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TRIM65 in White Matter Lesions, Innate Immunity, and Tumor. | Most of the tripartite motif (TRIM) family proteins have E3 ubiquitin ligase activities and also have a variety of functions in cellular processes such as intracellular signal transduction, apoptosis, innate immunity, and carcinogenesis. TRIM65 is a member of the TRIM family. More pieces of evidence have shown a unique... | 10.2174/1874467214666210203211603 | 33,538,683 | D063646:Carcinogenesis; D006801:Humans; D007113:Immunity, Innate; D009369:Neoplasms; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D066127:White Matter | Current molecular pharmacology | 2,021 | D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; C000589384:TRIM65 protein, human |
Incentivising public transport use for physical activity gain: process evaluation of the COVID-19 disrupted trips4health randomised controlled trial. | BACKGROUND
Partnering with a public transport (PT) provider, state government, and local government, the single-blinded randomised controlled trial, trips4health, investigated the impact of PT use incentives on transport-related physical activity (PA) in Tasmania, Australia. The intervention involved 16-weeks of incent... | 10.1186/s12966-022-01394-x | 36,550,500 | D005260:Female; D006801:Humans; D000086382:COVID-19; D009042:Motivation; D015444:Exercise; D015438:Health Behavior; D011795:Surveys and Questionnaires | The international journal of behavioral nutrition and physical activity | 2,022 | |
Role of intraepithelial lymphocytes in mucosal immune responses of mice experimentally infected with Cryptosporidium parvum. | In order to investigate the role of intestinal intraepithelial lymphocytes (IELs) in host defense against Cryptosporidium parvum infection, conventionally bred immunocompetent (ImCT) ICR mice and immunosuppressed (ImSP) littermates were infected orally with 10(6) C. parvum oocysts. Then fecal oocyst excretion, the numb... | 10,219,301 | D000818:Animals; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D003457:Cryptosporidiosis; D016785:Cryptosporidium parvum; D005434:Flow Cytometry; D006801:Humans; D018928:Immunity, Mucosal; D007121:Immunocompetence; D016867:Immunocompromised Host; D007413:Intestinal Mucosa; D018655:Lymphocyte C... | The Journal of parasitology | 1,999 | ||
Tumor promoting effect of phenolphthalein on development of lung tumors induced by N-ethyl-N-nitrosourea in transgenic mice carrying human prototype c-Ha-ras gene. | In order to examine tumor modifying effects of phenolphthalein (PhP), female transgenic mice carrying human prototype c-Ha-ras gene (rasH2 mice) were given a single intraperitoneal injection of 60 mg/kg body weight of N-ethyl-N-nitrosourea (ENU), followed by the diet containing 12,000 ppm PhP for 26-week. Histopatholog... | 10.1292/jvms.64.489 | 12,130,832 | D000230:Adenocarcinoma; D000236:Adenoma; D000818:Animals; D002273:Carcinogens; D005038:Ethylnitrosourea; D005260:Female; D011905:Genes, ras; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms; D051379:Mice; D008822:Mice, Transgenic; D020113:Phenolphthalein; D018809:Proliferating Cell Nuclear Antigen; ... | The Journal of veterinary medical science | 2,002 | D002273:Carcinogens; D018809:Proliferating Cell Nuclear Antigen; D020113:Phenolphthalein; D005038:Ethylnitrosourea |
Changeable effects of coexisting heavy metals on transfer of cadmium from soils to wheat grains. | Cadmium (Cd) and other heavy metals usually coexist in soils. Effects of coexisting heavy metals on the accumulation and transfer of Cd in field soils by wheat remain poorly understood. Here we revealed changeable effects of coexisting Pb, Zn and Cu on the Cd transfer from soils to wheat grains. Soil burdens of Cd were... | 10.1016/j.jhazmat.2021.127182 | 34,537,640 | D002104:Cadmium; D002681:China; D019216:Metals, Heavy; D012987:Soil; D012989:Soil Pollutants; D014908:Triticum | Journal of hazardous materials | 2,022 | D019216:Metals, Heavy; D012987:Soil; D012989:Soil Pollutants; D002104:Cadmium |
Influence of O2 Flow Rate on the Properties of Ga2O3 Growth by RF Magnetron Sputtering. | The influence of the O2 flow rate on the properties of gallium oxide (Ga2O3) by RF magnetron sputtering was studied. X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmittance spectra, and photoluminescence (PL) spectra have been employed to study the Ga2O3 thin films. Wit... | 10.3390/mi14020260 | 36,837,960 | Micromachines | 2,023 | ||
Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study. | Fecal volatile organic compounds (VOC) reflect human and gut microbiota metabolic pathways and their interaction. VOC behold potential as non-invasive preclinical diagnostic biomarkers in various diseases, e.g., necrotizing enterocolitis and late onset sepsis. There is a need for standardization and assessment of the i... | 10.3390/bios10050050 | 32,403,393 | D002585:Cesarean Section; D015331:Cohort Studies; D036861:Delivery, Obstetric; D005243:Feces; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D011446:Prospective Studies; D055549:Volatile Organic Compounds | Biosensors | 2,020 | D055549:Volatile Organic Compounds |
Optically controlled molecular switching of an indolobenzoxazine-type photochromic compound. | Photochromic forward (oxazine ring-opening) and backward (oxazine ring-closing) switching dynamics of an indolobenzoxazine compound were studied by femtosecond pump-repump-probe technique. A UV pulse was used to excite the ring-closed form of the photochromic compound, causing a C-O bond cleavage and the formation of a... | 10.1021/jp505723q | 25,014,554 | The journal of physical chemistry. A | 2,014 | ||
Design and synthesis of some novel hybrid molecules based on 4-thiazolidinone bearing pyridine-pyrazole scaffolds: molecular docking and molecular dynamics simulations of its major constituent onto DNA gyrase inhibition. | Due to multidrug resistance, microbial infections have become significant on a global level. As infections caused by several resistant bacteria and fungi severely harm mankind, scientists have developed new antibiotics to combat these infections. In order to develop novel antimicrobial agents, a series of 4-thiazolidin... | 10.1007/s11030-023-10612-y | 36,750,538 | Molecular diversity | 2,023 | ||
The effect of flaxseed supplementation on sex hormone profile in adults: a systematic review and meta-analysis. | Inconsistent data suggest that flaxseed supplementation may have a role in sex hormones. We aimed to carry out a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating effects of flaxseed supplementation on sex hormone profile. PubMed, Scopus, Embase, Cochrane Library, Web of Science d... | 10.3389/fnut.2023.1222584 | 37,927,501 | Frontiers in nutrition | 2,023 | ||
Neuroprotection in epilepsy. | Neuroprotection following status epilepticus should encompass not only the prevention of neuronal death, but also preservation of neuronal and network function. This is critical because these aims are not necessarily equivalent; prevention of neuronal loss, for example, does not inevitably prevent epileptogenesis. Ther... | 10.1111/j.1528-1167.2007.01354.x | 18,330,004 | D016923:Cell Death; D002540:Cerebral Cortex; D003072:Cognition Disorders; D004827:Epilepsy; D006801:Humans; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; D013226:Status Epilepticus | Epilepsia | 2,007 | D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate |
Relative biological effectiveness (RBE) and distal edge effects of proton radiation on early damage in vivo. | INTRODUCTION
The aim of the present study was to examine the RBE for early damage in an in vivo mouse model, and the effect of the increased linear energy transfer (LET) towards the distal edge of the spread-out Bragg peak (SOBP).
METHOD
The lower part of the right hind limb of CDF1 mice was irradiated with single fr... | 10.1080/0284186X.2017.1351621 | 28,830,292 | D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D018499:Linear Energy Transfer; D051379:Mice; D011522:Protons; D012062:Relative Biological Effectiveness; D012867:Skin | Acta oncologica (Stockholm, Sweden) | 2,017 | D011522:Protons |
Ternidens deminutus Revisited: A Review of Human Infections with the False Hookworm. | Ternidens deminutus, the false hookworm of humans and non-human primates, represents a truly neglected intestinal helminth infection. The similarity of the eggs of this nematode to those of hookworm both presents a diagnostic challenge and a potential confounder in prevalence surveys of soil transmitted helminths (STH)... | 10.3390/tropicalmed4030106 | 31,323,820 | Tropical medicine and infectious disease | 2,019 | ||
Nitric oxide as putative nonadrenergic noncholinergic inhibitory transmitter in the opossum sphincter of Oddi. | The sphincter of Oddi has a typical nonadrenergic noncholinergic inhibitory innervation; however, the transmitter of this inhibition has not been identified. The aim of the present study was to evaluate whether metabolites of the L-arginine--nitric oxide synthase pathway mediate neural inhibition in the sphincter of Od... | 10.1139/y93-077 | 7,902,198 | D000320:Adrenergic Fibers; D000818:Animals; D001120:Arginine; D001285:Atropine; D002799:Cholinergic Fibers; D066298:In Vitro Techniques; D008751:Methylene Blue; D009119:Muscle Contraction; D019331:NG-Nitroarginine Methyl Ester; D018377:Neurotransmitter Agents; D009569:Nitric Oxide; D009893:Opossums; D009803:Sphincter o... | Canadian journal of physiology and pharmacology | 1,993 | D018377:Neurotransmitter Agents; D009569:Nitric Oxide; D001285:Atropine; D001120:Arginine; D008751:Methylene Blue; D019331:NG-Nitroarginine Methyl Ester |
Can the association between hypertension and physical activity be moderated by age? | Objectives
Physical inactivity, hypertension and non-communicable diseases are major public concerns across the globe. To our knowledge, there is a lack of research that has investigated the moderating effect of age on the relationship between hypertension and physical activity in developing countries. This study had t... | 10.1016/j.jtumed.2022.12.016 | 36,852,251 | Journal of Taibah University Medical Sciences | 2,023 | ||
Discriminative Accuracy of Chronic Obstructive Pulmonary Disease Screening Instruments in 3 Low- and Middle-Income Country Settings. | Importance
Most of the global morbidity and mortality in chronic obstructive pulmonary disease (COPD) occurs in low- and middle-income countries (LMICs), with significant economic effects.
Objective
To assess the discriminative accuracy of 3 instruments using questionnaires and peak expiratory flow (PEF) to screen fo... | 10.1001/jama.2021.23065 | 35,015,039 | D000328:Adult; D000402:Airway Obstruction; D003430:Cross-Sectional Studies; D003906:Developing Countries; D005240:Feasibility Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009390:Nepal; D010366:Peak Expiratory Flow Rate; D010568:Peru; D011237:Predictive V... | JAMA | 2,022 | D014028:Tobacco Smoke Pollution |
Estimation of daily mercury intake from seafood in Japanese women: Akita cross-sectional study. | We estimated daily mercury intakes from seafood in 154 mothers residing in several cities and towns in Akita, Japan, to address the relationships between the reference dose (RfD of 0.1 microg/kg body weight per day, derived by US EPA) and daily mercury intakes, combined with hair mercury levels. The frequency and volum... | 10.1620/tjem.200.67 | 12,962,403 | D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D004032:Diet; D015930:Diet Records; D005260:Female; D005506:Food Contamination; D006197:Hair; D006801:Humans; D007564:Japan; D018811:Maternal Exposure; D008767:Methylmercury Compounds; D008875:Middle Aged; D012016:Reference Values; D017747:Seafood; D011795:... | The Tohoku journal of experimental medicine | 2,003 | D008767:Methylmercury Compounds |
Heparin-platinum nanozymes with enhanced oxidase-like activity for the colorimetric sensing of isoniazid. | In this study, a colorimetric sensing assay of isoniazid based on excellent oxidase-like activity of heparin sodium stabilized platinum nanoparticles (HS-PtNPs) has been demonstrated. The newly prepared HS-PtNPs exhibit a great dispersion with an average size distribution of 4.8 ± 0.6 nm, and maintain more than 90% cat... | 10.1016/j.talanta.2019.120707 | 32,070,586 | D000995:Antitubercular Agents; D001560:Benzidines; D003124:Colorimetry; D006493:Heparin; D007538:Isoniazid; D053768:Metal Nanoparticles; D010088:Oxidoreductases; D010984:Platinum; D013607:Tablets | Talanta | 2,020 | D000995:Antitubercular Agents; D001560:Benzidines; D013607:Tablets; C021758:3,3',5,5'-tetramethylbenzidine; D010984:Platinum; D006493:Heparin; D010088:Oxidoreductases; D007538:Isoniazid |
Epitope-Based Specific Antibody Modifications. | Modified antibodies have essential roles in analytic, diagnostic, and therapeutic uses, and thus, these antibodies are required to have optimal physical and biological properties. Consequently, the development of methods for site-selective antibody modification is crucial. Herein, we used epitope-based affinity labelin... | 10.1021/acs.bioconjchem.3c00340 | 37,861,691 | D000939:Epitopes; D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D000915:Antibody Affinity | Bioconjugate chemistry | 2,023 | D000939:Epitopes; D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments |
Task before Indian Psychiatry Today: Commentary. | In this commentary on the article, "The Task Before Psychiatry Today Redux: STSPIR," (Singh, 2014)[20], the author, while agreeing with most of the paper's findings, proposes a rather parallel judgment that intersects at the same paths ahead. There is a need for widespread and easily available essential mental health s... | 10.4103/0973-1229.193080 | 28,031,626 | Mens sana monographs | 2,016 | ||
[Atypical presentation of Gorham-Stout syndrome: Case report]. | Gorham-Stout syndrome is an extremely rare pathology, of unknown etiology. It is characterized by proliferation of vascular channels that causes destruction and reabsorption of the bone matrix. We present a nine year-old male patient with an acute episode characterized by fever, chest pain, respiratory distress and dys... | 25,996,335 | D002648:Child; D006801:Humans; D008297:Male; D010015:Osteolysis, Essential; D013577:Syndrome | Archivos argentinos de pediatria | 2,015 | ||
Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1. | The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of glucose homeostasis and has been successfully targeted for the treatment of type 2 diabetes. Recently described biased GLP-1R agonists with selective reductions in β-arrestin versus G protein coupling show improved metabolic actions in vivo. How... | 10.1016/j.bcp.2021.114656 | 34,129,856 | D000818:Animals; D002460:Cell Line; D000077270:Exenatide; D005786:Gene Expression Regulation; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D050417:Insulin-Secreting Cells; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011725:Pyridines; D000071560:beta-Arrestin 2 | Biochemical pharmacology | 2,021 | C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D011725:Pyridines; D000071560:beta-Arrestin 2; C443645:ethyl-7-(3-nitrophenyl)-5,8a-dimethyl-6-methoxycarbonyl-2,3,8,8a-tetrahydro-7H-oxazolo(3,2-a)pyridin-8-carboxylate; D000077270:Exenatide |
Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity. | 3-Phosphoinositide-dependent protein kinase-1 (PDK1) plays a central role in signal transduction pathways that activate phosphoinositide 3-kinase. Despite its key role as an upstream activator of enzymes such as protein kinase B and p70 ribosomal protein S6 kinase, the regulatory mechanisms controlling PDK1 activity ar... | 10.1074/jbc.M105916200 | 11,481,331 | D064413:3-Phosphoinositide-Dependent Protein Kinases; D000595:Amino Acid Sequence; D001692:Biological Transport; D002462:Cell Membrane; D002478:Cells, Cultured; D004789:Enzyme Activation; D004791:Enzyme Inhibitors; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010766:Phosphorylation; D017346:Prote... | The Journal of biological chemistry | 2,001 | D004791:Enzyme Inhibitors; C076715:pervanadate; D014638:Vanadates; D014443:Tyrosine; D019061:src-Family Kinases; D064413:3-Phosphoinositide-Dependent Protein Kinases; C578562:PDPK1 protein, human; D017346:Protein Serine-Threonine Kinases |
[What methods can we use to measure inflammation in the asthmatic child?]. | Pulmonary function tests remain the best method to assess underlying bronchial inflammation, particularly distal airway flow. However, these tests are limited in their ability to differentiate treatment-reversible small airway obstruction from definitive remodeling related to a viral infection. The increased availabili... | 10.1016/j.arcped.2008.02.009 | 18,407,473 | D001249:Asthma; D001706:Biopsy; D001944:Breath Tests; D018893:Bronchoalveolar Lavage; D001999:Bronchoscopy; D004804:Eosinophils; D006801:Humans; D007249:Inflammation; D007958:Leukocyte Count; D008168:Lung; D009569:Nitric Oxide; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie | 2,008 | D009569:Nitric Oxide |
Electrophoretic and cytogenetic studies of Chironomus utahensis. | Cellulose acetate electrophoresis of Chironomus utahensis hemolymph demonstrated a six-band pattern for hemoglobins. Three major and three minor bands made up the electropherogram. Slight variations from this general pattern were found in less than 10 percent of the population and may represent ontogenetic changes, gen... | 10.1093/oxfordjournals.jhered.a108735 | 1,010,932 | D000818:Animals; D002875:Chromosomes; D004175:Diptera; D005260:Female; D006454:Hemoglobins; D007621:Karyotyping; D007814:Larva; D008297:Male; D009024:Morphogenesis; D011110:Polymorphism, Genetic; D012469:Salivary Glands | The Journal of heredity | 1,976 | D006454:Hemoglobins |
The CAG repeat in SCA12 functions as a cis element to up-regulate PPP2R2B expression. | PPP2R2B, a protein widely expressed in neurons, regulates the protein phosphatase 2A (PP2A) activity for dephosphorylation of tau and other substrates. CAG repeat expansion at the 5'-end of the PPP2R2B gene causes autosomal dominant spinocerebellar ataxia type 12. In the present study, we investigated the roles of CAG ... | 10.1007/s00439-010-0843-2 | 20,533,062 | D004268:DNA-Binding Proteins; D006801:Humans; D016297:Mutagenesis, Site-Directed; D009474:Neurons; D016133:Polymerase Chain Reaction; D011506:Proteins; D014157:Transcription Factors; D015533:Transcriptional Activation; D015854:Up-Regulation | Human genetics | 2,010 | D004268:DNA-Binding Proteins; D011506:Proteins; D014157:Transcription Factors; C055473:enhancer-binding protein AP-4 |
[Evaluation of DDD and VVIR pacemakers with gated radionuclide ventriculography]. | Gated radionuclide ventriculography was performed in 53 patients, with 29 DDD and 24 VVIR pacemakers. Ejection fraction and regional contractility was studied in three conditions: a) At rest. b) With tachycardia after exercise. And c) With induced tachycardia at rest. At a rate similar to the one reached with the exerc... | 2,236,794 | D005069:Evaluation Studies as Topic; D015637:Gated Blood-Pool Imaging; D006801:Humans; D010138:Pacemaker, Artificial | Revista espanola de cardiologia | 1,990 | ||
Patients' Perceptions Toward Human-Artificial Intelligence Interaction in Health Care: Experimental Study. | BACKGROUND
It is believed that artificial intelligence (AI) will be an integral part of health care services in the near future and will be incorporated into several aspects of clinical care such as prognosis, diagnostics, and care planning. Thus, many technology companies have invested in producing AI clinical applica... | 10.2196/25856 | 34,842,535 | D001185:Artificial Intelligence; D003695:Delivery of Health Care; D006801:Humans; D011795:Surveys and Questionnaires; D013672:Technology; D035502:Trust | Journal of medical Internet research | 2,021 | |
Quantification of somatic mutation flow across individual cell division events by lineage sequencing. | Mutation data reveal the dynamic equilibrium between DNA damage and repair processes in cells and are indispensable to the understanding of age-related diseases, tumor evolution, and the acquisition of drug resistance. However, available genome-wide methods have a limited ability to resolve rare somatic variants and th... | 10.1101/gr.238543.118 | 30,459,213 | D002455:Cell Division; D002460:Cell Line; D056915:DNA Copy Number Variations; D004252:DNA Mutational Analysis; D005838:Genotype; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D059010:Single-Cell Analysis; D059008:Time-Lapse Imaging | Genome research | 2,018 | |
Fatalities and Catastrophic Injuries in Football. | In brief Football fatality and catastrophic injury data for 1976 through 1981 are compared with earlier data. The purpose is to analyze the data in regard to rule and equipment changes that have taken place in football since 1976 and to demonstrate the reduction in fatalities and catastrophic injuries. Fatality data fo... | 10.1080/00913847.1982.11947346 | 29,283,831 | The Physician and sportsmedicine | 1,982 | ||
The measurement of pressure and flow in the microcirculation: application to physiological and clinical problems. | The analysis of hemodynamic phenomena at the level of microscopic blood vessels of diameters ranging from 10(-2)-10(-3) cm is currently based on direct measurements of plasma pressure and red blood cell velocity in in-vivo conditions. Pressure measurements are performed with active pressure measurement systems via cann... | 995,072 | D000818:Animals; D001783:Blood Flow Velocity; D001795:Blood Pressure Determination; D003201:Computers; D004582:Electronics, Medical; D006439:Hemodynamics; D006801:Humans; D008833:Microcirculation; D009862:Online Systems; D055095:Optics and Photonics; D013997:Time Factors; D014159:Transducers; D014743:Videotape Recordin... | Medical progress through technology | 1,976 | ||
Uric acid protects erythrocytes from ozone-induced changes. | Uric acid effectively reduced hemolysis and methemoglobin formation in bovine and swine erythrocytes bubbled with ozone in vitro. In bovine erythrocytes, formation of thiobarbituric acid-reactive material was inhibited by uric acid, but there was little immediate protection for the swine cells. Antioxidant protection w... | 10.1016/s0013-9351(87)80041-5 | 3,608,939 | D000818:Animals; D002417:Cattle; D004912:Erythrocytes; D006461:Hemolysis; D066298:In Vitro Techniques; D007700:Kinetics; D008054:Lipid Peroxides; D008706:Methemoglobin; D010126:Ozone; D013552:Swine; D014527:Uric Acid | Environmental research | 1,987 | D008054:Lipid Peroxides; D014527:Uric Acid; D010126:Ozone; D008706:Methemoglobin |
Analysis of organic esters of plasticizer in indoor air by GC-MS and GC-FPD. | The aim of this study was to assess the performance of a method of analyzing organic esters of plasticizer in indoor air by sampling air in a charcoal tube and extracting the esters in toluene using a gas chromatography-mass spectrometer (GC-MS) and flame photometric detector (FPD). An internal standardization method w... | 10.1021/es001914o | 11,505,983 | D016902:Air Pollution, Indoor; D002849:Chromatography, Gas; D004784:Environmental Monitoring; D004952:Esters; D006801:Humans; D019570:Inhalation Exposure; D010783:Photometry; D010968:Plasticizers; D012680:Sensitivity and Specificity | Environmental science & technology | 2,001 | D004952:Esters; D010968:Plasticizers |
Chemosensitization of androgen-independent prostate cancer with neutral endopeptidase. | PURPOSE
We investigated whether neutral endopeptidase (NEP) could augment chemosensitivity to anticancer drugs by promoting protein kinase C (PKC)delta-mediated mitochondrial apoptosis in prostate cancer (PC) cells.
EXPERIMENTAL DESIGN
Human PC cell lines LNCaP and PC-3, and a normal prostate epithelial cell line (Pr... | 10.1158/1078-0432.ccr-0798-3 | 14,734,478 | D000728:Androgens; D017304:Annexin A5; D000972:Antineoplastic Agents, Phytogenic; D017209:Apoptosis; D002478:Cells, Cultured; D019008:Drug Resistance, Neoplasm; D004847:Epithelial Cells; D005047:Etoposide; D006801:Humans; D008297:Male; D008928:Mitochondria; D009376:Neoplasms, Hormone-Dependent; D015260:Neprilysin; D063... | Clinical cancer research : an official journal of the American Association for Cancer Research | 2,004 | D000728:Androgens; D017304:Annexin A5; D000972:Antineoplastic Agents, Phytogenic; C086164:CGS 24592; D063065:Organophosphonates; D011994:Recombinant Proteins; D010649:Phenylalanine; D005047:Etoposide; C497258:PRKCD protein, human; D011493:Protein Kinase C; D051745:Protein Kinase C-delta; D015260:Neprilysin |
Modeling and Uncertainty Quantification of Vapor Sorption and Diffusion in Heterogeneous Polymers. | A high-fidelity model of kinetic and equilibrium sorption and diffusion is developed and exercised. The gas-diffusion model is coupled with a triple-sorption mechanism: Henry's law absorption, Langmuir adsorption, and pooling or clustering of molecules at higher partial pressures. Sorption experiments are conducted and... | 10.1002/cphc.201500372 | 26,274,619 | Chemphyschem : a European journal of chemical physics and physical chemistry | 2,015 | ||
SCAR Marker for Gender Identification in Date Palm (Phoenix dactylifera L.) at the Seedling Stage. | Date palm (Phoenix dactylifera L.) is cultivated in arid and semiarid regions worldwide. Given the dioecious nature of this plant, gender identification is very important at the seedling stage. Molecular markers are very effective tools that help in gender identification at this stage. A sequence characterized amplifie... | 10.1155/2018/3035406 | 30,417,007 | International journal of genomics | 2,018 | ||
Perinatal testosterone contributes to mid-to-post pubertal sex differences in risk for binge eating in male and female rats. | Exposure to testosterone early in life may contribute to sex differences and pubertal changes in risk for eating pathology (i.e., females > males, after pubertal onset). Specifically, perinatal testosterone permanently alters brain structure/function and drives the masculinization of several sex-differentiated behavior... | 10.1037/abn0000334 | 29,528,677 | D000818:Animals; D056912:Binge-Eating Disorder; D002032:Bulimia; D005247:Feeding Behavior; D005260:Female; D008297:Male; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D012727:Sex Characteristics; D012741:Sexual Maturation; D013739:Testosterone | Journal of abnormal psychology | 2,018 | D013739:Testosterone |
Pediatric clinical pharmacology: an introduction to a series of educational papers. | Drug therapy is a very powerful tool to improve the medical outcome of children. Despite this fact, pediatricians still commonly prescribe drug formulations that were developed for adults. In this series of educational papers related to pediatric clinical pharmacology, we aim to raise awareness on different aspects of ... | 10.1007/s00431-012-1921-3 | 23,292,033 | D002626:Chemistry, Pharmaceutical; D006801:Humans; D009359:Neonatology; D010372:Pediatrics; D010601:Pharmacology, Clinical; D060735:Pharmacovigilance; D036302:Therapeutic Human Experimentation | European journal of pediatrics | 2,013 | |
Effect of exogenous progesterone on superovulatory response in heifers inseminated with fresh or frozen semen. | Superovulation in cattle normally involves the administration of gonadotrophins at specific times of the oestrous cycle, followed by the induction of luteolysis and insemination with high quality semen. The first aim of this experiment was to examine the effect of supplementary progesterone when used in conjunction wit... | 10.1530/jrf.0.1000505 | 8,021,870 | D000818:Animals; D002417:Cattle; D015925:Cryopreservation; D004973:Estrus Synchronization; D005260:Female; D007315:Insemination, Artificial; D011374:Progesterone; D012662:Semen Preservation; D013480:Superovulation | Journal of reproduction and fertility | 1,994 | D011374:Progesterone |
Heart and Estrogen/progestin Replacement Study (HERS): design, methods, and baseline characteristics. | The Heart and Estrogen/progestin Replacement Study (HERS) is a randomized, double-blind, placebo-controlled trial designed to test the efficacy and safety of estrogen plus progestin therapy for prevention of recurrent coronary heart disease (CHD) events in women. The participants are postmenopausal women with a uterus ... | 10.1016/s0197-2456(98)00010-5 | 9,683,309 | D000368:Aged; D003327:Coronary Disease; D004311:Double-Blind Method; D015914:Estrogen Replacement Therapy; D004967:Estrogens; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate; D008875:Middle Aged; D012307:Risk Factors | Controlled clinical trials | 1,998 | D004967:Estrogens; D017258:Medroxyprogesterone Acetate |
Effect of shaking speed on immobilization of cephalosporin C acylase: Correlation between protein distribution and properties of the immobilized enzymes. | During enzyme immobilization, enzyme activity and protein distribution are affected by various factors such as enzyme load, temperature, and pH. In general, two types of protein distribution patterns (heterogeneous or homogeneous) are observed inside a porous carrier, owing to differences in preparation parameters. Dur... | 10.1002/btpr.3063 | 32,776,709 | D002384:Catalysis; D004795:Enzyme Stability; D004800:Enzymes, Immobilized; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D049452:Green Fluorescent Proteins; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010399:Penicillin Amidase; D011993:Recombinant Fusion Proteins; D013696:Temperature | Biotechnology progress | 2,021 | D004800:Enzymes, Immobilized; D029968:Escherichia coli Proteins; D011993:Recombinant Fusion Proteins; D049452:Green Fluorescent Proteins; D010399:Penicillin Amidase |
Informed consent in physical medicine and rehabilitation. The physician/patient relationship--the doctor as a fiduciary. | This article reviews the principle of informed consent and the ethical and legal bases upon which it rests. The process of obtaining an appropriate informed consent is explored, and the elements that make a consent valid are delineated. The principles of substitute decision-making and the special rules applied to circu... | 10.1016/s1047-9651(01)00002-x | 12,122,844 | D004995:Ethics, Professional; D006801:Humans; D007258:Informed Consent; D010810:Physical and Rehabilitation Medicine; D010817:Physician-Patient Relations; D012046:Rehabilitation; D014342:Truth Disclosure | Physical medicine and rehabilitation clinics of North America | 2,002 | |
Bank voles (Myodes glareolus) and house mice (Mus musculus musculus; M. m. domesticus) in Europe are each parasitized by their own distinct species of Aspiculuris (Nematoda, Oxyurida). | The molecular phylogeny and morphology of the oxyuroid nematode genus Aspiculuris from voles and house mice has been examined. Worms collected from Myodes glareolus in Poland, Eire and the UK are identified as Aspiculuris tianjinensis, previously known only from China, while worms from Mus musculus from a range of loca... | 10.1017/S0031182015000864 | 26,302,680 | D000818:Animals; D003411:Arvicolinae; D001483:Base Sequence; D005075:Biological Evolution; D018509:DNA, Helminth; D004272:DNA, Mitochondrial; D004275:DNA, Ribosomal; D003576:Electron Transport Complex IV; D005060:Europe; D005260:Female; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D010123:Oxyuriasis; D0... | Parasitology | 2,015 | D018509:DNA, Helminth; D004272:DNA, Mitochondrial; D004275:DNA, Ribosomal; D003576:Electron Transport Complex IV |
Signatures of excited-state quantum phase transitions in quantum many-body systems: Phase space analysis. | Using the Husimi quasiprobability distribution, we investigate the phase space signatures of excited-state quantum phase transitions (ESQPTs) in the Lipkin-Meshkov-Glick and coupled top models. We show that the ESQPT is evinced by the dynamics of the Husimi function, that exhibits a distinct time dependence in the diff... | 10.1103/PhysRevE.104.034119 | 34,654,165 | Physical review. E | 2,021 | ||
Two alleles detected for HLA-DZ alpha on the basis of a polymorphic restriction site in the third exon. | The restriction enzyme ApaI has been used to define Restriction Fragment Length Polymorphism (RFLP) within the DZ alpha gene. Digestion of genomic DNA of 96 individuals with ApaI reveals the existence of two different patterns. Both homozygous and heterozygous individuals were detected. Hardy-Weinberg analysis indicate... | 10.1111/j.1399-0039.1987.tb01602.x | 2,890,222 | D000483:Alleles; D005091:Exons; D005787:Gene Frequency; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D005838:Genotype; D006681:HLA-D Antigens; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length | Tissue antigens | 1,987 | D006681:HLA-D Antigens |
The effect of introducing a smaller and lighter basketball on female basketball players' shot accuracy. | Our study examined whether the introduction of a smaller and lighter basketball (no. 6) affected the accuracy of female basketball players' shots at the basket. The International Basketball Federation (FIBA) introduced a size 6 ball in the 2004/2005 season to improve the efficiency and accuracy of technical elements, p... | 10.2478/v10078-012-0014-8 | 23,486,286 | Journal of human kinetics | 2,012 | ||
Phenotypic characterization of complete CSNB in the inbred research beagle: how common is CSNB in research and companion dogs? | PURPOSE
Although congenital stationary night blindness (CSNB) has been described in a Japanese beagle dog research colony, certain clinical correlates with human CSNB have not yet been described, nor has an estimate of frequency of the condition been made in inbred and outbred beagle populations.
METHODS
A beagle wit... | 10.1007/s10633-018-9653-y | 30,051,304 | D000221:Adaptation, Ocular; D000818:Animals; D017849:Animals, Inbred Strains; D003623:Dark Adaptation; D004285:Dogs; D004596:Electroretinography; D015785:Eye Diseases, Hereditary; D040181:Genetic Diseases, X-Linked; D009216:Myopia; D009755:Night Blindness; D010641:Phenotype; D012029:Refraction, Ocular; D012160:Retina; ... | Documenta ophthalmologica. Advances in ophthalmology | 2,018 | |
Oxygen vacancy-driven orbital multichannel Kondo effect in Dirac nodal line metals IrO2 and RuO2. | Strong electron correlations have long been recognized as driving the emergence of novel phases of matter. A well recognized example is high-temperature superconductivity which cannot be understood in terms of the standard weak-coupling theory. The exotic properties that accompany the formation of the two-channel Kondo... | 10.1038/s41467-020-18407-7 | 32,958,776 | Nature communications | 2,020 | ||
[Effect of bisoprolol in coronary heart disease. Effect on cardiovascular parameters and ischemic ST depression: studies on the duration of the effect]. | A beta-adrenoceptor antagonist, bisoprolol, was given by mouth, 5 and 10 mg doses per 24 hours, in a double-blind randomized cross-over trial to 12 patients with stable coronary-heart disease. Ischaemia criteria proved not reproducible in control ergometry tests on two patients, leaving ten patients for further evaluat... | 10.1055/s-2008-1069478 | 6,150,839 | D000319:Adrenergic beta-Antagonists; D000368:Aged; D000787:Angina Pectoris; D017298:Bisoprolol; D002986:Clinical Trials as Topic; D003327:Coronary Disease; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines | Deutsche medizinische Wochenschrift (1946) | 1,984 | D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D017298:Bisoprolol |
Methamphetamines pretreatment and the vulnerability of the striatum to methamphetamine neurotoxicity. | Pretreatment with intermittent low-dose administrations of stimulants increases mesostriatal dopamine transmission upon administration of a challenge dose. This occurs without evidence of a long-term dopamine or serotonin depletion. The purpose was to examine whether pretreatment with low doses of methamphetamine enhan... | 10.1016/0306-4522(95)00587-0 | 8,861,054 | D000818:Animals; D003342:Corpus Striatum; D004298:Dopamine; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid; D008297:Male; D008694:Methamphetamine; D017551:Microdialysis; D051381:Rats; D017207:Rats, Sprague-Dawley | Neuroscience | 1,996 | D018698:Glutamic Acid; D008694:Methamphetamine; D004298:Dopamine |
Hypoxia induces production of nitric oxide and reactive oxygen species in glomus cells of rat carotid body. | The carotid body is an arterial chemoreceptor organ that senses arterial pO(2) and pH. Previous studies have indicated that both reactive oxygen species (ROS) and nitric oxide (NO) are important potential mediators that may be involved in the response of the carotid body to hypoxia. However, whether their production by... | 10.1007/s00441-006-0178-4 | 16,534,602 | D000818:Animals; D002344:Carotid Body; D005260:Female; D019793:Fluorescein; D016650:Fluorescein-5-isothiocyanate; D019084:Fluorescent Antibody Technique, Indirect; D000860:Hypoxia; D007150:Immunohistochemistry; D008297:Male; D009252:NADPH Dehydrogenase; D009569:Nitric Oxide; D052248:Nitric Oxide Synthase Type I; D05225... | Cell and tissue research | 2,006 | C111205:4,5-diaminofluorescein; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III; D009252:NADPH Dehydrogenase; D016650:Fluorescein-5-isothiocyanate; D019793:Fluorescein |
The coming of age of molecular tumor profiling. | While adjuvant chemotherapy has been shown to modestly improve survival for patients with resected non-small cell lung cancer (NSCLC), the morbidities associated with administration of these drugs are substantial. The identification of molecular profiles that may predict a patient's need for adjuvant therapy may prove ... | 10.1053/j.semtcvs.2011.03.005 | 21,807,290 | D002289:Carcinoma, Non-Small-Cell Lung; D017024:Chemotherapy, Adjuvant; D020869:Gene Expression Profiling; D005820:Genetic Testing; D006801:Humans; D008175:Lung Neoplasms; D058990:Molecular Targeted Therapy; D018579:Patient Selection; D011237:Predictive Value of Tests; D011379:Prognosis | Seminars in thoracic and cardiovascular surgery | 2,011 | |
Corroles that bind with high affinity to both apo and holo transferrin. | The interactions of transferrin (Tf) with the water soluble corrole 1 and with its gallium (1-Ga) and manganese (1-Mn) complexes were studied to establish the possible utilization of corrole-transferrin conjugates for targeting these corroles to cells that express the transferrin receptor. The protein, in both its iron... | 10.1016/j.jinorgbio.2007.10.026 | 18,180,041 | D004591:Electrophoresis, Polyacrylamide Gel; D005708:Gallium; D008274:Magnesium; D015394:Molecular Structure; D011166:Porphyrins; D011485:Protein Binding; D012044:Regression Analysis; D014168:Transferrin | Journal of inorganic biochemistry | 2,008 | D011166:Porphyrins; D014168:Transferrin; C431863:corrole; D005708:Gallium; D008274:Magnesium |
Clinical and hormonal effects of ketoconazole on hirsutism in women. | Twelve women affected by functional postpuberal hirsutism were administered daily with 400 mg of ketoconazole. A significant reduction in the levels of concentration of circulating androgens (T, DEA-S, D4) was observed. A rapid clinical improvement of hirsutism and acne was noted and was even appreciable after treatmen... | 3,225,137 | D000293:Adolescent; D000328:Adult; D000728:Androgens; D005260:Female; D006628:Hirsutism; D006801:Humans; D007654:Ketoconazole | International journal of tissue reactions | 1,988 | D000728:Androgens; D007654:Ketoconazole | |
Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia. | BACKGROUND
We have repeatedly reported that American ginseng (AG) with a specific ginsenoside profile significantly decreases postprandial glycemia. Whether this effect is reproducible using AG with a different profile is unknown. We therefore investigated the effect of a different batch of AG on glycemia following a 7... | 10.1038/sj.ejcn.1601550 | 12,571,655 | D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose; D018592:Cross-Over Studies; D005260:Female; D036145:Ginsenosides; D006801:Humans; D006943:Hyperglycemia; D007328:Insulin; D008297:Male; D005894:Panax; D008517:Phytotherapy; D028321:Plant Preparations; D019518:Postprandial Period; D012016:Reference Valu... | European journal of clinical nutrition | 2,003 | D001786:Blood Glucose; D036145:Ginsenosides; D007328:Insulin; D028321:Plant Preparations |
[Treatment of hemihyperkinesis by stereotaxic surgery on the basal ganglia]. | Hemihyperkinesia develops in childhood as a rule as a consequence of meningoencephalitis. The authors operated on 60 patients, performing 76 stereotaxic interventions on the basal ganglia of the brain. It is established that these operations are the only effective method of treatment of the disease. A marked therapeuti... | 341,516 | D000293:Adolescent; D000328:Adult; D001479:Basal Ganglia; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006948:Hyperkinesis; D008297:Male; D008590:Meningoencephalitis; D013238:Stereotaxic Techniques | Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko | 1,977 | ||
Effect of anandamide on erythrocyte survival. | The endocannabinoid anandamide (Arachidonylethanolamide, AEA) is known to induce apoptosis in a wide variety of nucleated cells. The present study explored whether anandamide induces suicidal death of erythrocytes or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserin... | 10.1159/000110714 | 17,975,305 | D000111:Acetylcysteine; D017304:Annexin A5; D001095:Arachidonic Acids; D002118:Calcium; D002470:Cell Survival; D002712:Chlorides; D016861:Cyclooxygenase Inhibitors; D003600:Cytosol; D063388:Endocannabinoids; D004912:Erythrocytes; D005434:Flow Cytometry; D006801:Humans; D009997:Osmotic Pressure; D010718:Phosphatidylseri... | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2,007 | D017304:Annexin A5; D001095:Arachidonic Acids; D002712:Chlorides; D016861:Cyclooxygenase Inhibitors; D063388:Endocannabinoids; D010718:Phosphatidylserines; D053284:Polyunsaturated Alkamides; D002118:Calcium; C078814:anandamide; D000111:Acetylcysteine |
Pharmacokinetics and tolerability of single escalating doses of fampridine sustained-release tablets in patients with multiple sclerosis: a Phase I-II, open-label trial. | BACKGROUND
Fampridine (4-aminopyridine) is a potassium channel-blocking agent that has been reported to have therapeutic potential for improving walking and mobility in patients with multiple sclerosis (MS). A sustained-release (SR) formulation of fampridine was developed to improve the agent's pharmacokinetic profile ... | 10.1016/j.clinthera.2009.10.008 | 19,922,891 | D015761:4-Aminopyridine; D000368:Aged; D019540:Area Under Curve; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multi... | Clinical therapeutics | 2,009 | D003692:Delayed-Action Preparations; D026902:Potassium Channel Blockers; D015761:4-Aminopyridine |
Merging Pincer Motifs and Potential Metal-Metal Cooperativity in Cobalt Dinitrogen Chemistry: Efficient Catalytic Silylation of N2 to N(SiMe3 )3. | Using a pyrazolate-bridged dinucleating ligand that provides two proximate pincer-type PNN binding sites ("two-in-one pincer"), different synthetic routes have been developed towards its dicobalt(I) complex 2 that features a twice deprotonated ligand backbone and two weakly activated terminal N2 substrate ligands direc... | 10.1002/anie.202101387 | 33,829,680 | Angewandte Chemie (International ed. in English) | 2,021 | ||
Solar-driven aromatic aldehydes: green production from mandelic acid derivatives by a Co(ii)/C3N4 combined catalyst in aqueous media. | According to the requirements for sustainable development, reclaiming fine chemicals from wastewater under mild conditions is an extremely significant line of research. A low-cost and high-efficiency polydentate chelate- and polymeric Co(ii)-based complex (Co-L)-loaded C3N4 photocatalyst (Co-L/C3N4) was constructed and... | 10.1039/d1ra08256f | 35,425,574 | RSC advances | 2,022 | ||
Recent Progress in the Discovery and Development of Monoclonal Antibodies against Viral Infections. | Monoclonal antibodies (mAbs), the new revolutionary class of medications, are fast becoming tools against various diseases thanks to a unique structure and function that allow them to bind highly specific targets or receptors. These specialized proteins can be produced in large quantities via the hybridoma technique in... | 10.3390/biomedicines10081861 | 36,009,408 | Biomedicines | 2,022 | ||
Understanding the genetic structure of Symplocos laurina Wall. populations using nuclear gene markers. | To characterize the genetic diversity of present populations of Symplocos laurina, which grow in the montane forests in India, we analyzed the DNA sequences of a nuclear gene. Using the 881 bp sequence of cytosolic Glyceraldehyde-3-phosphate dehydrogenase gene, we detected 24 haplotypes among 195 individuals sampled fr... | 10.1007/s10709-009-9410-y | 19,784,858 | D002467:Cell Nucleus; D029624:Ferns; D005819:Genetic Markers; D014644:Genetic Variation; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D006239:Haplotypes; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA | Genetica | 2,010 | D005819:Genetic Markers; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases |
Hepatitis B virus X protein partially substitutes for E1A transcriptional function during adenovirus infection. | Lack of an in vitro culture system for human hepatitis B virus has hampered the ability to address fundamental questions regarding the viral life cycle and the effect of viral gene products during productive infection. To study the activity of HBV X protein (HBx) in the context of a viral infectious cycle, we provided ... | 10.1006/viro.1996.0079 | 8,607,273 | D017498:Adenovirus E1 Proteins; D004261:DNA Replication; D004279:DNA, Viral; D017353:Gene Deletion; D015967:Gene Expression Regulation, Viral; D006515:Hepatitis B virus; D006801:Humans; D012333:RNA, Messenger; D012367:RNA, Viral; D015534:Trans-Activators; D015533:Transcriptional Activation; D014407:Tumor Cells, Culture... | Virology | 1,996 | D017498:Adenovirus E1 Proteins; D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein |
[Low-field magnetic resonance imaging for rheumatoid arthritis]. | Magnetic resonance imaging (MRI) as a cross-sectional imaging procedure allows a three-dimensional representation of musculature, ligaments, tendons, capsules, synovial membranes, bones and cartilage with high resolution quality. An activity assessment is further possible by application of a contrast medium (gadolinium... | 10.1007/s00393-009-0547-y | 19,894,053 | D000328:Adult; D018501:Antirheumatic Agents; D001172:Arthritis, Rheumatoid; D001842:Bone and Bones; D003287:Contrast Media; D042241:Early Diagnosis; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D021621:Imagin... | Zeitschrift fur Rheumatologie | 2,010 | D018501:Antirheumatic Agents; D003287:Contrast Media |
Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth. | BACKGROUND
PAX6, a transcription factor, has currently been suggested to function as a tumor suppressor in glioblastoma and to act as an early differentiation marker for neuroendocrine cells. The androgen receptor (AR) plays a pivotal role in prostate cancer development and progression due to its transcriptional activi... | 10.1002/pros.21052 | 19,790,232 | D045744:Cell Line, Tumor; D049109:Cell Proliferation; D056970:Co-Repressor Proteins; D005136:Eye Proteins; D015870:Gene Expression; D018398:Homeodomain Proteins; D006801:Humans; D008297:Male; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D010957:Plasmids; D011471:Prostatic Neoplasms; D... | The Prostate | 2,010 | D056970:Co-Repressor Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D011944:Receptors, Androgen; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins |
NK cell lymphoblastic lymphoma in the masticator space: a case of non-Hodgkin lymphoma with challenging maxillofacial manifestation and immunophenotype. | Clinical and pathologic findings in extranodal non-Hodgkin lymphoma (NHL) often raise challenging problems in diagnosis. We demonstrate the first established case of lymphoma with precursor natural killer (NK) cell origin in the oral and maxillofacial region. An 81-year-old Japanese man had an enlarged facial mass main... | 10.1016/j.tripleo.2009.07.024 | 19,846,330 | D000369:Aged, 80 and over; D000951:Antigens, Neoplasm; D017252:CD3 Complex; D015704:CD4 Antigens; D019002:CD56 Antigen; D019070:Cell Lineage; D006258:Head and Neck Neoplasms; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural; D008228:Lymphoma, Non-Hodgkin; D008297:Male; D008410:Masticatory Muscle... | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics | 2,009 | D000951:Antigens, Neoplasm; D017252:CD3 Complex; D015704:CD4 Antigens; D019002:CD56 Antigen |
Towards a short questionnaire for stepwise assessment of upper limb function, pain and stiffness in Duchenne muscular dystrophy. | PURPOSE
Duchenne muscular dystrophy can lead to upper extremity limitations, pain and stiffness. In a previous study, these domains have been investigated using extensive questionnaires, which are too time-consuming for clinical practice. This study aimed at gaining insight into the underlying dimensions of these quest... | 10.1080/09638288.2016.1274336 | 28,084,836 | D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020388:Muscular Dystrophy, Duchenne; D010146:Pain; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D034941:Upper Extrem... | Disability and rehabilitation | 2,018 | |
Opium Use and Head and Neck Cancers: A Matched Case-Control Study in Iran. | BACKGROUND
Head and Neck (H and N) cancers include malignant tumors of the nasal cavity, pharynx, paranasal sinuses, oral cavity, larynx and salivary glands. Opium use might be related to these cancers. The aim of this study was to investigate the relation between Opium and its Derivatives (O and D) use and the inciden... | 10.31557/APJCP.2020.21.3.783 | 32,212,808 | D000368:Aged; D000428:Alcohol Drinking; D016022:Case-Control Studies; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D009892:Opium; D012907:Smoking | Asian Pacific journal of cancer prevention : APJCP | 2,020 | D009892:Opium |
Thermal treatment of Cs-exchanged chabazite by hot isostatic pressing to support decommissioning of Fukushima Daiichi Nuclear Power Plant. | Ion exchange materials are used widely for the removal of radionuclides from contaminated water at nuclear licensed sites, during normal operating procedures, decommissioning and in accident clean-up, such as the ongoing recovery operation at the Fukushima Daiichi nuclear power plant. Framework silicate inorganic ion e... | 10.1016/j.jhazmat.2021.125250 | 33,581,672 | Journal of hazardous materials | 2,021 | ||
Nanomechanical properties of TiO2 granular thin films. | Post-deposition annealing effects on nanomechanical properties of granular TiO2 films on soda-lime glass substrates were studied. In particular, the effects of Na diffusion on the films' mechanical properties were examined. TiO2 photocatalyst films, 330 nm thick, were prepared by dip-coating using a TiO2 sol, and were ... | 10.1021/am100455q | 20,715,790 | D001672:Biocompatible Materials; D008422:Materials Testing; D008567:Membranes, Artificial; D049329:Nanostructures; D010316:Particle Size; D013499:Surface Properties; D013718:Tensile Strength; D014025:Titanium | ACS applied materials & interfaces | 2,010 | D001672:Biocompatible Materials; D008567:Membranes, Artificial; C009495:titanium dioxide; D014025:Titanium |
Respiratory effects of intrathecal capsaicin in arthritic and non-arthritic rats. | The study determined the effects of intrathecal injection of 50 micrograms of capsaicin on respiration in rats with adjuvant arthritis as well as in control animals. Whole body plethysmographic measurements of steady-state frequency, tidal volume, and minute volume of respiration were made 3 hours and for up to 11 days... | 10.1016/0024-3205(84)90284-4 | 6,203,007 | D000818:Animals; D001168:Arthritis; D001169:Arthritis, Experimental; D001835:Body Weight; D002211:Capsaicin; D007278:Injections, Spinal; D008297:Male; D010146:Pain; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration; D013373:Substance P | Life sciences | 1,984 | D013373:Substance P; D002211:Capsaicin |
[Research on DPOAE of guinea pigs treated with gentamicin]. | This study was designed to disclose the specific changes of distortion product otoacoustic emission (DPOAE), including DP-gram and I/O-gram in guinea pigs treated with GM for 10 and 17 days. Forty guinea pigs were divided into four groups:group I (treated with GM for 10 days), group II (treated with normal saline for 1... | 18,435,257 | D000161:Acoustic Stimulation; D000818:Animals; D003051:Cochlea; D005260:Female; D005839:Gentamicins; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous; D010469:Perceptual Distortion; D011897:Random Allocation | Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi | 2,008 | D005839:Gentamicins | |
Anti-IL-5 therapy in patients with severe eosinophilic asthma - clinical efficacy and possible criteria for treatment response. | BACKGROUND
Interleukin-5 (IL-5) antibodies represent a promising therapeutic option for patients with severe eosinophilic asthma. To date, no official treatment response criteria exist. In this study, simple criteria for treatment response applicable to all asthma patients were used to evaluate clinical efficacy and pr... | 10.1186/s12890-018-0689-2 | 30,021,546 | D000305:Adrenal Cortex Hormones; D000328:Adult; D018927:Anti-Asthmatic Agents; D061067:Antibodies, Monoclonal, Humanized; D001249:Asthma; D018450:Disease Progression; D004804:Eosinophils; D005260:Female; D006801:Humans; D007167:Immunotherapy; D015848:Interleukin-5; D016015:Logistic Models; D008297:Male; D008875:Middle ... | BMC pulmonary medicine | 2,018 | D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents; D061067:Antibodies, Monoclonal, Humanized; D015848:Interleukin-5; C434107:mepolizumab |
Highly automated protein backbone resonance assignment within a few hours: the "BATCH" strategy and software package. | Sequential resonance assignment represents an essential step towards the investigation of protein structure, dynamics, and interaction surfaces. Although the experimental sensitivity has significantly increased in recent years, with the availability of high field magnets and cryogenically cooled probes, resonance assig... | 10.1007/s10858-009-9314-2 | 19,367,368 | D000465:Algorithms; D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular; D011487:Protein Conformation; D011506:Proteins; D012984:Software; D013997:Time Factors; D025801:Ubiquitin; D014584:User-Computer Interface | Journal of biomolecular NMR | 2,009 | D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D011506:Proteins; D025801:Ubiquitin |
Spacetime and flux tube S-matrices at finite coupling for N=4 supersymmetric Yang-Mills theory. | We propose a nonperturbative formulation of planar scattering amplitudes in N=4 supersymmetric Yang-Mills theory, or, equivalently, polygonal Wilson loops. The construction is based on the operator product expansion approach and introduces a new decomposition of the Wilson loop in terms of fundamental building blocks n... | 10.1103/PhysRevLett.111.091602 | 24,033,023 | Physical review letters | 2,013 | ||
13 C Flux Analysis Reveals that Rebalancing Medium Amino Acid Composition can Reduce Ammonia Production while Preserving Central Carbon Metabolism of CHO Cell Cultures. | 13 C metabolic flux analysis (MFA) provides a rigorous approach to quantify intracellular metabolism of industrial cell lines. In this study, 13 C MFA was used to characterize the metabolic response of Chinese hamster ovary (CHO) cells to a novel medium variant designed to reduce ammonia production. Ammonia inhibits gr... | 10.1002/biot.201700518 | 29,405,605 | D000596:Amino Acids; D000641:Ammonia; D000818:Animals; D000911:Antibodies, Monoclonal; D016466:CHO Cells; D002244:Carbon; D003412:Cricetulus; D003470:Culture Media; D006031:Glycosylation; D064688:Metabolic Flux Analysis; D011994:Recombinant Proteins | Biotechnology journal | 2,018 | D000596:Amino Acids; D000911:Antibodies, Monoclonal; D003470:Culture Media; D011994:Recombinant Proteins; D002244:Carbon; D000641:Ammonia |
Prevalence and associated factors of retinal vein occlusion in the Korean National Health and Nutritional Examination Survey, 2008-2012: A cross-sectional observational study. | Retinal vein occlusion (RVO) is the second most common retinal vascular diseases and there are only a few Asian population-based studies with small samples. Hypertension is one of a modifiable risk factor of RVO, but no recent studies have shown the relationship between RVO and hypertension control status. We aimed to ... | 10.1097/MD.0000000000005185 | 27,858,854 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D015995:Prevalence; D056910:Republic of Korea; D012170:Retinal Vein Occlusion; D012307:Risk Factors; D055815:Young ... | Medicine | 2,016 | |
The blood oxygen transport system. A numerical simulation of capillary-tissue respiratory gas exchange. | A theoretical model of the process of respiratory gas exchange between capillary and tissue is described, with special reference to the importance of variations in blood properties. The volume of tissue supplied with oxygen from a single vessel, as a function of the blood flowrate (u), hematocrit (h), and 2,3 diphospho... | 10.1111/j.0954-6820.1975.tb06499.x | 239,526 | D002196:Capillaries; D002199:Capillary Permeability; D002245:Carbon Dioxide; D004163:Diphosphoglyceric Acids; D004912:Erythrocytes; D006400:Hematocrit; D006454:Hemoglobins; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008433:Mathematics; D008954:Models, Biological; D010100:Oxygen; D010101:Oxygen Consumption; D0... | Acta medica Scandinavica. Supplementum | 1,975 | D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen |
Anatomical Evaluation of Root and Root Canal Morphology of Permanent Mandibular Dentition among the Saudi Arabian Population: A Systematic Review. | This study aimed to conduct a compendious review of root canal morphology of "permanent mandibular teeth in different regions of Saudi Arabia" to obtain a large sample representing the total population. A detailed search through the databases Web of Science, Scopus, and PubMed was conducted following the PRISMA guideli... | 10.1155/2022/2400314 | 35,958,809 | D003786:Dental Pulp Cavity; D003817:Dentition; D006801:Humans; D008334:Mandible; D008963:Molar; D012529:Saudi Arabia; D014092:Tooth Root | BioMed research international | 2,022 | |
The radiation response of cells from 9L gliosarcoma tumours is correlated with [F18]-EF5 uptake. | PURPOSE
Tumour hypoxia affects cancer biology and therapy-resistance in both animals and humans. The purpose of this study was to determine whether EF5 ([2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide]) binding and/or radioactive drug uptake correlated with single-dose radiation response in 9L ... | 10.3109/09553000903242172 | 19,995,239 | D000818:Animals; D015687:Cell Hypoxia; D002470:Cell Survival; D019788:Fluorodeoxyglucose F18; D018316:Gliosarcoma; D008297:Male; D011836:Radiation Tolerance; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D051381:Rats; D011916:Rats, Inbred F344 | International journal of radiation biology | 2,009 | D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18 |
Imaging and lung disease: uses and interpretation. | Diagnostic imaging has undergone a profound revolution since the first computed tomography (CT) unit was conceived in 1971; CT is now an integral part of daily practice in thoracic radiology, and has reached a relative technological maturity. Magnetic Resonance Imaging (MRI) has been introduced more recently. Technical... | 10.1016/0962-8479(93)90003-G | 8,369,507 | D001987:Bronchiectasis; D001989:Bronchiolitis Obliterans; D006801:Humans; D008168:Lung; D008171:Lung Diseases; D008175:Lung Neoplasms; D011009:Pneumoconiosis; D011658:Pulmonary Fibrosis; D012507:Sarcoidosis; D014057:Tomography, X-Ray Computed | Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease | 1,993 | |
[Problems of early diagnostics of diseases of skeletal and muscular system of workers in harmful working conditions in the Voronezh region]. | On the basis of studying of final acts of periodic medical examinations, medical records and these passports of health the analysis of a condition of incidence of skeletal and muscular system of production workers in the Voronezh region is carried out. The low indicator of active identification of this pathology in pri... | 23,785,807 | D000328:Adult; D042241:Early Diagnosis; D006801:Humans; D015994:Incidence; D007221:Industry; D008403:Mass Screening; D008875:Middle Aged; D009140:Musculoskeletal Diseases; D009784:Occupational Diseases; D016272:Occupational Health; D012426:Russia; D011795:Surveys and Questionnaires; D000078329:Workforce | Meditsina truda i promyshlennaia ekologiia | 2,013 | ||
Visualization of active devices and automatic slice repositioning ("SnapTo") for MRI-guided interventions. | The accurate visualization of interventional devices is crucial for the safety and effectiveness of MRI-guided interventional procedures. In this paper, we introduce an improvement to the visualization of active devices. The key component is a fast, robust method ("CurveFind") that reconstructs the three-dimensional tr... | 10.1002/mrm.22307 | 20,373,408 | D000465:Algorithms; D000818:Animals; D001707:Biopsy, Needle; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D053783:Magnetic Resonance Imaging, Interventional; D019047:Phantoms, Imaging; D013552:Swine; D014652:Vascular Diseases | Magnetic resonance in medicine | 2,010 | |
Discrete unified gas kinetic scheme for all Knudsen number flows. III. Binary gas mixtures of Maxwell molecules. | Recently a discrete unified gas kinetic scheme (DUGKS) in a finite-volume formulation based on the Boltzmann model equation has been developed for gas flows in all flow regimes. The original DUGKS is designed for flows of single-species gases. In this work, we extend the DUGKS to flows of binary gas mixtures of Maxwell... | 10.1103/PhysRevE.97.053306 | 29,906,980 | Physical review. E | 2,018 | ||
Antero posterior elongation of midbrain in traumatic brain injury- significant sign yet a mistaken entity. | BACKGROUND
Antero posterior elongation of the midbrain is observed occasionally in severe traumatic brain injury and generally implies a bad outcome. The objective of the study was to document midbrain elongation and identify the implications of this finding.
METHODS
This prospective study included 100 patients with ... | 10.1080/02688697.2018.1432748 | 29,383,966 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000070642:Brain Injuries, Traumatic; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages; D008297:Male; D008636:Mesencephalon; D008875:Middle Aged; D011149:Pons; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372... | British journal of neurosurgery | 2,018 | |
Ultra-wideband all-fiber tunable Tm/Ho-co-doped laser at 2 μm. | We demonstrate an all-fiber tunable Tm/Ho-codoped laser operating in the 2 μm wavelength region. The wavelength tuning range of the Tm/Ho-codoped fiber laser (THFL) with 1-m length of Tm/Ho-codoped fiber (THDF) was from 1727 nm to 2030 nm. Efficient short wavelength operation and ultra-wide wavelength tuning range of 3... | 10.1364/OE.22.025976 | 25,401,631 | D000669:Amplifiers, Electronic; D004867:Equipment Design; D005336:Fiber Optic Technology; D053844:Lasers, Solid-State | Optics express | 2,014 | |
Artifacts and artifact removal in optical coherence tomographic angiography. | Optical coherence tomographic angiography (OCTA) enables rapid imaging of retinal vasculature in three dimensions. While the technique has provided quantification of healthy vessels as well as pathology in several diseases, it is not unusual for OCTA data to contain artifacts that may influence measurement outcomes or ... | 10.21037/qims-20-730 | 33,654,681 | Quantitative imaging in medicine and surgery | 2,021 | ||
Distinct causal mechanisms of attentional guidance by working memory and repetition priming in early visual cortex. | Human attention may be guided by representations held in working memory (WM) and also by priming from implicit memory. Neurophysiological data suggest that WM and priming may be associated with distinct neural mechanisms, but this prior evidence is only correlative. Furthermore, the role of the visual cortex in attenti... | 10.1523/JNEUROSCI.6243-11.2012 | 22,399,767 | D001288:Attention; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D010775:Photic Stimulation; D011930:Reaction Time; D060865:Repetition Priming; D014793:Visual Cortex; D014796:Visual Perception; D055815:Young Adult | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,012 | |
Cord blood cardiac troponin I, fetal Doppler velocimetry, and acid base status at birth. | OBJECTIVE
To analyze the association between umbilical cord cardiac troponin I (cTnI), obstetric Doppler, and birth acidemia.
METHOD
This prospective observational study was conducted on 58 singleton pregnancies at 3 Brazilian hospitals. Umbilical and middle cerebral artery Doppler velocimetry were performed 24 h pri... | 10.1016/j.ijgo.2007.08.007 | 17,963,762 | D000138:Acidosis; D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011446:Prospective Studies; D019210:Troponin I; D016216:Ultrasonography, Prenatal | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics | 2,008 | D019210:Troponin I |
Brachytherapy in orbital tumors. | PURPOSE
To evaluate whether the use of iridium-192 brachytherapy would reduce the incidence of complications noted with external beam radiation therapy in patients with orbital tumors.
METHODS AND MATERIALS
This study is a retrospective review of a clinical series of 25 patients with various orbital tumors treated wi... | 10.1016/s0161-6420(97)30113-4 | 9,307,644 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001918:Brachytherapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007496:Iridium Radioisotopes; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009918:Orbital Neoplasms; D011879:Radiotherap... | Ophthalmology | 1,997 | D007496:Iridium Radioisotopes |
Heparin Administered to Anopheles in Membrane Feeding Assays Blocks Plasmodium Development in the Mosquito. | Innovative antimalarial strategies are urgently needed given the alarming evolution of resistance to every single drug developed against Plasmodium parasites. The sulfated glycosaminoglycan heparin has been delivered in membrane feeding assays together with Plasmodium berghei-infected blood to Anopheles stephensi mosqu... | 10.3390/biom10081136 | 32,752,200 | D000818:Animals; D000852:Anopheles; D000962:Antimalarials; D004032:Diet; D005260:Female; D006493:Heparin; D008288:Malaria; D051379:Mice; D000072138:Mosquito Vectors; D033661:Oocysts; D010962:Plasmodium berghei; D015053:Zygote | Biomolecules | 2,020 | D000962:Antimalarials; D006493:Heparin |
Mucinous metaplasia of the endometrium: current concepts. | OBJECTIVES
The objective of this review was to discuss the highly variable terminology describing mucinous metaplasia of the endometrium, histologic features and characteristic findings by special stains and immunohistochemistry, differential diagnostic challenges, current treatment and prognosis.
METHODS
A review of... | 25,485,781 | D000368:Aged; D016889:Endometrial Neoplasms; D004717:Endometrium; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia; D011230:Precancerous Conditions | Gynecologic oncology | 2,015 | ||
The effect of a shoe lift on tensor fasciae latae length during standing with an artificial functional leg length discrepancy: An ultrasonic shear wave elastography study. | BACKGROUND
Shortening of tensor fasciae latae is one factor that causes a functional leg length discrepancy. A shoe lift has been used to correct the compensatory posture resulting from the discrepancy. Despite the potential therapeutic benefit of a shoe lift, the mechanism by which it exerts its effect is unclear.
O... | 10.3233/BMR-191755 | 34,459,382 | D054459:Elasticity Imaging Techniques; D006801:Humans; D007866:Leg; D007870:Leg Length Inequality; D012775:Shoes; D013848:Thigh; D014465:Ultrasonics | Journal of back and musculoskeletal rehabilitation | 2,022 | |
Non-Hermitian morphing of topological modes. | Topological modes (TMs) are usually localized at defects or boundaries of a much larger topological lattice1,2. Recent studies of non-Hermitian band theories unveiled the non-Hermitian skin effect (NHSE), by which the bulk states collapse to the boundary as skin modes3-6. Here we explore the NHSE to reshape the wavefun... | 10.1038/s41586-022-04929-1 | 35,922,504 | Nature | 2,022 | ||
Weight, blood pressure, osmolarity, and glucose levels across various stages of Alzheimer's disease and vascular dementia. | Data collected as part of the Canadian Study of Health and Aging were analyzed to determine whether physiological changes associated with Alzheimer's disease are common to other types of dementia and are related more to the severity of cognitive impairment. We found that blood pressure and body mass index decreased wit... | 10.1159/000106623 | 9,137,891 | D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease; D001794:Blood Pressure; D001835:Body Weight; D015140:Dementia, Vascular; D005260:Female; D005947:Glucose; D006801:Humans; D008297:Male; D009994:Osmolar Concentration | Dementia and geriatric cognitive disorders | 1,997 | D005947:Glucose |
Immunologic studies of three family members with the immunodeficiency with hyper-IgM syndrome. | We report the results of immunologic studies in a family in which the father (III-5) and his two daughters (IV-7 and IV-8) had the hyper-IgM syndrome (IHIS). Repeated immunoglobulin levels done on III-5 showed a typical IHIS pattern: low IgG, traces of IgA, and high IgM. IV-7, who also had stage IIA Hodgkin's disease, ... | 10.1007/BF00915483 | 6,602,145 | D000328:Adult; D001402:B-Lymphocytes; D002675:Child, Preschool; D004406:Dysgammaglobulinemia; D005260:Female; D006689:Hodgkin Disease; D006801:Humans; D006942:Hypergammaglobulinemia; D007111:Immunity, Cellular; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes; D008297:Male; D010375:Pedigree | Journal of clinical immunology | 1,983 | D007075:Immunoglobulin M |
Oxidative stress and caspase-mediated fragmentation of cytoplasmic domain of erythrocyte band 3 during blood storage. | BACKGROUND
During blood bank storage, red blood cells (RBCs) undergo a number of biological and biochemical alterations collectively referred to as "storage lesions". These injuries include loss and oxidative cross-linking of band 3, the major integral protein of RBC membranes. Denaturation of hemoglobin (Hb) and damag... | 10.2450/2012.009S | 22,890,269 | D001457:Anion Exchange Protein 1, Erythrocyte; D001793:Blood Preservation; D020169:Caspases; D004910:Erythrocyte Membrane; D004912:Erythrocytes; D006801:Humans; D018384:Oxidative Stress | Blood transfusion = Trasfusione del sangue | 2,012 | D001457:Anion Exchange Protein 1, Erythrocyte; D020169:Caspases |
The effects of organic solvents and temperature on the desorption of yeast 3-phosphoglycerate kinase from immunoadsorbent. | Physicochemical parameters governing the elution of yeast 3-phosphoglycerate kinase from its immunoadsorbent were studied. Non-denaturing elution conditions were determined (alkali medium containing 50%, v/v, ethylene glycol) and the method was applied to one-step isolation of enzyme from a crude yeast preparation. | 10.1016/0022-1759(79)90029-2 | 372,447 | D000818:Animals; D000936:Antigen-Antibody Complex; D007106:Immune Sera; D007164:Immunosorbents; D010735:Phosphoglycerate Kinase; D011817:Rabbits; D012441:Saccharomyces cerevisiae; D012997:Solvents; D013696:Temperature | Journal of immunological methods | 1,979 | D000936:Antigen-Antibody Complex; D007106:Immune Sera; D007164:Immunosorbents; D012997:Solvents; D010735:Phosphoglycerate Kinase |
Characterization of the sea urchin mitochondrial transcription factor A reveals unusual features. | Sea urchin mtDNA is transcribed via a different mechanism compared to vertebrates. To gain information on the apparatus of sea urchin mitochondrial transcription we have characterized the DNA binding properties of the mitochondrial transcription factor A (TFAM). The protein contains two HMG box domains but, differently... | 24,184,823 | D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D018983:DNA Footprinting; D004272:DNA, Mitochondrial; D004268:DNA-Binding Proteins; D014644:Genetic Variation; D024101:Mitochondrial Proteins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D011487:Protein Conform... | Mitochondrion | 2,014 | D004272:DNA, Mitochondrial; D004268:DNA-Binding Proteins; D024101:Mitochondrial Proteins; D014157:Transcription Factors; C422562:mitochondrial transcription factor A | |
Heterozygous C-propeptide mutations in COL1A1: osteogenesis imperfecta type IIC and dense bone variant. | Osteogenesis imperfecta type IIC (OI IIC) is a rare variant of lethal OI that has been considered to be an autosomal recessive trait. Twisted, slender long bones with dense metaphyseal margins and normal vertebral bodies in OI IIC contrast with crumpled, thick long bones and multiple vertebral compression fractures in ... | 10.1002/ajmg.a.34152 | 21,834,035 | D001483:Base Sequence; D015519:Bone Density; D001842:Bone and Bones; D002648:Child; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D005260:Female; D006579:Heterozygote; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D008297:Male; D009154:Mutation; D010013:Osteogenesis Imper... | American journal of medical genetics. Part A | 2,011 | D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D011498:Protein Precursors |
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