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Contraceptive use among young women in northern Ghana: a community-based study. | OBJECTIVE
The aim of the study was to assess factors influencing contraceptive uptake among young women aged 15-24 years in Bolgatanga Municipal District, northern Ghana.
METHODS
An analytical cross-sectional community-based study was conducted between December 2015 and April 2016. Participants (N = 580) were selecte... | 10.1080/13625187.2020.1783651 | 32,615,045 | D000293:Adolescent; D017677:Age Distribution; D003267:Contraception; D003268:Contraception Behavior; D003430:Cross-Sectional Studies; D005260:Female; D005869:Ghana; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D055815:Young Adult | The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception | 2,020 | |
Barriers to influenza vaccination of children hospitalised for acute respiratory illness: A cross-sectional survey. | AIM
To identify barriers to influenza vaccination of children hospitalised for acute respiratory illness in Australia.
METHODS
A total of 595 parents of children hospitalised with acute respiratory illness across five tertiary hospitals in 2019 participated in an online survey. Multivariate logistic regression identi... | 10.1111/jpc.15235 | 33,094,543 | D001315:Australia; D002648:Child; D003430:Cross-Sectional Studies; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human; D011795:Surveys and Questionnaires; D014611:Vaccination | Journal of paediatrics and child health | 2,021 | D007252:Influenza Vaccines |
Influence of Hospital Volume of Procedures by Year on the Risk of Revision of Total Hip and Knee Arthroplasties: A Propensity Score-Matched Cohort Study. | The volume of total hip (THA) and knee arthroplasties (TKA) performed in a hospital per year could be an influential factor on the revision of these procedures. The aims of this study were: To obtain comparable cohorts in higher- and lower-volume hospitals; and to assess the association between the hospital volume and ... | 10.3390/jcm8050670 | 31,086,009 | Journal of clinical medicine | 2,019 | ||
[Optic neuritis: aetiopathogenesis, diagnosis, prognosis and management]. | The main causes of optic neuritis (ON) are multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease, also known as MOGAD. When all screening is negative, we can speak of idiopathic ON, although this diagnosis should be provisional. ON can be diagno... | 10.33588/rn.7403.2021473 | 35,084,734 | D051401:Aquaporin 4; D001323:Autoantibodies; D005074:Evoked Potentials, Visual; D006801:Humans; D063308:Myelin-Oligodendrocyte Glycoprotein; D009471:Neuromyelitis Optica; D009902:Optic Neuritis; D011379:Prognosis; D012189:Retrospective Studies | Revista de neurologia | 2,022 | D051401:Aquaporin 4; D001323:Autoantibodies; D063308:Myelin-Oligodendrocyte Glycoprotein |
Sarcoid-Like Granulomatosis of the Lung Related to Durvalumab After Chemoradiation for Pulmonary Squamous Cell Carcinoma. | Sarcoid-like granulomatosis is a unique immune-related adverse event (irAE) in cancer patients treated with immune checkpoint inhibitors (ICIs). This irAE is infrequent, reported to range from 2% to 22.2% of melanoma treated with ICI. In a case of granulomatosis localized in the lung, it is difficult to differentiate g... | 10.14740/jmc4038 | 36,755,995 | Journal of medical cases | 2,023 | ||
Safety and efficacy review of inhaled loxapine for treatment of agitation. | Agitation is common in patients with acute schizophrenia and bipolar disorder, and rapid and effective treatment of acute agitation is an important clinical goal. Loxapine is a first-generation antipsychotic medication available in the United States in oral form for more than three decades. In December 2012, an inhaled... | 10.3371/CSRP.CUWA.032513 | 23,538,290 | D000280:Administration, Inhalation; D014150:Antipsychotic Agents; D001714:Bipolar Disorder; D006801:Humans; D008152:Loxapine; D011595:Psychomotor Agitation; D012559:Schizophrenia; D014481:United States | Clinical schizophrenia & related psychoses | 2,013 | D014150:Antipsychotic Agents; D008152:Loxapine |
Characterization of MC4R Regulation of the Kir7.1 Channel Using the Tl+ Flux Assay. | The family of inward rectifying potassium channels (Kir channels) plays crucial roles in the regulation of heart rhythms, renal excretion, insulin release, and neuronal activity. Their dysfunction has been attributed to numerous diseases such as cardiac arrhythmia, kidney failure and electrolyte imbalance, diabetes mel... | 10.1007/978-1-4939-7362-0_16 | 29,058,194 | D000242:Cyclic AMP; D044385:GTP-Binding Protein alpha Subunits; D005786:Gene Expression Regulation; D057809:HEK293 Cells; D006801:Humans; D018408:Patch-Clamp Techniques; D024661:Potassium Channels, Inwardly Rectifying; D011485:Protein Binding; D044105:Receptor, Melanocortin, Type 4; D015398:Signal Transduction; D013793... | Methods in molecular biology (Clifton, N.J.) | 2,018 | D044385:GTP-Binding Protein alpha Subunits; C000627802:KCNJ13 protein, human; C489477:Kir7.1 channel; C470072:MC4R protein, human; D024661:Potassium Channels, Inwardly Rectifying; D044105:Receptor, Melanocortin, Type 4; D013793:Thallium; D000242:Cyclic AMP |
[Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot]. | In ballistic literature bursting fractures of the skull in gunshot wounds of the head are understood to be produced by the high pressure built up in the cranial cavity as a result of temporary cavity formation. On one hand there is known, that maximum expansion of the temporary cavity does not occur until some time aft... | 2,818,487 | D000328:Adult; D005597:Fractures, Open; D006801:Humans; D006810:Humeral Fractures; D006811:Humerus; D008297:Male; D014948:Wounds, Gunshot | Beitrage zur gerichtlichen Medizin | 1,989 | ||
Redesign of choline acetyltransferase specificity by protein engineering. | Since the development of site-directed mutagenesis techniques over 15 years ago (Zoller, M. J., and Smith, M. (1982) Nucleic Acids Res. 10, 6487-6500), it has been a goal of protein engineering to utilize the procedure to redesign existing enzyme structures to produce proteins with altered or novel catalytic properties... | 10.1074/jbc.273.38.24465 | 9,733,738 | D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D002331:Carnitine; D002333:Carnitine Acyltransferases; D002795:Choline O-Acetyltransferase; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D051381:Rats; D011994:... | The Journal of biological chemistry | 1,998 | D011994:Recombinant Proteins; D002333:Carnitine Acyltransferases; D002795:Choline O-Acetyltransferase; D002331:Carnitine |
Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis. | Mammalian IQGAP1 is considered to modulate organization of the actin cytoskeleton under regulation of signaling proteins Cdc42 or Rac and calmodulin [Bashour et al., 1997: J Cell Biol 137:1555-1566; Hart et al., 1996: EMBO J 15:2997-3005] and also to be involved in cadherin-based cell adhesion [Kuroda et al., 1998: Sci... | 10.1002/cm.10109 | 12,673,597 | D008841:Actin Cytoskeleton; D000818:Animals; D019521:Body Patterning; D002352:Carrier Proteins; D002448:Cell Adhesion; D002462:Cell Membrane; D002465:Cell Movement; D002467:Cell Nucleus; D002478:Cells, Cultured; D018076:DNA, Complementary; D004625:Embryo, Nonmammalian; D005260:Female; D020690:GTPase-Activating Proteins... | Cell motility and the cytoskeleton | 2,003 | D002352:Carrier Proteins; D018076:DNA, Complementary; D020690:GTPase-Activating Proteins; C101203:IQ motif containing GTPase activating protein 1; C484415:IQGAP2 protein, Xenopus; D008840:Microfilament Proteins; D029867:Xenopus Proteins; D020703:ras GTPase-Activating Proteins |
IL-8 derivatives with a reduced potential to form homodimers are fully active in vitro and in vivo. | Interleukin 8 (IL-8) is a member of the CXC subfamily of chemokines which attracts and activates preferentially neutrophilic granulocytes. At nanomolar concentrations monomeric and dimeric forms of the molecule are in equilibrium, with the monomer being the prevalent form. Five amino acids from position 23 to 29 of the... | 10.1006/cyto.1997.0251 | 9,505,139 | D015703:Antigens, CD; D002478:Cells, Cultured; D018932:Chemokine CCL2; D054407:Chemokine CCL4; D019281:Dimerization; D006801:Humans; D016209:Interleukin-8; D019402:Macrophage Inflammatory Proteins; D016296:Mutagenesis; D018123:Receptors, Interleukin; D023062:Receptors, Interleukin-8A | Cytokine | 1,998 | D015703:Antigens, CD; D018932:Chemokine CCL2; D054407:Chemokine CCL4; D016209:Interleukin-8; D019402:Macrophage Inflammatory Proteins; D018123:Receptors, Interleukin; D023062:Receptors, Interleukin-8A |
On the spot: very local chromosomal rearrangements. | Over the last decade, the detection of chromosomal abnormalities has shifted from conventional karyotyping under a light microscope to molecular detection using microarrays. The latter technology identified copy number variation as a major source of variation in the human genome; moreover, copy number variants were fou... | 10.3410/B4-22 | 23,189,093 | F1000 biology reports | 2,012 | ||
Dynamics of TET family expression in porcine preimplantation embryos is related to zygotic genome activation and required for the maintenance of NANOG. | Dynamic changes in DNA methylation are observed during embryo development. Recent studies show that the TET family is involved in these changes by converting 5-methylcytosine (5mec) to 5-hydroxymethylcytosine (5hmec). Specifically, TET3 is responsible for the conversion in the early stages, and then TET1 is a key regul... | 24,315,853 | D000818:Animals; D001755:Blastocyst; D004268:DNA-Binding Proteins; D049308:Dioxygenases; D005306:Fertilization; D005307:Fertilization in Vitro; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D006899:Mixed Function Oxygenases; ... | Developmental biology | 2,014 | D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C486780:NANOG protein, human; D000071317:Nanog Homeobox Protein; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D006899:Mixed Function Oxygenases; C462539:TET1 protein, human; C578792:TET3 protein, human; D049308:Dioxygenases; C541081:TET2 protein, h... | |
Window to His World: Using a Patient's YouTube Channel to Help Diagnose Chronic Mania. | Although chronic mania has been investigated, with several case reports and systematic retrospective cohort studies in the literature, it not a widely recognized entity. No specific definition for chronic mania is provided in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Furthe... | 10.1097/PRA.0000000000000479 | 32,692,130 | D002908:Chronic Disease; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D008297:Male; D000087122:Mania; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D057566:Self Report; D061108:Social Media | Journal of psychiatric practice | 2,020 | |
The metabolic role of PFKFB4 in androgen-independent growth in vitro and PFKFB4 expression in human prostate cancer tissue. | BACKGROUND
It is well known that androgen-deprivation therapy (ADT) can inevitably drive prostate cancer (PCa) cells into a castration-resistant state. According to the "Warburg effect", the metabolism of aggressive tumor cells increases significantly. The growth of cancer cells depends on glycolysis, which may be a po... | 10.1186/s12894-020-00635-0 | 32,487,245 | D049109:Cell Proliferation; D006801:Humans; D008297:Male; D025481:Phosphofructokinase-2; D011471:Prostatic Neoplasms; D014407:Tumor Cells, Cultured | BMC urology | 2,020 | C506672:PFKFB4 protein, human; D025481:Phosphofructokinase-2 |
[Septic shock with acute abdomen in idiopathic hemochromatosis]. | The case of a patient with abdominal crisis and shock without any discernible origin who died 36 hours after hospital admission despite maximal therapy is described. Gram-negative sepsis, peritonitis and haemochromatosis with hepatic siderosis was the post-mortem diagnosis. We consider spontaneous peritonitis arising f... | 10.1055/s-2007-998921 | 8,353,206 | D000006:Abdomen, Acute; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation; D004927:Escherichia coli Infections; D006432:Hemochromatosis; D006801:Humans; D008099:Liver; D008297:Male; D008875:Middle Aged; D009206:Myocardium; D010179:Pancreas; D012772:Shock, Septic | Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS | 1,993 | |
Double duty for CCL21 in dendritic cell trafficking. | Mechanisms controlling leukocyte adhesion, propulsion and directional migration have not been fully integrated. In this issue of Immunity, Schumann et al. (2010) propose that DCs swarm to T cell zones using immobilized CCL21 for adhesive random migration and soluble CCL21 for steering. | 10.1016/j.immuni.2010.05.004 | 20,510,869 | Immunity | 2,010 | ||
The "cytokine profile": a code for sepsis. | Sepsis--the most common cause of death in hospitalized patients--affects over 18 million people worldwide and has an expected 1% increase of incidence per year. Recent clinical trials indicate that therapeutic approaches effective in diseases with similar pathogenesis have a modest effect against sepsis. Although the r... | 10.1016/j.molmed.2004.12.007 | 15,694,867 | D020169:Caspases; D016207:Cytokines; D024243:HMGB1 Protein; D006801:Humans; D018805:Sepsis; D048069:Tumor Necrosis Factors | Trends in molecular medicine | 2,005 | D016207:Cytokines; D024243:HMGB1 Protein; D048069:Tumor Necrosis Factors; D020169:Caspases |
Ideal endotracheal intubation depth at the vocal-cord level to avoid single-lung intubation using the percentage ratio of the tracheal length to body height. | INTRODUCTION
Our previous study revealed racial differences in the tracheal length of cardiac paediatric patients between Germany and Japan. The current study was conducted in two stages, aiming to determine whether the tracheal length differs between cardiac and non-cardiac paediatric patients and whether the results ... | 10.5114/ait.2023.125332 | 37,306,269 | D000328:Adult; D007223:Infant; D007231:Infant, Newborn; D006801:Humans; D002648:Child; D001827:Body Height; D014827:Vocal Cords; D007442:Intubation, Intratracheal; D011184:Postoperative Period | Anaesthesiology intensive therapy | 2,023 | |
Galectin-1 and Galectin-3 Constitute Novel-Binding Partners for Factor VIII. | OBJECTIVE
Recent studies have demonstrated that galectin-1 (Gal-1) and galectin-3 (Gal-3) can bind von Willebrand factor and directly modulate von Willebrand factor-dependent early thrombus formation in vivo. Because the glycans expressed on human factor VIII (FVIII) are similar to those of von Willebrand factor, we in... | 10.1161/ATVBAHA.115.306915 | 27,013,611 | D000818:Animals; D001665:Binding Sites; D001777:Blood Coagulation; D001798:Blood Proteins; D016466:CHO Cells; D003412:Cricetulus; D005169:Factor VIII; D037483:Galectin 1; D037502:Galectin 3; D037161:Galectins; D006031:Glycosylation; D006801:Humans; D010314:Partial Thromboplastin Time; D011485:Protein Binding; D011487:P... | Arteriosclerosis, thrombosis, and vascular biology | 2,016 | D001798:Blood Proteins; D037483:Galectin 1; D037502:Galectin 3; D037161:Galectins; C445499:LGALS1 protein, human; C428445:LGALS3 protein, human; D011994:Recombinant Proteins; C078147:F8 protein, human; D005169:Factor VIII |
Pedicled Rotational Medial and Lateral Gastrocnemius Flaps: Surgical Technique. | Gastrocnemius flaps have been used for decades to reconstruct defects of the proximal tibia and knee. They have proven to be useful in the soft-tissue reconstruction of defects caused by trauma, tumors, and infections about the knee, and the reconstruction of extensor mechanism discontinuity with and without total join... | 10.5435/JAAOS-D-15-00722 | 29,059,111 | D019645:Arthroplasty, Replacement, Knee; D006801:Humans; D007718:Knee Injuries; D018482:Muscle, Skeletal; D019990:Perioperative Care; D011183:Postoperative Complications; D019651:Plastic Surgery Procedures; D017695:Soft Tissue Injuries; D013524:Surgical Flaps | The Journal of the American Academy of Orthopaedic Surgeons | 2,017 | |
Antimicrobial concrete for smart and durable infrastructures: A review. | Concrete structures in sewer systems, marine engineering, underground engineering and other humid environments are easily subjected to microbial attachment, colonization and, eventually, deterioration. With careful selection and treatment, some additives including inorganic and organic antimicrobial agents were found t... | 10.1016/j.conbuildmat.2020.120456 | 32,904,479 | Construction and building materials | 2,020 | ||
Contrasting and cooperative effects of copper and iron deficiencies in male rats fed different concentrations of manganese and different sources of sulfur amino acids in an AIN-93G-based diet. | Dietary nutrient interactions are important factors to consider in the study of nutrient status and requirements. Here, the effects of dietary interactions among copper (Cu), iron (Fe), manganese (Mn) and sulfur amino acids (SAA) on blood cell characteristics and enzyme activities were observed. Male rats (n = 8) were ... | 10.1093/jn/134.2.416 | 14,747,682 | D000603:Amino Acids, Sulfur; D000818:Animals; D003300:Copper; D004032:Diet; D004347:Drug Interactions; D004386:Duodenum; D006454:Hemoglobins; D007501:Iron; D000090463:Iron Deficiencies; D008099:Liver; D008297:Male; D008345:Manganese; D051381:Rats; D017207:Rats, Sprague-Dawley | The Journal of nutrition | 2,004 | D000603:Amino Acids, Sulfur; D006454:Hemoglobins; D008345:Manganese; D003300:Copper; D007501:Iron |
Protective effect of linalool against lipopolysaccharide/D-galactosamine-induced liver injury in mice. | Linalool, a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. The aim of this study was to investigate the effects of linalool against lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced liver injury in mice. Mice were administered with ... | 25,311,666 | D000080462:Acyclic Monoterpenes; D000818:Animals; D000893:Anti-Inflammatory Agents; D056486:Chemical and Drug Induced Liver Injury; D051546:Cyclooxygenase 2; D005688:Galactosamine; D015850:Interleukin-6; D015227:Lipid Peroxidation; D008070:Lipopolysaccharides; D008111:Liver Function Tests; D008297:Male; D008807:Mice, I... | International immunopharmacology | 2,014 | D000080462:Acyclic Monoterpenes; D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D008070:Lipopolysaccharides; D039821:Monoterpenes; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495636:Nfe2l2 protein, mouse; D014409:Tumor Necrosis Factor-alpha; C577686:interleukin-6, mouse; C482199:lipopolysaccharide, E... | |
[The incidence of sudden hearing loss is greater than previously assumed]. | The global incidence of sudden hearing loss is quoted to be 5-20 new cases/100,000 inhabitants/year. In the opinion of the present authors, the data on which these figures are based, are too old, methodologically questionable and non-transferable. An analysis of data from the compulsory health insurance carriers in Bad... | 15,887,682 | D005858:Germany; D003639:Hearing Loss, Sudden; D006801:Humans; D015994:Incidence; D007343:Insurance Carriers; D007348:Insurance, Health; D014012:Tinnitus | MMW Fortschritte der Medizin | 2,005 | ||
A prospective study of behavioral and emotional symptoms in preschoolers. | A substantial number of preschool children exhibit psychological symptoms that have an impact on their own and their families' lives. The aim of the current study was to investigate the prevalence, stability and increase/decrease in emotional and behavioral symptoms and the resultant impairment at two assessment points... | 10.1007/s00787-014-0575-2 | 24,972,693 | D000342:Affective Symptoms; D002648:Child; D002653:Child Behavior Disorders; D002665:Child Psychiatry; D002675:Child, Preschool; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders; D010290:Parents; D015995:Prevalence; D011446:Prospective Studies; D011795:Surveys and Questionnaires | European child & adolescent psychiatry | 2,015 | |
Magnetic reduced graphene oxide loaded hydrogels: Highly versatile and efficient adsorbents for dyes and selective Cr(VI) ions removal. | The formation of composites of reduced graphene oxide (rGO) and magnetic nanoparticles (MP) has flourished in recent years as they combine the advantages of both nanomaterials. Most of these composite materials are prepared by in situ formation of MP onto rGO or by the post-adsorption onto rGO. We report here on a simp... | 10.1016/j.jcis.2017.07.075 | 28,806,655 | Journal of colloid and interface science | 2,017 | ||
Heat shock proteins in hematopoietic malignancies. | Inducible heat shock proteins are molecular chaperones whose expression is increased after many different types of stress. They have a protective function helping the cell to cope with lethal conditions. Their basal expression is low in nonstressed, normal and nontransformed cells. However, in cancer cells and particul... | 10.1016/j.yexcr.2012.05.012 | 22,652,452 | D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D019337:Hematologic Neoplasms; D006801:Humans; D008954:Models, Biolog... | Experimental cell research | 2,012 | D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins |
Children with Obesity and Asthma: Which Are the Best Options for Their Management? | Obesity and asthma are complex disorders related to gene-environment interactions and various lifestyle factors. At present, they represent two of the most significant paediatric health problems worldwide, particularly in industrialized nations. The aim of this narrative review is to evaluate possible therapeutic strat... | 10.3390/nu10111634 | 30,400,197 | D001249:Asthma; D002648:Child; D006801:Humans; D063766:Pediatric Obesity | Nutrients | 2,018 | |
Bath-related thunderclap headache: Case report of a male patient. | Bath-related thunderclap headache (BRTH) is a rare entity, closed to reversible cerebral vasoconstriction syndrome. It is only described in middle-aged women and mainly Asiatic ethnic origins. Role of estrogen is consequently discussed. We report here a case of a 36-year-old man, admitted for five episodes of thundercl... | 10.1111/head.12900 | 27,487,735 | D000328:Adult; D000639:Amitriptyline; D018712:Analgesics, Non-Narcotic; D001494:Baths; D051270:Headache Disorders, Primary; D006801:Humans; D008297:Male | Headache | 2,016 | D018712:Analgesics, Non-Narcotic; D000639:Amitriptyline |
Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture. | The plasminogen activator secreted by a cultured human melanoma cell line was purified and compared with urokinase and with tissue plasminogen activator from human uterus. The purification procedure consisted of chromatography on zinc chelate-agarose, concanavalin A-agarose, and Sephadex G-150 in the presence of 0.01% ... | 6,787,058 | D000596:Amino Acids; D002460:Cell Line; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007700:Kinetics; D008545:Melanoma; D010960:Plasminogen Activators; D014599:Uterus | The Journal of biological chemistry | 1,981 | D000596:Amino Acids; D007106:Immune Sera; D010960:Plasminogen Activators | |
Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer. | Infection-driven inflammation has been implicated in the pathogenesis of ~15-20% of human tumors. Expression of microRNA-155 (miR-155) is elevated during innate immune response and autoimmune disorders as well as in various malignancies. However, the molecular mechanisms providing miR-155 with its oncogenic properties ... | 10.1073/pnas.1101795108 | 21,383,199 | D000964:Antimetabolites, Antineoplastic; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D016147:Genes, Tumor Suppressor; D057809:HEK293 Cells; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase; D007249:Inflammation; D035683:MicroRNAs; D009154:M... | Proceedings of the National Academy of Sciences of the United States of America | 2,011 | D000964:Antimetabolites, Antineoplastic; D018797:Cell Cycle Proteins; C524942:MIRN155 microRNA, human; D035683:MicroRNAs; D009687:Nuclear Proteins; D007041:Hypoxanthine Phosphoribosyltransferase; D011505:Protein-Tyrosine Kinases; C499349:WEE1 protein, human; D013866:Thioguanine |
Structure of TRAF Family: Current Understanding of Receptor Recognition. | Tumor necrosis factor receptor-associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis. Their roles in cellular signaling are mediated mostly by direct interactions with various recep... | 10.3389/fimmu.2018.01999 | 30,214,450 | D020816:Amino Acid Motifs; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D015394:Molecular Structure; D011485:Protein Binding; D011487:Protein Conformation; D000072417:Protein Domains; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D047988:Tumor Necrosis Factor ... | Frontiers in immunology | 2,018 | D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins |
Real-time loop-mediated isothermal amplification: an early-warning tool for quarantine plant pathogen detection. | An effective framework for early warning and rapid response is a crucial element to prevent or mitigate the impact of biological invasions of plant pathogens, especially at ports of entry. Molecular detection of pathogens by using PCR-based methods usually requires a well-equipped laboratory. Rapid detection tools that... | 10.1186/s13568-019-0774-9 | 31,016,406 | AMB Express | 2,019 | ||
Thiol-suppressed I2-etching of AuNRs: acetylcholinesterase-mediated colorimetric detection of organophosphorus pesticides. | For the first time it is demonstrated that sulfhydryl compounds can suppress longitudinal etching of gold nanorods via consuming oxidizers, which provides a new signaling mechanism for colorimetric sensing. As a proof of concept, a colorimetric assay is developed for detecting organophosphorus pesticides, which are mos... | 10.1007/s00604-020-04486-2 | 32,803,418 | D000110:Acetylcholinesterase; D000122:Acetylthiocholine; D002800:Cholinesterase Inhibitors; D003124:Colorimetry; D060766:Drinking Water; D006046:Gold; D007455:Iodine; D060106:Lakes; D057230:Limit of Detection; D043942:Nanotubes; D063086:Organothiophosphates; D010575:Pesticides; D000075082:Proof of Concept Study; D01343... | Mikrochimica acta | 2,020 | D002800:Cholinesterase Inhibitors; D060766:Drinking Water; D063086:Organothiophosphates; D010575:Pesticides; D013438:Sulfhydryl Compounds; D014230:Triazoles; D014874:Water Pollutants, Chemical; C543539:acetylthiocholine iodide; D000122:Acetylthiocholine; C012584:triazophos; D006046:Gold; D007455:Iodine; D000110:Acetylc... |
An epidemiological survey demonstrating decline in reproductive efficiency with age and non-seasonality of reproductive parameters in German shepherd bitches in Kenya. | An epidemiological survey undertaken in Kenya indicated that 2 previously well-established factors, namely decline in reproductive efficiency with age, and non-seasonality of canine reproductive parameters, hold true for German shepherd (GSD) bitches in Kenya. Data collection forms were distributed to randomly selected... | 10.4102/jsava.v73i1.546 | 12,088,072 | D000367:Age Factors; D000375:Aging; D000818:Animals; D001947:Breeding; D004285:Dogs; D005260:Female; D007630:Kenya; D008098:Litter Size; D010298:Parity; D012098:Reproduction; D012621:Seasons | Journal of the South African Veterinary Association | 2,002 | |
Evaluation of the electrostatic field strength at the site of exocytosis in adrenal chromaffin cells. | Exocytosis in secretory cells consists of release from intracellular storage granules directly into the extracellular space via fusion of the granule membrane with the plasma membrane of the cell. It is considered here as comprising two distinct processes. One is the close apposition of granule and plasma membranes. Th... | 10.1016/S0006-3495(98)74043-3 | 9,726,926 | D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002462:Cell Membrane; D019439:Chromaffin Cells; D002837:Chromaffin Granules; D018274:Electroporation; D005089:Exocytosis; D007700:Kinetics; D008051:Lipid Bilayers; D008561:Membrane Fusion; D008954:Models, Biological; D055672:Static Electricity; D01381... | Biophysical journal | 1,998 | D008051:Lipid Bilayers |
Disappearance curves for tumor markers after resection of intrathoracic malignancies. | Determination of the standard elimination kinetics of tumor markers will be helpful in the diagnosis of malignancies. We analyzed the disappearance curves for serum tumor marker levels after resection of intrathoracic malignancies. Serum levels of CEA, SLX, AFP, CA 19-9, SCC, TPA and CYFRA were measured several times a... | 10.1177/172460089901400207 | 10,399,629 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D005260:Female; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; D008297:Male; D0088... | The International journal of biological markers | 1,999 | D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; D009844:Oligosaccharides; D015843:Serpins; D000080506:Sialyl Lewis X Antigen; D019396:Tissue Polypeptide Antigen; C102012:ant... |
Referral and Resource Utilization Among Food Insecure Families Identified in a Pediatric Medical Setting. | OBJECTIVE
Despite increased routine screening for food insecurity (FI) in pediatric medical settings, the uptake of offered food resources after FI identification is not well understood. We aimed to 1) describe utilization of referral and supplemental resources and 2) identify characteristics associated with utilizatio... | 10.1016/j.acap.2020.11.019 | 33,253,935 | D002648:Child; D003120:Colorado; D004636:Emergency Service, Hospital; D000084884:Food Insecurity; D005523:Food Supply; D006801:Humans; D008403:Mass Screening; D012017:Referral and Consultation | Academic pediatrics | 2,021 | |
Evaluation of the intraocular pressure measured with the ocular response analyzer. | PURPOSE
Comparison of the magnitude and repeatability of the intraocular pressure (IOP) measured with the Ocular Response Analyzer (ORA) to that measured with the Goldmann tonometer.
METHODS
Two sets of IOP measurements were made, for 89 eyes of eighty-nine subjects, approximately 1-week apart. Goldmann tonometry was... | 10.3109/02713681003698871 | 20,597,645 | D000328:Adult; D001696:Biomechanical Phenomena; D003315:Cornea; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D011446:Prospective Studies; D015203:Reproducibility of Results; D014065:Tonometry, Ocular; D055815:Young Adult | Current eye research | 2,010 | |
View Point: Disease Modification and Cell Secretome Based Approaches in Parkinson's Disease: Are We on the Right Track? | The term idiopathic Parkinson's disease describes an entity of various not well-characterized disorders resembling each other. They are characterized by chronic neuronal dying originating from various disease mechanisms. They result in the onset of motor and related non-motor features, both of which respond to administ... | 10.2147/BTT.S267281 | 34,349,499 | Biologics : targets & therapy | 2,021 | ||
A Novel Anderson-Evans Polyoxometalate-based Metal-organic Framework Composite for the Highly Selective Isolation and Purification of Cytochrome C from Porcine Heart. | Anderson-Evans type polyoxometalate group (Na6[TeW6O24]·22 H2O, TeW6) was combined with porous metal-organic framework ZIF-8 by electrostatic interaction to obtain a novel Anderson-Evans polyoxometalate-based metal-organic framework composite, TeW6 @ZIF-8. FT-IR, Raman, XRD, TG, DSC, SEM, and TEM were used to character... | 10.1016/j.colsurfb.2022.112420 | 35,227,995 | D000327:Adsorption; D000818:Animals; D000838:Anions; D002853:Chromatography, Liquid; D045304:Cytochromes c; D000073396:Metal-Organic Frameworks; D000071228:Polyelectrolytes; D017550:Spectroscopy, Fourier Transform Infrared; D013552:Swine; D053719:Tandem Mass Spectrometry | Colloids and surfaces. B, Biointerfaces | 2,022 | D000838:Anions; D000073396:Metal-Organic Frameworks; D000071228:Polyelectrolytes; C000712528:polyoxometalate; D045304:Cytochromes c |
COS-triggered oxygen/sulfur exchange of isatins: chemoselective synthesis of functionalized isoindigos and spirothiopyrans via self-condensation and the thio-Diels-Alder reaction. | Herein, we present the first organocatalytic oxygen/sulfur atom exchange reaction (O/S ER) of isatins by employing carbonyl sulfide (COS) as a novel sulfuring reagent under mild reaction conditions. 8-Diazabicyclo[5.4.0]undec-7-ene (DBU) exhibited excellent activity in this approach. Remarkably, the chemical transforma... | 10.1039/d1ob02157e | 34,939,627 | Organic & biomolecular chemistry | 2,022 | ||
A twin registry study of the relationship between posttraumatic stress disorder and nicotine dependence in men. | CONTEXT
Recent studies indicate a strong association between posttraumatic stress disorder (PTSD) and nicotine dependence (ND). However, the explanation for the association remains unclear.
OBJECTIVE
To test competing explanations for the association between PTSD and ND.
DESIGN, SETTING, AND PARTICIPANTS
Analysis o... | 10.1001/archpsyc.62.11.1258 | 16,275,813 | D000328:Adult; D003130:Combat Disorders; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004200:Diseases in Twins; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012042:Registries; ... | Archives of general psychiatry | 2,005 | |
The silent period in pure sensory neuronopathy. | "Normal" electromyographic silent periods (SPs), produced by electrical stimulation of digital nerves, were recorded in the voluntarily contracting abductor pollicis brevis (APB) muscle of a patient with pure sensory neuronopathy and absent sensory nerve action potentials (SNAPs). Such findings implicate the smaller, s... | 10.1002/mus.880151209 | 1,470,199 | D000200:Action Potentials; D000368:Aged; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D006801:Humans; D008475:Median Nerve; D008875:Middle Aged; D009420:Nervous System; D011930:Reaction Time; D012677:Sensation; D012678:Sensation Disorders; D012867:Skin; D014459:Ulnar Nerve | Muscle & nerve | 1,992 | |
Age-specific lipid and lipoprotein thresholds for adolescents. | Plasma lipid and lipoprotein values that are relatively stable in adulthood undergo continuous changes during the developmental years, with most of these changes reflecting natural fluctuations that occur with growth and maturation. Therefore, a clinical classification system appropriate for youth should not consist of... | 10.1097/01.JCN.0000305051.65753.2f | 18,158,509 | D000293:Adolescent; D041923:Adolescent Development; D000328:Adult; D000367:Age Factors; D002318:Cardiovascular Diseases; D002648:Child; D005260:Female; D006801:Humans; D008055:Lipids; D008074:Lipoproteins; D008297:Male; D012015:Reference Standards; D018570:Risk Assessment; D012737:Sex Factors | The Journal of cardiovascular nursing | 2,008 | D008055:Lipids; D008074:Lipoproteins |
Glycoprotein IIb/IIIa Inhibitors in Prevention and Rescue Treatment of Thromboembolic Complications During Endovascular Embolization of Intracranial Aneurysms. | Thromboembolic complications remain a major risk of endovascular neurosurgery during the treatment of intracranial aneurysms, despite the use of therapeutic heparinization and oral antiplatelet therapy when indicated. Glycoprotein (GP) IIb/IIIa inhibitors target a nonredundant pathway of platelet aggregation following ... | 10.1093/neuros/nyx170 | 28,472,526 | D000077284:Abciximab; D000818:Animals; D004621:Embolization, Therapeutic; D057510:Endovascular Procedures; D000077542:Eptifibatide; D006801:Humans; D002532:Intracranial Aneurysm; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D012189:Retrospective Studies; D013923:Thromboembo... | Neurosurgery | 2,018 | D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D000077466:Tirofiban; D000077542:Eptifibatide; D000077284:Abciximab |
Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin. | In the mid- to late 1970s, recombinant deoxyribonucleic acid methods for cloning and expressing genes in E. coli were under intense development. The important question had become: Can humans design and chemically synthesize novel genes that function in bacteria? This question was answered in 1978 and in 1979 with the s... | 10.1210/endrev/bnaa029 | 33,340,315 | D003001:Cloning, Molecular; D004274:DNA, Recombinant; D004926:Escherichia coli; D006801:Humans; D007328:Insulin; D061386:Insulin, Regular, Human | Endocrine reviews | 2,021 | D004274:DNA, Recombinant; D007328:Insulin; D061386:Insulin, Regular, Human |
Coping with anxiety and panic: a factor analytic study. | OBJECTIVES
This study aimed to explore the coping styles that agoraphobia sufferers adopt when attempting to cope with symptoms of anxiety and panic. It aimed to extend Watts's (1989) Coping with Anxiety Questionnaire (CAQ) by including items to assess self-vigilance. It was hypothesized that agoraphobia sufferers woul... | 10.1348/014466599162872 | 10,532,151 | D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000368:Aged; D000379:Agoraphobia; D001007:Anxiety; D001288:Attention; D001294:Attitude to Health; D003430:Cross-Sectional Studies; D004924:Escape Reaction; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007439:Introversion, P... | The British journal of clinical psychology | 1,999 | |
More than the sum of their parts: A dyad-centered approach to understanding adolescent sexual behavior. | Background
Research has documented multiple levels of influences on adolescent sexual behavior, but has generally focused less on the relational nature of this behavior. Studies with dyadic data have provided important findings on relationship process, including the role of gender in different-sex dyads. However, both ... | 10.1007/s13178-020-00528-9 | 35,990,880 | Sexuality research & social policy : journal of NSRC : SR & SP | 2,022 | ||
Increased oxidative and nitrative stress in human stomach associated with cagA+ Helicobacter pylori infection and inflammation. | In order to study the role of Helicobacter pylori infection in gastric carcinogenesis, we have measured oxidized (carbonyls) and nitrated (nitrotyrosine-containing) proteins as markers for oxidative and nitrative stress in 216 human gastric biopsies using dot and western immunoblots and correlated the results with H. p... | 10.1023/a:1010764720524 | 11,330,421 | D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001706:Biopsy; D005753:Gastric Mucosa; D005756:Gastritis; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D016209:Interleukin-8; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D015538:Nitrosation; D018384:Oxid... | Digestive diseases and sciences | 2,001 | D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D016209:Interleukin-8; D012333:RNA, Messenger; C080866:cagA protein, Helicobacter pylori; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II |
Active control of type-I edge-localized modes with n=1 perturbation fields in the JET tokamak. | Type-I edge-localized modes (ELMs) have been mitigated at the JET tokamak using a static external n=1 perturbation field generated by four error field correction coils located far from the plasma. During the application of the n=1 field the ELM frequency increased by a factor of 4 and the amplitude of the D(alpha) sign... | 10.1103/PhysRevLett.98.265004 | 17,678,097 | Physical review letters | 2,007 | ||
The FgSRP1 SR-protein gene is important for plant infection and pre-mRNA processing in Fusarium graminearum. | The versatile functions of SR (serine/arginine-rich) proteins in pre-mRNA splicing and processing are modulated by reversible phosphorylation. Previous studies showed that FgPrp4, the only protein kinase among spliceosome components, is important for intron splicing and the FgSrp1 SR protein is phosphorylated at five c... | 10.1111/1462-2920.13844 | 28,654,215 | D005656:Fungal Proteins; D005670:Fusarium; D005800:Genes, Fungal; D010766:Phosphorylation; D011494:Protein Kinases; D012322:RNA Precursors; D012323:RNA Processing, Post-Transcriptional; D000068103:Serine-Arginine Splicing Factors; D013172:Spores, Fungal; D014255:Trichothecenes; D014908:Triticum | Environmental microbiology | 2,017 | D005656:Fungal Proteins; D012322:RNA Precursors; D014255:Trichothecenes; D000068103:Serine-Arginine Splicing Factors; D011494:Protein Kinases; C007262:deoxynivalenol |
In silico identification of potential protein kinase C alpha inhibitors from phytochemicals from IMPPAT database for anticancer therapeutics: a virtual screening approach. | Protein Kinase C alpha (PKCα) is a critical signaling molecule that plays a crucial role in various physiological processes, including cell growth, differentiation, and survival. Over the years, there has been a growing interest in targeting PKCα as a promising drug target for the treatment of various diseases, includi... | 10.1080/07391102.2023.2252086 | 37,643,015 | Journal of biomolecular structure & dynamics | 2,023 | ||
Cirrhosis as a consequence of graft-versus-host disease. | A 28-yr-old woman with severe idiopathic aplastic anemia received an HLA-identical mixed lymphocyte culture nonreactive bone marrow transplant from her brother. In the months after successful engraftment, she developed cutaneous and hepatic graft-versus-host disease, associated with marked cholestatic jaundice. Despite... | 10.1016/0016-5085(87)90150-8 | 3,539,693 | D000328:Adult; D000741:Anemia, Aplastic; D001706:Biopsy; D016026:Bone Marrow Transplantation; D005260:Female; D006086:Graft vs Host Disease; D006801:Humans; D008099:Liver; D008103:Liver Cirrhosis; D013997:Time Factors | Gastroenterology | 1,987 | |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy. | In patients at risk of developing epilepsy after an initial precipitating injury to the brain, the epileptogenic latent period may offer a window of opportunity for initiating potential antiepileptogenic therapy in an attempt to prevent epilepsy from developing. One potential target for antiepileptogenesis is the devel... | 10.1111/j.1460-9568.2012.08143.x | 22,672,239 | D000818:Animals; D003292:Convulsants; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe; D005260:Female; D058785:GABA-A Receptor Agonists; D007608:Kainic Acid; D008094:Lithium; D010433:Pentylenetetrazole; D010862:Pilocarpine; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A; D012640:S... | The European journal of neuroscience | 2,012 | D003292:Convulsants; D058785:GABA-A Receptor Agonists; D011963:Receptors, GABA-A; D010862:Pilocarpine; D008094:Lithium; D007608:Kainic Acid; D010433:Pentylenetetrazole |
The ater-group of the genus Apanteles Foerster (Hymenoptera, Braconidae, Microgastrinae) from China with the descriptions of forty-eight new species. | The ater-group including subgroup eublemmae of genus Apanteles Foerster from China is revised, in which a total of 97 species are recorded and illustrated. Forty-eight new species are described and illustrated, i.e., A. albummacula Liu Chen, sp. nov.; A. altus Liu Chen, sp. nov.; A. ambultor Liu Chen, sp. nov.; A. amot... | 10.11646/zootaxa.4807.1.1 | 33,056,002 | D000818:Animals; D002681:China; D006927:Hymenoptera | Zootaxa | 2,020 | |
Successful subretinal delivery and monitoring of MicroBeads in mice. | BACKGROUND
To monitor viability of implanted genetically engineered and microencapsulated human stem cells (MicroBeads) in the mouse eye, and to study the impact of the beads and/or xenogenic cells on retinal integrity.
METHODOLOGY/PRINCIPAL FINDINGS
MicroBeads were implanted into the subretinal space of SV126 wild t... | 10.1371/journal.pone.0055173 | 23,383,096 | D000818:Animals; D005123:Eye; D019084:Fluorescent Antibody Technique, Indirect; D049452:Green Fluorescent Proteins; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D018613:Microscopy, Confocal; D008854:Microscopy, Electron; D008863:Microspheres; D009887:Ophthalmoscopy; D012160:Retina; D012162:Retinal Degene... | PloS one | 2,013 | D049452:Green Fluorescent Proteins |
Perfluorohexyloctane in dry eye disease: A systematic review of its efficacy and safety as a novel therapeutic agent. | Perfluorohexyloctane (F6H8), a physically and chemically inert synthetic compound, has recently emerged as a promising candidate for the treatment of DED due to its unique properties. A systematic review that only include full-length randomized controlled studies (RCTs), reporting the effects of F6H8 in three databases... | 10.1016/j.jtos.2023.10.001 | 37,813,152 | The ocular surface | 2,023 | ||
The family's experience of vigilance: challenges for nursing. | The article reports a qualitative study examining vigilance, or the close, protective involvement of families who stay with their hospitalized relatives. Participants described the meanings, patterns, and day-to-day experience of vigilance through five categories of meaning: commitment to care, emotional upheaval, dyna... | 10.1097/00004650-199707000-00009 | 9,274,176 | D001364:Awareness; D015400:Clinical Nursing Research; D005190:Family; D005260:Female; D006760:Hospitalization; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D012931:Social Environment | Holistic nursing practice | 1,997 | |
Clinical Utility of SARS-CoV-2 Antibody Titer Multiplied by Binding Avidity of Receptor-Binding Domain (RBD) in Monitoring Protective Immunity and Clinical Severity. | Conventional serum antibody titer, which expresses antibody level, does not provide antigen binding avidity of the variable region of the antibody, which is essential for the defense response to infection. Here, we quantified anti-SARS-CoV-2 antibody binding avidity to the receptor-binding domain (RBD) by competitive b... | 10.3390/v15081662 | 37,632,005 | D006801:Humans; D000086382:COVID-19; D000086402:SARS-CoV-2; D000914:Antibodies, Viral | Viruses | 2,023 | D000914:Antibodies, Viral |
Killing as means of promoting biodiversity. | Bacteriocins are usually viewed as the effective weapons of bacterial killers. However, killing competitors with bacteriocins may be not only a means of eliminating other strains, but also a crucial unappreciated mechanism promoting bacterial diversity. In the present short review, we summarize recent empirical and the... | 10.1042/BST20120196 | 23,176,508 | D000220:Adaptation, Biological; D000898:Antibiosis; D001430:Bacteriocins; D044822:Biodiversity; D019143:Evolution, Molecular; D006090:Gram-Negative Bacteria; D006094:Gram-Positive Bacteria; D006801:Humans; D054892:Metagenome; D008954:Models, Biological | Biochemical Society transactions | 2,012 | D001430:Bacteriocins |
[Results of combined surgical and radiotherapeutic treatment of the carcinoma of the urinary bladder of stage P2/P3]. | The authors studied the survival rates of the P2 and P3 patients within a group of 287 patients suffering from carcinomas of the urinary bladder who had been treated by urologic operation and radiotherapy. A differentiation was made between the surgical methods transurethral resection (TUR), bladder wall resection and ... | 7,147,274 | D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D011182:Postoperative Care; D013534:Survival; D001749:Urinary Bladder Neoplasms | Strahlentherapie | 1,982 | ||
Interaction of G protein Gbetagamma dimers with small GTP-binding proteins of the Rho family. | Gbetagamma dimers of heterotrimeric G proteins have been shown to be important for the translocation of cytosolic proteins to membranes. The involvement of Gbetagamma in those signaling processes mediated by small GTP-binding proteins of the Rho family was studied using purified proteins. We showed specific binding of ... | 10.1016/s0014-5793(96)01327-0 | 8,985,147 | D000818:Animals; D001704:Biopolymers; D002417:Cattle; D019204:GTP-Binding Proteins; D006150:Guanine Nucleotides; D011485:Protein Binding; D015398:Signal Transduction | FEBS letters | 1,996 | D001704:Biopolymers; D006150:Guanine Nucleotides; D019204:GTP-Binding Proteins |
A tumor-suppressing function in the epithelial adhesion protein Trask. | Trask/CDCP1 is a transmembrane glycoprotein widely expressed in epithelial tissues whose functions are just beginning to be understood, but include a role as an anti-adhesive effector of Src kinases. Early studies looking at RNA transcript levels seemed to suggest overexpression in some cancers, but immunostaining stud... | 10.1038/onc.2011.246 | 21,706,059 | D000818:Animals; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D045744:Cell Line, Tumor; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D008562:Membrane Glycoproteins; D051379:Mice; D041681:NIH 3T3 Cells; D009363:Neoplasm Proteins; D010766:Phosphorylation; D025521:... | Oncogene | 2,012 | D015703:Antigens, CD; D000951:Antigens, Neoplasm; C432044:CDCP1 protein, human; C529673:CDCP1 protein, mouse; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D051416:Focal Adhesion Protein-Tyrosine Kinases |
APOK3, a pollen killer antidote in Arabidopsis thaliana. | The principles of heredity state that the two alleles carried by a heterozygote are equally transmitted to the progeny. However, genomic regions that escape this rule have been reported in many organisms. It is notably the case of genetic loci referred to as gamete killers, where one allele enhances its transmission by... | 10.1093/genetics/iyac089 | 35,666,201 | D000483:Alleles; D000931:Antidotes; D017360:Arabidopsis; D011042:Poisons; D011058:Pollen | Genetics | 2,022 | D000931:Antidotes; D011042:Poisons |
Cell-mediated cytotoxicity against virus-infected target cells in humans. I. Characterization of the effector lymphocyte. | In a 51Chromium release assay performed without immune sera, purified lymphocytes from randomly selected healthy donors killed significantly more allogeneic virus-infected than noninfected fibroblasts. An incubation period of 18 to 20 hr was optimal for determining cytotoxicity, but increased cytotoxic activity against... | 681,748 | D000328:Adult; D000914:Antibodies, Viral; D002469:Cell Separation; D003602:Cytotoxicity, Immunologic; D006561:Herpes Simplex; D006801:Humans; D007111:Immunity, Cellular; D009980:Influenza A virus; D008214:Lymphocytes; D008459:Measles virus; D009109:Mumps virus; D014777:Virus Diseases | Journal of immunology (Baltimore, Md. : 1950) | 1,978 | D000914:Antibodies, Viral | |
Effects of moderating variables on product managers' behavior. | This study examined the moderating effects of role autonomy, need for affiliation, and tolerance of ambiguity on the relationships between role pressures of conflict and ambiguity and personal outcomes of job satisfaction, job-related tension, and perceived performance. Data from 166 product managers indicate that role... | 10.2466/pr0.1990.66.1.295 | 2,326,419 | D000328:Adult; D003258:Consumer Behavior; D005260:Female; D006801:Humans; D007588:Job Satisfaction; D008297:Male; D009934:Organization and Administration; D009935:Organizational Affiliation; D015279:Organizational Culture; D012380:Role | Psychological reports | 1,990 | |
Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor. | Signaling mechanisms leading to regulation of gene transcription by growth hormone (GH) and other molecules that signal via the cytokine receptor family have been elusive. Based upon recent findings that GH and interferons activate JAK family tyrosine kinases, we have identified a novel signaling pathway leading from t... | 7,508,925 | D016475:3T3 Cells; D000818:Animals; D004268:DNA-Binding Proteins; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts; D013006:Growth Hormone; D006801:Humans; D007371:Interferon-gamma; D051379:Mice; D008970:Molecular Weight; D010766:Phosphorylation; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases... | The Journal of biological chemistry | 1,994 | D004268:DNA-Binding Proteins; D011994:Recombinant Proteins; D014157:Transcription Factors; D019000:Phosphotyrosine; D014443:Tyrosine; D007371:Interferon-gamma; D013006:Growth Hormone; D011505:Protein-Tyrosine Kinases | |
Inhibitory effect of cold stress against acetaminophen-induced hepatic injury in B6C3F1 and ICR mice. | The effect of cold stress (at 0 +/- 1 degree C for 3 h) on acetaminophen-induced hepatic injury was investigated in B6C3F1 and ICR mice. When acetaminophen (250 mg/kg) was injected intraperitoneally in B6C3F1 mice, the plasma GPT activity was significantly increased by 93 or 107-fold at 6 h or 24 h after the drug injec... | 10.1016/0378-4274(95)03424-2 | 8,553,366 | D000082:Acetaminophen; D000410:Alanine Transaminase; D000818:Animals; D001831:Body Temperature; D056486:Chemical and Drug Induced Liver Injury; D003080:Cold Temperature; D005978:Glutathione; D008099:Liver; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013312:Stress, Physiological; D013997:Time Factors | Toxicology letters | 1,995 | D000082:Acetaminophen; D000410:Alanine Transaminase; D005978:Glutathione |
Bioinformatic tools for inferring functional information from plant microarray data II: Analysis beyond single gene. | While it is possible to interpret microarray experiments a single gene at a time, most studies generate long lists of differentially expressed genes whose interpretation requires the integration of prior biological knowledge. This prior knowledge is stored in various public and private databases and covers several aspe... | 10.1155/2008/893941 | 18,615,189 | International journal of plant genomics | 2,008 | ||
Results of intraoperative electron beam radiotherapy containing multimodality treatment for locally unresectable T4 rectal cancer: a pooled analysis of the Mayo Clinic Rochester and Catharina Hospital Eindhoven. | BACKGROUND
The aim of this study is to analyse the pooled results of intraoperative electron beam radiotherapy (IOERT) containing multimodality treatment of locally advanced T4 rectal cancer, initially unresectable for cure, from the Mayo Clinic, Rochester, USA (MCR) and Catharina Hospital, Eindhoven, The Netherlands (... | 10.21037/jgo.2016.07.01 | 28,078,113 | Journal of gastrointestinal oncology | 2,016 | ||
Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication. | Hepatitis C virus (HCV) infection is a major cause of human chronic liver disease and hepatocellular carcinoma. G-quadruplex (G4) is an important four-stranded secondary structure of nucleic acids. Recently, we discovered that the core gene of HCV contains a G4 RNA structure; however, the interaction between the HCV co... | 10.1093/nar/gky1177 | 30,462,330 | D054856:G-Quadruplexes; D015967:Gene Expression Regulation, Viral; D016174:Hepacivirus; D006526:Hepatitis C; D006801:Humans; D010750:Phosphoproteins; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins; D014779:Virus Replication; D000097796:Nucleolin | Nucleic acids research | 2,019 | D010750:Phosphoproteins; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins |
Photocatalytic Difunctionalization of Vinyl Ureas by Radical Addition Polar Truce-Smiles Rearrangement Cascades. | We report tandem alkyl-arylations and phosphonyl-arylations of vinyl ureas by way of a photocatalytic radical-polar crossover mechanism. Addition of photoredox-generated radicals to the alkene forms a new C-C or C-P bond and generates a product radical adjacent to the urea function. Reductive termination of the photoca... | 10.1002/anie.202003632 | 32,227,575 | Angewandte Chemie (International ed. in English) | 2,020 | ||
A possible relationship between Beckwith-Wiedemann syndrome and prune belly syndrome. | A new case of the association of the Beckwith-Wiedemann and prune belly syndrome is reported and the aetiology of the syndromes discussed. | 10.1097/00019605-200210000-00012 | 12,401,997 | D001506:Beckwith-Wiedemann Syndrome; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011535:Prune Belly Syndrome | Clinical dysmorphology | 2,002 | |
Ultrasmall superparamagnetic iron oxide (USPIO)-based liposomes as magnetic resonance imaging probes. | BACKGROUND
Magnetic liposomes (MLs) are phospholipid vesicles that encapsulate magnetic and/or paramagnetic nanoparticles. They are applied as contrast agents for magnetic resonance imaging (MRI). MLs have an advantage over free magnetic nanocores, in that various functional groups can be attached to the surface of lip... | 10.2147/IJN.S30617 | 22,661,890 | D000818:Animals; D003124:Colorimetry; D003287:Contrast Media; D005260:Female; D005454:Fluorescence Polarization; D008081:Liposomes; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D008297:Male; D051379:Mice; D010316:Particle Size; D019047:Phantoms, Imaging; D014018:Tissue Distribution | International journal of nanomedicine | 2,012 | D003287:Contrast Media; D008081:Liposomes; D058185:Magnetite Nanoparticles |
Combined Corneal Cross-Linking and Myoring Implantation in Advanced Keratoconus: Femtosecond Laser versus Manual Dissection. | BACKGROUND
Intrastromal corneal ring segments are widely adopted for keratoconus management. However, the complete ring (Myoring) was proposed to be superior in advanced cases. Myoring can be implanted either via femtoassisted or manual dissection techniques. A comparison between both techniques can delineate any diffe... | 10.1155/2021/6673842 | 34,513,086 | Journal of ophthalmology | 2,021 | ||
Influence of Different Percentages of Binders on the Physico-Mechanical Properties of Rhizophora spp. Particleboard as Natural-Based Tissue-Equivalent Phantom for Radiation Dosimetry Applications. | Rhizophora spp. particleboard with the incorporation of lignin and soy flour as binders were fabricated and the influence of different percentages of lignin and soy flour (0%, 6% and 12%) on the physico-mechanical properties of the particleboard were studied. The samples were characterised by Fourier transform infrared... | 10.3390/polym13111868 | 34,199,810 | Polymers | 2,021 | ||
Processing and characterization of absorbable polylactide polymers for use in surgical implants. | Absorbable fibers of linear poly-alpha-hydroxy acids have been used successfully in providing temporary scaffolds for tissue regeneration. In some surgical applications, degradation rates for poly(glycolide) (PGA) are too high, but implants of poly(L-lactide) (PLLA) fibers may degrade too slowly for optimal function. ... | 10.1002/jab.770050206 | 10,172,072 | D001672:Biocompatible Materials; D001718:Birefringence; D002152:Calorimetry, Differential Scanning; D004548:Elasticity; D006801:Humans; D008422:Materials Testing; D008970:Molecular Weight; D011091:Polyesters; D019736:Prostheses and Implants; D013314:Stress, Mechanical; D013718:Tensile Strength; D017155:Wettability; D01... | Journal of applied biomaterials : an official journal of the Society for Biomaterials | 1,994 | D001672:Biocompatible Materials; D011091:Polyesters |
Improved PCR-Based Detection of Soil Transmitted Helminth Infections Using a Next-Generation Sequencing Approach to Assay Design. | BACKGROUND
The soil transmitted helminths are a group of parasitic worms responsible for extensive morbidity in many of the world's most economically depressed locations. With growing emphasis on disease mapping and eradication, the availability of accurate and cost-effective diagnostic measures is of paramount importa... | 10.1371/journal.pntd.0004578 | 27,027,771 | D000818:Animals; D018509:DNA, Helminth; D006373:Helminthiasis; D006801:Humans; D016133:Polymerase Chain Reaction; D012987:Soil | PLoS neglected tropical diseases | 2,016 | D018509:DNA, Helminth; D012987:Soil |
VEGF Detection via Impedance Spectroscopy on Surface Functionalized Interdigitated Biosensor. | Vascular endothelial growth factor (VEGF), a clinically important biomarker, often plays a key role in angiogenesis, would healing, tumor growth, lung development, and in retinal diseases. Hence, detecting and quantifying VEGF is deemed medically important in clinical diagnosis for many diseases. In this report, a simp... | 10.3390/jfb14070365 | 37,504,860 | Journal of functional biomaterials | 2,023 | ||
An In-vitro Evaluation of Retention Force of All PEEK, All Zirconia and Zirconia-PEEK Telescopic Attachment for Mandibular Overdentures. | The objective of this study is to compare retention capacity of mandibular implant-supported overdenture with all zirconia, zirconia-PEEK, and all PEEK telescopic attachments. Sixty acrylic resin models of mandible were used. Telescopic attachment system was made up of all zirconia, all PEEK, and zirconia-PEEK. Evaluat... | 10.4103/jpbs.jpbs_54_23 | 37,694,001 | Journal of pharmacy & bioallied sciences | 2,023 | ||
MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties. | We observe that one of the high molecular mass microtubule-associated proteins (MAPs) from brain exhibits nucleotide-dependent binding to microtubules. We identify the protein as MAP IC, which was previously described in this laboratory as a minor component of standard microtubule preparations (Bloom, G.S., T. Schoenfe... | 10.1083/jcb.105.3.1273 | 2,958,482 | D000251:Adenosine Triphosphatases; D000255:Adenosine Triphosphate; D000818:Animals; D001921:Brain; D002417:Cattle; D004398:Dyneins; D046911:Macromolecular Substances; D008869:Microtubule-Associated Proteins; D008870:Microtubules; D008970:Molecular Weight; D011485:Protein Binding | The Journal of cell biology | 1,987 | D046911:Macromolecular Substances; D008869:Microtubule-Associated Proteins; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D004398:Dyneins |
Basal ganglia cerebral blood flow associates with psychomotor speed in adults with type 1 diabetes. | Type 1 diabetes is associated with slower psychomotor speed, but the neural basis of this relationship is not yet understood. The basal ganglia are a set of structures that are vulnerable to small vessel disease, particularly in individuals with type 1 diabetes. Thus, we examined the relationship between psychomotor sp... | 10.1007/s11682-017-9783-y | 29,164,504 | D000328:Adult; D001479:Basal Ganglia; D002560:Cerebrovascular Circulation; D003922:Diabetes Mellitus, Type 1; D005260:Female; D005500:Follow-Up Studies; D066128:Gray Matter; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009929:Organ Size; D0115... | Brain imaging and behavior | 2,018 | |
Identification of alternative products and optimization of 2-nitro-5-thiocyanatobenzoic acid cyanylation and cleavage at cysteine residues. | The reagent 2-nitro-5-thiocyanatobenzoic acid (NTCB) is commonly used to cyanylate and cleave proteins at cysteine residues, but this two-step reaction requires lengthy incubations and produces highly incomplete cleavages. In previous reports, incomplete cleavage was attributed to a competing beta-elimination reaction ... | 10.1016/j.ab.2004.08.008 | 15,464,952 | D003545:Cysteine; D009570:Nitriles; D009842:Oligopeptides; D013861:Thiocyanates | Analytical biochemistry | 2,004 | D009570:Nitriles; D009842:Oligopeptides; D013861:Thiocyanates; D003545:Cysteine; C008658:2-nitro-5-thiocyanobenzoic acid |
Twenty-years of lung transplantation in Taiwan: Effects of cumulative institutional experience on early outcomes. | BACKGROUND/PURPOSE
Lung transplantation in Taiwan began in 1991, but the experience was limited and diverse in the early years. We examined the cumulative institutional experience of the largest lung transplant cohort in Taiwan.
METHODS
A retrospective review of lung transplantations performed at a single institution... | 10.1016/j.jfma.2017.08.011 | 28,958,705 | D000328:Adult; D002315:Cardiopulmonary Bypass; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012121:Respiration, Artificial; D012189:Retrospective Studies;... | Journal of the Formosan Medical Association = Taiwan yi zhi | 2,017 | |
Comparing neonatal respiratory morbidity in neonates delivered after 34 weeks of gestation with and without antenatal corticosteroid. | OBJECTIVE
To investigate the effect of antenatal corticosteroid prophylaxis on neonatal respiratory morbidity between 34 and 37 weeks of gestation.
METHODS
This retrospective study evaluated the neonatal respiratory complications of 683 low risk singleton pregnancies delivered at 34-37 weeks of gestation in a tertiar... | 10.12669/pjms.336.14031 | 29,492,065 | Pakistan journal of medical sciences | 2,017 | ||
Thyroid nodules treated with percutaneous radiofrequency thermal ablation: a comparative study. | PURPOSE
Percutaneous radiofrequency thermal ablation (RTA) was reported as an effective tool for the management of thyroid nodules (TNs). The aim of this study was to investigate the effects of RTA and to establish whether they were treatment-related by comparison with a matched, untreated control group.
PATIENTS AND... | 10.1210/jc.2012-2251 | 23,019,349 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D013956:Antithyroid Agents; D044963:Biopsy, Fine-Needle; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008713:Methimazole; D008875:Middle Aged; D016606:Thyroid Nodule; D0... | The Journal of clinical endocrinology and metabolism | 2,012 | D013956:Antithyroid Agents; D008713:Methimazole |
Investigating a novel fMRI cannabis cue reactivity task in youth. | OBJECTIVE
Adult and adolescent studies suggest increased motivational responses to cannabis cues among regular cannabis users. However, functional magnetic resonance imaging (fMRI) studies have not explored neural activation in response to visual cannabis cues among adolescents in the United States. Gaining a better un... | 10.1016/j.addbeh.2018.09.015 | 30,243,035 | D000293:Adolescent; D000328:Adult; D001921:Brain; D003463:Cues; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D002189:Marijuana Abuse; D009042:Motivation; D055815:Young Adult | Addictive behaviors | 2,019 | |
Considerations in the identification of functional RNA structural elements in genomic alignments. | BACKGROUND
Accurate identification of novel, functional noncoding (nc) RNA features in genome sequence has proven more difficult than for exons. Current algorithms identify and score potential RNA secondary structures on the basis of thermodynamic stability, conservation, and/or covariance in sequence alignments. Neith... | 10.1186/1471-2105-8-33 | 17,263,882 | D000465:Algorithms; D001483:Base Sequence; D002874:Chromosome Mapping; D017124:Conserved Sequence; D008969:Molecular Sequence Data; D012313:RNA; D016415:Sequence Alignment; D017423:Sequence Analysis, RNA | BMC bioinformatics | 2,007 | D012313:RNA |
Changing patterns of diabetic deaths in youth and young adults by gender in the major developed countries 1974-97. | UNLABELLED
The objective was to examine any changes in "Diabetic Deaths" in major developed countries 1974-97 and to determine whether youth (aged 15-24 years) and young adult (aged 25-44 years) males are at greater risk of Diabetic Death (DD) than women by comparing DD with "All Cause Deaths" (ACD) by gender.
DESIGN... | 10.1515/ijamh.2003.15.2.169 | 12,955,820 | D000293:Adolescent; D000328:Adult; D002423:Cause of Death; D019049:Developed Countries; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D008137:Longitudinal Studies; D008297:Male; D010349:Patient Compliance; D018570:Risk Assessment; D012648:Self Care; D012737... | International journal of adolescent medicine and health | 2,003 | |
[Duchenne-type muscular dystrophy: problems, early diagnosis, early treatment (author's transl)]. | The aetiology and pathogenesis of the Duchenne-type muscular dystrophy (pseudohypertrophic muscular dystrophy) are still largely unknown. The possibilities of treating the disease are rather limited. Treatment is the more successful, the earlier diagnosis was possible, and the earlier treatment is initiated. The CK-Scr... | 362,050 | D064987:Cell- and Tissue-Based Therapy; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase; D005817:Genetic Counseling; D006579:Heterozygote; D006801:Humans; D007360:Intelligence; D008297:Male; D009136:Muscular Dystrophies; D026741:Physical Therapy Modalities; D013997:Time Factors | Klinische Padiatrie | 1,978 | D003402:Creatine Kinase | |
Temporal events regulating the early phases of the mammalian cell cycle. | It is proposed that the regulation of the pathways directing mammalian cell cycle progression involves several oncogenes. A summary of what is known about some of these regulatory oncogenes (fos, jun, myc, and Rb-1) and where they might function in the progression of a cell from G0 to G1 and G1 to S is presented. Data ... | 10.1016/0955-0674(91)90150-w | 1,883,619 | D000818:Animals; D001483:Base Sequence; D002453:Cell Cycle; D004247:DNA; D016193:G1 Phase; D005786:Gene Expression Regulation; D006657:Histones; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes; D016196:S Phase; D013937:Thymidine Kinase | Current opinion in cell biology | 1,991 | D006657:Histones; D004247:DNA; D013937:Thymidine Kinase |
Simultaneous Cortical Surface Labeling and Sulcal Curve Extraction. | Automatic labeling of the gyri and sulci on the cortical surface is important for studying cortical morphology and brain functions within populations. A method to simultaneously label gyral regions and extract sulcal curves is proposed. Assuming that the gyral regions parcellate the whole cortical surface into contiguo... | 27,471,339 | Proceedings of SPIE--the International Society for Optical Engineering | 2,012 | |||
An environmental bacterial taxon with a large and distinct metabolic repertoire. | Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such 'talented' producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic diversity. The uncultured majority is generally perceived as a large, untapped resource of ... | 10.1038/nature12959 | 24,476,823 | D000818:Animals; D053898:Biosynthetic Pathways; D020564:Deltaproteobacteria; D055808:Drug Discovery; D004783:Environmental Microbiology; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D056186:Metagenomics; D008969:Molecular Sequence Data; D005810:Multigene Family; D010455:Peptides; D061065:Polyketides; D011161:Po... | Nature | 2,014 | D010455:Peptides; D061065:Polyketides |
Inflammatory bowel disease and anxiety: links, risks, and challenges faced. | Inflammatory bowel disease (IBD) causes severe physical symptoms and is also associated with psychological comorbidities. Abnormal anxiety levels are found in up to 40% of patients with IBD. Anxiety symptoms are often related to flares of IBD but may persist in times of remission. Detection of anxiety disorder (AD) in ... | 10.2147/CEG.S57982 | 25,848,313 | Clinical and experimental gastroenterology | 2,015 | ||
An Onyx tunnel: reconstructive transvenous balloon-assisted Onyx embolization for dural arteriovenous fistula of the transverse-sigmoid sinus. | Transvenous embolization is an effective method for treating dural arteriovenous fistulas (DAVFs) of the transverse-sigmoid sinus (TSS). However, in cases of complicated DAVFs, it is difficult to preserve the patency of the dural sinus. The authors describe the technical details of a new reconstructive technique using ... | 29,148,903 | D000368:Aged; D000800:Angioplasty, Balloon; D020785:Central Nervous System Vascular Malformations; D003392:Cranial Sinuses; D004121:Dimethyl Sulfoxide; D004621:Embolization, Therapeutic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors... | Journal of neurosurgery | 2,018 | C450660:Onyx copolymer; D010975:Platelet Aggregation Inhibitors; D011145:Polyvinyls; D004121:Dimethyl Sulfoxide | |
Ciprofloxacin absorption is impaired in patients given enteral feedings orally and via gastrostomy and jejunostomy tubes. | Twenty-six hospitalized patients participated in a randomized crossover study to evaluate the effect of enteral feedings on ciprofloxacin absorption when given orally or via gastrostomy or jejunostomy tubes. Patients in the oral group received an intact 500-mg ciprofloxacin tablet alone or ciprofloxacin plus three oral... | 10.1128/AAC.40.1.6 | 8,787,869 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents; D001682:Biological Availability; D002939:Ciprofloxacin; D018592:Cross-Over Studies; D004750:Enteral Nutrition; D005260:Female; D005774:Gastrostomy; D006801:Humans; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; ... | Antimicrobial agents and chemotherapy | 1,996 | D000890:Anti-Infective Agents; D002939:Ciprofloxacin |
Role of oil extract of garlic (Allium sativum Linn.) on intestinal transference of calcium and its possible correlation with preservation of skeletal health in an ovariectomized rat model of osteoporosis. | The present study was undertaken to examine the effects of an oil extract of garlic on the in vivo intestinal transference of calcium, and also to verify its role in maintaining the bone mineral content and bone tensile strength in an ovariectomized rat model of osteoporosis. The results suggest that, in this experimen... | 10.1002/ptr.1888 | 16,619,371 | D000469:Alkaline Phosphatase; D000818:Animals; D015519:Bone Density; D000252:Calcium-Transporting ATPases; D004195:Disease Models, Animal; D004958:Estradiol; D005260:Female; D005737:Garlic; D006801:Humans; D007413:Intestinal Mucosa; D015663:Osteoporosis, Postmenopausal; D010052:Ovariectomy; D010281:Parathyroid Hormone;... | Phytotherapy research : PTR | 2,006 | D010281:Parathyroid Hormone; D010938:Plant Oils; D004958:Estradiol; D000469:Alkaline Phosphatase; D000252:Calcium-Transporting ATPases |
Atopic dermatitis: Tofacitinib, an option for refractory disease. | Atopic dermatitis (AD) is a common skin disease, associated with high burden impact in quality of live, in moderate-severe disease severity. Several targeted drugs are under development for AD. Here, we present a patient with refractory disease to systemic traditional immunosuppressive drugs, treated successfully with ... | 10.1002/ccr3.3325 | 33,363,913 | Clinical case reports | 2,020 |
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