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Camouflaged Hybrid Cancer Cell-Platelet Fusion Membrane Nanovesicles Deliver Therapeutic MicroRNAs to Presensitize Triple-Negative Breast Cancer to Doxorubicin. | Camouflaged cell-membrane-based nanoparticles have been gaining increasing attention owing to their improved biocompatibility and immunomodulatory properties. Using nanoparticles prepared from the membranes of specific cell types, or fusions derived from different cells membranes, can improve their functional performan... | 10.1002/adfm.202103600 | 34,899,115 | Advanced functional materials | 2,021 | ||
Therapeutic effects of in-vivo radiodynamic therapy (RDT) for lung cancer treatment: a combination of 15MV photons and 5-aminolevulinic acid (5-ALA). | Objective.Radiodynamic therapy (RDT) uses high-energy photon beams instead of visible/near-infrared light to treat deep-seated tumors that photodynamic therapy cannot achieve due to the low penetration depth of laser beams. The purpose of this study is to investigate the therapeutic effect of RDT with 15 MV photon beam... | 10.1088/2057-1976/ac9b5c | 36,263,662 | D000818:Animals; D051379:Mice; D000622:Aminolevulinic Acid; D000072078:Positron Emission Tomography Computed Tomography; D019788:Fluorodeoxyglucose F18; D008810:Mice, Inbred C57BL; D008175:Lung Neoplasms | Biomedical physics & engineering express | 2,022 | D000622:Aminolevulinic Acid; D019788:Fluorodeoxyglucose F18 |
Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats. | Purpose
This study was carried out to study the effect of anethole rich fraction on the Diabetic Nephropathy (DN) rats, and explore the mechanisms.
Methods
Male wistar rats were grouped into 4 (n = 6 per group): Control, junk food fed DN induced rats, low dose and high dose groups. DN was induced by oral junk food fe... | 10.1007/s40200-022-01101-4 | 36,404,830 | Journal of diabetes and metabolic disorders | 2,022 | ||
Motivational Interviewing in Primary-Care: Substance Use Disorders beyond AUDIT/DAST. | Primary-care settings have a unique advantage to reaching a broad range of the population and the ability to address a wide array of presenting problems, including substance-use. With high rates of substance-use in the United States and low rates of substance-use treatment utilization, the primary-care office is key in... | 10.1016/j.pop.2022.10.009 | 36,822,719 | D006801:Humans; D014481:United States; D062405:Motivational Interviewing; D019966:Substance-Related Disorders; D015438:Health Behavior; D003142:Communication; D009042:Motivation | Primary care | 2,023 | C040394:diethylaminosulfur trifluoride |
Separation of DNA restriction fragments by ion-exchange chromatography on FPLC columns Mono P and Mono Q. | Separation of DNA restriction fragments by FPLC ion-exchange chromatography on Mono Q and Mono P columns was investigated. The columns were found to be particularly suitable for the separation of fragments up to 500-600 bp long. Larger fragments can also be separated although less effectively. We found the following pr... | 10.1016/0003-2697(87)90558-6 | 2,890,317 | D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D004247:DNA; D004262:DNA Restriction Enzymes; D006863:Hydrogen-Ion Concentration; D007201:Indicator Dilution Techniques; D010316:Particle Size; D012150:Polymorphism, Restriction Fragment Length | Analytical biochemistry | 1,987 | D004247:DNA; D004262:DNA Restriction Enzymes |
On-line hemodialysis and hemoperfusion in a girl intoxicated by theophylline. | In a suicidal attempt, a 15-year-old girl had ingested about 40 g of theophylline from sustained-release preparations. Symptoms of intoxication increased and serum concentrations of theophylline rose from 438 to 1,000 mumol/l. Conservative therapy was also combined by the use of hemodialysis as well as charcoal hemoper... | 10.1111/j.0954-6820.1988.tb17697.x | 3,389,209 | D000293:Adolescent; D003692:Delayed-Action Preparations; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D006435:Renal Dialysis; D013806:Theophylline | Acta medica Scandinavica | 1,988 | D003692:Delayed-Action Preparations; D013806:Theophylline |
Recombinant tissue plasminogen activator promotes, and progesterone attenuates, microglia/macrophage M1 polarization and recruitment of microglia after MCAO stroke in rats. | BACKGROUND
Tissue plasminogen activator (tPA) is one of the few approved treatments for stroke, but its effects on the phenotype of microglia/macrophages are poorly understood. One of its side effects is an increase in the inflammatory response leading to neuronal cell damage and death in the ischemic cascade after str... | 26,093,305 | D000818:Animals; D000893:Anti-Inflammatory Agents; D016764:Cell Polarity; D054405:Chemokine CCL3; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery; D008264:Macrophages; D008297:Male; D019278:Matrix Metalloproteinase 3; D017628:Microglia; D011374:Progesterone; D051381:Rats; D017207:Rats, Spragu... | Brain, behavior, and immunity | 2,015 | D000893:Anti-Inflammatory Agents; D054405:Chemokine CCL3; D011994:Recombinant Proteins; D011374:Progesterone; D010959:Tissue Plasminogen Activator; D019278:Matrix Metalloproteinase 3 | |
Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. | The pericellular matrix (PCM) is a narrow region of tissue that completely surrounds chondrocytes in articular cartilage. Previous theoretical models of the "chondron" (the PCM with enclosed cells) suggest that the structure and properties of the PCM may significantly influence the mechanical environment of the chondro... | 10.1016/j.jbiomech.2007.01.009 | 17,397,851 | D000818:Animals; D002358:Cartilage, Articular; D019902:Chondrocytes; D024141:Collagen Type IV; D019245:Compressive Strength; D005109:Extracellular Matrix; D005260:Female; D021621:Imaging, Three-Dimensional; D008954:Models, Biological; D013552:Swine; D016474:Weight-Bearing | Journal of biomechanics | 2,007 | D024141:Collagen Type IV |
A systematic forest survey showing an association of Saccharomyces paradoxus with oak leaf litter. | Although we understand the genetics of the laboratory model yeast Saccharomyces cerevisiae very well, we know little about the natural ecology and environment that shaped its genome. Most isolates of Saccharomyces paradoxus, the wild relative of S. cerevisiae, come from oak trees, but it is not known whether this is be... | 10.1111/1758-2229.12446 | 27,481,438 | Environmental microbiology reports | 2,016 | ||
A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants. | [reaction: see text]. Known lanosterol synthase mutants produce monocyclic or tetracyclic byproducts from oxidosqualene. We describe Erg7 Tyr510 mutants that cause partial substrate misfolding and generate a tricyclic byproduct. This novel triterpene, (13alphaH)-isomalabarica-14(27),17E,21-trien-3beta-ol, is the likely... | 10.1021/ol052725j | 16,435,854 | D000818:Animals; D005075:Biological Evolution; D000075202:Contraindications; D019751:Intramolecular Transferases; D015394:Molecular Structure; D009154:Mutation; D011161:Porifera; D013185:Squalene; D014315:Triterpenes | Organic letters | 2,006 | C514122:(13alphaH)-isomalabarica-14(27),17E,21-trien-3beta-ol; C002821:2,3-oxidosqualene; D014315:Triterpenes; D013185:Squalene; D019751:Intramolecular Transferases; C021924:lanosterol synthase |
Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by Inhibition of Inflammatory Response and ERK Signaling Pathways. | Background and Objectives. Curcumin has long been used to treat age-related diseases, such as atherosclerosis and coronary heart disease. In this study, we explored the effects of curcumin on the development of abdominal aortic aneurysm (AAA). Methods. ApoE(-/-) mice were randomly divided into 3 groups: AngII group, An... | 10.1155/2014/270930 | 25,431,606 | Evidence-based complementary and alternative medicine : eCAM | 2,014 | ||
Clinical Presentation and Management of Methicillin-Resistant Staphylococcus aureus Pericarditis-Systematic Review. | In the expanding era of antibiotic resistance, new strains of Staphylococcus aureus have emerged which possess resistance to traditionally used antibiotics (MRSA). Our review aimed to systematically synthesize information on previously described MRSA pericarditis cases. The only criterion for inclusion was the isolatio... | 10.3390/jcdd9040103 | 35,448,079 | Journal of cardiovascular development and disease | 2,022 | ||
Predicting nodal metastases in squamous cell carcinoma of the oral tongue using artificial intelligence. | OBJECTIVE
The presence of occult nodal metastases in patients with squamous cell carcinoma (SCC) of the oral tongue has implications for treatment. Upwards of 30% of patients will have occult nodal metastases, yet a significant number of patients undergo unnecessary neck dissection to confirm nodal status. This study s... | 10.1016/j.amjoto.2023.104102 | 37,948,827 | American journal of otolaryngology | 2,024 | ||
Connectivity reveals relationship of brain areas for reward-guided learning and decision making in human and monkey frontal cortex. | Reward-guided decision-making depends on a network of brain regions. Among these are the orbitofrontal and the anterior cingulate cortex. However, it is difficult to ascertain if these areas constitute anatomical and functional unities, and how these areas correspond between monkeys and humans. To address these questio... | 10.1073/pnas.1410767112 | 25,947,150 | D000818:Animals; D063132:Connectome; D003657:Decision Making; D005625:Frontal Lobe; D006801:Humans; D007858:Learning; D008251:Macaca; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D012201:Reward; D013045:Species Specificity | Proceedings of the National Academy of Sciences of the United States of America | 2,015 | |
Examining the Use of a Polypill in Cardiovascular Disease Prevention. | Cardiovascular disease (CVD) is a significant cause of death worldwide. To address the global burden of CVD and its risk factors, the polypill, an all-in-one therapy that combines multiple existing medications for preventing CVD and reducing CVD events (such as angiotensin-converting enzyme inhibitor, beta-blocker, sta... | 10.1097/CRD.0000000000000574 | 37,401,822 | Cardiology in review | 2,023 | ||
Drug-resistant primary headache patients undergoing surgical therapies: how should we assess outcomes? | The introduction of neurostimulation procedures for chronic drug-resistant primary headaches has offered new hope to patients, but has also introduced new problems. The methods to be used in assessing clinical outcomes and monitoring treatment efficacy need careful attention. The International Headache Society guidelin... | 10.1007/s10072-010-0295-4 | 20,464,593 | D004599:Electric Stimulation Therapy; D051270:Headache Disorders, Primary; D006801:Humans; D017063:Outcome Assessment, Health Care; D010147:Pain Measurement; D017060:Patient Satisfaction | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2,010 | |
[Modern methods for surveillance of communicable disease: general introduction (author's transl)]. | Epidemiological surveillance has now become a fully developed discipline, to which several technical specialties contribute. All kinds of new problems resulting from present conditions of life have enlarged the field of surveillance beyond the old concept of morbidity-mortality. This has necessitated the application of... | 218,259 | D002487:Centers for Disease Control and Prevention, U.S.; D003140:Communicable Disease Control; D003141:Communicable Diseases; D004812:Epidemiologic Methods; D006801:Humans; D007255:Information Services; D007391:International Cooperation; D014481:United States; D014944:World Health Organization | Revue d'epidemiologie et de sante publique | 1,978 | ||
Frontal Assessment Battery and brain perfusion images in amnestic mild cognitive impairment. | AIM
Some patients with mild cognitive impairment (MCI) may have impaired frontal lobe function. To assess the frontal lobe functions of subjects with MCI using the Frontal Assessment Battery (FAB) and to identify the brain regions responsible for FAB performance.
METHODS
Based on the FAB score cut-off of 12/13, 38 MC... | 10.1111/j.1447-0594.2010.00645.x | 20,807,243 | D000368:Aged; D000647:Amnesia; D002560:Cerebrovascular Circulation; D003072:Cognition Disorders; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon | Geriatrics & gerontology international | 2,011 | |
Evaluation of routine telephone transmission of nuclear medicine studies. | Rapid and reliable transmission of nuclear medicine studies using conventional telephone lines and commercially available modems and computer systems has been accomplished through use of software developed within the authors' hospital. Original digital images of all-night and weekend studies, acquired on any of the acq... | 10.1097/00003072-198901000-00007 | 2,496,946 | D003195:Computer Communication Networks; D003199:Computer Systems; D003362:Cost-Benefit Analysis; D011877:Radionuclide Imaging; D012984:Software; D013689:Telephone | Clinical nuclear medicine | 1,989 | |
Sepsis and Septic Shock Strategies. | Three therapeutic principles most substantially improve organ dysfunction and survival in sepsis: early, appropriate antimicrobial therapy; restoration of adequate cellular perfusion; timely source control. The new definitions of sepsis and septic shock reflect the inadequate sensitivity, specify, and lack of prognosti... | 10.1016/j.suc.2017.07.003 | 29,132,513 | D000900:Anti-Bacterial Agents; D062186:Arterial Pressure; D009202:Cardiomyopathies; D002496:Central Venous Pressure; D003422:Critical Care; D003693:Delirium; D006454:Hemoglobins; D006801:Humans; D019344:Lactic Acid; D010100:Oxygen; D010347:Patient Care Planning; D011379:Prognosis; D012151:Resuscitation; D018805:Sepsis;... | The Surgical clinics of North America | 2,017 | D000900:Anti-Bacterial Agents; D006454:Hemoglobins; D014665:Vasodilator Agents; D019344:Lactic Acid; D010100:Oxygen |
Ecology and evolution of chlamydial symbionts of arthropods. | The phylum Chlamydiae consists of obligate intracellular bacteria including major human pathogens and diverse environmental representatives. Here we investigated the Rhabdochlamydiaceae, which is predicted to be the largest and most diverse chlamydial family, with the few described members known to infect arthropod hos... | 10.1038/s43705-022-00124-5 | 37,938,728 | ISME communications | 2,022 | ||
Clinicopathological evaluation of biological behavior of submucosal invasive gastric carcinomas: relationship among lymph node metastasis, mucin phenotype and proliferative activity. | BACKGROUND
Gastric carcinomas have been classified into the differentiated and undifferentiated type, on the basis of its tendency to gland formation. As a result of recent advances in mucin histochemistry, mucin phenotypes of gastric carcinomas have been investigated. However, no consensus on the evaluation of the gra... | 10.2152/jmi.54.99 | 17,380,020 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049109:Cell Proliferation; D005260:Female; D005753:Gastric Mucosa; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009077:Mucins; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D010641:Phenotype; D018809:Proliferat... | The journal of medical investigation : JMI | 2,007 | D009077:Mucins; D018809:Proliferating Cell Nuclear Antigen |
[Validity of epidemiological surveys with low participation rates]. | INTRODUCTION
The purpose of the present study was to compare the characteristics of epidemiological survey non-respondents with the characteristics of respondents who participated by mail and phone.
MATERIAL AND METHODS
The study was based on data from questionnaires and registered data on socio-demographics. The Chi... | 19,208,330 | D000328:Adult; D002648:Child; D002653:Child Behavior Disorders; D002675:Child, Preschool; D003256:Community Participation; D032984:Ethics, Research; D006801:Humans; D007223:Infant; D010290:Parents; D011795:Surveys and Questionnaires; D013689:Telephone | Ugeskrift for laeger | 2,009 | ||
Development of the Asian Transplant Registry Under the Asian Society of Transplantation. | INTRODUCTION
In the Asian region, no international organ transplantation registry exists. Individual centers maintain their own database, or some countries developed a national registration system. To promote collaboration among Asian transplantation societies, the Asian Society of Transplantation (AST) has developed a... | 10.1016/j.transproceed.2019.12.058 | 32,362,464 | D044466:Asian People; D066264:Datasets as Topic; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D002052:Myanmar; D010679:Philippines; D012042:Registries; D056910:Republic of Korea | Transplantation proceedings | 2,020 | |
Ultrasound-guided percutaneous and transhepatic cholecystostomy: a complementary procedure to therapeutic endoscopy. | Percutaneous cholecystostomy is an expanding technique since the use of ultrasonography permits a precise puncture of the gall bladder. Cholecystitis is a classical complication of endoscopic maneuvers in the biliary tract or can be associated with obstructive jaundice. Following their results the authors conclude on t... | 10.1055/s-2007-1018487 | 3,893,999 | D000367:Age Factors; D000368:Aged; D001660:Biliary Tract Diseases; D002758:Cholangiography; D002764:Cholecystitis; D004322:Drainage; D004724:Endoscopy; D005260:Female; D005704:Gallbladder; D006801:Humans; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography | Endoscopy | 1,985 | |
The effect of neuromuscular blockers in patients with intra-abdominal hypertension. | OBJECTIVE
The objective was to prospectively study the effect of neuromuscular blockers on intra-abdominal pressure (IAP) and a number of physiological variables in patients with increased IAP.
DESIGN
Prospective cohort study.
SETTING
Intensive care unit of the Ghent University Hospital.
PATIENTS AND PARTICIPANTS... | 10.1007/s00134-007-0758-0 | 17,594,072 | D000005:Abdomen; D000328:Adult; D000368:Aged; D001279:Atracurium; D016638:Critical Illness; D005260:Female; D006801:Humans; D006973:Hypertension; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents; D011446:Prospective Studies | Intensive care medicine | 2,007 | D009466:Neuromuscular Blocking Agents; D001279:Atracurium; C101584:cisatracurium |
[Correlations between haplogroup membership and Y-STR haplotype as a potential measure of quality control in forensic examinations]. | A correlation between particular Y-STR alleles from the so-called "minimal haplotype" and haplogroup membership of the Y chromosome was tested. We collected 146 Y chromosomes from haplogroups R1*, R1a1* and 1* and estimated the frequency of Y-STR alleles in each haplogroup. We then used different algorithms to assign a... | 17,131,759 | D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D020080:Tandem Repeat Sequences; D014158:Transcription, Genetic | Archiwum medycyny sadowej i kryminologii | 2,006 | ||
Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics. | Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, e.g., VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF-PDGFRs binding challenges this paradigm and calls for investigation of other ligand-receptor binding possibilities. We utilized surface plas... | 10.1038/s41598-017-16610-z | 29,180,757 | D042783:Endothelial Cells; D006801:Humans; D007700:Kinetics; D008024:Ligands; D008954:Models, Biological; D009369:Neoplasms; D010982:Platelet-Derived Growth Factor; D011485:Protein Binding; D017479:Receptors, Platelet-Derived Growth Factor; D040262:Receptors, Vascular Endothelial Growth Factor; D015203:Reproducibility ... | Scientific reports | 2,017 | D008024:Ligands; D010982:Platelet-Derived Growth Factor; D017479:Receptors, Platelet-Derived Growth Factor; D040262:Receptors, Vascular Endothelial Growth Factor |
Mouse mammary tumor virus molecular biology and oncogenesis. | Mouse mammary tumor virus (MMTV), which was discovered as a milk-transmitted, infectious cancer-inducing agent in the 1930s, has been used since that time as an animal model for the study of human breast cancer. Like other complex retroviruses, MMTV encodes a number of accessory proteins that both facilitate infection ... | 10.3390/v2092000 | 21,274,409 | D000818:Animals; D002472:Cell Transformation, Viral; D004847:Epithelial Cells; D008214:Lymphocytes; D008324:Mammary Tumor Virus, Mouse; D012192:Retroviridae Infections; D014412:Tumor Virus Infections; D014764:Viral Proteins; D037521:Virulence Factors | Viruses | 2,010 | D014764:Viral Proteins; D037521:Virulence Factors |
Dissipation of Antimicrobials in a Seasonally Frozen Soil after Beef Cattle Manure Application. | Land application of manure containing antimicrobials results in the dispersion of the antimicrobials in agro-ecosystems. Dissipation of excreted antimicrobials in seasonally frozen agricultural soils has not been fully characterized under field conditions. This study investigated the field dissipation kinetics of chlor... | 10.2134/jeq2016.01.0012 | 27,695,746 | D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002417:Cattle; D005615:Freezing; D008372:Manure; D000069466:Red Meat; D012987:Soil; D012989:Soil Pollutants; D015645:Tylosin | Journal of environmental quality | 2,016 | D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008372:Manure; D012987:Soil; D012989:Soil Pollutants; D015645:Tylosin |
The Histone Acetylation Modifications of Breast Cancer and their Therapeutic Implications. | The histone acetylation modifications (HAMs) influence a large number of cellular functions. They are mediated through histone acetyltransferase (HAT) and histone deacetylase (HDAC). Nowadays, people have realized that HAMs are crucial for development and prognosis of breast cancer. Investigations about abnormal HAMs i... | 10.1007/s12253-018-0433-5 | 29,948,617 | D000107:Acetylation; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms; D005260:Female; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D006801:Humans; D008297:Male | Pathology oncology research : POR | 2,018 | D014408:Biomarkers, Tumor; D056572:Histone Deacetylase Inhibitors; D006657:Histones |
Glutathione S-transferase omega suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila. | Loss-of-function mutation of the PTEN-induced kinase 1 (PINK1) gene is a common cause of early-onset Parkinson's disease (PD). Glutathione S-transferase omega (GSTO) is a phase II detoxification enzyme that conjugates targets to glutathione, and has recently been implicated in parkin-associated PD. In this study, we fo... | 23,867,819 | D000818:Animals; D030801:Animals, Genetically Modified; D059290:Dopaminergic Neurons; D029721:Drosophila Proteins; D004331:Drosophila melanogaster; D015971:Gene Expression Regulation, Enzymologic; D005982:Glutathione Transferase; D006706:Homeostasis; D008928:Mitochondria; D009474:Neurons; D010300:Parkinson Disease; D01... | Biochemical and biophysical research communications | 2,013 | D029721:Drosophila Proteins; D044767:Ubiquitin-Protein Ligases; D005982:Glutathione Transferase; C534484:PINK1 protein, Drosophila; D017346:Protein Serine-Threonine Kinases; C487430:park protein, Drosophila | |
Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. | AIMS
A new human coronavirus (HCoV), which has been designated SARS-CoV-2, began spreading in December 2019 in Wuhan City, China causing pneumonia called COVID-19. The spread of SARS-CoV-2 has been faster than any other coronaviruses that have succeeded in crossing the animal-human barrier. There is concern that this n... | 10.1016/j.lfs.2020.117592 | 32,222,463 | D000998:Antiviral Agents; D000073640:Betacoronavirus; D018352:Coronavirus Infections; D006801:Humans; D062105:Molecular Docking Simulation; D019384:Nucleic Acid Synthesis Inhibitors; D009705:Nucleosides; D012324:RNA-Dependent RNA Polymerase; D000086402:SARS-CoV-2; D000093485:COVID-19 Drug Treatment | Life sciences | 2,020 | D000998:Antiviral Agents; D019384:Nucleic Acid Synthesis Inhibitors; D009705:Nucleosides; D012324:RNA-Dependent RNA Polymerase |
Unraveling cancer risk with cellular and molecular tools. | Innovative techniques and mechanistic insights are reducing uncertainties in risk assessments. | 10.1021/es983625u | 21,651,006 | Environmental science & technology | 1,998 | ||
NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. | DCs activate NK cells during innate immune responses to viral infections. However, the composition and kinetics of the immunological synapse mediating this interaction are largely unknown. Here, we report the rapid formation of an immunological synapse between human resting NK cells and mature DCs. Although inhibitory ... | 10.1172/JCI31751 | 17,948,125 | D000818:Animals; D015703:Antigens, CD; D017209:Apoptosis; D015415:Biomarkers; D002450:Cell Communication; D002470:Cell Survival; D002478:Cells, Cultured; D018920:Coculture Techniques; D003713:Dendritic Cells; D006801:Humans; D007113:Immunity, Innate; D053720:Interleukin-15 Receptor alpha Subunit; D007694:Killer Cells, ... | The Journal of clinical investigation | 2,007 | D015703:Antigens, CD; D015415:Biomarkers; D053720:Interleukin-15 Receptor alpha Subunit |
The metabolic cost of breathing in critical surgical patients. | Twenty ventilator-dependent patients, 14 male and six female, age 47.9 +/- 14, status post polytrauma (14), emergency surgery (three), and coronary artery bypass (three) were evaluated to compare measured energy expenditure (MEE) between the intermittent mandatory ventilation mode (IMV) and assist mode ventilation (AMV... | 10.1097/00005373-198512000-00002 | 4,068,066 | D000328:Adult; D002151:Calorimetry; D003422:Critical Care; D004734:Energy Metabolism; D005260:Female; D013502:General Surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial | The Journal of trauma | 1,985 | |
Photoinduced Controlled/Living Polymerizations. | The application of photochemistry in polymer synthesis is of interest due to the unique possibilities offered compared to thermochemistry, including topological and temporal control, rapid polymerization, sustainable low-energy processes, and environmentally benign features leading to established and emerging applicati... | 10.1002/anie.202117377 | 35,128,771 | D015394:Molecular Structure; D010777:Photochemistry; D058105:Polymerization; D011108:Polymers | Angewandte Chemie (International ed. in English) | 2,022 | D011108:Polymers |
Spontaneously immortalised bovine mammary epithelial cells exhibit a distinct gene expression pattern from the breast cancer cells. | BACKGROUND
Spontaneous immortalisation of cultured mammary epithelial cells (MECs) is an extremely rare event, and the molecular mechanism behind spontaneous immortalisation of MECs is unclear. Here, we report the establishment of a spontaneously immortalised bovine mammary epithelial cell line (BME65Cs) and the change... | 10.1186/1471-2121-11-82 | 20,969,773 | D000818:Animals; D001943:Breast Neoplasms; D002417:Cattle; D045744:Cell Line, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004268:DNA-Binding Proteins; D015536:Down-Regulation; D004847:Epithelial Cells; D005260:Female; D020869:Gene Expression Profiling; D006801:H... | BMC cell biology | 2,010 | C091732:BCL2-associated athanogene 1 protein; D019941:Cyclin-Dependent Kinase Inhibitor p16; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004268:DNA-Binding Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D... |
[Electrophoretic study of the proteins from Actinidia leaves and sex identification]. | The protein composition of actinidia (Actinidia L.) leaves has been studied by SDS-PAGE. Specific polypeptides in the protein pattern of male and female plants belonging to two species, A. kolomikta and A. chinensis, were detected. The potential of biochemical protein markers for identification of the plant sex is disc... | 16,521,588 | D029042:Actinidia; D004591:Electrophoresis, Polyacrylamide Gel; D018515:Plant Leaves; D010940:Plant Proteins | Prikladnaia biokhimiia i mikrobiologiia | 2,006 | D010940:Plant Proteins | |
Face recognition: a model specific ability. | In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general ... | 10.3389/fnhum.2014.00769 | 25,346,673 | Frontiers in human neuroscience | 2,014 | ||
Human marrow stromal precursors are alpha 1 integrin subunit-positive. | In this work we studied the expression of adhesion molecules on primate human and non-human marrow stromal cells (primary cultures and lines) and on human CD34(+) hematopoietic normal and leukemic precursors. Differential expression of alpha1 integrin subunit was observed, since this molecule was intensely expressed by... | 10.1002/1097-4652(200009)184:3<319::AID-JCP5>3.0.CO;2-N | 10,911,362 | D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D002460:Cell Line; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells; D006801:Humans; D039423:Integrin alpha1; D007938:Leukemia; D010641:Phenotype; D011323:Primates | Journal of cellular physiology | 2,000 | D015703:Antigens, CD; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D039423:Integrin alpha1 |
Late Quaternary climate change and spatial genetic structure in the shrub Banksia hookeriana. | Spatial genetic variation within species is influenced by both contemporary and historical factors. We attempted to assess the impact of increased aridity and lower temperatures associated with the last glacial maximum on possible refugia and the structuring of genetic variation in Banksia hookeriana, a shrub species r... | 10.1111/j.1365-294X.2006.02860.x | 16,599,971 | D000704:Analysis of Variance; D002980:Climate; D005843:Geography; D010802:Phylogeny; D011110:Polymorphism, Genetic; D039105:Proteaceae; D014904:Western Australia | Molecular ecology | 2,006 | |
Diastereo- and enantioselective conjugate addition of alpha-ketoesters to nitroalkenes catalyzed by a chiral Ni(OAc)(2) complex under mild conditions. | A highly efficient, catalytic, diastereo- and enantioselective conjugate addition of alpha-ketoesters to nitroalkenes has been devised. The reaction was applicable to various substrates. Notably, the combination of endogenous and exogenous bases was effective, allowing a small amount of the catalyst (0.1-1 mol % Ni) to... | 10.1021/ja909457b | 20,199,025 | D000085:Acetates; D000475:Alkenes; D002384:Catalysis; D004952:Esters; D007659:Ketones; D015394:Molecular Structure; D009532:Nickel; D009574:Nitro Compounds; D013237:Stereoisomerism | Journal of the American Chemical Society | 2,010 | D000085:Acetates; D000475:Alkenes; D004952:Esters; D007659:Ketones; D009574:Nitro Compounds; D009532:Nickel |
Applications of gold(I) alkynyl systems: a growing field to explore. | Gold(I) alkynyl complexes present a growing research field with respect to their very wide range of applications in different areas such as luminescence, molecular recognition, optical switches, electronics and catalysis. Biological applications are also being developed in the recent years, where these complexes are us... | 10.1039/c1cs15123a | 21,769,365 | D000480:Alkynes; D002384:Catalysis; D056831:Coordination Complexes; D004581:Electronics; D006046:Gold; D050866:Liquid Crystals; D049408:Luminescent Agents; D055096:Optical Devices | Chemical Society reviews | 2,011 | D000480:Alkynes; D056831:Coordination Complexes; D049408:Luminescent Agents; D006046:Gold |
Sugar inhibits the production of the toxins that trigger clostridial gas gangrene. | Histotoxic strains of Clostridium perfringens cause human gas gangrene, a devastating infection during which potent tissue-degrading toxins are produced and secreted. Although this pathogen only grows in anaerobic-nutrient-rich habitats such as deep wounds, very little is known regarding how nutritional signals influen... | 10.1016/j.micpath.2011.10.008 | 22,079,896 | D001426:Bacterial Proteins; D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D002460:Cell Line; D003016:Clostridium perfringens; D015536:Down-Regulation; D005738:Gas Gangrene; D015964:Gene Expression Regulation, Bacterial; D005947:Glucose; D006460:Hemolysin Proteins; D006801:Humans; D013395:Sucrose; D010738:... | Microbial pathogenesis | 2,012 | D001426:Bacterial Proteins; D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D006460:Hemolysin Proteins; D013395:Sucrose; C020452:Clostridium perfringens theta-toxin; D010738:Type C Phospholipases; C040649:alpha toxin, Clostridium perfringens; D005947:Glucose |
The microenvironment controls invadosome plasticity. | Invadosomes are actin-based structures involved in extracellular matrix degradation. Invadosomes is a term that includes podosomes and invadopodia, which decorate normal and tumour cells, respectively. They are mainly organised into dots or rosettes, and podosomes and invadopodia are often compared and contrasted. Vari... | 10.1242/jcs.182329 | 27,029,343 | D000199:Actins; D000818:Animals; D060833:Cellular Microenvironment; D024042:Collagen Type I; D055354:Exosomes; D005109:Extracellular Matrix; D006801:Humans | Journal of cell science | 2,016 | D000199:Actins; D024042:Collagen Type I |
The use of 2,2'-dithiobis(5-nitropyridine) (DTNP) for deprotection and diselenide formation in protected selenocysteine-containing peptides. | In contrast to the large number of sidechain protecting groups available for cysteine derivatives in solid phase peptide synthesis, there is a striking paucity of analogous selenocysteine Se-protecting groups in the literature. However, the growing interest in selenocysteine-containing peptides and proteins requires a ... | 10.1002/psc.1430 | 22,249,911 | D003500:Cyclization; D010455:Peptides; D011725:Pyridines; D017279:Selenocysteine; D051140:Selenoproteins; D060327:Solid-Phase Synthesis Techniques | Journal of peptide science : an official publication of the European Peptide Society | 2,012 | D010455:Peptides; D011725:Pyridines; D051140:Selenoproteins; D017279:Selenocysteine; C011801:2,2'-dithiobis(5-nitropyridine) |
Expression of the murine CD27 ligand CD70 in vitro and in vivo. | The interaction between TNFR family member CD27 and its ligand CD70 promotes lymphocyte expansion and effector cell formation. In humans, control of CD27 function is partly regulated by the restricted expression of CD70. We used newly developed mAbs to characterize murine (m) CD70 expression in vitro and in vivo. On re... | 10.4049/jimmunol.170.1.33 | 12,496,380 | D000818:Animals; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D001402:B-Lymphocytes; D053282:CD27 Ligand; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D006825:Hybridomas; D009980:Influenza A virus; D007251:Influenza, Human; D008024:Ligands; D008168:Lung; D008198:Lymph Nodes; D008213:Lymphocyte Activ... | Journal of immunology (Baltimore, Md. : 1950) | 2,003 | D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D053282:CD27 Ligand; C505771:CD70 protein, human; C505772:Cd70 protein, mouse; D008024:Ligands; D008565:Membrane Proteins |
The role of antiphospholipid antibodies (aPls) in infertile women: the long-lasting experience. | Antiphospholipid antibodies (aPls) are generally characterized as heterogeneous and non-specific autoantibodies directed against various phospholipids such as cardiolipin, ph-serine, ph-inositol, ph-acid, ph-glycerol, ph-sphyngomyelin, ph-choline, annexins, and co-factor β2-glycoprotein I. aPls occur not only during au... | 10.1007/s12522-014-0196-y | 29,259,402 | Reproductive medicine and biology | 2,015 | ||
Hydrophobic Coatings on Cotton Obtained by in Situ Plasma Polymerization of a Fluorinated Monomer in Ethanol Solutions. | Plasma polymerization using hydrophobic monomers in the gas phase is a well-known technology to generate hydrophobic coatings. However, synthesis of functional hydrophobic coatings using plasma technology in liquids has not yet been accomplished. This work is consequently focused on polymerization of a liquid fluorinat... | 10.1021/acsami.6b15812 | 28,117,568 | ACS applied materials & interfaces | 2,017 | ||
Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression. | Reactive oxygen species (ROS) generated during photodynamic therapy (PDT) can trigger autophagy. However, little research is focused on whether there is a synergistic anticancer effect with PDT if extra autophagy promoter or inhibitor is added. Here, it is found that autophagy promotion significantly enhances the PDT a... | 10.1002/smll.201802337 | 30,152,186 | D001343:Autophagy; D045744:Cell Line, Tumor; D050091:Dendrimers; D006801:Humans; D007211:Indoles; D054833:Isoindoles; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species | Small (Weinheim an der Bergstrasse, Germany) | 2,018 | D050091:Dendrimers; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; C013647:phthalocyanine |
Maltreatment-associated psychiatric problems: an example of environmentally triggered ESSENCE? | This paper presents a new concept-maltreatment associated psychiatric problems (MAPP)-a syndrome of overlapping complex neurodevelopmental problems in children who have experienced abuse or neglect in early life. Children with MAPP are a hidden population in the community and, in clinical settings, their problems can s... | 10.1155/2013/148468 | 23,710,133 | D002648:Child; D002649:Child Abuse; D002665:Child Psychiatry; D006801:Humans; D001523:Mental Disorders; D008959:Models, Neurological; D009460:Neurologic Examination; D013577:Syndrome | TheScientificWorldJournal | 2,013 | |
Rab-like protein 1 A is upregulated by cisplatin treatment and partially inhibits chemoresistance by regulating p53 activity. | Rab-like protein 1 A (RBEL1A), which is a predominant isoform of RBEL1, has been identified to serve an important function in breast tumorigenesis and may be upregulated in breast tumor cells. RBEL1A may block the transcriptional activity of p53, which is important in the induction of cisplatin sensitivity. Previous st... | 10.3892/ol.2018.9205 | 30,197,676 | Oncology letters | 2,018 | ||
Comprehensive Evaluation of the Safety and Efficacy of BAFASAL® Bacteriophage Preparation for the Reduction of Salmonella in the Food Chain. | Bacteriophages are bacterial predators, which are garnering much interest nowadays vis-à-vis the global phenomenon of antimicrobial resistance. Bacteriophage preparations seem to be an alternative to antibiotics, which can be used at all levels of the food production chain. Their safety and efficacy, however, are of pu... | 10.3390/v12070742 | 32,664,206 | D000818:Animals; D000900:Anti-Bacterial Agents; D002432:Cecum; D002645:Chickens; D005260:Female; D020387:Food Chain; D005506:Food Contamination; D005516:Food Microbiology; D011201:Poultry Diseases; D051381:Rats; D017208:Rats, Wistar; D012475:Salmonella; D012483:Salmonella Phages | Viruses | 2,020 | D000900:Anti-Bacterial Agents |
Prognosis Factors of Patients Undergoing Renal Replacement Therapy. | BACKGROUND
Survival in patients with end-stage kidney disease (ESKD) on renal replacement therapy (RRT) is less than that of the general population of the same age, and depends on patient factors, the medical care received, and the type of RRT used. The objective of this study is to analyze the factors associated with ... | 10.3390/jpm13040605 | 37,108,991 | Journal of personalized medicine | 2,023 | ||
Eating attitude in patients with rheumatoid arthritis: The relationship between pain, body mass index, disease activity, functional status, depression, anxiety and quality of life. | PURPOSE
The aim of this study is to evaluate the relationship between eating attitude and pain, body mass index, disease activity, functional status, depression, anxiety and quality of life in patients with rheumatoid arthritis (RA).
DESIGN AND METHODS
This descriptive and cross-sectional study was conducted with 111... | 10.1016/j.apnu.2023.04.001 | 37,197,863 | D006801:Humans; D011788:Quality of Life; D003863:Depression; D003430:Cross-Sectional Studies; D015992:Body Mass Index; D000085542:Functional Status; D001007:Anxiety; D010146:Pain; D001172:Arthritis, Rheumatoid; D001290:Attitude | Archives of psychiatric nursing | 2,023 | |
[Canalith repositioning maneuver: proposal of a new therapy for benign paroxysmal positional vertigo of the posterior semicircular canal]. | A new therapy is proposed for the treatment of Benign Paroxysmal Positional Vertigo (B.P.P.V.) of the Posterior Semicircular Canal (P.S.C.): the Canalith Repositioning Maneuver (C.R.M.). The need for a new maneuver to treat B.P.P.V. of the P.S.C. arises from the difficulties encountered in daily practice, under particu... | 10,361,743 | D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture; D012189:Retrospective Studies; D012665:Semicircular Canals; D016896:Treatment Outcome; D014717:Vertigo | Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale | 1,998 | ||
Subpulmonary and subaortic ridges in doubly committed subarterial ventricular septal defect: an echocardiographic study. | BACKGROUND
Certain conditions, including discrete subaortic stenosis and right ventricular outflow tract obstruction are well-known associations with ventricular septal defect. However, the association of discrete type subpulmonary and subaortic stenosis with ventricular septal defect has not been described to date.
... | 10.1093/oxfordjournals.eurheartj.a014976 | 8,781,834 | D000293:Adolescent; D001024:Aortic Valve Stenosis; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006345:Heart Septal Defects, Ventricular; D006801:Humans; D008297:Male; D011662:Pulmonary Subvalvular Stenosis; D012680:Sensitivity and Specificity | European heart journal | 1,996 | |
Total homocysteine levels and cardiovascular risk factors in healthy Tunisians. | Hyperhomocysteinaemia is considered as an important independent risk factor for atherosclerosis and thrombotic disease. This study determined the distribution of homocysteine (Hcy) levels in healthy Tunisian subjects and evaluated the relationship between Hcy levels and some cardiovascular risk factors. Randomly select... | 10.26719/2011.17.12.937 | 22,355,947 | D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases; D005260:Female; D006710:Homocysteine; D006801:Humans; D020138:Hyperhomocysteinemia; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014416:Tunisia | Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit | 2,011 | D006710:Homocysteine |
Significance and Role of Pattern Recognition Receptors in Malignancy. | Pattern recognition receptors (PRRs) are members of innate immunity, playing pivotal role in several immunological reactions. They are known to act as a bridge between innate and adaptive immunity. They are expressed on several normal cell types but have been shown with increasing frequency on/in tumor cells. Significa... | 10.1007/s00005-019-00540-x | 30,976,817 | D056704:Adaptive Immunity; D000818:Animals; D000074322:Antineoplastic Agents, Immunological; D004247:DNA; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy; D008024:Ligands; D016246:Lymphocytes, Tumor-Infiltrating; D009369:Neoplasms; D012313:RNA; D051192:Receptors, Pattern ... | Archivum immunologiae et therapiae experimentalis | 2,019 | D000074322:Antineoplastic Agents, Immunological; D008024:Ligands; D051192:Receptors, Pattern Recognition; D012313:RNA; D004247:DNA |
Magnetite nanoparticles with aminomethylenephosphonic groups: synthesis, characterization and uptake of europium(III) ions from aqueous media. | Two adsorbents with covalently bound aminomethylenephosphonic acid functions (and referred to as MNPs/AMPA and MNPs/SiO2-AMPA) were synthesized from two types of amino-functionalized magnetic nanoparticles (MNPs) via Moedritzer-Irani reaction. The sorbents with anchored dopamine ligand (MNPs/dopa) or aminopropyl groups... | 10.1007/s00604-019-3520-8 | 31,250,114 | Mikrochimica acta | 2,019 | ||
Arterial spin labeling versus bolus-tracking perfusion in hyperacute stroke. | BACKGROUND AND PURPOSE
Arterial spin labeling (ASL) is a perfusion magnetic resonance imaging (MRI) technique that does not require contrast administration and thus may be more practical in hyperacute stroke than susceptibility-weighted bolus-tracking perfusion-weighted imaging (PWI). However, a threshold for ASL measu... | 10.1161/STROKEAHA.113.003218 | 24,302,482 | D019540:Area Under Curve; D016001:Confidence Intervals; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D011446:Prospective Studies; D012372:ROC Curve; D013113:Spin Labels; D020521:Stroke; D015912:Thrombolytic Therapy; D01405... | Stroke | 2,014 | D013113:Spin Labels |
Clot-entrapped blood cells in synergy with human mesenchymal stem cells create a pro-angiogenic healing response. | Blood clots stop bleeding and provide cell-instructive microenvironments. Still, in vitro models used to study implant performance typically neglect any possible interactions of recruited cells with surface-adhering blood clots. Here we study the interaction and synergies of bone marrow derived human mesenchymal stem c... | 10.1039/c7bm00276a | 28,809,406 | D000469:Alkaline Phosphatase; D002454:Cell Differentiation; D018920:Coculture Techniques; D005109:Extracellular Matrix; D005353:Fibronectins; D006801:Humans; D020778:Matrix Metalloproteinase 2; D059630:Mesenchymal Stem Cells; D018919:Neovascularization, Physiologic; D010012:Osteogenesis; D013927:Thrombosis; D014945:Wou... | Biomaterials science | 2,017 | D005353:Fibronectins; D000469:Alkaline Phosphatase; D020778:Matrix Metalloproteinase 2 |
Discovering Digital Biomarkers of Panic Attack Risk in Consumer Wearables Data. | Panic attacks are an impairing mental health problem that impacts more than one out of every 10 adults in the United States (US). Clinical guidelines suggest panic attacks occur without warning and their unexpected nature worsens their impact on quality of life. Individuals who experience panic attacks would benefit fr... | 10.1109/EMBC40787.2023.10339982 | 38,083,448 | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference | 2,023 | ||
Gene structure of rat testicular cell adhesion molecule 1 (TCAM-1), and its physical linkage to genes coding for the growth hormone and BAF60b, a component of SWI/SNF complexes. | In the +9.7 to +21.7kb downstream region from the transcriptional start site of the rat growth hormone (GH) gene, a gene specifically expressed in the testis was found to have reverse transcriptional orientation to the GH gene. Its exon comprised 2693 bases encoded a protein having 548 amino acids (60479Da). The amino ... | 10.1016/s0378-1119(98)00524-1 | 9,889,334 | D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015815:Cell Adhesion Molecules; D002874:Chromosome Mapping; D008040:Genetic Linkage; D013006:Growth Hormone; D007136:Immunoglobulins; D018799:Intercellular Adhesion Molecule-1; D008297:Male; D008565:Membrane Proteins; D008969:Molecular Sequence Data;... | Gene | 1,999 | D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D008565:Membrane Proteins; C491650:Smarcd2 protein, rat; C485519:TCAM1P protein, human; C117328:Tcam1 protein, rat; D014157:Transcription Factors; D018799:Intercellular Adhesion Molecule-1; D013006:Growth Hormone |
[Chronic Kidney Disease:Key Points for Intraoperative and Postoperative Management]. | Chronic kidney disease( CKD) is a challenge in cardiac surgery in elderly patients, making intraoperative and postoperative management critical. Although sodium glucose co-transporter 2( SGLT2) inhibitors have nephroprotective effects, it's important to discontinue them three days before surgery and resume them when fo... | 38,056,834 | D006801:Humans; D000368:Aged; D051436:Renal Insufficiency, Chronic; D006435:Renal Dialysis; D007676:Kidney Failure, Chronic; D007362:Intensive Care Units | Kyobu geka. The Japanese journal of thoracic surgery | 2,023 | ||
Integrating transcription-factor abundance with chromatin accessibility in human erythroid lineage commitment. | Master transcription factors (TFs) directly regulate present and future cell states by binding DNA regulatory elements and driving gene-expression programs. Their abundance influences epigenetic priming to different cell fates at the chromatin level, especially in the context of differentiation. In order to link TF pro... | 10.1016/j.crmeth.2022.100188 | 35,463,156 | D006801:Humans; D014157:Transcription Factors; D002843:Chromatin; D019070:Cell Lineage; D005786:Gene Expression Regulation; D004247:DNA | Cell reports methods | 2,022 | D014157:Transcription Factors; D002843:Chromatin; D004247:DNA |
The merG gene product is involved in phenylmercury resistance in Pseudomonas strain K-62. | The physiological function of a new gene, hereby designated merG, located between merA and merB on the broad-spectrum mer operon of Pseudomonas strain K-62 plasmid pMR26 was investigated. The 654-bp merG gene encodes a protein with a canonical leader sequence at its N terminus. The processing of the signal peptide of t... | 10.1128/JB.181.3.726-730.1999 | 9,922,233 | D001426:Bacterial Proteins; D001692:Biological Transport; D003001:Cloning, Molecular; D004352:Drug Resistance, Microbial; D004926:Escherichia coli; D017353:Gene Deletion; D007700:Kinetics; D008190:Lyases; D008628:Mercury; D009876:Operon; D010663:Phenylmercury Compounds; D010957:Plasmids; D015221:Potassium Channels; D01... | Journal of bacteriology | 1,999 | D001426:Bacterial Proteins; C117243:MerG protein, Pseudomonas; D010663:Phenylmercury Compounds; D015221:Potassium Channels; D011993:Recombinant Fusion Proteins; D008190:Lyases; C097247:MerB protein, Bacteria; D008628:Mercury |
pH-lactate dissociation during anoxic insult: taurine effect. | Taurine, a sulfur amino acid abundant in brain of the fetus and early day neonate, has been postulated to play a major role in mediating the immature brain's unusually high buffering ability for lactic acidosis reported previously. In this study, we directly investigated this 'taurine effect' using a 10-day-old rat pup... | 10.1097/00001756-199106000-00006 | 1,912,466 | D000255:Adenosine Triphosphate; D000818:Animals; D001923:Brain Chemistry; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia; D007773:Lactates; D009682:Magnetic Resonance Spectroscopy; D010725:Phosphocreatine; D010759:Phosphorus Isotopes; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration; D013654:Taurine | Neuroreport | 1,991 | D007773:Lactates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D013654:Taurine; D000255:Adenosine Triphosphate |
The interaction of genes and smoking on forced expiratory volume: a classic twin study. | BACKGROUND
Genetic influences on lung function as measured by FEV1 have been reported from twin and family studies. The aims of this study were to estimate heritability of the ratio of measured FEV1 (mFEV1) to expected FEV(1) (eFEV1) in a white population, and to examine the interaction between genetic factors and smok... | 10.1378/chest.07-1438 | 17,989,158 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003627:Data Interpretation, Statistical; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking; D013147:Spirometry; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D006113:Un... | Chest | 2,007 | |
Oligonucleotides are potent antioxidants acting primarily through metal ion chelation. | We report on a rather unknown feature of oligonucleotides, namely, their potent antioxidant activity. Previously, we showed that nucleotides are potent antioxidants in Fe(II)/Cu(I/II)-H(2)O(2) systems. Here, we explored the potential of 2'-deoxyoligonucleotides as inhibitors of the Fe(II)/Cu(I/II)-induced *OH formation... | 10.1007/s00775-010-0628-z | 20,155,378 | D000975:Antioxidants; D001482:Base Composition; D002614:Chelating Agents; D004305:Dose-Response Relationship, Drug; D004578:Electron Spin Resonance Spectroscopy; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical; D009682:Magnetic Resonance Spectroscopy; D008670:Metals; D009584:Nitrogen; D009841:Oligonucleotides; D010... | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry | 2,010 | D000975:Antioxidants; D002614:Chelating Agents; D008670:Metals; D009841:Oligonucleotides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D009584:Nitrogen |
Understanding the biases of generalised recombination: part I. | This is the first part of a two-part paper where we propose, model theoretically and study a general notion of recombination for fixed-length strings, where homologous recombination, inversion, gene duplication, gene deletion, diploidy and more are just special cases. The analysis of the model reveals that the notion o... | 10.1162/evco.2006.14.4.411 | 17,109,605 | D000465:Algorithms; D015982:Bias; D005075:Biological Evolution; D019295:Computational Biology; D008957:Models, Genetic; D011995:Recombination, Genetic | Evolutionary computation | 2,006 | |
Haemostasis prophylaxis using single dose desmopressin acetate and extended use epsilon aminocaproic acid for adenotonsillectomy in patients with type 1 von Willebrand disease. | In patients with confirmed or suspected type 1 von Willebrand disease (VWD), adenotonsillectomy has been reported to be associated with a rate of peri-operative hemorrhage between 8 and 23%. Desmopressin acetate (DDAVP, 1-deamino 8-D arginine- vasopressin) is the treatment of choice for type 1 patients with baseline vo... | 10.1111/j.1365-2516.2011.02619.x | 21,771,208 | D000233:Adenoidectomy; D000293:Adolescent; D015119:Aminocaproic Acid; D000933:Antifibrinolytic Agents; D002648:Child; D002675:Child, Preschool; D003894:Deamino Arginine Vasopressin; D003692:Delayed-Action Preparations; D005260:Female; D006490:Hemostatics; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; ... | Haemophilia : the official journal of the World Federation of Hemophilia | 2,012 | D000933:Antifibrinolytic Agents; D003692:Delayed-Action Preparations; D006490:Hemostatics; D003894:Deamino Arginine Vasopressin; D015119:Aminocaproic Acid |
Alteration of Electronic Band Structure via a Metal-Semiconductor Interfacial Effect Enables High Faradaic Efficiency for Electrochemical Nitrogen Fixation. | The interface engineering strategy has been an emerging field in terms of material improvisation that not only alters the electronic band structure of a material but also induces beneficial effects on electrochemical performances. Particularly, it is of immense importance for the environmentally benign electrochemical ... | 10.1021/acsnano.1c08652 | 34,894,661 | ACS nano | 2,021 | ||
All-atom simulations and free-energy calculations of coiled-coil peptides with lipid bilayers: binding strength, structural transition, and effect on lipid dynamics. | Peptides E and K, which are synthetic coiled-coil peptides for membrane fusion, were simulated with lipid bilayers composed of lipids and cholesterols at different ratios using all-atom models. We first calculated free energies of binding from umbrella sampling simulations, showing that both E and K peptides tend to ad... | 10.1038/srep22299 | 26,926,570 | D002784:Cholesterol; D003198:Computer Simulation; D004745:Enkephalins; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008051:Lipid Bilayers; D008561:Membrane Fusion; D056004:Molecular Dynamics Simulation; D010446:Peptide Fragments; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D... | Scientific reports | 2,016 | D004745:Enkephalins; C551850:FSPQMLQDIIEKKTKIL; D008051:Lipid Bilayers; D010446:Peptide Fragments; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D023083:beta-Defensins; C094877:dioleoyl phosphatidylethanolamine; C039933:peptide E (adrenal medulla); D002784:Cholesterol; C017251:1,2-oleoylphosphatidylc... |
Effect of Suture Used for Closure of Mesenteric Defects After Laparoscopic Roux-en-Y Gastric Bypass: Single-Center Study. | INTRODUCTION
Small bowel obstruction (SBO) due to internal herniation (IH) is a well-known complication of laparoscopic Roux-en-Y gastric bypass (LRYGBP). The objective of this study is to evaluate different types of non-absorbable sutures used for closure of the defects regarding the incidence of SBO due to IH/adhesio... | 10.1007/s11695-022-06411-3 | 36,564,621 | D006801:Humans; D015390:Gastric Bypass; D012189:Retrospective Studies; D009767:Obesity, Morbid; D011126:Polypropylenes; D011183:Postoperative Complications; D007415:Intestinal Obstruction; D000267:Tissue Adhesions; D006547:Hernia; D010535:Laparoscopy; D013537:Sutures | Obesity surgery | 2,023 | D011126:Polypropylenes |
Association Between Pressure Support During Extubation Readiness Testing and Time to First Extubation in Children With Congenital Heart Disease. | BACKGROUND
Extubation readiness testing (ERT) is often performed in children with congenital heart disease prior to liberation from mechanical ventilation. The ideal ERT method in this population is unknown. We recently changed our ERT method from variable (10, 8, or 6 cm H2O, depending on endotracheal tube size) to fi... | 10.4187/respcare.10251 | 36,414,274 | D006801:Humans; D002648:Child; D015300:Ventilator Weaning; D060666:Airway Extubation; D011175:Positive-Pressure Respiration; D012121:Respiration, Artificial; D006330:Heart Defects, Congenital | Respiratory care | 2,023 | |
Topological degeneracy (Majorana zero-mode) and 1 + 1D fermionic topological order in a magnetic chain on superconductor via spontaneous Z₂(f) symmetry breaking. | We study a chain of ferromagnetic sites, ie nano-particles, molecules or atoms, on a substrate of fully gapped superconductors. We find that under quite realistic conditions, the fermion-number-parity symmetry Z₂(f) can spontaneously break. In other words, such a chain can realize a 1 + 1D fermionic topologically ord... | 10.1088/0953-8984/27/40/405601 | 26,401,725 | Journal of physics. Condensed matter : an Institute of Physics journal | 2,015 | ||
Hypoplastic left heart syndrome with premature closure of foramen ovale: report of an unusual type of totally anomalous pulmonary venous return. | We report on a case of hypoplastic left heart syndrome (HLHS), associated with premature closure of the foramen ovale and an unusual type of totally anomalous pulmonary venous return. The existence of an anomalous connection of the right upper pulmonary vein to the superior vena cava-right atrial (SVC-RA) junction and ... | 10.1007/BF02058329 | 2,354,986 | D000015:Abnormalities, Multiple; D001021:Aortic Valve; D015150:Echocardiography, Doppler; D005260:Female; D006330:Heart Defects, Congenital; D006346:Heart Septum; D006352:Heart Ventricles; D006801:Humans; D007231:Infant, Newborn; D008943:Mitral Valve; D011667:Pulmonary Veins; D013577:Syndrome | Heart and vessels | 1,990 | |
Analyzing reflective narratives to assess the ethical reasoning of pediatric residents. | A limiting factor in ethics education in medical training has been difficulty in assessing competence in ethics. This study was conducted to test the concept that content analysis of pediatric residents' personal reflections about ethics experiences can identify changes in ethical sensitivity and reasoning over time. A... | 10.1353/nib.2013.0034 | 24,407,089 | D026688:Bioethical Issues; D002648:Child; D002983:Clinical Competence; D003479:Curriculum; D004521:Educational Measurement; D004992:Ethics, Medical; D006801:Humans; D007396:Internship and Residency; D009014:Morals; D033262:Narration; D010372:Pediatrics; D010820:Physicians; D013850:Thinking | Narrative inquiry in bioethics | 2,013 | |
Doxycycline reduces the migration of tuberous sclerosis complex-2 null cells - effects on RhoA-GTPase and focal adhesion kinase. | Lymphangioleiomyomatosis (LAM) is associated with dysfunction of the tuberous sclerosis complex (TSC) leading to enhanced cell proliferation and migration. This study aims to examine whether doxycycline, a tetracycline antibiotic, can inhibit the enhanced migration of TSC2-deficient cells, identify signalling pathways ... | 10.1111/jcmm.12593 | 26,282,580 | D000818:Animals; D004318:Doxycycline; D051418:Focal Adhesion Kinase 2; D018192:Lymphangioleiomyomatosis; D051379:Mice; D051381:Rats; D020123:Sirolimus; D014402:Tuberous Sclerosis; D054460:rho-Associated Kinases | Journal of cellular and molecular medicine | 2,015 | D051418:Focal Adhesion Kinase 2; D054460:rho-Associated Kinases; D004318:Doxycycline; D020123:Sirolimus |
Possible intramural site of reentrant circuit in ventricular tachycardia of nonischemic cause. Pre and intraoperative mapping studies. | A patient with a drug-refractory sustained ventricular tachycardia (VT) of nonischemic cause was mapped for the site of VT origin. The intraoperative mapping showed the earliest site of activation of VT on the epicardial surface at which the initial deflection of the local electrogram preceded the onset of the QRS comp... | 10.1536/ihj.33.505 | 1,453,556 | D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D004568:Electrodiagnosis; D004594:Electrophysiology; D006321:Heart; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular | Japanese heart journal | 1,992 | |
Differences in ME and CFS Symptomology in Patients with Normal and Abnormal Exercise Test Results. | Post-exertional malaise (PEM) is a cardinal symptom of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS), which often distinguishes patients with this illness from healthy controls or individuals with exclusionary illnesses such as depression. However, occurrence rates for PEM fluctuate from subject to ... | 10.23937/2378-3001/4/1/1066 | 28,713,856 | International journal of neurology and neurotherapy | 2,017 | ||
Pediatric Resuscitation Education in Low-Middle-Income Countries: Effective Strategies for Successful Program Development. | Despite established international guidelines, there is considerable variability in the quality of resuscitative care received by critically ill children in low-middle-income countries. While this problem is certainly multifactorial, education of health care workers is an important determinant of care quality. This arti... | 10.1055/s-0036-1584673 | 31,073,421 | Journal of pediatric intensive care | 2,017 | ||
Prolactin and psychophysiologic measures after single doses of thioridazine. | Six normal men ingested thioridazine, high and low doses, and placebo on three occasions. Their plasma and urinary thioridazine and mesoridazine plus sulforidazine were measured over 5 hr, together with their plasma prolactin, and a battery of psychophysiologic variables. Drowsiness and EEG changes correlated highly wi... | 10.1002/cpt1977214422 | 849,673 | D000328:Adult; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006801:Humans; D008297:Male; D009048:Motor Skills; D010919:Placebos; D011388:Prolactin; D011581:Psychological Tests; D011603:Psychophysiology; D011930:Reaction Time; D012890:Sleep; D013881:Thioridazine | Clinical pharmacology and therapeutics | 1,977 | D010919:Placebos; D011388:Prolactin; D013881:Thioridazine |
Liver cirrhosis, other liver diseases, and risk of hospitalisation for intracerebral haemorrhage: a Danish population-based case-control study. | BACKGROUND
Liver diseases are suspected risk factors for intracerebral haemorrhage (ICH). We conducted a population-based case-control study to examine risk of ICH among hospitalised patients with liver cirrhosis and other liver diseases.
METHODS
We used data from the hospital discharge registries (1991-2003) and the... | 10.1186/1471-230X-8-16 | 18,501,016 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage; D003718:Denmark; D005260:Female; D006753:Hospital Records; D006801:Humans; D008103:Liver Cirrhosis; D008104:Liver Cirrhosis, Alcoholic; D008107:Liver Diseases; D016015:Logistic Models; ... | BMC gastroenterology | 2,008 | |
Usefulness and pitfalls of MAA SPECT/CT in identifying digestive extrahepatic uptake when planning liver radioembolization. | PURPOSE
Identifying gastroduodenal uptake of (99m)Tc-macroaggregated albumin (MAA), which is associated with an increased risk of ulcer disease, is a crucial part of the therapeutic management of patients undergoing radioembolization for liver tumours. Given this context, the use of MAA single photon emission computed ... | 10.1007/s00259-011-2033-4 | 22,237,844 | D000368:Aged; D001692:Biological Transport; D004064:Digestive System; D004621:Embolization, Therapeutic; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011880:Radiotherapy Planning, Computer-Assi... | European journal of nuclear medicine and molecular imaging | 2,012 | D013438:Sulfhydryl Compounds; D013668:Technetium Tc 99m Aggregated Albumin; C082426:technetium Tc99m-mercaptoacetyl albumin |
Proximal promoter sequences mediate cell-specific and elevated expression of the favorable prognosis marker TrkA in human neuroblastoma cells. | The nerve growth factor receptor, TrkA, has a critical role in the survival, differentiation, and function of neurons in the peripheral and central nervous systems. Recent studies have demonstrated a strong correlation between abundant expression of TrkA and a favorable prognosis of the pediatric tumor, neuroblastoma. ... | 10.1074/jbc.273.1.39 | 9,417,044 | D006801:Humans; D009447:Neuroblastoma; D011401:Promoter Regions, Genetic; D020917:Receptor, trkA; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured | The Journal of biological chemistry | 1,998 | D020917:Receptor, trkA |
A randomised study comparing peripheral blood progenitor mobilisation using intermediate-dose cyclophosphamide plus lenograstim with lenograstim alone. | We conducted a prospective randomised study to compare the efficiency of out-patient progenitor cell mobilisation using either intermediate-dose cyclophosphamide (2 g/m(2)) and lenograstim at 5 micrograms/kg (Cyclo-G-CSF group, n=39) or lenograstim alone at 10 micrograms/kg (G-CSF group, n=40). The end points were to c... | 10.1038/sj.bmt.1704598 | 15,273,706 | D000276:Adjuvants, Immunologic; D000328:Adult; D000368:Aged; D001781:Blood Component Removal; D003520:Cyclophosphamide; D004359:Drug Therapy, Combination; D005260:Female; D006084:Graft Rejection; D016179:Granulocyte Colony-Stimulating Factor; D019337:Hematologic Neoplasms; D019650:Hematopoietic Stem Cell Mobilization; ... | Bone marrow transplantation | 2,004 | D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000078224:Lenograstim; D003520:Cyclophosphamide |
Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells. | Icb-1 (C1orf38) is a human gene initially described by our group to be involved in differentiation processes of cancer cells. To further elucidate the function of the icb-1 gene in differentiation of breast and endometrial cancer cells, we knocked down its expression by means of shRNA transfection. Knockdown of icb-1 i... | 10.3892/ijmm.2011.663 | 21,455,565 | D001943:Breast Neoplasms; D015820:Cadherins; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002762:Cholecalciferol; D047629:Estrogen Receptor beta; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D005833:Genital Neoplasms, Female; D006801:Humans; D047908:Intracellular S... | International journal of molecular medicine | 2,011 | D015820:Cadherins; D047629:Estrogen Receptor beta; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D034741:RNA, Small Interfering; C111850:THEMIS2 protein, human; D002762:Cholecalciferol; D014212:Tretinoin; D007781:Lactoferrin |
Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: Role of TGF-ß/Smads and Ang-1/Tie-2 signaling pathways. | Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses potent antidiabetic and wound healing activity. Aim: To evaluate the potential of hesperidin against experimentally induced diabetes foot u... | 10.17179/excli2018-1036 | 29,805,347 | EXCLI journal | 2,018 | ||
Imperatorin: A review of its pharmacology, toxicity and pharmacokinetics. | As a naturally occurring furanocoumarin, the medicinal value of imperatorin has been studied more and more. We hope to provide useful information for the further development of imperatorin by analyzing the literature of imperatorin in recent years. By collating the literature on the pharmacology of imperatorin, we foun... | 10.1016/j.ejphar.2020.173124 | 32,339,515 | D000818:Animals; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D011564:Furocoumarins; D006801:Humans; D018696:Neuroprotective Agents | European journal of pharmacology | 2,020 | D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D011564:Furocoumarins; D018696:Neuroprotective Agents; C031534:imperatorin |
Intrapolation and extrapolation of age-equivalent scores for the Bayley II: a comparison of two methods of estimation. | The Bayley Scales of Infant Development II (1) is a well established standardized test for assessing the mental ability of infants and young children. It provides an age-adjusted standard score as a summary measure, but for very low (or very high) functioning children the raw scores on this test may not allow the calcu... | 10.1097/00002826-199901000-00009 | 10,047,934 | D000367:Age Factors; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D016743:Mental Competency; D011580:Psychological Techniques; D012016:Reference Values | Clinical neuropharmacology | 1,999 | |
[Design of the system for detecting impedance cardiography based on windows plantform]. | In this paper is introduced systematically the design of the system for detecting impedance cardiography (ICG) based on Windows plantform. The three major ICG indexes of 30 students have been detected by the designed system in the clinical application, and conform with the results from the reference. On the other hand,... | 12,583,019 | D000328:Adult; D002307:Cardiography, Impedance; D004867:Equipment Design; D006801:Humans; D012815:Signal Processing, Computer-Assisted; D012984:Software; D012985:Software Design | Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation | 2,000 | ||
Erythrocyte membrane modification in malignant diseases of myeloid and lymphoreticular tissues. I. Tn-polyagglutination in acute myelocytic leukaemia. | Tn polyagglutination (persistent mixed-field polyagglutination) occurring in a patient with an acute myelocytic leukemia is described. The association of this RBC membrane change, thought to be due to somatic mutation at stem cell level, with a myeloproliferative disorder, has not been previously reported. | 10.1111/j.1365-2141.1976.tb03540.x | 1,063,594 | D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D002462:Cell Membrane; D004912:Erythrocytes; D006384:Hemagglutination; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D008297:Male; D008875:Middle Aged | British journal of haematology | 1,976 | D000017:ABO Blood-Group System; D001789:Blood Group Antigens |
Diet and prostate cancer - a holistic approach to management. | There is now increasing evidence from epidemiologic surveys and from laboratory, intervention, and case-control studies that diet and lifestyle plays a crucial role in prostate cancer biology and tumorigenesis. This applies to both the development and progression of prostate cancer, although in many cases the specific ... | 22,052,755 | D000230:Adenocarcinoma; D000975:Antioxidants; D015897:Comorbidity; D003611:Dairy Products; D004032:Diet; D004041:Dietary Fats; D019468:Disease Management; D006694:Holistic Health; D006801:Humans; D008297:Male; D008460:Meat; D009765:Obesity; D008517:Phytotherapy; D028321:Plant Preparations; D010945:Plants, Edible; D0190... | Archivos espanoles de urologia | 2,011 | D000975:Antioxidants; D004041:Dietary Fats; D028321:Plant Preparations | |
Identification of a nuclear protein, LRRC42, involved in lung carcinogenesis. | On the basis of the gene expression profiles of 120 lung cancer cases using a cDNA microarray containing 27,648 genes or expressed sequence tags (ESTs), we identified LRRC42 (Leucine-rich repeat containing 42) to be significantly upregulated in the majority of lung cancers. Northern blot analysis demonstrated that LRRC... | 10.3892/ijo.2014.2418 | 24,806,090 | D045744:Cell Line, Tumor; D002467:Cell Nucleus; D049109:Cell Proliferation; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004268:DNA-Binding Proteins; D050980:GATA Transcription Factors; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D057809:HEK29... | International journal of oncology | 2,014 | C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004268:DNA-Binding Proteins; D050980:GATA Transcription Factors; C468770:GATAD2B protein, human; C000594498:LRRC42 protein, human; C115369:MBD3 protein, human; D009687:Nuclear Proteins; D012097:Repressor Proteins |
The diagnostic value of circulating microRNAs for middle-aged (40-60-year-old) coronary artery disease patients. | OBJECTIVE
Circulating microRNAs have been recognized as promising biomarkers for various diseases. The present study aimed to explore the potential roles of circulating miR-149, miR-424 and miR-765 as non-invasive biomarkers for the diagnosis of coronary artery disease in middle-aged (40-60-year-old) patients.
METHOD... | 26,017,792 | D000367:Age Factors; D015415:Biomarkers; D016022:Case-Control Studies; D003324:Coronary Artery Disease; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and... | Clinics (Sao Paulo, Brazil) | 2,015 | D015415:Biomarkers; C551557:MIRN149 microRNA, human; C554214:MIRN424 microrna, human; C000600151:MIRN765 microRNA, human; D035683:MicroRNAs | |
An examination of factors potentially influencing birth distributions in golden snub-nosed monkeys (Rhinopithecus roxellana). | Many species of primates are considered seasonal breeders, but the set of factors, such as food availability, day length and temperature, that influence the timing of reproductive events for both wild and captive individuals remains unclear. Here, we examine the role of factors in shaping breeding patterns in Rhinopith... | 10.7717/peerj.2892 | 28,149,681 | PeerJ | 2,017 | ||
A Systematic Review Comparing Experimental Design of Animal and Human Methotrexate Efficacy Studies for Rheumatoid Arthritis: Lessons for the Translational Value of Animal Studies. | Increased awareness and understanding of current practices in translational research is required for informed decision making in drug development. This paper describes a systematic review of methotrexate for rheumatoid arthritis, comparing trial design between 147 animal and 512 human studies. Animal studies generally ... | 10.3390/ani10061047 | 32,560,528 | Animals : an open access journal from MDPI | 2,020 |
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