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[Bioinformatics analysis of drug-resistant ceRNA in epithelial ovarian cancer]. | Objective: To explore the possible biological function of long-chain non-coding RNA (lncRNA) on epithelial ovarian cancer (EOC) drug resistance and the value of new diagnostic markers through bioinformatics analysis, clinical testing and verification methods. Methods: (1) Mining the lncRNA related to EOC and constructi... | 10.3760/cma.j.cn112141-20200718-00587 | 33,631,884 | D000077216:Carcinoma, Ovarian Epithelial; D002681:China; D019295:Computational Biology; D019008:Drug Resistance, Neoplasm; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D010051:Ovarian Neoplasms; D016133:Polymerase Chain Reaction; D062085:RNA, Long Non... | Zhonghua fu chan ke za zhi | 2,021 | D062085:RNA, Long Noncoding |
Genital plus audiovisual sexual stimulation following intracavernous vasoactive injection versus re-dosing for erectile dysfunction--results of a prospective study. | PURPOSE
We assessed whether re-dosing of a vasoactive agent or the combination of a vasoactive injection and genital plus audiovisual sexual stimulation caused the greatest erectile effect to determine which of the 2 procedures would be better for dynamic penile color Doppler sonography in patients with erectile dysfun... | 10.1016/s0022-5347(01)64029-1 | 9,400,449 | D000328:Adult; D000368:Aged; D000527:Alprostadil; D001296:Audiovisual Aids; D018592:Cross-Over Studies; D007172:Erectile Dysfunction; D004882:Erotica; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010410:Penile Erection; D010775:Photic Stimulation; D010812:Physical Stimulation; D011446:Prospec... | The Journal of urology | 1,998 | D014665:Vasodilator Agents; D000527:Alprostadil |
Atrial fibrillation and pneumothorax after transthoracic needle lung biopsy. | An obese 65-year-old male smoker with chronic obstructive pulmonary disease developed an iatrogenic pneumothorax with pulmonary haemorrhage during an elective transthoracic needle biopsy of a pulmonary lesion. Successful re-inflation was achieved with a chest drain which was then removed before transfer to the medical ... | 22,665,868 | D000368:Aged; D001281:Atrial Fibrillation; D001707:Biopsy, Needle; D015505:Chest Tubes; D004322:Drainage; D004562:Electrocardiography; D006801:Humans; D008168:Lung; D008297:Male; D011030:Pneumothorax; D013617:Tachycardia, Supraventricular | BMJ case reports | 2,012 | ||
Duloxetine Protects Human Neuroblastoma Cells from Oxidative Stress-Induced Cell Death Through Akt/Nrf-2/HO-1 Pathway. | The contribution of oxidative stress to the pathophysiology of depression has been described in numerous studies. Particularly, an increased production of reactive oxygen species (ROS) caused by mitochondrial dysfunction can lead to neuronal cell death. Human neuroblastoma SH-SY5Y cells were used to investigate the neu... | 10.1007/s11064-017-2433-3 | 29,134,401 | D017209:Apoptosis; D016923:Cell Death; D045744:Cell Line, Tumor; D000068736:Duloxetine Hydrochloride; D051547:Heme Oxygenase-1; D006801:Humans; D009447:Neuroblastoma; D018696:Neuroprotective Agents; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D017382:Reactive Oxygen Species; D012402:R... | Neurochemical research | 2,018 | D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D012402:Rotenone; D000068736:Duloxetine Hydrochloride; D051547:Heme Oxygenase-1; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt |
Efficiency gains from the addition of controls to matched sets in cohort studies. | We evaluate relative efficiencies of added controls in matched cohort studies in terms of the asymptotic variance of the estimate of the log relative risk associated with a single binary exposure variable. We calculate expected contributions to the information based on the Cox proportional hazards model under the assum... | 10.1002/sim.4780080808 | 2,799,126 | D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D004526:Efficiency; D015233:Models, Statistical; D011336:Probability; D012107:Research Design; D012306:Risk; D012494:Sampling Studies | Statistics in medicine | 1,989 | |
Effects of Spatial Stimulus Overlap in a Visual P300-based Brain-computer Interface. | The rapid serial visual presentation (RSVP) paradigm seems to be one of the most appropriate for patients using P300-based brain-computer interface (BCI) applications, since non-ocular movements are required. However, according to previous works, the use of different locations for each stimulus may improve performance.... | 10.1016/j.neuroscience.2020.02.011 | 32,081,721 | D062207:Brain-Computer Interfaces; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D005133:Eye Movements; D006801:Humans; D010775:Photic Stimulation; D014584:User-Computer Interface | Neuroscience | 2,020 | |
Hydrogen-bonded sheets in racemic cis-(2,2'-bipyridyl-kappa2N,N')oxo(pentane-2,4-dionato-kappa2O,O')(thiocyanato-kappaN)vanadium(IV). | The title compound, [V(C5H7O2)(NCS)O(C10H8N2)], crystallizes with Z' = 2 in the space group Pbca. The molecules are linked into sheets by a combination of four C-H...O hydrogen bonds and one C-H...N hydrogen bond. The four C-H...O hydrogen bonds generate chains of rings, where each chain contains just a single enantiom... | 10.1107/S0108270106008158 | 16,679,575 | Acta crystallographica. Section C, Crystal structure communications | 2,006 | ||
Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6. | The purpose of this study was to characterize the mutant enzyme in nine patients with gyrate atrophy of the choroid and retina associated with ornithine aminotransferase (OAT) deficiency, to elucidate the mechanism of response to pyridoxine in four pyridoxine-responsive patients, and to determine the extent of genetic ... | 2,916,580 | D001284:Atrophy; D002478:Cells, Cultured; D002829:Choroid; D004795:Enzyme Stability; D006801:Humans; D007700:Kinetics; D009154:Mutation; D009953:Ornithine-Oxo-Acid Transaminase; D011736:Pyridoxine; D012160:Retina; D012162:Retinal Degeneration; D013577:Syndrome; D000637:Transaminases; D014603:Uveal Diseases | American journal of human genetics | 1,989 | D000637:Transaminases; D009953:Ornithine-Oxo-Acid Transaminase; D011736:Pyridoxine | |
Red yeast rice fermentation by selected Monascus sp. with deep-red color, lovastatin production but no citrinin, and effect of temperature-shift cultivation on lovastatin production. | Monascus pilosus NBRC4520 was selected for functional fermented food inoculation for its high lovastatin and low citrinin production with a deep-red color. For koji (mold rice) with high lovastatin production, separation of the growth phase and lovastatin production phase by shifting the temperature from 30 to 23 degre... | 10.1007/s12010-009-8553-8 | 19,214,788 | D001688:Biological Products; D002953:Citrinin; D005285:Fermentation; D008148:Lovastatin; D032741:Monascus; D013696:Temperature | Applied biochemistry and biotechnology | 2,009 | D001688:Biological Products; C117343:red yeast rice; D002953:Citrinin; D008148:Lovastatin |
Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins. | PURPOSE
Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness.
METH... | 10.1167/iovs.14-14339 | 24,764,060 | D000328:Adult; D000368:Aged; D058966:Contactins; D004247:DNA; D056915:DNA Copy Number Variations; D005006:Ethnicity; D005260:Female; D017353:Gene Deletion; D020440:Gene Duplication; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D005902:Glaucoma, Open-Angle; D006801:Humans; D007194:... | Investigative ophthalmology & visual science | 2,014 | C098304:CNTN4 protein, human; D058966:Contactins; D004247:DNA |
Enhanced Golic+: highly effective CRISPR gene targeting and transgene HACKing in Drosophila. | Gene targeting is an incredibly valuable technique. Sometimes, however, it can also be extremely challenging for various intrinsic reasons (e.g. low target accessibility or nature/extent of gene modification). To bypass these barriers, we designed a transgene-based system in Drosophila that increases the number of inde... | 10.1242/dev.181974 | 32,467,238 | D000818:Animals; D030801:Animals, Genetically Modified; D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D004330:Drosophila; D029721:Drosophila Proteins; D005260:Female; D018390:Gene Targeting; D005854:Germ Cells; D008297:Male; D011401:Promoter Regions, Genetic; D017394:RNA, Guide, Kinetoplastida; D01... | Development (Cambridge, England) | 2,020 | D029721:Drosophila Proteins; C557617:GAL4 protein, Drosophila; D017394:RNA, Guide; D014157:Transcription Factors; C091674:bam protein, Drosophila |
Health effects of arsenic in drinking water: Research needs. | Research needed to resolve the uncertainties of cancer risk from ingestion of arsenic in drinking water is described. The recommendations fall into two categories reflecting the areas of greatest uncertainty regarding the assessment of arsenic risk: research on the mechanism of cancer, and research on the metabolism an... | 10.1007/BF01783631 | 24,197,929 | Environmental geochemistry and health | 1,992 | ||
Antimicrobial susceptibility of Actinobacillus pleuropneumoniae, Pasteurella multocida and Salmonella choleraesuis isolates from pigs. | The in vitro susceptibility of 839 isolates of Actinobacillus pleuropneumoniae, 969 isolates of Pasteurella multocida and 104 isolates of Salmonella choleraesuis from pigs to the fluoroquinolone danofloxacin, and eight other commonly used antimicrobial drugs was determined by veterinary diagnostic laboratories in Europ... | 10.1136/vr.134.1.5 | 8,128,570 | D000189:Actinobacillus Infections; D016977:Actinobacillus pleuropneumoniae; D000818:Animals; D000900:Anti-Bacterial Agents; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D010326:Pasteurella Infections; D016979:Pasteurella multocida; D012475:Salmonella; D012... | The Veterinary record | 1,994 | D000900:Anti-Bacterial Agents |
Label-free and sensitive electrogenerated chemiluminescence aptasensor for the determination of lysozyme. | A novel label-free electrogenerated chemiluminescence (ECL) aptasensor for the determination of lysozyme is designed employing lysozyme binding aptamer (LBA) as molecular recognition element for lysozyme as a model analyte and Ru(bpy)(3)(2+) as an ECL signal compound. This ECL aptasensor was fabricated by self-assembli... | 10.1016/j.bios.2010.09.048 | 21,030,242 | D052157:Aptamers, Nucleotide; D015374:Biosensing Techniques; D003217:Conductometry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008163:Luminescent Measurements; D009113:Muramidase; D013194:Staining and Labeling | Biosensors & bioelectronics | 2,011 | D052157:Aptamers, Nucleotide; D009113:Muramidase |
Effects of epidemiology learning software on nursing and midwifery students. | BACKGROUND
Being informed of new methods of teaching and comparing their outcome help teachers use more effective and efficient methods in developing and implementing new training courses. The aim of this study was to examine the efficacy of epidemiology learning software on learning epidemiology courses.
METHODS
Thi... | 25,694,995 | Medical journal of the Islamic Republic of Iran | 2,014 | |||
Neurological involvement in a case of hypophosphatemia. | Hypophosphatemia occasionally underlies neurological disorders such as encephalopathy, myopathy and neuropathy. Although several cases have been reported in the literature, severe hypophosphatemia as a cause of neurological disorders is rarely mentioned in neurological textbooks and is seldom thought of in practice. We... | 10.1016/s0953-6205(03)00098-0 | 13,678,759 | European journal of internal medicine | 2,003 | ||
Computational approaches to the in vitro antibacterial activity of Allium hirtifolium Boiss against gentamicin-resistant Escherichia coli: focus on ribosome recycling factor. | Persian shallot, Allium hirtifolium Boiss. (AH), is an Iranian native medicinal plant belongs to Alliaceae family. Here, we investigated in vitro antibacterial activity of hydro-alcoholic extract derived from bulbs of AH. We also employed in silico molecular docking to decipher mechanisms of its antibacterial effects. ... | 10.1007/s40203-017-0027-z | 28,924,532 | In silico pharmacology | 2,016 | ||
Ehrlichia chaffeensis and Its Invasin EtpE Block Reactive Oxygen Species Generation by Macrophages in a DNase X-Dependent Manner. | The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most genes that confer resistance to oxidative stress but can block reactive oxygen species (ROS) generation by host monocytes-macrophages. Bacterial and host molecules responsible for this inhibition have not been identified. To infect host cells, Ehrli... | 10.1128/mBio.01551-17 | 29,162,709 | D018829:Adhesins, Bacterial; D000818:Animals; D003851:Deoxyribonucleases; D018469:Ehrlichia chaffeensis; D006801:Humans; D008264:Macrophages; D051379:Mice; D009000:Monocytes; D009504:Neutrophils; D017382:Reactive Oxygen Species; D015398:Signal Transduction | mBio | 2,017 | D018829:Adhesins, Bacterial; D017382:Reactive Oxygen Species; D003851:Deoxyribonucleases |
Implementing guidelines for interdisciplinary care of low back pain: a critical role for pre-appointment management of specialty referrals. | BACKGROUND
Improving health care will require more effective guideline implementation and redesign of delivery processes and systems. Patient referral for specialty care is a key component of health system function that needs to be improved. Low back pain care is a widely documented example of the need for improvement.... | 10.1016/s1070-3241(01)27055-2 | 11,765,382 | D000208:Acute Disease; D000465:Algorithms; D001071:Appointments and Schedules; D002908:Chronic Disease; D019983:Guideline Adherence; D006801:Humans; D017116:Low Back Pain; D009985:Orthopedics; D017063:Outcome Assessment, Health Care; D017060:Patient Satisfaction; D017410:Practice Guidelines as Topic; D011320:Primary He... | The Joint Commission journal on quality improvement | 2,001 | |
Effective nursing care of adolescents diagnosed with anorexia nervosa: the patients' perspective. | AIMS AND OBJECTIVES
The purpose of this study is to develop - from the patients' perspective - a tentative theoretical model explaining the effectiveness of inpatient nursing care of adolescents diagnosed with anorexia nervosa.
BACKGROUND
The continuous and direct involvement of nurses with patients is likely to play... | 10.1111/j.1365-2702.2009.02821.x | 19,538,553 | D000293:Adolescent; D000856:Anorexia Nervosa; D006801:Humans; D008962:Models, Theoretical; D016896:Treatment Outcome | Journal of clinical nursing | 2,009 | |
Household bed net ownership and use among under-5 children in Nigeria. | BACKGROUND
Malaria remains the leading cause of morbidity and mortality in sub-Saharan Africa, with children under 5 years accounting for 86% of all malaria deaths. For effective control of malaria, WHO recommends rapid diagnosis and effective treatment, insecticide-treated bed nets, and indoor residual spraying. The u... | 10.2147/RRTM.S45586 | 30,890,872 | Research and reports in tropical medicine | 2,013 | ||
Effect of mechanical removal of the pulp upon the retention of odontoblasts around the pulp chamber of human third molars. | The pulp chambers of 11 freshly extracted human third molars were exposed by cutting off the roots apical to the cervical margin and the pulps were either removed with forceps and discarded or left in situ. The teeth were fixed, demineralized, divided longitudinally, embedded in resin and 2-micron sections stained with... | 10.1016/s0003-9969(96)00060-x | 9,022,929 | D002448:Cell Adhesion; D003782:Dental Pulp; D003786:Dental Pulp Cavity; D003804:Dentin; D003806:Dentin Permeability; D005353:Fibronectins; D006801:Humans; D008964:Molar, Third; D009804:Odontoblasts; D011670:Pulpectomy | Archives of oral biology | 1,996 | D005353:Fibronectins |
Tandem repeats are involved in G1 domain inhibition of versican expression and secretion and the G3 domain enhances glycosaminoglycan modification and product secretion via the complement-binding protein-like motif. | The large aggregating chondroitin sulfate proteoglycans, including aggrecan, versican (PG-M), neurocan, and brevican, are characterized by N-terminal and C-terminal globular (or selectin-like) domains known as the G1 and G3 domains, respectively. For this study, we generated a series of expression constructs containing... | 10.1074/jbc.M001443200 | 10,801,813 | D000818:Animals; D001665:Binding Sites; D019556:COS Cells; D002645:Chickens; D011508:Chondroitin Sulfate Proteoglycans; D003165:Complement System Proteins; D006025:Glycosaminoglycans; D037181:Lectins, C-Type; D016297:Mutagenesis, Site-Directed; D011509:Proteoglycans; D011994:Recombinant Proteins; D020449:Repetitive Seq... | The Journal of biological chemistry | 2,000 | D011508:Chondroitin Sulfate Proteoglycans; D006025:Glycosaminoglycans; D037181:Lectins, C-Type; D011509:Proteoglycans; D011994:Recombinant Proteins; D053675:Versicans; D003165:Complement System Proteins |
Increased neuropeptide Y concentrations in specific hypothalamic regions of lactating rats: possible relationship to hyperphagia and adaptive changes in energy balance. | Lactation is accompanied by hyperphagia and a reduction in brown adipose tissue (BAT) thermogenesis, which are unexplained. Neuropeptide Y (NPY) powerfully stimulates feeding and inhibits BAT thermogenesis when injected into the paraventricular nucleus and other specific regions of the rat hypothalamus. We have tested ... | 10.1016/0196-9781(94)90174-0 | 8,015,984 | D000222:Adaptation, Physiological; D000818:Animals; D001835:Body Weight; D004734:Energy Metabolism; D005260:Female; D006963:Hyperphagia; D007031:Hypothalamus; D007774:Lactation; D009478:Neuropeptide Y; D051381:Rats; D017208:Rats, Wistar | Peptides | 1,994 | D009478:Neuropeptide Y |
The potential role for ultrafast cardiac computed tomography in patients with stroke. | We studied 40 patients with stroke of potential cardioembolic origin by cardiac ultrafast computed tomography and two-dimensional echocardiography. Cardiac ultrafast computed tomography was more sensitive (positive in eight of 14 instances) than two-dimensional echocardiography (positive in two of 14 instances) for the... | 10.1161/01.str.20.4.465 | 2,929,025 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis; D009202:Cardiomyopathies; D002561:Cerebrovascular Disorders; D003287:Contrast Media; D003327:Coronary Disease; D003328:Coronary Thrombosis; D004452:Echocardiography; D004562:Electrocardiography; D005069:Evaluation Studies as... | Stroke | 1,989 | D003287:Contrast Media |
Post-pyloric feeding tube placement in critically ill patients: Extending the scope of practice for Australian dietitians. | AIM
To determine whether the placement of a post-pyloric feeding tube (PPFT) can be taught safely and effectively to a critical care dietitian.
METHODS
This is a prospective observational study conducted in an adult intensive care unit (ICU). The intervention consisted of 19 attempts at post-pyloric intubation by the... | 10.1111/1747-0080.12362 | 29,411,494 | D000328:Adult; D000368:Aged; D001315:Australia; D003422:Critical Care; D016638:Critical Illness; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged; D064686:Nutritionists; D017410:Practice Guidelines as Topic; ... | Nutrition & dietetics: the journal of the Dietitians Association of Australia | 2,018 | |
Estrogen Receptors Promote Migration, Invasion and Colony Formation of the Androgen-Independent Prostate Cancer Cells PC-3 Through β-Catenin Pathway. | Prostate cancer is initially dependent on the androgen, gradually evolves into an androgen-independent form of the disease, also known as castration-resistant prostate cancer (CRPC). At this stage, current therapies scantily improve survival of the patient. Androgens and estrogens are involved in normal prostate and pr... | 10.3389/fendo.2020.00184 | 32,328,032 | D000230:Adenocarcinoma; D000728:Androgens; D002465:Cell Movement; D049109:Cell Proliferation; D004958:Estradiol; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D000078722:PC-3 Cells; D011471:Prostatic Neoplasms; D011960:Receptors, Estrogen; D015398:Signal Transduction; D014410:Tumor Stem Cell Assay; D0604... | Frontiers in endocrinology | 2,020 | D000728:Androgens; D011960:Receptors, Estrogen; D051176:beta Catenin; D004958:Estradiol |
National and International Dimensions of Human Immunodeficiency Virus-1 Sequence Clusters in a Northern California Clinical Cohort. | BACKGROUND
Recent advances in high-throughput molecular epidemiology are transforming the analysis of viral infections.
METHODS
Human immunodeficiency virus (HIV)-1 pol sequences from a Northern Californian cohort (NCC) of 4553 antiretroviral-naive individuals sampled between 1998 and 2016 were analyzed together with... | 10.1093/ofid/ofz135 | 31,041,344 | Open forum infectious diseases | 2,019 | ||
Emotions in reading: disgust, empathy and the contextual learning hypothesis. | Emotion effects in reading have typically been investigated by manipulating words' emotional valence and arousal in lexical decision. The standard finding is that valence and arousal can have both facilitatory and inhibitory effects, which is hard to reconcile with current theories of emotion processing in reading. Her... | 10.1016/j.cognition.2012.07.013 | 22,884,243 | D000293:Adolescent; D000328:Adult; D004644:Emotions; D004645:Empathy; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D008960:Models, Psychological; D011581:Psychological Tests; D011932:Reading; D055815:Young Adult | Cognition | 2,012 | |
Cancer treatment during COVID-19 pandemic. | Currently world is fighting with global pandemic of coronavirus disease 2019 (COVID-19). At this time of uncertainty, oncologists are struggling to provide appropriate care to cancer patients. They have to weigh risk and benefit of giving cancer treatment vs chances of getting them infected with COVID-19. As cancer pat... | 10.1007/s12032-020-01382-w | 32,472,216 | D000970:Antineoplastic Agents; D000073640:Betacoronavirus; D016026:Bone Marrow Transplantation; D000086382:COVID-19; D018352:Coronavirus Infections; D006801:Humans; D009369:Neoplasms; D058873:Pandemics; D011024:Pneumonia, Viral; D000086402:SARS-CoV-2; D016896:Treatment Outcome | Medical oncology (Northwood, London, England) | 2,020 | D000970:Antineoplastic Agents |
Guttman scale analysis of longitudinal data: a methodology and drug use applications. | Traditional Guttman scalogram analysis is limited to evaluating item order cross-sectionally. This paper describes a new methodology, Longitudinal Scalogram Analysis (LSA), that is a direct extension of cross-sectional scalogram analysis to longitudinal data. Example applications of the LSA method to drug use data are ... | 10.3109/10826089009068467 | 2,132,717 | D000293:Adolescent; D003430:Cross-Sectional Studies; D006801:Humans; D013287:Illicit Drugs; D008137:Longitudinal Studies; D015233:Models, Statistical; D012649:Self Concept; D019966:Substance-Related Disorders; D013997:Time Factors | The International journal of the addictions | 1,990 | D013287:Illicit Drugs |
PKA and CaMKII mediate PI3K activation in bovine sperm by inhibition of the PKC/PP1 cascade. | To enable fertilization, spermatozoa must undergo several biochemical processes in the female reproductive tract, collectively called capacitation. These processes involve protein kinase A (PKA)-dependent protein tyrosine phosphorylation including phosphatidylinositol-3-kinase (PI3K). It is not known how PKA, a serine/... | 10.1530/REP-13-0560 | 24,398,875 | D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D002417:Cattle; D017868:Cyclic AMP-Dependent Protein Kinases; D004789:Enzyme Activation; D008297:Male; D058539:Phosphatidylinositol 3-Kinase; D010766:Phosphorylation; D011493:Protein Kinase C; D054645:Protein Phosphatase 1; D015398:Signal Tran... | Reproduction (Cambridge, England) | 2,014 | D058539:Phosphatidylinositol 3-Kinase; D019061:src-Family Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D054645:Protein Phosphatase 1 |
The severity of chronic pediatric pain: an epidemiological study. | UNLABELLED
This study was designed to (1) provide information on the prevalence of pediatric pain as well as other pain related characteristics in a sample of schoolchildren, and (2) study the suitability of a system to grade the severity of chronic pain problems among children. Participants in this cross-sectional stu... | 10.1016/j.jpain.2007.10.015 | 18,088,558 | D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain; D010372:Pediatrics; D012720:Severity of Illness Index | The journal of pain | 2,008 | |
In Vitro and In Vivo Models of Non-Alcoholic Fatty Liver Disease: A Critical Appraisal. | Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and metabolic syndrome. Due to the spread of the obesity epidemic, NAFLD is becoming the most common chronic liver disease and one of the princi... | 10.3390/jcm10010036 | 33,374,435 | Journal of clinical medicine | 2,020 | ||
Functional and adaptive significance of primate pads and claws: evidence from New World anthropoids. | This study tests predicted morphoclines in fingertip morphology among four small-bodied (<1 kg) New World monkeys (Saimiri sciureus, Leontopithecus rosalia, Callithrix jacchus, and Saguinus oedipus) in order to test previous functional and adaptive explanations for the evolution of flattened nails, expanded apical pads... | 10.1002/(SICI)1096-8644(199806)106:2<113::AID-AJPA2>3.0.CO;2-R | 9,637,179 | D000222:Adaptation, Physiological; D000818:Animals; D005075:Biological Evolution; D002427:Cebidae; D005260:Female; D005528:Foot; D006724:Hoof and Claw; D008297:Male | American journal of physical anthropology | 1,998 | |
Self-regenerated silk fibroin with controlled crystallinity for the reinforcement of silk. | HYPOTHESIS
Silk artifacts constitute a fundamental cultural and historical heritage, yet they are affected by degradation that alters the secondary structure of fibroin and weakens the mechanical properties of textiles, hindering their conservation. Feasible and compatible consolidants for silk are still widely needed.... | 10.1016/j.jcis.2020.04.114 | 32,417,684 | D001672:Biocompatible Materials; D005349:Fibroins; D012038:Regeneration; D047011:Silk; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength | Journal of colloid and interface science | 2,020 | D001672:Biocompatible Materials; D047011:Silk; D005349:Fibroins |
Macrophage colony formation supported by purified CSF-1 and/or interleukin 3 in serum-free culture: evidence for hierarchical difference in macrophage colony-forming cells. | Using a serum-free culture system, we examined murine macrophage colony formation from bone marrow cells cultured in the presence of purified CSF-1, interleukin 3 (IL 3) or a combination of the two factors. CSF-1 supported macrophage and neutrophil-macrophage colony formation, whereas IL-3 supported the formation of va... | 3,082,388 | D000818:Animals; D001790:Blood Physiological Phenomena; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors; D003470:Culture Media; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil; D006410:Hematopoiesis; D006412:Hematopoietic Stem Ce... | Blood | 1,986 | D003115:Colony-Stimulating Factors; D003470:Culture Media; D004338:Drug Combinations; D007377:Interleukin-3; D008222:Lymphokines; D005472:Fluorouracil | |
Ligand-mediated immunofunctional assay for quantitation of growth hormone-binding protein in human blood. | Human serum contains a high affinity GH-binding protein (GHBP) whose amino-terminal sequence is identical to the extracellular domain of the GH receptor. Current methods that measure GHBP are laborious, require size or charcoal separation of the GH/GHBP complex, and may be influenced by ambient GH concentrations. We ha... | 10.1210/jcem-73-6-1216 | 1,955,503 | D000910:Antibodies, Heterophile; D001774:Blood Chemical Analysis; D002352:Carrier Proteins; D002853:Chromatography, Liquid; D004355:Drug Stability; D013006:Growth Hormone; D006801:Humans; D007158:Immunologic Techniques; D008024:Ligands; D011986:Receptors, Somatotropin; D012680:Sensitivity and Specificity | The Journal of clinical endocrinology and metabolism | 1,991 | D000910:Antibodies, Heterophile; D002352:Carrier Proteins; D008024:Ligands; D011986:Receptors, Somatotropin; D013006:Growth Hormone; C051815:somatotropin-binding protein |
Application of microbiological rapid on-site evaluation in respiratory intensive care units: a retrospective study. | BACKGROUND
To analyze the clinical value of microbiological rapid on-site evaluation (M-ROSE) in the respiratory intensive care unit (RICU) and its impact on the prognosis of critically ill patients.
METHODS
We retrospectively included patients who underwent bedside bronchoalveolar lavage in the RICU of Chinese Peopl... | 10.21037/atm-21-5465 | 35,242,852 | Annals of translational medicine | 2,022 | ||
Do we get better outcomes from early treatment of Class III discrepancies? | Early orthodontic treatment in the mixed dentition aims to simplify definitive treatment in the permanent dentition. In Class III cases, this can be an effective strategy for the management of a local anterior crossbite, using either a removable or simple fixed appliance. For more significant Class III malocclusions, t... | 10.1038/s41415-022-4507-0 | 35,962,090 | D002508:Cephalometry; D003815:Dentists; D003818:Dentition, Mixed; D006801:Humans; D008310:Malocclusion; D008313:Malocclusion, Angle Class III; D008437:Maxilla; D024382:Professional Role | British dental journal | 2,022 | |
Prevalence and Associated Factors of Work-Related Musculoskeletal Disorders Symptoms among Construction Workers: A Cross-Sectional Study in South China. | Statistics showed that work-related musculoskeletal disorders (WMSDs) are the leading cause of productivity loss in the construction industry. This study aimed to investigate the prevalence of WMSDs and associated factors among construction workers. A cross-sectional study was conducted among 380 construction workers i... | 10.3390/ijerph20054653 | 36,901,662 | D006801:Humans; D003430:Cross-Sectional Studies; D015995:Prevalence; D060389:Construction Industry; D009784:Occupational Diseases; D009140:Musculoskeletal Diseases; D012307:Risk Factors; D011795:Surveys and Questionnaires | International journal of environmental research and public health | 2,023 | |
Sudden gains in the treatment of depression in a partial hospitalization program. | OBJECTIVE
This study examines sudden gains (SGs), or rapid improvements in symptoms, among adults in treatment for depression in a partial hospitalization program (PHP). This study identifies the proportion of people who experience SGs in a PHP, when SGs occur in treatment, and the association of SGs with outcomes at t... | 10.1037/a0022973 | 21,381,809 | D000328:Adult; D003631:Day Care, Medical; D003866:Depressive Disorder; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010549:Personal Satisfaction; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome | Journal of consulting and clinical psychology | 2,011 | |
The functions of binge eating scale (FBES): Development and preliminary psychometric validation. | OBJECTIVE
Binge eating within binge-eating disorder (BED) is a behaviour widely understood as a response to dietary restraint and emotion dysregulation. However, qualitative literature suggests that a wider range of functions of binge eating exist, with associations between functions of binge eating and adverse childho... | 10.1016/j.appet.2023.106479 | 36,736,905 | D000328:Adult; D006801:Humans; D056912:Binge-Eating Disorder; D011594:Psychometrics; D015203:Reproducibility of Results; D002032:Bulimia; D001068:Feeding and Eating Disorders | Appetite | 2,023 | |
A rare case of thyroid-like follicular carcinoma of the kidney in a 75-year-old male: Case report and review of the literature. | INTRODUCTION AND SIGNIFICANCE
The presence of thyroid-like follicular carcinoma in the kidney is very rare, There have been few documented cases of this tumor's formation, and there are no specific signs for this tumor's presence and it is often discovered incidentally by chance, and the diagnosis depends mainly on his... | 10.1016/j.ijscr.2023.108719 | 37,660,492 | International journal of surgery case reports | 2,023 | ||
Three-dimensional dental arch and palatal form changes after extraction and nonextraction treatment. Part 2. Palatal volume and height. | The purpose of this study was to investigate the changes in palatal volume and palatal height in patients treated with and without premolar extractions. Records were collected at pretreatment, at bracket removal, at the end of retention, and 5 years out of retention. Stone casts were mounted in a SAM 2 articulator with... | 10.1016/j.ajodo.2003.05.016 | 15,224,063 | D000293:Adolescent; D000328:Adult; D001641:Bicuspid; D002508:Cephalometry; D002648:Child; D003724:Dental Arch; D003766:Dental Occlusion; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008312:Malocclusion, Angle Class II; D003765:Models, Dental; D009971:Orthodontics, Corrective; D010159:Palate... | American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics | 2,004 | |
Cellular senescence in the lung across the age spectrum. | Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines, growth factors, and remodeling proteins (senescence-associated secretory phenotype; SASP) that have autocrine and paracrine effects on the tissue microenvironment. SASP can promote remodeling, inflammation, infectious susceptibili... | 10.1152/ajplung.00424.2018 | 30,785,345 | D000375:Aging; D000818:Animals; D016922:Cellular Senescence; D016207:Cytokines; D006801:Humans; D007249:Inflammation; D008168:Lung; D008171:Lung Diseases | American journal of physiology. Lung cellular and molecular physiology | 2,019 | D016207:Cytokines |
Thermal stability and mechanism of decomposition of emulsion explosives in the presence of pyrite. | The reaction of emulsion explosives (ammonium nitrate) with pyrite was studied using techniques of TG-DTG-DTA. TG-DSC-MS was also used to analyze samples thermal decomposition process. When a mixture of pyrite and emulsion explosives was heated at a constant heating rate of 10K/min from room temperature to 350°C, exoth... | 10.1016/j.jhazmat.2015.07.069 | 26,292,057 | Journal of hazardous materials | 2,015 | ||
Two chondroitin sulfate proteoglycans differentially expressed in the developing chick visual system. | Two monoclonal antibodies, 2B9 and 9BA12, were used to identify and characterize two different chondroitin sulfate proteoglycans (CSPGs) associated with the embryonic chick visual system. Monoclonal antibody 2B9 recognizes a carbohydrate epitope of collagen type IX proteoglycan. Immunohistochemistry showed that collage... | 10.1006/dbio.1995.1057 | 7,883,066 | D000818:Animals; D000911:Antibodies, Monoclonal; D001369:Axons; D001921:Brain; D002642:Chick Embryo; D011508:Chondroitin Sulfate Proteoglycans; D003094:Collagen; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008807:Mice, Inbred BALB C; D009132:Muscles; D012160:Retina | Developmental biology | 1,995 | D000911:Antibodies, Monoclonal; D011508:Chondroitin Sulfate Proteoglycans; D003094:Collagen |
Metal Domain Size Dependent Electrical Transport in Pt-CdSe Hybrid Nanoparticle Monolayers. | Thin films prepared of semiconductor nanoparticles are promising for low-cost electronic applications such as transistors and solar cells. One hurdle for their breakthrough is their notoriously low conductivity. To address this, we precisely decorate CdSe nanoparticles with platinum domains of one to three nanometers i... | 10.1021/acsnano.5b01221 | 26,052,966 | ACS nano | 2,015 | ||
Perineural Invasion Is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma. | OBJECTIVES
Vulvar squamous cell carcinoma (vSCC) is a gynecologic malignancy diagnosed in nearly 4500 women in the United States each year. Current criteria for treatment planning provide inadequate assessment of aggressive vSCC cases, resulting in insufficient use of adjuvant treatments and high rates of vSCC recurren... | 10.1097/PAS.0000000000000422 | 25,786,085 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001457:Anion Exchange Protein 1, Erythrocyte; D017920:Antiporters; D014408:Biomarkers, Tumor; D001706:Biopsy; D002294:Carcinoma, Squamous Cell; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016015:Logistic Models; D008875:Middle Aged; D015999:Mul... | The American journal of surgical pathology | 2,015 | D001457:Anion Exchange Protein 1, Erythrocyte; D017920:Antiporters; D014408:Biomarkers, Tumor; D009418:S100 Proteins; C489237:SLC4A3 protein, human |
Congenital dacryocystocele diagnosed by antenatal ultrasonography with spontaneous resolution. | Dacryocystocele is a rare benign facial abnormality of the nasolacrimal system, which may be detected at the antenatal workup during the third trimester of pregnancy. Ultrasound is the method of choice for this examination. However, magnetic resonance imaging may also be used in selected cases. Dacryocystocele is mostl... | 10.5935/0004-2749.20200055 | 32,756,791 | D003560:Cysts; D005260:Female; D006801:Humans; D007767:Lacrimal Duct Obstruction; D008279:Magnetic Resonance Imaging; D009301:Nasolacrimal Duct; D011247:Pregnancy; D016216:Ultrasonography, Prenatal | Arquivos brasileiros de oftalmologia | 2,020 | |
Specific Reactions of RSNO, HSNO, and HNO and Their Applications in the Design of Fluorescent Probes. | Nitric oxide (NO)-derived species play essential roles in regulating cellular responses. Among these species, S-nitrosothiols (including RSNO and HSNO) and nitroxyl (HNO) are especially interesting. Owing to their high reactivity and short survival time, the detection of these molecules in biological settings can be ch... | 10.1002/chem.202001885 | 32,433,809 | D005456:Fluorescent Dyes; D009569:Nitric Oxide; D009589:Nitrogen Oxides | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,020 | D005456:Fluorescent Dyes; D009589:Nitrogen Oxides; D009569:Nitric Oxide; C039900:nitroxyl |
Retrospective comparison of laparoscopic versus open radical hysterectomy after neoadjuvant chemotherapy for locally advanced cervical cancer. | OBJECTIVE
To compare outcomes after laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) for locally advanced cervical cancer (LACC)after neoadjuvant chemotherapy (NACT).
METHODS
In a retrospective study, data were analyzed from patients with FIGO stage IB2-IIB cervical cancer who underwen... | 26,434,669 | D000328:Adult; D016063:Blood Loss, Surgical; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007044:Hysterectomy; D010535:Laparoscopy; D008198:Lymph Nodes; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D061646:Operative Time; D012189:Ret... | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics | 2,016 | ||
[Prophylaxis for deep vein thrombosis with low molecular weight heparin following hip and knee surgery]. | OBJECTIVE
To evaluate the efficacy and safety of low molecular weight heparin(LMWH) in prophylaxis of postoperative deep vein thrombosis (DVT) following hip and knee surgery.
METHODS
From April 1997 to October 1998, 46 patients undergoing hip and knee orthopedic procedures were randomized into 2 groups for studying. ... | 12,563,929 | D000328:Adult; D000368:Aged; D000925:Anticoagulants; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D006495:Heparin, Low-Molecular-Weight; D006801:Humans; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D020246:Venous Thrombosis | Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | 2,001 | D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight | |
Laparoscopically assisted ventriculoperitoneal shunt placement in infants with previous multiple abdominal operations. | BACKGROUND
The insertion of a ventriculoperitoneal shunt (VPS) is the treatment of choice in patients with hydrocephalus. However, VPS placement may be difficult in patients with extensive adhesions following prior abdominal interventions. Laparoscopic placement of the abdominal part of the VPS allows controlled adhesi... | 10.1055/s-0029-1202257 | 19,499,491 | D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010535:Laparoscopy; D008297:Male; D000267:Tissue Adhesions; D016896:Treatment Outcome; D017287:Ventriculoperitoneal Shunt | European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie | 2,009 | |
The opposite effects of nitric oxide donor, S-nitrosoglutathione, on myocardial ischaemia/reperfusion injury in diabetic and non-diabetic mice. | Nitric oxide is a potent anti-apoptotic and cardioprotective molecule in healthy animals. However, recent study demonstrates that overexpression of eNOS exacerbates the liver injury in diabetic animals. whether diabetes may also alter NO's biologic activity in ischaemic/reperfused heart remains unknown. The present exp... | 10.1111/1440-1681.12781 | 28,500,760 | D000818:Animals; D003921:Diabetes Mellitus, Experimental; D004347:Drug Interactions; D051379:Mice; D008810:Mice, Inbred C57BL; D015428:Myocardial Reperfusion Injury; D009569:Nitric Oxide; D020030:Nitric Oxide Donors; D009942:Organometallic Compounds; D026422:S-Nitrosoglutathione; D012459:Salicylates | Clinical and experimental pharmacology & physiology | 2,017 | C433928:EUK-134; D020030:Nitric Oxide Donors; D009942:Organometallic Compounds; D012459:Salicylates; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione |
Twentieth-century emergence of antimicrobial resistant human- and bovine-associated Salmonella enterica serotype Typhimurium lineages in New York State. | Salmonella enterica serotype Typhimurium (S. Typhimurium) boasts a broad host range and can be transmitted between livestock and humans. While members of this serotype can acquire resistance to antimicrobials, the temporal dynamics of this acquisition is not well understood. Using New York State (NYS) and its dairy cat... | 10.1038/s41598-020-71344-9 | 32,879,348 | D000818:Animals; D000900:Anti-Bacterial Agents; D002417:Cattle; D002511:Cephalosporins; D024901:Drug Resistance, Multiple, Bacterial; D019143:Evolution, Molecular; D006801:Humans; D009518:New York; D010802:Phylogeny; D012486:Salmonella typhimurium; D065288:Serogroup | Scientific reports | 2,020 | D000900:Anti-Bacterial Agents; D002511:Cephalosporins |
[The influence of workplace violence on burnout sense in clinical nurses]. | Objective: To explore the influence mechanism of intrusive thoughts and ego depletion between effects of workplace violence on burnout sense in clinical nurses. Methods: In May 2019, 10 cities in Henan Province and Fujian Province were selected as sampling cities by the method of grabbing random balls. Using the strati... | 10.3760/cma.j.cn121094-20201027-00599 | 35,255,562 | D000328:Adult; D000368:Aged; D002055:Burnout, Professional; D003430:Cross-Sectional Studies; D006801:Humans; D007588:Job Satisfaction; D009726:Nurses; D010563:Personnel Turnover; D011795:Surveys and Questionnaires; D017132:Workplace; D064450:Workplace Violence | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases | 2,022 | |
Tongue worm (subclass: Pentastomida) infection and treatment in two domesticated reptiles - A case report. | Tongue worms (Subclass: Pentastomida) are endoparasites found in carnivorous reptiles, fish, amphibians, birds, and mammals. Several pentastomids cause pentastomiasis, a zoonotic disease. We encountered tongue worm infection in two reptiles imported into Japan: a Wahlberg's velvet gecko (Homopholis wahlbergii) bred in ... | 10.1016/j.parint.2022.102617 | 35,777,656 | D000663:Amphibians; D000818:Animals; D017821:Boidae; D006801:Humans; D008116:Lizards; D008322:Mammals; D057078:Pentastomida; D015047:Zoonoses | Parasitology international | 2,022 | |
Fluorine in the UK environment. | Relatively low concentrations of fluorine in drinking water (≤ 1 mg F/l) have been shown to significantly reduce the degree of dental caries in children and fluorine would also appear to have a beneficial effect on bone formation in both humans and farm animals. However, it is apparent that elevated levels of fluorine ... | 10.1007/BF01758677 | 24,213,649 | Environmental geochemistry and health | 1,988 | ||
The biosynthesis of membrane-bound M13 coat protein. Energetics and assembly intermediates. | The major coat protein of bacteriophage M13 spans the plasma membrane of infected cells prior to its assembly into extruding virus. It is initially made as a precursor, termed procoat, with a 23-residue leader sequence at its NH2 terminus. Procoat is found bound to the inner surface of the plasma membrane. The electric... | 7,042,715 | D001426:Bacterial Proteins; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone; D002462:Cell Membrane; D003090:Coliphages; D004926:Escherichia coli; D007700:Kinetics; D008565:Membrane Proteins; D009154:Mutation; D011498:Protein Precursors; D014764:Viral Proteins | The Journal of biological chemistry | 1,982 | D001426:Bacterial Proteins; D008565:Membrane Proteins; D011498:Protein Precursors; D014764:Viral Proteins; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone | |
Forskolin and myocardial function in the normal, ischemic and reperfused rat heart. | Forskolin increases intracellular cyclic AMP content by direct stimulation of adenylate-cyclase independently of the beta receptor. Studies have been carried out in two different types of isolated rat heart preparation to compare the cardiovascular effects of forskolin and isoprenaline. The inotropic and chronotropic p... | 3,021,303 | D000818:Animals; D005576:Colforsin; D003326:Coronary Circulation; D000242:Cyclic AMP; D004305:Dose-Response Relationship, Drug; D006321:Heart; D006324:Heart Arrest, Induced; D006339:Heart Rate; D007545:Isoproterenol; D008297:Male; D009200:Myocardial Contraction; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Str... | The Canadian journal of cardiology | 1,986 | D005576:Colforsin; D000242:Cyclic AMP; D007545:Isoproterenol | |
Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. | The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, we... | 9,028,970 | D000595:Amino Acid Sequence; D000818:Animals; D006086:Graft vs Host Disease; D006183:H-2 Antigens; D006801:Humans; D007166:Immunosuppressive Agents; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D00... | Blood | 1,997 | D006183:H-2 Antigens; D007166:Immunosuppressive Agents; D010446:Peptide Fragments; D019408:Platelet Endothelial Cell Adhesion Molecule-1 | |
The relationship of the sympathetic nervous system and the renin-angiotensin system in congestive heart failure. | Congestive heart failure is a complex clinical syndrome characterized by circulatory and metabolic abnormalities. It has been apparent for more than 25 years that the sympathetic nervous system and the renin-angiotensin-aldosterone system are markedly activated in the late stages of heart failure. These two systems int... | 10.1016/0002-8703(89)90291-3 | 2,570,521 | D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D000804:Angiotensin II; D000806:Angiotensin-Converting Enzyme Inhibitors; D006333:Heart Failure; D006801:Humans; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; D012084:Renin-Angiotensin System; D013564:Sympathetic Nervous System; D0173... | American heart journal | 1,989 | D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; D000804:Angiotensin II; D017307:Xamoterol |
PRP8 intein in Ajellomycetaceae family pathogens: sequence analysis, splicing evaluation and homing endonuclease activity. | Inteins are intervening sequences that are transcribed and translated with flanking host protein sequences and then self-excised by protein splicing. Bi-functional inteins also contain a homing endonuclease responsible for their genetic mobility. The PRP8 intein, the most widespread among fungi, occurs in important pat... | 10.1016/j.fgb.2010.07.010 | 20,682,355 | D000595:Amino Acid Sequence; D001758:Blastomyces; D002912:Chrysosporium; D016000:Cluster Analysis; D004720:Endonucleases; D004926:Escherichia coli; D005656:Fungal Proteins; D047668:Inteins; D008969:Molecular Sequence Data; D010802:Phylogeny; D019154:Protein Splicing; D016415:Sequence Alignment; D017421:Sequence Analysi... | Fungal genetics and biology : FG & B | 2,011 | D005656:Fungal Proteins; D004720:Endonucleases |
[Biological markers for early diagnosis of Alzheimer's disease]. | Dementia is a declined state of cognitive functions which impair daily and social life mainly caused by progressive neurodegenerative disease, such as Alzheimer's disease(AD). The present study showed that about 15% of patients in Japan aged over 65 have dementia. The important point regarding the diagnosis of dementia... | 24,800,502 | D000375:Aging; D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides; D015415:Biomarkers; D018450:Disease Progression; D042241:Early Diagnosis; D006801:Humans | Rinsho byori. The Japanese journal of clinical pathology | 2,014 | D016229:Amyloid beta-Peptides; D015415:Biomarkers | |
Combined intervention for controlling unwanted homosexual behavior: an extended follow-up. | Of 49 patients who were able via previous therapy to control their sexual arousal in the presence of homosexual stimuli, 31 (63%) were contracted for follow-up. The average period since the end of treatment was 4 years. Nineteen subjects (61%) have remained exclusively heterosexual, whereas nine (29%) have had homosexu... | 952,610 | D001521:Behavior Therapy; D001945:Breathing Exercises; D004565:Electroconvulsive Therapy; D005500:Follow-Up Studies; D006716:Homosexuality; D006801:Humans; D008297:Male; D008393:Marriage; D012725:Sexual Behavior | Archives of sexual behavior | 1,976 | ||
Structure-activity studies with histamine H3-receptor ligands. | Starting from thioperamide, the first potent and selective H3-receptor histamine antagonist, analogues have been synthesised and tested in vitro on rat cerebral cortex to explore structure-activity relationships. The aim has been to design compounds which do not possess the thiourea group of thioperamide and which may ... | 7,674,117 | D000818:Animals; D017442:Histamine Agonists; D006633:Histamine Antagonists; D006801:Humans; D013329:Structure-Activity Relationship | Journal de pharmacie de Belgique | 1,995 | D017442:Histamine Agonists; D006633:Histamine Antagonists | |
Antifibrinolytic therapy: evidence, bias, confounding (and politics!). | Cardiac surgery can be complicated by postoperative bleeding and a need for blood transfusion and surgical reexploration. Anti-fibrinolytic drugs such as aprotinin and tranexamic acid may reduce bleeding risks but could possibly increase thrombotic complications. Aprotinin, in particular, has recently been implicated i... | 18,293,827 | D000933:Antifibrinolytic Agents; D007611:Aprotinin; D015982:Bias; D002315:Cardiopulmonary Bypass; D015986:Confounding Factors, Epidemiologic; D019317:Evidence-Based Medicine; D006801:Humans; D013903:Thoracic Surgery; D013923:Thromboembolism; D014148:Tranexamic Acid | The journal of extra-corporeal technology | 2,007 | D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid; D007611:Aprotinin | |
Determination of veterinary pharmaceuticals in poultry litter and soil by methanol extraction and liquid chromatography-tandem mass spectrometry. | Pharmaceuticals are emerging contaminants with potential risks to the environment and human health. A liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed for determination of the antimicrobials virginiamycin, monensin, salinomycin, narasin and nicarbazin in poultry litter and soil. This metho... | 10.1080/03601230903163863 | 20,183,082 | D000818:Animals; D005591:Chemical Fractionation; D002851:Chromatography, High Pressure Liquid; D005898:Glass; D006801:Humans; D057230:Limit of Detection; D008372:Manure; D000432:Methanol; D011200:Poultry; D012987:Soil; D053719:Tandem Mass Spectrometry; D019155:Veterinary Drugs | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes | 2,009 | D008372:Manure; D012987:Soil; D019155:Veterinary Drugs; C009753:fiberglass; D000432:Methanol |
[Therapy of cancer pain--a comprehensive therapy concept]. | A comprehensive conception for cancer pain treatment is presented. The medical analgesic drug therapy representing the main point of this conception is applied as a three steps analgesic ladder as recommend by the WHO. This kind of therapy enables an individual adaptation resp. increase of the analgesic intensity by th... | 2,466,450 | D000700:Analgesics; D006801:Humans; D009369:Neoplasms; D010146:Pain; D010166:Palliative Care | Archiv fur Geschwulstforschung | 1,989 | D000700:Analgesics | |
A 3D k-space Fourier encoding and reconstruction framework for simultaneous multi-slab acquisition. | PURPOSE
To propose a novel 3D k-space Fourier encoding and reconstruction framework for simultaneous multi-slab (SMSlab) acquisition and demonstrate its efficacy in high-resolution imaging.
METHODS
First, it is illustrated in theory how the inter-slab gap interferes with the formation of the SMSlab 3D k-space. Then, ... | 10.1002/mrm.27793 | 31,045,283 | D000465:Algorithms; D001921:Brain; D005583:Fourier Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging | Magnetic resonance in medicine | 2,019 | |
Resuscitation, isolation and immobilization of bacterial species for efficient textile wastewater treatment: A critical review and update. | Given highly complex and recalcitrant nature of synthetic dyes, textile wastewater poses a serious challenge on surrounding environments. Until now, biological treatment of textile wastewater using efficient bacterial species is still considered as an environmentally friendly and cost-effective approach. The advances i... | 10.1016/j.scitotenv.2020.139034 | 32,416,505 | D001419:Bacteria; D004396:Coloring Agents; D053038:Quorum Sensing; D013784:Textiles; D062065:Wastewater | The Science of the total environment | 2,020 | D004396:Coloring Agents; D062065:Waste Water |
How to start or change a daily insulin regimen without a specialist in diabetes. Effectiveness and RAND assessment of practical schemes for in-hospital or hospital-based home care services use. | When the diabetic patient is hospitalised or assisted by a hospital-based home care service, as a rule he/she is not cared for by a diabetologist all day long. The aim of the present work was to perform a RAND assessment of practical schemes to start or change a daily insulin regimen without a diabetologist. We created... | 10.1007/s00592-006-0206-6 | 16,710,646 | D001786:Blood Glucose; D003920:Diabetes Mellitus; D004334:Drug Administration Schedule; D006699:Home Care Services; D006801:Humans; D006943:Hyperglycemia; D007004:Hypoglycemic Agents; D007328:Insulin; D011336:Probability | Acta diabetologica | 2,006 | D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin |
Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response. | Acute graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in patients undergoing allogeneic bone marrow transplantation (BMT) for the treatment of leukemia and other immunogenetic disorders. The use of tolerogenic dendritic cells (DCs) that induce the generation/activation of regulatory T (Tr) ... | 10.1182/blood-2005-11-4495 | 16,418,327 | D000208:Acute Disease; D000818:Animals; D016026:Bone Marrow Transplantation; D003713:Dendritic Cells; D005260:Female; D006086:Graft vs Host Disease; D020350:Graft vs Tumor Effect; D007108:Immune Tolerance; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D050378:T-Lymphoc... | Blood | 2,006 | D014660:Vasoactive Intestinal Peptide |
[Diagnostic and therapeutic angiography in the evaluation and treatment of glomus jugulare tumors. Apropos of 32 cases]. | This report is based on 32 cases of jugular paraganglioma treated by embolization, of which 7 had cervical and/or intrajugular extensions, five a giant extension involving mainly the carotid canal and one excretory activity. Aims and methods of diagnostic and therapeutic angiography are envisaged as well as results in ... | 3,003,609 | D000792:Angiography; D002342:Carotid Artery, External; D002343:Carotid Artery, Internal; D003250:Constriction; D004621:Embolization, Therapeutic; D005069:Evaluation Studies as Topic; D005925:Glomus Jugulare Tumor; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D010236:Paraganglioma, ... | Neuro-Chirurgie | 1,985 | ||
Comparison of soxhlet and microwave-assisted extractions for the determination of fenitrothion residues in beans. | White and black "niebe" beans [Vigna unguiculata (L.) Walp] from Senegal were treated with fenitrothion (O,O-dimethyl O-4-nitro-m-tolyl phosphorothioate), and the residues were determined by high-performance liquid chromatography (HPLC) and electron capture gas chromatography (EC-GC). Fenitrothion residues from the bea... | 10.1021/jf011469w | 12,009,987 | D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D007887:Fabaceae; D005278:Fenitrothion; D005506:Food Contamination; D007306:Insecticides; D008872:Microwaves; D010573:Pesticide Residues; D012675:Senegal | Journal of agricultural and food chemistry | 2,002 | D007306:Insecticides; D010573:Pesticide Residues; D005278:Fenitrothion |
[Molecular cloning of a novel low-molecular-weight glutenin subunit gene from wheat variety "Chuanmai 42"]. | Using PCR-amplification method, the coding sequences of a novel low-molecular-weight glutenin (LMW-GS) gene, LMWCM42-1, was isolated from the genomic DNA of wheat (Triticum aestivum L.) variety 'Chuanmai 42'. The full coding region of this gene consisted of 846 nucleotides, and encoded a protein with 281 amino acids. L... | 16,469,718 | D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D005983:Glutens; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014908:Triticum | Yi chuan = Hereditas | 2,006 | D005983:Glutens; C037302:glutenin | |
[A case of sarcoidosis associated with Sjögren's syndrome]. | A 49-year-old woman, who has had a past history of Raynaud's phenomenon since 1981, dry mouth since 1987 and dry eyes since 1990, was admitted to our hospital complaining of general fatigue, bilateral gonalgia, and shortness of breath in April 1991. Physical examinations revealed bilateral parotid gland enlargement and... | 1,482,299 | D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007668:Kidney; D007669:Kidney Calculi; D007674:Kidney Diseases; D008875:Middle Aged; D012507:Sarcoidosis; D012859:Sjogren's Syndrome; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography | Arerugi = [Allergy] | 1,992 | ||
Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells. | BACKGROUND AND AIMS
Curcumin is a hydrophobic polyphenol derived from turmeric, a traditional Indian spice. Curcumin exhibits various biological functions, but its clinical application is limited due to its poor absorbability after oral administration. A newly developed nanoparticle curcumin shows improved absorbabilit... | 10.1371/journal.pone.0185999 | 28,985,227 | D000818:Animals; D003092:Colitis; D003474:Curcumin; D016207:Cytokines; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D000069196:Gastrointestinal Microbiome; D007413:Intestinal Mucosa; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D050378:T-Lymphocytes, Regulatory | PloS one | 2,017 | D016207:Cytokines; D016264:Dextran Sulfate; D003474:Curcumin |
Unusual metastases from a malignant melanoma. A case report. | An unusual case of malignant melanoma metastatic to the lung and to the ovaries occurred 9 and 11 years, respectively, after the initial, extragenital diagnosis. The primary lesion invaded to Clark's level IV with a thickness of greater than 4 mm, normally grave prognostic indicators. A metastatic lung nodule seen radi... | 1,774,737 | D000328:Adult; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008545:Melanoma; D010051:Ovarian Neoplasms; D010053:Ovary; D012878:Skin Neoplasms | The Journal of reproductive medicine | 1,991 | ||
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. | Mutations of the mitochondrial genome (mtDNA) underlie a substantial portion of mitochondrial disease burden. These disorders are currently incurable and effectively untreatable, with heterogeneous penetrance, presentation and prognosis. To address the lack of effective treatment for these disorders, we exploited a rec... | 10.1038/s41591-018-0165-9 | 30,250,142 | D000818:Animals; D004272:DNA, Mitochondrial; D000229:Dependovirus; D004195:Disease Models, Animal; D000072669:Gene Editing; D006801:Humans; D051379:Mice; D008929:Mitochondria, Heart; D028361:Mitochondrial Diseases; D009154:Mutation; D011379:Prognosis; D012343:RNA, Transfer; D000075804:Zinc Finger Nucleases | Nature medicine | 2,018 | D004272:DNA, Mitochondrial; D012343:RNA, Transfer; D000075804:Zinc Finger Nucleases |
Spinal epidural hematoma after stretch exercise: a case report. | Spinal epidural hematoma (SEH) is a rare but serious condition. Common causes of SEH include spinal fracture, spinal trauma, and invasive spinal procedures such as lumbar puncture, epidural anesthesia, or myelography. A few previous reports have suggested that SEH could be caused by minor triggers such as spinal manipu... | 10.1016/j.ajem.2008.11.011 | 19,683,136 | D018450:Disease Progression; D046748:Hematoma, Epidural, Spinal; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D052580:Muscle Stretching Exercises; D014057:Tomography, X-Ray Computed | The American journal of emergency medicine | 2,009 | |
Comparison of the measured and predicted response of the Earth Radiation Budget Experiment active cavity radiometer during solar observations. | The Earth Radiation Budget Experiment consists of an array of radiometric instruments placed in earth orbit by the National Aeronautics and Space Administration to monitor the longwave and visible components of the earth's radiation budget. Presented is a dynamic electrothermal model of the active cavity radiometer use... | 10.1364/AO.28.001327 | 20,548,660 | Applied optics | 1,989 | ||
Antimicrobial properties of olive oil phenolic compounds and their regenerative capacity towards fibroblast cells. | Some micronutrients of vegetable origin are considered potentially useful as wound-healing agents because they can increase fibroblast proliferation and differentiation.
THE AIM OF THIS STUDY
was to evaluate the regenerative effects of selected olive oil phenolic compounds on cultured human fibroblasts and explore th... | 10.1016/j.jtv.2021.03.003 | 33,810,929 | D000890:Anti-Infective Agents; D049109:Cell Proliferation; D005347:Fibroblasts; D006801:Humans; D000069463:Olive Oil; D012038:Regeneration | Journal of tissue viability | 2,021 | D000890:Anti-Infective Agents; D000069463:Olive Oil |
Addressing food insecurity in the United States: the role of policy, systems changes, and environmental supports. | This commentary provides a brief overview of the historical, contemporary, and potential future approaches for using policy, systems changes, and environmental supports (PSE) to address food insecurity in the United States. We reflect on and integrate where possible the findings put forth in the other 16 papers include... | 10.1093/tbm/ibz131 | 31,504,976 | D000288:Administrative Personnel; D003299:Cooperative Behavior; D004032:Diet; D005523:Food Supply; D006801:Humans; D006815:Hunger; D009765:Obesity; D011203:Poverty; D011640:Public Policy; D014481:United States | Translational behavioral medicine | 2,019 | |
Optimizing staff scheduling by Monte-Carlo simulation. | DOCS is a computer program which generates the staff schedule. An accounting framework is combined with an optimization technique that searches for a schedule in which all accounts are simultaneously in balance. The search is accomplished using a Monte-Carlo process which shuffles staff within the schedule. The shuffli... | 1,482,957 | D000465:Algorithms; D005069:Evaluation Studies as Topic; D009010:Monte Carlo Method; D010562:Personnel Staffing and Scheduling Information Systems; D012984:Software | Proceedings. Symposium on Computer Applications in Medical Care | 1,992 | ||
The dynamics of high Rydberg states in the presence of time-dependent inhomogeneous fields | This paper presents calculations of the evolution of an optically prepared Rydberg wavepacket in the presence of time-dependent inhomogeneous electric fields and the results have relevance to the stabilization of Rydberg states as appropriate to ZEKE spectroscopy. The field is considered to arise from the combination o... | 10.1039/a909489j | 11,040,514 | Faraday discussions | 2,000 | ||
[Diaminodiphenyl sulfone therapy for refractory idiopathic thrombocytopenic purpura--long-term effectiveness and possible mechanisms]. | Eight patients with idiopathic thrombocytopenic purpura (ITP) refractory to corticosteroids were given oral diaminodiphenyl sulfone (DDS) (75 mg to 150 mg/day). Responses to DDS were observed in 5 patients, and their platelet counts significantly increased to more than 10 x 10(4)/microliter. The duration of treatment r... | 10,565,223 | D000284:Administration, Oral; D000328:Adult; D003622:Dapsone; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007917:Leprostatic Agents; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic | [Rinsho ketsueki] The Japanese journal of clinical hematology | 1,999 | D007917:Leprostatic Agents; D003622:Dapsone | |
Pathogenicity and transmissibility of a novel respirovirus isolated from a Malayan pangolin. | The identification of SARS-CoV-2-like viruses in Malayan pangolins (Manis javanica) has focused attention on these endangered animals and the viruses they carry. We successfully isolated a novel respirovirus from the lungs of a dead Malayan pangolin. Similar to murine respirovirus, the full-length genome of this novel ... | 10.1099/jgv.0.001586 | 33,843,572 | D000818:Animals; D056727:Endangered Species; D005260:Female; D016679:Genome, Viral; D051379:Mice; D000086642:Pangolins; D010802:Phylogeny; D018108:Respirovirus; D010253:Respirovirus Infections | The Journal of general virology | 2,021 | |
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine. | Microglial function declines during aging. The interaction of microglia with the gut microbiota has been well characterized during development and adulthood but not in aging. Here, we compared microglial transcriptomes from young-adult and aged mice housed under germ-free and specific pathogen-free conditions and found... | 10.1038/s41593-022-01027-3 | 35,241,804 | D000818:Animals; D000069196:Gastrointestinal Microbiome; D008239:Lysine; D051379:Mice; D017628:Microglia; D018384:Oxidative Stress | Nature neuroscience | 2,022 | C048496:N(6)-carboxymethyllysine; D008239:Lysine |
Phenological advance in the South African Namaqualand Daisy First and Peak Bloom: 1935-2018. | The annual Namaqualand daisy flowering spectacle is a world-renowned environmental event. Using documentary sources, including newspaper archives from The Rand Daily Mail, Volksblad and Die Burger and social media records from Flickr and iNaturalist, the first long-term phenological dataset spanning 1935-2018 was compi... | 10.1007/s00484-021-02229-3 | 34,994,844 | D057231:Climate Change; D035264:Flowers; D006801:Humans; D012621:Seasons; D013019:South Africa; D013696:Temperature | International journal of biometeorology | 2,022 | |
Streptococcus mutans adherence to conventional and self-ligating brackets: an in vitro study. | INTRODUCTION
Although self-ligating brackets presumably provide better hygiene conditions, no consensus has been reached so far.
OBJECTIVE
Therefore, the objective of this study was to evaluate, in an in vitro experimental design, the adherence of Streptococcus mutans (SM) in self-ligating and conventional brackets o... | 10.1590/2177-6709.26.6.e212019.oar | 34,932,711 | D001422:Bacterial Adhesion; D016382:Orthodontic Appliance Design; D016910:Orthodontic Brackets; D009969:Orthodontic Wires; D012107:Research Design; D013295:Streptococcus mutans | Dental press journal of orthodontics | 2,021 | |
Differential cytokine responses of CD4+ and CD8+ T cells in response to bovine viral diarrhoea virus in cattle. | Virus-specific T cell responses were measured in cattle seropositive for bovine viral diarrhoea virus (BVDV) and compared with those from BVDV-seronegative animals. CD4+ and CD8+ T cells were purified and co-cultured in vitro with autologous, BVDV-infected monocytes over a time-course to assess the kinetics of the prol... | 10.1099/0022-1317-80-7-1673 | 10,423,135 | D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D002417:Cattle; D018920:Coculture Techniques; D016207:Cytokines; D001908:Diarrhea Viruses, Bovine Viral; D005260:Female; D008297:Male; D009000:Monocytes | The Journal of general virology | 1,999 | D016207:Cytokines |
Successful immunization against experimental allergic encephalomyelitis with myelin basic protein-sensitized allogeneic lymphocytes. | Prevention and suppression of experimental allergic encephalomyelitis were demonstrated in rats, guinea pigs, and rabbits immunized with allogeneic, but not with syngeneic lymphocytes from susceptible donors sensitized to myelin basic protein (MBP). Donor lymphnode, splenic, or peripheral blood lymphocytes were effecti... | 10.1007/BF00963886 | 6,168,929 | D000818:Animals; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007114:Immunization; D007074:Immunoglobulin G; D008214:Lymphocytes; D004676:Myelin Basic Protein; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D0... | Neurochemical research | 1,981 | D007074:Immunoglobulin G; D004676:Myelin Basic Protein |
Acute porphyria presenting as epilepsia partialis continua. | PURPOSE
The porphyrias are a defect in the biosynthesis of heme which can be associated with different neurological symptoms during acute attacks such as peripheral neuropathy, mental disturbance and seizures. So far, there have only been a few case reports of status epilepticus, none of which were of epilepsia partial... | 10.1159/000353279 | 23,898,283 | Case reports in neurology | 2,013 | ||
Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins. | When experimental hepatitis was induced by administrating rats with hepatotoxins such as CCl4 and D-galactosamine, HGF mRNA increased dramatically in the injured liver. The increase of HGF mRNA was time- and dose-dependent. At 5 hr after CCl4-treatment, HGF mRNA was remarkably increased; it reached the maximum level at... | 10.1016/0006-291x(89)92733-2 | 2,692,563 | D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D015342:DNA Probes; D005688:Galactosamine; D015850:Interleukin-6; D007700:Kinetics; D008099:Liver; D008115:Liver Regeneration; D009693:Nucleic Acid Hybridization; D011506:Proteins; D012333:RNA, Messenger; D051381:Rats | Biochemical and biophysical research communications | 1,989 | D015342:DNA Probes; D015850:Interleukin-6; D011506:Proteins; D012333:RNA, Messenger; D005688:Galactosamine; D002251:Carbon Tetrachloride |
Identification of target and pathway of aspirin combined with Lipitor treatment in prostate cancer through integrated bioinformatics analysis. | PURPOSE
Our previous studies have confirmed that aspirin combined with Lipitor inhibited the development of prostate cancer (PCa), but the mechanisms need to be comprehensively expounded. The study aims to screen out the hub genes of combination therapy and to explore their association with the pathogenesis and prognos... | 10.1016/j.taap.2022.116169 | 35,926,565 | D001241:Aspirin; D000069059:Atorvastatin; D018797:Cell Cycle Proteins; D019295:Computational Biology; D019915:DNA Primase; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D019869:Phosphatidylinositol 3-Kinases; D011471:Prostatic Neoplasms; D017346:Protein Serine-Threonine Kinases | Toxicology and applied pharmacology | 2,022 | D018797:Cell Cycle Proteins; D000069059:Atorvastatin; C068619:CDC7 protein, human; D017346:Protein Serine-Threonine Kinases; D019915:DNA Primase; C000609421:PRIM1 protein, human; D001241:Aspirin |
Assessment of computed tomographic pelvimetry within a selective breech presentation management protocol. | A vital component of selective protocols in term breech presentation management is exclusion of the gravida with borderline pelvic dimensions. Computed tomographic (CT) pelvimetry was employed to evaluate potential candidates for a trial of labor with a breech fetus at term. Thirty-seven of 39 women who underwent labor... | 7,966,034 | D001946:Breech Presentation; D002985:Clinical Protocols; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007744:Obstetric Labor Complications; D010387:Pelvimetry; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D014057:Tomography, X-Ray Computed; D014219:Trial of Labor | The Journal of reproductive medicine | 1,994 | ||
Albumin and the fibrinogen-to-albumin ratio: Biomarkers for the acute phase response following total knee arthroplasty. | PURPOSE
Complications following total knee arthroplasty (TKA) lead to patient morbidity and cost. While acute phase reactants, such as c-reactive protein (CRP) and fibrinogen, have been used to predict complications following TKA, the extent and duration of changes in albumin levels following TKA are unknown. It is hyp... | 10.1371/journal.pone.0247070 | 33,592,030 | D000210:Acute-Phase Reaction; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins; D019645:Arthroplasty, Replacement, Knee; D015415:Biomarkers; D005260:Female; D005340:Fibrinogen; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D012189:Retrospective Studies; D050796:S... | PloS one | 2,021 | D000418:Albumins; D015415:Biomarkers; D050796:STAT3 Transcription Factor; D005340:Fibrinogen |
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