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Prognosis of patients with recurrent facial palsy. | No studies to date have classified recurrent facial palsy according to the House-Brackmann grade, thus limiting any comparisons between patients with recurrent and primary facial palsy. The aims of the study were to analyze the degree of recovery from recurrent facial palsy and factors affecting the degree of recovery ... | 10.1007/s00405-011-1581-3 | 21,448,613 | D000200:Action Potentials; D000328:Adult; D004558:Electric Stimulation; D004576:Electromyography; D005154:Facial Nerve; D005158:Facial Paralysis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020127:Recovery of Function; D012008:Recurrence | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery | 2,012 | |
A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation. | Melatonin is substantially reported to possess anti-inflammatory properties. In the present study, we synthesized a novel melatonin derivative, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), which displayed superior anti-inflammatory properties to its parent compound. Further, we explored its underlying mechanisms in cell... | 25,689,174 | D055371:Acute Lung Injury; D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D000893:Anti-Inflammatory Agents; D002460:Cell Line; D051546:Cyclooxygenase 2; D004195:Disease Models, Animal; D005260:Female; D007211:Indoles; D058847:Inflammasomes; D007249:Inflammation; D053583:Interleukin-1beta; D015850:Inter... | Toxicology and applied pharmacology | 2,015 | D033942:Adaptor Proteins, Vesicular Transport; D000893:Anti-Inflammatory Agents; D007211:Indoles; D058847:Inflammasomes; D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D010080:Oxazoles; D017382:Reactive Oxygen Species; C476286:TICAM-1 protein, mouse; D014409:Tumor Necrosis Factor-alpha; ... | |
Worry-specific versus self-tailored internet-based treatments for generalized anxiety disorder, with scheduled support or support on demand: A pilot factorial design trial. | Studies suggest that internet-delivered cognitive behaviour therapy (ICBT) can be effective when treating generalized anxiety disorder (GAD). This pilot factorial design study examined the effects of two types of ICBT (worry-specific and self-tailored treatment), and two support types (scheduled weekly support and supp... | 10.1016/j.invent.2022.100531 | 35,371,926 | Internet interventions | 2,022 | ||
A 9-gene prognostic signature for kidney renal clear cell carcinoma overall survival based on co-expression and regression analyses. | This research attempted to screen potential signatures associated with KIRC progression and overall survival by weighted gene co-expression network analysis (WGCNA) and Cox regression. The KIRC-associated mRNA expression and clinical data were accessed from The Cancer Genome Atlas (TCGA) database. Differentially expres... | 10.1111/cbdd.14141 | 36,053,927 | D006801:Humans; D002292:Carcinoma, Renal Cell; D007668:Kidney; D007680:Kidney Neoplasms; D016547:Kinesins; D011379:Prognosis; D012044:Regression Analysis; D020869:Gene Expression Profiling | Chemical biology & drug design | 2,023 | C502735:KIF18A protein, human; D016547:Kinesins |
In an Absolute State: Elevated Use of Absolutist Words Is a Marker Specific to Anxiety, Depression, and Suicidal Ideation. | Absolutist thinking is considered a cognitive distortion by most cognitive therapies for anxiety and depression. Yet, there is little empirical evidence of its prevalence or specificity. Across three studies, we conducted a text analysis of 63 Internet forums (over 6,400 members) using the Linguistic Inquiry and Word C... | 10.1177/2167702617747074 | 30,886,766 | Clinical psychological science : a journal of the Association for Psychological Science | 2,018 | ||
Crosses between insertion and point mutations in lambda gene cI: stimulation of neighboring recombination by heterology. | Intragenic recombination between lambda cI point mutations and insertions was studied in four-factor crosses. In crosses between two point mutations, there is a linear relationship between recombination frequency and distance. However, in crosses between an insertion and point mutations, there is additional recombinati... | 10.1093/genetics/108.2.277 | 6,094,303 | D010582:Bacteriophage lambda; D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; D005090:Exodeoxyribonucleases; D008957:Models, Genetic; D009154:Mutation; D011938:Rec A Recombinases; D011995:Recombination, Genetic; D012097:Repressor Proteins; D014157:Transcription Factors; D014764:Viral Proteins; D054334:... | Genetics | 1,984 | D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C016649:phage repressor proteins; D011938:Rec A Recombinases; D005090:Exodeoxyribonucleases; C043586:exo protein, Bacteriop... |
Metagenomic Analysis Reveals A Possible Association Between Respiratory Infection and Periodontitis. | Periodontitis is an inflammatory disease that is characterized by progressive destruction of the periodontium and causes tooth loss in adults. Periodontitis is known to be associated with dysbiosis of the oral microflora, which is often linked to various diseases. However, the complexity of plaque microbial communities... | 10.1016/j.gpb.2021.07.001 | 34,252,627 | D006801:Humans; D000328:Adult; D054892:Metagenome; D056186:Metagenomics; D010518:Periodontitis; D064307:Microbiota; D064806:Dysbiosis; D000900:Anti-Bacterial Agents | Genomics, proteomics & bioinformatics | 2,022 | D000900:Anti-Bacterial Agents |
Preoperative laboratory testing for total hip arthroplasty: Unnecessary tests or a helpful prognosticator. | BACKGROUND
The last decade has seen increasing initiatives to improve health care delivery while decreasing financial expenditures, as particularly exemplified by the implementation of bundled payments for lower extremity arthroplasty, which hold the providers responsible for the both the quality and cost of these proc... | 10.1016/j.jos.2019.09.019 | 31,668,911 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D001806:Blood Urea Nitrogen; D003404:Creatinine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D057234:Preoperative Period; D012964:Sodium; D01448... | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association | 2,020 | D012964:Sodium; D003404:Creatinine |
The Effect of Surrounding Vegetation on Basal Stem Measurements Acquired Using Low-Cost Depth Sensors in Urban and Native Forest Environments. | Three colour and depth (RGB-D) devices were compared, to assess the effect of depth image misalignment, resulting from simultaneous localisation and mapping (SLAM) error, due to forest structure complexity. Urban parkland (S1) was used to assess stem density, and understory vegetation (≤1.3 m) was assessed in native wo... | 10.3390/s23083933 | 37,112,278 | D065928:Forests | Sensors (Basel, Switzerland) | 2,023 | |
The GSI Cancer Therapy Project. | At the Heavy Ion Research Institute GSI in Darmstadt an experimental cancer treatment program with a five years duration has been developed. A new method for cancer treatment with ions is applied, using rasterscan method in addition to an active pulse to pulse variation of ion beam properties, including the energy, int... | 10.1007/BF03038880 | 10,394,389 | D000047:Academies and Institutes; D005858:Germany; D006801:Humans; D009369:Neoplasms; D010315:Particle Accelerators; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D011881:Radiotherapy, Computer-Assisted | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] | 1,999 | |
Little difference between minimum inhibitory concentrations of Mycobacterium tuberculosis wild-type organisms determined with BACTEC MGIT 960 and Middlebrook 7H10. | The MIC wild-type (WT) distribution for Mycobacterium tuberculosis in BACTEC 960 MGIT is not defined, which may result in poor reproducibility for drug susceptibility testing (DST), as several DST methods with different breakpoints are in use. In a comparison between MGIT and Middlebrook 7H10 medium of seven first- and... | 25,640,156 | D000995:Antitubercular Agents; D003470:Culture Media; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases | 2,015 | D000995:Antitubercular Agents; D003470:Culture Media | |
The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity. | Retinoic acid, a hormonally active form of vitamin A, is produced in vivo in a two step process: retinol is oxidized to retinal and retinal is oxidized to retinoic acid. Retinal dehydrogenase type II (RalDH2) catalyzes this last step in the production of retinoic acid in the early embryo, possibly producing this putati... | 10.1021/bi9900471 | 10,320,326 | D000445:Aldehyde Oxidoreductases; D000447:Aldehydes; D000595:Amino Acid Sequence; D000818:Animals; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009243:NAD; D011487:Protein Conformation; D050697:Retinal Dehydrogenase; D017386:Sequence Homology, Am... | Biochemistry | 1,999 | D000447:Aldehydes; D009243:NAD; D000445:Aldehyde Oxidoreductases; D050697:Retinal Dehydrogenase |
Cardiac repolarization during hypoglycaemia in type 1 diabetes: impact of basal renin-angiotensin system activity. | AIMS
Hypoglycaemia-induced cardiac arrhythmias may be involved in the pathogenesis of the 'dead-in-bed syndrome' in patients with type 1 diabetes. Evidence suggests that the renin-angiotensin system (RAS) influences the occurrence of arrhythmias. The aim of this study was to explore if basal RAS activity affects cardia... | 10.1093/europace/eun137 | 18,534,966 | D000328:Adult; D001786:Blood Glucose; D018592:Cross-Over Studies; D016757:Death, Sudden, Cardiac; D003922:Diabetes Mellitus, Type 1; D004562:Electrocardiography; D004837:Epinephrine; D005260:Female; D006339:Heart Rate; D006801:Humans; D007003:Hypoglycemia; D007328:Insulin; D008297:Male; D008875:Middle Aged; D011379:Pro... | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology | 2,008 | D001786:Blood Glucose; D007328:Insulin; D004837:Epinephrine |
The palliative care knowledge of nursing home staff: The EU FP7 PACE cross-sectional survey in 322 nursing homes in six European countries. | BACKGROUND
The provision of high-quality palliative care in nursing homes (NHs) is a major challenge and places demands on the knowledge and skills of the staff.
AIM
This study assesses the palliative care knowledge of staff in NHs in Europe.
DESIGN
Cross-sectional study using structured survey Setting/participants... | 10.1177/0269216318785295 | 29,972,343 | D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005060:Europe; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D020380:Needs Assessment; D009735:Nursing Homes; D009740:Nursing Staff; D010166:Palliative Care; D011795:Surveys and Quest... | Palliative medicine | 2,018 | |
Validation of an iCare Health Monitor smartphone application in the assessment of vital signs among stroke survivors in a poor-resource country. | Background
Frequent and accurate monitoring of blood pressure (BP) is a vital part of stroke management. There is therefore the need for availability of simple, portable and accurate devices for monitoring BP at any point in time.
Objective
To determine the validity and reliability of the iCare Health Monitor (iCHM) ... | 10.1177/20552076221143228 | 36,532,115 | Digital health | 2,022 | ||
Pharmacokinetics and peritoneal penetration of moxifloxacin in peritonitis. | OBJECTIVES
To investigate the penetration of moxifloxacin into peritoneal exudate in patients with complicated intra-abdominal infections (cIAIs).
PATIENTS AND METHODS
Patients (n = 10) with evidence of peritonitis who required surgery with drainage of the abdominal cavity received a single intravenous infusion of mo... | 10.1093/jac/dkl305 | 16,895,940 | D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents; D019540:Area Under Curve; D001202:Ascitic Fluid; D001372:Aza Compounds; D001682:Biological Availability; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D0105... | The Journal of antimicrobial chemotherapy | 2,006 | D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin |
Hypermethylation of the myogenic gene Myf-3 in human breast carcinomas. | The methylation status of Myf-3 was studied in 34 human primary breast carcinomas and 9 normal breast tissues. One third of the carcinomas contained hypermethylated Myf-3. All normal tissues contained unmethylated Myf-3. Myf-3 hypermethylation was more common in poorly differentiated grade 3 tumours than in better diff... | 8,712,752 | D000230:Adenocarcinoma; D001483:Base Sequence; D001940:Breast; D001943:Breast Neoplasms; D004273:DNA, Neoplasm; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008745:Methylation; D017570:MyoD Protein; D009361:Neoplasm Invasiveness; D011003:Ploidies; D011110:Polymorphism, Genetic; D011960:Receptors, Estr... | Anticancer research | 1,996 | D004273:DNA, Neoplasm; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D015534:Trans-Activators | |
Evaluation of an electrolyte repletion protocol for cardiac surgery intensive care patients. | BACKGROUND
Implementation of electrolyte repletion protocols to facilitate and ensure the safety of electrolyte control is common practice in intensive care units (ICUs). However, few protocols have been evaluated and validated.
OBJECTIVE
To evaluate the effectiveness and safety of an electrolyte repletion protocol i... | 10.4212/cjhp.v66i2.1231 | 23,616,673 | The Canadian journal of hospital pharmacy | 2,013 | ||
Pros and cons of chest wall reconstruction using prosthetic meshes in a two-layer fashion. | A 46-year-old woman with giant chondrosarcoma of the sternum underwent wide full-thickness resection of the anterior chest wall, which included the pericardium and lung. The free rectus abdominus musculocutaneous flap was transplanted onto prosthetic meshes placed in two layers. While stability and esthetic effect were... | 10.1055/s-2002-35740 | 12,457,315 | D001859:Bone Neoplasms; D002813:Chondrosarcoma; D005260:Female; D006801:Humans; D008875:Middle Aged; D010496:Pericardium; D011138:Polytetrafluoroethylene; D013249:Sternum; D013524:Surgical Flaps; D013526:Surgical Mesh | The Thoracic and cardiovascular surgeon | 2,002 | D011138:Polytetrafluoroethylene |
Breaking Boundaries: Toward Consistent Gender-Sensitive Language in Sexual and Reproductive Health Guidelines. | This review assesses gender-sensitive language in sexual and reproductive health (SRH) guidelines, including a guideline for polycystic ovary syndrome. We conducted a systematic search across databases like Medline, EMBASE, and Cochrane until July 31, 2023, using terms related to gender-inclusivity, SRH, and guideline ... | 10.1055/s-0043-1777323 | 38,052,243 | Seminars in reproductive medicine | 2,023 | ||
Prefrontal and anterior cingulate cortex neurons encode attentional targets even when they do not apparently bias behavior. | Neurons in anterior cingulate and prefrontal cortex (ACC/PFC) carry information about behaviorally relevant target stimuli. This information is believed to affect behavior by exerting a top-down attentional bias on stimulus selection. However, attention information may not necessarily be a biasing signal but could be a... | 10.1152/jn.00027.2016 | 27,193,317 | D000200:Action Potentials; D000704:Analysis of Variance; D000818:Animals; D001288:Attention; D015982:Bias; D002755:Choice Behavior; D003463:Cues; D006179:Gyrus Cinguli; D008253:Macaca mulatta; D008297:Male; D009474:Neurons; D010775:Photic Stimulation; D017397:Prefrontal Cortex; D011930:Reaction Time; D013028:Space Perc... | Journal of neurophysiology | 2,016 | |
[Diagnostic value of clinical indices in syndrome differentiation of chronic hepatitis B: an exploration based on receiver operating characteristic curves and stepwise discriminant analysis]. | OBJECTIVE
To explore the diagnostic value of 75 commonly used clinical laboratory markers for differentiation of traditional Chinese medicine syndromes such as liver and gallbladder damp-heat and liver depression and spleen deficiency in patients with chronic hepatitis B.
METHODS
A total of 422 patients with chronic ... | 10.3736/jcim20121208 | 23,257,130 | D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D005260:Female; D019694:Hepatitis B, Chronic; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D012372:ROC Curve; D055815:Young Adult | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine | 2,012 | |
Cohort Analysis of a 24-Week Randomized Controlled Trial to Assess the Efficacy of a Novel, Partial Meal Replacement Program Targeting Weight Loss and Risk Factor Reduction in Overweight/Obese Adults. | Our aim was to design and evaluate a weight-loss program, including a partial meal replacement program, point-of-care testing and face-to-face and smartphone app support, appropriate for delivery in a community pharmacy setting. Overweight or obese adults (n = 146, 71.2% female, 48.18 ± 11.75 years old) were recruited ... | 27,153,085 | D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D062407:Meals; D008875:Middle Aged; D050177:Overweight; D012307:Risk Factors; D013997:Time Factors; D015431:Weight Loss | Nutrients | 2,016 | ||
Bacterially expressed rat retinol-binding protein is functional for retinol and transthyretin bindings. | Retinol-binding protein (RBP) was expressed in Escherichia coli using the cDNA for rat RBP, and characterized. The expressed RBP was fused to maltose-binding protein (MBP) at the N-terminal end (MBP-RBP), and MBP was enzymatically removed from the MBP-RBP with proteinase factor Xa. The binding of retinol and transthyre... | 10.3177/jnsv.42.257 | 8,906,627 | D018528:ATP-Binding Cassette Transporters; D000818:Animals; D015153:Blotting, Western; D002352:Carrier Proteins; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D015951:Factor Xa; D015870:Gene Expression; D058619:Maltose-Binding Prot... | Journal of nutritional science and vitaminology | 1,996 | D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D058619:Maltose-Binding Proteins; D009004:Monosaccharide Transport Proteins; D011228:Prealbumin; D011993:Recombinant Fusion Proteins; D012177:Retinol-Binding Proteins; C461599:maltose transport system, E coli; D01480... |
Phosphorylated HP1α-Nucleosome Interactions in Phase Separated Environments. | In the nucleus, transcriptionally silent genes are sequestered into heterochromatin compartments comprising nucleosomes decorated with histone H3 Lys9 trimethylation and a protein called HP1α. This protein can form liquid-liquid droplets in vitro and potentially organize heterochromatin through a phase separation mecha... | 10.1021/jacs.3c06481 | 37,870,432 | D006801:Humans; D009707:Nucleosomes; D006570:Heterochromatin; D006657:Histones; D002868:Chromosomal Proteins, Non-Histone; D010766:Phosphorylation; D014157:Transcription Factors | Journal of the American Chemical Society | 2,023 | D009707:Nucleosomes; D006570:Heterochromatin; D006657:Histones; D002868:Chromosomal Proteins, Non-Histone; D014157:Transcription Factors |
Short course therapy with cefuroxime axetil for acute otitis media: results of a randomized multicenter comparison with amoxicillin/clavulanate. | BACKGROUND
Otitis media is a common infection of childhood. Increasing antibiotic resistance rates among the principal causative pathogens, Streptococcus pneumoniae and Haemophilus influenzae, are associated with failure of first line agents.
OBJECTIVE
This open, randomized, multicenter study compared the clinical ef... | 10.1097/00006454-199910000-00004 | 10,530,579 | D000208:Acute Disease; D019980:Amoxicillin-Potassium Clavulanate Combination; D001424:Bacterial Infections; D002444:Cefuroxime; D002511:Cephalosporins; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010034... | The Pediatric infectious disease journal | 1,999 | D002511:Cephalosporins; D019980:Amoxicillin-Potassium Clavulanate Combination; D002444:Cefuroxime; C040738:cefuroxime axetil |
[Effect of angiotensin converting enzyme genotype on endothelial function in healthy subjects]. | OBJECTIVE
Endothelial dysfunction is an early marker of atherosclerosis. Angiotensin II and nitric oxide have important roles in maintaining the vascular tone. The existence of the angiotensin converting enzyme (ACE) gene polymorphisms has been known, and deletion (D) of the allele has been associated with coronary art... | 18,258,525 | D000328:Adult; D001783:Blood Flow Velocity; D001916:Brachial Artery; D002784:Cholesterol; D008076:Cholesterol, HDL; D003324:Coronary Artery Disease; D003331:Coronary Vessels; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular; D005260:Female; D005838:Genotype; D006801:Humans; D017078:Laser-Doppler Flowmetry... | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology | 2,008 | D008076:Cholesterol, HDL; D002784:Cholesterol; D007703:Peptidyl-Dipeptidase A | |
Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer. | Tumor cell-derived extracellular vesicles (EVs) are being explored as circulating biomarkers, but it is unclear whether bulk measurements will allow early cancer detection. We hypothesized that a single-EV analysis (sEVA) technique could potentially improve diagnostic accuracy. Using pancreatic cancer (PDAC), we analyz... | 10.1126/sciadv.abm3453 | 35,452,280 | D064007:Ataxia Telangiectasia Mutated Proteins; D021441:Carcinoma, Pancreatic Ductal; D000067128:Extracellular Vesicles; D006801:Humans; D010190:Pancreatic Neoplasms; D016283:Proto-Oncogene Proteins p21(ras); D016159:Tumor Suppressor Protein p53; D010190:Pancreatic Neoplasms | Science advances | 2,022 | D016159:Tumor Suppressor Protein p53; D064007:Ataxia Telangiectasia Mutated Proteins; D016283:Proto-Oncogene Proteins p21(ras) |
Icariin exhibits protective effects on cisplatin-induced cardiotoxicity via ROS-mediated oxidative stress injury in vivo and in vitro. | BACKGROUND
Cisplatin-induced cardiotoxicity severely limits its clinical application as an antitumor drug and increases the risk of cardiovascular disease. Icariin (ICA), the main flavonoid isolated from Epimedii Folium, has been demonstrated to have various beneficial effects on cardiovascular disease. However, the pr... | 10.1016/j.phymed.2022.154331 | 35,878,553 | D000818:Animals; D017209:Apoptosis; D066126:Cardiotoxicity; D002318:Cardiovascular Diseases; D002945:Cisplatin; D005419:Flavonoids; D051379:Mice; D018384:Oxidative Stress; D019869:Phosphatidylinositol 3-Kinases; D017382:Reactive Oxygen Species | Phytomedicine : international journal of phytotherapy and phytopharmacology | 2,022 | D005419:Flavonoids; D017382:Reactive Oxygen Species; D002945:Cisplatin; C056599:icariin |
The determinant of healthcare childbirth among young people in Indonesia. | Background: Young people is a vulnerable period of the emergence of various problems that may occur especially to those who are pregnant. The study was aimed to analyze the determinants of healthcare childbirth among young people in Indonesia in 2017. Design and Methods: The samples of this study were young people (15-... | 10.4081/jphr.2021.1890 | 33,553,060 | Journal of public health research | 2,021 | ||
Chondroitin sulfate proteoglycans of the endothelia of human umbilical vein and arteries and assessment for the adherence of Plasmodium falciparum-infected erythrocytes. | Infection with Plasmodium falciparum during pregnancy leads to chondroitin 4-sulfate-mediated adhesion of the infected red blood cells (IRBCs) in the placenta, causing severe health complications to fetus and the mother. The IRBCs are also frequently found in low density in the umbilical cord of infected placentas. In ... | 10.1016/j.molbiopara.2003.11.009 | 14,747,149 | D000818:Animals; D002448:Cell Adhesion; D011508:Chondroitin Sulfate Proteoglycans; D042783:Endothelial Cells; D004912:Erythrocytes; D005260:Female; D006025:Glycosaminoglycans; D006801:Humans; D037181:Lectins, C-Type; D010920:Placenta; D010963:Plasmodium falciparum; D011247:Pregnancy; D011509:Proteoglycans; D014469:Umbi... | Molecular and biochemical parasitology | 2,004 | D011508:Chondroitin Sulfate Proteoglycans; D006025:Glycosaminoglycans; D037181:Lectins, C-Type; D011509:Proteoglycans; C508322:VCAN protein, human; D033921:Vesicular Transport Proteins; C075430:serglycin; D053675:Versicans |
Relative burden of lung and pleural cancers from exposure to asbestos: a cross-sectional analysis of occupational mortality in England and Wales. | OBJECTIVES
To explore the extent to which asbestos-exposed jobs vary in the ratio of excess mortality from lung cancer to deaths from pleural cancer.
DESIGN
Using data on underlying cause of death and last full-time occupation for 3 688 916 deaths among men aged 20-74 years in England and Wales during 1979-2010, we c... | 10.1136/bmjopen-2019-036319 | 32,273,321 | D000328:Adult; D000368:Aged; D001194:Asbestos; D003430:Cross-Sectional Studies; D004739:England; D006801:Humans; D008168:Lung; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases; D016273:Occupational Exposure; D010997:Pleural Neoplasms; D012907:Smoking; D014852:Wales; D055815:Young... | BMJ open | 2,020 | D001194:Asbestos |
Effects of game-based virtual reality on health-related quality of life in chronic stroke patients: A randomized, controlled study. | In the present study, we aimed to determine whether game-based virtual reality (VR) rehabilitation, combined with occupational therapy (OT), could improve health-related quality of life, depression, and upper extremity function. We recruited 35 patients with chronic hemiparetic stroke, and these participants were rando... | 26,046,499 | D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D000071939:Stroke Rehabilitation; D018910:Video Games; D063367:Virtual Reality Exposure Therapy | Computers in biology and medicine | 2,015 | ||
Learning Through Chain Event Graphs: The Role of Maternal Factors in Childhood Type 1 Diabetes. | Chain event graphs (CEGs) are a graphical representation of a statistical model derived from event trees. They have previously been applied to cohort studies but not to case-control studies. In this paper, we apply the CEG framework to a Yorkshire, United Kingdom, case-control study of childhood type 1 diabetes (1993-1... | 10.1093/aje/kwx171 | 28,535,192 | D000649:Amniocentesis; D001499:Bayes Theorem; D016022:Case-Control Studies; D002585:Cesarean Section; D002648:Child; D036861:Delivery, Obstetric; D003922:Diabetes Mellitus, Type 1; D004522:Educational Status; D005260:Female; D006801:Humans; D016015:Logistic Models; D008423:Maternal Age; D015233:Models, Statistical; D00... | American journal of epidemiology | 2,017 | D012204:Rh-Hr Blood-Group System |
Dental and medical health status and oral health knowledge among visually impaired and sighted female schoolchildren in Riyadh: a comparative study. | BACKGROUND
The impact of visual impairment on oral health in the literature is inconclusive, and the available information on the medical and dental health status of visually impaired children is limited. The aim of this study was to evaluate the dental and medical health status, and to assess the oral health knowledge... | 10.1186/s12903-017-0446-6 | 29,258,491 | D002648:Child; D003430:Cross-Sectional Studies; D003753:Dental Health Surveys; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006304:Health Status; D006801:Humans; D009909:Oral Health; D014786:Vision Disorders; D019987:Visually Impaired Persons | BMC oral health | 2,017 | |
Bursellopsis spaniopogon n. spec. (Ciliophora: Prostomatida): I. Infraciliature and ultrastructure of the somatic and oral cortex. | A description is given of a new species of the genus Bursellopsis Corliss, 1960. Its infraciliature is studied by means of Klein's dry silver technique and Fernández-Galiano's pyridinated silver-carbonate-method. The light microscopical results are supplemented by a comparative scanning and transmission electron micros... | 23,194,604 | European journal of protistology | 1,991 | |||
Diet, microbiota, and the mucus layer: The guardians of our health. | The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of the host representing one of the main external factors shaping the microbiome-host relationship. Diets high in fiber and low in... | 10.3389/fimmu.2022.953196 | 36,177,011 | D059305:Diet, High-Fat; D004043:Dietary Fiber; D017753:Ecosystem; D000069196:Gastrointestinal Microbiome; D009093:Mucus; D000073893:Sugars | Frontiers in immunology | 2,022 | D004043:Dietary Fiber; D000073893:Sugars |
IGF-1 regulates migration and angiogenesis of human endothelial cells. | Recent studies revealed favorable para- and/or autocrine effects of IGF-1 in the pathogenesis of diabetic complications. On the other hand, hyperglycemia is a risk factor for the development of diabetic vascular complications. In this study we examined the effects of high glucose and/or IGF-1 on cell migration and angi... | 10.1507/endocrj.46.suppl_s59 | 12,054,122 | D000730:Androstadienes; D002465:Cell Movement; D002478:Cells, Cultured; D002867:Chromones; D004730:Endothelium, Vascular; D004791:Enzyme Inhibitors; D005419:Flavonoids; D005947:Glucose; D006801:Humans; D007334:Insulin-Like Growth Factor I; D009025:Morpholines; D018919:Neovascularization, Physiologic; D013755:Tetradecan... | Endocrine journal | 1,999 | D000730:Androstadienes; D002867:Chromones; D004791:Enzyme Inhibitors; D005419:Flavonoids; D009025:Morpholines; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D007334:Insulin-Like Growth Factor I; D005947:Glucose; D013755:Tetradecanoylphorbol Acetate; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one;... |
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway. | Chemokines and their receptors show a strong relationship with poor clinical outcomes in various cancers. However, their underlying mechanisms remain to be fully elucidated. In our research, we found C-C chemokine receptor 7 (CCR7) and its ligand chemokine ligand 21 (CCL21) were abnormally abundant in oral squamous cel... | 10.1002/jcp.29525 | 32,017,846 | D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D054421:Chemokine CCL21; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D064593:Heterografts; D006801:Humans; D053614:Janus Kinase 2; D051379:Mice; D009361:Neoplasm Invasiveness; D01... | Journal of cellular physiology | 2,020 | C515478:CCL21 protein, human; C515370:CCR7 protein, human; D054421:Chemokine CCL21; D054400:Receptors, CCR7; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C507924:JAK2 protein, human; D053614:Janus Kinase 2 |
Teaching Radiology to Medical Students in Canada; a Virtual, Integrative, Clinical Approach. | PURPOSE
To construct, apply, and evaluate a multidisciplinary approach in teaching radiology to Canadian medical students.
METHODS
A multidisciplinary team of radiology and other disciplines experts designed an online 5-session course that was delivered to medical students. The topics of each session were clinical ca... | 10.1177/08465371211043562 | 34,569,318 | D002170:Canada; D003479:Curriculum; D006801:Humans; D011859:Radiography; D011871:Radiology; D013337:Students, Medical; D011795:Surveys and Questionnaires | Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes | 2,022 | |
Optimization of post-column photolysis and electrochemical detection for the liquid chromatographic determination of 3-nitro-L-tyrosine. | A new post-column photolysis technology has been developed based on the use of a low pressure, low temperature UV lamp and TiO2 coated knitted reaction coil. As a test case the developed technique was used for the determination of 3-nitro-L-tyrosine by liquid chromatography with electrochemical detection. Different pho... | 10.1016/s0021-9673(98)00487-7 | 9,770,305 | D000818:Animals; D002853:Chromatography, Liquid; D004563:Electrochemistry; D008027:Light; D010782:Photolysis; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D014443:Tyrosine | Journal of chromatography. A | 1,998 | C002744:3-nitrotyrosine; D014443:Tyrosine |
Corruption and oil exploration: expert agreement about the prevention of HIV/AIDS in the Niger Delta of Nigeria. | The Niger Delta, according to the Nigerian Ministry of Health, has a disproportionately high HIV infection rate, which is double the national average. The United Nations Development Program attributes the spiraling HIV infection rate in the region to poverty, migration and gender inequality. This paper examines two com... | 10.1093/her/cym042 | 17,906,312 | D003415:Crime; D003697:Delphi Technique; D005579:Fossil Fuels; D015658:HIV Infections; D006801:Humans; D007221:Industry; D009549:Nigeria; D011795:Surveys and Questionnaires | Health education research | 2,008 | D005579:Fossil Fuels |
Evolution of antifungal agents: past, present, and future. | Important progress has been achieved in antifungal chemotherapy in recent years. Two groups of drugs are now used: those produced by various organisms and those made synthetically. In the first group, only amphotericin B (1956) administered systemically is active in numerous deep mycoses. Although toxicity limits the u... | 10.1093/clinids/9.supplement_1.s4 | 3,544,144 | D000666:Amphotericin B; D000935:Antifungal Agents; D005437:Flucytosine; D006118:Griseofulvin; D006801:Humans; D007654:Ketoconazole; D009181:Mycoses | Reviews of infectious diseases | 1,987 | D000935:Antifungal Agents; D006118:Griseofulvin; D000666:Amphotericin B; D005437:Flucytosine; D007654:Ketoconazole |
The dark perimetric stimulus. | We determined the disappearance eccentricities of dark and bright stimuli of equal size in the inferonasal central visual field using the oculokinetic perimetry technique at different levels of surrounding illumination. The results suggest that a dark stimulus on a bright background has a smaller 'isoptre' than an equa... | 10.1136/bjo.76.5.264 | 1,390,506 | D015350:Contrast Sensitivity; D004584:Electronystagmography; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D010775:Photic Stimulation; D014794:Visual Fields | The British journal of ophthalmology | 1,992 | |
Resilience and affect balance of empty-nest older adults with mild cognitive impairment in poor rural areas of Hunan province, China. | AIM
To evaluate the prevalence of mild cognitive impairment (MCI) within the empty-nest older adults population in poor rural areas of the Hunan province of China, and to explore the effects of resilience and affective balance on cognitive functioning within this specific population.
METHODS
A cross-sectional, multis... | 10.1111/ggi.13601 | 30,706,664 | D000339:Affect; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D016000:Cluster Analysis; D060825:Cognitive Dysfunction; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011203:Poverty; D055500:Resilience, Psychological; D0124... | Geriatrics & gerontology international | 2,019 | |
Convolutional neural networks explain tuning properties of anterior, but not middle, face-processing areas in macaque inferotemporal cortex. | Recent computational studies have emphasized layer-wise quantitative similarity between convolutional neural networks (CNNs) and the primate visual ventral stream. However, whether such similarity holds for the face-selective areas, a subsystem of the higher visual cortex, is not clear. Here, we extensively investigate... | 10.1038/s42003-020-0945-x | 32,385,392 | D000818:Animals; D001931:Brain Mapping; D002540:Cerebral Cortex; D000066499:Facial Recognition; D008251:Macaca; D009415:Nerve Net; D010775:Photic Stimulation | Communications biology | 2,020 | |
Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation. | Progressive liver dysfunction contributes significantly to the development of multiple organ failure after trauma/hemorrhage. This study tested the relative impact of necrotic and apoptotic cell death in a graded model of hemorrhagic shock (mean arterial blood pressure=35+/-5 mmHg for 1, 2, or 3 h, followed by 2 h, 1 h... | 10.1096/fj.02-0624com | 12,773,482 | D000255:Adenosine Triphosphate; D000590:Amino Acid Chloromethyl Ketones; D000818:Animals; D000975:Antioxidants; D017209:Apoptosis; D061945:Caspase Inhibitors; D003497:Cyclic N-Oxides; D015853:Cysteine Proteinase Inhibitors; D022781:Hepatocytes; D007022:Hypotension; D007208:Indocyanine Green; D007511:Ischemia; D008099:L... | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 2,003 | D000590:Amino Acid Chloromethyl Ketones; D000975:Antioxidants; D061945:Caspase Inhibitors; D003497:Cyclic N-Oxides; D015853:Cysteine Proteinase Inhibitors; D013113:Spin Labels; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; D000255:Adenosine Triphosphate; D007208:Indocyanine Green; C001803:tempol |
Disparities in the availability of dental care in metropolitan Toronto. | OBJECTIVES
The availability of dentists as a barrier to access to care has not been thoroughly explored, particularly in large cities. In this study, we aimed to identify disparities in the availability of dentists in Canada's largest urban centre, Toronto, and explore whether distributional disparities are associated ... | 24,598,338 | D003815:Dentists; D040362:Geographic Information Systems; D006297:Health Services Accessibility; D054625:Healthcare Disparities; D006801:Humans; D007182:Income; D009864:Ontario; D014505:Urban Population | Journal (Canadian Dental Association) | 2,014 | ||
Risk factors for severe child discipline practices in rural India. | OBJECTIVES
To determine the type and severity of discipline practices in rural India and to identify risk and protective factors related to these practices.
METHODS
Five hundred mothers, ages 18-50, participated in face-to-face interviews as part of a cross-sectional, population-based survey. One of the mother's chil... | 10.1093/jpepsy/25.6.435 | 10,980,048 | D000293:Adolescent; D000328:Adult; D002648:Child; D002649:Child Abuse; D002668:Child Rearing; D003906:Developing Countries; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D009034:Mother-Child Relations; D010865:Pilot Projects; D012307:Risk Factors; D012424:Rural Population | Journal of pediatric psychology | 2,000 | |
A simple microplate assay for the determination of cellular protein. | In assays of leukocyte function it is desirable to correlate a specific measurement, e.g., the release of enzymes, the production of metabolites or the secretion of cytokines with the amount of cellular material. Many authors use either the protein or the DNA content of the cells as a reference. Specific measurements o... | 10.1016/0022-1759(85)90221-2 | 4,031,505 | D002460:Cell Line; D002470:Cell Survival; D004247:DNA; D005404:Fixatives; D006801:Humans; D007962:Leukocytes; D008213:Lymphocyte Activation; D014176:Protein Biosynthesis; D011506:Proteins; D012394:Rosaniline Dyes; D012995:Solubility; D014867:Water | Journal of immunological methods | 1,985 | D005404:Fixatives; D011506:Proteins; D012394:Rosaniline Dyes; D014867:Water; D004247:DNA; C004692:coomassie Brilliant Blue |
Root Colonization of Soybean Cultivars in the Field by Fusarium solani f. sp. glycines. | Soybean sudden death syndrome (SDS), caused by Fusarium solani f. sp. glycines, is a problem in some soybean-growing areas in the United States. Resistance is an important control strategy. In this study, root colonization of six soybean cultivars by F. solani f. sp. glycines was determined. Cultivars included suscepti... | 10.1094/PDIS.1999.83.12.1155 | 30,841,142 | Plant disease | 1,999 | ||
Clinical analysis of intracranial metastases in gestational choriocarcinoma: a series of 15 cases. | Between 1963 and 1980 we have had experience of 54 patients with gestational choriocarcinoma and 29 are alive, a survival rate of 53.7%. The disease had metastasized to the central nervous system in 15 of these 54 patients, an occurrence rate of cerebral metastases of 27.8%. 13 of these 15 patients have died and 2 are ... | 10.1111/j.1479-828x.1985.tb00595.x | 3,862,401 | D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001921:Brain; D001932:Brain Neoplasms; D002822:Choriocarcinoma; D006063:Chorionic Gonadotropin; D005260:Female; D006801:Humans; D011247:Pregnancy; D011379:Prognosis; D012306:Risk; D013997:Time Factors; D014594:Uterine Neoplasms | The Australian & New Zealand journal of obstetrics & gynaecology | 1,985 | D006063:Chorionic Gonadotropin |
Effects of ozone, ultraviolet and peracetic acid disinfection of a primary-treated municipal effluent on the immune system of rainbow trout (Oncorhynchus mykiss). | Municipal sewage effluents are complex mixtures that are known to compromise the health condition of aquatic organisms. The aim of this study was to evaluate the impacts of various wastewater disinfection processes on the immune system of juvenile rainbow trout (Oncorhynchus mykiss). The trout were exposed to a primary... | 10.1016/j.cbpc.2008.04.007 | 18,538,640 | D000818:Animals; D049628:Body Size; D049109:Cell Proliferation; D002947:Cities; D004202:Disinfectants; D004203:Disinfection; D007694:Killer Cells, Natural; D008213:Lymphocyte Activation; D008264:Macrophages; D017686:Oncorhynchus mykiss; D010126:Ozone; D010463:Peracetic Acid; D010587:Phagocytosis; D011792:Quebec; D01272... | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP | 2,008 | D004202:Disinfectants; D012722:Sewage; D010126:Ozone; D010463:Peracetic Acid |
Dynamic MDCT of the pancreas: is time-density curve morphology useful for the differential diagnosis of solid lesions? A preliminary report. | PURPOSE
CT perfusion has been proposed for pancreatic lesion characterization. However, scan and analysis protocols influence numerical data. To overcome this, the purpose of our study is to evaluate the use of time-density curves obtained from MDCT perfusion of the pancreas for the characterization of normal parenchym... | 10.1016/j.ejrad.2011.11.055 | 22,197,731 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell; D003287:Contrast Media; D003937:Diagnosis, Differential; D006801:Humans; D007472:Iohexol; D007680:Kidney Neoplasms; D008875:Middle Aged; D010182:Pancreatic Diseases; D011237:Predictive Value of Tests; D011857:Radiographic Image Inter... | European journal of radiology | 2,012 | D003287:Contrast Media; D007472:Iohexol; C038192:iopromide |
Living Donor Transplantation: Long-Term Evolution Related to Age Matching. | The lack of donors is favoring living kidney donor (LKD) transplantation worldwide, quite often beyond the classic age-matching rules. We analysed renal function (RF) at 1 and 5 years in all donor and recipients as well as death-censored graft and patient survival. LKD recipients were divided into 4 subgroups: young re... | 26,518,923 | D000328:Adult; D000367:Age Factors; D000368:Aged; D003404:Creatinine; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011507:Proteinuria; D012189:Retrospective Studies; D012307:Risk Factor... | Transplantation proceedings | 2,015 | D003404:Creatinine | |
Traumatic Posterior Atlanto-occipital Dislocation With Three-part Jefferson Fracture and Subaxial Distractive Extension Injury. | No previous reports have described combined upper and lower cervical injuries caused by a contrary injury mechanism. A 44-year-old man was transferred complaining of quadriplegia caused by a rear-end collision car accident. CT and MRI findings revealed posterior atlanto-occipital dislocation (AOD) with three-part Jeffe... | 10.5435/JAAOSGlobal-D-21-00070 | 34,270,464 | D000328:Adult; D006801:Humans; D004204:Joint Dislocations; D008279:Magnetic Resonance Imaging; D008297:Male; D019838:Neck Injuries; D016103:Spinal Fractures; D013124:Spinal Injuries | Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews | 2,021 | |
[Protective effect of Glycyrrhiza uralensis Fisch and its extracts on the chronic desensitization of beta-adrenoceptors in guinea pigs]. | Histamine-induced wheezing test is conjunction with radioligand binding assay showed that after long-term administration of isoprenaline the reactivity and R, value (total receptor binding sites) of beta-adrenoceptors in the lung tissue of guinea pigs were reduced. The decoction of Glycyrrhiza uralensis Fisch or its ex... | 1,664,726 | D000818:Animals; D001249:Asthma; D004351:Drug Resistance; D004365:Drugs, Chinese Herbal; D005260:Female; D006034:Glycyrrhetinic Acid; D006035:Glycyrrhiza; D006168:Guinea Pigs; D007545:Isoproterenol; D008297:Male; D010946:Plants, Medicinal; D011943:Receptors, Adrenergic, beta | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | 1,991 | D004365:Drugs, Chinese Herbal; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; D006034:Glycyrrhetinic Acid | |
Perceptual or motor learning in SRT tasks with complex sequence structures. | We investigated under which conditions sequence learning in a serial reaction time task can be based on perceptual learning. A replication of the study of Mayr (1996) confirmed perceptual and motor learning when sequences were learned concurrently. However, between-participants manipulations of the motor and perceptual... | 10.1007/s00426-004-0196-3 | 15,611,881 | D000328:Adult; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D009048:Motor Skills; D010465:Perception; D011930:Reaction Time | Psychological research | 2,006 | |
Glutamine supplementation prevents exercise-induced neutrophil apoptosis and reduces p38 MAPK and JNK phosphorylation and p53 and caspase 3 expression. | We have previously shown that a single session of exercise induces DNA fragmentation, mitochondrial membrane depolarization, increases expression of pro-apoptotic genes (bax and bcl-xS) and decreases expression of anti-apoptotic genes (bcl-xL) in rat neutrophils. Glutamine supplementation had a protective effect in the... | 10.1002/cbf.1421 | 17,542,038 | D000818:Animals; D017209:Apoptosis; D053148:Caspase 3; D019587:Dietary Supplements; D005973:Glutamine; D048031:JNK Mitogen-Activated Protein Kinases; D008297:Male; D009504:Neutrophils; D010766:Phosphorylation; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D016159:Tumor Suppressor Protein p5... | Cell biochemistry and function | 2,007 | D016159:Tumor Suppressor Protein p53; D005973:Glutamine; D048031:JNK Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D053148:Caspase 3 |
Analysis of Serotonin Molecules on Silver Nanocolloids-A Raman Computational and Experimental Study. | Combined theoretical and experimental analysis of serotonin by quantum chemical density functional calculations and surface-enhanced Raman spectroscopy, respectively, is presented in this work to better understand phenomena related to this neurotransmitter's detection and monitoring at very low concentrations specific ... | 10.3390/s17071471 | 28,640,186 | D000327:Adsorption; D003102:Colloids; D053768:Metal Nanoparticles; D012701:Serotonin; D012834:Silver; D013059:Spectrum Analysis, Raman | Sensors (Basel, Switzerland) | 2,017 | D003102:Colloids; D012701:Serotonin; D012834:Silver |
Association between increasing levels of hemoglobin A1c and coronary atherosclerosis in asymptomatic individuals without diabetes mellitus. | BACKGROUND
Earlier studies have shown an association between high-normal glucose and increasing glycosylated hemoglobin (HbA1c) levels and cardiovascular events. The objective of this investigation was to study the association between increasing levels of HbA1c in asymptomatic individuals without diabetes mellitus (DM)... | 10.1097/MCA.0b013e328337ff9b | 20,308,881 | D000328:Adult; D015415:Biomarkers; D001786:Blood Glucose; D002114:Calcinosis; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease; D003920:Diabetes Mellitus; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged... | Coronary artery disease | 2,010 | D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin A; C517652:hemoglobin A1c protein, human |
RNA-seq analysis and de novo transcriptome assembly of Jerusalem artichoke (Helianthus tuberosus Linne). | Jerusalem artichoke (Helianthus tuberosus L.) has long been cultivated as a vegetable and as a source of fructans (inulin) for pharmaceutical applications in diabetes and obesity prevention. However, transcriptomic and genomic data for Jerusalem artichoke remain scarce. In this study, Illumina RNA sequencing (RNA-Seq) ... | 10.1371/journal.pone.0111982 | 25,375,764 | D020869:Gene Expression Profiling; D018506:Gene Expression Regulation, Plant; D006368:Helianthus; D008969:Molecular Sequence Data; D009928:Organ Specificity; D018515:Plant Leaves; D010940:Plant Proteins; D018517:Plant Roots; D018547:Plant Stems; D017423:Sequence Analysis, RNA; D012689:Sequence Homology, Nucleic Acid | PloS one | 2,014 | D010940:Plant Proteins |
The role and significance of VEGFR2+ regulatory T cells in tumor immunity. | Tumor development is closely related to angiogenesis, and VEGFR2 plays an important role in tumor angiogenesis. It is broadly expressed in the blood vessels, especially in the microvessels of tumor tissues. Furthermore, VEGFR2 is detected on the surface of the cell membrane in various immune cells, such as dendritic ce... | 10.2147/OTT.S142085 | 28,919,780 | OncoTargets and therapy | 2,017 | ||
An assessment of factors associated with neurocognitive decline in people living with HIV. | Despite the widespread use of combination antiretroviral therapy (cART), HIV-associated neurocognitive impairment (NCI) remains a health concern. However, limited research has been done to identify factors associated with neurocognitive decline. We assessed risk factors associated with neurocognitive decline in people ... | 10.1177/09564624211043351 | 34,565,257 | D000203:Activities of Daily Living; D023241:Antiretroviral Therapy, Highly Active; D003865:Depressive Disorder, Major; D015658:HIV Infections; D006801:Humans; D009483:Neuropsychological Tests | International journal of STD & AIDS | 2,022 | |
[Bacterioplankton Communities and Assembly Mechanisms in Wet Season of Lakes, Nanchang]. | Bacterioplankton communities play an important role in nutrient cycling and organic matter decomposition in urban lakes. Based on high-throughput sequencing, we analyzed the temporal (April, June, and August) and urban-suburban difference and assembly of bacterioplankton communities in lakes of Nanchang City. Our resul... | 10.13227/j.hjkx.202203277 | 36,922,208 | D060106:Lakes; D012621:Seasons; D000458:Cyanobacteria; D010933:Plankton; D059001:Aquatic Organisms; D020560:Proteobacteria; D012336:RNA, Ribosomal, 16S; D017753:Ecosystem | Huan jing ke xue= Huanjing kexue | 2,023 | D012336:RNA, Ribosomal, 16S |
Long-term safety and tolerability of iloperidone: results from a 25-week, open-label extension trial. | INTRODUCTION/OBJECTIVE
Long-term use of the atypical antipsychotic iloperidone has not been investigated at doses above 16 mg/d. This article describes safety and tolerability results from the 25-week open-label extension of a 4-week placebo- and ziprasidone-controlled clinical trial of iloperidone.
METHODS
Patients ... | 10.1017/S1092852912000764 | 23,312,567 | D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D057915:Drug Substitution; D005260:Female; D006801:Humans; D007194:India; D007555:Isoxazoles; D008137:Longitudinal Studies; D008297:... | CNS spectrums | 2,013 | D014150:Antipsychotic Agents; D007555:Isoxazoles; D010879:Piperazines; D010880:Piperidines; D013844:Thiazoles; C092292:ziprasidone; C081732:iloperidone |
Visual detection of cyclobutane pyrimidine dimer DNA damage lesions by Hg2+ and carbon dots. | Cyclobutane pyrimidine dimmers (CPDs) and 6-4-[pyrimidine-2'-one] pyrimidine (6-4 PP) are major UV induced DNA damage lesions formed from solar radiation and other sources. CPD lesions are presumably mutagenic and carcinogenic that inhibit polymerases and interfere in DNA replication. An easy and cost effective way for... | 10.1016/j.aca.2018.02.029 | 29,534,804 | D002244:Carbon; D004247:DNA; D004249:DNA Damage; D008628:Mercury; D011740:Pyrimidine Dimers; D045663:Quantum Dots; D014466:Ultraviolet Rays | Analytica chimica acta | 2,018 | D011740:Pyrimidine Dimers; D002244:Carbon; D004247:DNA; D008628:Mercury |
Fundamental principles of cortical organization reflected in a new study. | In an exciting new finding by Gordon et al., the human motor cortex does not show a traditional body map. Instead, body-part-specific zones are separated by integrative zones, possibly reflecting the statistical structure of the human motor repertoire. | 10.1016/j.neuron.2023.04.024 | 37,141,890 | D006801:Humans; D009044:Motor Cortex; D001931:Brain Mapping | Neuron | 2,023 | |
Influence of far upstream element binding protein 1 gene on chemotherapy sensitivity in human U251 glioblastoma cells. | INTRODUCTION
The aim of this study was to determine the influence of the far upstream element binding protein 1 gene (FUBP1) on chemotherapy sensitivity in human U251 glioblastoma cells.
MATERIAL AND METHODS
Real-time polymerase chain reaction (PCR) was used to determine the expression of the FUBP1 gene in 43 cases o... | 10.5114/aoms.2016.57592 | 26,925,132 | Archives of medical science : AMS | 2,016 | ||
Novel metal based anti-tuberculosis agent: synthesis, characterization, catalytic and pharmacological activities of copper complexes. | Copper complexes of molecular formulae, [CuL(1)(OAc)], [CuL(2)(H(2)O)], [CuL(3)(H(2)O)], [CuL(4)(H(2)O)], [CuL(5)(H(2)O)] where L(1)-L(5) represents Schiff base ligands [by the condensation of 3-hydroxyflavone with 4-aminoantipyrine (L(1))/o-aminophenol (L(2))/o-aminobenzoic acid (L(3))/o-aminothiazole (L(4))/thiosemic... | 10.1016/j.ejmech.2012.01.006 | 22,321,994 | D000890:Anti-Infective Agents; D000975:Antioxidants; D000995:Antitubercular Agents; D001419:Bacteria; D001424:Bacterial Infections; D056831:Coordination Complexes; D003300:Copper; D053837:DNA Cleavage; D005419:Flavonoids; D005658:Fungi; D006801:Humans; D009161:Mycobacterium; D009181:Mycoses; D012545:Schiff Bases; D0143... | European journal of medicinal chemistry | 2,012 | D000890:Anti-Infective Agents; D000975:Antioxidants; D000995:Antitubercular Agents; D056831:Coordination Complexes; D005419:Flavonoids; D012545:Schiff Bases; D003300:Copper; C041477:3-hydroxyflavone |
Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation. | OBJECTIVE
Oxidant stress pathway activation during ischemia reperfusion injury may contribute to the development of primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidant stress gene variation in recipients and donors is associated with PGD.
METHODS
Donors and recipients from the Lun... | 25,439,478 | D000328:Adult; D004843:Epistasis, Genetic; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D005979:Glutathione Peroxidase; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D019255:NADPH Oxidases; D051267:NF-E2-Related Factor 2; D018384:Oxidative St... | The Journal of thoracic and cardiovascular surgery | 2,015 | D008565:Membrane Proteins; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D005979:Glutathione Peroxidase; D019255:NADPH Oxidases; C431570:Nox3 protein, human; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human | |
Internet Addiction and Academic Anxiety Among Chinese College Students During COVID-19: The Mediating Role of Psychological Contract. | Purpose
The objective of this study is to investigate the underlying mechanism connecting internet addiction and academic anxiety, with the aim of assisting higher education professionals and administrators in developing comprehensive solutions to effectively mitigate the systemic risks associated with these issues.
... | 10.2147/PRBM.S428599 | 37,810,276 | Psychology research and behavior management | 2,023 | ||
Slow-progressing photoreceptor cell degeneration in night blindness c mutant zebrafish. | We describe here the morphological and functional alterations of the retina of mutant zebrafish, night blindness c ( nbc ). The nbc mutant was isolated from the F1 generation of N -ethyl- N -nitrosourea mutagenized founders. Visual sensitivity of wildtype and heterozygous ( nbc (+/-)) mutant fish was determined using a... | 10.1023/B:NEUR.0000021905.33091.f1 | 15,044,842 | D000375:Aging; D000818:Animals; D002455:Cell Division; D015350:Contrast Sensitivity; D004195:Disease Models, Animal; D018450:Disease Progression; D005799:Genes, Dominant; D005804:Genes, Lethal; D006579:Heterozygote; D006720:Homozygote; D007814:Larva; D008854:Microscopy, Electron; D009154:Mutation; D009755:Night Blindne... | Journal of neurocytology | 2,003 | |
Hip Imaging in Athletes: Sports Imaging Series. | Hip or groin pain in athletes is common and clinical presentation is often nonspecific. Imaging is a very important diagnostic step in the work-up of athletes with hip pain. This review article provides an overview on hip biomechanics and discusses strategies for hip imaging modalities such as radiography, ultrasonogra... | 10.1148/radiol.2016151348 | 27,429,142 | D056352:Athletes; D001265:Athletic Injuries; D003952:Diagnostic Imaging; D006621:Hip Joint; D006801:Humans | Radiology | 2,016 | |
Spatiotemporal Patterns of Small for Gestational Age and Low Birth Weight Births and Associations With Land Use and Socioeconomic Status. | In addition to small for gestational age (SGA) and low birth weight at term (LBWT), critically ill cases of SGA/LBWT are significant events from outcomes and economic perspectives that require further understanding of risk factors. We aimed to assess the spatiotemporal distribution of locations where there were consist... | 10.1177/1178630219869922 | 31,488,949 | Environmental health insights | 2,019 | ||
Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization. | Methamphetamine (MA) is well known as a potent CNS stimulant, which produces strong rewarding and behavioral sensitization after repeated administration. In the present study, we investigated whether co-administration of dextromethorphan (DM) with MA could suppress these effects induced by acute and chronic MA treatmen... | 10.1007/s11373-006-9096-4 | 16,865,411 | D019969:Amphetamine-Related Disorders; D000818:Animals; D001522:Behavior, Animal; D000697:Central Nervous System Stimulants; D003915:Dextromethorphan; D004298:Dopamine; D018691:Excitatory Amino Acid Antagonists; D008297:Male; D008694:Methamphetamine; D009714:Nucleus Accumbens; D017397:Prefrontal Cortex; D051381:Rats; D... | Journal of biomedical science | 2,006 | D000697:Central Nervous System Stimulants; D018691:Excitatory Amino Acid Antagonists; D008694:Methamphetamine; D003915:Dextromethorphan; D004298:Dopamine |
Purification and biochemical characterization of a newly produced yellow laccase from Lentinus squarrosulus MR13. | A novel yellow laccase was produced from Lentinus squarrosulus MR13 under solid state fermentation. The yellow laccase was purified by a factor of 12.67-fold by ammonium sulfate precipitation, anion exchange chromatography and gel filtration chromatography to a specific activity of 3,772.86 IU mg-1. Its molecular mass ... | 10.1007/s13205-014-0219-8 | 28,324,287 | 3 Biotech | 2,015 | ||
Oversharing on Social Media: Anxiety, Attention-Seeking, and Social Media Addiction Predict the Breadth and Depth of Sharing. | Oversharing on social media by adolescents is a considerable problem in the digital age, and has the potential to instigate online shaming, cyberbullying, identity theft, and other security risks. To date, oversharing has not been comprehensively studied and there is scarce understanding of the possible psychological c... | 10.1177/00332941221122861 | 35,993,372 | Psychological reports | 2,022 | ||
Evaluation of the Efficiency of Random and Diblock Methacrylate-Based Amphiphilic Cationic Polymers against Major Bacterial Pathogens Associated with Cystic Fibrosis. | Cystic fibrosis (CF) is associated with repeated lung bacterial infection, mainly by Pseudomonas aeruginosa, Staphylococcus aureus, and Mycobacterium abscessus, all known to be or becoming resistant to several antibiotics, often leading to therapeutic failure and death. In this context, antimicrobial peptides and antim... | 10.3390/antibiotics12010120 | 36,671,321 | Antibiotics (Basel, Switzerland) | 2,023 | ||
Stents: an overview. | Over the last 10 years the development of stent technology has had a major effect on the treatment of patients with cardiac vascular and non-vascular disease. However, no two abnormalities are ever alike and stents differ hugely in their properties. | 10.12968/hosp.1999.60.8.1177 | 10,621,812 | D001672:Biocompatible Materials; D003252:Construction Materials; D006801:Humans; D015607:Stents | Hospital medicine (London, England : 1998) | 1,999 | D001672:Biocompatible Materials |
A colorimetric aptasensor for the highly sensitive detection of 8-hydroxy-2'-deoxyguanosine based on G-quadruplex-hemin DNAzyme. | A highly sensitive, low-cost colorimetric aptasensor was developed for the determination of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in human urine. The method is based on a conformational switching of the 8-OHdG aptamer to form a G-quadruplex structure in the presence of 8-OHdG. The resulting G-quadruplex assembles into a... | 24,811,738 | D000080242:8-Hydroxy-2'-Deoxyguanosine; D052157:Aptamers, Nucleotide; D052160:Benzothiazoles; D003124:Colorimetry; D021881:DNA, Catalytic; D003849:Deoxyguanosine; D054856:G-Quadruplexes; D006427:Hemin; D006801:Humans; D006861:Hydrogen Peroxide; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D013451:Su... | Analytical biochemistry | 2,014 | D052157:Aptamers, Nucleotide; D052160:Benzothiazoles; D021881:DNA, Catalytic; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D006427:Hemin; D000080242:8-Hydroxy-2'-Deoxyguanosine; D006861:Hydrogen Peroxide; D003849:Deoxyguanosine | |
Individual differences and the effect of face configuration information in the McGurk effect. | The McGurk effect, which denotes the influence of visual information on audiovisual speech perception, is less frequently observed in individuals with autism spectrum disorder (ASD) compared to those without it; the reason for this remains unclear. Several studies have suggested that facial configuration context might ... | 10.1007/s00221-018-5188-4 | 29,383,400 | D000328:Adult; D000067877:Autism Spectrum Disorder; D000066499:Facial Recognition; D005260:Female; D006801:Humans; D007088:Illusions; D007206:Individuality; D008297:Male; D011578:Psycholinguistics; D013067:Speech Perception; D055815:Young Adult | Experimental brain research | 2,018 | |
[Clinical characteristics of anomalous origin of the left coronary artery from the pulmonary artery in 91 children]. | Objective: To explore the clinical manifestations, diagnosis, treatment and prognosis of anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) . Methods: A retrospective study identified 91 patients diagnosed with ALCAPA at Shanghai Children's Medical Center from March 2010 to August 2017. Acc... | 10.3760/cma.j.issn.0578-1310.2019.08.009 | 31,352,747 | D000328:Adult; D063748:Bland White Garland Syndrome; D002303:Cardiac Output, Low; D006348:Cardiac Surgical Procedures; D002648:Child; D002681:China; D003330:Coronary Vessel Anomalies; D004562:Electrocardiography; D006801:Humans; D007223:Infant; D008944:Mitral Valve Insufficiency; D019990:Perioperative Care; D011651:Pul... | Zhonghua er ke za zhi = Chinese journal of pediatrics | 2,019 | |
Classical Paroxysmal Nocturnal Hemoglobinuria Presenting With Severe Anemia and Pigmented Acute Kidney Injury. | Paroxysmal nocturnal hemoglobinuria is a rare form of intravascular hemolysis caused by an acquired deficiency of complement regulatory glycoproteins. In our case, a 53-year-old male presented with fatigue, discoloration of urine, and reduced urine output. Preliminary investigations showed severe anemia (3.7 g/dl) and ... | 10.7759/cureus.28448 | 36,046,061 | Cureus | 2,022 | ||
Environmental assessment of utilizing date palm ash as partial replacement of cement in mortar. | Saudi Arabia's date palm industry generates date palm ash (DPA) from the thermal processing of palm oil fibers and shells. This waste material has potential to be used as partial replacement of cement in structural mortar. However, no studies to date have examined its pollution potential. DPA was used as a cement repla... | 10.1016/j.jhazmat.2018.06.013 | 29,886,362 | Journal of hazardous materials | 2,018 | ||
Moderate and severe traumatic brain injury induce early overexpression of systemic and brain gelatinases. | OBJECTIVE
Recent experimental evidence suggests that matrix metalloproteinases (MMPs) are implicated in the pathophysiology of traumatic brain injury (TBI) by increasing blood-brain barrier permeability and exacerbating posttraumatic edema. We examined the acute profile of MMP-2 and MMP-9 in the plasma of patients with... | 10.1007/s00134-008-1056-1 | 18,350,273 | D000328:Adult; D001812:Blood-Brain Barrier; D001930:Brain Injuries; D045604:Extracellular Fluid; D005260:Female; D018093:Gelatinases; D015600:Glasgow Coma Scale; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D017551:Microdialysis; D0... | Intensive care medicine | 2,008 | D018093:Gelatinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9 |
Lanostane Triterpenes from Gloeophyllum odoratum and Their Anti-Influenza Effects. | In an in vitro screening for anti-influenza agents from European polypores, the fruit body extract of Gloeophyllum odoratum dose-dependently inhibited the cytopathic effect of the H3N2 influenza virus A/Hong Kong/68 (HK/68) in Madin Darby canine kidney cells with a 50% inhibitory concentration (IC50) of 15 µg/mL, a non... | 10.1055/a-0690-9236 | 30,130,818 | D000818:Animals; D000998:Antiviral Agents; D001487:Basidiomycota; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D020128:Inhibitory Concentration 50; D061985:Madin Darby Canine Kidney Cells; D009682:Magnetic Resonance Spectroscop... | Planta medica | 2,019 | D000998:Antiviral Agents; D014315:Triterpenes |
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels. | Optically active mexiletine analogues were synthesized and evaluated in vitro as use-dependent blockers of skeletal muscle sodium channels. The mexiletine analogues were obtained by replacing either the methyl group on the stereogenic center of mexiletine [1-(2,6-dimethylphenoxy)propan-2-amine] with a phenyl group or m... | 10.1021/jm030865y | 14,613,326 | D000818:Animals; D066298:In Vitro Techniques; D015640:Ion Channel Gating; D008801:Mexiletine; D018485:Muscle Fibers, Skeletal; D018482:Muscle, Skeletal; D018408:Patch-Clamp Techniques; D010627:Phenethylamines; D010647:Phenyl Ethers; D011893:Rana esculenta; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D0132... | Journal of medicinal chemistry | 2,003 | C479891:2-(2-methylphenoxy)-1-phenylethanamine; D010627:Phenethylamines; D010647:Phenyl Ethers; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D008801:Mexiletine |
Exploring the intersection of neighborhood racial and economic composition and individual race on substance use among male adolescents. | This article examines how Blacks and Whites living in neighborhoods with divergent racial and income profiles differed in early onset (by age 14 years) and adolescent lifetime prevalence (by age 18 years) of substance use, with longitudinal data from 473 high-risk boys (58% Black). A latent profile analysis identified ... | 10.1080/15332640.2012.652526 | 22,381,123 | D000293:Adolescent; D017668:Age of Onset; D044383:Black People; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008385:Marijuana Smoking; D015995:Prevalence; D012111:Residence Characteristics; D012907:Smoking; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders; D044465:White People | Journal of ethnicity in substance abuse | 2,012 | |
[Clinical characteristics and genetic analysis of a child with infantile Sandhoff disease and eosinophilia]. | OBJECTIVE
To explore the genetic basis for a girl featuring epilepsy, developmental delay and regression.
METHODS
Clinical data of the patient was collected. Activities of hexosaminidase A (Hex A) and hexosaminidase A&B (Hex A&B) in blood leukocytes were determined by using a fluorometric assay. Peripheral blood samp... | 10.3760/cma.j.cn511374-20211022-00843 | 36,184,097 | D002648:Child; D004802:Eosinophilia; D005260:Female; D005820:Genetic Testing; D054818:Hexosaminidase A; D054819:Hexosaminidase B; D006801:Humans; D008297:Male; D009154:Mutation; D010375:Pedigree; D012497:Sandhoff Disease | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics | 2,022 | D054818:Hexosaminidase A; D054819:Hexosaminidase B |
Low-dose ciclosporin, prednisone, and azathioprine after initial immunosuppression with ciclosporin and prednisone in a pediatric renal transplant population. | The use of a triple therapy regimen after initial immunosuppression with prednisone and ciclosporin in the pediatric age groups has not been described. Twenty-two patients were switched to low-dose ciclosporin, prednisone, and azathioprine due to toxicity, noncompliance, and long-term ciclosporin treatment. The acute r... | 2,285,916 | D000206:Actuarial Analysis; D001379:Azathioprine; D002648:Child; D003524:Cyclosporins; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents; D016030:Kidney Transplantation; D008297:Male; D011241:Pr... | Child nephrology and urology | 1,990 | D003524:Cyclosporins; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone | |
Field observations on the variability of crude oil impact on indigenous hydrocarbon-degrading bacteria from sub-Antarctic intertidal sediments. | Oil pollution of the oceans has been a problem ever since man began to use fossil fuels. Biodegradation by naturally occurring populations of micro-organisms is a major mechanism for the removal of petroleum from the environment. To examine the effects of crude oil pollution on intertidal bacteria, we repeated the same... | 10.1016/s0141-1136(99)00080-x | 11,285,720 | D000864:Antarctic Regions; D001673:Biodegradation, Environmental; D019015:Geologic Sediments; D006838:Hydrocarbons; D010578:Petroleum | Marine environmental research | 2,000 | D006838:Hydrocarbons; D010578:Petroleum |
Pain-related distress and interference with daily life of ambulatory patients with cancer with pain. | PURPOSE/OBJECTIVES
To examine the unique and combined effects of pain intensity, pain-related distress, analgesic prescription, and negative mood on interference with daily life because of pain.
DESIGN
Descriptive, cross-sectional.
SETTING
Two cancer clinics in academic medical centers in the southeastern United St... | 10.1188/03.ONF.977-986 | 14,603,355 | D000203:Activities of Daily Living; D000700:Analgesics; D003430:Cross-Sectional Studies; D006801:Humans; D009369:Neoplasms; D010146:Pain; D011788:Quality of Life; D012044:Regression Analysis; D015144:Southeastern United States | Oncology nursing forum | 2,003 | D000700:Analgesics |
Factors predicting the feasibility of monitoring lower-limb muscle motor evoked potentials in patients undergoing excision of spinal cord tumors. | OBJECT
This prospective study on intraoperative muscle motor evoked potentials (MMEPs) from lower-limb muscles in patients undergoing surgery for spinal cord tumors was performed to: 1) determine preoperative clinical features that could predict successful recording of lower-limb MMEPs; 2) determine the muscle in the l... | 10.3171/2011.1.SPINE10310 | 21,438,657 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004558:Electric Stimulation; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D018482:Muscle, Skeletal; D011446:Prospective Studies; D013120:S... | Journal of neurosurgery. Spine | 2,011 | |
Bladder neck resection and transurethral resection of the prostate: a randomized prospective trial. | Transurethral resection of the prostate and bladder neck incision are accepted methods in the treatment of obstructive prostatic hyperplasia. Bladder neck incision is particularly useful in cases of small prostates. We have modified the method of bladder neck incision to bladder neck resection. A randomized prospective... | 10.1016/s0022-5347(17)43381-7 | 2,443,727 | D000368:Aged; D002986:Clinical Trials as Topic; D006801:Humans; D007902:Length of Stay; D008297:Male; D008722:Methods; D011183:Postoperative Complications; D011446:Prospective Studies; D011468:Prostatectomy; D011470:Prostatic Hyperplasia; D011897:Random Allocation; D001743:Urinary Bladder | The Journal of urology | 1,987 | |
Cloning and expression of two related connexins from the perch retina define a distinct subgroup of the connexin family. | We have cloned cDNAs for two closely related connexins (Cx), Cx35 and Cx34.7, from a perch retinal cDNA library. Sequencing of PCR products from genomic DNA revealed that both connexins have an intron 71 bp after the translation initiation site; in Cx35, the intron is 900 bp in length, whereas in Cx34.7 it is approxima... | 9,742,134 | D000818:Animals; D016375:Antisense Elements (Genetics); D001492:Bass; D015152:Blotting, Northern; D015139:Blotting, Southern; D001923:Brain Chemistry; D002450:Cell Communication; D003001:Cloning, Molecular; D017630:Connexins; D019143:Evolution, Molecular; D005136:Eye Proteins; D029941:Fish Proteins; D017629:Gap Junctio... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 1,998 | D016375:Antisense Elements (Genetics); D017630:Connexins; D005136:Eye Proteins; D029941:Fish Proteins; D012333:RNA, Messenger; C114667:connexin 34.7 protein, Morone americana; C100585:connexin 35 protein, vertebrate | |
New silicon substituted BiMeVO : synthesis and study of structural properties in relation to ionic conductivity. | Partial substitution of vanadium with silicon in the compound Bi4V2O11, which belongs to the Aurivillius family, leads to the creation of a solid solution Bi4V2- Si O11- (0 ≤ x ≤ 0.4). The compound with x = 0.1 turns out to be a monoclinic α-form of Bi4V2O11, while the compounds with x = 0.2 and x = 0.3 are orthorhomb... | 10.1039/d3ra00485f | 36,909,757 | RSC advances | 2,023 | ||
Antimicrobial stewardship program in a Greek hospital: implementing a mandatory prescription form and prospective audits. | AIM
Antimicrobial stewardship programs (ASPs) are urgently needed for Greek hospitals in order to improve antibiotic usage.
PATIENTS & METHODS
An ASP was implemented to a Greek hospital since February 2014. A mandatory order form was introduced for five antimicrobials; colistin, tigecycline, daptomycin, doripenem and... | 10.2217/fmb-2018-0020 | 29,661,029 | D000900:Anti-Bacterial Agents; D000073602:Antimicrobial Stewardship; D001424:Bacterial Infections; D006115:Greece; D006761:Hospitals; D006801:Humans; D055656:Prescriptions; D015397:Program Evaluation; D011446:Prospective Studies | Future microbiology | 2,018 | D000900:Anti-Bacterial Agents |
Investigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors. | Investigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors. Groups of rats were treated orally for four weeks with either dibenzepin, lithiumcarbon... | 10.1007/BF00501432 | 6,148,707 | D000818:Animals; D003984:Dibenzazepines; D004873:Ergolines; D005625:Frontal Lobe; D008094:Lithium; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011985:Receptors, Serotonin; D013997:Time Factors | Naunyn-Schmiedeberg's archives of pharmacology | 1,984 | D003984:Dibenzazepines; D004873:Ergolines; D011985:Receptors, Serotonin; D008094:Lithium; C031649:mesulergine |
Major circadian variations of glucose homeostasis in a patient with Rabson-Mendenhall syndrome and primary insulin resistance due to a mutation (Cys284-->Tyr) in the insulin receptor alpha-subunit. | We have performed clinical, in vitro biochemical, and genetic studies of a patient with severe insulin resistance, considerable growth restriction, and Rabson-Mendenhall syndrome (patient RM-3). The blood IGF-I level was undetectable in this patient, although the GH level was moderately decreased. During the postprandi... | 10.1203/00006450-199707000-00012 | 9,212,040 | D000595:Amino Acid Sequence; D001483:Base Sequence; D001786:Blood Glucose; D002648:Child; D002940:Circadian Rhythm; D004252:DNA Mutational Analysis; D002658:Developmental Disabilities; D005947:Glucose; D006706:Homeostasis; D019382:Human Growth Hormone; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin; D0073... | Pediatric research | 1,997 | D001786:Blood Glucose; D007328:Insulin; D018969:Insulin-Like Growth Factor Binding Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin; D005947:Glucose |
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