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Treatment of severe Kaposiform lymphangiomatosis positive for NRAS mutation by MEK inhibition. | BACKGROUND
Kaposiform lymphangiomatosis (KLA) is a complex lymphatic anomaly involving most commonly the mediastinum, lung, skin and bones with few effective treatments. In recent years, RAS-MAPK pathway mutations were shown to underlie the pathogenesis of several complex lymphatic anomalies. Specifically, an activatin... | 10.1038/s41390-022-01986-0 | 35,246,606 | D002648:Child; D006801:Humans; D042783:Endothelial Cells; D019869:Phosphatidylinositol 3-Kinases; D009154:Mutation; D016896:Treatment Outcome; D044148:Lymphatic Abnormalities; D020929:Mitogen-Activated Protein Kinase Kinases; D008565:Membrane Proteins; D020558:GTP Phosphohydrolases | Pediatric research | 2,023 | D019869:Phosphatidylinositol 3-Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; C579846:NRAS protein, human; D008565:Membrane Proteins; D020558:GTP Phosphohydrolases |
Dynamic severe mitral regurgitation on hospital arrival as prognostic predictor in patients hospitalized for acute decompensated heart failure. | BACKGROUND
Severe mitral regurgitation (MR) on hospital arrival at the onset of acute decompensated heart failure (ADHF) can improve after ADHF treatment because MR is dynamic in nature. This study investigated the clinical significance of the dynamic severe MR on hospital arrival in ADHF patients.
METHODS
Transthora... | 10.1016/j.ijcard.2018.09.093 | 30,274,752 | D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure; D006760:Hospitalization; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D012720:Severity of Illness Index | International journal of cardiology | 2,018 | |
Generating finances for the chemotherapy of children with cancer. | BACKGROUND
To develop and evaluate a system of obtaining financial assistance for the treatment of children with solid tumours by involving individual members of society.
METHODS
This prospective project was carried out at the Paediatric Solid Tumours Clinic of the Department of Paediatric Surgery, All India Institut... | 10,835,858 | D000970:Antineoplastic Agents; D002648:Child; D005653:Fund Raising; D017048:Health Care Costs; D006801:Humans; D007194:India; D009369:Neoplasms; D015397:Program Evaluation; D011446:Prospective Studies | The National medical journal of India | 2,000 | D000970:Antineoplastic Agents | |
A Wiener-type neuronal model in the presence of exponential refractoriness. | An instantaneous return process in the presence of random refractoriness for Wiener model of single neuron activity is considered. The case of exponential distributed refractoriness is analyzed and expressions for output distributions and interspike intervals density are obtained in closed form. A computational study i... | 10.1016/j.biosystems.2006.07.010 | 17,207,918 | D000200:Action Potentials; D000818:Animals; D004594:Electrophysiology; D008433:Mathematics; D008959:Models, Neurological; D009474:Neurons; D049490:Systems Biology | Bio Systems | 2,007 | |
What shapes GPs' work with depressed patients? A qualitative interview study. | BACKGROUND
The ways that GPs treat depressed patients have been criticized in a number of studies.
OBJECTIVE
To explore factors that shape how GPs work with depressed patients.
METHODS
Seventeen GPs from the county of Orebro, Sweden participated in a qualitative semi-structured interview study. GPs' conceptions of ... | 10.1093/fampra/19.6.623 | 12,429,665 | D000328:Adult; D003866:Depressive Disorder; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D010821:Physicians, Family; D010818:Practice Patterns, Physicians'; D013548:Sweden | Family practice | 2,002 | |
In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes. | Eukaryotic cells contain membrane-less organelles, including nucleoli and stress granules, that behave like liquid droplets. Such endogenous condensates often have internal substructure, but how this is established in the absence of membrane encapsulation remains unclear. We find that the N- and C-terminal domains of T... | 10.1016/j.celrep.2016.06.088 | 27,452,472 | D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus; D003594:Cytoplasmic Granules; D004268:DNA-Binding Proteins; D011992:Endosomes; D057809:HEK293 Cells; D006801:Humans; D008322:Mammals; D008566:Membranes; D019636:Neurodegenerative Diseases; D017354:Point Mutation; D012261:Ribonucleoproteins | Cell reports | 2,016 | D004268:DNA-Binding Proteins; D012261:Ribonucleoproteins |
No Useful Field Expansion with Full-field Prisms. | SIGNIFICANCE
Full-field prisms that fill the entire spectacle eye wire have been considered as field expansion devices for homonymous hemianopia (HH) and acquired monocular vision (AMV). Although the full-field prism is used for addressing binocular dysfunction and for prism adaptation training after brain injury as tr... | 10.1097/OPX.0000000000001271 | 30,169,356 | D005139:Eyeglasses; D005403:Fixation, Ocular; D006423:Hemianopsia; D006801:Humans; D008297:Male; D008875:Middle Aged; D014787:Vision Tests; D015348:Vision, Binocular; D015349:Vision, Monocular; D014785:Vision, Ocular; D058609:Visual Field Tests; D014794:Visual Fields | Optometry and vision science : official publication of the American Academy of Optometry | 2,018 | |
Morphological changes in the rat sublingual gland parenchyma with aging. | BACKGROUND
The characteristics of mucous cells in the aging rat sublingual gland were investigated in this study. Particular attention was paid to accumulated amyloid protein and changes of the properties of the secretory granules at the histochemical and ultrastructural level.
OBJECTIVE
This study was designed to ex... | 10.1159/000096098 | 17,033,193 | D000375:Aging; D000682:Amyloid; D000818:Animals; D017209:Apoptosis; D020287:In Situ Nick-End Labeling; D008297:Male; D008854:Microscopy, Electron; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D022142:Secretory Vesicles; D013361:Sublingual Gland | Gerontology | 2,007 | D000682:Amyloid |
Novel features for capturing temporal variations of rhythmic limb movement to distinguish convulsive epileptic and psychogenic nonepileptic seizures. | OBJECTIVE
To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNE... | 10.1111/epi.14619 | 30,536,390 | D061725:Accelerometry; D000328:Adult; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004827:Epilepsy; D005260:Female; D006801:Humans; D008297:Male; D009068:Movement; D012640:Seizures; D013997:Time Factors; D000076251:Wearable Electronic Devices; D014953:Wrist; D055815:Young Adult | Epilepsia | 2,019 | |
A tactile sensor using the acoustic reflection principle for assessing the contact force component in laparoscopic tumor localization. | PURPOSE
Localization of an early stage gastric tumor is easily performed in conventional open surgery, whereas it is a difficult procedure in minimally invasive surgery (MIS). A tactile sensor could allow precise resection of the tumor in laparoscopic surgery. The safety of medical tools should be ensured in MIS. Moreo... | 10.1007/s11548-020-02294-w | 33,389,604 | D000162:Acoustics; D006801:Humans; D010535:Laparoscopy; D055595:Mechanical Phenomena; D019060:Minimally Invasive Surgical Procedures; D009369:Neoplasms; D010173:Palpation; D013270:Stomach; D013274:Stomach Neoplasms; D014110:Touch | International journal of computer assisted radiology and surgery | 2,021 | |
The roles of sex steroid receptor coregulators in cancer. | Sex steroid hormones, estrogen, progesterone and androgen, play pivotal roles in sex differentiation and development, and in reproductive functions and sexual behavior. Studies have shown that sex steroid hormones are the key regulators in the development and progression of endocrine-related cancers, especially the can... | 10.1186/1476-4598-1-7 | 12,473,178 | D000728:Androgens; D000818:Animals; D004967:Estrogens; D005260:Female; D006728:Hormones; D006801:Humans; D008297:Male; D009369:Neoplasms; D011374:Progesterone; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Recep... | Molecular cancer | 2,002 | D000728:Androgens; D004967:Estrogens; D006728:Hormones; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D014157:Transcription Factors; C405423:steroid receptor RNA activator; D011374:Progestero... |
Better functional outcome after single-radius TKA compared with multi-radius TKA. | PURPOSE
To determine whether the design of the femoral component influenced patient outcomes.
METHODS
Two hundred and thirty-seven patients were randomized to compare functional outcomes between single-radius TKA (SR, 118 patients) and multi-radius TKA (MR, 119 patients) with a minimum follow-up of 5 years. Prospecti... | 10.1007/s00167-016-4273-0 | 27,522,590 | D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D005269:Femur; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D011474:Prosthesis Design; D016059:Range of Motion, ... | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA | 2,017 | |
(S)-WAY 100135, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. | Scopolamine, 3.75 micrograms/microliters infused bilaterally into the CA1 region of the dorsal hippocampus 10 min before each training session, impaired choice accuracy but had no effect on choice latency or errors of omission in rats trained in a two-platform spatial discrimination task. Administered subcutaneously at... | 10.1016/0014-2999(95)00310-h | 7,498,302 | D000818:Animals; D004192:Discrimination, Psychological; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus; D007278:Injections, Spinal; D007858:Learning; D008297:Male; D010879:Piperazines; D051381:Rats; D012601:Scopolamine; D012702:Serotonin Antagonists; D013037:Spatial Behavior; D013997:Time Factors | European journal of pharmacology | 1,995 | D010879:Piperazines; D012702:Serotonin Antagonists; C081293:WAY 100135; D012601:Scopolamine |
The CCR4-NOT complex component NOT1 regulates RNA-directed DNA methylation and transcriptional silencing by facilitating Pol IV-dependent siRNA production. | Small interfering RNAs (siRNAs) are responsible for establishing and maintaining DNA methylation through the RNA-directed DNA methylation (RdDM) pathway in plants. Although siRNA biogenesis is well known, it is relatively unclear about how the process is regulated. By a forward genetic screen in Arabidopsis thaliana, w... | 10.1111/tpj.14818 | 32,412,137 | D017360:Arabidopsis; D029681:Arabidopsis Proteins; D019175:DNA Methylation; D012321:DNA-Directed RNA Polymerases; D034741:RNA, Small Interfering; D012097:Repressor Proteins; D014157:Transcription Factors | The Plant journal : for cell and molecular biology | 2,020 | C000715608:AT1G02080 protein, Arabidopsis; D029681:Arabidopsis Proteins; D034741:RNA, Small Interfering; D012097:Repressor Proteins; D014157:Transcription Factors; C499181:RNA polymerase IV, Arabidopsis; D012321:DNA-Directed RNA Polymerases |
Decreased plasma levels of ceruloplasmin after diet-induced weight loss in obese women. | BACKGROUND
Plasma ceruloplasmin (Cp) has been shown to be a risk factor for cardiovascular disease and also to be associated with obesity. However, it is not known whether weight loss could decrease the plasma Cp levels.
AIM
To investigate the effect of diet-induced weight loss on plasma Cp in obese women.
SUBJECTS... | 10.3275/7878 | 21,795,842 | D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein; D002570:Ceruloplasmin; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D009765:Obesity; D015431:Weight Loss | Journal of endocrinological investigation | 2,012 | D002097:C-Reactive Protein; D002570:Ceruloplasmin |
A Systematic Review on Oncology Nurses' Knowledge on Palliative Care. | BACKGROUND
Patients with cancer have high symptom burden and unmet needs and therefore can benefit from palliative care. Oncology nurses are consistent providers of care to patients with cancer and can provide palliative care to these patients. However, oncology nurses' knowledge on palliative care has not been systema... | 10.1097/NCC.0000000000000817 | 32,217,878 | D002983:Clinical Competence; D064946:Hospice and Palliative Care Nursing; D006801:Humans; D009726:Nurses; D010166:Palliative Care; D013727:Terminal Care | Cancer nursing | 2,021 | |
Dense Dilated Deep Multiscale Supervised U-Network for biomedical image segmentation. | Biomedical image segmentation is essential for computerized medical image analysis. Deep learning algorithms allow us to design state-of-the-art models for solving segmentation problems. The U-Net and its variants have provided positive results across various datasets. However, the existing networks have the same recep... | 10.1016/j.compbiomed.2022.105274 | 35,123,135 | Computers in biology and medicine | 2,022 | ||
Correlation Assessment of Climate and Geographic Distribution of Tuberculosis Using Geographical Information System (GIS). | BACKGROUND
Tuberculosis (TB) spread pattern is influenced by geographic and social factors. Nowadays Geographic Information System (GIS) is one of the most important epidemiological instrumentation identifying high-risk population groups and geographic areas of TB. The aim of this study was to determine the correlation... | 27,057,526 | Iranian journal of public health | 2,016 | |||
Ocular manifestations of classical and limited Wegener's granulomatosis. | Wegener's granulomatosis (WG) may be subdivided into two forms, classical and limited. The latter specifically excludes renal disease and carries a better prognosis. Both forms have sight-threatening complications, but the relative incidence of ocular manifestations in each is not well documented. Patients with limited... | 8,265,772 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005128:Eye Diseases; D005260:Female; D014890:Granulomatosis with Polyangiitis; D006801:Humans; D007767:Lacrimal Duct Obstruction; D008297:Male; D008875:Middle Aged; D009301:Nasolacrimal Duct; D009916:Orbital Diseases | The Quarterly journal of medicine | 1,993 | ||
Comparing biological and artificial vision systems: Network measures of functional connectivity. | Advances in Deep Convolutional Neural Networks (DCNN) provide new opportunities for computational neuroscience to pose novel questions regarding the function of biological visual systems. Some attempts have been made to utilize advances in machine learning to answer neuroscientific questions, but how to appropriately m... | 10.1016/j.neulet.2020.135407 | 32,979,459 | D000818:Animals; D003627:Data Interpretation, Statistical; D051379:Mice; D008959:Models, Neurological; D016571:Neural Networks, Computer; D009474:Neurons; D021641:Recognition, Psychology; D014793:Visual Cortex | Neuroscience letters | 2,020 | |
High accuracy 4D cell tracking into explanted skin using two-photon excitation microscopy. | Two-photon excitation microscopy (2PEM) analysis of large explanted organs is still laborious, principally because of tissue movements inducing lateral and axial drifts during extended imaging sessions. Here, we describe a two-step approach to track motile T cells in murine dorsal explanted skin with the best accuracy.... | 10.1002/jemt.22474 | 25,663,489 | D000818:Animals; D058948:Cell Tracking; D007091:Image Processing, Computer-Assisted; D051379:Mice; D008853:Microscopy; D012867:Skin; D012984:Software; D013601:T-Lymphocytes | Microscopy research and technique | 2,015 | |
Correlation of Virtual Reality Simulation and Dry Lab Robotic Technical Skills. | STUDY OBJECTIVE
To examine whether a set of virtual reality (VR) surgical simulation drills have correlative validity when compared with the validated Robotic Objective Structured Assessment of Technical Skills (R-OSATS) dry lab drills.
DESIGN
A prospective methods comparison study (Canadian Task Force classification... | 10.1016/j.jmig.2017.11.006 | 29,154,932 | D000328:Adult; D002983:Clinical Competence; D004521:Educational Measurement; D005180:Faculty, Medical; D005257:Fellowships and Scholarships; D005260:Female; D013502:General Surgery; D006176:Gynecology; D006784:Hospitals, Teaching; D006801:Humans; D007396:Internship and Residency; D008297:Male; D008875:Middle Aged; D009... | Journal of minimally invasive gynecology | 2,018 | |
ToF-SIMS measurements with topographic information in combined images. | In 2D and 3D time-of-flight secondary ion mass spectrometric (ToF-SIMS) analysis, accentuated structures on the sample surface induce distorted element distributions in the measurement. The origin of this effect is the 45° incidence angle of the analysis beam, recording planar images with distortion of the sample surfa... | 10.1007/s00216-013-6850-0 | 23,460,300 | Analytical and bioanalytical chemistry | 2,013 | ||
Financial cost of whole blood and blood component disposals in a Brazilian coordinating blood center. | OBJECTIVE
To describe the reasons for the disposal of blood in the coordinating blood center of the State of Paraná and to estimate the financial costs resulting from potentially avoidable discards.
METHOD
A descriptive, retrospective and documentary analysis, with data related to the period from 2010 to 2015 of a Br... | 10.1590/1983-1447.2019.20190033 | 31,664,326 | D001769:Blood; D001938:Brazil; D003365:Costs and Cost Analysis; D006801:Humans; D017744:Medical Waste Disposal; D012189:Retrospective Studies | Revista gaucha de enfermagem | 2,019 | D017744:Medical Waste Disposal |
The Asian species of strychnos. Part IV. The alkaloids. | Two hundred thirty-four samples from thirty-six Asian species of Strychnos have been screened for the presence of tertiary alkaloids; the data are set out in table 1. Thin-layer and gas-liquid chromatographic as well as mass-spectrometric studies have enabled alkaloids to be identified in many of the extracts prepared;... | 14,294 | D000470:Alkaloids; D001208:Asia; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D013058:Mass Spectrometry; D010946:Plants, Medicinal; D013331:Strychnine | Lloydia | 1,976 | D000470:Alkaloids; D013331:Strychnine | |
Geographical association between livestock density and human Shiga toxin-producing Escherichia coli O157 infections. | Shiga toxin-producing Escherichia coli (STEC) bacteria can cause outbreaks and sporadic cases of gastroenteritis in humans. Ruminants are seen as the main reservoir. The aim of this study was to evaluate the spatial association between reported human STEC O157 infections in The Netherlands and different livestock densi... | 10.1017/S0950268810002050 | 20,822,576 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D002648:Child; D002675:Child, Preschool; D004197:Disease Reservoirs; D004927:Escherichia coli Infections; D019453:Escherichia coli O157; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D0... | Epidemiology and infection | 2,011 | |
Polyalkylcyanoacrylate nanoparticles as polymeric carriers for antisense oligonucleotides. | Adsorption of oligothymidylates on polyisobutyl- or polyisohexylcyanoacrylate nanoparticles was achieved in the presence of hydrophobic cations such as tetraphenylphosphonium chloride or quaternary ammonium salts. Results suggested that oligonucleotide adsorption on the nanoparticles was mediated by the formation of io... | 10.1023/a:1015871809313 | 1,495,887 | D003487:Cyanoacrylates; D004337:Drug Carriers; D016376:Oligonucleotides, Antisense | Pharmaceutical research | 1,992 | D003487:Cyanoacrylates; D004337:Drug Carriers; D016376:Oligonucleotides, Antisense |
A novel LED-based 2D-fluorescence spectroscopy system for in-line bioprocess monitoring of Chinese hamster ovary cell cultivations-Part II. | This study was performed in order to evaluate a new LED-based 2D-fluorescence spectrometer for in-line bioprocess monitoring of Chinese hamster ovary (CHO) cell culture processes. The new spectrometer used selected excitation wavelengths of 280, 365, and 455 nm to collect spectral data from six 10-L fed-batch processes... | 10.1002/elsc.201800146 | 32,625,013 | Engineering in life sciences | 2,019 | ||
An influence of immunomodulation on Th1 and Th2 immune response in endometriosis in an animal model. | AIM
To assess the role of the Th1 and Th2 cellular response in the etiology of endometriosis observed in a rat model, with the use of the RESAN immunomodulator.
MATERIALS AND METHODS
A comparative analysis of cytokines in blood serum typical of Th1 (TNF-α and INF-γ ) and Th2 (IL-4, IL-6, IL-10) cell response in group... | 10.1155/2013/849492 | 24,298,555 | D000818:Animals; D019496:Cancer Vaccines; D004195:Disease Models, Animal; D004715:Endometriosis; D005260:Female; D007155:Immunologic Factors; D056747:Immunomodulation; D007371:Interferon-gamma; D016753:Interleukin-10; D015847:Interleukin-4; D015850:Interleukin-6; D051381:Rats; D017208:Rats, Wistar; D018417:Th1 Cells; D... | BioMed research international | 2,013 | D019496:Cancer Vaccines; D007155:Immunologic Factors; D015850:Interleukin-6; C540762:RESAN vaccine; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma |
Role of laminin and integrin interactions in growth cone guidance. | Laminin is well known to promote neuronal adhesion and axonal growth, but recent experiments suggest laminin has a wider role in guiding axons, both in development and regeneration. In vitro experiments demonstrate that laminin can alter the rate and direction of axonal growth, even when growth cone contact with lamini... | 10.1007/BF02740648 | 8,818,145 | D000818:Animals; D001369:Axons; D002448:Cell Adhesion; D002450:Cell Communication; D002455:Cell Division; D006801:Humans; D016023:Integrins; D007797:Laminin; D009416:Nerve Regeneration; D009474:Neurons; D017474:Receptors, Laminin; D012165:Retinal Ganglion Cells | Molecular neurobiology | 1,996 | D016023:Integrins; D007797:Laminin; D017474:Receptors, Laminin |
Vascular factors in the neurotoxic damage caused by 1,3-dinitrobenzene in the rat. | Using a 3 x 10 mg/kg dose schedule of 1,3-dinitrobenzene (DNB) over two days in Fischer rats, we have found the following changes in vascular function and structure during the early phase of the symmetrical brain stem lesions. 1. Marked increase in cerebral blood flow generally but especially in the inferior colliculi,... | 10.1111/j.1365-2990.1991.tb00752.x | 1,800,913 | D000818:Animals; D001927:Brain Diseases; D001933:Brain Stem; D002543:Cerebral Hemorrhage; D002560:Cerebrovascular Circulation; D004136:Dinitrobenzenes; D006735:Horseradish Peroxidase; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344 | Neuropathology and applied neurobiology | 1,991 | D004136:Dinitrobenzenes; C017906:3-dinitrobenzene; D006735:Horseradish Peroxidase |
Membrane thickness and acyl chain length. | It appears reasonable to expect that the primary result of a change in the length of the acyl chains within a lipid bilayer is a similar change in the bilayer thickness. In the present communication we draw attention to the somewhat more complicated effects which are found experimentally for phosphatidylcholine bilayer... | 10.1016/0005-2736(83)90106-2 | 6,882,754 | D005227:Fatty Acids; D008051:Lipid Bilayers; D008968:Molecular Conformation; D010713:Phosphatidylcholines; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction | Biochimica et biophysica acta | 1,983 | D005227:Fatty Acids; D008051:Lipid Bilayers; D010713:Phosphatidylcholines |
A mutant yeast deficient in Golgi transport of uridine diphosphate N-acetylglucosamine. | Mannan chains of Kluyveromyces lactis mannoproteins are similar to those of Saccharomyces cerevisiae except that they have terminal alpha1-->2-linked N-acetylglucosamine and lack mannose phosphate. In a previous study, Douglas and Ballou (Douglas, R. K., and Ballou, C. E. (1982) Biochemistry 21, 1561-1570) characterize... | 10.1074/jbc.271.15.8851 | 8,621,525 | D001692:Biological Transport; D005656:Fungal Proteins; D005800:Genes, Fungal; D006017:Glycolipids; D006056:Golgi Apparatus; D007716:Kluyveromyces; D008562:Membrane Glycoproteins; D009154:Mutation; D013696:Temperature; D014537:Uridine Diphosphate N-Acetylglucosamine | The Journal of biological chemistry | 1,996 | D005656:Fungal Proteins; D006017:Glycolipids; D008562:Membrane Glycoproteins; C025363:mannoproteins; D014537:Uridine Diphosphate N-Acetylglucosamine |
A review of analytical methods for the determination of sulfolane and alkanolamines in environmental studies. | Sulfolane and alkanolamines are used extensively in the processing of sour natural gases. Over many years of operation, there have been inadvertent leaks of these chemicals to groundwater and wetlands surrounding gas processing facilities, leading to uptake by vegetation. Because sulfolane and alkanolamines are extreme... | 11,878,596 | D000588:Amines; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002849:Chromatography, Gas; D004785:Environmental Pollutants; D012997:Solvents; D013876:Thiophenes | Journal of AOAC International | 2,002 | D000588:Amines; D004785:Environmental Pollutants; D012997:Solvents; D013876:Thiophenes; C013693:sulfolane | |
Microbiological aetiology, epidemiology, and clinical profile of prosthetic joint infections: are current antibiotic prophylaxis guidelines effective? | Prosthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as a surgical antibiotic prophylaxis at the time of arthroplasty. This retrospective cohort study conducted across 10 hospitals over a 3-year period (January 2006 to December 2008)... | 10.1128/AAC.06246-11 | 22,314,530 | D000368:Aged; D000900:Anti-Bacterial Agents; D019072:Antibiotic Prophylaxis; D001178:Arthroplasty; D001315:Australia; D002437:Cefazolin; D024881:Drug Resistance, Bacterial; D016983:Enterococcus; D005260:Female; D006020:Glycopeptides; D006090:Gram-Negative Bacteria; D006615:Hip; D006801:Humans; D007595:Joint Prosthesis;... | Antimicrobial agents and chemotherapy | 2,012 | D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D002437:Cefazolin |
Venous thromboembolism secondary to uterine fibroids: a case of phlegmasia cerulea dolens and review of the literature. | Uterine fibroids are usually benign soft tissue tumors, however, when they become large, they can cause external venous compression. We present a case of a 45-year-old woman who presented with phlegmasia cerulea dolens from a large uterine fibroid. She was successfully treated with hysterectomy, venous thrombectomy, an... | 25,463,329 | D005260:Female; D006801:Humans; D007889:Leiomyoma; D008875:Middle Aged; D013924:Thrombophlebitis; D014594:Uterine Neoplasms; D054556:Venous Thromboembolism | Annals of vascular surgery | 2,015 | ||
The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. | OBJECTIVE
Both the ischemia-reperfusion injury and the abnormal changes of redox status are the important pathologic changes in the burn shock stage for severe burns. The study of clinical dynamic, quantitative relevance about them was performed.
METHODS
In this study, blood redox potential (ORP) values (ΔORP value w... | 25,552,460 | D000328:Adult; D002056:Burns; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D006400:Hematocrit; D006801:Humans; D000860:Hypoxia; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D015427:Reperfusion Injury; D012189:Retrosp... | The American journal of emergency medicine | 2,015 | D014527:Uric Acid; D019344:Lactic Acid | |
Analysis of the reliability of the modified caregiver strain index. | OBJECTIVES
The Caregiver Strain Index (CSI) is a 13-item index originally developed in the early 1980s to screen for caregiver strain after hospital discharge of an elderly family member. This study examined the reliability of a modified CSI for applications with contemporary long-term family caregivers.
METHODS
As p... | 10.1093/geronb/58.2.s127 | 12,646,602 | D000368:Aged; D017028:Caregivers; D005006:Ethnicity; D005260:Female; D017144:Focus Groups; D006801:Humans; D008297:Male; D008875:Middle Aged; D008913:Minority Groups; D010351:Patient Discharge; D013315:Stress, Psychological | The journals of gerontology. Series B, Psychological sciences and social sciences | 2,003 | |
Cardiopulmonary exercise testing determination of functional capacity in mitral regurgitation: physiologic and outcome implications. | OBJECTIVES
This study was designed to evaluate prevalence, determinants, and clinical outcome implications of reduced functional capacity (FC) in patients with organic mitral regurgitation (MR).
BACKGROUND
Evaluation of FC by exercise testing is rarely performed in MR because little is known about the clinical determ... | 10.1016/j.jacc.2006.02.043 | 16,781,383 | D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency; D011379:Prognosis; D011446:Prospective Studies | Journal of the American College of Cardiology | 2,006 | |
Selective localization of intravenously injected 111indium-labelled eosinophils in rat tissues infected with Nippostrongylus brasiliensis. | 111Indium-oxine-labelled rat eosinophils were injected i.v. into rats infected with Nippostrongylus brasiliensis and controls. Radionuclide imaging was done to measure the rate and extent of radioactive uptake into different regions of the body in vivo. Radioactivity appeared first in the lungs then in the livers and s... | 10.1111/j.1365-3024.1983.tb00733.x | 6,405,361 | D000818:Animals; D004804:Eosinophils; D007204:Indium; D007420:Intestine, Large; D007421:Intestine, Small; D008099:Liver; D008168:Lung; D009349:Nematode Infections; D009559:Nippostrongylus; D009942:Organometallic Compounds; D015125:Oxyquinoline; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D011919:... | Parasite immunology | 1,983 | D009942:Organometallic Compounds; D011868:Radioisotopes; D007204:Indium; C032950:indium oxine; D015125:Oxyquinoline |
Psychrotrophic bacteria isolated from a constantly warm tropical environment. | Psychrotrophic bacteria are known to occur in temperate, constantly cold, and artificially cooled environments. This is the first report of their occurrence in a constantly warm (ca. 24 degrees-35 degrees C) tropical environment. Soil samples taken from two sites along the southeastern coastal zone of Jamaica yielded g... | 10.1007/pl00006758 | 9,516,542 | D000222:Adaptation, Physiological; D001407:Bacillus; D001419:Bacteria; D003081:Cold Climate; D006090:Gram-Negative Bacteria; D016987:Gram-Positive Rods; D013696:Temperature; D014329:Tropical Climate | Current microbiology | 1,998 | |
Perceived quality of life of adults with developmental and other significant disabilities. | PURPOSE
The purpose of this qualitative study was to describe the perceived quality of life (PQOL) of adults with significant disabilities who were living in community settings.
METHODS
Six male and six female volunteers (mean age 48 years, standard deviation 14 years), half with developmental and half with acquired ... | 10.1080/0963828031000148638 | 12,944,149 | D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D002658:Developmental Disabilities; D006233:Disabled Persons; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life | Disability and rehabilitation | 2,003 | |
Implementation of a quality improvement programme to support advance care planning in five hospitals across a health region. | OBJECTIVES
Advance care planning (ACP) can help patients with a terminal illness to prepare for the end of their lives. This report describes a regional service improvement initiative to increase the identification of hospital inpatients at this stage in their illnesses and to increase the number of such patients who a... | 10.1136/bmjspcare-2013-000574 | 24,644,209 | D032722:Advance Care Planning; D004608:Eligibility Determination; D006284:Health Plan Implementation; D006761:Hospitals; D006801:Humans; D007297:Inpatients; D008131:London; D015397:Program Evaluation; D011446:Prospective Studies; D058996:Quality Improvement | BMJ supportive & palliative care | 2,015 | |
How could molecular biology modify the management of upper urinary tract tumours? | BACKGROUND
Upper urinary tract urothelial carcinomas (UUT-UCs) account for only 5-10% of urothelial carcinomas and the gold standard treatment is open radical nephroureterectomy. Strong differences exist regarding tumor behaviour between the upper and the lower urinary tract.
OBJECTIVE
To demonstrate how the current ... | 23,793,771 | D000818:Animals; D063646:Carcinogenesis; D020022:Genetic Predisposition to Disease; D006801:Humans; D008967:Molecular Biology; D011110:Polymorphism, Genetic; D014571:Urologic Neoplasms; D014572:Urology | Archivos espanoles de urologia | 2,013 | ||
Collapse of a lipid-coated nanobubble and subsequent liposome formation. | We investigate the collapse of a lipid-coated nanobubble and subsequent formation of a lipid vesicle by coarse grained molecular dynamics simulations. A spherical nanobubble coated with a phospholipid monolayer in water is a model of an aqueous dispersion of phospholipids under negative pressure during sonication. When... | 10.1038/srep28164 | 27,306,704 | D008081:Liposomes; D056004:Molecular Dynamics Simulation; D010743:Phospholipids; D011312:Pressure; D013010:Sonication | Scientific reports | 2,016 | D008081:Liposomes; D010743:Phospholipids |
Territorial aggression does not feed back on testosterone in a multiple-brooded songbird species with breeding and non-breeding season territoriality, the European stonechat. | Testosterone mediates reproductive behaviours in male vertebrates. For example, breeding season territoriality depends on testosterone in many species of birds and in some, territorial interactions feed back on testosterone concentrations. However, the degree to which territorial behaviour and testosterone are associat... | 10.1016/j.yhbeh.2016.11.002 | 27,838,361 | D000374:Aggression; D000728:Androgens; D000818:Animals; D001522:Behavior, Animal; D025461:Feedback, Physiological; D007987:Gonadotropin-Releasing Hormone; D008297:Male; D012098:Reproduction; D012621:Seasons; D020308:Songbirds; D013731:Territoriality; D013739:Testosterone | Hormones and behavior | 2,017 | D000728:Androgens; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone |
Impact of a Novel Hypothermia Alert Device on Death of Low Birthweight Babies at Four Weeks: A Non-randomized Controlled Community-based Trial. | OBJECTIVE
To study the effectiveness of a hypothermia monitoring device in reducing neonatal mortality and increasing Kangaroo Mother Care compliance.
DESIGN
Non-randomized controlled trial.
SETTING
3 government Sick Newborn Care Units and 7 Primary Health Centers in Udaipur and Dungarpur districts of Rajasthan for... | 32,038,035 | D001724:Birth Weight; D002648:Child; D006801:Humans; D007035:Hypothermia; D007194:India; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D060127:Kangaroo-Mother Care Method | Indian pediatrics | 2,020 | ||
Acrolein - a pulmonary hazard. | Acrolein is a respiratory irritant that can be generated during cooking and is in environmental tobacco smoke. More plentiful in cigarette smoke than polycyclic aromatic hydrocarbons (PAH), acrolein can adduct tumor suppressor p53 (TP53) DNA and may contribute to TP53-mutations in lung cancer. Acrolein is also generate... | 10.1002/mnfr.201100279 | 21,994,168 | D000171:Acrolein; D000818:Animals; D017209:Apoptosis; D001249:Asthma; D001991:Bronchitis; D003296:Cooking; D018736:DNA Adducts; D005786:Gene Expression Regulation; D006801:Humans; D008175:Lung Neoplasms; D029424:Pulmonary Disease, Chronic Obstructive; D023382:Toxicity Tests, Acute; D016159:Tumor Suppressor Protein p53 | Molecular nutrition & food research | 2,011 | D018736:DNA Adducts; D016159:Tumor Suppressor Protein p53; D000171:Acrolein |
Single-incision thoracoscopic surgery using a chest wall pulley for lung excision in patients with primary spontaneous pneumothorax. | PURPOSE
The aim of the study was to evaluate the feasibility and compare the outcomes of single-incision thoracoscopic surgery using a chest wall pulley for lung excision (PulLE) vs. those of conventional video-assisted thoracic surgery (cVATS) in patients with primary spontaneous pneumothorax (PSP).
METHODS
Sixty-ni... | 10.1007/s00595-014-0992-3 | 25,059,347 | D000293:Adolescent; D000328:Adult; D004322:Drainage; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D061646:Operative Time; D011013:Pneumonectomy; D011030:Pneumothorax; D011184:Postoperative Period; D012008:Recurrence; D012189:Retrospective Studies; D020775:Thoracic Surgery, Video-Assisted; D0139... | Surgery today | 2,015 | |
Transcatheter treatment of functional mitral valve regurgitation. | Functional mitral regurgitation is a clinical entity with increasing prevalence and significant impact on morbidity and mortality. Because of the unsatisfactory results of medical therapy and high perioperative risk resulting in low referral/high denial rates for surgical treatment, benefits of which still remain contr... | 10.1016/j.tcm.2020.10.006 | 33,069,900 | D006328:Cardiac Catheterization; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008943:Mitral Valve; D008944:Mitral Valve Insufficiency; D016896:Treatment Outcome | Trends in cardiovascular medicine | 2,021 | |
Impact of a National Quality Collaborative on Pediatric Asthma Care Quality by Insurance Status. | OBJECTIVE
To assess whether disparities in asthma care and outcomes based on insurance type existed before a national quality improvement (QI) collaborative, and to determine the effects of the collaborative on these disparities.
METHODS
Secondary analysis of data from Pathways for Improving Pediatric Asthma Care (PI... | 10.1016/j.acap.2021.02.009 | 33,607,330 | D001249:Asthma; D002648:Child; D004636:Emergency Service, Hospital; D006760:Hospitalization; D006801:Humans; D019458:Insurance Coverage; D011787:Quality of Health Care | Academic pediatrics | 2,021 | |
Physical Activity Interventions Among American Indian and Alaska Native Persons: A Systematic Review. | OBJECTIVE
The purpose of this review was to identify and describe physical activity (PA) interventions that have been implemented with American Indian and Alaska Natives (AIANs) in the U.S. and Canada since 2006.
DATA SOURCE
Searches were conducted in 8 databases plus grey literature sources.
STUDY INCLUSION AND EX... | 10.1177/08901171221097687 | 35,499,982 | D000293:Adolescent; D002648:Child; D000328:Adult; D006801:Humans; D000072957:Alaskan Natives; D007198:Indians, North American; D015444:Exercise; D002170:Canada | American journal of health promotion : AJHP | 2,022 | |
Survival and prognostic factors after adjuvant 131iodine-labeled lipiodol for hepatocellular carcinoma: a retrospective analysis of 106 patients over 20 years. | OBJECTIVE
Hepatocellular carcinoma (HCC) has high recurrence rate after curative treatment. The aim of the present study was to report our experience with adjuvant use of 131I-lipiodol after curative treatment of HCC in terms of recurrence and survival in a large cohort of patients with a long follow-up.
METHODS
All ... | 10.1007/s12149-017-1165-4 | 28,342,103 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular; D015331:Cohort Studies; D004998:Ethiodized Oil; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012008:... | Annals of nuclear medicine | 2,017 | D007457:Iodine Radioisotopes; D004998:Ethiodized Oil |
Adrenal cortical neoplasms in children: why so many carcinomas and yet so many survivors? | Adrenal cortical neoplasms in children are represented by a disproportionate number of cases that have been diagnosed pathologically as adrenocortical carcinomas (ACCs)-as many as 90% of all cortical tumors in some pediatric series. Like other solid malignancies of childhood, over half of ACCs present in the first 4 ye... | 10.2350/08-06-0489.1 | 19,326,954 | D000306:Adrenal Cortex Neoplasms; D018268:Adrenocortical Carcinoma; D001506:Beckwith-Wiedemann Syndrome; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016864:Li-Fraumeni Syndrome; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D017741:Survivors | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society | 2,009 | |
Rabbit cone bipolar cells: correlation of their morphologies with whole-cell recordings. | The superfused retinal slice preparation was used to examine the morphology and glutamate-activated whole-cell currents of rabbit bipolar cells. There were six morphologically distinct types of cone bipolar cells and a rod bipolar cell that had axon terminals stratifying in stratum 3 to 5 of sublamina-b. All of these b... | 10.1017/s0952523801185019 | 11,925,003 | D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000818:Animals; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D005456:Fluorescent Dyes; D005998:Glycine; D007395:Interneurons; D008856:Microscopy, Fluorescence; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals; D011817:Rabb... | Visual neuroscience | 2,001 | D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D005456:Fluorescent Dyes; D018094:Receptors, Metabotropic Glutamate; D012235:Rhodamines; C104331:cyclopropyl-4-phosphonophenylglycine; C113897:metabotropic glutamate receptor 6; C022027:lissamine rhodamine B; D018750:6-Cyano-7-nitroquino... |
Trade, Diplomacy, and Warfare: The Quest for Elite Rhizobia Inoculant Strains. | Rhizobia form symbiotic nitrogen-fixing nodules on leguminous plants, which provides an important source of fixed nitrogen input into the soil ecosystem. The improvement of symbiotic nitrogen fixation is one of the main challenges facing agriculture research. Doing so will reduce the usage of chemical nitrogen fertiliz... | 10.3389/fmicb.2017.02207 | 29,170,661 | Frontiers in microbiology | 2,017 | ||
An in vitro analysis of intestinal ammonia handling in fasted and fed freshwater rainbow trout (Oncorhynchus mykiss). | Ammonia transport and metabolism were investigated in the intestinal tract of freshwater rainbow trout which had been either fasted for 7 days, or fasted then fed a satiating meal of commercial trout pellets. In vivo, total ammonia concentrations (T amm) in the chyme were approximately 1 mmol L(-1) across the entire in... | 10.1007/s00360-013-0781-0 | 24,043,214 | D000641:Ammonia; D000818:Animals; D005215:Fasting; D029941:Fish Proteins; D005969:Glutamate Dehydrogenase; D005974:Glutamate-Ammonia Ligase; D005972:Glutaminase; D066298:In Vitro Techniques; D007413:Intestinal Mucosa; D017686:Oncorhynchus mykiss | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology | 2,014 | D029941:Fish Proteins; D000641:Ammonia; D005969:Glutamate Dehydrogenase; D005972:Glutaminase; D005974:Glutamate-Ammonia Ligase |
Three-Dimensional-Printed Patient-Specific Osteotomy Guides, Repositioning Guides and Titanium Plates for Acute Correction of Antebrachial Limb Deformities in Dogs. | OBJECTIVE
The aim of this study was to describe the use of patient-specific three-dimensional (3D)-printed osteotomy guides, repositioning guides and custom-printed titanium plates for acute correction of antebrachial limb deformities in four dogs.
METHODS
Retrospective review of antebrachial limb deformities in smal... | 10.1055/s-0040-1709702 | 32,356,295 | D000818:Animals; D001860:Bone Plates; D004283:Dog Diseases; D004285:Dogs; D010027:Osteotomy; D066330:Printing, Three-Dimensional; D011884:Radius; D012189:Retrospective Studies; D014025:Titanium | Veterinary and comparative orthopaedics and traumatology : V.C.O.T | 2,021 | D014025:Titanium |
Sevoflurane exposure in postnatal rats induced long-term cognitive impairment through upregulating caspase-3/cleaved-poly (ADP-ribose) polymerase pathway. | The association of anesthetic exposure in infants or young children with the long-term impairment of neurologic functions has been reported previously; however, the underlying mechanisms remain largely unknown. In order to identify dysregulated gene expression underlying long-term cognitive impairment caused by sevoflu... | 10.3892/etm.2017.5004 | 29,042,986 | Experimental and therapeutic medicine | 2,017 | ||
Temporal evolution of 137Cs, 237Np, and 239+240Pu and estimated vertical 239+240Pu export in the northwestern Mediterranean Sea. | The evolution of 137Cs, 237Np and 239+240Pu at the DYFAMED station (NW Mediterranean) is discussed in relation to physical processes, downward fluxes of particles, and changes in the main input sources. The data set presented in this study represents the first complete 237Np vertical profiles (0.12-0.27μBqL-1), and con... | 10.1016/j.scitotenv.2017.03.137 | 28,384,574 | The Science of the total environment | 2,017 | ||
Chronic congestive heart failure elicits adaptations of endurance exercise in diaphragmatic muscle. | BACKGROUND
During rest and exercise, patients with heart failure hyperventilate; therefore, the diaphragm can be viewed as undergoing constant moderate-intensity exercise. Accordingly, we hypothesized that heart failure elicits adaptations in the diaphragm similar to those elicited by endurance exercise in the limb mus... | 10.1161/01.cir.95.4.910 | 9,054,750 | D015094:3-Hydroxyacyl CoA Dehydrogenases; D000064:Acclimatization; D000328:Adult; D001706:Biopsy; D002950:Citrate (si)-Synthase; D003964:Diaphragm; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006019:Glycolysis; D006333:Heart Failure; D006353:Heart-Assist Devices; D006801:Humans; D007770:L-Lactate Dehydrog... | Circulation | 1,997 | D015094:3-Hydroxyacyl CoA Dehydrogenases; D007770:L-Lactate Dehydrogenase; D002950:Citrate (si)-Synthase; D018995:Myosin Heavy Chains; D009218:Myosins |
T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage. | An acetone-precipitable fraction of Mycobacterium tuberculosis cross-reacts with human cartilage. Immune responses to this antigen were assessed in 34 patients with rheumatoid arthritis, 16 patients with degenerative joint disease, and 15 healthy controls. The RA patients differed from the other two groups in having mo... | 10.1016/s0140-6736(86)90003-6 | 2,874,329 | D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D001172:Arthritis, Rheumatoid; D001666:Binding Sites, Antibody; D002356:Cartilage; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007106:Immune Sera; D066298:In Vitro Techniques; D008213:L... | Lancet (London, England) | 1,986 | D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D007106:Immune Sera; D011509:Proteoglycans |
[New procedure in the diagnosis of maldigestion. Studies with 3-H palmitic acid and 14-C tripalmitate in normal subjects and patients with chronic pancreatitis]. | 3H-palmitic acid and 14C-tripalmitate dissolved in 1.0 g indian corn oil/kg body weight were administered to 29 patients with chronic pancreatitis and 25 control subjects. For the following 8 h 3H and 14C radioactivity in serum lipids and 14CO2 in expired air were measured at 2-hour intervals. Triglyceride absorption w... | 1,121,660 | D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D002908:Chronic Disease; D004063:Digestion; D006801:Humans; D006868:Hydrolysis; D008722:Methods; D008875:Middle Aged; D010169:Palmitic Acids; D010195:Pancreatitis; D014280:Triglycerides; D014316:Tritium | Schweizerische medizinische Wochenschrift | 1,975 | D002250:Carbon Radioisotopes; D010169:Palmitic Acids; D014280:Triglycerides; D014316:Tritium | |
Treatment of poor-prognosis early rheumatoid arthritis. A randomized study of treatment with methotrexate, cyclosporin A, and intraarticular corticosteroids compared with sulfasalazine alone. | OBJECTIVE
To determine whether a regimen of methotrexate, cyclosporin A, and corticosteroids introduced at onset in poor-prognosis rheumatoid arthritis (RA) can produce a significant improvement in outcome compared with standard monotherapy with sulfasalazine (SSZ).
METHODS
Eighty-two consecutive patients presenting ... | 10.1002/1529-0131(200008)43:8<1809::AID-ANR17>3.0.CO;2-D | 10,943,871 | D000305:Adrenal Cortex Hormones; D018501:Antirheumatic Agents; D001172:Arthritis, Rheumatoid; D001175:Arthrography; D016572:Cyclosporine; D004359:Drug Therapy, Combination; D006801:Humans; D007270:Injections, Intra-Articular; D008727:Methotrexate; D010352:Patient Dropouts; D011379:Prognosis; D012044:Regression Analysis... | Arthritis and rheumatism | 2,000 | D000305:Adrenal Cortex Hormones; D018501:Antirheumatic Agents; D012460:Sulfasalazine; D016572:Cyclosporine; D008727:Methotrexate |
Solving nursing shortages: a common priority. | AIMS AND OBJECTIVES
This paper provides a context for this special edition. It highlights the scale of the challenge of nursing shortages, but also makes the point that there is a policy agenda that provides workable solutions.
RESULTS
An overview of nurse:population ratios in different countries and regions of the w... | 10.1111/j.1365-2702.2008.02636.x | 19,146,584 | D014943:Global Health; D006292:Health Priorities; D009726:Nurses; D010934:Planning Techniques; D011050:Policy Making | Journal of clinical nursing | 2,008 | |
Computational simulation of oxygen diffusion in aortic valve leaflet for tissue engineering applications. | BACKGROUND AND AIM OF THE STUDY
Tissue thickness plays an important role in oxygen and nutrient transport and supply of tissue-engineered aortic valves. The study aim was to investigate the effect of tissue thickness and thickness variation on oxygen diffusion in a three-dimensional (3D) aortic valve leaflet model.
M... | 19,137,804 | D000818:Animals; D001021:Aortic Valve; D003198:Computer Simulation; D021621:Imaging, Three-Dimensional; D023421:Models, Animal; D008954:Models, Biological; D010100:Oxygen; D010101:Oxygen Consumption; D013552:Swine; D023822:Tissue Engineering | The Journal of heart valve disease | 2,008 | D010100:Oxygen | |
Streptomyces abietis sp. nov., a cellulolytic bacterium isolated from soil of a pine forest. | Cellulolytic bacteria A191(T), A192 and A193 isolated from the soil of Sakhalin fir forest in Hokkaido, Japan were studied phenotypically, genotypically and phylogenetically. Analysis of their 16S rRNA gene and gyrB sequences and DNA base composition suggested that these isolates were conspecific and members of the gen... | 10.1099/ijs.0.053025-0 | 23,990,653 | D028202:Abies; D015373:Bacterial Typing Techniques; D001482:Base Composition; D027081:DNA Gyrase; D004269:DNA, Bacterial; D005227:Fatty Acids; D007564:Japan; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S; D017422:Sequence Analysis, DNA; D012988:Soil ... | International journal of systematic and evolutionary microbiology | 2,013 | D004269:DNA, Bacterial; D005227:Fatty Acids; D012336:RNA, Ribosomal, 16S; D027081:DNA Gyrase |
Natural inactivation of phosphorus by aluminum in atmospherically acidified water bodies. | Atmospheric acidification of catchment-lake ecosystems may provide natural conditions for the in-lake control of P cycling. This process is based on the elevated transport of aluminum from acidified soils and its subsequent precipitation in the water body and is described for strongly acidified forest lakes, acidified ... | 10.1016/s0043-1354(01)00112-9 | 12,230,160 | D015258:Acid Rain; D000535:Aluminum; D017753:Ecosystem; D019015:Geologic Sediments; D006863:Hydrogen-Ion Concentration; D010758:Phosphorus; D014197:Trees | Water research | 2,001 | D015258:Acid Rain; D010758:Phosphorus; D000535:Aluminum |
Prevalence, awareness, treatment and control of diabetes among elderly persons in an urban slum of delhi. | BACKGROUND
The increasing proportion of elderly persons is contributing to an increase in the prevalence of diabetes. The residents of urban slums are more vulnerable due to poverty and lack of access to health care.
OBJECTIVE
To estimate the prevalence of diabetes in elderly persons in an urban slum and to assess th... | 10.4103/0970-0218.103472 | 23,293,438 | Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine | 2,012 | ||
Determination of derivatized amino acids in human embryo culture media by gas chromatography. | An adequate analytical method for determination of amino acids can provide a better insight in the metabolism of in vitro human embryo cultures, increasing the success rate of embryo implantation. Since individual amino acid amounts per embryo occur in the nanogram range, GC was the technique of choice, due to its inhe... | 10.1016/j.jchromb.2007.08.006 | 17,765,668 | D000596:Amino Acids; D002849:Chromatography, Gas; D003470:Culture Media; D046149:Embryo Culture Techniques; D006801:Humans; D015203:Reproducibility of Results | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences | 2,007 | D000596:Amino Acids; D003470:Culture Media |
Induced pluripotent stem cells: epigenetic memories and practical implications. | Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors. It was generally assumed that iPSCs are functionally equivalent to their embryonic stem cell (ESC) counterparts. Recently, a number... | 10.1093/molehr/gaq091 | 21,059,705 | D000465:Algorithms; D000818:Animals; D053595:Embryonic Stem Cells; D044127:Epigenesis, Genetic; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D051379:Mice | Molecular human reproduction | 2,010 | |
A taxonomic checklist of the mosquitoes of Iowa. | The last published report of the mosquito species composition present in the state of Iowa was published in 1969 and included 43 species in 8 genera. Since that time, reassessment of specimens in the Iowa State Insect Collection and annual mosquito surveillance efforts have yielded 12 new species records, bringing the ... | 10.2987/13-6388.1 | 25,102,595 | D000818:Animals; D058448:Biota; D009033:Culicidae; D007484:Iowa; D011156:Population Density | Journal of the American Mosquito Control Association | 2,014 | |
Depressed adolescents of depressed and nondepressed mothers: tests of an interpersonal impairment hypothesis. | Two groups of depressed youngsters were compared. From an interpersonal perspective, it was hypothesized that depressed adolescents of depressed mothers would have significantly more interpersonal dysfunction than depressed youngsters of nondepressed mothers. In a large community sample of youth and their families, 65 ... | 10.1037//0022-006x.69.2.284 | 11,393,605 | D000293:Adolescent; D016241:Child of Impaired Parents; D003865:Depressive Disorder, Major; D019263:Dysthymic Disorder; D005260:Female; D006801:Humans; D008297:Male; D009034:Mother-Child Relations; D009035:Mothers; D010553:Personality Development; D012307:Risk Factors; D012951:Socialization | Journal of consulting and clinical psychology | 2,001 | |
Apertureless near-field Raman spectroscopy. | We report on the tip-enhanced Raman spectra of C60 obtained on a custom-built apertureless scanning near-field optical microscope. A commercial atomic force microscope tip coated with 100 nm thickness of gold was used to enhance locally the Raman signal and permit topographic and spectral information to be acquired sim... | 10.1046/j.1365-2818.2003.01166.x | 12,787,109 | Journal of microscopy | 2,003 | ||
GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. | Parkinson's disease (PD) is characterized by the progressive loss of the substantia nigra (SN) dopaminergic neurons projecting to the striatum. Neurotrophic factors may have the potential to prevent or slow down the degenerative process occurring in PD. To that end, we examined whether low amounts of glial cell line-de... | 8,987,758 | D000818:Animals; D000831:Animals, Newborn; D002214:Capsules; D003342:Corpus Striatum; D006224:Cricetinae; D003714:Denervation; D004298:Dopamine; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor; D007150:Immunohistochemistry; D007668:Kidney; D008474:Medial Forebrain Bundle; D009414:Nerve Growth Factor... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 1,997 | D002214:Capsules; C495041:Gdnf protein, rat; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine | |
Selling a not-for-profit hospital. | Today, hospitals, nursing homes, surgery centers, health centers, clinics, and medical practices are being bought and sold like any other business. However, unique issues may arise in the sale of not-for-profit hospitals that may not be present in the sale of other businesses. | 10,280,600 | D004469:Economics, Hospital; D006075:Governing Board; D006268:Health Facilities; D006273:Health Facility Merger; D006788:Hospitals, Voluntary; D014481:United States | Trustee : the journal for hospital governing boards | 1,987 | ||
Local experience-dependent changes in the wake EEG after prolonged wakefulness. | STUDY OBJECTIVES
Prolonged wakefulness leads to a progressive increase in sleep pressure, reflected in a global increase in slow wave activity (SWA, 0.5-4.5 Hz) in the sleep electroencephalogram (EEG). A global increase in wake theta activity (5-9 Hz) also occurs. Recently, it was shown that prolonged wakefulness in ro... | 10.5665/sleep.2302 | 23,288,972 | D000328:Adult; D001921:Brain; D001931:Brain Mapping; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D009473:Neuronal Plasticity; D012892:Sleep Deprivation; D013647:Task Performance and Analysis; D014851:Wakefulness; D055815:Young Adult | Sleep | 2,013 | |
Layer-specific intracortical connectivity revealed with diffusion MRI. | In this work, we show for the first time that the tangential diffusion component is orientationally coherent at the human cortical surface. Using diffusion magnetic resonance imaging (dMRI), we have succeeded in tracking intracortical fiber pathways running tangentially within the cortex. In contrast with histological ... | 10.1093/cercor/bhs311 | 23,099,298 | D000368:Aged; D002540:Cerebral Cortex; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways | Cerebral cortex (New York, N.Y. : 1991) | 2,014 | |
Early diagnosis of dementia in primary care: a representative eight-year follow-up study in Lower Saxony, Germany. | OBJECTIVE
To investigate whether primary care competency in early diagnosis of dementia might have changed during 1993 and 2001.
METHOD
By means of a representative follow-up survey 122 out of 170 (71.8%) family physicians (FPs) in Lower Saxony, Germany, were randomly assigned to two written case samples presenting a... | 10.1002/gps.1646 | 16,955,450 | D000328:Adult; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease; D002983:Clinical Competence; D003704:Dementia; D015140:Dementia, Vascular; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D011320:Primary Health C... | International journal of geriatric psychiatry | 2,007 | |
Congenital infiltrating lipomatosis of the face with temporomandibular joint ankylosis. | Congenital infiltrating lipomatosis of the face (CIL-F) is characterized by unilateral diffuse infiltration of facial soft tissue by mature adipose cells with associated skeletal hypertrophy. The disease is also considered a subtype of partial hemifacial hyperplasia. We present a case of right hemifacial swelling with ... | 10.4103/njms.NJMS_59_17 | 33,041,589 | National journal of maxillofacial surgery | 2,020 | ||
Post-mortem test for low-boiling arson residues of gasoline by gas chromatography-ion-trap mass spectrometry. | Using headspace capillary GC-MS with ion-trap detection, the additive in motor gasoline, MTBE (methyl tert.-butyl ether), was spotted in the blood from five victims of arsons set off with motor gasoline. In the brain from a death of a fire started by ignited isoparaffins, a number of branched C8 alkanes were found. Sin... | 10.1016/0378-4347(94)00394-7 | 7,894,683 | D004987:Ethers; D005391:Firesetting Behavior; D008401:Gas Chromatography-Mass Spectrometry; D005742:Gasoline; D006801:Humans; D008738:Methyl Ethers; D011180:Postmortem Changes; D012997:Solvents; D013548:Sweden | Journal of chromatography. B, Biomedical applications | 1,994 | D004987:Ethers; D005742:Gasoline; D008738:Methyl Ethers; D012997:Solvents; C043243:methyl tert-butyl ether |
Neonatal infections. | Neonatal infection still carries a high mortality and morbidity. The spectrum of infection is broad and includes congenital syphilis and viral infections. Sadly, nosocomial infection is common, particularly due to coagulase negative staphylococci. Very low birth weight infants are at high risk, particularly following p... | 10.1097/00008480-199602000-00003 | 8,680,517 | D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D007239:Infections; D009503:Neutropenia; D012307:Risk Factors; D015996:Survival Rate | Current opinion in pediatrics | 1,996 | D016178:Granulocyte-Macrophage Colony-Stimulating Factor |
Bovine coagulation factor V visualized with electron microscopy. Ultrastructure of the isolated activated forms and of the activation fragments. | Single chain bovine factor V (Mr = 330,000) was isolated and visualized by means of high resolution transmission electron microscopy of negatively stained samples. Both factor Va, activated by thrombin or by the factor V activator from Russell's viper venom, and the isolated fragments, D (Mr = 105,000), C1 (Mr = 150,00... | 3,087,994 | D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005165:Factor V; D015943:Factor Va; D005976:Glutaral; D008854:Microscopy, Electron; D010446:Peptide Fragments; D013917:Thrombin | The Journal of biological chemistry | 1,986 | D010446:Peptide Fragments; D015943:Factor Va; D005165:Factor V; D013917:Thrombin; D005976:Glutaral | |
Scorpion toxins for the reversal of BoNT-induced paralysis. | The botulinum neurotoxins, characterized by their neuromuscular paralytic effects, are the most toxic proteins known to man. Due to their extreme potency, ease of production, and duration of activity, the BoNT proteins have been classified by the Centers for Disease Control as high threat agents for bioterrorism. In an... | 24,252,544 | D000595:Amino Acid Sequence; D000818:Animals; D001905:Botulinum Toxins; D018999:Charybdotoxin; D051379:Mice; D008969:Molecular Sequence Data; D009119:Muscle Contraction; D010243:Paralysis; D010455:Peptides; D010791:Phrenic Nerve; D026902:Potassium Channel Blockers; D012117:Resins, Synthetic; D012604:Scorpion Venoms | Bioorganic & medicinal chemistry letters | 2,013 | D010455:Peptides; D026902:Potassium Channel Blockers; D012117:Resins, Synthetic; D012604:Scorpion Venoms; D018999:Charybdotoxin; C077910:margatoxin; C064719:iberiotoxin; D001905:Botulinum Toxins | |
[Sleep apnea syndrome and stroke in the elderly population]. | The objective was to compare the prevalence of sleep apnea syndrome (SAS) in elderly individuals with a history of stroke to the one in individuals, matched by age and sex with a history of insomnia. To determine if previous subjective sleep complaints in the elderly are associated with stroke. A cross-sectional study ... | 10,637,925 | D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002391:Catchment Area, Health; D006970:Disorders of Excessive Somnolence; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D017286:Polysomnography; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Se... | Revue neurologique | 1,999 | ||
Source monitoring in eyewitness memory: implicit associations, suggestions, and episodic traces. | Both the distinctiveness heuristic and discrepancy detection hypotheses were investigated by independently manipulating both schema consistency and incidental suggestion in an eyewitness memory paradigm. A sequence of slides was shown, followed by a postevent questionnaire that contained both schema-typical and schema-... | 10.3758/bf03193072 | 16,383,165 | D001244:Association; D006801:Humans; D008568:Memory; D013404:Suggestion; D011795:Surveys and Questionnaires | Memory & cognition | 2,005 | |
Tyrosine 687 phosphorylated Alzheimer's amyloid precursor protein is retained intracellularly and exhibits a decreased turnover rate. | Tyrosine 687 (Y687) of the Alzheimer's amyloid precursor protein (APP) was shown to be phosphorylated in the brains of Alzheimer's disease patients. This residue lies within a typical endocytosis consensus motif commonly found in molecules with receptor functions, strongly suggesting a potential role for APP in signal ... | 10.1159/000101831 | 17,596,701 | D016564:Amyloid beta-Protein Precursor; D000818:Animals; D019556:COS Cells; D037281:Calnexin; D002522:Chlorocebus aethiops; D003513:Cycloheximide; D015870:Gene Expression; D049452:Green Fluorescent Proteins; D006801:Humans; D010766:Phosphorylation; D011500:Protein Synthesis Inhibitors; D050765:Qa-SNARE Proteins; D01334... | Neuro-degenerative diseases | 2,007 | D016564:Amyloid beta-Protein Precursor; D011500:Protein Synthesis Inhibitors; D050765:Qa-SNARE Proteins; D037281:Calnexin; D049452:Green Fluorescent Proteins; D014443:Tyrosine; D003513:Cycloheximide |
New variant of chromosome 11. | An additional C-positive band in the centromeric region (p11) was observed in a man. By GTG- and RBA-techniques it was positively stained but by QFQ-technique the staining intensity was negative. Although he was identified through fetal loss in his wife, it apparently represents a familial variant whose clinical signif... | 10.1002/ajmg.1320500314 | 8,042,675 | D000026:Abortion, Habitual; D002503:Centromere; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D014998:Y Chromosome | American journal of medical genetics | 1,994 | |
Using Improved Serial Blood Sampling Method of Mice to Study Pharmacokinetics and Drug-Drug Interaction. | In pharmacokinetic evaluation of mice, using serial sampling methods rather than a terminal blood sampling method could reduce the number of animals needed and lead to more reliable data by excluding individual differences. In addition, using serial sampling methods can be valuable for evaluation of the drug-drug inter... | 10.1002/jps.24236 | 28,756,848 | Journal of pharmaceutical sciences | 2,015 | ||
Mechanical properties of reversibly cross-linked ultrathin polyelectrolyte complexes. | Tensile properties of microcoupons of polyelectrolyte complex, formed by the multilayering method, were determined using a micromechanical analysis system. The degree of internal ion-pair ("electrostatic") cross-linking was reversibly controlled by exposure to salt solution of varying concentration, which "doped" count... | 10.1021/ja055892n | 16,506,773 | Journal of the American Chemical Society | 2,006 | ||
The relative role of PAF-acether and icosanoids in septic shock. | Endotoxemia and gram negative sepsis remain a clinically important problem since mortality rate is still high in these diseases. Recently, the participation of some new potential mediators in this pathology is beginning to be demonstrated but the results obtained on animal models with specific inhibitors are contradict... | 10.1016/0031-6989(86)90040-8 | 3,774,851 | D000818:Animals; D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D004537:Eicosanoic Acids; D046934:Ginkgolides; D007783:Lactones; D008297:Male; D010936:Plant Extracts; D010972:Platelet Activating Factor; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic | Pharmacological research communications | 1,986 | D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D004537:Eicosanoic Acids; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; C045856:ginkgolide B |
Nodular fasciitis presenting as a rapidly enlarging episcleral mass in a 3-year-old. | A rapidly enlarging periocular mass in a child obligates the treating physician to rule out a malignancy, especially a rhabdomyosarcoma. A 3-year-old girl presented with a 5-day history of a rapidly growing episcleral mass superonasal to the globe, adjacent to the superior rectus muscle insertion. The lesion was locall... | 10.3928/0191-3913-19900501-13 | 2,366,127 | D002675:Child, Preschool; D003937:Diagnosis, Differential; D005134:Eye Neoplasms; D005143:Eyelids; D005208:Fasciitis; D005260:Female; D005347:Fibroblasts; D006801:Humans; D012509:Sarcoma; D012590:Sclera; D015422:Scleral Diseases | Journal of pediatric ophthalmology and strabismus | 1,990 | |
Protein and energy relations in the broiler chicken. 8. Comparison involving protein- and lysine-adequate and inadequate diets on lipid metabolism. | Chickens were fed on diets containing either 12.8 MJ, 150 g crude protein (nitrogen x 6.25)/kg or 12.8 MJ, 200 g crude protein/kg to determine differences in metabolism. The diet containing 12.8 MJ, 150 g crude protein/kg contained either 8 or 12 g lysine/kg. Treatment variables examined in vitro were lipogenesis, gluc... | 10.1079/bjn19900051 | 2,121,269 | D000818:Animals; D001219:Aspartate Aminotransferases; D001835:Body Weight; D002645:Chickens; D004044:Dietary Proteins; D002149:Energy Intake; D005943:Gluconeogenesis; D007521:Isocitrate Dehydrogenase; D050356:Lipid Metabolism; D008099:Liver; D008239:Lysine; D008291:Malate Dehydrogenase; D011773:Pyruvates | The British journal of nutrition | 1,990 | D004044:Dietary Proteins; D011773:Pyruvates; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D001219:Aspartate Aminotransferases; D008239:Lysine |
[Comparative effectiveness of treatment of non-Hodgkin's lymphoma in children using protocols BFM NHL-90 and non-programmed courses based on the ACOP regimen]. | 170 NHL children aged 1-14 [mean age 6] have been treated for the last 5 years. The diagnostic examination included the disease history, physical examination, bone marrow cytology, tumor histology (all patients), immunophenotyping (17 cases), x-ray and sonography of the chest and abdomen. According to the International... | 8,026,684 | D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols; D001215:Asparaginase; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide; D003630:Daunorubicin; D004317:Doxorubicin; D006801:Humans; D007223:Infant; D008228:Lymphoma, Non-Hodgkin; D011239:Prednisolone; D011241:Prednisone; D014750... | Gematologiia i transfuziologiia | 1,994 | D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D001215:Asparaginase; D011241:Prednisone; D003630:Daunorubicin | |
Age-related changes in muscle. | Sarcopenia is a debilitating condition that occurs with senescence. The present study places this entity in the context of life expectancy, then discusses the mechanism of muscle loss. The findings show deficits in muscle protein synthesis with advancing age and suggest that these deficits are specific to certain muscl... | 10,959,210 | D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D003687:Dehydroepiandrosterone; D004734:Energy Metabolism; D015444:Exercise; D020249:Hormone Replacement Therapy; D006801:Humans; D008017:Life Expectancy; D008875:Middle Aged; D008931:Mitochondria, Muscle; D009133:Muscular Atrophy; D009218:Myosins; D012518:Sarcome... | Mayo Clinic proceedings | 2,000 | D013739:Testosterone; D003687:Dehydroepiandrosterone; D009218:Myosins | |
Recent Trends in Detection of Huntingtin and Preclinical Models of Huntington's Disease. | Huntington's disease is a genetically inherited neurodegenerative disease that is characterized by neuronal cell death in the brain. Molecular biology techniques to detect and quantify huntingtin protein in biological samples involve fluorescence imaging, western blotting, and PCR. Modified cell lines are widely used a... | 10.1155/2014/190976 | 27,335,679 | ISRN molecular biology | 2,014 | ||
Blood Flow Volume Measurement in Cervical and Intracranial Arteries using Quantitative Magnetic Resonance Angiography and Duplex Sonography (Bocaccia) - A Prospective Observational Study. | PURPOSE
Cerebral blood flow volume is an important factor for the accurate diagnosis of neurovascular diseases and treatment indication. This study aims to assess correlations of blood flow volume measurements in cervical and intracranial arteries between duplex sonography and quantitative magnetic resonance angiograph... | 10.1055/a-1113-7343 | 32,340,045 | D001158:Arteries; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014463:Ultrasonography | Ultraschall in der Medizin (Stuttgart, Germany : 1980) | 2,021 | |
Morbidity before and after HAART initiation in Sub-Saharan African HIV-infected adults: a recurrent event analysis. | The incidence and determinants of severe morbidity recurrence in sub-Saharan African HIV-infected adults on antiretroviral therapy (ART) have never been reported. In a prospective cohort study of HIV-infected adults in Abidjan the association of severe morbidity occurrence and recurrence with follow-up CD4 counts and A... | 10.1089/aid.2006.0308 | 18,184,075 | D000328:Adult; D017954:Africa South of the Sahara; D019380:Anti-HIV Agents; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections; D006801:Humans; D008297:Male; D009017:Morbidity; D011446:Prospective Studies | AIDS research and human retroviruses | 2,007 | D019380:Anti-HIV Agents |
[Psoriatic arthritis : Overview of drug therapy options and administration characteristics]. | Psoriatic arthritis is a chronic inflammatory disease of the musculoskeletal system with association to skin psoriasis and is characterized by variable clinical symptoms with very heterogeneous degrees of disease suffering for patients. Clinical manifestations essentially include alterations to the skin and nails, peri... | 10.1007/s00393-016-0110-6 | 27,259,913 | D000893:Anti-Inflammatory Agents; D015535:Arthritis, Psoriatic; D003879:Dermatologic Agents; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D019317:Evidence-Based Medicine; D006801:Humans; D016896:Treatment Outcome | Zeitschrift fur Rheumatologie | 2,016 | D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents |
Determinants of oxygen desaturation in the course of ventilation during sleep in chronic obstructive pulmonary disease. | During sleep, none of 9 subjects with chronic obstructive pulmonary disease (COPD) were apneic. Despite ventilation, acute arterial oxygen desaturation of 11% or more occurred in 6 of them. The other 3 were nondesaturators (i.e., 3% or less desaturation) during sleep. The desaturation that occurred in the 6 subjects wi... | 10.1164/arrd.1980.122.6.849 | 7,458,058 | D002908:Chronic Disease; D006801:Humans; D008173:Lung Diseases, Obstructive; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D012119:Respiration; D012890:Sleep; D012891:Sleep Apnea Syndromes | The American review of respiratory disease | 1,980 | D010100:Oxygen |
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