title large_stringlengths 0 979 | abstract large_stringlengths 1 94.7k | doi large_stringlengths 0 71 | pmid int64 21 38.1M | mesh_terms large_stringlengths 0 1.47k | journal large_stringlengths 1 239 | pubdate int16 1.97k 2.02k | chemical_list large_stringlengths 0 1.47k |
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Integrated waveguide Fabry-Perot microcavities with silicon/air Bragg mirrors. | We demonstrate in-plane microfabricated Fabry-Perot cavities with cryogenically etched silicon/air distributed Bragg reflector (DBR) mirrors and integrated silicon-on-insulator rib waveguides. Several DBR configurations and cavity lengths were measured. Various devices exhibit Q=26963, FWHM=0.060 nm, finesse F=489, fre... | 10.1364/ol.32.000533 | 17,392,912 | Optics letters | 2,007 | ||
Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives. | The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue in the field of behavioral neuroscience, where, in spite of efforts to standardize testing and assay protocols, several known and unknown sources of confounding environmental factors add to ... | 10.3389/fnbeh.2021.735387 | 34,630,052 | Frontiers in behavioral neuroscience | 2,021 | ||
Angiotensin II binding sites on isolated rat renal brush border membranes. | There is evidence that angiotensin II has a direct effect on reabsorptive processes of the kidney that are mediated by angiotensin II receptors on the proximal tubules. These receptors have not previously been localized to luminal brush border or basolateral membranes. The present study is the first to characterize the... | 10.1210/endo-111-6-1830 | 6,814,893 | D000804:Angiotensin II; D000818:Animals; D001665:Binding Sites; D004229:Dithiothreitol; D004492:Edetic Acid; D007672:Kidney Cortex; D008274:Magnesium; D015636:Magnesium Chloride; D008854:Microscopy, Electron; D008871:Microvilli; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride | Endocrinology | 1,982 | D015636:Magnesium Chloride; D000804:Angiotensin II; D012965:Sodium Chloride; D004492:Edetic Acid; D008274:Magnesium; D004229:Dithiothreitol |
[Differential diagnosis and therapy of hypoglycemia in childhood]. | Occurrence of hypoglycaemia is directly connected to fuel balance. Compared to free fatty acids, glucose is rapidly exhausted. Therefore, besides disturbances in available glucose (i.e. defects in gluconeogenesis or glycogenolysis) as well as their hormonal control, defects of beta-oxidation might be possible causes. A... | 8,411,844 | D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004734:Energy Metabolism; D006801:Humans; D006946:Hyperinsulinism; D007003:Hypoglycemia; D007223:Infant; D007231:Infant, Newborn | Kinderarztliche Praxis | 1,993 | ||
The non-invasive monitoring of low dose, infusional 5-fluorouracil and its modulation by interferon-alpha using in vivo 19F magnetic resonance spectroscopy in patients with colorectal cancer: a pilot study. | BACKGROUND
5-Fluorouracil (5-FU) is the most widely used cytotoxic drug in oncology and the only one useful in the management of colorectal cancer - a leading cause of cancer death worldwide. Recent studies of 5-FU have focused on increasing efficacy and reducing toxicity by varying the delivery schedule and combining ... | 10.1093/oxfordjournals.annonc.a058595 | 8,363,990 | D000971:Antineoplastic Combined Chemotherapy Protocols; D015179:Colorectal Neoplasms; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D005462:Fluorine Radioisotopes; D005472:Fluorouracil; D006801:Humans; D016898:Interferon-alpha; D008113:Liver Neoplasms; D009682:Magnetic Resonance Spectroscopy; D010865:P... | Annals of oncology : official journal of the European Society for Medical Oncology | 1,993 | D005462:Fluorine Radioisotopes; D016898:Interferon-alpha; D005472:Fluorouracil |
Ti plasmid and chromosomal ornithine catabolism genes of Agrobacterium tumefaciens C58. | The pTiC58 plasmid noc genes of Agrobacterium tumefaciens C58 code for nopaline oxidase (nocC), nopaline permease (nocP), the inducible periplasmic protein n1 (nocB), and a function(s) required for ornithine catabolism (nocA). In addition, strains C58 and Ach-5 of A. tumefaciens have chromosomal ornithine catabolism ge... | 10.1128/jb.155.1.196-202.1983 | 6,305,908 | D001426:Bacterial Proteins; D002876:Chromosomes, Bacterial; D005796:Genes; D005798:Genes, Bacterial; D007700:Kinetics; D026901:Membrane Transport Proteins; D009154:Mutation; D009952:Ornithine; D000587:Oxidoreductases Acting on CH-NH Group Donors; D010641:Phenotype; D010957:Plasmids; D012231:Rhizobium; D013045:Species S... | Journal of bacteriology | 1,983 | D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; C093725:NocP protein, Agrobacterium tumefaciens; D009952:Ornithine; D000587:Oxidoreductases Acting on CH-NH Group Donors; C021882:nopaline dehydrogenase |
Current trends in restorative proctocolectomy: introduction of an ultrasonically activated scalpel. | PURPOSE
We evaluated the usefulness of an ultrasonically activated scalpel (Harmonic Scalpel) for mucosal proctocolectomy and ileal J-pouch-anal anastomosis.
METHODS
Seventy-four patients with ulcerative colitis (70 patients) and familial adenomatous polyposis (4 patients) underwent mucosectomy using the Harmonic Sca... | 10.1007/BF02234229 | 10,528,778 | D000328:Adult; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa; D008297:Male; D016737:Proctocolectomy, Restorative; D013525:Surgical Instruments; D014465:Ultrasonics | Diseases of the colon and rectum | 1,999 | |
Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12. | The purpose of this study was to assess 65 pedigrees ascertained through a Bipolar I (BPI) proband for evidence of linkage, using nonparametric methods in a genome-wide scan and for possible parent of origin effect using several analytical methods. We identified 15 loci with nominally significant evidence for increased... | 10.1038/sj.mp.4001277 | 12,660,801 | D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder; D002877:Chromosomes, Human; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D002889:Chromosomes, Human, Pair 2; D002894:Chromosomes, Human, Pair 4; D002898:Chromosomes, Human, Pair 8; D005192:Family Health; D008040:Genetic Linkage; D... | Molecular psychiatry | 2,003 | |
Cytotoxic alkyl benzoquinones and alkyl phenols from Ardisia virens. | Bioassay-guided fractionation of roots and stems of Ardisia virens Kurz (Myrsinaceae) led to isolation of fourteen compounds, (2'R)-6-(2'-acetoxypentadecyl)-5-hydroxy-2-methoxy-1,4-benzoquinone (1), (2'R)-6-(2'-acetoxytridecyl)-5-hydroxy-2-methoxy-1,4-benzoquinone (2), (2'R)-6-(2'-acetoxytridecyl)-2-methoxy-1,4-dihydro... | 10.1016/j.phytochem.2009.09.006 | 19,833,361 | D000473:Alkanes; D000478:Alkylation; D000972:Antineoplastic Agents, Phytogenic; D031644:Ardisia; D016227:Benzoquinones; D045744:Cell Line, Tumor; D006536:Heptanes; D006801:Humans; D020128:Inhibitory Concentration 50; D009369:Neoplasms; D010636:Phenols; D008517:Phytotherapy; D010936:Plant Extracts; D018517:Plant Roots; ... | Phytochemistry | 2,009 | C548526:1-(3,5-dihydroxyphenyl)heptan-1-one; C548527:1-(3,5-dihydroxyphenyl)pentadecan-1-one; D000473:Alkanes; D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D006536:Heptanes; D010636:Phenols; D010936:Plant Extracts |
Genetic test and periodontal disease. | Periodontitis initiated by specific bacteria that activate host mechanisms destroying bone and connective tissues that support the teeth. It has a relative high prevalence in the population, representing the greatest cause of tooth loss. Like any other inflammatory condition, periodontal diseases might pose additional ... | 20,608,033 | D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D010510:Periodontal Diseases; D015995:Prevalence | Likars'ka sprava | 2,010 | ||
Utility of the von Willebrand factor collagen binding assay in the diagnosis of von Willebrand disease. | von Willebrand Disease (VWD) is the most common inherited bleeding disorder and also arises as an acquired defect (AVWS). VWD and AVWS are due to quantitative deficiencies and/or qualitative defects in von Willebrand factor (VWF), an adhesive plasma protein with multiple activities. Diagnosis of VWD is problematic, bei... | 10.1002/ajh.24556 | 27,622,788 | D019411:Clinical Laboratory Techniques; D003094:Collagen; D006801:Humans; D011485:Protein Binding; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014842:von Willebrand Diseases; D014841:von Willebrand Factor | American journal of hematology | 2,017 | D014841:von Willebrand Factor; D003094:Collagen |
The Effect of Increasing Interphase Gap on N1 Latency of the Electrically Evoked Compound Action Potential and the Stimulation Level Offset in Human Cochlear Implant Users. | OBJECTIVE
This study reports two potential biomarkers of the physiological status of the cochlear nerve (CN) in cochlear implant users.
DESIGN
This project represents a complementary analysis on a subset of electrophysiological data from our recently published study. This study compared changes in N1 latency and stim... | 10.1097/AUD.0000000000000919 | 32,701,729 | D000200:Action Potentials; D002648:Child; D019929:Cochlear Implantation; D003054:Cochlear Implants; D003056:Cochlear Nerve; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory; D006801:Humans; D007399:Interphase | Ear and hearing | 2,021 | |
The role of a conserved threonine residue in the leader peptide of lasso peptide precursors. | The conserved threonine (Thr) residue in the penultimate position of the leader peptide of lasso peptides microcin J25 and capistruin can be effectively replaced by several amino acids close in size and shape to Thr. These findings suggest a model for lasso peptide biosynthesis in which the Thr sidechain is a recogniti... | 10.1039/c2cc17211a | 22,222,556 | D000595:Amino Acid Sequence; D001430:Bacteriocins; D017124:Conserved Sequence; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides; D011487:Protein Conformation; D011498:Protein Precursors; D013912:Threonine | Chemical communications (Cambridge, England) | 2,012 | D001430:Bacteriocins; D010455:Peptides; D011498:Protein Precursors; C533129:capistruin; C020411:microcin; D013912:Threonine |
Composition analysis and antioxidant activities of the Rhus typhina L. stem. | The present investigation reports the chemical composition of the Rhus typhina L. stem identified via mass spectrometry and NMR as gallic acid, 1-O-galloyl-β-D-glucose, tryptophan, scopolin, methyl gallate, fustin, quercetin, rutin, and 1,2,3,4,6-penta-O-galloyl-β-D-glucose. The antioxidant properties and the chemical ... | 10.1016/j.jpha.2019.01.002 | 31,929,942 | Journal of pharmaceutical analysis | 2,019 | ||
Early administration of tirofiban after urokinase-mediated intravenous thrombolysis reduces early neurological deterioration in patients with branch atheromatous disease. | OBJECTIVES
To investigate the effects of early administration of tirofiban after intravenous thrombolysis on early neurological deterioration in patients with branch atheromatous disease.
METHODS
We analyzed clinical data from patients with branch atheromatous disease. We enrolled seven cases into the urokinase-only ... | 10.1177/0300060520926298 | 32,459,110 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D000083242:Ischemic Stroke; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosc... | The Journal of international medical research | 2,020 | D014568:Urokinase-Type Plasminogen Activator; D000077466:Tirofiban |
Boosting chiral amplification in plasmon-coupled circular dichroism using discrete silver nanorods as amplifiers. | Remarkable chiral amplification in plasmon-coupled circular dichroism spectroscopy (CD) is demonstrated by using discrete Ag nanorods as amplifiers. An unprecedented CD enhancement factor of over 3000 times is achieved without resonant or near-resonant exciton-plasmon couplings. | 10.1039/d1cc01891d | 34,223,840 | Chemical communications (Cambridge, England) | 2,021 | ||
SOCS3 deficiency promotes M1 macrophage polarization and inflammation. | Macrophages participate in both the amplification of inflammation at the time of injury and downregulation of the inflammatory response to avoid excess tissue damage. These divergent functions of macrophages are dictated by their microenvironment, especially cytokines, which promote a spectrum of macrophage phenotypes.... | 10.4049/jimmunol.1201168 | 22,925,925 | D000818:Animals; D001854:Bone Marrow Cells; D016764:Cell Polarity; D016130:Immunophenotyping; D007249:Inflammation; D018836:Inflammation Mediators; D008262:Macrophage Activation; D008264:Macrophages; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D015398:Signal Transduction;... | Journal of immunology (Baltimore, Md. : 1950) | 2,012 | D018836:Inflammation Mediators; C106644:SOCS3 protein, human; C491411:Socs3 protein, mouse; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins |
Carbon-coated LiTi(2)(PO(4))(3) : an ideal insertion host for lithium-ion and sodium-ion batteries. | We report the extraordinary performance of carbon-coated sodium super ion conductor (NASICON)-type LiTi2 (PO4 )3 as an ideal host matrix for reversible insertion of both Li and Na ions. The NASICON-type compound was prepared by means of a Pechini-type polymerizable complex method and was subsequently carbon coated. Sev... | 10.1002/asia.201301461 | 24,449,337 | Chemistry, an Asian journal | 2,014 | ||
A National Survey of Transplant Surgeons and Nephrologists on Implementing Apolipoprotein L1 (APOL1) Genetic Testing Into Clinical Practice. | INTRODUCTION
There is debate over whether Apolipoprotein L1 (APOL1) gene risk variants contribute to African American (AA) live donors' (LD) increased risk of kidney failure. Little is known about factors influencing physicians' integration of APOL1 genetic testing of AA LDs into donor evaluation.
DESIGN
We conducted... | 10.1177/1526924818817048 | 30,541,404 | D000328:Adult; D001741:Black or African American; D000368:Aged; D000075944:Apolipoprotein L1; D003430:Cross-Sectional Studies; D005260:Female; D005820:Genetic Testing; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D000072104:Nephrologists; D010818:Practice Pat... | Progress in transplantation (Aliso Viejo, Calif.) | 2,019 | C108666:APOL1 protein, human; D000075944:Apolipoprotein L1 |
Effects of repeated Strongylus vulgaris inoculations and concurrent ivermectin treatments on mesenteric arterial lesions in pony foals. | Eight of 10 pony foals reared under helminth-free conditions were inoculated PO with 50 Strongylus vulgaris infective larvae/week for 4 weeks, at which time 1 foal died of acute verminous arteritis. Inoculation of 7 remaining foals continued at 2-week intervals for 20 weeks. Of the 7 foals, 3 were treated with ivermect... | 2,327,628 | D000284:Administration, Oral; D000818:Animals; D005260:Female; D006734:Horse Diseases; D006736:Horses; D007559:Ivermectin; D008297:Male; D008638:Mesenteric Arteries; D009349:Nematode Infections; D013323:Strongylus; D014652:Vascular Diseases | American journal of veterinary research | 1,990 | D007559:Ivermectin | |
Warming and acidification threaten glass sponge Aphrocallistes vastus pumping and reef formation. | The glass sponge Aphrocallistes vastus contributes to the formation of large reefs unique to the Northeast Pacific Ocean. These habitats have tremendous filtration capacity that facilitates flow of carbon between trophic levels. Their sensitivity and resilience to climate change, and thus persistence in the Anthropocen... | 10.1038/s41598-020-65220-9 | 32,424,237 | D000818:Animals; D057231:Climate Change; D057894:Coral Reefs; D017753:Ecosystem; D057232:Global Warming; D006863:Hydrogen-Ion Concentration; D053580:Muscle Strength; D018482:Muscle, Skeletal; D010140:Pacific Ocean; D011161:Porifera; D012623:Seawater | Scientific reports | 2,020 | |
Comparison of Amplix® hepatitis B virus and Roche COBAS AmpliPrep/COBAS Taqman hepatitis B virus assay in quantifying HBV DNA in plasma of chronic hepatitis B in Senegal. | INTRODUCTION
quantification of hepatitis B virus DNA, a key element in the management of chronic hepatitis B, allows a more direct and reliable measurement of viral replication and monitoring of the virological response to therapy. Polymerase chain reaction (PCR) platforms performing this quantification and adaptable t... | 10.11604/pamj.2021.38.294.24819 | 34,178,213 | D004279:DNA, Viral; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic; D006801:Humans; D021141:Nucleic Acid Amplification Techniques; D060888:Real-Time Polymerase Chain Reaction; D015203:Reproducibility of Results; D012675:Senegal; D019562:Viral Load | The Pan African medical journal | 2,021 | D004279:DNA, Viral |
[Pleurodesis in malignant pleural effusion: bleomycin vs. mitoxantrone]. | In a controlled clinical trial we investigated 102 patients with malignant pleural effusion due to breast cancer, lung cancer, ovarian cancer and other tumors to compare the therapeutic effect and adverse events of pleurodesis with bleomycin (BMC) or mitoxantrone (MIT) via chest tube. Finally 96 patients had been treat... | 9,221,383 | D000368:Aged; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D001761:Bleomycin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone; D016066:Pleural Effusion, Malignant; D018700:Pleurodesis; D011446:Prospective Studies; D016896:Treatment Outcome | Pneumologie (Stuttgart, Germany) | 1,997 | D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D001761:Bleomycin; D008942:Mitoxantrone | |
An analysis of teacher preparation in deaf education: programs approved by the Council on Education of the Deaf. | An analysis of the most recent self-study reports of the 46 teacher preparation programs approved by the Council on Education of the Deaf yielded data on program demographics, curriculum and content, faculty, practicum, students, and graduates. Only 4 of the 46 teacher preparation programs had been established since 19... | 10.1353/aad.2012.0246 | 12,833,820 | D003638:Deafness; D004500:Education, Graduate; D004519:Education, Special; D006801:Humans; D015397:Program Evaluation; D013663:Teaching | American annals of the deaf | 2,002 | |
Modeling the seasonal adaptation of circadian clocks by changes in the network structure of the suprachiasmatic nucleus. | The dynamics of circadian rhythms needs to be adapted to day length changes between summer and winter. It has been observed experimentally, however, that the dynamics of individual neurons of the suprachiasmatic nucleus (SCN) does not change as the seasons change. Rather, the seasonal adaptation of the circadian clock ... | 10.1371/journal.pcbi.1002697 | 23,028,293 | D000222:Adaptation, Physiological; D001683:Biological Clocks; D057906:Circadian Clocks; D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net; D009473:Neuronal Plasticity; D009991:Oscillometry; D012621:Seasons; D013493:Suprachiasmatic Nucleus | PLoS computational biology | 2,012 | |
Addressing Antimicrobial Resistance through New Medicinal and Synthetic Chemistry Strategies. | Over the past century, a multitude of derivatives of structural scaffolds with established antimicrobial potential have been prepared and tested, and a variety of new scaffolds have emerged. The effectiveness of antibiotics, however, is in sharp decline because of the emergence of drug-resistant microorganisms. The pre... | 10.1177/2472555218812657 | 30,523,713 | D000900:Anti-Bacterial Agents; D002626:Chemistry, Pharmaceutical; D004352:Drug Resistance, Microbial; D006801:Humans; D017382:Reactive Oxygen Species; D013329:Structure-Activity Relationship | SLAS discovery : advancing life sciences R & D | 2,019 | D000900:Anti-Bacterial Agents; D017382:Reactive Oxygen Species |
Increased COVID-19 Mortality in People With Previous Cerebrovascular Disease: A Population-Based Cohort Study. | BACKGROUND
The aim of the study was to determine the association between previous stroke and mortality after coronavirus disease 2019 (COVID-19) according to sex, age groups, and stroke subtypes.
METHODS
Prospective population-based cohort study including all COVID-19 positive cases between February 1 and July 31, 20... | 10.1161/STROKEAHA.121.036257 | 34,781,706 | D000369:Aged, 80 and over; D000086382:COVID-19; D000086663:COVID-19 Vaccines; D002561:Cerebrovascular Disorders; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke | Stroke | 2,022 | D000086663:COVID-19 Vaccines |
Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK1/2 responses to gonadotropin-releasing hormone receptor activation. | The duration as well as the magnitude of mitogen-activated protein kinase activation has been proposed to regulate gene expression and other specific intracellular responses in individual cell types. Activation of ERK1/2 by the hypothalamic neuropeptide gonadotropin-releasing hormone (GnRH) is relatively sustained in a... | 10.1074/jbc.M212932200 | 12,642,580 | D000818:Animals; D001692:Biological Transport; D002460:Cell Line; D002461:Cell Line, Transformed; D002467:Cell Nucleus; D004789:Enzyme Activation; D066246:ErbB Receptors; D015870:Gene Expression; D016762:Genes, fos; D007987:Gonadotropin-Releasing Hormone; D007031:Hypothalamus; D015151:Immunoblotting; D007150:Immunohist... | The Journal of biological chemistry | 2,003 | D007295:Inositol Phosphates; D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D066246:ErbB Receptors; D019061:src-Family Kinases; D038744:Ribosomal Protein S6 Kinases, 90-kDa; C512964:Rps6ka1 protein, mouse; D011493:Protein Kinase C; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated ... |
Undermethylation at the 5' end of the albumin gene is necessary but not sufficient for albumin production by rat hepatoma cells in culture. | We have measured methylation of the albumin gene in clones of rat hepatoma cells that vary quantitatively in their rates of synthesis of albumin and in variant and hybrid cells that produce no albumin. Although the albumin gene is undermethylated for its entire length in rat liver, only the 5' end is ever undermethylat... | 10.1016/0092-8674(82)90287-2 | 7,139,715 | D000418:Albumins; D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D002874:Chromosome Mapping; D005786:Gene Expression Regulation; D005796:Genes; D006822:Hybrid Cells; D008099:Liver; D008114:Liver Neoplasms, Experimental; D008745:Methylation; D009876:Operon; D051381:Rats | Cell | 1,982 | D000418:Albumins |
Insights into mechanisms responsible for mesangial alterations associated with fibrogenic glomerulopathic light chains. | Our previous studies have shown that human mesangial cells (HMCs) incubated with fibrogenic glomerulopathic monoclonal light chains (G-LCs) obtained from the urine of patients with light chain deposition disease produce increased extracellular matrix (ECM) when compared with HMCs not exposed to fibrogenic LCs. This ove... | 10.1159/000071288 | 12,845,220 | D000911:Antibodies, Monoclonal; D020126:Brefeldin A; D002455:Cell Division; D002478:Cells, Cultured; D005353:Fibronectins; D005920:Glomerular Mesangium; D006801:Humans; D007147:Immunoglobulin Light Chains; D007678:Kidney Glomerulus; D007684:Kidney Tubules; D020574:Proto-Oncogene Proteins c-sis; D016212:Transforming Gro... | Nephron. Physiology | 2,003 | D000911:Antibodies, Monoclonal; D005353:Fibronectins; D007147:Immunoglobulin Light Chains; D020574:Proto-Oncogene Proteins c-sis; D016212:Transforming Growth Factor beta; D014415:Tunicamycin; D020126:Brefeldin A |
Immunofluorescent studies of skin in primary fibrositis syndrome. | Primary fibrositis syndrome is a painful musculoskeletal disorder of unknown cause. Although numerous hypotheses have been proposed to explain its clinical features, few studies have demonstrated a reproducible tissue abnormality in this condition. Recently, five reports of cutaneous immunoreactant deposition in primar... | 10.1016/0002-9343(86)90873-9 | 3,532,783 | D004817:Epidermis; D005356:Fibromyalgia; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G; D012867:Skin | The American journal of medicine | 1,986 | D007074:Immunoglobulin G |
[Scintigraphy with gallium-67 citrate in patients with AIDS: pathologic extrapulmonary uptake]. | 67Gallium citrate can accumulate in different inflammatory and neoplastic lesions. The mechanisms of 67Gallium uptake in abnormal tissue are still partially unknown and the tracer is considered a nonspecific indicator of disease. In AIDS patients, 67Gallium citrate is used in the diagnosis and characterization of oppor... | 8,008,901 | D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D008171:Lung Diseases; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies | La Radiologia medica | 1,994 | D002951:Citrates; D005710:Gallium Radioisotopes; D019343:Citric Acid | |
Harlequin fetus: three-dimensional sonographic findings and new diagnostic approach. | Congenital ichthyosis, otherwise known as harlequin fetus, is a severe, generally lethal, anomaly. Prenatal diagnosis is usually possible in families at risk but requires invasive fetoscopy for skin biopsy. The application of three-dimensional ultrasound enables a greatly improved analysis of the facial morphology and ... | 10.1046/j.1469-0705.2002.00708.x | 12,100,425 | D000328:Adult; D001706:Biopsy; D005260:Female; D005315:Fetal Diseases; D005332:Fetoscopy; D006801:Humans; D017490:Ichthyosis, Lamellar; D021621:Imaging, Three-Dimensional; D011247:Pregnancy; D012867:Skin; D016216:Ultrasonography, Prenatal | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology | 2,002 | |
Sleep disordered breathing in patients with chronic obstructive pulmonary disease. | Sleep has effects on breathing, including changes in respiratory control, airways resistance and muscular contractility. These sleep-related modifications in the respiratory system do not induce adverse effects in healthy subjects, but may cause problems in patients with chronic obstructive pulmonary disease (COPD). Hy... | 15,334,044 | D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive; D011659:Pulmonary Gas Exchange; D012891:Sleep Apnea Syndromes; D012895:Sleep, REM | Minerva medica | 2,004 | ||
Production of a fungistatic substance by Pseudallescheria boydii isolated from soil amended with vegetable tissues and its significance. | Four fungal isolates that were able to use vegetable tissues for multiplication in soil were isolated and identified as Pseudallescheria boydii based on morphological characteristics and ITS sequence similarity. When grown in broth prepared from the same vegetable tissues used in soil amendment, all these isolates of P... | 10.1007/s11046-009-9237-1 | 19,760,090 | D000528:Alternaria; D000935:Antifungal Agents; D003470:Culture Media; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D004355:Drug Stability; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D050296:Microbial Viability; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010935:Plant Diseases; D... | Mycopathologia | 2,010 | D000935:Antifungal Agents; D003470:Culture Media; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer |
Myeloperoxidase in chronic kidney disease. | Numerous lines of evidence implicate a role of myeloperoxidase (MPO) in the pathogenesis of cardiovascular disease (CVD). It is a well accepted fact that patients with chronic kidney disease (CKD) are at an increased risk for CVD. MPO is a pro-oxidant enzyme which could be involved in the increased susceptibility of th... | 10.1007/s12291-010-0075-1 | 22,211,010 | Indian journal of clinical biochemistry : IJCB | 2,011 | ||
Evaluation of EGFR mutation status in cytology specimens: an institutional experience. | Epidermal growth factor receptor (EGFR) mutation status has been shown to predict response to anti-EGFR tyrosine kinase inhibitors in non-small cell lung cancer (NSCLC). In patients with advanced-stage NSCLC, evaluation of mutational status is increasingly requested on biopsy or fine-needle aspiration specimens, which ... | 10.1002/dc.21851 | 22,102,479 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D002289:Carcinoma, Non-Small-Cell Lung; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D066246:ErbB Receptors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D059645:Mutation Rate; D012189... | Diagnostic cytopathology | 2,013 | D004273:DNA, Neoplasm; C512478:EGFR protein, human; D066246:ErbB Receptors |
Near-infrared fluorescent labeled peptosome for application to cancer imaging. | Nonionic amphiphilic copolypeptides, which were composed of hydrophilic poly(sarcosine) and hydrophobic poly(gamma-methyl L-glutamate) blocks, were synthesized with varying chain lengths of the blocks. The polypeptides having a suitable hydrophilic and hydrophobic balance were found to form vesicular assemblies of 100 ... | 10.1021/bc7001665 | 18,163,535 | D000818:Animals; D002942:Circular Dichroism; D004337:Drug Carriers; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D007259:Infrared Rays; D008297:Male; D051379:Mice; D008823:Micelles; D049329:Nanostructures; D009369:Neoplasms; D010455:Peptides; D010539:Permeability; D011099:Polyglutamic Acid; D051381:R... | Bioconjugate chemistry | 2,008 | D004337:Drug Carriers; D005456:Fluorescent Dyes; D008823:Micelles; D010455:Peptides; C030315:poly-gamma-methylglutamate; D011099:Polyglutamic Acid; C015475:polysarcosine; D016650:Fluorescein-5-isothiocyanate; D012521:Sarcosine |
Massive pulmonary calcification in two infants with congenital cardiac lesions. | Two infants with congenital heart disease and radiographically demonstrated pulmonary calcification are described. One infant also suffered from idiopathic hypercalcaemia and subcutaneous fat necrosis. Diffuse radiographic pulmonary calcification in infants has not been reported previously. The possible aetiology is di... | 10.1016/s0009-9260(83)80218-9 | 6,872,441 | D002114:Calcinosis; D006330:Heart Defects, Congenital; D006801:Humans; D007223:Infant; D008168:Lung; D008171:Lung Diseases; D008297:Male; D011859:Radiography | Clinical radiology | 1,983 | |
[Effect of Coflex interspinous stabilization and vertebral arch pedicle screw implantation on the stability of three-dimensional motions of the lumbar spine]. | OBJECTIVE
To evaluate the effect of Coflex interspinous stabilization and vertebral arch pedicle screw implant on the stability and motion of the lumbar spine.
METHODS
The range of motion (ROM) of 6 fresh adult human cadaver lumbar spine specimens (L(1) approximately S(1)) was biomechanically tested in forward flexio... | 20,423,867 | D000328:Adult; D001696:Biomechanical Phenomena; D002102:Cadaver; D006801:Humans; D016268:Internal Fixators; D008159:Lumbar Vertebrae; D008875:Middle Aged; D009984:Orthopedic Fixation Devices; D016059:Range of Motion, Articular; D013123:Spinal Fusion | Nan fang yi ke da xue xue bao = Journal of Southern Medical University | 2,010 | ||
Practical and quality-control aspects of multi-element analysis with quadrupole ICP-MS with special attention to urine and whole blood. | Two screening methods were developed for rapid analysis of a great number of urine and blood samples within the framework of an exposure check of the population after a firework explosion. A total of 56 elements was measured including major elements. Sample preparation consisted of simple dilution. Extensive quality co... | 10.1007/s00216-004-2654-6 | 15,221,184 | D002138:Calibration; D004781:Environmental Exposure; D006801:Humans; D007554:Isotopes; D013058:Mass Spectrometry; D011786:Quality Control; D012015:Reference Standards; D012680:Sensitivity and Specificity; D014131:Trace Elements | Analytical and bioanalytical chemistry | 2,004 | D007554:Isotopes; D014131:Trace Elements |
Multiplexed measurement of candidate blood protein biomarkers of heart failure. | AIMS
There is a critical need for better biomarkers so that heart failure can be diagnosed at an earlier stage and with greater accuracy. The purpose of this study was to design a robust mass spectrometry (MS)-based assay for the simultaneous measurement of a panel of 35 candidate protein biomarkers of heart failure, i... | 10.1002/ehf2.13320 | 33,779,078 | D015415:Biomarkers; D001798:Blood Proteins; D006333:Heart Failure; D006801:Humans; D020097:Natriuretic Peptide, Brain; D013318:Stroke Volume | ESC heart failure | 2,021 | D015415:Biomarkers; D001798:Blood Proteins; D020097:Natriuretic Peptide, Brain |
Clinical characteristics of radiation-induced optic neuropathy: A single-center retrospective study. | Purpose
To observe the clinical and imaging characteristics of radiation-induced optic neuropathy (RION).
Methods
We retrospectively reviewed the clinical data of 43 patients (69 eyes) who were diagnosed with RION at the Chinese PLA General Hospital from 2010 to 2021.
Results
The latency from radiotherapy to onset ... | 10.1016/j.aopr.2023.05.003 | 37,846,361 | Advances in ophthalmology practice and research | 2,023 | ||
Effect of fiber post length and abutment height on fracture resistance of endodontically treated premolars prepared for zirconia crowns. | The purpose of this study was to compare the fracture resistance, mode of fracture, and stress distribution of endodontically treated teeth prepared with three different fiber post lengths and two different abutment heights, using both experimental and finite element (FE) approaches. Forty-eight human maxillary premola... | 10.1007/s10266-017-0320-7 | 29,243,185 | D001641:Bicuspid; D003442:Crowns; D000044:Dental Abutments; D003764:Dental Materials; D019232:Dental Restoration Failure; D003799:Dental Stress Analysis; D020342:Finite Element Analysis; D006801:Humans; D066298:In Vitro Techniques; D011176:Post and Core Technique; D011897:Random Allocation; D019279:Resin Cements; D0195... | Odontology | 2,018 | D003764:Dental Materials; C528569:Rely-X; D019279:Resin Cements; D015040:Zirconium; C028541:zirconium oxide |
Tokyo Metropolitan Institute of Gerontology - past 22 years and its future. | The Tokyo Metropolitan Gerontology Center (TMGC) established the Tokyo Metropolitan Institute of Gerontology (TMIG) in 1972. The Institute, located adjacent to the Tokyo Metropolitan Geriatric Hospital (TMGH) and close to several other nursing facilities of TMGC, aims to promote research on aging. TMIG, originally a pa... | 10.1016/0167-4943(94)90040-x | 15,374,285 | Archives of gerontology and geriatrics | 1,994 | ||
Papillary carcinoma of the thyroid: low expression of NCAM (CD56) is associated with downregulation of VEGF-D production by tumour cells. | The expression of NCAM was investigated in tissue sections of 61 cases of papillary carcinoma and in 14 lymph node metastases using immunohistochemistry. Tumour cells of 18 primary tumours were not stained, whereas in the remaining 43 cases, NCAM was expressed in less than 5% tumour cells. Similar results were obtained... | 10.1002/path.2183 | 17,573,672 | D000328:Adult; D019002:CD56 Antigen; D002291:Carcinoma, Papillary; D002448:Cell Adhesion; D015536:Down-Regulation; D020868:Gene Silencing; D006801:Humans; D007124:Immunoenzyme Techniques; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Protei... | The Journal of pathology | 2,007 | D019002:CD56 Antigen; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D |
Isolation of Live Premature Senescent Cells Using FUCCI Technology. | Cellular senescence plays an important role in diverse biological processes such as tumorigenesis and organismal aging. However, lack of methods to specifically identify and isolate live senescent cells hampers the precise understanding of the molecular mechanisms regulating cellular senescence. Here, we report that ut... | 10.1038/srep30705 | 27,503,759 | D059447:Cell Cycle Checkpoints; D002469:Cell Separation; D016922:Cellular Senescence; D004249:DNA Damage; D004317:Doxorubicin; D005347:Fibroblasts; D006801:Humans | Scientific reports | 2,016 | D004317:Doxorubicin |
Activation tagging of the two closely linked genes LEP and VAS independently affects vascular cell number. | The complex dominant Arabidopsis thaliana mutant lettuce (let) shows the conversion of the leaf petiole into a leaf blade caused by an ectopic leaf blade formation. This is the result of the activation tagging of the LEAFY PETIOLE (LEP) gene encoding an AP2/EREBP-like transcription factor. Here, we report that in addit... | 10.1046/j.1365-313x.2002.01470.x | 12,472,696 | D000595:Amino Acid Sequence; D017360:Arabidopsis; D029681:Arabidopsis Proteins; D001483:Base Sequence; D002452:Cell Count; D002455:Cell Division; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D018546:Hypocotyl; D010641:Phenotype; D018515:Plant Leaves; D014157:Transcription Factors; D019076:Transgenes | The Plant journal : for cell and molecular biology | 2,002 | D029681:Arabidopsis Proteins; C480525:LEP protein, Arabidopsis; D014157:Transcription Factors; C480526:VAS protein, Arabidopsis |
Life experiences leading to the choice of surgery-A qualitative study exploring reasons behind the choice of undergoing gender affirmative surgery. | Objective
Gender dysphoria is frequently accompanied by physical dissatisfaction and body image issues. The primary objective of this study is to explore subjective experiences and perceptions among those who has undergone gender reassignment surgery, as well as their retrospective path to that decision.
Method
Sixte... | 10.3389/fsoc.2023.1226959 | 37,780,694 | Frontiers in sociology | 2,023 | ||
The relationship between grandmothers' involvement in child care and emergency department utilization. | This study examines the relationship between involvement of grandmothers in child care and poor urban mothers' use of the emergency department (ED) for nonurgent care. Mothers with an index child between one and two years old were interviewed in the waiting room of a pediatric continuity clinic. They were asked about t... | 10.1097/00006565-199508000-00008 | 8,532,567 | D000328:Adult; D001741:Black or African American; D017028:Caregivers; D002654:Child Care; D003139:Common Cold; D003430:Cross-Sectional Studies; D004636:Emergency Service, Hospital; D005190:Family; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015143:Philadelphia; D012944... | Pediatric emergency care | 1,995 | |
Vehicular traffic as a determinant of blood-lead levels in children: a pilot study in Mexico City. | The major determinants of blood-lead levels were studied in 90 children who attended an outpatient pediatric clinic in Mexico City. All children, who were from 1-10 y of age, were from homes for which socioeconomic status had been categorized as medium to high. Blood-lead levels ranged from 0.17 (standard deviation [SD... | 10.1080/00039896.1992.9938356 | 1,497,376 | D001334:Automobile Driving; D002648:Child; D002675:Child, Preschool; D003297:Cooking and Eating Utensils; D005260:Female; D005742:Gasoline; D006801:Humans; D007223:Infant; D007855:Lead Poisoning; D016014:Linear Models; D008297:Male; D008800:Mexico; D010044:Outpatient Clinics, Hospital; D010865:Pilot Projects; D012111:R... | Archives of environmental health | 1,992 | D005742:Gasoline |
Formation of resistant starch in deproteinized and non-deproteinized beans. | Resistant starch (RS) was determined in deproteinized and non-deproteinized whole and milled beans (Phaseolus vulgaris) after cooking and freezing. The highest RS values were obtained in the whole bean preparations (3.7-8.7%). Milled and milled and deproteinized beans presented lower RS contents (1.64% and 0.91%, respe... | 1,330,514 | D004043:Dietary Fiber; D007887:Fabaceae; D005511:Food Handling; D014674:Plant Proteins, Dietary; D010946:Plants, Medicinal; D013213:Starch | European journal of clinical nutrition | 1,992 | D004043:Dietary Fiber; D014674:Plant Proteins, Dietary; D013213:Starch | |
Advice of manufacturers about effects of temperature on biologicals. | Information was obtained from manufacturers on the stability of biologicals when exposed to higher-than-recommended temperatures, and procedures were developed for determining whether the quality of these products is compromised after such exposure. Questionnaires were sent to 24 manufacturers asking for product inform... | 4,014,237 | D000485:Allergens; D001688:Biological Products; D004345:Drug Industry; D004346:Drug Information Services; D004356:Drug Storage; D005615:Freezing; D012034:Refrigeration; D013696:Temperature | American journal of hospital pharmacy | 1,985 | D000485:Allergens; D001688:Biological Products | |
Stable self-assembled nanostructured hen egg white lysozyme exhibits strong anti-proliferative activity against breast cancer cells. | Chemotherapy side effects have long been a matter of great concern. Here we describe a structurally stable self-assembled nanostructured lysozyme (snLYZ) synthesized using a simple desolvation technique that exhibited anticancer activity, as well as excellent hemocompatibility. Field emission scanning electron microsco... | 25,935,265 | D016475:3T3 Cells; D000818:Animals; D001943:Breast Neoplasms; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002645:Chickens; D002942:Circular Dichroism; D004529:Egg White; D004795:Enzyme Stability; D005260:Female; D006461:Hemolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986... | Colloids and surfaces. B, Biointerfaces | 2,015 | D017382:Reactive Oxygen Species; C421864:hen egg lysozyme; D009113:Muramidase | |
Graphene-based metasurface solar absorber design with absorption prediction using machine learning. | Solar absorber is required to absorb most of the energy of the solar spectral irradiance. We propose a graphene-based solar absorber design with two different metasurfaces to improve this absorption and increase the efficiency of the solar absorber. The metasurfaces are selected based on their symmetrical/asymmetrical ... | 10.1038/s41598-022-06687-6 | 35,173,249 | Scientific reports | 2,022 | ||
Adult Age Differences in Sensitivity to Semantic Satiation. | OBJECTIVE
In this study, we investigated age differences in sensitivity to semantic satiation.Semantic satiation was conceptualized as occurring within a semantic activation framework.
METHOD
A prime or to-be-satiated word (e.g., ANIMAL) was presented repeatedly for an average of 2.5, 12.5, or 22.5 times. Afterward, ... | 10.1080/0361073X.2022.2048585 | 35,287,550 | D006801:Humans; D012660:Semantics; D000375:Aging; D011930:Reaction Time | Experimental aging research | 2,023 | |
Correlation Between Opioid Drug Prescription and Opioid-Related Mortality in Spain as a Surveillance Tool: Ecological Study. | BACKGROUND
Opioid drug prescription (ODP) and opioid-related mortality (ORM) have increased in Spain. However, their relationship is complex, as ORM is registered without considering the type of opioid (legal or illegal).
OBJECTIVE
This ecological study aimed to examine the correlation between ODP and ORM in Spain an... | 10.2196/43776 | 37,379,061 | D006801:Humans; D009293:Opioid-Related Disorders; D014147:Tramadol; D000701:Analgesics, Opioid; D000083682:Opiate Overdose; D011307:Drug Prescriptions; D005283:Fentanyl; D013030:Spain | JMIR public health and surveillance | 2,023 | D014147:Tramadol; D000701:Analgesics, Opioid; D005283:Fentanyl |
Deciphering Solution and Gas-Phase Interactions between Peptides and Lipids by Native Mass Spectrometry. | Many biological processes depend on the interactions between proteins and lipids. Accordingly, the analysis of protein-lipid complexes has become increasingly important. Native mass spectrometry is often used to identify and characterize specific protein-lipid interactions. However, it requires the transfer of the anal... | 10.1021/acs.analchem.3c03428 | 37,956,985 | D010455:Peptides; D013058:Mass Spectrometry; D011506:Proteins; D008055:Lipids | Analytical chemistry | 2,023 | D010455:Peptides; D011506:Proteins; D008055:Lipids |
Effects of self-talk: a systematic review. | This article presents a systematic review of the literature examining the relationship between self-talk and performance. "Second-generation questions" regarding potential mediators and moderators of the self-talk-performance relationship were also examined. A total of 47 studies were analyzed. Results indicated benefi... | 10.1123/jsep.33.5.666 | 21,984,641 | D000293:Adolescent; D000328:Adult; D056352:Athletes; D005260:Female; D006801:Humans; D008297:Male; D009042:Motivation; D012653:Self Stimulation; D013647:Task Performance and Analysis; D055815:Young Adult | Journal of sport & exercise psychology | 2,011 | |
Effect of the microstructure of a hyperbranched polymer and nanoclay loading on the morphology and properties of novel polyurethane nanocomposites. | Novel polyurethane nanocomposites based on toluene diisocyanate, poly(propylene glycol), various hyperbranched polymers (HBPs), and layered silicate were synthesized with the aim of determining the effect of the layered silicate loading and the functionality of HBP on the structure and properties of polyurethane nanoco... | 10.1021/am800020k | 20,353,216 | ACS applied materials & interfaces | 2,009 | ||
GABA content in the retina of pigmented and albino rats. | Reduction of the melanin precursor DOPA associated with albinism leads to spatiotemporal disturbances in retinal neurogenesis and thus seems to be responsible for numerous neuronal alterations found in albino retinae. To investigate whether these cellular alterations are reflected in retinal neurotransmitter concentrat... | 10.1097/00001756-200405190-00012 | 15,129,162 | D000417:Albinism; D000818:Animals; D005260:Female; D018698:Glutamic Acid; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D017208:Rats, Wistar; D012160:Retina; D013045:Species Specificity; D005680:gamma-Aminobutyric Acid | Neuroreport | 2,004 | D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid |
The TBI method preceding BMT at Innsbruck University Clinic for radiation therapy. | Thirteen TBIs have been performed prior to allogenic or autologous bone-marrow transplants in Innsbruck since August 1983 using a Linac (SL 75/20). Irradiation takes place from two lateral opposing fields with the patient lying in a dorsal position on a special couch on the wall (FSD = 350 cm). The mean dose of 10 Gy i... | 3,518,102 | D016026:Bone Marrow Transplantation; D006801:Humans; D008961:Models, Structural; D011879:Radiotherapy Dosage; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] | 1,986 | ||
Qualitative and quantitative analysis of human cytotoxic T-lymphocyte responses to HIV-1 proteins. | OBJECTIVE
To study the degree of immunogenicity of each HIV-1 protein.
DESIGN
In most viral systems, antiviral cytotoxic T-lymphocytes (CTL) from a given donor preferentially recognize only one or a small number of viral proteins.
METHODS
Anti-HIV CTL were generated by in vitro stimulation of peripheral blood monon... | 10.1097/00002030-199211000-00002 | 1,472,331 | D016915:AIDS Vaccines; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D066298:In Vitro Techniques; D012191:Retroviridae Proteins; D016176:T-Lymphocyte Subsets; D013602:T-Lymphocytes, Cytotoxic | AIDS (London, England) | 1,992 | D016915:AIDS Vaccines; D012191:Retroviridae Proteins |
Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes. | Five commonly used human cytochrome P450 (CYP) inhibitors were examined for their effects on coumarin 7-hydroxylase (CYP2A) activity in pig liver microsomes. The K(m) and V(max) values for coumarin 7-hydroxylation in pig liver microsomes were estimated to be 1 μm and 0.26 nmol·mg/min, respectively. The following human ... | 10.1111/j.1365-2885.2010.01262.x | 21,244,437 | D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D003374:Coumarins; D004791:Enzyme Inhibitors; D006900:Hydroxylation; D007093:Imidazoles; D008297:Male; D008862:Microsomes, Liver; D020033:Protein Isoforms; D013250:Steroid Hydroxylases; D013552:Swine | Journal of veterinary pharmacology and therapeutics | 2,011 | D003374:Coumarins; D004791:Enzyme Inhibitors; D007093:Imidazoles; D020033:Protein Isoforms; C517283:coumarin 7; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C029009:steroid hormone 7-alpha-hydroxylase |
An efficient algorithm to perform multiple testing in epistasis screening. | BACKGROUND
Research in epistasis or gene-gene interaction detection for human complex traits has grown over the last few years. It has been marked by promising methodological developments, improved translation efforts of statistical epistasis to biological epistasis and attempts to integrate different omics information... | 10.1186/1471-2105-14-138 | 23,617,239 | D000465:Algorithms; D003424:Crohn Disease; D004843:Epistasis, Genetic; D056726:Genetic Association Studies; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012984:Software | BMC bioinformatics | 2,013 | |
[Effect of carnosol against proliferative activity of breast cancer cells and its estrogen receptor subtype's mediation and regulation mechanisms]. | Carnosol has been proved to have anti-breast cancer effect in previous research. But its ER subtype's specific regulation and mediation mechanisms remain unclear. The aim of this study is to observe the effect of carnosol on cell proliferation and its estrogen receptor α and β's specific regulation and mediation mechan... | 25,522,625 | D045784:Abietanes; D015153:Blotting, Western; D001943:Breast Neoplasms; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004305:Dose-Response Relationship, Drug; D020847:Estrogen Receptor Modulators; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D005260:Female; D005434:Flow ... | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | 2,014 | C556295:4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol; D045784:Abietanes; D020847:Estrogen Receptor Modulators; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011720:Pyrazoles; D011743:Pyrimidines; C068623:carnosol | |
Histiocytic lymphoma: a report of a case with an unusual phenotype. | A 41-year-old female underwent a supraclavicular lymph node biopsy. Light microscopy showed a tumour with morphology suggestive of a malignant lymphoma arising from interdigitating reticulum cells (IDRC). Immunohistochemistry and enzyme histochemistry revealed the tumour cells not only to possess differentiation marker... | 10.1002/path.1711460204 | 3,891,942 | D000328:Adult; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes; D016403:Lymphoma, Large B-Cell, Diffuse; D008854:Microscopy, Electron; D010641:Phenotype | The Journal of pathology | 1,985 | |
Regime shifts of Mediterranean forest carbon uptake and reduced resilience driven by multidecadal ocean surface temperatures. | The mechanisms translating global circulation changes into rapid abrupt shifts in forest carbon capture in semi-arid biomes remain poorly understood. Here, we report unprecedented multidecadal shifts in forest carbon uptake in semi-arid Mediterranean pine forests in Spain over 1950-2012. The averaged carbon sink reduct... | 10.1111/gcb.14664 | 31,012,512 | D001267:Atlantic Ocean; D002244:Carbon; D065928:Forests; D009792:Oceans and Seas; D013030:Spain; D013696:Temperature | Global change biology | 2,019 | D002244:Carbon |
Patch Testing During Immunosuppressive Therapy: A Systematic Review. | Patch testing, used in the assessment of allergic contact dermatitis, is ideally avoided in patients receiving immunosuppressive therapy because of concerns with reductions in accuracy; however, this is not well characterized in the literature. This systematic review summarizes patch testing results in patients receivi... | 10.1097/DER.0000000000000726 | 33,896,928 | D017449:Dermatitis, Allergic Contact; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents; D010328:Patch Tests | Dermatitis : contact, atopic, occupational, drug | 2,021 | D007166:Immunosuppressive Agents |
Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor suppressor protein for prostate cancer. | Insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1) has been shown to have decreased expression in the progression from benign to malignant prostate epithelial cells (V. Hwa et al., J. Clin Endocrinol. Metab., 83: 4355-4362, 1998). The present study was undertaken to determine the effects of the re... | 10,344,746 | D000818:Animals; D017209:Apoptosis; D002352:Carrier Proteins; D002455:Cell Division; D048429:Cell Size; D018076:DNA, Complementary; D016147:Genes, Tumor Suppressor; D006801:Humans; D006918:Hydroxyurea; D018969:Insulin-Like Growth Factor Binding Proteins; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm ... | Cancer research | 1,999 | D002352:Carrier Proteins; D018076:DNA, Complementary; D018969:Insulin-Like Growth Factor Binding Proteins; D009363:Neoplasm Proteins; D011993:Recombinant Fusion Proteins; C102529:insulin-like growth factor binding protein-related protein 1; D006918:Hydroxyurea | |
Kaposi's sarcoma in renal transplantation: report of three cases. | Kaposi's sarcoma (KS) is one of the most common post transplant malignancies. A variety of factors appears to contribute to the development of KS including genetic factors, sex hormones, immunosuppression and oncogene viruses. We present 3 cases with concurrent KS and cytomegalovirus (CMV) infection in the first year a... | 10.5414/cnp71214 | 19,203,519 | D000328:Adult; D003586:Cytomegalovirus Infections; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012514:Sarcoma, Kaposi | Clinical nephrology | 2,009 | D007166:Immunosuppressive Agents |
Enhanced photocatalytic hydrogen evolution from organic semiconductor heterojunction nanoparticles. | Photocatalysts formed from a single organic semiconductor typically suffer from inefficient intrinsic charge generation, which leads to low photocatalytic activities. We demonstrate that incorporating a heterojunction between a donor polymer (PTB7-Th) and non-fullerene acceptor (EH-IDTBR) in organic nanoparticles (NPs)... | 10.1038/s41563-019-0591-1 | 32,015,530 | Nature materials | 2,020 | ||
Neurogenesis mediated by gamma-aminobutyric acid and glutamate signaling. | In this review, we will summarize our ongoing studies on the functionality of both gamma-aminobutyric acid (GABA) and glutamate receptors expressed by undifferentiated neural progenitor cells isolated from embryonic rodent brains. Cells were cultured with growth factors for the formation of round spheres by clustered c... | 10.1254/jphs.08r03cr | 19,483,378 | D000818:Animals; D018690:Excitatory Amino Acid Agonists; D018755:GABA Agonists; D018698:Glutamic Acid; D051379:Mice; D055495:Neurogenesis; D051381:Rats; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D015398:Signal Transduction; D005680:gamma-Aminobutyric Acid | Journal of pharmacological sciences | 2,009 | D018690:Excitatory Amino Acid Agonists; D018755:GABA Agonists; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid |
The cell wall architecture of Candida albicans wild-type cells and cell wall-defective mutants. | In Candida albicans wild-type cells, the beta1, 6-glucanase-extractable glycosylphosphatidylinositol (GPI)-dependent cell wall proteins (CWPs) account for about 88% of all covalently linked CWPs. Approximately 90% of these GPI-CWPs, including Als1p and Als3p, are attached via beta1,6-glucan to beta1,3-glucan. The remai... | 10.1046/j.1365-2958.2000.01729.x | 10,672,182 | D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002176:Candida albicans; D002473:Cell Wall; D002686:Chitin; D005656:Fungal Proteins; D005936:Glucans; D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins; D009154:Mutation; D029701:Saccharomyces cerevisiae Proteins; D047071... | Molecular microbiology | 2,000 | C093538:ALS1 protein, Candida albicans; C113620:ALS3 protein, Candida albicans; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005656:Fungal Proteins; D005936:Glucans; D017261:Glycosylphosphatidylinositols; C081933:KRE6 protein, S cerevisiae; D008565:Membrane Proteins; D029701:Sacch... |
Teaching chronic psychiatric inpatients to use differential attention to change each other's behaviors. | For nine months, all psychiatric inpatients who came into a 26-bed coed adult ward in a state hospital were taught the principles and application of differential attention to determine whether it could be a used as a significant therapeutic modality on a ward for chronic patients. In two half-hour classes each week, pa... | 10.1176/ps.41.4.425 | 2,332,228 | D000203:Activities of Daily Living; D000328:Adult; D001288:Attention; D001521:Behavior Therapy; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D010353:Patient Education as Topic; D011369:Professional-Patient Relations; D011567:Psychiatric Department, Hospital; D0... | Hospital & community psychiatry | 1,990 | |
[The dependence of stability of the green fluorescent protein-obelin hybrids on the nature of their constituent modules and the structure of the amino acid linker]. | Recombinant plasmids containing genes for the green fluorescent protein (GFP) from Aequorea victoria and the photoprotein obelin from Obelia longissima linked in-frame by inserts differing in nucleotide sequences were constructed. The expression of the chimeric genes in Escherichia coli cells resulted in synthesis of t... | 10.1023/a:1012344414924 | 11,641,911 | D000596:Amino Acids; D000818:Animals; D004926:Escherichia coli; D049452:Green Fluorescent Proteins; D006868:Hydrolysis; D008164:Luminescent Proteins; D016364:Reading Frames; D011993:Recombinant Fusion Proteins; D037401:Scyphozoa; D014357:Trypsin | Bioorganicheskaia khimiia | 2,001 | D000596:Amino Acids; D008164:Luminescent Proteins; D011993:Recombinant Fusion Proteins; C010497:obelin; D049452:Green Fluorescent Proteins; D014357:Trypsin |
Anti-opioid systems in morphine tolerance and addiction--locus-specific involvement of nociceptin and the NMDA receptor. | Mechanisms for opioid tolerance and addiction are divided into two types of plasticity--cellular level and those occurring through multiple neuronal networks. Receptor desensitization through phosphorylation and endocytosis are currently well discussed using cell lines expressing opioid receptors in relation to acute t... | 15,469,049 | D000818:Animals; D001921:Brain; D000242:Cyclic AMP; D006801:Humans; D051379:Mice; D008959:Models, Neurological; D009021:Morphine Dependence; D009473:Neuronal Plasticity; D018847:Opioid Peptides; D011493:Protein Kinase C; D016194:Receptors, N-Methyl-D-Aspartate; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor;... | Novartis Foundation symposium | 2,004 | D018847:Opioid Peptides; D016194:Receptors, N-Methyl-D-Aspartate; D011957:Receptors, Opioid; D000242:Cyclic AMP; D011493:Protein Kinase C; D000094942:Nociceptin Receptor | |
Evaluation of endothelial and inducible nitric oxide synthase mRNA expression in the lung of broiler chickens with developmental pulmonary hypertension due to cold stress. | To clarify the effect of cold-induced pulmonary hypertension on endothelial and inducible nitric oxide synthase (eNOS and iNOS) mRNA expression in the lung of broiler chickens, semi quantitative reverse transcription-PCR was performed on total RNAs isolated from lungs of the broiler chickens exposed to 5 weeks of cold ... | 10.1080/00071660600611169 | 16,641,034 | D000375:Aging; D000818:Animals; D002645:Chickens; D003080:Cold Temperature; D015971:Gene Expression Regulation, Enzymologic; D006976:Hypertension, Pulmonary; D008168:Lung; D008297:Male; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D011201:Poultry Diseases; D012333:RNA, Messenger; D0201... | British poultry science | 2,006 | D012333:RNA, Messenger; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III |
Characterization of Lumbar Spine Annular Disruption in PMHS Using MRI, Cryomicrotomy and Histology Techniques. | Internal intervertebral disc disruption is involved in the onset of a wide range of spinal dysfunction, ultimately affecting not only the disc itself but the surrounding osseous and neural structures as well. The ability of disc to withstand and effectively distribute axial load is dependent upon whether peripherally l... | 25,996,731 | Biomedical sciences instrumentation | 2,015 | |||
The U6 gene of Saccharomyces cerevisiae is transcribed by RNA polymerase C (III) in vivo and in vitro. | Unlike the majority of genes encoding small nuclear RNAs, which are transcribed by RNA polymerase B, the U6 gene contains features found in both class B and class C genes, indicating the involvement of a combination of transcription factors normally specific to each class of genes. We present direct genetic and biochem... | 10.1002/j.1460-2075.1990.tb08105.x | 2,403,927 | D001483:Base Sequence; D012321:DNA-Directed RNA Polymerases; D008969:Molecular Sequence Data; D009154:Mutation; D009693:Nucleic Acid Hybridization; D012320:RNA Polymerase III; D012341:RNA, Ribosomal, 5S; D012342:RNA, Small Nuclear; D012343:RNA, Transfer; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae; D0... | The EMBO journal | 1,990 | D012341:RNA, Ribosomal, 5S; D012342:RNA, Small Nuclear; D035361:Transcription Factor TFIIIB; D014157:Transcription Factors; D012343:RNA, Transfer; D012321:DNA-Directed RNA Polymerases; D012320:RNA Polymerase III; D015719:Single-Strand Specific DNA and RNA Endonucleases |
MicroRNA-328 is involved in the effect of selenium on hydrogen peroxide-induced injury in H9c2 cells. | Oxidative stress induces apoptosis in cardiac cells, and antioxidants attenuate the injury. MicroRNAs (miRNAs) are also involved in cell death; therefore, this study aimed to investigate the role of miRNAs in the effect of selenium on oxidative stress-induced apoptosis. The effects of sodium selenite were analyzed via ... | 10.1002/jbt.21920 | 28,544,404 | D000818:Animals; D017209:Apoptosis; D020013:Calcium Signaling; D002460:Cell Line; D002470:Cell Survival; D005979:Glutathione Peroxidase; D006861:Hydrogen Peroxide; D008315:Malondialdehyde; D035683:MicroRNAs; D032386:Myoblasts, Cardiac; D054464:Peroxiredoxins; D051381:Rats; D012643:Selenium; D018038:Sodium Selenite; D01... | Journal of biochemical and molecular toxicology | 2,017 | D035683:MicroRNAs; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D054464:Peroxiredoxins; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D018038:Sodium Selenite |
A Retrospective Analysis on the Cystic Echinococcosis Cases Occured in Northeastern Punjab Province, Pakistan. | A retrospective study was performed to report the case occurrence of cystic echinococcosis (CE) in three hospitals of north-eastern region in Punjab Province, Pakistan. We reviewed retrospectively the clinical records of patients in 4 hospitals which were diagnosed with CE during 2012-2017. A total of 198 cases, 82 (41... | 10.3347/kjp.2018.56.4.385 | 30,196,673 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004443:Echinococcosis; D004444:Echinococcosis, Hepatic; D004445:Echinococcosis, Pulmonary; D005260:Female; D006761:Hospitals; D006801:Humans; D015994:Incidence; D008099:Liver; D008168:Lung; D008297:Male; D00... | The Korean journal of parasitology | 2,018 | |
Chronic aortic regurgitation: a demonstration of the effect of bradycardia on left ventricular function. | A 50-year-old man with previously asymptomatic aortic regurgitation presented with clinical, echocardiographic and hemodynamic deterioration secondary to bradycardia. The effects of prolonged diastolic time were demonstrated in the catheterization laboratory; immediate improvement in left ventricular end diastolic and ... | 2,310,991 | D001022:Aortic Valve Insufficiency; D001919:Bradycardia; D002908:Chronic Disease; D006327:Heart Block; D006352:Heart Ventricles; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial | The Canadian journal of cardiology | 1,990 | ||
Prevalence and clinical impact of recreational drug consumption in people living with HIV on treatment: a cross-sectional study. | OBJECTIVES
Drug interactions, poor adherence to medication and high-risk sexual behaviour may occur in individuals with HIV using recreational drugs. Thus, we aimed to assess the prevalence of recreational drugs use and to explore its clinical impact in HIV patients on treatment.
METHODS
Observational, cross sectiona... | 10.1136/bmjopen-2016-014105 | 28,100,565 | D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents; D015496:CD4-Positive T-Lymphocytes; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections; D006801:Humans; D013287:Illicit Drugs; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D015995:Prevalence; D012309:Risk-Taking; D01272... | BMJ open | 2,017 | D019380:Anti-HIV Agents; D013287:Illicit Drugs |
A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis. | Fumaric acid esters (FAEs) such as dimethylfumarate (DMF) are used for the treatment of adults with moderate-to-severe psoriasis. The mode of action of FAEs is complex. Here, we provide a comprehensive review of the literature to describe the molecular mechanisms by which DMF and its active metabolite monomethylfumarat... | 10.1111/exd.13548 | 29,603,404 | D000818:Animals; D016207:Cytokines; D003879:Dermatologic Agents; D000069462:Dimethyl Fumarate; D015536:Down-Regulation; D042783:Endothelial Cells; D005978:Glutathione; D006801:Humans; D015603:Keratinocytes; D008214:Lymphocytes; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; D009504:Neutrophils; D011565:Psoriasis; ... | Experimental dermatology | 2,018 | D016207:Cytokines; D003879:Dermatologic Agents; C530636:HCAR2 protein, human; C473652:Hcar2 protein, mouse; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495635:NFE2L2 protein, human; D043562:Receptors, G-Protein-Coupled; D000069462:Dimethyl Fumarate; D005978:Glutathione |
Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19. | Alternative branches of the classical renin-angiotensin-aldosterone system (RAS) represent an important cascade in which angiotensin 2 (AngII) undergoes cleavage via the action of the angiotensin-converting enzyme 2 (ACE2) with subsequent production of Ang(1-7) and other related metabolites eliciting its effects via Ma... | 10.3390/ijms222312800 | 34,884,604 | D000803:Angiotensin I; D000804:Angiotensin II; D000085962:Angiotensin-Converting Enzyme 2; D000818:Animals; D000086382:COVID-19; D006801:Humans; D000860:Hypoxia; D008168:Lung; D009203:Myocardial Infarction; D010446:Peptide Fragments; D012084:Renin-Angiotensin System; D000086402:SARS-CoV-2 | International journal of molecular sciences | 2,021 | D010446:Peptide Fragments; D000804:Angiotensin II; D000803:Angiotensin I; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2; C118790:angiotensin I (1-7) |
A previously-unknown Iranian treatise on a terrestrial globe. | This paper introduces an unusual text from 17th century Iran: Āqā Raḍī's work, Qiblat al-āfāq. The treatise offers an insight into the making and use of terrestrial globes. The most interesting section of the text is a series of instructions for making terrestrial globes. The fact that no such instrument from the Ṣafav... | 10.1016/j.shpsa.2022.07.007 | 36,099,855 | D006801:Humans; D007492:Iran; D007514:Islam; D008297:Male | Studies in history and philosophy of science | 2,022 | |
Adenosine-induced chest pain: is it due to myocardial ischaemia? Clinical, electrocardiographic, haemodynamic and metabolic study. | Adenosine has recently been demonstrated to be a mediator of angina in human beings. The present study was undertaken to document the presence or absence of myocardial ischaemia on clinical, haemodynamic, electrocardiographic and metabolic evidences after intracoronary administration of adenosine. Fifteen patients with... | 9,291,647 | D000241:Adenosine; D000787:Angina Pectoris; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007261:Infusions, Intra-Arterial; D019157:Ischemic Preconditioning, Myocardial; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia; D011669:Pulmonary Wedge Pre... | Indian heart journal | 1,997 | D018047:Receptors, Purinergic P1; D019344:Lactic Acid; D000241:Adenosine | |
Vertebral Body Tethering in AIS Management-A Preliminary Report. | Vertebral Body Tethering (VBT) is a recently developed surgical technique for the treatment of progressive and severe scoliosis in patients with significant growth potential. It has been used since the first exploratory series, which showed encouraging results on the progressive correction of the major curves. This stu... | 10.3390/children10020192 | 36,832,321 | Children (Basel, Switzerland) | 2,023 | ||
CD40/CD40L Signaling as a Promising Therapeutic Target for the Treatment of Renal Disease. | The cluster of differentiation 40 (CD40) is activated by the CD40 ligand (CD40L) in a variety of diverse cells types and regulates important processes associated with kidney disease. The CD40/CD40L signaling cascade has been comprehensively studied for its roles in immune functions, whereas the signaling axis involved ... | 10.3390/jcm9113653 | 33,202,988 | Journal of clinical medicine | 2,020 | ||
Age-related changes in brain regional activity during chewing: a functional magnetic resonance imaging study. | Age-related changes in mastication-induced brain neuronal activity have been suggested. However, in humans, little is known about the anatomical regions involved. Using fMRI during cycles of rhythmic gum-chewing and no chewing, we have examined the effect of aging on brain regional activity during chewing in young adul... | 10.1177/154405910308200817 | 12,885,854 | D000328:Adult; D000368:Aged; D000375:Aging; D000704:Analysis of Variance; D001921:Brain; D002531:Cerebellum; D002540:Cerebral Cortex; D002638:Chewing Gum; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008409:Mastication; D008875:Middle Ag... | Journal of dental research | 2,003 | D002638:Chewing Gum |
Towards understanding the role of sialylation in melanoma progression. | Aberrant expression of sialic acids or altered linkage types is closely associated with malignant phenotype and metastatic potential, and can have prognostic significance in human cancer. The present study was undertaken to evaluate whether expression of sialylated derivatives on melanoma cell surface is associated wit... | 27,474,400 | D045744:Cell Line, Tumor; D018450:Disease Progression; D015870:Gene Expression; D006031:Glycosylation; D006801:Humans; D008545:Melanoma; D019158:N-Acetylneuraminic Acid; D010641:Phenotype; D011499:Protein Processing, Post-Translational; D012799:Sialyltransferases; D012878:Skin Neoplasms | Acta biochimica Polonica | 2,016 | D012799:Sialyltransferases; D019158:N-Acetylneuraminic Acid | |
Stimulation of the hypothalamic paraventricular nucleus produces analgesia not mediated by vasopressin or endogenous opioids. | The analgesic effect of electrical stimulation of the hypothalamic paraventricular nucleus (PVN) was studied. Additionally, the involvement of vasopressin and opioid peptides in this process was examined by comparing vasopressin-deficient (Brattleboro) and Long-Evans rats and by administering the opiate antagonist nalo... | 10.1016/0006-8993(90)90354-e | 1,982,239 | D000698:Analgesia; D000818:Animals; D001933:Brain Stem; D003919:Diabetes Insipidus; D004399:Dynorphins; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004723:Endorphins; D008297:Male; D009270:Naloxone; D010286:Paraventricular Hypothalamic Nucleus; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, In... | Brain research | 1,990 | D004723:Endorphins; D014667:Vasopressins; D009270:Naloxone; D004399:Dynorphins |
Mobilization of intracellular calcium and stimulation of calcium fluxes by endothelin-2 in cultured mouse swiss 3T3 fibroblasts. | Specific receptor-induced signal transduction mechanisms for the endothelin-2 isoform (ET-2), a potent vasoconstrictor of vascular smooth muscle, were examined in Swiss 3T3 cells. Half-maximal binding (EC(50)) and maximal, saturable binding (B(max)) were estimated from Scatchard analyses and were found to be 24.2 +/- 3... | 10.1016/0197-0186(91)90159-b | 20,504,745 | Neurochemistry international | 1,991 | ||
Normal renal artery spectral Doppler waveform: a closer look. | PURPOSE
To characterize the spectral Doppler tracing of the normal renal artery.
MATERIALS AND METHODS
Doppler tracings were obtained from a phantom of a vessel with variable compliance and from the kidneys of 15 healthy volunteers.
RESULTS
In the phantom, vascular compliance had the following effects on systolic f... | 10.1148/radiology.196.3.7644627 | 7,644,627 | D000054:Acceleration; D000328:Adult; D001783:Blood Flow Velocity; D006801:Humans; D008961:Models, Structural; D015588:Observer Variation; D011673:Pulsatile Flow; D011674:Pulse; D012039:Regional Blood Flow; D012077:Renal Artery; D016037:Single-Blind Method; D013599:Systole; D018608:Ultrasonography, Doppler; D014655:Vasc... | Radiology | 1,995 | |
Using reduced density matrix techniques to capture static and dynamic correlation in the energy landscape for the decomposition of the CH2CH2ONO radical and support a non-IRC pathway. | The unexpected abundance of HNO in the photodecomposition of the radical 2-nitrosooxy ethyl (CH2CH2ONO) is investigated through calculations of the potential energy surface by the anti-Hermitian contracted Schrödinger equation (ACSE) method, which directly generates the 2-electron reduced density matrix. The ACSE, whic... | 10.1063/1.5024512 | 30,007,389 | The Journal of chemical physics | 2,018 | ||
Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. | The human myeloid cell nuclear differentiation antigen (MNDA) is expressed constitutively in cells of the myeloid lineage, appearing in myeloblast cells in some cases of acute myeloid leukemia and consistently being detected in promyelocyte stage cells as well as in all later stage cells including peripheral blood mono... | 10.1002/jcb.240540208 | 8,175,894 | D015214:Antigens, Differentiation, Myelomonocytic; D001483:Base Sequence; D002453:Cell Cycle; D002454:Cell Differentiation; D006098:Granulocytes; D006801:Humans; D016898:Interferon-alpha; D007951:Leukemia, Myeloid; D008969:Molecular Sequence Data; D009000:Monocytes; D014157:Transcription Factors; D014407:Tumor Cells, C... | Journal of cellular biochemistry | 1,994 | D015214:Antigens, Differentiation, Myelomonocytic; D016898:Interferon-alpha; C075373:MNDA protein, human; D014157:Transcription Factors |
An empirical investigation of the 'Biopsychosocial Disease Consequence model': psychological impairment, disability and handicap in chronic pain patients. | The purpose of this study is to emphasize the meaningfulness of a global, functional rather than a narrow medical view in the efficacy evaluation of chronic pain treatment. Therefore, the 'Biopsychosocial Disease Consequence (BPSDC) model' to assess function more globally than before, is presented in this article. The ... | 10.3109/09638289509166648 | 7,579,478 | D000328:Adult; D002908:Chronic Disease; D006233:Disabled Persons; D005260:Female; D006801:Humans; D017116:Low Back Pain; D008297:Male; D001523:Mental Disorders; D008875:Middle Aged; D008960:Models, Psychological; D017063:Outcome Assessment, Health Care; D011581:Psychological Tests | Disability and rehabilitation | 1,995 | |
Chemogenic Subqualities of Mouthfeel. | Mouthfeel refers to the physical or textural sensations in the mouth caused by foods and beverages that are essential to the acceptability of many edible products. The sensory subqualities contributing to mouthfeel are often chemogenic in nature and include heat, burning, cooling, tingling, and numbing. These "chemesth... | 10.1093/chemse/bjz016 | 31,039,245 | D006801:Humans; D009055:Mouth; D018035:Receptors, Odorant; D012677:Sensation; D013649:Taste; D014276:Trigeminal Nerve | Chemical senses | 2,019 | D018035:Receptors, Odorant |
Entropy in Image Analysis III. | Image analysis basically refers to any extraction of information from images, which can be as simple as QR codes required in logistics and digital certifications or related to large and complex datasets, such as the collections of images used for biometric identification or the sets of satellite surveys employed in the... | 10.3390/e23121648 | 34,945,954 | Entropy (Basel, Switzerland) | 2,021 |
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