in considerable economic losses in the world poultry industry. Although this disease was well-controlled under the widely use of commercial vaccines, the novel variant IBDV strain emerged due to the highly immuniz... | 10.1016/j.psj.2021.101502 | 34,871,986 | D000818:Animals; D002645:Chickens; D002681:China; D007243:Infectious bursal disease virus; D014774:Virulence | Poultry science | 2,022 | |
Achieving mainstream nitrogen and phosphorus removal through Simultaneous partial Nitrification, Anammox, Denitrification, and Denitrifying Phosphorus Removal (SNADPR) process in a single-tank integrative reactor. | Simultaneous partial Nitrification, Anammox, and Denitrification (SNAD) is a promising and energy-efficient nitrogen removal process, which is powerless to eliminate phosphorus and confronted the problem of excessive effluent nitrate once applied in municipal sewage treatment characterized with high C/N ratio (≥2). Her... | 10.1016/j.biortech.2019.03.109 | 30,925,426 | D064751:Ammonium Compounds; D018441:Biofilms; D019149:Bioreactors; D058440:Denitrification; D009566:Nitrates; D058465:Nitrification; D009584:Nitrogen; D010758:Phosphorus; D061328:Planctomycetales; D012722:Sewage | Bioresource technology | 2,019 | D064751:Ammonium Compounds; D009566:Nitrates; D012722:Sewage; D010758:Phosphorus; D009584:Nitrogen |
Increased activated memory B-cells in the peripheral blood of patients with erythema nodosum leprosum reactions. | B-cells, in addition to antibody secretion, have emerged increasingly as effector and immunoregulatory cells in several chronic inflammatory diseases. Although Erythema Nodosum Leprosum (ENL) is an inflammatory complication of leprosy, the role of B- cell subsets has never been studied in this patient group. Therefore,... | 10.1371/journal.pntd.0006121 | 29,253,897 | D000893:Anti-Inflammatory Agents; D000907:Antibodies, Bacterial; D001402:B-Lymphocytes; D016022:Case-Control Studies; D004893:Erythema Nodosum; D005002:Ethiopia; D006801:Humans; D007156:Immunologic Memory; D007918:Leprosy; D018655:Lymphocyte Count; D009166:Mycobacterium leprae; D011239:Prednisolone; D013601:T-Lymphocyt... | PLoS neglected tropical diseases | 2,017 | D000893:Anti-Inflammatory Agents; D000907:Antibodies, Bacterial; D011239:Prednisolone |
Women's physical activity and pregnancy outcome: a longitudinal analysis from the Philippines. | We assessed the effects of physical activity on pregnancy outcome in 2741 Filipino women identified during pregnancy as part of a two-year longitudinal study. Specific elements of physical activity hypothesized to be relevant to pregnancy outcome were posture, energy expenditure, and physical stress. Variables were dev... | 10.1093/ije/20.1.162 | 2,066,216 | D000328:Adult; D015331:Cohort Studies; D003906:Developing Countries; D015444:Exercise; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008137:Longitudinal Studies; D010679:Philippines; D011247:Pregnancy; D011256:Pregnancy Outcome; D014931:Women, Working | International journal of epidemiology | 1,991 | |
Abundance, diversity, and activity of ammonia-oxidizing prokaryotes in the coastal Arctic ocean in summer and winter. | Ammonia oxidation, the first step in nitrification, is performed by certain Beta- and Gammaproteobacteria and Crenarchaea to generate metabolic energy. Ammonia monooxygenase (amoA) genes from both Bacteria and Crenarchaea have been found in a variety of marine ecosystems, but the relative importance of Bacteria versus ... | 10.1128/AEM.01907-10 | 21,239,542 | D000641:Ammonia; D001105:Archaea; D001110:Arctic Regions; D020562:Betaproteobacteria; D020563:Gammaproteobacteria; D009792:Oceans and Seas; D010088:Oxidoreductases; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S; D012621:Seasons; D012623:Seawater | Applied and environmental microbiology | 2,011 | D012336:RNA, Ribosomal, 16S; D000641:Ammonia; D010088:Oxidoreductases; C045582:ammonia monooxygenase |
Measurement invariance of language brokering extent and attitudes in linguistic minority adolescents: Item response theory analyses. | OBJECTIVE
Using item response theory, we sought to evaluate measurement invariance of language brokering extent and attitudes in 3 linguistic minority groups of adolescents.
METHOD
The sample included 765 (302 Chinese American, 327 Korean American, and 136 Mexican American; 57% females) ninth graders from immigrant f... | 10.1037/cdp0000224 | 30,307,261 | D000293:Adolescent; D000294:Adolescent Behavior; D001213:Asian; D054242:Emigrants and Immigrants; D005260:Female; D006801:Humans; D007802:Language; D008037:Linguistics; D008297:Male; D017058:Mexican Americans; D008913:Minority Groups; D011594:Psychometrics; D015203:Reproducibility of Results; D011795:Surveys and Questi... | Cultural diversity & ethnic minority psychology | 2,019 | |
Predictive value of HBsAg quantification for determining the clinical course of genotype C HBeAg-negative carriers. | BACKGROUND/AIMS
Hepatitis B virus surface antigen (HBsAg) quantification has been suggested to discriminate inactive carriers from hepatitis e antigen (HBeAg) negative chronic hepatitis, but it could be genotype-dependent. We studied the predictive value of HBsAg quantification in genotype C HBeAg-negative hepatitis B ... | 10.1111/j.1478-3231.2011.02693.x | 22,128,792 | D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers; D002353:Carrier State; D004279:DNA, Viral; D005260:Female; D005838:Genotype; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic; D006801:Humans; D008297:Male; D008875:Mid... | Liver international : official journal of the International Association for the Study of the Liver | 2,012 | D015415:Biomarkers; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens |
Mentor Mothers Program Improved Child Health Outcomes At A Relatively Low Cost In South Africa. | In light of South Africa's high prenatal HIV prevalence and infant mortality rate, a cluster randomized controlled trial was conducted to evaluate an intervention called Philani+, which used community health workers (known as Mentor Mothers) to deliver pre- and postnatal home visits in Cape Town, South Africa, to impro... | 10.1377/hlthaff.2017.0553 | 29,137,500 | D000293:Adolescent; D000328:Adult; D002648:Child; D000067576:Child Health; D003150:Community Health Workers; D003362:Cost-Benefit Analysis; D005260:Female; D006792:House Calls; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008611:Mentors; D009035:Mothers; D011181:Postnatal Care; D011247:Pregnancy; D011295:P... | Health affairs (Project Hope) | 2,017 | |
Simulation of the Strain Amplification in Sulci Due to Blunt Impact to the Head. | Traumatic brain injury (TBI) has become a concern in sports, automobile accidents and combat operations. A better understanding of the mechanics leading to a TBI is required to cope with both the short-term life-threatening effects and long-term effects of TBIs, such as the development chronic traumatic encephalopathy ... | 10.3389/fneur.2020.00998 | 33,013,659 | Frontiers in neurology | 2,020 | ||
Hormonal regulation of the osteoblastic phenotype expression in neonatal murine calvarial cells. | Osteoblastic cell cultures from fetal rat calvariae have provided a popular model for studying the effects of dexamethasone (DEX) and 1, 25 dihydroxyvitamin D3 [1,25(OH)2D3] on gene expression but data from murine calvarial cells are scarce. Species-specific responses of rat and mouse osteoblastic cells to these hormon... | 10.1007/s002239900624 | 10,089,223 | D000469:Alkaline Phosphatase; D000818:Animals; D000831:Animals, Newborn; D015415:Biomarkers; D002478:Cells, Cultured; D003907:Dexamethasone; D005938:Glucocorticoids; D051379:Mice; D010006:Osteoblasts; D015675:Osteocalcin; D010012:Osteogenesis; D010641:Phenotype; D012886:Skull; D013045:Species Specificity; D013997:Time ... | Calcified tissue international | 1,999 | D015415:Biomarkers; D005938:Glucocorticoids; D015675:Osteocalcin; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D003907:Dexamethasone; D000469:Alkaline Phosphatase |
Fibrinogen synthesis in serum-free hepatocyte cultures: stimulation by glucocorticoids. | Fibrinogen synthesis was investigated in cultures of chicken embryo hepatocytes initiated and maintained in chemically defined, serum-free medium. 11-Hydroxy glucocorticoids caused a 3-fold stimulation of fibrinogen synthesis. Half-maximal stimulation was achieved with 1 nM corticosterone or hydrocortisone, as compared... | 10.1073/pnas.75.11.5506 | 281,699 | D000818:Animals; D001798:Blood Proteins; D002478:Cells, Cultured; D002642:Chick Embryo; D003907:Dexamethasone; D005340:Fibrinogen; D005938:Glucocorticoids; D006493:Heparin; D006854:Hydrocortisone; D007123:Immunoelectrophoresis, Two-Dimensional; D008099:Liver | Proceedings of the National Academy of Sciences of the United States of America | 1,978 | D001798:Blood Proteins; D005938:Glucocorticoids; D003907:Dexamethasone; D005340:Fibrinogen; D006493:Heparin; D006854:Hydrocortisone |
Fast magnetic resonance coronary angiography with a three-dimensional stack of spirals trajectory. | In this work, three-dimensional (3D) spiral imaging has been utilized for magnetic resonance coronary angiography. Spiral-based 3D techniques can dramatically reduce imaging time requirements compared with 3D Fourier Transform imaging. The method developed here utilized a "stack of spirals" trajectory, to traverse 3D k... | 10.1002/(sici)1522-2594(199906)41:6<1170::aid-mrm13>3.0.co;2-j | 10,371,449 | D000465:Algorithms; D003331:Coronary Vessels; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography | Magnetic resonance in medicine | 1,999 | |
Aedes aegypti (L.) and Aedes albopictus (Skuse) in Singapore City. 2. Larval habitats. | Detailed information on the breeding habitats of Ae. aegypti and Ae. albopictus is necessary when planning programmes for their control. The larval habitats of the two species in 10 city areas were counted and classified according to type, frequency of occurrence, location, and function. Of all the breeding habitats re... | 5,316,746 | D000330:Aedes; D001947:Breeding; D004197:Disease Reservoirs; D006798:Housing; D006801:Humans; D007303:Insect Vectors; D007814:Larva; D012846:Singapore | Bulletin of the World Health Organization | 1,971 | ||
A quantum transfer matrix method for one-dimensional disordered electronic systems. | We develop a novel quantum transfer matrix method to study thermodynamic properties of one-dimensional (1D) disordered electronic systems. It is shown that the partition function can be expressed as a product of 2 × 2 local transfer matrices. We demonstrate this method by applying it to the 1D disordered Anderson model... | 10.1088/0953-8984/21/14/145407 | 21,825,338 | Journal of physics. Condensed matter : an Institute of Physics journal | 2,009 | ||
Antimicrobial susceptibility and genetic characteristics of Streptococcus pneumoniae isolates indicating possible nosocomial transmission routes in a community hospital in Japan. | A clinical study was designed to study Streptococcus pneumoniae isolates recovered from a community hospital in Japan from April 2001 to November 2002. A total of 73 isolates were defined as derived from inpatient, outpatient, and hospital staff groups. The MIC results showed that 20 strains (27.4%) were susceptible to... | 10.1128/JCM.01138-07 | 17,855,576 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003428:Cross Infection; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006764:Hospitals, Community; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle A... | Journal of clinical microbiology | 2,007 | |
Immunosuppressive prednisolone enhances early cholangiocarcinoma in Syrian hamsters with liver fluke infection and administration of N-nitrosodimethylamine. | Chronic infection with Opisthorchis viverrini for many years has been associated with the development of hepatobiliary diseases including cholangiocarcinoma. It is well known that inflammation is a key component of the tumor microenvironment, and that chronic inflammation plays an important role in tumorigenesis. There... | 10.1007/s12253-012-9557-1 | 22,851,165 | D000818:Animals; D001650:Bile Duct Neoplasms; D002471:Cell Transformation, Neoplastic; D018281:Cholangiocarcinoma; D002908:Chronic Disease; D003043:Cocarcinogenesis; D006224:Cricetinae; D051546:Cyclooxygenase 2; D004128:Dimethylnitrosamine; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents; D007249:Inflamm... | Pathology oncology research : POR | 2,013 | D007166:Immunosuppressive Agents; D011239:Prednisolone; D051546:Cyclooxygenase 2; D004128:Dimethylnitrosamine |
Administration of 8-OH-DPAT into the midbrain raphe nuclei: effects on medial hypothalamic NE-induced feeding. | The 5-hydroxytryptamine (5-HT)1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) has been shown to elicit dose-dependent feeding in satiated rats when injected into the midbrain raphe nuclei. Because the feeding-stimulatory effects of this compound are associated with reduced 5-HT release in forebrain, and b... | 10.1152/ajpregu.1994.266.5.R1645 | 8,203,645 | D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior; D007033:Hypothalamus, Middle; D008297:Male; D008845:Microinjections; D009638:Norepinephrine; D010286:Paraventricular Hypothalamic Nucleus; D011903:Raphe Nuclei; D051381:Rats; D017207:Rats... | The American journal of physiology | 1,994 | D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D009638:Norepinephrine |
Identification of Key Long Non-Coding RNAs in the Pathology of Alzheimer's Disease and their Functions Based on Genome-Wide Associations Study, Microarray, and RNA-seq Data. | The pathogenesis of Alzheimer's disease (AD) is identified to be significantly regulated by long non-coding RNA (lncRNA) based on in vivo and clinical experiments. Single nucleotide polymorphisms (SNPs) can strongly impact expression and function of lncRNA in AD, and previous genome-wide associations studies (GWAS) hav... | 10.3233/JAD-181051 | 30,776,002 | D000544:Alzheimer Disease; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding; D000081246:RNA-Seq | Journal of Alzheimer's disease : JAD | 2,019 | D062085:RNA, Long Noncoding |
A Survey and Analysis of the American Public's Perceptions and Knowledge About Antibiotic Resistance. | Background. Little is known about the American public's perceptions or knowledge about antibiotic-resistant bacteria or antibiotic misuse. We hypothesized that although many people recognize antibiotic resistance as a problem, they may not understand the relationship between antibiotic consumption and selection of res... | 10.1093/ofid/ofw112 | 27,382,598 | Open forum infectious diseases | 2,016 | ||
A Citrus Phosphate Starvation Response Factor CsPHL3 Negatively Regulates Carotenoid Metabolism. | Carotenoids provide precursors for the biosynthesis of strigolactones, which are a new class of hormones that are essential in phosphate (Pi) signaling during plant development. Carotenoid metabolism is a finely tuned pathway, but our understanding of the regulation mechanisms is still limited. In this study, we isolat... | 10.1093/pcp/pcab007 | 33,493,291 | D002338:Carotenoids; D032084:Citrus sinensis; D018506:Gene Expression Regulation, Plant; D018551:Solanum lycopersicum; D010710:Phosphates; D045331:Photosystem I Protein Complex; D010940:Plant Proteins; D030821:Plants, Genetically Modified; D017422:Sequence Analysis, DNA; D014157:Transcription Factors; D020798:Two-Hybri... | Plant & cell physiology | 2,021 | D010710:Phosphates; D045331:Photosystem I Protein Complex; D010940:Plant Proteins; D014157:Transcription Factors; D002338:Carotenoids |
Traffic pollution at the home address and pregnancy outcomes in Stockholm, Sweden. | BACKGROUND
For the past two decades, several studies have reported associations between elevated levels of ambient air pollution and adverse pregnancy outcomes, although with varying conclusions.
OBJECTIVES
To examine possible associations between the traffic pollution situation at the home address, for women who did... | 10.1136/bmjopen-2014-007034 | 26,275,899 | D000328:Adult; D000393:Air Pollutants; D000397:Air Pollution; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016015:Logistic Models; D008297:Male; D018811:Maternal Exposure; D018986:Motor Vehicles; D009589:Nitrogen Oxide... | BMJ open | 2,015 | D000393:Air Pollutants; D009589:Nitrogen Oxides; D001335:Vehicle Emissions |
Twisting is key: Removing an infected nitinol wire braided uncovered stent from the aortic arch and the descending aorta. | Prosthesis infection after aortic surgery is a critical complication that most commonly requires surgical treatment with removal of the infected material. In this video tutorial, we remove a novel nitinol wire braided stent. It was introduced to stabilize the true lumen and prevent distal anastomotic new entry. Both th... | 10.1510/mmcts.2022.019 | 36,218,303 | D000497:Alloys; D000784:Aortic Dissection; D001013:Aorta, Thoracic; D017545:Aortic Aneurysm, Thoracic; D019917:Blood Vessel Prosthesis Implantation; D006801:Humans; D011183:Postoperative Complications; D015607:Stents; D016896:Treatment Outcome | Multimedia manual of cardiothoracic surgery : MMCTS | 2,022 | D000497:Alloys; C013616:nitinol |
How much do we throw away in the intensive care unit? An observational point prevalence study of Australian and New Zealand ICUs. | Objective
During the current COVID pandemic, waste generation has been more evident with increased use of single use masks, gowns and other personal protective equipment. We aimed to understand the scale of waste generation, recycling rates and participation in Australian and New Zealand (ANZ) ICUs.
Design
This is a ... | 10.1016/j.ccrj.2023.05.004 | 37,876,601 | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine | 2,023 | ||
Microbial detoxification of mycotoxins in food and feed. | Mycotoxins are metabolites produced by fungi growing in food or feed, which can produce toxic effects and seriously threaten the health of humans and animals. Mycotoxins are commonly found in food and feed, and are of significant concern due to their hepatotoxicity, nephrotoxicity, carcinogenicity, mutagenicity, and ab... | 10.1080/10408398.2021.1879730 | 33,663,294 | D000821:Animal Feed; D000818:Animals; D005506:Food Contamination; D037341:Fumonisins; D009183:Mycotoxins; D015025:Zearalenone | Critical reviews in food science and nutrition | 2,022 | D037341:Fumonisins; D009183:Mycotoxins; D015025:Zearalenone |
Genomic organization of a mouse type I activin receptor. | We have characterized the genomic organization of a mouse type I activin receptor. Using the mouse tsk7L cDNA, 4 overlapping lambda clones containing the activin receptor IA (ActRIA) gene were isolated from a mouse 129 Sv genomic library. The mouse ActRIA gene is encoded by 10 exons and spans approximately 40 kb. The s... | 10.1006/bbrc.1995.2118 | 7,639,738 | D029404:Activin Receptors; D000818:Animals; D001483:Base Sequence; D001921:Brain; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA; D017931:DNA Primers; D005091:Exons; D015698:Genomic Library; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D009928:... | Biochemical and biophysical research communications | 1,995 | D017931:DNA Primers; D017978:Receptors, Growth Factor; D004247:DNA; D017346:Protein Serine-Threonine Kinases; D029404:Activin Receptors |
The role of reparative processes in teratogenesis. | Introducing the review article the multiple relations between reparative processes and prenatal development are briefly discussed. In continuation the theoretical framework of possible and plausible repair in teratogenesis is outlined and documented by some, so far existing direct and indirect examples from experimenta... | 9,747,109 | D000014:Abnormalities, Drug-Induced; D000818:Animals; D005260:Female; D006801:Humans; D011247:Pregnancy; D013723:Teratogens | Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie | 1,997 | D013723:Teratogens | |
Attitudinal and contextual factors associated with discussion of sexual issues during adolescent health visits. | PURPOSE
To examine attitudinal and contextual factors associated with the occurrence of sexual health assessments during adolescent primary care visits.
METHODS
A total of 313 primarily African-American youth aged 11-21 years from 16 community-based organizations in suburban Maryland and in New York City completed qu... | 10.1016/j.jadohealth.2003.09.011 | 15,261,639 | D000293:Adolescent; D000294:Adolescent Behavior; D016497:Adolescent Health Services; D000328:Adult; D001294:Attitude to Health; D044383:Black People; D016009:Chi-Square Distribution; D002648:Child; D003268:Contraception Behavior; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008396:Maryland; D... | The Journal of adolescent health : official publication of the Society for Adolescent Medicine | 2,004 | |
Long-term motor cortex plasticity induced by an electronic neural implant. | It has been proposed that the efficacy of neuronal connections is strengthened when there is a persistent causal relationship between presynaptic and postsynaptic activity. Such activity-dependent plasticity may underlie the reorganization of cortical representations during learning, although direct in vivo evidence is... | 10.1038/nature05226 | 17,057,705 | D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D008254:Macaca nemestrina; D008297:Male; D009044:Motor Cortex; D009068:Movement; D009473:Neuronal Plasticity; D013997:Time Factors; D019415:Torque | Nature | 2,006 | |
Correlation of C-reactive Protein with Delirium in Obstetrics Intensive Care Unit: A Tertiary Center Experience. | Background
Delirium is a neuropsychiatric illness. It affects critically ill patients on ventilator and increases mortality. The aim of this study was to evaluate the association of C-reactive protein (CRP) level with delirium in critically obstetrics women and its role in prediction of delirium.
Materials and method... | 10.5005/jp-journals-10071-24455 | 37,214,122 | Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine | 2,023 | ||
Pathophysiology and clinical aspects of fibrinolysis and inhibition of coagulation. Experimental and clinical studies with special reference to women on oral contraceptives and selected groups of thrombosis prone patients. | The primary aim of the haemostatic mechanism is to protect the vascular system and to keep it intact after injury in order to secure the function of tissues and organs. A second aim is to provide a matrix in wound healing and tissue repair. The regulation of this physiological mechanism is effected by a dynamic haemost... | 3,277,796 | D020152:Antithrombin III Deficiency; D001777:Blood Coagulation; D003276:Contraceptives, Oral; D004198:Disease Susceptibility; D005260:Female; D005342:Fibrinolysis; D012739:Gonadal Steroid Hormones; D006487:Hemostasis; D006801:Humans; D010960:Plasminogen Activators; D013923:Thromboembolism | Danish medical bulletin | 1,988 | D003276:Contraceptives, Oral; D012739:Gonadal Steroid Hormones; D010960:Plasminogen Activators | |
[A case of diabetic glomerulosclerosis without concurrent diabetes mellitus]. | Diabetic nephropathy is a complication of diabetes mellitus that is characterized by the appearance of diffuse and nodular glomerulosclerosis A 46-year-old man presented with generalized edema. He had severe nephrotic syndrome, renal insufficiency and hypertension without a family history or clinical evidence of diabet... | 12,476,593 | D003920:Diabetes Mellitus; D003928:Diabetic Nephropathies; D003930:Diabetic Retinopathy; D003937:Diagnosis, Differential; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome | Nihon Jinzo Gakkai shi | 2,002 | ||
A novel prognostic model based on multi-omics features predicts the prognosis of colon cancer patients. | BACKGROUND
As a common malignant tumor in the colon, colon cancer (CC) has high incidence and recurrence rates. This study is designed to build a prognostic model for CC.
METHODS
The gene expression dataset, microRNA-seq dataset, copy number variation (CNV) dataset, DNA methylation dataset, and transcription factor (... | 10.1002/mgg3.1255 | 32,396,280 | D014408:Biomarkers, Tumor; D003110:Colonic Neoplasms; D019175:DNA Methylation; D000081122:Epigenome; D023281:Genomics; D006801:Humans; D049451:Nomograms; D059467:Transcriptome | Molecular genetics & genomic medicine | 2,020 | D014408:Biomarkers, Tumor |
Association of Common Polymorphisms in the Interleukin-1 Beta Gene with Hepatocellular Carcinoma in Caucasian Patients with Chronic Hepatitis B. | Interleukin-1 beta (IL-1β) promotes liver disease progression and hepatocarcinogenesis in chronic hepatitis B (CHB). Single nucleotide polymorphisms (SNPs) within the promotor region of the IL-1β gene can affect the progression towards liver cirrhosis and hepatocellular carcinoma (HCC). Aims: We aimed to investigate th... | 10.3390/pathogens12010054 | 36,678,401 | Pathogens (Basel, Switzerland) | 2,022 | ||
[Thyroid function in patients with Yusho]. | To evaluate chronic effect of polychlorinated biphenyl (PCB) on thyroid functions, thyroid hormone levels were studied in 115 patients with Yusho in 2002. Serum level of thyroid stimulating hormone (TSH) was elevated in 13 cases (11.3%). All of them showed normal triiodothyronine (T3) and thyroxine (T4) levels, and reg... | 12,872,709 | D000328:Adult; D000368:Aged; D015415:Biomarkers; D005260:Female; D005506:Food Contamination; D006801:Humans; D007037:Hypothyroidism; D008297:Male; D008875:Middle Aged; D012275:Oryza; D010938:Plant Oils; D011078:Polychlorinated Biphenyls; D013960:Thyroid Function Tests; D013961:Thyroid Gland; D013972:Thyrotropin; D01397... | Fukuoka igaku zasshi = Hukuoka acta medica | 2,003 | D015415:Biomarkers; D010938:Plant Oils; D014284:Triiodothyronine; D013972:Thyrotropin; D011078:Polychlorinated Biphenyls; D013974:Thyroxine | |
Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme. | Cystalysin is a C(beta)-S(gamma) lyase from the oral pathogen Treponema denticola catabolyzing L-cysteine to produce pyruvate, ammonia and H(2)S. With its ability to induce cell lysis, cystalysin represents a new class of pyridoxal 5'-phosphate (PLP)-dependent virulence factors. The crystal structure of cystalysin was ... | 10.1093/emboj/19.13.3168 | 10,880,431 | D001665:Binding Sites; D002384:Catalysis; D018360:Crystallography, X-Ray; D003542:Cystathionine gamma-Lyase; D005998:Glycine; D006460:Hemolysin Proteins; D006461:Hemolysis; D006862:Hydrogen Sulfide; D008958:Models, Molecular; D017510:Protein Folding; D011732:Pyridoxal Phosphate; D013455:Sulfur; D014208:Treponema | The EMBO journal | 2,000 | D006460:Hemolysin Proteins; D011732:Pyridoxal Phosphate; D013455:Sulfur; C400145:cystalysin; D003542:Cystathionine gamma-Lyase; C088137:aminoethoxyvinylglycine; D005998:Glycine; D006862:Hydrogen Sulfide |
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