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Deletion of Mitochondrial Porin Alleviates Stress Sensitivity in the Yeast Model of Shwachman-Diamond Syndrome. | Shwachman-Diamond syndrome (SDS) is a multi-system disorder characterized by bone marrow failure, pancreatic insufficiency, skeletal abnormalities, and increased risk of leukemic transformation. Most patients with SDS contain mutations in the Shwachman-Bodian-Diamond syndrome gene (SBDS), encoding a highly conserved pr... | 26,743,985 | D001855:Bone Marrow Diseases; D059865:Endoplasmic Reticulum Stress; D010188:Exocrine Pancreatic Insufficiency; D017353:Gene Deletion; D006358:Hot Temperature; D006801:Humans; D008068:Lipomatosis; D008928:Mitochondria; D018272:Porins; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D00008100... | Journal of genetics and genomics = Yi chuan xue bao | 2,015 | C580894:Por1 protein, S cerevisiae; D018272:Porins; D029701:Saccharomyces cerevisiae Proteins; C520002:Sdo1 protein, S cerevisiae | |
Racial Disparities in Cardiovascular Health Behaviors: The Coronary Artery Risk Development in Young Adults Study. | INTRODUCTION
There are known racial differences in cardiovascular health behaviors, including smoking, physical activity, and diet quality. A better understanding of these differences may help identify intervention targets for reducing cardiovascular disease disparities. This study examined whether socioeconomic, psych... | 10.1016/j.amepre.2018.03.017 | 29,776,780 | D003324:Coronary Artery Disease; D005260:Female; D015438:Health Behavior; D054624:Health Status Disparities; D006801:Humans; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012111:Residence Characteristics; D012307:Risk Factors; D012959:Socioeconomic Factors; D055815:Young Adult | American journal of preventive medicine | 2,018 | |
Effects of indomethacin on lymphocyte proliferation, suppressor cell function, and leukocyte migration inhibitory factor (lmif) production. | The in vitro effect of indomethacin (IND) on PHA- and Con-A-induced immune responses was studied. The results showed that the enhancement of both PHA and Con A responses by IND does not significantly depend on the concentrations of mitogens or IND. A significant negative correlation was found between the initial PHA re... | 10.1016/0162-3109(82)90005-4 | 6,213,582 | D002478:Cells, Cultured; D003208:Concanavalin A; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D007213:Indomethacin; D007961:Leukocyte Migration-Inhibitory Factors; D008213:Lymphocyte Activation; D008222:Lymphokines; D010835:Phytohemagglutinins; D013601:T-Lymphocytes; D050... | Immunopharmacology | 1,982 | D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D010835:Phytohemagglutinins; D003208:Concanavalin A; D007213:Indomethacin |
McTear v Imperial Tobacco: understanding the role and limitations of expert epidemiological evidence in scientific litigation. | The use of epidemiological evidence in litigation presents a range of challenges for both litigants and the courts. Given the complex statistical basis of epidemiology itself, it is possible that the technical and factual constraints associated with such evidence may fail to be properly considered by a trier of fact. T... | 16,756,216 | D015984:Causality; D004813:Epidemiology; D005104:Expert Testimony; D006801:Humans; D012606:Scotland; D012907:Smoking; D019460:Tobacco Industry | Journal of law and medicine | 2,006 | ||
Overall Survival Prediction of Glioma Patients With Multiregional Radiomics. | Radiomics-guided prediction of overall survival (OS) in brain gliomas is seen as a significant problem in Neuro-oncology. The ultimate goal is to develop a robust MRI-based approach (i.e., a radiomics model) that can accurately classify a novel subject as a short-term survivor, a medium-term survivor, or a long-term su... | 10.3389/fnins.2022.911065 | 35,873,825 | Frontiers in neuroscience | 2,022 | ||
Clinical mimics of acute appendicitis: Is there any role of imaging? | Acute appendicitis (AA) is a common surgical emergency. Accurate and timely diagnosis of AA is essential for successful outcome. Imaging plays an important role in the diagnosis, exclusion of AA as well as diagnosing alternative clinical conditions which can closely simulate AA. A correct alterative diagnosis may obvia... | 10.1016/j.mjafi.2015.01.017 | 27,546,971 | Medical journal, Armed Forces India | 2,016 | ||
Medicare program; selected performance information on hospitals providing care to Medicare beneficiaries--HCFA. Notice with comment period. | This notice announces our intent to release, through a HCFA publication, selected statistical information on the performance of hospitals participating in the Medicare program. We believe that information about hospitals' overall post-admission mortality rates and specific mortality rates for certain medical conditions... | 10,301,834 | D014487:Centers for Medicare and Medicaid Services, U.S.; D006079:Government Publications as Topic; D006761:Hospitals; D006801:Humans; D006278:Medicare; D009026:Mortality; D014481:United States | Federal register | 1,987 | ||
Features of COPD as Predictors of Lung Cancer. | BACKGROUND
Lung cancer is a leading cause of death and hospitalization for patients with COPD. A detailed understanding of which clinical features of COPD increase risk is needed.
METHODS
We performed a nested case-control study of Genetic Epidemiology of COPD (COPDGene) Study subjects with and without lung cancer, a... | 10.1016/j.chest.2018.01.049 | 29,452,098 | D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018450:Disease Progression; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D015994:Incidence; D008168:Lung; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; ... | Chest | 2,018 | |
A standardised computed tomography measurement method for distal fibular rotation. | PURPOSE
The aim of the study is to identify an ideal location to measure fibular rotation in the ankle joint using axial computed tomography (CT) scans. Another objective was to detect the average fibular rotation in the uninjured ankle joint in a large cohort.
METHODS
Standardised axial CT with coronal/sagittal reco... | 10.1007/s00068-019-01120-6 | 30,963,184 | D016512:Ankle Injuries; D000843:Ankle Joint; D005260:Female; D005360:Fibula; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed | European journal of trauma and emergency surgery : official publication of the European Trauma Society | 2,021 | |
Towards Causality-Aware Inferring: A Sequential Discriminative Approach for Medical Diagnosis. | Medical diagnosis assistant (MDA) aims to build an interactive diagnostic agent to sequentially inquire about symptoms for discriminating diseases. However, since the dialogue records for building a patient simulator are collected passively, the collected records might be deteriorated by some task-unrelated biases, suc... | 10.1109/TPAMI.2023.3292363 | 37,405,895 | IEEE transactions on pattern analysis and machine intelligence | 2,023 | ||
Assessment of health utilities and quality of life in patients with non-alcoholic fatty liver disease. | BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease associated with increased liver-related mortality. Additionally, NAFLD could potentially impair health-related quality of life. Although an approved treatment for NAFLD does not exist, a number of new drugs fo... | 10.1136/bmjgast-2016-000106 | 27,648,297 | BMJ open gastroenterology | 2,016 | ||
Respiratory tract infections during the annual Hajj: potential risks and mitigation strategies. | PURPOSE OF REVIEW
Mass gatherings such as religious pilgrimages, sporting events and music concerts are becoming larger and more frequent. The scale and frequency of large-scale international events pose substantial risks to the spread of infectious diseases. The available literature on respiratory tract infections at ... | 10.1097/MCP.0b013e32835f1ae8 | 23,429,098 | D006801:Humans; D007251:Influenza, Human; D007514:Islam; D062486:Public Health Surveillance; D012141:Respiratory Tract Infections; D014195:Travel | Current opinion in pulmonary medicine | 2,013 | |
Transcatheter Aortic Valve Replacement Outcomes in Patients With Native vs Transplanted Kidneys: Data From an International Multicenter Registry. | BACKGROUND
Chronic kidney disease (CKD) has a negative impact on outcomes after transcatheter aortic valve replacement (TAVR). Data on outcomes in renal transplant recipients (RTRs) undergoing TAVR are scarce. We compared the outcomes in RTRs undergoing TAVR with matched patients who have native kidneys and similar kid... | 10.1016/j.cjca.2019.01.003 | 31,202,537 | D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve; D001024:Aortic Valve Stenosis; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D014943:Global Health; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D012042:Registries; D006435:Renal Dial... | The Canadian journal of cardiology | 2,019 | |
Demonstration and partial characterization of ecto-ATPase in Balamuthia mandrillaris and its possible role in the host-cell interactions. | AIMS
To investigate the presence and partial characterization of ecto-ATPase in Balamuthia mandrillaris.
METHODS AND RESULTS
In vitro assays were used to demonstrate that live B. mandrillaris hydrolyses extracellular AtP. Using nondenaturing polyacrylamide gel electrophoresis, B. mandrillaris exhibited a single ecto-... | 10.1111/j.1472-765X.2008.02414.x | 18,761,612 | D000251:Adenosine Triphosphatases; D000656:Amoeba; D000818:Animals; D000977:Antiparasitic Agents; D002448:Cell Adhesion; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D004591:Electrophoresis, Polyacrylamide Gel; D042783:Endothelial Cells; D006790:Host-Parasite Interactions; D006801:Humans; D010215:Papio; ... | Letters in applied microbiology | 2,008 | D000977:Antiparasitic Agents; D013498:Suramin; D010447:Peptide Hydrolases; D000251:Adenosine Triphosphatases; C027201:ectoATPase |
Expedition of Eudragit® Polymers in the Development of Novel Drug Delivery Systems. | Eudragit® polymer has been widely used in film-coating for enhancing the quality of products over other materials (e.g., shellac or sugar). Eudragit® polymers are obtained synthetically from the esters of acrylic and methacrylic acid. For the last few years, they have shown immense potential in the formulations of conv... | 10.2174/1567201817666200512093639 | 32,394,836 | D000284:Administration, Oral; D016503:Drug Delivery Systems; D006801:Humans; D011109:Polymethacrylic Acids | Current drug delivery | 2,020 | D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer |
Early classroom reading gains moderate shared environmental influences on reading comprehension in adolescence. | BACKGROUND
Reading is important for children's success in school and beyond, yet many adolescents fail to reach expected levels of proficiency. This highlights the need to better understand the factors that influence reading effectiveness over time, including genes and environment. Greater expression of genetic influen... | 10.1111/jcpp.13134 | 31,595,512 | D000293:Adolescent; D032882:Comprehension; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D007858:Learning; D008297:Male; D000297:Psychology, Adolescent; D011932:Reading; D012574:Schools; D014427:Twins | Journal of child psychology and psychiatry, and allied disciplines | 2,020 | |
Use of a novel imageless navigation system reduced fluoroscopy exposure and improved acetabular positioning in anterior approach total hip arthroplasty: a case-control study. | INTRODUCTION
Direct anterior approach (DAA) for total hip arthroplasty (THA) frequently utilizes fluoroscopy. The purpose of this study is to assess the impact of using a novel, imageless THA navigation system on radiation exposure and acetabular cup placement consistency.
MATERIALS AND METHODS
This was a retrospecti... | 10.1007/s00402-022-04520-3 | 35,776,176 | D006801:Humans; D019644:Arthroplasty, Replacement, Hip; D012189:Retrospective Studies; D016022:Case-Control Studies; D015331:Cohort Studies; D006622:Hip Prosthesis; D000077:Acetabulum; D005471:Fluoroscopy; D025321:Surgery, Computer-Assisted | Archives of orthopaedic and trauma surgery | 2,023 | |
Fructose content in popular beverages made with and without high-fructose corn syrup. | OBJECTIVE
Excess fructose consumption is hypothesized to be associated with risk for metabolic disease. Actual fructose consumption levels are difficult to estimate because of the unlabeled quantity of fructose in beverages. The aims of this study were threefold: 1) re-examine the fructose content in previously tested ... | 24,985,013 | D001628:Beverages; D004032:Diet; D019422:Dietary Sucrose; D005632:Fructose; D005638:Fruit; D005947:Glucose; D066248:High Fructose Corn Syrup; D006801:Humans; D013549:Sweetening Agents; D003313:Zea mays | Nutrition (Burbank, Los Angeles County, Calif.) | 2,014 | D019422:Dietary Sucrose; D066248:High Fructose Corn Syrup; D013549:Sweetening Agents; D005632:Fructose; D005947:Glucose | |
The effect of different nitrate preparations on plasma heparin concentrations and the activated partial thromboplastin time. | There is evidence that intravenous nitrates which are frequently used in acute coronary syndromes may interfere with the anticoagulant effect of heparin. We compared the effect of two different nitrate preparations on the activated partial thromboplastin time (APTT), anti-thrombin III activity (AT III) and plasma hepar... | 10.1136/pgmj.70.820.100 | 8,170,877 | D000787:Angina Pectoris; D015906:Angioplasty, Balloon, Coronary; D000990:Antithrombin III; D005260:Female; D006493:Heparin; D006494:Heparin Antagonists; D006801:Humans; D007548:Isosorbide Dinitrate; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin; D010314:Partial Thromboplastin Time | Postgraduate medical journal | 1,994 | D006494:Heparin Antagonists; D000990:Antithrombin III; D006493:Heparin; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate |
Can radiomics features be reproducibly measured from CBCT images for patients with non-small cell lung cancer? | PURPOSE
Increasing evidence suggests radiomics features extracted from computed tomography (CT) images may be useful in prognostic models for patients with nonsmall cell lung cancer (NSCLC). This study was designed to determine whether such features can be reproducibly obtained from cone-beam CT (CBCT) images taken usi... | 10.1118/1.4934826 | 26,632,036 | D002289:Carcinoma, Non-Small-Cell Lung; D054893:Cone-Beam Computed Tomography; D006801:Humans; D009038:Motion; D019047:Phantoms, Imaging; D018514:Plant Structures; D013902:Radiography, Thoracic; D015203:Reproducibility of Results; D012119:Respiration; D012189:Retrospective Studies; D012408:Rubber | Medical physics | 2,015 | D012408:Rubber |
A novel homozygous LMNA mutation (p.Met540Ile) causes mandibuloacral dysplasia type A. | Mandibuloacral dysplasia with type A lipodystrophy (MADA) is a rare genetic disorder inherited in an autosomal recessive fashion characterized by hypoplasia of the mandible and clavicles, acroosteolysis and lipodystrophy due to mutations in the LMNA or ZMPSTE24 genes. In the current study, we have investigated a consan... | 26,602,028 | D000015:Abnormalities, Multiple; D030981:Acro-Osteolysis; D000293:Adolescent; D000595:Amino Acid Sequence; D003241:Consanguinity; D006720:Homozygote; D006801:Humans; D007492:Iran; D034904:Lamin Type A; D008060:Lipodystrophy; D008297:Male; D008334:Mandible; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D0... | Gene | 2,016 | C494847:LMNA protein, human; D034904:Lamin Type A | |
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers. | BACKGROUND
Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia mutated and rad3 related (ATR) and DNA-dependent protein kinase catalytic sub-unit (DNA-PKcs) play critical roles in DNA damage response (DDR) by linking DNA damage sensing to DDR effectors that regulate cell cycle progression and DNA repair. Our obj... | 10.1016/j.bbacli.2014.08.001 | 26,674,120 | BBA clinical | 2,014 | ||
A randomized phase III trial comparing S-1 versus UFT as adjuvant chemotherapy for stage II/III rectal cancer (JFMC35-C1: ACTS-RC). | BACKGROUNDS
Preventing distant recurrence and achieving local control are important challenges in rectal cancer treatment, and use of adjuvant chemotherapy has been studied. However, no phase III study comparing adjuvant chemotherapy regimens for rectal cancer has demonstrated superiority of a specific regimen. We ther... | 10.1093/annonc/mdw162 | 27,056,996 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms; D018572:Disease-Free Survival; D004338:Drug Combinations; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D0... | Annals of oncology : official journal of the European Society for Medical Oncology | 2,016 | D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D014498:Uracil; D010094:Oxonic Acid |
Clinical features and treatment outcomes of visceral leishmaniasis patients admitted to three centers in Oromia, Ethiopia. | INTRODUCTION
In three health care facilities in the Oromia region, the aim of this study is to report on 1) the number of VL cases registered over time (2013-2018) and 2) the clinical profile, type of treatment used and response to treatment.
METHODOLOGY
A retrospective cohort study was conducted among all VL cases a... | 10.3855/jidc.11731 | 32,614,795 | D000293:Adolescent; D000981:Antiprotozoal Agents; D002648:Child; D002675:Child, Preschool; D005002:Ethiopia; D005260:Female; D006268:Health Facilities; D006801:Humans; D007898:Leishmaniasis, Visceral; D008297:Male; D036301:Qualitative Research; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcom... | Journal of infection in developing countries | 2,020 | D000981:Antiprotozoal Agents |
lncRNA TUG1 promotes proliferation and differentiation of osteoblasts by regulating the miR-545-3p/CNR2 axis. | Osteoblast differentiation is an effective way to promote bone formation. Long non-coding RNA taurine upregulated 1 (TUG1) has been identified as a crucial modulator of multiple biological processes. This study was designed to investigate the function of TUG1 in the proliferation and differentiation of osteoblast precu... | 10.1590/1414-431X20209798 | 33,053,117 | D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D035683:MicroRNAs; D010006:Osteoblasts; D062085:RNA, Long Noncoding; D043885:Receptor, Cannabinoid, CB2; D013654:Taurine | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas | 2,020 | C588309:CNR2 protein, human; C000594767:MIR545 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D043885:Receptor, Cannabinoid, CB2; C000598536:TUG1 long noncoding RNA, human; D013654:Taurine |
Status epilepticus after ligation of portosystemic shunts. | Status epilepticus developed in four dogs, 2 to 3 days after ligation of an extrahepatic portosystemic shunt. Pentobarbital or phenobarbital intravenously was required to control seizure activity. Two dogs treated with phenobarbital recovered. Exacerbation of hepatic encephalopathy secondary to metabolic changes after ... | 10.1111/j.1532-950x.1990.tb01224.x | 2,264,277 | D000818:Animals; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D008026:Ligation; D008297:Male; D010424:Pentobarbital; D010634:Phenobarbital; D011168:Portal System; D011183:Postoperative Complications; D013226:Status Epilepticus; D013577:Syndrome | Veterinary surgery : VS | 1,990 | D010424:Pentobarbital; D010634:Phenobarbital |
Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. | Procyanidins present in grape seeds are known to exert anti-inflammatory, anti-arthritic and anti-allergic activities, prevent skin aging, scavenge oxygen free radicals and inhibit UV radiation-induced peroxidation activity. Since most of these events are associated with the tumor promotion stage of carcinogenesis, the... | 10.1093/carcin/20.9.1737 | 10,469,619 | D015127:9,10-Dimethyl-1,2-benzanthracene; D000096:Acetone; D000279:Administration, Cutaneous; D000818:Animals; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D001205:Ascorbic Acid; D044946:Biflavonoids; D002392:Catechin; D003043:Cocarcinogenesis; D004817:Epidermis; D005260:Female; D005419:Flavonoids; D015227:Li... | Carcinogenesis | 1,999 | D016588:Anticarcinogenic Agents; D000975:Antioxidants; D044946:Biflavonoids; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D044945:Proanthocyanidins; C479586:procyanidin B5 3'-O-gallate; C121404:procyanidin B5-3'-gallate; D000096:Acetone; D014810:Vitamin E; C479580:procyanidin B2; D0151... |
Comorbid renal tubular damage and hypoalbuminemia exacerbate cardiac prognosis in patients with chronic heart failure. | BACKGROUND
Renal tubular damage (RTD) and hypoalbuminemia are risks for poor prognosis in patients with chronic heart failure (CHF). Renal tubules play a pivotal role in amino acid and albumin reabsorption, which maintain serum albumin levels. The aims of the present study were to (1) examine the association of RTD wit... | 10.1007/s00392-015-0899-z | 26,220,048 | D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002908:Chronic Disease; D003404:Creatinine; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure; D006801:Humans; D034141:Hypoalbuminemia; D007674:Kidney Diseases; D007684:Kidney Tubules; D008297:Male; D008875:Middle Aged; D015999:Multivariate An... | Clinical research in cardiology : official journal of the German Cardiac Society | 2,016 | D015415:Biomarkers; D003404:Creatinine |
Diaphragmatic coronary lesion mimics significant coronary stenosis: a report of four cases. | Diaphragmatic coronary stenosis is a rare coronary angiographic finding. It gives rise to an appearance of relatively severe obstruction and can lead to unnecessary surgical intervention or PTCA. We described four patients with this type of stenosis in whom the lesions proved to be hemodynamically insignificant as judg... | 10.1002/ccd.1810110209 | 3,157,457 | D000328:Adult; D000368:Aged; D000792:Angiography; D000800:Angioplasty, Balloon; D003251:Constriction, Pathologic; D017023:Coronary Angiography; D003327:Coronary Disease; D003937:Diagnosis, Differential; D003964:Diaphragm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged | Catheterization and cardiovascular diagnosis | 1,985 | |
High fertility using artificial insemination during deep anoestrus after induction and synchronisation of ovulatory activity by the "male effect" in lactating goats subjected to treatment with artificial long days and progestagens. | The response to the male effect was studied in two Saânen and two Alpine flocks over 5 consecutive years. Adult male and female goats were exposed to artificial long days (16h light and 8h darkness, 16L:8D) in open barns for approximately 3 months (between December 1 and April 15) followed by a natural photoperiod. Goa... | 10.1016/j.anireprosci.2007.11.026 | 18,178,043 | D000818:Animals; D015925:Cryopreservation; D003624:Darkness; D005260:Female; D005298:Fertility; D003425:Flurogestone Acetate; D005602:France; D006041:Goats; D007315:Insemination, Artificial; D008027:Light; D008297:Male; D010053:Ovary; D010062:Ovulation Induction; D010507:Periodicity; D017440:Photoperiod; D011374:Proges... | Animal reproduction science | 2,008 | D011372:Progestins; D011374:Progesterone; D003425:Flurogestone Acetate |
Treatment Adherence And Persistence Among HIV-1 Patients Newly Starting Treatment. | OBJECTIVE
To assess adherence and persistence with first-line single-tablet regimen (STR) and multi-tablet regimen (MTR) antiretroviral therapy (ART) in newly treated HIV-1 patients.
METHODS
Retrospective analysis of longitudinal pharmacy claims among US patients initiating ART between 1/1/2016 and 5/31/2016 (index d... | 10.2147/PPA.S207908 | 31,806,941 | Patient preference and adherence | 2,019 | ||
Diverse migration strategies in hoopoes (Upupa epops) lead to weak spatial but strong temporal connectivity. | The annual cycle of migrating birds is shaped by their seasonal movements between breeding and non-breeding sites. Studying how migratory populations are linked throughout the annual cycle-migratory connectivity, is crucial to understanding the population dynamics of migrating bird species. This requires the considerat... | 10.1007/s00114-018-1566-9 | 29,931,450 | D025041:Animal Migration; D000818:Animals; D001717:Birds; D005060:Europe; D011157:Population Dynamics | Die Naturwissenschaften | 2,018 | |
The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression. | The engrailed locus plays a unique and critical role in organizing the segmented body plan of Drosophila. Embryos lacking engrailed function die with fused, abnormal segments. Adult mosaics with patches of engrailed cells similarly suffer defects in all of their segments, but only with mutant cells that are in the post... | 10.1016/0092-8674(85)90307-1 | 3,917,856 | D000818:Animals; D002874:Chromosome Mapping; D004331:Drosophila melanogaster; D005796:Genes; D009030:Mosaicism; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D014158:Transcription, Genetic | Cell | 1,985 | |
A nurse's guide to mental health assessment reference sources. | 1. As the research base on psychological testing has proliferated across various disciplines, a comprehensive review of the testing literature is recommended. 2. In researching literature on psychological tests, nurses need to rely on traditional print as well as electronic databases and Internet sites. 3. In reviewing... | 10.3928/0279-3695-20000201-09 | 10,693,112 | D004509:Education, Nursing, Continuing; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D001523:Mental Disorders; D009730:Nursing Assessment; D010506:Periodicals as Topic; D011568:Psychiatric Nursing; D011581:Psychological Tests | Journal of psychosocial nursing and mental health services | 2,000 | |
Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats. | BACKGROUND
Endothelial dysfunction is a key process in atherosclerosis. Hypomethylation is one of the postulated mechanisms involved in atherogenesis and is mainly secondary to a decrease in essential factors such as, folate and vitamin B12 for the biosynthesis of S-adenosylmethionine (SAM), the main methyl-group donor... | 10.1016/j.clnu.2008.08.010 | 18,845,366 | D000109:Acetylcholine; D000818:Animals; D001013:Aorta, Thoracic; D050197:Atherosclerosis; D004730:Endothelium, Vascular; D005494:Folic Acid Deficiency; D006710:Homocysteine; D066298:In Vitro Techniques; D008099:Liver; D008297:Male; D008745:Methylation; D020030:Nitric Oxide Donors; D009599:Nitroprusside; D051381:Rats; D... | Clinical nutrition (Edinburgh, Scotland) | 2,008 | D020030:Nitric Oxide Donors; D006710:Homocysteine; D009599:Nitroprusside; D012436:S-Adenosylmethionine; D000109:Acetylcholine; D014805:Vitamin B 12 |
The role of phosphorylation in synucleinopathies: focus on Parkinson's disease. | Synuclein is a soluble, natively unfolded protein that is highly enriched in the presynaptic terminals of neurons in the central nervous system. Interest in -synuclein has increased markedly following the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson's d... | 10.2174/187152710791556140 | 20,522,010 | D000818:Animals; D030801:Animals, Genetically Modified; D004331:Drosophila melanogaster; D006801:Humans; D016631:Lewy Bodies; D010300:Parkinson Disease; D010766:Phosphorylation; D051843:Synucleins; D051844:alpha-Synuclein | CNS & neurological disorders drug targets | 2,010 | D051843:Synucleins; D051844:alpha-Synuclein |
MUC1 splice variants in human ocular surface tissues: possible differences between dry eye patients and normal controls. | Mucins are highly glycosylated proteins that are vital to the maintenance of healthy epithelial surfaces including the ocular surface. Mucins act as lubricants, protectants, and mediators of signal transduction. The majority of the O-glycosylation sites on the transmembrane mucin MUC1 are found in a highly polymorphic ... | 10.1016/j.exer.2006.01.031 | 16,631,167 | D017398:Alternative Splicing; D000595:Amino Acid Sequence; D016022:Case-Control Studies; D003228:Conjunctiva; D015352:Dry Eye Syndromes; D006801:Humans; D008969:Molecular Sequence Data; D018396:Mucin-1; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase ... | Experimental eye research | 2,006 | D018396:Mucin-1 |
The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes. | The aim of this study was to identify single nucleotide variants in genes associated with susceptibility to or severe outcomes of COVID-19. A total of 319 genomic DNA samples from patients with varying degrees of disease severity and 78 control DNA samples from people who had regular or prolonged contact with patients ... | 10.3390/biomedicines10030549 | 35,327,350 | Biomedicines | 2,022 | ||
Genotypic variation and antifungal susceptibilities of Candida pelliculosa clinical isolates. | At the Istituto Ricovero Cura Carattere Scientifico, Ospedale Maggiore di Milano, Italy, Candida pelliculosa accounted for 3.3 and 4.4 % of all Candida species other than Candida albicans collected during 1996 and 1998, respectively. Genetic variability was investigated by electrophoretic karyotyping and inter-repeat P... | 10.1099/jmm.0.45850-0 | 15,713,612 | D000935:Antifungal Agents; D002175:Candida; D002177:Candidiasis; D004271:DNA, Fungal; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007558:Italy; D007621:Karyotyping; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction | Journal of medical microbiology | 2,005 | D000935:Antifungal Agents; D004271:DNA, Fungal |
Energetics of metamorphic climax in the pickerel frog (Lithobates palustris). | Anuran metamorphosis, the transition from aquatic larvae to terrestrial juveniles, is accompanied by significant morphological, physiological, and behavioral changes. Timing of metamorphosis and final size, which can influence adult fitness, may depend on sufficient energy accumulated during the larval period to suppor... | 10.1016/j.cbpa.2009.06.001 | 19,508,896 | D000818:Animals; D001835:Body Weight; D004734:Energy Metabolism; D007814:Larva; D008675:Metamorphosis, Biological; D010101:Oxygen Consumption; D011898:Ranidae; D013997:Time Factors | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology | 2,009 | |
Preparation of human albumin solder for laser tissue welding. | Previous studies have demonstrated that the addition of a protein solder to augment the laser tissue weld significantly improves postoperative results. Herein we describe a method for the preparation of human albumin for use as a laser tissue solder. We also review the brief history of laser tissue solders and discuss ... | 10.1002/lsm.1900130514 | 8,264,331 | D000818:Animals; D006801:Humans; D053685:Laser Therapy; D011817:Rabbits; D012709:Serum Albumin; D014014:Tissue Adhesives | Lasers in surgery and medicine | 1,993 | D012709:Serum Albumin; D014014:Tissue Adhesives |
Uremic toxin indoxyl 3-sulfate regulates the differentiation of Th2 but not of Th1 cells to lessen allergic asthma. | Immune system dysfunctions including the increased Th1/Th2 ratio are common in chronic kidney disease (CKD) patients, and a wide variety of skin diseases including Th1-mediated uremic pruritis are associated with CKD. Although there are more than 90 uremic toxins reported, it is yet to be known which uremic solute is a... | 24,291,743 | D000818:Animals; D001249:Asthma; D051792:Basic Helix-Loop-Helix Transcription Factors; D001571:Benzoflavones; D001992:Bronchoalveolar Lavage Fluid; D002454:Cell Differentiation; D002478:Cells, Cultured; D004195:Disease Models, Animal; D007073:Immunoglobulin E; D007200:Indican; D015847:Interleukin-4; D008297:Male; D0513... | Toxicology letters | 2,014 | C484722:Ahr protein, mouse; D051792:Basic Helix-Loop-Helix Transcription Factors; D001571:Benzoflavones; D018336:Receptors, Aryl Hydrocarbon; D050799:STAT5 Transcription Factor; D050800:STAT6 Transcription Factor; C494100:Stat6 protein, mouse; D015847:Interleukin-4; D007073:Immunoglobulin E; C011512:alpha-naphthoflavon... | |
Color of fresh, frozen and cooked ground beef patties manufactured with mechanically recovered neck bone lean. | Mechanical systems that recover lean tissue from beef vertebrae without grinding bone material are in use in major packing plants across the country. Our objective was to determine the effects of mechanically recovered neck bone lean (MRNL) on color stability of fresh, frozen and cooked ground beef patties. Ground beef... | 10.1016/0309-1740(95)00046-1 | 22,060,892 | Meat science | 1,996 | ||
Periostin is a negative regulator of mineralization in the dental pulp tissue. | The dental pulp tissue is encased in hard tissue and surrounded by hard tissue-forming cells, but remains in a non-mineralized state itself, suggesting the presence of regulatory mechanisms precluding pulp mineralization. This study aimed to reveal the regulatory function of periostin (Postn), which is essential for os... | 10.1007/s10266-014-0152-7 | 24,647,621 | D000469:Alkaline Phosphatase; D000818:Animals; D015153:Blotting, Western; D015815:Cell Adhesion Molecules; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D003782:Dental Pulp; D015536:Down-Regulation; D007124:Immunoenzyme Techniques; D008297:Male; D008813:Mice, Inbred ICR; D009804:Odo... | Odontology | 2,015 | D015815:Cell Adhesion Molecules; C082838:Postn protein, mouse; D051880:Receptors, Notch; D000469:Alkaline Phosphatase |
Patterns of drug use in Castille and Leon (Spain). | A total of 2500 individuals, aged 14-70 years and living in Castille and Leon (Spain), were surveyed in the spring of 1989 with regard to their drug consumption and patterns of use. 'Lifetime' drug users' rates were 30.0% for cannabis, 5.4% for cocaine, 5.2% for amphetamines, 2.4% for psychedelic drugs, 1.5% for opiate... | 10.1111/j.1360-0443.1992.tb02002.x | 1,511,229 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D013287:Illicit Drugs; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs; D012907:Smoking; D013030:Spain; D019966:Substa... | British journal of addiction | 1,992 | D013287:Illicit Drugs; D011619:Psychotropic Drugs |
Changes in the small noncoding RNA transcriptome in osteosarcoma cells. | BACKGROUND
Osteosarcoma has the highest incidence among bone malignant tumors and mainly occurs in adolescents and the elderly, but the pathological mechanism is still unclear, which makes early diagnosis and treatment very difficult. Bone marrow mesenchymal stem cells (BMSCs) are considered to be one of the sources of... | 10.1186/s13018-023-04362-8 | 38,001,513 | D006801:Humans; D000293:Adolescent; D000368:Aged; D058727:RNA, Small Untranslated; D059467:Transcriptome; D035683:MicroRNAs; D012516:Osteosarcoma | Journal of orthopaedic surgery and research | 2,023 | D058727:RNA, Small Untranslated; D035683:MicroRNAs |
[Importance of determining hydrogen peroxide in expired air in the evaluation of oxidative lung damage]. | Classical methods of respiratory diagnosis were extended with methods allowing determination of the metabolic products from lung tissue--the biochemical analysis of expired air. Hydrogen peroxide is one of the substances used as markers of pathological processes in the respiratory system. This review describes position... | 12,841,120 | D015415:Biomarkers; D001944:Breath Tests; D006801:Humans; D006861:Hydrogen Peroxide; D008171:Lung Diseases; D018384:Oxidative Stress | Casopis lekaru ceskych | 2,003 | D015415:Biomarkers; D006861:Hydrogen Peroxide | |
Prevalence and antimicrobial resistance of Campylobacter isolates in broilers from China. | The prevalence and antimicrobial resistance of Campylobacter spp. in broiler chickens were determined in Shandong Province, China. In total, 275 Campylobacter isolates were obtained from 767 broiler cecal samples, including 208 Campylobacter jejuni, 53 Campylobacter coli, and 14 unidentified Campylobacter isolates. Min... | 10.1016/j.vetmic.2009.12.035 | 20,116,182 | D000818:Animals; D000900:Anti-Bacterial Agents; D002167:Campylobacter; D002169:Campylobacter Infections; D017000:Campylobacter coli; D016123:Campylobacter jejuni; D002645:Chickens; D002681:China; D017931:DNA Primers; D004352:Drug Resistance, Microbial; D005784:Gene Amplification; D011201:Poultry Diseases; D012335:RNA, ... | Veterinary microbiology | 2,010 | D000900:Anti-Bacterial Agents; D017931:DNA Primers; D012335:RNA, Ribosomal |
[Ogilvie's syndrome following cesarean section. Apropos of a case]. | The authors report a case of post-caesarian acute idiopathic dilatation of the colon (Ogilvie's syndrome), which is a rare syndrome, particularly after caesarian section, which poses difficult diagnostic problems. The most serious complication consists of perforation of the caecum. The pathogenesis of this syndrome is ... | 6,528,174 | D000328:Adult; D002585:Cesarean Section; D003108:Colonic Diseases; D003974:Diatrizoate Meglumine; D004108:Dilatation, Pathologic; D005260:Female; D006801:Humans; D007440:Intubation; D011247:Pregnancy; D011644:Puerperal Disorders; D011859:Radiography | Revue francaise de gynecologie et d'obstetrique | 1,984 | D003974:Diatrizoate Meglumine | |
Notch and disease: a growing field. | Signals through the Notch receptors are used throughout development to control cellular fate choices. Our intention here is to provide an overview of the involvement of Notch signaling in human disease, which, keeping pace with the known biology of the pathway, manifests itself in a pleiotropic fashion. A pathway with ... | 10.1016/j.semcdb.2012.02.005 | 22,373,641 | D016738:Alagille Syndrome; D000818:Animals; D001851:Bone Diseases, Metabolic; D046589:CADASIL; D002318:Cardiovascular Diseases; D058685:Genetic Pleiotropy; D006801:Humans; D009154:Mutation; D009369:Neoplasms; D009857:Oncogenes; D051880:Receptors, Notch; D015398:Signal Transduction | Seminars in cell & developmental biology | 2,012 | D051880:Receptors, Notch |
Cancer clusters in the USA: what do the last twenty years of state and federal investigations tell us? | BACKGROUND
Cancer clusters garner considerable public and legislative attention, and there is often an expectation that cluster investigations in a community will reveal a causal link to an environmental exposure. At a 1989 national conference on disease clusters, it was reported that cluster studies conducted in the 1... | 10.3109/10408444.2012.675315 | 22,519,802 | D016000:Cluster Analysis; D004781:Environmental Exposure; D015340:Epidemiologic Research Design; D006801:Humans; D015994:Incidence; D009369:Neoplasms; D014481:United States | Critical reviews in toxicology | 2,012 | |
Adolescents have unfavorable opinions of adolescents who use e-cigarettes. | INTRODUCTION
While evidence suggests positive opinions of smokers are associated with tobacco use, research exploring adolescents' opinions of e-cigarette users is nascent. We hypothesized that adolescents harbor positive opinions of e-cigarette users, and that these opinions will be more positive among adolescents wil... | 10.1371/journal.pone.0206352 | 30,403,731 | D000293:Adolescent; D001290:Attitude; D066300:Electronic Nicotine Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D013334:Students; D011795:Surveys and Questionnaires | PloS one | 2,018 | |
Animal protein-free OptiXcell and shortened equilibration periods can replace egg yolk-based extender and slow cooling for rhinoceros semen cryopreservation. | OptiXcell (OP) was tested as an animal protein-free alternative to an egg yolk-based extender for rhinoceros semen cryopreservation and shorter chilling/equilibration periods were evaluated. Semen was collected from three rhinoceros species: black (Diceros bicornis; n = 2), white (Ceratotherium simum; n = 2), and great... | 10.1016/j.cryobiol.2019.06.003 | 31,226,254 | D000818:Animals; D002462:Cell Membrane; D003080:Cold Temperature; D015925:Cryopreservation; D003451:Cryoprotective Agents; D004530:Egg Yolk; D006736:Horses; D008297:Male; D012661:Semen; D055101:Semen Analysis; D012662:Semen Preservation; D013081:Sperm Motility; D013094:Spermatozoa | Cryobiology | 2,019 | D003451:Cryoprotective Agents |
DDT & deltamethrin resistance status of known Japanese encephalitis vectors in Assam, India. | BACKGROUND & OBJECTIVE
Japanese encephalitis (JE) outbreaks are common in Assam, northeastern State of India. Information on resistance in known JE vectors in the affected area is important for effective control measures. This study was undertaken to determine the species abundance of JE vectors endemic to Sibsagar dis... | 24,521,646 | D000818:Animals; D009033:Culicidae; D003634:DDT; D004672:Encephalitis, Japanese; D005260:Female; D006801:Humans; D007194:India; D007303:Insect Vectors; D007305:Insecticide Resistance; D009570:Nitriles; D011722:Pyrethrins; D013045:Species Specificity | The Indian journal of medical research | 2,013 | D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D003634:DDT | |
Response of mouse splenic lymphocytes to timothy pollen antigens in a microculture system. | Spleen cells from LAF1 mice were stimulated in a microculture system with T and B cell mitogens or antigens of timothy pollen. Only cells from mice immunized with crude timothy pollen extract (WST) or a major antigen of timothy pollen conjugated to Ascaris (antigen B-Ascaris) responded to timothy antigens in vitro. Opt... | 1,184,966 | D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D007114:Immunization; D008213:Lymphocyte Activation; D051379:Mice; D008934:Mitogens; D006109:Poaceae; D011058:Pollen; D013154:Spleen; D013997:Time Factors | Journal of immunology (Baltimore, Md. : 1950) | 1,975 | D000941:Antigens; D008934:Mitogens | |
Clinical application of the ventricular assist devices in Japan. | From 1980 to March in 1989, there were 177 clinical application of ventricular assist device in Japan. Original diseases were 50% ischemic heart disease and 37% valvular disease. Duration of assistance ranged from one hour to 70 days. Thirty-one cases weaned from ventricular assistance and 11 cases became long-time sur... | 1,749,927 | D002423:Cause of Death; D006352:Heart Ventricles; D006353:Heart-Assist Devices; D006801:Humans; D007564:Japan | The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku | 1,991 | ||
Cholesterol, cholesterol-lowering agents/statins, and urologic disease: Part V--Statins versus aspirin for primary prevention, and the winner is...? | There are no national guidelines when comparing an aspirin daily to a statin drug in individuals with no history of a cardiovascular event (primary prevention). However, recent reviews of the medical clinical research on statins and aspirin for preventing a first coronary heart disease (CHD) event concluded that compar... | 17,494,461 | D001241:Aspirin; D002318:Cardiovascular Diseases; D002423:Cause of Death; D016527:Drug Costs; D019317:Evidence-Based Medicine; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006937:Hypercholesterolemia; D010353:Patient Education as Topic; D018579:Patient Selection; D010975:Platelet Aggregation... | Urologic nursing | 2,007 | D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin | |
Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts. | A tissue microarray (TMA) has previously been developed for use in assessment of neurodegenerative diseases. We investigated the variation of pathology loads in semi-quantitative score categories and how pathology load related to disease progression. Post-mortem tissue from 146 cases were used; Alzheimer's disease (AD)... | 10.1007/s00702-017-1702-2 | 28,265,813 | D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides; D001921:Brain; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020961:Lewy Body Disease; D008297:Male; D016874:Neurofibrillary Tangles; D010363:Pattern Recognition, Automated; D010766:Phosphorylation; D0127... | Journal of neural transmission (Vienna, Austria : 1996) | 2,017 | D016229:Amyloid beta-Peptides; C054369:MAPT protein, human; C497604:SNCA protein, human; D051844:alpha-Synuclein; D016875:tau Proteins |
Association between single-nucleotide polymorphisms and adverse events in nivolumab-treated non-small cell lung cancer patients. | BACKGROUND
Treatment with PD-1 inhibitors can be hampered by severe auto-immune-related toxicities. Our objective was to identify single-nucleotide polymorphisms (SNPs) in genes previously associated with auto-immunity, which are associated with toxicities in nivolumab-treated NSCLC patients. This was in order to ident... | 10.1038/s41416-018-0074-1 | 29,695,768 | D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D000077594:Nivolumab; D020641:Polymorphism, Single Nucleotide; D061026:Program... | British journal of cancer | 2,018 | D009363:Neoplasm Proteins; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D000077594:Nivolumab |
Device-Related Complications and Inappropriate Therapies Among Subcutaneous vs. Transvenous Implantable Defibrillator Recipients: Insight Monaldi Rhythm Registry. | Introduction
In the context of randomized clinical trials, subcutaneous implantable cardiac defibrillators (S-ICDs) are non-inferior to transvenous ICDs (T-ICDs) concerning device-related complications or inappropriate shocks in patients with an indication for defibrillator therapy and not in need of pacing. We aimed a... | 10.3389/fcvm.2022.879918 | 35,651,910 | Frontiers in cardiovascular medicine | 2,022 | ||
Negative affectivity and intellectual ability: a study of their relation to self-reported physical symptoms, perceived daily stress and mood, and disciplinary problems in military recruits. | In this study we examined the relationship between cognitive ability and Negative Affectivity (NA) (measured as cognitive and behavioral aspects of anxiety) on the one hand, and somatic complaints, symptom attribution (i.e. subjective evaluation of psychological vs somatic symptom causes), perceived daily stress/mood, ... | 10.1016/0277-9536(94)90101-5 | 7,973,858 | D000223:Adaptation, Psychological; D000328:Adult; D001007:Anxiety; D001076:Aptitude; D001294:Attitude to Health; D003863:Depression; D006801:Humans; D007360:Intelligence; D008297:Male; D008889:Military Personnel; D009042:Motivation; D010555:Personality Inventory; D012925:Social Conformity; D013001:Somatoform Disorders;... | Social science & medicine (1982) | 1,994 | |
Portable microfluidic impedance biosensor for SARS-CoV-2 detection. | Pandemics as the one we are currently facing, where fast-spreading viruses present a threat to humanity, call for simple and reliable methods to perform early diagnosis, enabling detection of very low pathogen loads even before symptoms start showing in the host. So far, standard polymerase chain reaction (PCR) is the ... | 10.1016/j.bios.2023.115362 | 37,300,901 | D006801:Humans; D000086402:SARS-CoV-2; D000086382:COVID-19; D044085:Microfluidics; D017097:Electric Impedance; D015203:Reproducibility of Results; D015374:Biosensing Techniques | Biosensors & bioelectronics | 2,023 | |
Linderalides A-D, Disesquiterpenoid-Geranylbenzofuranone Conjugates from Lindera aggregata. | Four disesquiterpenoid-geranylbenzofuranone conjugates, linderalides A-D (1-4), were isolated from Lindera aggregata. Compounds 1-3 represent the first examples of disesquiterpenoid-geranylbenzofuranone hybrids directly linked by two C-C bonds. Linderalide D (4) bears an unprecedented carbon skeleton featuring an unusu... | 10.1021/acs.joc.9b00522 | 31,135,158 | D001572:Benzofurans; D027443:Lindera; D018517:Plant Roots; D012717:Sesquiterpenes; D013237:Stereoisomerism | The Journal of organic chemistry | 2,019 | D001572:Benzofurans; D012717:Sesquiterpenes; C105430:benzofuran |
Diagnostic accuracy of rapid diagnostic tests for the early detection of leptospirosis. | BACKGROUND
Leptospirosis is often misdiagnosed with several other tropical febrile illnesses in Malaysia due to similarities in clinical manifestations. Although treatment regimens could be started based on clinical judgments, early diagnosis has become paramount as a guide to chemotherapeutic interventions. Confirmed ... | 10.1016/j.jiph.2018.10.137 | 30,502,041 | D000907:Antibodies, Bacterial; D003955:Diagnostic Tests, Routine; D042241:Early Diagnosis; D006801:Humans; D007118:Immunoassay; D007075:Immunoglobulin M; D007922:Leptospirosis; D008296:Malaysia; D000067716:Point-of-Care Testing; D011446:Prospective Studies; D012680:Sensitivity and Specificity | Journal of infection and public health | 2,019 | D000907:Antibodies, Bacterial; D007075:Immunoglobulin M |
Cholinergic-induced HCO3- loss from rat parotid acini. | The effect of cholinergic stimulation on the magnitude of anion loss from collagenase-isolated rat parotid acini suspended in a Krebs-Ringer bicarbonate buffer was characterized by means of 36Cl. It was found that on stimulation, the acinar Cl- concentration decreases from 62.3 mM to 22.6 mM in about 10 seconds after a... | 2,534,564 | D000818:Animals; D000838:Anions; D001639:Bicarbonates; D001693:Biological Transport, Active; D002217:Carbachol; D002712:Chlorides; D006863:Hydrogen-Ion Concentration; D007474:Ion Exchange; D008297:Male; D010306:Parotid Gland; D051381:Rats; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D013268:... | Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia | 1,989 | D000838:Anions; D001639:Bicarbonates; D002712:Chlorides; D002217:Carbachol | |
Gestures for Picture Archiving and Communication Systems (PACS) operation in the operating room: Is there any standard? | OBJECTIVE
Gestural interfaces allow accessing and manipulating Electronic Medical Records (EMR) in hospitals while keeping a complete sterile environment. Particularly, in the Operating Room (OR), these interfaces enable surgeons to browse Picture Archiving and Communication System (PACS) without the need of delegating... | 10.1371/journal.pone.0198092 | 29,894,481 | D002983:Clinical Competence; D057286:Electronic Health Records; D005868:Gestures; D006801:Humans; D009068:Movement; D000069471:Neurosurgeons; D009873:Operating Rooms; D011873:Radiology Information Systems; D012984:Software; D014584:User-Computer Interface | PloS one | 2,018 | |
Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis. | BACKGROUND
The aim of the study was to assess a panel of promising biomarkers for their ability to improve diagnosis of sporadic amyotrophic lateral sclerosis (ALS).
METHODS
Forty patients with sporadic ALS and 40 controls with other neurological diseases were evaluated. Levels of phosphorylated neurofilament heavy c... | 10.1186/s12883-016-0689-x | 27,634,542 | D000690:Amyotrophic Lateral Sclerosis; D015415:Biomarkers; D016022:Case-Control Studies; D055316:Cystatin C; D018450:Disease Progression; D005260:Female; D006596:Hexosaminidases; D006801:Humans; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins; D010766:Phosphorylation; D011237:Predictive Value of Tests... | BMC neurology | 2,016 | D015415:Biomarkers; D055316:Cystatin C; D016900:Neurofilament Proteins; D064568:S100 Calcium Binding Protein beta Subunit; C051774:neurofilament protein H; D006596:Hexosaminidases; C086400:chitotriosidase |
Hereditary myoclonus and chorea: the spectrum of hereditary nonprogressive hyperkinetic movement disorders. | We report three members of a single family who developed a newly described combination of myoclonus and chorea in association with mild ataxia. The occurrence of this and related syndromes suggests that inherited, slowly progressive myoclonus, chorea, and dystonia, alone or in combination, should be viewed as a spectru... | 10.1002/mds.870020407 | 3,504,555 | D000328:Adult; D002819:Chorea; D004421:Dystonia; D005260:Female; D005500:Follow-Up Studies; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus | Movement disorders : official journal of the Movement Disorder Society | 1,987 | |
Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin. | Here we describe the basic features of the interaction of K+ channels with Pi1, a recently described 35 amino acid scorpion toxin, which has four disulfide bridges instead of the three commonly found in all the other known scorpion toxins. We found that: (a) Pi1 blocks ShakerB from the outside with a 1:1 stoichiometry,... | 10.1016/s0014-5793(96)01387-7 | 9,001,397 | D000818:Animals; D002412:Cations; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D010455:Peptides; D012604:Scorpion Venoms; D012605:Scorpions; D051637:Shaker Superfamily of Potassium Channels; D012964:Sodium; D018411:Spodoptera | FEBS letters | 1,997 | D002412:Cations; D010455:Peptides; D012604:Scorpion Venoms; C076413:Shaker B potassium channel polypeptide; D051637:Shaker Superfamily of Potassium Channels; D012964:Sodium |
An immunohistochemical evaluation of the proteins Wnt1 and glycogen synthase kinase (GSK)-3β in invasive breast carcinomas. | AIMS
Our purpose was to investigate, in breast carcinomas, the prognostic importance of the proteins Wnt1 and glycogen synthasekinase (GSK)-3β, and their associations with classic clinicopathological indices.
METHODS AND RESULTS
Immunohistochemistry was performed on paraffin-embedded tissue specimens from 288 invasiv... | 10.1111/his.12095 | 23,551,536 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms; D018270:Carcinoma, Ductal, Breast; D018275:Carcinoma, Lobular; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D038362:Glycogen Synthase Kinase 3; D000071679:Glycogen... | Histopathology | 2,013 | D014408:Biomarkers, Tumor; C495247:WNT1 protein, human; D051155:Wnt1 Protein; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3 |
Physiologic affects of altitude on recreational climbers. | OBJECTIVES
Previous analyses of physiologic parameter changes during ascent to altitude have incorporated small numbers of well-trained climbers. The effects of altitude illness are more likely to occur and may come to medical attention more frequently in unacclimatized recreational individuals. We sought to evaluate a... | 10.1016/j.ajem.2008.09.025 | 19,931,754 | D000328:Adult; D000531:Altitude; D001274:Atmospheric Pressure; D001794:Blood Pressure; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009051:Mountaineering; D010092:Oximetry; D010809:Physical Fitness; D011446:Prospective Studies; D012123:Pulmonary Vent... | The American journal of emergency medicine | 2,009 | |
SOCE and STIM1 signaling in the heart: Timing and location matter. | Store operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to striated muscle was solidified with the description of skeletal myopathies that result from mutations in ... | 10.1016/j.ceca.2018.11.008 | 30,508,734 | D000818:Animals; D002118:Calcium; D020013:Calcium Signaling; D006801:Humans; D009206:Myocardium; D032383:Myocytes, Cardiac; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; D012849:Sinoatrial Node; D000071737:Stromal Interaction Molecule 1 | Cell calcium | 2,019 | D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C103530:STIM1 protein, human; D000071737:Stromal Interaction Molecule 1; D002118:Calcium |
Implant Disease Risk Assessment IDRA-a tool for preventing peri-implant disease. | OBJECTIVE
This treatment concept paper introduces a risk assessment tool, the Implant Disease Risk Assessment, (IDRA) which estimates the risk for a patient to develop peri-implantitis.
MATERIALS AND METHODS
The functional risk assessment diagram was constructed incorporating eight parameters, each with documented ev... | 10.1111/clr.13585 | 32,003,037 | D016301:Alveolar Bone Loss; D015921:Dental Implants; D006801:Humans; D057873:Peri-Implantitis; D010518:Periodontitis; D018570:Risk Assessment; D012307:Risk Factors | Clinical oral implants research | 2,020 | D015921:Dental Implants |
Extensive genetic polymorphism of four plasma alpha-protease inhibitors in pigs and evidence for tight linkage between the structural loci of these inhibitors. | Two-dimensional horizontal gel electrophoresis of pig plasma samples (under non-denaturing conditions) using Immobiline pH gradient gels 4.0-6.0 for the first dimension separation, resulted in clear resolution of the variants of four different alpha-protease inhibitors (protease inhibitor -1 and -2, PI1 and PI2; post-a... | 10.1111/j.1365-2052.1986.tb00733.x | 3,488,698 | D000483:Alleles; D000818:Animals; D001798:Blood Proteins; D005787:Gene Frequency; D008040:Genetic Linkage; D011110:Polymorphism, Genetic; D011480:Protease Inhibitors; D013552:Swine; D000515:alpha 1-Antitrypsin | Animal genetics | 1,986 | D001798:Blood Proteins; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin |
[Thrombocytopenia-induced parenchyma hemorrhage in a newborn infant. A contribution to the etiology of so-called arachnoid cysts]. | We report on a newborn baby with thrombocytopenia who developed neonatal seizures caused by a temporal lobe hemorrhage as shown by cerebral ultrasonography. This hemorrhage was followed by a cyst isodense to intracerebral fluid. Differential diagnostic aspects concerning the etiology of arachnoideal cysts will be discu... | 2,030,700 | D016080:Arachnoid Cysts; D002543:Cerebral Hemorrhage; D004453:Echoencephalography; D005317:Fetal Growth Retardation; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D013036:Spasms, Infantile; D013702:Temporal Lobe; D013921:Thrombocytopenia | Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde | 1,991 | ||
Does hormone replacement therapy (HRT) cause breast cancer? An application of causal principles to three studies. | BACKGROUND
Based principally on findings in three studies, the Collaborative Reanalysis (CR), the Women's Health Initiative (WHI), and the Million Women Study, it is claimed that hormone replacement therapy (HRT) is an established cause of breast cancer. The authors have previously reviewed those studies (Parts 1-4). T... | 10.1136/jfprhc-2012-100508 | 23,493,592 | D001943:Breast Neoplasms; D015984:Causality; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans | The journal of family planning and reproductive health care | 2,013 | |
TPA induces subcellular translocation and subsequent down-regulation of both phorbol ester binding and protein kinase C activities in MCF-7 cells. | Phorbol ester TPA has been previously shown to induce a rapid translocation, followed by a progressive decline of protein kinase C activity in MCF-7 cells (J.M. Darbon et al, 1986, Biochem. Biophys. Res. Comm. 137: 1159-1166). We show now a parallel TPA-induced movement of phorbol ester binding sites from the cytosolic... | 10.1016/0006-291x(87)90562-6 | 3,476,116 | D000818:Animals; D001665:Binding Sites; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D002460:Cell Line; D007700:Kinetics; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters; D011493:Protein Kinase C; D011955:Receptors, Drug; D011971:Receptors, Immunologic; D013347:Subcellular Fractions; D013... | Biochemical and biophysical research communications | 1,987 | D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D010703:Phorbol Esters; D011955:Receptors, Drug; D011971:Receptors, Immunologic; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate |
Transitions to asexuality result in excess amino acid substitutions. | Theory predicts that linkage between genetic loci reduces the efficiency of purifying selection. Because of the permanent linkage of all heritable genetic material, asexual lineages may be exceptionally prone to deleterious-mutation accumulation in both nuclear and organelle genes. Here, we show that the ratio of the r... | 10.1126/science.1118152 | 16,484,491 | D019943:Amino Acid Substitution; D000818:Animals; D001499:Bayes Theorem; D003621:Daphnia; D019143:Evolution, Molecular; D005260:Female; D050259:Genes, Mitochondrial; D016013:Likelihood Functions; D008297:Male; D024101:Mitochondrial Proteins; D009154:Mutation; D010312:Parthenogenesis; D010802:Phylogeny; D011995:Recombin... | Science (New York, N.Y.) | 2,006 | D024101:Mitochondrial Proteins |
[Evaluation of efficacy, safety and stability of lasik-zyoptix as compared to lasik-planoscan in myopia patients with or without astigmatism]. | AIM
To compare the efficacy, safety and stability of laser in-situ keratomileusis (LASIK) Zyoptix and PlanoScan (PS) systems for the surgical correction of myopia with and without astigmatism.
METHODS
In this retrospective study we analyzed the results of 198 eyes of 99 patients (randomly chosen) who underwent LASIK ... | 16,599,310 | D000293:Adolescent; D000328:Adult; D001251:Astigmatism; D004867:Equipment Design; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008875:Middle Aged; D009216:Myopia; D012189:Retrospective Studies; D016896:Treatment Outcome | Harefuah | 2,006 | ||
Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type. | PURPOSE
To determine whether there are any differences in therapeutic response, patterns of systemic recurrence, and prognosis of patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type, by the cyclooxygenase-2 (COX-2) expression.
PATIENTS AND METHODS
Thirty-four patients with Ann Arbor Stage I and I... | 10.1016/j.ijrobp.2006.07.1387 | 17,049,184 | D000293:Adolescent; D000328:Adult; D000368:Aged; D051546:Cyclooxygenase 2; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D016399:Lymphoma, T-Cell; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D009669:Nose Neoplasms; D011379:Prognosis; D012008:Recurrence... | International journal of radiation oncology, biology, physics | 2,007 | D009363:Neoplasm Proteins; D051546:Cyclooxygenase 2 |
Effects of idealized joint geometry on finite element predictions of cartilage contact stresses in the hip. | Computational models may have the ability to quantify the relationship between hip morphology, cartilage mechanics and osteoarthritis. Most models have assumed the hip joint to be a perfect ball and socket joint and have neglected deformation at the bone-cartilage interface. The objective of this study was to analyze f... | 10.1016/j.jbiomech.2010.01.010 | 20,176,359 | D000818:Animals; D002356:Cartilage; D020342:Finite Element Analysis; D006621:Hip Joint; D006801:Humans; D008954:Models, Biological; D016059:Range of Motion, Articular; D013312:Stress, Physiological; D016138:Walking; D016474:Weight-Bearing | Journal of biomechanics | 2,010 | |
Characterization of endolysin from a Salmonella Typhimurium-infecting bacteriophage SPN1S. | The full genome sequence of bacteriophage SPN1S, which infects Salmonella, contains genes that encode homologues of holin, endolysin and Rz/Rz1-like accessory proteins, which are 4 phage lysis proteins. The ability of these proteins to lyse Escherichia coli cells when overexpressed was evaluated. In contrast to other e... | 10.1016/j.resmic.2012.01.002 | 22,289,622 | D000818:Animals; D001433:Bacteriolysis; D002645:Chickens; D002846:Chromatography, Affinity; D004279:DNA, Viral; D010450:Endopeptidases; D004795:Enzyme Stability; D004926:Escherichia coli; D015870:Gene Expression; D016679:Genome, Viral; D006090:Gram-Negative Bacteria; D006094:Gram-Positive Bacteria; D006863:Hydrogen-Ion... | Research in microbiology | 2,012 | D004279:DNA, Viral; D011993:Recombinant Fusion Proteins; D010450:Endopeptidases; C001143:endolysin |
Trans-fatty acid levels in erythrocytes in Europe. | PURPOSE
High, but not low levels of trans-fatty acids (TFA) in erythrocytes are associated with increased mortality. Current erythrocyte TFA levels in Europe are not known.
METHODS
TFA levels in samples submitted by physicians for erythrocyte omega-3 fatty acid analyses are reported, as analysed with a method (HS-Ome... | 10.1007/s00394-016-1218-9 | 27,151,382 | D015415:Biomarkers; D003430:Cross-Sectional Studies; D003611:Dairy Products; D004912:Erythrocytes; D005060:Europe; D015525:Fatty Acids, Omega-3; D006801:Humans; D008460:Meat; D012307:Risk Factors; D044242:Trans Fatty Acids | European journal of nutrition | 2,017 | D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D044242:Trans Fatty Acids |
PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis. | The susceptibility genes for psoriasis remain to be identified. At least one of these must be in the major histocompatibility complex (MHC) to explain associations with alleles at human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and C4. In fact, most of these alleles are components of just two ancestral haplotypes (AH... | 10.1046/j.1365-2249.2000.01140.x | 10,691,930 | D001483:Base Sequence; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011506:Proteins; D011565:Psoriasis; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D012867:Skin | Clinical and experimental immunology | 2,000 | C089801:HCG9 non-protein coding RNA, human; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen; D011506:Proteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated |
Chromaffin cell transplant in spinal cord reduces secondary allodynia induced by formalin in the rat. Role of opioid receptors and α₂-adrenoceptors. | In the present study, the effect of chromaffin cell transplant in the spinal cord was evaluated on formalin-induced mechanical secondary allodynia in the rat. Chromaffin cells were transplanted into the lumbar subarachnoid space before or after formalin injection. Subcutaneous formalin injection (50 μl, 1%) produced lo... | 10.1016/j.ejphar.2011.06.030 | 21,741,968 | D058669:Adrenergic alpha-2 Receptor Antagonists; D000818:Animals; D002470:Cell Survival; D019439:Chromaffin Cells; D005260:Female; D005557:Formaldehyde; D006930:Hyperalgesia; D009271:Naltrexone; D009292:Narcotic Antagonists; D051381:Rats; D017208:Rats, Wistar; D018341:Receptors, Adrenergic, alpha-2; D011957:Receptors, ... | European journal of pharmacology | 2,011 | D058669:Adrenergic alpha-2 Receptor Antagonists; D009292:Narcotic Antagonists; D018341:Receptors, Adrenergic, alpha-2; D011957:Receptors, Opioid; D005557:Formaldehyde; D015016:Yohimbine; D009271:Naltrexone |
Machine learning predicts individual cancer patient responses to therapeutic drugs with high accuracy. | Precision or personalized cancer medicine is a clinical approach that strives to customize therapies based upon the genomic profiles of individual patient tumors. Machine learning (ML) is a computational method particularly suited to the establishment of predictive models of drug response based on genomic profiles of t... | 10.1038/s41598-018-34753-5 | 30,401,894 | D000465:Algorithms; D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D019295:Computational Biology; D016208:Databases, Factual; D003841:Deoxycytidine; D005260:Female; D005472:Fluorouracil; D015894:Genome, Human; D006801:Humans; D000069550:Machine Learning; D009369:Neoplasms; D010051:Ovarian Neoplasms... | Scientific reports | 2,018 | D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D003841:Deoxycytidine; D005472:Fluorouracil; D000093542:Gemcitabine |
Establishment of SIAISi001-A, an induced pluripotent stem cell (iPSC) line from 66-year old mild cognitive impairment (MCI) with two copies of APOE4 gene. | A 66-year old mild cognitive impairment (MCI) female patient donated her Peripheral blood mononuclear cells (PBMC). PBMC was reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, KLF4, SOX2 and C-MYC. The pluripotency of transgene-free iPSCs was confirmed by immunocytochemistry ... | 10.1016/j.scr.2020.101702 | 32,007,762 | D000368:Aged; D053327:Apolipoprotein E4; D060825:Cognitive Dysfunction; D005260:Female; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D000090062:Kruppel-Like Factor 4 | Stem cell research | 2,020 | D053327:Apolipoprotein E4; C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4 |
[Preliminary study on gene expression profile of endometrial adenocarcinoma]. | OBJECTIVE
To determine candidate genes of endometrial adenocarcinoma.
METHODS
To compare the gene expression profile in 2 endometrial adenocarcinoma tissues and 2 normal endometria by HGEC-40s GeneChip probe including 4096 genes array. Expression differences between normal and malignant tissue groups were measured by... | 14,575,571 | D000230:Adenocarcinoma; D064127:Aurora Kinases; D018797:Cell Cycle Proteins; D016889:Endometrial Neoplasms; D005260:Female; D058851:GPI-Linked Proteins; D020869:Gene Expression Profiling; D006801:Humans; D008565:Membrane Proteins; D017346:Protein Serine-Threonine Kinases; D019009:Proto-Oncogene Proteins c-kit | Zhonghua zhong liu za zhi [Chinese journal of oncology] | 2,003 | D018797:Cell Cycle Proteins; C096192:GAS1 protein, human; D058851:GPI-Linked Proteins; D008565:Membrane Proteins; D019009:Proto-Oncogene Proteins c-kit; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases | |
Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression. | Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote t... | 10.3390/biom11111551 | 34,827,550 | D001943:Breast Neoplasms; D002465:Cell Movement; D016326:Extracellular Matrix Proteins; D006801:Humans; D006820:Hyaluronic Acid | Biomolecules | 2,021 | D016326:Extracellular Matrix Proteins; D006820:Hyaluronic Acid |
UDP-glycosyltransferases contribute to the tolerance of parasitoid wasps towards insecticides. | Meteorus pulchricornis (Wesmael) (Hymenoptera: Braconidae) is a predominant endoparasitoid of lepidopteran pests in mulberry fields. Extensive application of insecticides puts natural enemies under threat. UDP-glycosyltransferases (UGTs), as important detoxification enzymes, potentially contribute to the detoxification... | 10.1016/j.pestbp.2021.104967 | 34,802,517 | D000818:Animals; D016695:Glycosyltransferases; D007306:Insecticides; D014530:Uridine Diphosphate; D014863:Wasps | Pesticide biochemistry and physiology | 2,021 | D007306:Insecticides; D014530:Uridine Diphosphate; D016695:Glycosyltransferases |
Renal Function in Receptors With Simultaneous Liver-Kidney Transplant From the Same Donor. | Controversy surrounds the suitability of simultaneous liver-kidney transplant (SLKT) when compared with sequential transplant. Pretransplant renal failure is a post-transplant mortality predictor, and studies demonstrate worse functioning and lower survival of the renal graft when compared with kidney transplant alone ... | 10.1016/j.transproceed.2021.08.059 | 34,920,882 | D006085:Graft Survival; D006801:Humans; D007223:Infant; D007668:Kidney; D016030:Kidney Transplantation; D008099:Liver; D012189:Retrospective Studies; D016896:Treatment Outcome | Transplantation proceedings | 2,022 | |
Sleep Deficiency is a Modifiable Risk Factor for Obesity and Cognitive Impairment and Associated with Elevated Visfatin. | AIM
To study the interaction between sleep deprivation, obesity and cognitive functions, and the effect of following a balanced low caloric diet and increasing sleep duration on those variables.
SUBJECTS AND METHODS
Ninety two obese females with mean age 47.00 ± 2.00 years and body mass index (BMI) 36.14 ± 3.00 kg/m²... | 10.3889/oamjms.2015.063 | 27,275,243 | Open access Macedonian journal of medical sciences | 2,015 | ||
Histology and transcriptome insights into the early processes of intestinal anastomotic healing: a rat model. | BACKGROUND
Understanding the early processes underlying intestinal anastomotic healing is crucial to comprehend the pathophysiology of anastomotic leakage. The aim of this study was to assess normal intestinal anastomotic healing and disturbed healing in rats to investigate morphological, cellular and intrinsic molecul... | 10.1093/bjsopen/zrad099 | 37,855,751 | D051381:Rats; D006801:Humans; D000818:Animals; D057868:Anastomotic Leak; D059467:Transcriptome; D017208:Rats, Wistar; D000714:Anastomosis, Surgical; D014945:Wound Healing | BJS open | 2,023 | |
Epidemiology and genetics of Meniere's disease. | PURPOSE OF REVIEW
This review discusses the recent developments on the understanding of epidemiology and genetics of Meniere's disease.
RECENT FINDINGS
Meniere's disease has been shown to be associated with several comorbidities, such as migraine, anxiety, allergy and immune disorders. Recent studies have investigate... | 10.1097/WCO.0000000000001227 | 37,865,853 | Current opinion in neurology | 2,023 | ||
Analysis of mitochondrial respiratory function in tissue biopsies and blood cells. | PURPOSE OF REVIEW
The review provides an overview on latest methodological strategies to assess mitochondrial respiratory function in tissue biopsies or blood cells. In addition, it summarizes the recent literature related to this topic.
RECENT FINDINGS
Today, the study of mitochondrial function in key metabolic acti... | 10.1097/MCO.0000000000000486 | 29,939,971 | D000273:Adipose Tissue; D001706:Biopsy; D001773:Blood Cells; D006801:Humans; D008099:Liver; D008928:Mitochondria; D018482:Muscle, Skeletal; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption | Current opinion in clinical nutrition and metabolic care | 2,018 | |
Ascitic tumor cell cycle metabolism and energetics. | Data are presented on Ehrlich ascitic tumor cells energetic metabolism, activities of the glycolytic enzymes and the pentose phosphate pathway enzymes, contents and synthesis rates of the macromolecules at various cell cycle stages. An attempt was made to correct the direct measurement by taking into consideration a sy... | 2,041,582 | D000818:Animals; D001693:Biological Transport, Active; D002286:Carcinoma, Ehrlich Tumor; D002453:Cell Cycle; D002784:Cholesterol; D004734:Energy Metabolism; D007399:Interphase; D007939:Leukemia L1210; D007941:Leukemia P388; D008291:Malate Dehydrogenase; D008938:Mitosis; D009438:Neuraminic Acids; D009696:Nucleic Acids; ... | Neoplasma | 1,991 | D009438:Neuraminic Acids; D009696:Nucleic Acids; D002784:Cholesterol; D008291:Malate Dehydrogenase; D013936:Thymidine | |
Differentiation of ischemic and dilated cardiomyopathy on electrocardiograms. | Differentiating coronary artery disease with left ventricular dysfunction from dilated cardiomyopathy is important prognostically and therapeutically. To provide a diagnostic algorithm to distinguish these conditions using a standard 12-lead electrocardiogram, all 105 patients with left ventricular ejection fraction < ... | 10.1177/021849230801600204 | 18,381,865 | D000328:Adult; D000368:Aged; D000465:Algorithms; D009202:Cardiomyopathies; D002311:Cardiomyopathy, Dilated; D017023:Coronary Angiography; D023921:Coronary Stenosis; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System; D006801:Humans; D008297:Male; D008875:Middle... | Asian cardiovascular & thoracic annals | 2,008 | |
Use of blood pressure measurements extracted from the electronic health record in predicting Alzheimer's disease: A retrospective cohort study at two medical centers. | INTRODUCTION
Studies investigating the relationship between blood pressure (BP) measurements from electronic health records (EHRs) and Alzheimer's disease (AD) rely on summary statistics, like BP variability, and have only been validated at a single institution. We hypothesize that leveraging BP trajectories can accura... | 10.1002/alz.12676 | 35,429,343 | D006801:Humans; D057286:Electronic Health Records; D012189:Retrospective Studies; D000544:Alzheimer Disease; D001794:Blood Pressure; D018570:Risk Assessment | Alzheimer's & dementia : the journal of the Alzheimer's Association | 2,022 | |
Purification of beta-amylase from alfalfa (Medicago sativa L.) seeds. | An amylase from alfalfa (Medicago sativa L. c.v. Moapa) seeds was purified by column chromatography and gel filtration, followed by chromatofocusing on Mono P HR 5/20. The last step was effective for separation of the alfalfa amylase to a homogeneous state. The purified amylase was identified as beta-amylase from the f... | 10.1093/oxfordjournals.jbchem.a122644 | 2,470,731 | D000681:Amylases; D002241:Carbohydrates; D004591:Electrophoresis, Polyacrylamide Gel; D007525:Isoelectric Focusing; D000455:Medicago sativa; D008970:Molecular Weight; D009904:Optical Rotation; D012639:Seeds; D001614:beta-Amylase | Journal of biochemistry | 1,989 | D002241:Carbohydrates; D000681:Amylases; D001614:beta-Amylase |
Molecular phylogeny of the Southeast Asian freshwater fish family Botiidae (Teleostei: Cobitoidea) and the origin of polyploidy in their evolution. | The freshwater fish family Botiidae is represented by seven genera on the Indian subcontinent and in East and Southeast Asia and includes diploid as well as evolutionary tetraploid species. We present a phylogeny of Botiidae including 33 species representing all described genera using the mitochondrial cytochrome b and... | 10.1016/j.ympev.2005.09.018 | 16,337,410 | D000818:Animals; D001210:Asia, Southeastern; D001499:Bayes Theorem; D003531:Cypriniformes; D045304:Cytochromes c; D004272:DNA, Mitochondrial; D019143:Evolution, Molecular; D014644:Genetic Variation; D005843:Geography; D008969:Molecular Sequence Data; D010802:Phylogeny; D012335:RNA, Ribosomal; D017422:Sequence Analysis,... | Molecular phylogenetics and evolution | 2,006 | D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal; C075526:RNA, ribosomal, 12S; D045304:Cytochromes c |
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