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Nervous system function during exercise in hypoxia. | Aerobic exercise capacity decreases with exposure to hypoxia. This article focuses on the effects of hypoxia on nervous system function and the potential consequences for the exercising human. Emphasis is put on somatosensory muscle afferents due to their crucial role in the reflex inhibition of muscle activation and i... | 10.1089/ham.2008.1105 | 19,555,297 | D001794:Blood Pressure; D001921:Brain; D002540:Cerebral Cortex; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D000860:Hypoxia; D009119:Muscle Contraction; D018763:Muscle Fatigue; D018485:Muscle Fibers, Skeletal; D018482:Muscle, Skeletal; D009424:Nervous System Physiological Phenomena; D009474:Neurons; D018377:N... | High altitude medicine & biology | 2,009 | D018377:Neurotransmitter Agents; D010100:Oxygen |
An intronic mutation in Chd7 creates a cryptic splice site, causing aberrant splicing in a mouse model of CHARGE syndrome. | Alternate splicing is a critical regulator of gene expression in eukaryotes, however genetic mutations can cause erroneous splicing and disease. Most recorded splicing disorders are caused by mutations of splice donor/acceptor sites, however intronic mutations can affect splicing. Clinical exome analyses largely ignore... | 10.1038/s41598-018-23856-8 | 29,615,807 | D000818:Animals; D001483:Base Sequence; D058747:CHARGE Syndrome; D004268:DNA-Binding Proteins; D004195:Disease Models, Animal; D006309:Hearing; D007438:Introns; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D010641:Phenotype; D022821:RNA Splice Sites; D012326:RNA Splicing | Scientific reports | 2,018 | C507367:Chd7 protein, mouse; D004268:DNA-Binding Proteins; D022821:RNA Splice Sites |
[Design and application of special solid phase extraction column for three cannabinol compounds in hemp]. | Cannabidiol (CBD), cannabinol (CBN), and Δ9-tetrahydrocannabinol (THC) are the most important components of hemp, whose concentrations determine the properties and applications of hemp. Hemp contains a large number of impurities, which must be removed from the extracting solution before determining the cannabinol conte... | 10.3724/SP.J.1123.2020.09025 | 34,227,338 | D002185:Cannabidiol; D002187:Cannabinol; D002188:Cannabis; D013759:Dronabinol; D052616:Solid Phase Extraction | Se pu = Chinese journal of chromatography | 2,021 | D002185:Cannabidiol; D013759:Dronabinol; D002187:Cannabinol |
The incidence and the risk factors of venous thromboembolism in Korean patients with pelvic or acetabular fractures. | BACKGROUND
Pelvic ring and acetabular fractures are the results of high energy trauma, but there is a paucity of information available regarding the incidence and risk factors of venous thromboembolism (VTE) after these injuries in Asians. This study was undertaken to evaluate the incidence of VTE after a pelvic or an ... | 10.1007/s00776-014-0553-z | 24,627,176 | D000077:Acetabulum; D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants; D003287:Contrast Media; D005260:Female; D050723:Fractures, Bone; D006801:Humans; D015994:Incidence; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D010384:Pelvic Bones; D010690:Phlebography; D011446:Prospecti... | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association | 2,014 | D000925:Anticoagulants; D003287:Contrast Media |
CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome. | Chimeric antigen receptor (CAR) T cell expansion and persistence represent key factors to achieve complete responses and prevent relapses. These features are typical of early memory T cells, which can be highly enriched through optimized manufacturing protocols. Here, we investigated the efficacy and safety profiles of... | 35,503,659 | D000818:Animals; D000080424:Cytokine Release Syndrome; D016219:Immunotherapy, Adoptive; D019409:Interleukin-15; D000091246:Memory T Cells; D051379:Mice; D011948:Receptors, Antigen, T-Cell; D000076962:Receptors, Chimeric Antigen | The Journal of clinical investigation | 2,022 | D019409:Interleukin-15; D011948:Receptors, Antigen, T-Cell; D000076962:Receptors, Chimeric Antigen | |
Gastrointestinal stromal tumors: CT and MRI findings. | The objective of this study was to report the CT and MRI appearances of primary and metastatic gastrointestinal stromal tumor (GIST). The clinical and imaging findings of 31 patients with histological and immunohistochemical diagnosis of GIST were reviewed. The CT and MRI findings were assessed independently for size, ... | 10.1007/s00330-005-2647-7 | 15,761,716 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents; D001549:Benzamides; D004379:Duodenal Neoplasms; D005260:Female; D046152:Gastrointestinal Stromal Tumors; D006801:Humans; D007089:Image Enhancement; D000068877:Imatinib Mesylate; D007421:Intestine, Small; D008113:Liver Neoplasms; D008... | European radiology | 2,005 | D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases |
'We've had enough of experts': the enduring charm of quackery. | Broadcaster and journalist. FRCP (hon). | 10.1192/bjp.2018.64 | 29,693,538 | D006801:Humans; D008511:Medicine; D011781:Quackery; D012586:Science; D013850:Thinking | The British journal of psychiatry : the journal of mental science | 2,018 | |
Image-guided thermal ablation of nonresectable hepatic tumors using the Cool-Tip radiofrequency ablation system. | Percutaneous thermal ablation techniques have gained considerable attention as an alternative to surgery for the treatment of malignant liver tumors in selected patients. In particular, image-guided radiofrequency ablation (RFA) is increasingly being used for the local treatment of hepatocellular carcinoma, as well as ... | 10.1586/17434440.4.6.803 | 18,035,946 | D017115:Catheter Ablation; D015179:Colorectal Neoplasms; D004566:Electrodes; D006801:Humans; D008113:Liver Neoplasms; D011846:Radio Waves; D013696:Temperature; D013813:Therapy, Computer-Assisted | Expert review of medical devices | 2,007 | |
Significance of the lacunar hydration pattern after corneal cross linking. | PURPOSE
The aim of the present study was to investigate the characteristic honeycomb hydration pattern after corneal cross linking using in vivo rabbit cornea.
METHODS
After removal of the central epithelium, the right corneas of 4 New Zealand white rabbits were cross-linked applying a photosensitizing 0.1% riboflavi... | 10.1097/ICO.0b013e3181ca3293 | 20,508,511 | D000818:Animals; D001834:Body Water; D003094:Collagen; D015715:Corneal Edema; D003319:Corneal Stroma; D003432:Cross-Linking Reagents; D003646:Debridement; D004547:Elastic Tissue; D005260:Female; D005486:Flavin Mononucleotide; D017319:Photosensitizing Agents; D011817:Rabbits; D014466:Ultraviolet Rays; D014945:Wound Heal... | Cornea | 2,010 | D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D005486:Flavin Mononucleotide; D003094:Collagen |
Association of myosin I alpha with endosomes and lysosomes in mammalian cells. | Myosin Is, which constitute a ubiquitous monomeric subclass of myosins with actin-based motor properties, are associated with plasma membrane and intracellular vesicles. Myosin Is have been proposed as key players for membrane trafficking in endocytosis or exocytosis. In the present paper we provide biochemical and imm... | 10.1091/mbc.10.5.1477 | 10,233,157 | D000199:Actins; D000818:Animals; D001667:Binding, Competitive; D001692:Biological Transport; D006528:Carcinoma, Hepatocellular; D002451:Cell Compartmentation; D002478:Cells, Cultured; D003599:Cytoskeleton; D004705:Endocytosis; D011992:Endosomes; D007150:Immunohistochemistry; D007425:Intracellular Membranes; D008114:Liv... | Molecular biology of the cell | 1,999 | D000199:Actins; D011990:Receptors, Transferrin; D009218:Myosins |
Randomized double-blind comparison of lidocaine gel and plain lubricating gel in relieving pain during flexible cystoscopy. | PURPOSE
To compare the pain induced by outpatient flexible cystoscopy in men having local lidocaine jelly application or plain lubricant.
PATIENTS AND METHODS
We performed a randomized, double-blind study to compare the anesthetic effect of intraurethral 2% lidocaine gel (N = 45) and plain lubricant (N = 46) in men u... | 10.1089/end.2005.19.163 | 15,798,411 | D000368:Aged; D000553:Ambulatory Care; D000779:Anesthetics, Local; D000891:Anti-Infective Agents, Local; D002710:Chlorhexidine; D003558:Cystoscopy; D004311:Double-Blind Method; D005782:Gels; D006801:Humans; D008012:Lidocaine; D008153:Lubrication; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Car... | Journal of endourology | 2,005 | D000779:Anesthetics, Local; D000891:Anti-Infective Agents, Local; D005782:Gels; D008012:Lidocaine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine |
Application of shelf life decision system (SLDS) to marine cultured fish quality. | Growth of natural microflora of marine cultured, air-packed, sea bass (Dichentrachus labrax) was studied at isothermal conditions in the 0-15 degrees C range and kinetically modelled using the four-parameter Logistic equation. Sensory shelf life was correlated to pseudomonad population and sensory acceptability was cor... | 10.1016/s0168-1605(01)00659-6 | 11,934,045 | D000818:Animals; D017756:Aquaculture; D015169:Colony Count, Microbial; D005399:Fishes; D005516:Food Microbiology; D005519:Food Preservation; D008954:Models, Biological; D011786:Quality Control; D017747:Seafood; D013649:Taste; D013696:Temperature | International journal of food microbiology | 2,002 | |
Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template. | The DNA genome of a hepatitis B virus is generated by reverse transcription of the RNA pregenome. Replication initiation does not involve a nucleic acid primer; instead, the hepadnavirus P protein binds to the structured RNA encapsidation signal epsilon, from which it copies a short DNA primer that becomes covalently l... | 10.1128/MCB.18.11.6265 | 9,774,643 | D001483:Base Sequence; D004261:DNA Replication; D015684:Gene Products, pol; D015611:Hepatitis B Virus, Duck; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D012194:RNA-Directed DNA Polymerase; D012261:Ribonucleoproteins; D014764:Vi... | Molecular and cellular biology | 1,998 | D015684:Gene Products, pol; C066027:P protein, Hepatitis B virus; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; D014764:Viral Proteins; D012194:RNA-Directed DNA Polymerase |
Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries. | AIMS
Aging is a major risk factor for carotid artery disease and stroke. Endothelin-1 (ET-1) and angiotensin II (Ang II) are important modifiers of vascular disease, partly through increased activity of NADPH oxidase and vasoconstrictor prostanoids. Since the renin-angiotensin and endothelin systems become activated wi... | 24,607,776 | D000375:Aging; D000804:Angiotensin II; D000818:Animals; D019540:Area Under Curve; D017536:Carotid Artery, Common; D019332:Endothelin-1; D005786:Gene Expression Regulation; D066298:In Vitro Techniques; D008297:Male; D008810:Mice, Inbred C57BL; D019255:NADPH Oxidases; D017466:Receptors, Endothelin; D017482:Receptors, Thr... | Life sciences | 2,014 | D019332:Endothelin-1; D017466:Receptors, Endothelin; D017482:Receptors, Thromboxane; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D019255:NADPH Oxidases | |
Long-Term Outcomes of Renal Function After Adult Intestinal Transplantation at a Single Small-Volume Center: 2 Cases of Renal Transplantation. | PURPOSE
Renal dysfunction more frequently occurs after intestinal transplantation (ITx) than after heart, lung, or liver transplantation. We provide a clinical analysis of renal function after adult ITx.
METHODS
We retrospectively analyzed 8 adult ITx patients who survived for at least 6 months between 2004 and 2018.... | 10.1016/j.transproceed.2019.01.124 | 31,056,248 | D000328:Adult; D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007422:Intestines; D007668:Kidney; D007674:Kidney Diseases; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult | Transplantation proceedings | 2,019 | |
Trends in oxygenate/hydrocarbon selectivity for electrochemical CO(2) reduction to C2 products. | The electrochemical conversion of carbon di-/monoxide into commodity chemicals paves a way towards a sustainable society but it also presents one of the great challenges in catalysis. Herein, we present the trends in selectivity towards specific dicarbon oxygenate/hydrocarbon products from carbon monoxide reduction on ... | 10.1038/s41467-022-29140-8 | 35,302,055 | Nature communications | 2,022 | ||
Spatiotemporal distribution characteristics of potentially toxic elements in agricultural soils across China and associated health risks and driving mechanism. | Comprehensive analysis of spatiotemporal distribution characteristics of potentially toxic elements (PTEs) in soils of China, and associated driving mechanism and health risks is crucial for soil pollution prevention and risk control. In this study, a total of 8 PTEs in agricultural soils of 236 city case data from 31 ... | 10.1016/j.scitotenv.2023.163897 | 37,172,833 | D006801:Humans; D012987:Soil; D019216:Metals, Heavy; D004784:Environmental Monitoring; D002104:Cadmium; D007854:Lead; D012989:Soil Pollutants; D018570:Risk Assessment; D008628:Mercury; D002681:China | The Science of the total environment | 2,023 | D012987:Soil; D019216:Metals, Heavy; D002104:Cadmium; D007854:Lead; D012989:Soil Pollutants; D008628:Mercury |
Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects. | PURPOSE
High sodium intake is an accepted risk factor for hypertension, while low Na+ intake has also been associated with increased risk of cardiovascular events. In this cross-sectional study, we examined the association of 24-h urinary Na+ excretion with haemodynamics and volume status.
MATERIALS AND METHODS
Haemo... | 10.1080/08037051.2023.2170869 | 36,708,156 | D008297:Male; D005260:Female; D006801:Humans; D000328:Adult; D001794:Blood Pressure; D014867:Water; D003430:Cross-Sectional Studies; D063177:Pulse Wave Analysis; D006973:Hypertension; D012964:Sodium; D006929:Hyperaldosteronism | Blood pressure | 2,023 | D014867:Water; D012964:Sodium |
Tracking the growth fate of single cells and isolating slow-growing cells in human colorectal cancer organoids. | Patient-derived tumor organoids are three-dimensionally cultured cancer cells that enable a suitable platform for studying heterogeneity and plasticity of cancer. We present a protocol for tracking the growth fate of single cells and isolating slow-growing cells in human colorectal cancer organoids. We describe steps f... | 10.1016/j.xpro.2023.102395 | 37,384,521 | STAR protocols | 2,023 | ||
Delayed cerebrospinal-fluid shunt infection in children. | Twelve patients with shunt infection occurring more than 6 months following shunt implantation or revision were identified and their charts reviewed. These cases were accumulated over a 9-year period, and delays from shunt surgery to detection were as long as 11 years. For 5 patients, no antecedent infection or surgery... | 10.1159/000120458 | 2,702,349 | D000293:Adolescent; D001419:Bacteria; D001424:Bacterial Infections; D018407:Bacterial Physiological Phenomena; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D005260:Female; D006325:Heart Atria; D006801:Humans; D007223:Infant; D008297:Male; D009657:North Carolina; D010537:Peritoneum; D011183:Postoperative Complicat... | Pediatric neuroscience | 1,989 | |
Effect of Mucin and Bicarbonate Ion on Corrosion Behavior of AZ31 Magnesium Alloy for Airway Stents. | The biodegradable ability of magnesium alloys is an attractive feature for tracheal stents since they can be absorbed by the body through gradual degradation after healing of the airway structure, which can reduce the risk of inflammation caused by long-term implantation and prevent the repetitive surgery for removal o... | 10.3390/ma7085866 | 28,788,166 | Materials (Basel, Switzerland) | 2,014 | ||
Changing epidemiology, diagnosis, and treatment of Clostridium difficile toxin-associated colitis. | One hundred and ninety patients with Clostridium difficile toxin-associated colitis (CTAC) or pseudomembranous colitis (PMC) were identified, from microbiology records, disease index and proctoscopy service records, and studied retrospectively. CTAC was associated with cephalosporin antibiotic administration in 70 per ... | 10.1002/bjs.1800730614 | 3,719,271 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents; D001414:Bacitracin; D001427:Bacterial Toxins; D002648:Child; D002675:Child, Preschool; D003013:Clostridium; D004761:Enterocolitis, Pseudomembranous; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008795:Metronidazole; D00887... | The British journal of surgery | 1,986 | D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D001414:Bacitracin; D008795:Metronidazole; D014640:Vancomycin |
Evaluation of the effectiveness of a structured breast-feeding promotion program integrated into a Maternal and Child Health service in Jerusalem. | A community program for promotion of breast-feeding integrated into the Maternal and Child Health (MCH) services is presented and evaluated, using two quasi-experimental designs, comparison groups and time trends. The program, which began in 1981, included guidance from the 7th month of pregnancy to 6 months post-deliv... | 3,403,232 | D001942:Breast Feeding; D002662:Child Health Services; D003153:Community Health Services; D004493:Education; D004651:Employment; D005260:Female; D006293:Health Promotion; D006801:Humans; D007223:Infant; D007225:Infant Food; D007231:Infant, Newborn; D008427:Maternal Health Services; D009313:National Health Programs; D01... | Israel journal of medical sciences | 1,988 | ||
Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date. | Previous reports have described the appearance of systemic lupus erythematosus (SLE) cases following interferon-α (IFN-α) therapy, IFN-regulated gene expression is significantly increased in SLE, and an association between SLE and gene variants belonging to IFN downstream pathways has been shown. Based on this, targeti... | 10.2147/DDDT.S170969 | 31,190,735 | D000818:Animals; D061067:Antibodies, Monoclonal, Humanized; D006801:Humans; D008180:Lupus Erythematosus, Systemic | Drug design, development and therapy | 2,019 | D061067:Antibodies, Monoclonal, Humanized; C582345:anifrolumab |
A comparison of mobility assessments in a geriatric day hospital. | OBJECTIVE
To assess the sensitivity of the Elderly Mobility Scale (EMS) to detect improvements in mobility after physiotherapy in comparison with the Barthel Index (BI) and Functional Ambulation Category (FAC) in routine clinical day hospital practice.
SUBJECTS
Eighty-three patients who completed a course of physioth... | 10.1191/026921501675281708 | 11,386,400 | D000368:Aged; D000553:Ambulatory Care; D005081:Exercise Therapy; D005260:Female; D005853:Geriatrics; D006761:Hospitals; D006801:Humans; D008124:Locomotion; D008297:Male; D017063:Outcome Assessment, Health Care; D012680:Sensitivity and Specificity | Clinical rehabilitation | 2,001 | |
[A rheumatologic syndrome (paraneoplastic?) in benign tumors]. | The authors discuss the possible development of rheumatoid paraneoplastic syndrome in patients with benign tumours. They present three observations they made (cardiac myxoma, subpleural lipoma and pulmonary fibrosclerotic pseudotumour). Paraneoplasias in these cases are interesting from the pathogenetic aspect as regar... | 9,601,871 | D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes; D012216:Rheumatic Diseases | Vnitrni lekarstvi | 1,997 | ||
Simvastatin releases Ca2+ from a thapsigargin-sensitive pool and inhibits InsP3-dependent Ca2+ mobilization in vascular smooth muscle cells. | Simvastatin (SV), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity inhibits migration and proliferation of vascular smooth muscle cells (SMC). To investigate whether these effects of SV are related to inhibition of cell calcium mobilization, cultured SMC obtained from rat aorta were lo... | 10.1097/00005344-199603000-00011 | 8,907,800 | D000804:Angiotensin II; D000818:Animals; D002118:Calcium; D000252:Calcium-Transporting ATPases; D002478:Cells, Cultured; D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D015544:Inositol 1,4,5-Trisphosphate; D008148:Lovastatin; D009131:Muscle, Smooth, Vascular; D051381:Rats; D019821:Si... | Journal of cardiovascular pharmacology | 1,996 | D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000804:Angiotensin II; D019284:Thapsigargin; D015544:Inositol 1,4,5-Trisphosphate; D008148:Lovastatin; D019821:Simvastatin; D000252:Calcium-Transporting ATPases; D002118:Calcium |
Genetic origins of lactase persistence and the spread of pastoralism in Africa. | In humans, the ability to digest lactose, the sugar in milk, declines after weaning because of decreasing levels of the enzyme lactase-phlorizin hydrolase, encoded by LCT. However, some individuals maintain high enzyme amounts and are able to digest lactose into adulthood (i.e., they have the lactase-persistence [LP] t... | 24,630,847 | D000349:Africa; D006801:Humans; D007438:Introns; D043322:Lactase; D010694:Lactase-Phlorizin Hydrolase; D018895:Microsatellite Repeats; D064151:Minichromosome Maintenance Complex Component 6; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic | American journal of human genetics | 2,014 | D043322:Lactase; D010694:Lactase-Phlorizin Hydrolase; C103258:MCM6 protein, human; D064151:Minichromosome Maintenance Complex Component 6 | |
Assembly and enlargement of the primary cell wall in plants. | Growing plant cells are shaped by an extensible wall that is a complex amalgam of cellulose microfibrils bonded noncovalently to a matrix of hemicelluloses, pectins, and structural proteins. Cellulose is synthesized by complexes in the plasma membrane and is extruded as a self-assembling microfibril, whereas the matrix... | 10.1146/annurev.cellbio.13.1.171 | 9,442,872 | D002473:Cell Wall; D002482:Cellulose; D010368:Pectins; D010940:Plant Proteins; D010944:Plants; D011134:Polysaccharides | Annual review of cell and developmental biology | 1,997 | D010940:Plant Proteins; D011134:Polysaccharides; C095825:expansin protein, plant; D010368:Pectins; D002482:Cellulose |
Autism, an extreme challenge to integrative medicine. Part: 1: The knowledge base. | Autism, archetype of the autistic spectrum disorders (ASD), is a neurodevelopmental disorder characterized by socially aloof behavior and impairment of language and social interaction. Its prevalence has surged in recent years. Advanced functional brain imaging has confirmed pervasive neurologic involvement. Parent inv... | 12,197,782 | D001321:Autistic Disorder; D001921:Brain; D002490:Central Nervous System; D002560:Cerebrovascular Circulation; D002648:Child; D002657:Child Development; D019033:Delivery of Health Care, Integrated; D002658:Developmental Disabilities; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007107:Immune System; ... | Alternative medicine review : a journal of clinical therapeutic | 2,002 | D015262:Xenobiotics | |
Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the fetal alcohol syndrome. | In utero exposure to ethanol is deleterious to fetal brain development. Children born with the fetal alcohol syndrome (FAS) display a number of abnormalities, the most significant of which are central nervous system (CNS) dysfunctions, such as microencephaly and mental retardation. An interaction of ethanol with glial ... | 10.1016/S0161-813X(02)00009-8 | 12,520,758 | D000818:Animals; D001253:Astrocytes; D002455:Cell Division; D000431:Ethanol; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders; D006131:Growth Inhibitors; D006801:Humans; D018727:Muscarinic Antagonists; D011247:Pregnancy; D011976:Receptors, Muscarinic; D015398:Signal Transduction | Neurotoxicology | 2,002 | D006131:Growth Inhibitors; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D000431:Ethanol |
Keys to genera of the spider wasps (Hymenoptera: Pompilidae) of Russia and neighbouring countries, with check-list of genera. | Keys to 55 genera of spider wasps of Russia and neighbouring countries in females and males are given. Of them 34 genera are distributed in Russia. An annotated list of genera with type species and distribution data within Russia and biogeographical regions is given. The genus Xenaporus Ashmead, 1902 and X. eremocanus ... | 10.11646/zootaxa.4034.1.4 | 26,624,432 | D063147:Animal Distribution; D000825:Animal Structures; D000818:Animals; D049628:Body Size; D017753:Ecosystem; D005260:Female; D008297:Male; D009929:Organ Size; D012426:Russia; D014863:Wasps | Zootaxa | 2,015 | |
Modulatory effects of heparin and short-length oligosaccharides of heparin on the metastasis and growth of LMD MDA-MB 231 breast cancer cells in vivo. | Expression of the chemokine receptor CXCR4 allows breast cancer cells to migrate towards specific metastatic target sites which constitutively express CXCL12. In this study, we determined whether this interaction could be disrupted using short-chain length heparin oligosaccharides. Radioligand competition binding assay... | 10.1038/sj.bjc.6603928 | 17,726,466 | D000818:Animals; D000970:Antineoplastic Agents; D001943:Breast Neoplasms; D002465:Cell Movement; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006495:Heparin, Low-Molecular-Weight; D006497:Heparitin Sulfate; D006801:Humans; D007150:Immunohistochemist... | British journal of cancer | 2,007 | D000970:Antineoplastic Agents; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D006495:Heparin, Low-Molecular-Weight; D007457:Iodine Radioisotopes; D009844:Oligosaccharides; D011108:Polymers; D019718:Receptors, CXCR4; D000078222:Tinzaparin; D006497:Hepari... |
Evidence for a distinct light-induced calcium-dependent potassium current in Hermissenda crassicornis. | A model of phototransduction is developed as a first step toward a model for investigating the critical interaction of light and turbulence stimuli within the type B photoreceptor of Hermissenda crassicronis. The model includes equations describing phototransduction, release of calcium from intracellular stores, and ot... | 10.1023/a:1008919924579 | 11,030,519 | D000818:Animals; D002118:Calcium; D020013:Calcium Signaling; D002462:Cell Membrane; D008564:Membrane Potentials; D023421:Models, Animal; D008959:Models, Neurological; D008974:Mollusca; D010775:Photic Stimulation; D017956:Photoreceptor Cells, Invertebrate; D015221:Potassium Channels; D015222:Sodium Channels; D014785:Vis... | Journal of computational neuroscience | 2,000 | D015221:Potassium Channels; D015222:Sodium Channels; D002118:Calcium |
A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration. | We have probed the nucleoprotein organization of Moloney murine leukemia virus (MLV) pre-integration complexes using a novel footprinting technique that utilizes a simplified in vitro phage Mu transposition system. We find that several hundred base pairs at each end of the viral DNA are organized in a large nucleoprote... | 10.1093/emboj/16.24.7511 | 9,405,379 | D000818:Animals; D010583:Bacteriophage mu; D001482:Base Composition; D001483:Base Sequence; D004247:DNA; D018983:DNA Footprinting; D004251:DNA Transposable Elements; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D051379:Mice; D008969:Molecular Sequence Data; D008979:Moloney murine leukemia virus; D016254:Mutagenesi... | The EMBO journal | 1,997 | D004251:DNA Transposable Elements; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D009698:Nucleoproteins; D009838:Oligodeoxyribonucleotides; D004247:DNA |
Do your staff know the cost of pharmaceuticals and lab tests? | ED physicians often are misinformed about the cost of diagnostic tests and drugs. Physicians tend to overuse tests and treatments that do not improve patient care, according to ED experts. Comparing test utilization with peers is a strong motivator for physicians. Listing costs of antibiotics on protocols can cut costs... | 10,558,101 | D001364:Awareness; D019411:Clinical Laboratory Techniques; D003363:Cost Control; D016527:Drug Costs; D004636:Emergency Service, Hospital; D017721:Hospital Costs; D008505:Medical Staff, Hospital; D014481:United States; D019564:Unnecessary Procedures | ED management : the monthly update on emergency department management | 1,999 | ||
Application of cell traction force microscopy for cell biology research. | When a cell migrates, it generates traction forces on the underlying substrate. The cell traction force (CTF) is not only essential for cell migration, but it is also used by cells to control their shape and maintain cellular homeostasis. As such, quantification of CTFs aids in better understanding of many fundamental ... | 10.1007/978-1-60761-376-3_17 | 19,768,438 | D000818:Animals; D001696:Biomechanical Phenomena; D035843:Biomedical Research; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D002465:Cell Movement; D024042:Collagen Type I; D003315:Cornea; D003470:Culture Media; D005347:Fibroblasts; D006801:Humans; D051379:Mice; D008853:Microscop... | Methods in molecular biology (Clifton, N.J.) | 2,009 | D024042:Collagen Type I; D003470:Culture Media |
Use of an anionic collagen matrix made from bovine intestinal serosa for in vivo repair of cranial defects. | Polymeric biomaterials composed of extracellular matrix components possess osteoconductive capacity that is essential for bone healing. The presence of collagen and the ability to undergo physicochemical modifications render these materials a suitable alternative in bone regenerative therapies. The objective of this st... | 10.1371/journal.pone.0197806 | 30,001,321 | D000818:Animals; D015415:Biomarkers; D001861:Bone Regeneration; D002113:Calcification, Physiologic; D002417:Cattle; D003094:Collagen; D005109:Extracellular Matrix; D015870:Gene Expression; D007422:Intestines; D015675:Osteocalcin; D010012:Osteogenesis; D051381:Rats; D017208:Rats, Wistar; D012704:Serous Membrane; D012886... | PloS one | 2,018 | D015415:Biomarkers; D015675:Osteocalcin; D003094:Collagen |
A Fluorescent Sensor for Cu2+ Ion with High Selectivity and Sensitivity Based on ICT and PET. | A novel fluorescent sensor (L) based on 1,8-naphthalic anhydride has been developed which can selectively detect Cu2+ in CH3CN medium over other metal ions at 408 nm in the fluorescence spectra. When Cu2+ was added into L, L showed fluorescent turn-off by coordinating with Cu2+. A fresh absorption band was found at the... | 10.1007/s10895-019-02406-z | 31,420,781 | D003300:Copper; D004579:Electron Transport; D005456:Fluorescent Dyes; D015394:Molecular Structure; D009281:Naphthalenes; D055668:Photochemical Processes; D013050:Spectrometry, Fluorescence | Journal of fluorescence | 2,019 | D005456:Fluorescent Dyes; D009281:Naphthalenes; C012514:1,8-naphthalenedicarboxylic acid anhydride; D003300:Copper |
In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum. | OBJECTIVES
The in vitro activities of FR160, a synthetic catecholate siderophore, and two iron-binding agents, desferrioxamine and doxycycline, were evaluated against Plasmodium falciparum isolates. Correlations between these compounds and standard antimalarial drugs (chloroquine, quinine, amodiaquine, pyronaridine, ar... | 10.1093/jac/dkl117 | 16,595,639 | D000818:Animals; D000962:Antimalarials; D003676:Deferoxamine; D004318:Doxycycline; D004351:Drug Resistance; D006801:Humans; D020128:Inhibitory Concentration 50; D007502:Iron Chelating Agents; D016778:Malaria, Falciparum; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum; D012675:Senegal; D013095:Spermi... | The Journal of antimicrobial chemotherapy | 2,006 | D000962:Antimalarials; C108048:FR 160; D007502:Iron Chelating Agents; D003676:Deferoxamine; D004318:Doxycycline; D013095:Spermidine |
Phytoconstituents as photoprotective novel cosmetic formulations. | Phytoconstituents are gaining popularity as ingredients in cosmetic formulations as they can protect the skin against exogenous and endogenous harmful agents and can help remedy many skin conditions. Exposure of skin to sunlight and other atmospheric conditions causes the production of reactive oxygen species, which ca... | 10.4103/0973-7847.65319 | 22,228,936 | Pharmacognosy reviews | 2,010 | ||
Correction: Advances in non-enzymatic glucose sensors based on metal oxides. | Correction for 'Advances in non-enzymatic glucose sensors based on metal oxides' by Hua Zhu et al., J. Mater. Chem. B, 2016, 4, 7333-7349. | 10.1039/c7tb90011b | 32,263,889 | Journal of materials chemistry. B | 2,017 | ||
The mechanism by which rat liver glucokinase is inhibited by the regulatory protein. | The fructose-6-phosphate-sensitive and fructose-1-phosphate-sensitive protein that inhibits rat liver glucokinase [Van Schaftingen, E. (1989) Eur. J. Biochem. 179, 179-184] was purified close to homogeneity by a procedure involving poly(ethyleneglycol) precipitation, chromatography on anion-exchangers and hydroxylapati... | 10.1111/j.1432-1033.1990.tb19147.x | 2,384,095 | D000818:Animals; D002499:Centrifugation, Density Gradient; D002845:Chromatography; D002850:Chromatography, Gel; D005636:Fructosephosphates; D005941:Glucokinase; D005947:Glucose; D008099:Liver; D011506:Proteins; D051381:Rats; D014357:Trypsin | European journal of biochemistry | 1,990 | D005636:Fructosephosphates; D011506:Proteins; C032284:fructose-1-phosphate; C027618:fructose-6-phosphate; D005941:Glucokinase; D014357:Trypsin; D005947:Glucose |
CXCL12 expression is a bona fide predictor of recurrence in lung neuroendocrine tumours; a multicentric study with emphasis on atypical carcinoids - a short report. | PURPOSE
Neuroendocrine tumors of the lung (LNETs) encompass a heterogeneous group of lesions, including tumors with no or low metastatic potential, such as typical (TCs) and atypical (ACs) carcinoids, and highly aggressive neuroendocrine carcinomas. To date, only a few biomarkers with prognostic impact have been identi... | 10.1007/s13402-018-0401-9 | 30,182,340 | D000368:Aged; D002276:Carcinoid Tumor; D054377:Chemokine CXCL12; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018358:Neuroendocrine Tumors | Cellular oncology (Dordrecht) | 2,018 | C515255:CXCL12 protein, human; D054377:Chemokine CXCL12 |
European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology. | BACKGROUND
Evidence regarding functional hypogonadism, previously referred to as 'late-onset' hypogonadism, has increased substantially during the last 10 year.
OBJECTIVE
To update the European Academy of Andrology (EAA) guidelines on functional hypogonadism.
METHODS
Expert group of academicians appointed by the EA... | 10.1111/andr.12770 | 32,026,626 | D000328:Adult; D005060:Europe; D006801:Humans; D007006:Hypogonadism; D008019:Life Style; D008297:Male; D008991:Monitoring, Physiologic; D013739:Testosterone | Andrology | 2,020 | D013739:Testosterone |
Analysis of construction injury burden by type of work. | BACKGROUND
To lay groundwork for identifying patterns of injury etiology, we sought to describe injury experience associated with types of work performed at construction sites by examining workers' compensation (WC) claims for the 32,081 construction workers who built Denver International Airport (DIA).
METHODS
Injur... | 10.1002/(sici)1097-0274(200004)37:4<390::aid-ajim9>3.0.co;2-0 | 10,706,751 | D000041:Absenteeism; D001359:Aviation; D016009:Chi-Square Distribution; D003120:Colorado; D006801:Humans; D007345:Insurance Claim Review; D008669:Metallurgy; D018986:Motor Vehicles; D009784:Occupational Diseases; D009790:Occupations; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors; D0... | American journal of industrial medicine | 2,000 | D013232:Steel |
Impact of complete and incomplete revascularization on short- and long-term quality of life in patients with multivessel coronary artery disease. | OBJECTIVE
In this study, we compared the impact of two main strategies of intervention against multivessel coronary disease (MVD), complete revascularization (CR) and incomplete revascularization (IR), on patients' quality of life.
PATIENTS AND METHODS
210 patients with multivessel disease were selected for this stud... | 27,874,937 | D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease; D006801:Humans; D009204:Myocardial Revascularization; D011788:Quality of Life; D016896:Treatment Outcome | European review for medical and pharmacological sciences | 2,016 | ||
Neutron shielding material based on colemanite and epoxy resin. | In recent years, there has been a need for compact shielding design such as self-shielding of a PET cyclotron or upgradation of radiation machinery in existing facilities. In these cases, high performance shielding materials are needed. Concrete or polyethylene have been used for a neutron shield. However, for compact ... | 10.1093/rpd/nci154 | 16,381,724 | D001881:Borates; D004853:Epoxy Resins; D008420:Manufactured Materials; D008422:Materials Testing; D009502:Neutrons; D011829:Radiation Dosage; D011835:Radiation Protection; D011874:Radiometry; D012542:Scattering, Radiation | Radiation protection dosimetry | 2,005 | D001881:Borates; D004853:Epoxy Resins |
Recessive Dystrophic Epidermolysis Bullosa: Rare Bilateral External Auditory Canal Stenosis and Surgical Treatment. | Epidermolysis bullosa (EB) is a family of rare genetic disorders affecting the skin and mucous membranes, causing blisters and lesions. Its treatment is based on the prevention of traumatic events that could favor the onset of blisters as well as careful wound care. New therapies, including gene therapy, are under inve... | 10.1177/11795476221131196 | 36,544,566 | Clinical medicine insights. Case reports | 2,022 | ||
The levonorgestrel-releasing intrauterine system: an updated review of the contraceptive and noncontraceptive uses. | The levonorgestrel containing intrauterine system is an effective and safe form of long-term yet reversible birth control. Intrauterine contraception use in the United States fell dramatically after early studies reported an association between intrauterine contraception use and later tubal infertility. Subsequent eval... | 10.1097/GRF.0b013e318159c0d9 | 17,982,331 | D003362:Cost-Benefit Analysis; D004715:Endometriosis; D005260:Female; D052776:Female Urogenital Diseases; D006801:Humans; D007247:Infertility, Female; D007436:Intrauterine Devices, Medicated; D007889:Leiomyoma; D008595:Menorrhagia; D018570:Risk Assessment; D012307:Risk Factors | Clinical obstetrics and gynecology | 2,007 | |
Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport. | Syntaxin 4 is a component of the SNARE complex that regulates membrane docking and fusion. Using a yeast two-hybrid screen, we identify a novel interaction between syntaxin 4 and cytoplasmic murine CENPF, a protein previously demonstrated to associate with the microtubule network and SNAP-25. The binding domain for syn... | 10.1242/jcs.032847 | 18,827,011 | D000818:Animals; D001692:Biological Transport; D019556:COS Cells; D002462:Cell Membrane; D002522:Chlorocebus aethiops; D002868:Chromosomal Proteins, Non-Histone; D003593:Cytoplasm; D051275:Glucose Transporter Type 4; D051379:Mice; D008840:Microfilament Proteins; D008870:Microtubules; D041681:NIH 3T3 Cells; D050765:Qa-S... | Journal of cell science | 2,008 | D002868:Chromosomal Proteins, Non-Histone; D051275:Glucose Transporter Type 4; D008840:Microfilament Proteins; D050765:Qa-SNARE Proteins; C495693:Slc2a4 protein, mouse; D050825:Synaptosomal-Associated Protein 25; D050988:Vesicle-Associated Membrane Protein 2; C094772:centromere protein F; C494808:vesicle-associated mem... |
Novel homozygous variant in the TPO gene associated with congenital hypothyroidism and mild-intellectual disability. | Congenital hypothyroidism (CH) is one of the most common hereditary disorders affecting neonates worldwide. CH is a multifactorial complex disorder and can be caused by either environmental factors or genetic factors. We studied one Pakistani family with segregating mutations in CH inherited in an autosomal recessive m... | 10.1038/s41439-020-00129-3 | 33,298,898 | Human genome variation | 2,020 | ||
Immortalized cerebellar cells can be induced to display mature neuronal characteristics. | We have established and characterized a cell line (designated Cb-E1A) that can be induced to display a variety of neuronal characteristics under simple culture conditions. This cell line was generated by retroviral-mediated gene transfer of the adenovirus 12S E1A-immortalizing gene in cerebellar cells isolated from one... | 10.1016/0306-4522(96)00129-7 | 8,865,201 | D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D002531:Cerebellum; D007150:Immunohistochemistry; D016900:Neurofilament Proteins; D009474:Neurons; D051381:Rats | Neuroscience | 1,996 | D016900:Neurofilament Proteins |
[Chromosome aberration in a full-term neonate with low birth weight using microarray comparative genomic hybridization]. | OBJECTIVE
To analyze the chromosome aberration in a full-term male neonate with low birth weight, and to explore the possible causes for growth retardation in intrauterine development for the neonate.
METHODS
Genomic DNA was extracted from peripheral leukocytes of the neonate. Detection of genomic DNA copy number gai... | 18,841,570 | D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D055028:Comparative Genomic Hybridization; D005260:Female; D018628:Gene Dosage; D015894:Genome, Human; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007621:Karyotyping; D008297... | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics | 2,008 | ||
Bioactivation of catechol in rat and human bone marrow cells. | o-Benzoquinone-glutathione (GSH) conjugate formation and covalent binding of [14C]catechol to protein were utilized as probes of bioactivation of catechol in both rat and human white bone marrow cell systems. Conjugate formation and binding occurred in the absence of exogenous hydrogen peroxide, but were markedly stimu... | 10.1016/0041-008x(88)90271-2 | 3,388,426 | D000818:Animals; D001711:Biotransformation; D001853:Bone Marrow; D002396:Catechols; D005978:Glutathione; D006801:Humans; D006861:Hydrogen Peroxide; D008297:Male; D019800:Phenol; D010636:Phenols; D051381:Rats; D011919:Rats, Inbred Strains | Toxicology and applied pharmacology | 1,988 | D002396:Catechols; D010636:Phenols; D019800:Phenol; D006861:Hydrogen Peroxide; D005978:Glutathione; C034221:catechol |
No changes in infliximab levels in blood stored for preoperative autologous blood donation. | Rheumatoid arthritis (RA) patients requiring total joint arthroplasties under administration of infliximab, which may remain in donated blood if preoperative autologous blood donation (PABD) is undertaken for the surgery, may risk infection. We clarified infliximab hemokinetics in blood stored for such patients. A 20-m... | 10.1007/s10165-007-0008-x | 18,094,932 | D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D001178:Arthroplasty; D001771:Blood Banks; D001793:Blood Preservation; D001804:Blood Transfusion, Autologous; D015331:Cohort Studies; D005260:Female; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged | Modern rheumatology | 2,008 | D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D000069285:Infliximab |
The Herbert bone screw and its applications in foot surgery. | The author presents multiple indications of the Herbert bone screw in foot surgery. Both cannulated and noncannulated systems are discussed along with operative steps for several of the more common procedures performed by the author with this type screw. The Herbert bone screw systems provide another alternative for in... | 7,951,186 | D000842:Ankle; D001863:Bone Screws; D005528:Foot; D006801:Humans; D008722:Methods; D010027:Osteotomy; D011474:Prosthesis Design | The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons | 1,994 | ||
Enhance patient safety by identifying and minimizing risk exposures affecting nurse practitioner practice. | A study analyzing closed professional liability claims against nurse practitioners over a 5-year period was completed by CNA and Nurses Service Organization (NSO). Of 200 closed claims, the average total incurred payment per claim was $285 645. The study identifies current liability patterns and trends and provides ris... | 10.1002/jhrm.21124 | 24,078,206 | D035881:Compensation and Redress; D004282:Documentation; D006801:Humans; D016365:Liability, Legal; D008008:Licensure, Nursing; D019300:Medical Errors; D009722:Nurse Practitioners; D061214:Patient Safety; D014481:United States | Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management | 2,013 | |
Clinical findings in dogs with incidental adrenal gland lesions determined by ultrasonography: 151 cases (2007-2010). | OBJECTIVE
To determine the prevalence of and clinical features associated with incidental adrenal gland lesions (IAGLs) discovered during abdominal ultrasonography in dogs.
DESIGN
Retrospective case series.
ANIMALS
151 dogs with an IAGL and 400 control dogs.
PROCEDURES
Reports of ultrasonographic examinations of ... | 10.2460/javma.244.10.1181 | 24,786,166 | D000310:Adrenal Gland Neoplasms; D000818:Animals; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D008297:Male; D012189:Retrospective Studies; D014463:Ultrasonography | Journal of the American Veterinary Medical Association | 2,014 | |
Feeding a High Concentrate Diet Down-Regulates Expression of ACACA, LPL and SCD and Modifies Milk Composition in Lactating Goats. | High concentrate diets are fed to early and mid-lactation stages dairy ruminants to meet the energy demands for high milk production in modern milk industry. The present study evaluated the effects of a high concentrate diet on milk fat and milk composition, especially, cis-9, trans-11 CLA content in milk and gene expr... | 10.1371/journal.pone.0130525 | 26,086,219 | D000103:Acetyl-CoA Carboxylase; D000818:Animals; D019175:DNA Methylation; D004032:Diet; D015536:Down-Regulation; D064429:Fatty Acid Synthases; D005227:Fatty Acids; D005260:Female; D006041:Goats; D007536:Isomerism; D007774:Lactation; D044243:Linoleic Acids, Conjugated; D008070:Lipopolysaccharides; D008071:Lipoprotein Li... | PloS one | 2,015 | D005227:Fatty Acids; D044243:Linoleic Acids, Conjugated; D008070:Lipopolysaccharides; D009829:Oleic Acids; D051780:Sterol Regulatory Element Binding Protein 1; D013230:Stearoyl-CoA Desaturase; D064429:Fatty Acid Synthases; D008071:Lipoprotein Lipase; D000103:Acetyl-CoA Carboxylase; C050413:11-octadecenoic acid |
Clinical monitoring of neuromuscular function. | With the advent of shorter-acting non-depolarizing neuromuscular blocking drugs, the use of nerve stimulation as a means of monitoring the neuromuscular junction has become more widespread. This article describes the patterns of nerve stimulation and modes of monitoring muscular response in current clinical use. These ... | 1,458,272 | D000054:Acceleration; D000758:Anesthesia; D004558:Electric Stimulation; D006801:Humans; D008991:Monitoring, Physiologic; D009132:Muscles; D009213:Myography; D009466:Neuromuscular Blocking Agents; D009469:Neuromuscular Junction | British journal of hospital medicine | 1,992 | D009466:Neuromuscular Blocking Agents | |
Cytoplasmic vacuolation, intracytoplasmic lumina, and DPAS staining in ductal carcinoma of the breast. | A retrospective study was carried out on 30 cases of histologically proven invasive ductal carcinoma of the breast with a prior fine-needle aspiration (FNA) cytology. On evaluating the May-Grünwald-Giemsa (MGG) FNA smears, cytoplasmic vacuolation was observed in 70% cases. Positivity with periodic acid Schiff-positive,... | 10.1002/dc.10272 | 12,768,632 | D000681:Amylases; D001707:Biopsy, Needle; D001943:Breast Neoplasms; D018270:Carcinoma, Ductal, Breast; D005260:Female; D006801:Humans; D010503:Periodic Acid-Schiff Reaction; D012189:Retrospective Studies; D014617:Vacuoles | Diagnostic cytopathology | 2,003 | D000681:Amylases |
miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis. | Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explai... | 10.1007/s13277-016-5156-1 | 27,468,722 | D000818:Animals; D063646:Carcinogenesis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs; D009369:Neoplasms; D014411:Neoplastic Stem Cells | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 2,016 | D035683:MicroRNAs |
Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. | Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) and cyclooxygenase inhibitor that is frequently used as a research tool to study the process of adipocyte differentiation. Treatment of various preadipocyte cell lines with micromolar concentrations of indomethacin in the presence of insulin promotes their ... | 10.1074/jbc.272.6.3406 | 9,013,583 | D000273:Adipose Tissue; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002454:Cell Differentiation; D006801:Humans; D007052:Ibuprofen; D007213:Indomethacin; D008099:Liver; D051379:Mice; D008809:Mice, Inbred C3H; D008830:Microbodies; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclea... | The Journal of biological chemistry | 1,997 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D007052:Ibuprofen; D007213:Indomethacin |
Pharmacotherapy for Perinatal Depression. | Perinatal depression is associated with serious risks for the mother, baby, and family. When considering treating perinatal depression with a drug indicated for the treatment of depression, the major concerns are whether the drug increases the risks of teratogenicity, pregnancy complications, poor neonatal adaptation, ... | 10.1097/GRF.0000000000000365 | 29,561,284 | D000014:Abnormalities, Drug-Induced; D000022:Abortion, Spontaneous; D000929:Antidepressive Agents, Tricyclic; D000067877:Autism Spectrum Disorder; D001569:Benzodiazepines; D016642:Bupropion; D002657:Child Development; D003863:Depression; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, ... | Clinical obstetrics and gynecology | 2,018 | D000929:Antidepressive Agents, Tricyclic; D008996:Monoamine Oxidase Inhibitors; D017367:Serotonin Uptake Inhibitors; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors; D016642:Bupropion; D001569:Benzodiazepines |
Doppler myocardial imaging in adult male rats: reference values and reproducibility of velocity and deformation parameters. | AIM
Limited data are available about the use of Doppler myocardial imaging (DMI) in small animals. We intend to provide reference values for velocity, strain and strain rate in a large group of healthy rats and studied the reproducibility and repeatability of these parameters.
METHODS AND RESULTS
A total of 33 male W... | 10.1016/j.euje.2006.03.009 | 16,672,194 | D000818:Animals; D018618:Echocardiography, Doppler, Color; D005240:Feasibility Studies; D006339:Heart Rate; D008297:Male; D009200:Myocardial Contraction; D015588:Observer Variation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D015203:Reproducibility of Results | European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology | 2,006 | |
Emotional, physical, and sexual abuse in fibromyalgia syndrome: a systematic review with meta-analysis. | OBJECTIVE
To systematically assess the potential association of fibromyalgia syndrome (FMS) with emotional, physical, and sexual abuse.
METHODS
The databases EMBase, Google Scholar, Medline, and PsycINFO (through April 2010) and the reference sections of original studies were searched for eligible studies. Eligible s... | 10.1002/acr.20328 | 20,722,042 | D054523:Adult Survivors of Child Abuse; D016022:Case-Control Studies; D004644:Emotions; D005356:Fibromyalgia; D006801:Humans; D012307:Risk Factors; D012742:Sex Offenses; D013577:Syndrome | Arthritis care & research | 2,011 | |
Acetate-free bicarbonate dialysate: Which acid in the dialysis buffer? | The mix of bicarbonate and divalent cations requires a small amount of acid to avoid insoluble precipitation in the dialysate buffer. Small doses of acetic acid (3–7 mmol/L) are commonly used. Acetic acid may be replaced by hydrochloric acid or citric acid to achieve acetate-free haemodialysis. Hydrochloric acid theore... | 10.1016/j.nephro.2019.02.003 | 30,981,402 | Nephrologie & therapeutique | 2,019 | ||
Short photoperiod reduces the temperature sensitivity of leaf-out in saplings of Fagus sylvatica but not in horse chestnut. | Leaf phenology is one of the most reliable bioindicators of ongoing global warming in temperate and boreal zones because it is highly sensitive to temperature variation. A large number of studies have reported advanced spring leaf-out due to global warming, yet the temperature sensitivity of leaf-out has significantly ... | 10.1111/gcb.14599 | 30,779,408 | D031319:Aesculus; D005060:Europe; D029964:Fagus; D065928:Forests; D057232:Global Warming; D017440:Photoperiod; D018515:Plant Leaves; D012621:Seasons; D013045:Species Specificity; D013696:Temperature | Global change biology | 2,019 | |
The configurational effects of task-technology fit, technology-induced engagement and motivation on learning performance during Covid-19 pandemic: An fsQCA approach. | At the onset of 2020, Covid-19 pandemic began and disrupted teaching and learning activities with substantial implications for resources and operations. Against this backdrop, the configural causal effects of task-technology fit, technology-induced engagement and motivation, gender, and residential location on learning... | 10.1007/s10639-021-10580-6 | 34,031,629 | Education and information technologies | 2,021 | ||
Nifedipine or verapamil counteracts hypertension in gravid ewes. | Hypertension frequently complicates endotracheal intubation in the severely preeclamptic parturient. The calcium entry-blocking drugs nifedipine (N) and verapamil (V) are effective antihypertensive agents in nonpregnant patients. The authors studied the maternal and fetal hemodynamic effects of these drugs in chronical... | 3,752,569 | D000818:Animals; D001784:Blood Gas Analysis; D005260:Female; D006973:Hypertension; D009543:Nifedipine; D009638:Norepinephrine; D011225:Pre-Eclampsia; D011247:Pregnancy; D012039:Regional Blood Flow; D012756:Sheep; D014599:Uterus; D014700:Verapamil | Anesthesiology | 1,986 | D014700:Verapamil; D009543:Nifedipine; D009638:Norepinephrine | |
Strong Interactions between Austenite and the Matrix of Medium-Mn Steel during Intercritical Annealing. | The effects of heat treatment on the microstructure evolution was studied in regards to austenite nucleation and grain growth. It was found that the austenite nucleation and matrix recrystallization kinetics of samples annealed at 675 °C for different times were revealed, implying a strong interaction between the ferri... | 10.3390/ma13153366 | 32,751,247 | Materials (Basel, Switzerland) | 2,020 | ||
Jacareubin inhibits TLR4-induced lung inflammatory response caused by the RBD domain of SARS-CoV-2 Spike protein. | BACKGROUND
COVID-19, the disease caused by SARS-CoV-2 virus infection, has been a major public health problem worldwide in the last 2 years. SARS-CoV-2-dependent activation of innate immune receptors contributes to the strong local and systemic inflammatory reaction associated with rapid disease evolution. The receptor... | 10.1007/s43440-022-00398-5 | 35,930,194 | D000818:Animals; D051379:Mice; D003907:Dexamethasone; D015850:Interleukin-6; D008168:Lung; D000086402:SARS-CoV-2; D064370:Spike Glycoprotein, Coronavirus; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; D044004:Xanthones; D000093485:COVID-19 Drug Treatment; D007249:Inflammation | Pharmacological reports : PR | 2,022 | D003907:Dexamethasone; D015850:Interleukin-6; D064370:Spike Glycoprotein, Coronavirus; C000657845:spike protein, SARS-CoV-2; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; C000624232:jacareubin; D044004:Xanthones |
Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation. | The Notch signaling regulator Numblike (Numbl) is expressed in the brain, but little is known regarding its role in the pathophysiology of glial cells. In this paper, we report that Numbl expression was down-regulated in high-grade human glioma tissue samples and glioblastoma cell lines. To investigate the role of Numb... | 10.1091/mbc.E11-09-0805 | 22,593,207 | D001921:Brain; D001932:Brain Neoplasms; D045744:Cell Line, Tumor; D002465:Cell Movement; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; D009361:Neoplasm Invasiveness; D015398:Signal Transduction; D048015:TN... | Molecular biology of the cell | 2,012 | D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; C530266:NUMBL protein, human; D048015:TNF Receptor-Associated Factor 5 |
Hispanic ethnicity and complication profile following laparoscopic and open cholecystectomy. | BACKGROUND
Hispanic ethnicity is associated with increased incidence of gallbladder disease. Additionally, ethnicity has been shown to be an outcome determinant in several conditions and procedures but has never been studied as a potential determinant of morbidity or mortality after laparoscopic or open cholecystectomy... | 10.1016/j.jss.2017.05.121 | 29,078,901 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D016208:Databases, Factual; D005260:Female; D054624:Health Status Disparities; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate A... | The Journal of surgical research | 2,017 | |
Synthesis, Characterisation, and Functionalisation of Charged Two-Dimensional MoS2. | The applications of exfoliated MoS2 are limited by its inert surface and poor interface. We have activated the surface of exfoliated 2H-MoS2 by reacting it with NaBH4 , forming an n-doped material as demonstrated by a negative zeta-potential value ζ=-25 mV and a 20 nm (0.05 eV) red-shift in its photoluminescence spectr... | 10.1002/chem.202302039 | 37,534,612 | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,023 | ||
Improving prescription drug warnings to promote patient comprehension. | BACKGROUND
Prior studies have documented a high prevalence of patients who misunderstand prescription drug warning labels, placing them at risk for medication error. We evaluated whether the use of "enhanced print" drug warnings could improve patient comprehension beyond a current standard.
METHODS
An evaluation of e... | 10.1001/archinternmed.2009.454 | 20,065,199 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002641:Chicago; D032882:Comprehension; D004348:Drug Labeling; D004522:Educational Status; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D007407:Interviews as Topic; D016014:Linear Models; D008145:Louisiana; D008297:Male; D008508... | Archives of internal medicine | 2,010 | D055553:Prescription Drugs |
A Novel In-Home Sleep Monitoring System Based on Fully Integrated Multichannel Front-End Chip and Its Multilevel Analyses. | OBJECTIVE
A novel in-home sleep monitoring system with an 8-channel biopotential acquisition front-end chip is presented and validated via multilevel data analyses and comparision with advanced polysomnography.
METHODS AND PROCEDURES
The chip includes a cascaded low-noise programmable gain amplifier (PGA) and 24-bit ... | 10.1109/JTEHM.2023.3248621 | 36,950,263 | D006801:Humans; D017286:Polysomnography; D055361:Multilevel Analysis; D004867:Equipment Design; D017097:Electric Impedance | IEEE journal of translational engineering in health and medicine | 2,023 | |
[Severe hypophosphatemia and grave head trauma]. | The authors report the case of an 18-year-old man with polytrauma, who died at the third day of its accident from brain death and who presented during his stay in the intensive care unit, a deep hypophosphatemia. Two physiopathologic mechanisms were presumed: increase of renal losses and intracellular transfer of phosp... | 10.1016/s0750-7658(02)00647-0 | 12,134,598 | D000293:Adolescent; D006259:Craniocerebral Trauma; D017809:Fatal Outcome; D006801:Humans; D017674:Hypophosphatemia; D007668:Kidney; D008297:Male; D009104:Multiple Trauma; D009638:Norepinephrine; D010758:Phosphorus | Annales francaises d'anesthesie et de reanimation | 2,002 | D010758:Phosphorus; D009638:Norepinephrine |
Achieving succession planning and implementation: one healthcare network's story. | Frequent transitions in leadership can cause inefficiency, inconsistency, and lack of alignment with priorities and strategy. Retaining management talent and collaboratively planning their succession can help ensure organizational survival. Succession planning, in healthcare and other industries, addresses some of thes... | 10.1016/j.hcmf.2013.06.003 | 24,409,581 | D002322:Career Mobility; D006270:Health Facility Administrators; D007857:Leadership; D009096:Multi-Institutional Systems; D019982:Organizational Case Studies; D010414:Pennsylvania; D010934:Planning Techniques | Healthcare management forum | 2,013 | |
Speciation on a local geographic scale: the evolution of a rare rock outcrop specialist in Mimulus. | Speciation can occur on both large and small geographical scales. In plants, local speciation, where small populations split off from a large-ranged progenitor species, is thought to be the dominant mode, yet there are still few examples to verify speciation has occurred in this manner. A recently described morphologic... | 24,958,929 | D000220:Adaptation, Biological; D000704:Analysis of Variance; D005075:Biological Evolution; D002140:California; D017753:Ecosystem; D056426:Genetic Loci; D049810:Genetic Speciation; D014644:Genetic Variation; D059646:Genome Size; D005843:Geography; D006824:Hybridization, Genetic; D018895:Microsatellite Repeats; D032241:... | Philosophical transactions of the Royal Society of London. Series B, Biological sciences | 2,014 | ||
Sensitivity shift theory: A developmental model of positive affect and motivational deficits in social anxiety disorder. | Social anxiety disorder (SAD) is a common and impairing condition that emerges in early adolescence, confers significant interpersonal disability and often persists into adulthood. Prevailing interventions for socially anxious youth are largely based on cognitive-behavioral models originally developed in adult samples,... | 10.1016/j.cpr.2019.101756 | 31,351,312 | D000293:Adolescent; D000328:Adult; D000339:Affect; D059445:Anhedonia; D006803:Human Development; D006801:Humans; D008962:Models, Theoretical; D009042:Motivation; D000072861:Phobia, Social; D012919:Social Behavior; D066107:Social Skills; D055815:Young Adult | Clinical psychology review | 2,019 | |
Extracellular Vesicles Act as Nano-Transporters of Tyrosine Kinase Inhibitors to Revert Iodine Avidity in Thyroid Cancer. | A new approach for using extracellular vesicles (EVs) to deliver tyrosine kinase inhibitors (TKIs) to enhance iodine avidity in radioactive iodine-refractory thyroid cancer is needed. We isolated and characterized primary human adipose-derived stem cells (ADSCs) and isolated their EVs. The EVs were characterized by tra... | 10.3390/pharmaceutics13020248 | 33,578,882 | Pharmaceutics | 2,021 | ||
Genotyped indigenous Kiwcha adults at high altitude are lighter and shorter than their low altitude counterparts. | BACKGROUND
Anthropometric measures have been classically used to understand the impact of environmental factors on the living conditions of individuals and populations. Most reference studies on development and growth in which anthropometric measures were used were carried out in populations that are located at sea lev... | 10.1186/s40101-022-00280-6 | 35,272,696 | D000328:Adult; D000531:Altitude; D000886:Anthropometry; D001823:Body Composition; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male | Journal of physiological anthropology | 2,022 | |
[Severe aplastic anemia after BTN162b2 mRNA COVID-19 vaccination in a patient undergoing hemodialysis]. | Although vaccination against coronavirus infection 2019 (COVID-19) has been found to be effective, reports of adverse reactions continue to appear. We report the development of severe aplastic anemia post BTN162b2 mRNA COVID-19 vaccination in patient undergoing dialysis. The pathogenesis and risk factors for post-vacci... | 10.11406/rinketsu.64.461 | 37,407,467 | D006801:Humans; D000741:Anemia, Aplastic; D000086663:COVID-19 Vaccines; D000086382:COVID-19; D006435:Renal Dialysis; D014611:Vaccination | [Rinsho ketsueki] The Japanese journal of clinical hematology | 2,023 | D000086663:COVID-19 Vaccines |
Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. | To search for a mammalian homologue of ATX1, a human liver cDNA library was screened and a cDNA clone was isolated, which encodes a protein with 47% amino acid identity to Atx1p including conservation of the MTCXGC copper-binding domain. RNA blot analysis using this cDNA identified an abundant 0.5-kilobase mRNA in all ... | 10.1074/jbc.272.14.9221 | 9,083,055 | D000595:Amino Acid Sequence; D001483:Base Sequence; D015139:Blotting, Southern; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D002871:Chromosome Banding; D003300:Copper; D000079922:Copper Transport Proteins; D005656:Fungal Proteins; D015723:Gene Library; D005816:Genetic Complementation Test; D006706:Home... | The Journal of biological chemistry | 1,997 | C474500:ATOX1 protein, human; C093341:ATX1 protein, S cerevisiae; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D000079922:Copper Transport Proteins; D005656:Fungal Proteins; D056511:Metallochaperones; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins; D003300:Copper |
Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2. | Cyclopentenone prostaglandins (PGs) have antiproliferative activity on various tumor cell growth in vitro. Particularly, 9-deoxy-delta(9,12)-13,14-dihydro PGD(2) (delta(12)-PGJ(2)) was reported for its antineoplastic and apoptotic effects on various cancer cells, but its mechanism inducing apoptosis is still not clear.... | 10.1038/emm.2003.40 | 14,508,070 | D017209:Apoptosis; D020169:Caspases; D045304:Cytochromes c; D006367:HeLa Cells; D006801:Humans; D016328:NF-kappa B; D015230:Prostaglandin D2; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor | Experimental & molecular medicine | 2,003 | C097240:15-deoxy-delta(12,14)-prostaglandin J2; D016328:NF-kappa B; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor; D045304:Cytochromes c; D020169:Caspases; D015230:Prostaglandin D2 |
Study on the multivariate prediction model and exposure level of indoor and outdoor particulate concentration in severe cold region of China. | Atmospheric particulate matter( PM10, PM2.5) has been the main pollutant in most cities of China in recent years, and the exposure concentration is related to the incidence of human diseases and mortality. The time spent indoors is more than 80% for modern people. Therefore, study on the correlation and exposure level ... | 10.1016/j.ecoenv.2018.12.031 | 30,580,165 | D000393:Air Pollutants; D016902:Air Pollution, Indoor; D002681:China; D003080:Cold Temperature; D004781:Environmental Exposure; D005260:Female; D006798:Housing; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D052638:Particulate Matter; D025341:Principal Component Analysis; D056152:R... | Ecotoxicology and environmental safety | 2,019 | D000393:Air Pollutants; D052638:Particulate Matter |
Mutation affecting plasmolysis in Escherichia coli. | A temperature-sensitive mutant of Escherichia coli is described that at the restrictive temperature has lost the ability to plasmolyze. The mutation is located near pyrF. | 10.1128/jb.110.2.789-790.1972 | 4,553,849 | D002463:Cell Membrane Permeability; D002874:Chromosome Mapping; D003470:Culture Media; D004926:Escherichia coli; D006358:Hot Temperature; D009153:Mutagens; D009154:Mutation; D009604:Nitrosoguanidines; D011523:Protoplasts; D011995:Recombination, Genetic; D012965:Sodium Chloride; D013395:Sucrose; D014161:Transduction, Ge... | Journal of bacteriology | 1,972 | D003470:Culture Media; D009153:Mutagens; D009604:Nitrosoguanidines; D012965:Sodium Chloride; D013395:Sucrose |
Local anesthetics as adjuvant analgesics. | Local anesthetics administered to block nerve conduction for surgical anesthesia and to provide analgesia in management of acute pain have become a standard of anesthesiology practice. These drugs have had an important role in the multimodality management of chronic pain as well, and this role is expanding since the re... | 10.1016/0885-3924(94)90110-4 | 7,531,734 | D000277:Adjuvants, Pharmaceutic; D000700:Analgesics; D000779:Anesthetics, Local; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D006801:Humans; D010166:Palliative Care | Journal of pain and symptom management | 1,994 | D000277:Adjuvants, Pharmaceutic; D000700:Analgesics; D000779:Anesthetics, Local |
Concentration of tumour markers CEA, AFP, alpha and beta subunits of hCG in cerebrospinal fluid in children with inflammatory diseases of the central nervous system. | Carcinoembryonic antigen (CEA), alphafetoprotein (AFP) and alpha-beta subunits of human chorionic gonadotropin (hCG) were determined by radio-immunoassay in CSF of 83 children presenting some central nervous disease and compared to the corresponding values obtained in 88 children without neuroinfection. CEA and alpha h... | 2,428,388 | D000293:Adolescent; D002272:Carcinoembryonic Antigen; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D015292:Glycoprotein Hormones, alpha Subunit; D006801:Humans; D008581:Meningitis; D008590:Meningoencephalitis; D010446:Peptide Fragments; D0... | Acta paediatrica Hungarica | 1,986 | D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D015292:Glycoprotein Hormones, alpha Subunit; D010446:Peptide Fragments; D010908:Pituitary Hormones, Anterior; D000509:alpha-Fetoproteins | |
Corticosteroids for the treatment of respiratory infection by Mycoplasma pneumoniae in children: A cost-utility analysis. | INTRODUCTION
Increasing evidence has demonstrated the effectiveness and safety of corticosteroids in community-acquired pneumonia in children. More economic evaluations incorporating the new evidence and in the pediatric population are needed to know the efficiency of this treatment. This study aimed to evaluate the co... | 10.1002/ppul.26592 | 37,431,973 | Pediatric pulmonology | 2,023 | ||
A turn-on fluorescent probe with a dansyl fluorophore for hydrogen sulfide sensing. | Hydrogen sulfide (H2S) is a biologically relevant molecule that has been newly identified as a gasotransmitter and is also a toxic gaseous pollutant. In this study, we report on a metal complex fluorescent probe to achieve the sensitive detection of H2S in a fluorescent "turn-on" mode. The probe bears a dansyl fluoroph... | 10.1039/c9ra04790e | 35,529,213 | RSC advances | 2,019 | ||
Ca2 PbGa8 O15 : Rational Design, Synthesis, and Structure Determination of a Purely Tetrahedra-Based Intergrowth Oxide. | Intergrowth oxides, like Aurivillius, Ruddlesden-Popper phase, comprise functional layers and exhibit interesting physical properties. The hitherto known intergrowth structures mainly were composed of closed-packing of oxygen ions, and it is very challenging to develop new types of intergrowth structures. We proposed t... | 10.1002/anie.201901373 | 30,854,778 | Angewandte Chemie (International ed. in English) | 2,019 | ||
Evaluation of nalbuphine, butorphanol and morphine in dogs during ovariohysterectomy and on early postoperative pain. | OBJECTIVE
To evaluate the effects of nalbuphine, butorphanol and morphine combined with acepromazine on intraoperative and early postoperative pain management in dogs anesthetized for ovariohysterectomy.
STUDY DESIGN
Prospective, randomized blinded clinical study.
ANIMALS
A total of 48 healthy female dogs of differ... | 10.1016/j.vaa.2020.07.035 | 32,891,492 | D000701:Analgesics, Opioid; D000818:Animals; D002077:Butorphanol; D004285:Dogs; D005260:Female; D007044:Hysterectomy; D009020:Morphine; D009266:Nalbuphine; D010052:Ovariectomy; D010149:Pain, Postoperative; D011446:Prospective Studies; D016037:Single-Blind Method | Veterinary anaesthesia and analgesia | 2,020 | D000701:Analgesics, Opioid; D009020:Morphine; D009266:Nalbuphine; D002077:Butorphanol |
Unravelling the hidden ancestry of American admixed populations. | The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events. Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variety of American, European ... | 10.1038/ncomms7596 | 25,803,618 | D044467:American Indian or Alaska Native; D044466:Asian People; D044383:Black People; D002489:Central America; D030541:Databases, Genetic; D004641:Emigration and Immigration; D005828:Genetics, Population; D015894:Genome, Human; D063426:Human Migration; D006801:Humans; D009656:North America; D020641:Polymorphism, Single... | Nature communications | 2,015 | |
Expression Profile of New Marker Genes Involved in Differentiation of Human Wharton's Jelly-Derived Mesenchymal Stem Cells into Chondrocytes, Osteoblasts, Adipocytes and Neural-like Cells. | Wharton's jelly (WJ) contains mesenchymal stem cells (MSCs) exhibiting broad immunomodulatory properties and differentiation capacity, which makes them a promising tool for cellular therapies. Although the osteogenic, chondrogenic and adipogenic differentiation is a gold standard for proper identification of MSCs, it i... | 10.3390/ijms241612939 | 37,629,120 | D006801:Humans; D059631:Wharton Jelly; D019902:Chondrocytes; D017667:Adipocytes; D002454:Cell Differentiation; D010006:Osteoblasts; D007155:Immunologic Factors; D005768:Gastrointestinal Hormones; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived | International journal of molecular sciences | 2,023 | D007155:Immunologic Factors; C467610:PROK1 protein, human; D005768:Gastrointestinal Hormones; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived |
Study of a First Approach to the Controlled Fermentation for Lambic Beer Production. | Non-Saccharomyces yeasts represent a great source of biodiversity for the production of new beer styles, since they can be used in different industrial areas, as pure culture starters, in co-fermentation with Saccharomyces, and in spontaneous fermentation (lambic and gueuze production, with the main contribution of Bre... | 10.3390/microorganisms11071681 | 37,512,854 | Microorganisms | 2,023 | ||
Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism. | Nitrate is a dominant form of inorganic nitrogen (N) in soils and can be efficiently assimilated by bacteria, fungi and plants. We studied here the transcriptome of the short-term nitrate response using assimilating and non-assimilating strains of the model ascomycete Aspergillus nidulans. Among the 72 genes positively... | 10.1111/j.1365-2958.2010.07363.x | 20,969,648 | D027321:Anion Transport Proteins; D001233:Aspergillus nidulans; D005656:Fungal Proteins; D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal; D050901:Nitrate Reductase; D000091285:Nitrate Transporters; D009566:Nitrates; D009569:Nitric Oxide; D009572:Nitrite Reductases | Molecular microbiology | 2,010 | D027321:Anion Transport Proteins; D005656:Fungal Proteins; D000091285:Nitrate Transporters; D009566:Nitrates; D009569:Nitric Oxide; D009572:Nitrite Reductases; D050901:Nitrate Reductase |
Challenges in Dengue Vaccines Development: Pre-existing Infections and Cross-Reactivity. | Dengue is one of the most frequently transmitted mosquito-borne diseases in the world, which creates a significant public health concern globally, especially in tropical and subtropical countries. It is estimated that more than 390 million people are infected with dengue virus each year and around 96 million develop cl... | 10.3389/fimmu.2020.01055 | 32,655,548 | D056704:Adaptive Immunity; D019067:Antibody-Dependent Enhancement; D003429:Cross Reactions; D003715:Dengue; D053059:Dengue Vaccines; D003716:Dengue Virus; D000076722:Drug Development; D005416:Flavivirus; D000076662:Host Microbial Interactions; D006801:Humans; D007113:Immunity, Innate; D018448:Models, Immunological; D01... | Frontiers in immunology | 2,020 | D053059:Dengue Vaccines |
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