title large_stringlengths 0 979 | abstract large_stringlengths 1 94.7k | doi large_stringlengths 0 71 | pmid int64 21 38.1M | mesh_terms large_stringlengths 0 1.47k | journal large_stringlengths 1 239 | pubdate int16 1.97k 2.02k | chemical_list large_stringlengths 0 1.47k |
|---|---|---|---|---|---|---|---|
QSAR modeling with the electrotopological state: TIBO derivatives. | Quantitative structure-activity relationships (QSAR), based on the atom level E-state indices and calculated molecular properties (log P, MR), have been developed for the affinity of a large set of TIBO derivatives against HIV-1 reverse transcriptase (HIV-1 RT) utilizing multiple linear regression techniques. A model w... | 10.1021/ci0001435 | 11,277,732 | D001569:Benzodiazepines; D016208:Databases, Factual; D004563:Electrochemistry; D054303:HIV Reverse Transcriptase; D006801:Humans; D007093:Imidazoles; D008956:Models, Chemical; D021281:Quantitative Structure-Activity Relationship; D012044:Regression Analysis; D018894:Reverse Transcriptase Inhibitors | Journal of chemical information and computer sciences | 2,001 | C097516:8-chlorotetrahydroimidazo(4,5,1-jk)(1,4)-benzodiazepin-2(1H)-thione; D007093:Imidazoles; D018894:Reverse Transcriptase Inhibitors; D001569:Benzodiazepines; C092133:R 79882; D054303:HIV Reverse Transcriptase |
Associations of WHO/UNICEF Joint Monitoring Program (JMP) Water, Sanitation and Hygiene (WASH) Service Ladder service levels and sociodemographic factors with diarrhoeal disease among children under 5 years in Bishoftu town, Ethiopia: a cross-sectional study. | OBJECTIVE
To determine the associations of WHO/UNICEF Joint Monitoring Program Water, Sanitation and Hygiene (WASH) Service Ladder service levels and sociodemographic factors with diarrhoeal disease among children under 5 years in Bishoftu town, Ethiopia.
DESIGN
A community-based cross-sectional study.
SETTING
Bish... | 10.1136/bmjopen-2022-071296 | 37,500,269 | D005260:Female; D006801:Humans; D002648:Child; D002675:Child, Preschool; D060766:Drinking Water; D005002:Ethiopia; D003430:Cross-Sectional Studies; D014881:Water Supply; D012499:Sanitation; D000091569:Sociodemographic Factors; D003967:Diarrhea; D014480:United Nations; D011795:Surveys and Questionnaires; D014944:World H... | BMJ open | 2,023 | D060766:Drinking Water |
Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy. | PROteolysis TArgeting Chimeras (PROTACs) has been exploited to degrade putative protein targets. However, the antitumor performance of PROTACs is impaired by their insufficient tumour distribution. Herein, we present de novo designed polymeric PROTAC (POLY-PROTAC) nanotherapeutics for tumour-specific protein degradatio... | 10.1038/s41467-022-32050-4 | 35,882,867 | D000818:Animals; D006801:Humans; D051379:Mice; D018797:Cell Cycle Proteins; D020778:Matrix Metalloproteinase 2; D053758:Nanoparticles; D009369:Neoplasms; D009687:Nuclear Proteins; D059748:Proteolysis; D014157:Transcription Factors; D059016:Tumor Microenvironment | Nature communications | 2,022 | C441289:BRD4 protein, human; D018797:Cell Cycle Proteins; D020778:Matrix Metalloproteinase 2; D009687:Nuclear Proteins; D014157:Transcription Factors |
The appearance of the equine metacarpophalangeal region on high-field vs. standing low-field magnetic resonance imaging. | The appearance of the equine metacarpophalangeal (MCP) joint on high-field (1.5 T) vs. low-field standing (0.27 T) magnetic resonance (MR) images was evaluated. Objectives were (1) to describe the MR appearance of anatomic structures of clinical interest on images of the equine MCP joint obtained from 20 equine cadaver... | 21,322,388 | D000818:Animals; D002102:Cadaver; D005260:Female; D005552:Forelimb; D006736:Horses; D008279:Magnetic Resonance Imaging; D008297:Male; D015203:Reproducibility of Results | Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association | 2,011 | ||
Upfront DPYD Genotype-Guided Treatment for Fluoropyrimidine-Based Chemotherapy in Advanced and Metastatic Colorectal Cancer: A Cost-Effectiveness Analysis. | OBJECTIVES
Fluoropyrimidines are the most widely used chemotherapy drugs for advanced and metastatic colorectal cancer (CRC). Individuals with certain DPYD gene variants are exposed to an increased risk of severe fluoropyrimidine-related toxicities. This study aimed to evaluate the cost-effectiveness of preemptive DPYD... | 10.1016/j.vhri.2023.04.004 | 37,329,861 | D006801:Humans; D000094703:Cost-Effectiveness Analysis; D007492:Iran; D042943:Dihydrouracil Dehydrogenase (NADP); D005838:Genotype; D015179:Colorectal Neoplasms | Value in health regional issues | 2,023 | D042943:Dihydrouracil Dehydrogenase (NADP) |
Syntheses, crystal structures, and luminescent properties of novel layered lanthanide sulfonate-phosphonates. | Hydrothermal reactions of lanthanide metal salts with MeN(CH(2)CO(2)H)(CH(2)PO(3)H(2)) (H(3)L) and 5-sulfoisophthalic acid monosodium salt (NaH(2)BTS) lead to four isomorphous lanthanide carboxylate-phosphonate-sulfonate hybrids, namely, Ln(H(2)L)(HBTS)(H(2)O)(2).H(2)O (Ln = La (1), Pr (2), Nd (3), Gd (4)). Their struc... | 10.1021/ic049376u | 15,332,814 | D000476:Alkanesulfonates; D018360:Crystallography, X-Ray; D028581:Lanthanoid Series Elements; D008163:Luminescent Measurements; D008956:Models, Chemical; D008958:Models, Molecular; D009942:Organometallic Compounds; D063065:Organophosphonates; D013457:Sulfur Compounds | Inorganic chemistry | 2,004 | D000476:Alkanesulfonates; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D063065:Organophosphonates; D013457:Sulfur Compounds |
Incorporating the service accomplishments into pre-registration curriculum to enhance reflective practice. | Much emphasis is being placed on the importance of reflective practice as a means to ensure that practitioners are competent in their practice. It is therefore important to ensure that student nurses acquire these reflective skills as part of their development throughout pre-registration curricula. Although reflective ... | 10.1016/s0260-6917(98)80007-5 | 9,887,756 | D000368:Aged; D003479:Curriculum; D004508:Education, Nursing, Baccalaureate; D006801:Humans; D008297:Male; D008875:Middle Aged; D017145:Models, Educational; D016294:Models, Nursing; D009736:Nursing Process; D010347:Patient Care Planning; D013850:Thinking | Nurse education today | 1,998 | |
Hyalinizing clear cell carcinoma of the oral cavity and of the parotid gland. | Hyalinizing clear cell carcinoma (HCCC) is a rare, recently described tumor of salivary gland origin. Differential diagnosis includes benign lesions as clear cell change in a pleomorphic adenoma or in oncocytoma and malignant tumors - i.e. epithelial-myoepithelial carcinoma, polymorphous low-grade adenocarcinoma, mucoe... | 10.1159/000027639 | 9,892,871 | D000230:Adenocarcinoma; D018262:Adenocarcinoma, Clear Cell; D018266:Adenocarcinoma, Sebaceous; D018249:Adenoma, Oxyphilic; D008949:Adenoma, Pleomorphic; D000328:Adult; D002277:Carcinoma; D018267:Carcinoma, Acinar Cell; D018277:Carcinoma, Mucoepidermoid; D002292:Carcinoma, Renal Cell; D002294:Carcinoma, Squamous Cell; D... | ORL; journal for oto-rhino-laryngology and its related specialties | 1,999 | |
Arsenate removal using a combination treatment of precipitation and nanofiltration. | A combination treatment of Ca-precipitation and nanofiltration membrane was studied to remove arsenate from water. The selected nanofiltration membrane was an amphoteric charged membrane, proved by the results of ATR-FTIR spectra and zeta potential. The arsenate and calcium removal efficiencies had the lowest values at... | 10.2166/wst.2012.833 | 22,233,908 | D001149:Arsenates; D002118:Calcium; D011232:Chemical Precipitation; D005374:Filtration; D006863:Hydrogen-Ion Concentration; D013058:Mass Spectrometry; D008567:Membranes, Artificial; D036103:Nanotechnology; D017550:Spectroscopy, Fourier Transform Infrared; D014874:Water Pollutants, Chemical; D018508:Water Purification | Water science and technology : a journal of the International Association on Water Pollution Research | 2,012 | D001149:Arsenates; D008567:Membranes, Artificial; D014874:Water Pollutants, Chemical; D002118:Calcium |
Renal and humoral effects of ibopamine, a dopamine agonist, in patients with liver cirrhosis. | We investigated the renal and humoral effects of short-term administration of ibopamine, an orally active dopamine agonist, in patients with liver cirrhosis. The patients were divided into two groups on the basis of sodium excretion with a constant sodium intake of 40 mEq/d. We also compared the effects of ibopamine wi... | 1,967,522 | D000328:Adult; D000368:Aged; D000450:Aldosterone; D003846:Deoxyepinephrine; D004232:Diuretics; D004298:Dopamine; D015259:Dopamine Agents; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney; D008103:Liver Cirrhosis; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D012083:Renin | Archives of internal medicine | 1,990 | D004232:Diuretics; D015259:Dopamine Agents; D000450:Aldosterone; C023487:ibopamine; D012083:Renin; D003846:Deoxyepinephrine; D004298:Dopamine | |
Onset of spontaneous pneumothorax and the synodic lunar cycle. | The relation between spontaneous pneumothorax events and synodic lunar cycle was studied in a retrospective analysis of patients with a first or recurrent spontaneous pneumothorax. The study included a total of 244 patients, 203 males and 41 females. The data were arranged along the first (new moon) to 28th day (one da... | 10.1054/mehy.2001.1432 | 11,735,326 | D005260:Female; D006801:Humans; D008297:Male; D016081:Moon; D011030:Pneumothorax; D012189:Retrospective Studies | Medical hypotheses | 2,001 | |
Behavioral and neuropharmacological characterization of nicotine as a conditional stimulus. | In rats, the pharmacological (interoceptive) effects of 0.4 mg/kg nicotine can serve as a conditional stimulus in a Pavlovian conditioning task. Nicotine administration is paired with intermittent access to a liquid sucrose unconditional stimulus; sucrose is withheld on saline sessions. An increase in sucrose receptacl... | 10.1016/j.ejphar.2007.01.046 | 17,343,849 | D000818:Animals; D001522:Behavior, Animal; D003214:Conditioning, Classical; D003463:Cues; D004193:Discrimination Learning; D004298:Dopamine; D004305:Dose-Response Relationship, Drug; D005795:Generalization, Stimulus; D008297:Male; D009538:Nicotine; D018722:Nicotinic Agonists; D051381:Rats; D017207:Rats, Sprague-Dawley;... | European journal of pharmacology | 2,007 | D018722:Nicotinic Agonists; D011954:Receptors, Dopamine; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D011978:Receptors, Nicotinic; D013395:Sucrose; D009538:Nicotine; D004298:Dopamine |
Safety and efficacy of treatment with liposomal amphotericin B in elderly patients at least 65 years old with hematological diseases. | The safety and efficacy of treatment with liposomal amphotericin B (L-AMB) in elderly patients has not been clarified, especially in Japanese patients. Therefore, we retrospectively analyzed 33 elderly patients with hematological diseases of at least 65 years old who received L-AMB between 2009 and 2012. Their clinical... | 26,908,230 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B; D000935:Antifungal Agents; D005260:Female; D006402:Hematologic Diseases; D006801:Humans; D016867:Immunocompromised Host; D000072742:Invasive Fungal Infections; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy | 2,016 | D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B | |
Installation and first operation of the International Fusion Materials Irradiation Facility injector at the Rokkasho site. | The International Fusion Materials Irradiation Facility (IFMIF) linear IFMIF prototype accelerator injector dedicated to high intensity deuteron beam production has been designed, built, and tested at CEA/Saclay between 2008 and 2012. After the completion of the acceptance tests at Saclay, the injector has been fully s... | 10.1063/1.4932977 | 26,931,944 | The Review of scientific instruments | 2,016 | ||
Single nodule on the glans penis: metastatic lesion from an unusual carcinoma of the prostate. | An inflammatory nodule developed on the glans penis of a 79-year-old man. Histological examination confirmed the diagnosis of metastasis from a carcinoma of the prostate. This case is of interest in view of the rarity of this metastatic localization and the very unusual microscopic pattern of the primary cancer (epider... | 10.1159/000248815 | 3,653,464 | D000368:Aged; D002294:Carcinoma, Squamous Cell; D006801:Humans; D007249:Inflammation; D008297:Male; D010412:Penile Neoplasms; D011471:Prostatic Neoplasms | Dermatologica | 1,987 | |
Use and Value of the 7-Item Binge Eating Disorder Screener in Clinical Practice. | OBJECTIVE
To evaluate physician knowledge of and attitudes about binge-eating disorder (BED) and the value and ease-of-use of the 7-item Binge Eating Disorder Screener (BEDS-7) in clinical practice.
METHODS
Two internet surveys (wave 1: April 15-May 6, 2015; wave 2: August 19-25, 2015) were administered to primary ca... | 28,682,526 | D001291:Attitude of Health Personnel; D056912:Binge-Eating Disorder; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D020407:Internet; D008137:Longitudinal Studies; D008297:Male; D058007:Physicians, Primary Care; D011569:Psychiatric Status Rating Scales; D011570:Psychiatry; D011795:Survey... | The primary care companion for CNS disorders | 2,017 | ||
Functional gastrointestinal disorders in children from low socio-economic status and Helicobacter pylori infection. | BACKGROUND
Most studies on functional gastrointestinal disorders (FGIDs) in children are based on data from the northern hemisphere. Scientific reports are arising in South American population, but little is still known about children from low socio-economic status (SES), where Helicobacter pylori infection is endemic.... | 10.1111/cch.12486 | 28,707,297 | D000293:Adolescent; D001944:Breath Tests; D002648:Child; D002677:Chile; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D005767:Gastrointestinal Diseases; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D... | Child: care, health and development | 2,018 | |
Malformations in offspring of women with epilepsy: a prospective study. | PURPOSE
The incidence of malformations among infants of mothers with epilepsy treated with antiepileptic drugs (AEDs) during pregnancy is higher than that found in the general population. The aim of this study was to contribute to providing a definition of the rate of congenital anomalies in the offspring of mothers wi... | 10.1111/j.1528-1157.1999.tb00851.x | 10,487,185 | D000014:Abnormalities, Drug-Induced; D000927:Anticonvulsants; D002220:Carbamazepine; D015897:Comorbidity; D000013:Congenital Abnormalities; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004827:Epilepsy; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:I... | Epilepsia | 1,999 | D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin |
Testing green coffee for ochratoxin A, part II: Observed distribution of ochratoxin A test results. | The suitability of 4 theoretical distributions (normal, lognormal, negative binomial, and gamma) to predict the observed distribution of ochratoxin A (OTA) in green coffee was investigated. One symmetrical and 3 positively skewed theoretical distributions were each fitted to 25 empirical distributions of OTA test resul... | 16,001,852 | D002021:Buffers; D002138:Calibration; D002623:Chemistry Techniques, Analytical; D002846:Chromatography, Affinity; D002853:Chromatography, Liquid; D003069:Coffee; D004305:Dose-Response Relationship, Drug; D005504:Food Analysis; D005506:Food Contamination; D009793:Ochratoxins; D015203:Reproducibility of Results; D012965:... | Journal of AOAC International | 2,005 | D002021:Buffers; D003069:Coffee; D009793:Ochratoxins; C025589:ochratoxin A; D012965:Sodium Chloride | |
Community-based screening for pre-hypertension among military active duty personnel. | OBJECTIVE
To determine the prevalence of both pre-hypertension and hypertension, and risk factors associated with the newly diagnosed Saudi military active duty personnel.
METHODS
A community-based cross-sectional screening of 1238 Saudi military active duty service personnel was conducted during the period from Sept... | 19,082,233 | D000328:Adult; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension; D008019:Life Style; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D015999:Multivariate Analysis; D009765:Obesity; D015995:Prevalence; D012529:Saudi Arabia; D055815:Young Adult | Saudi medical journal | 2,008 | ||
Postmerger Gravitational-Wave Signatures of Phase Transitions in Binary Mergers. | With the first detection of gravitational waves from a binary system of neutron stars GW170817, a new window was opened to study the properties of matter at and above nuclear-saturation density. Reaching densities a few times that of nuclear matter and temperatures up to 100 MeV, such mergers also represent potential s... | 10.1103/PhysRevLett.124.171103 | 32,412,268 | Physical review letters | 2,020 | ||
Harmful effect of repetitive intravenous iodinated contrast media administration on the long-term renal function of patients with early gastric cancer. | This retrospective study investigated whether repetitive exposure to intravenous iodinated contrast media (ICM) affects long-term renal function in patients who undergo curative surgery for early gastric cancer (EGC) collected from the Korean Health Insurance and Review Assessment (HIRA) database. Patients diagnosed wi... | 10.1038/s41598-023-46773-x | 37,945,805 | D006801:Humans; D003287:Contrast Media; D013274:Stomach Neoplasms; D012189:Retrospective Studies; D016022:Case-Control Studies; D017613:Iodine Compounds; D051436:Renal Insufficiency, Chronic; D007348:Insurance, Health; D007668:Kidney; D012307:Risk Factors | Scientific reports | 2,023 | D003287:Contrast Media; D017613:Iodine Compounds |
A Rare Cause of Pedunculated Polyps Caused by Strongyloides. | Introduction
Strongyloidiasis is a systemic disease caused by the nematode Strongyloides stercoralis. Strongyloides is unique among parasites in that it can remain undetected for decades. Although patients may present with the typical symptoms of a skin rash, cough or diarrhoea, a rare manifestation of infection is pse... | 10.12890/2021_003008 | 35,402,330 | European journal of case reports in internal medicine | 2,022 | ||
Acquired nasolacrimal duct obstruction: clinical and histological findings of 275 cases. | BACKGROUND
Acquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by local nonspecific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction is caused by malignancies. Our aim was to investigate lacr... | 10.1186/s12886-021-02185-x | 34,986,808 | D003608:Dacryocystorhinostomy; D006801:Humans; D007765:Lacrimal Apparatus; D007767:Lacrimal Duct Obstruction; D009301:Nasolacrimal Duct; D012189:Retrospective Studies | BMC ophthalmology | 2,022 | |
Structural features affecting chiral discrimination of terpene derivatives on a carbamated amylose stationary phase. | The chiral discrimination of enantiomeric derivatives of alpha-pinene was studied using amylose tris(3,5-dimethylphenylcarbamate) as a chromatographic stationary phase. The effect of structural features of these enantiomeric pairs on their chromatographic resolution was systematically studied to understand further the ... | 10.1016/0021-9673(94)87003-9 | 8,199,706 | D000688:Amylose; D000081008:Bicyclic Monoterpenes; D002219:Carbamates; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D039821:Monoterpenes; D048448:Phenylcarbamates; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013729:Terpenes | Journal of chromatography. A | 1,994 | D000081008:Bicyclic Monoterpenes; D002219:Carbamates; D039821:Monoterpenes; D048448:Phenylcarbamates; D013729:Terpenes; C080033:Chiralpak AD; D000688:Amylose; C005451:alpha-pinene |
[Quality of life after acetabulum and pelvic ring fractures. Correlation of long-term results with the "Injury Severity Score" (ISS)]. | Patients with acetabular (AF) and pelvic ring fractures (BrF) make heavy demands on hospital resources and face difficulties in rehabilitation. From the patients' point of view, milestones in recovery are quality of life and return to productivity. We studied 42 patients with acetabular and 64 patients with pelvic ring... | 10.1007/s00132-002-0311-3 | 12,149,931 | D000077:Acetabulum; D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D004185:Disability Evaluation; D005260:Female; D005593:Fracture Fixation, Internal; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010384:... | Der Orthopade | 2,002 | |
Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy. | BACKGROUND
Alpha-synuclein (α-syn) aggregation represents the pathological hallmark of α-synucleinopathies like Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Toll-like receptors (TLRs) are a family of highly conserved molecules that recognize pathogen-associated molecular... | 10.1186/s13024-017-0195-7 | 28,676,095 | D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008050:Lipid A; D008297:Male; D008822:Mice, Transgenic; D019578:Multiple System Atrophy; D009474:Neurons; D010300:Parkinson Disease; D013378:Substantia Nigra; D051197:Toll-Like Receptor 4; D051844:alpha-Synuclein | Molecular neurodegeneration | 2,017 | D008050:Lipid A; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; D051844:alpha-Synuclein; C048436:monophosphoryl lipid A |
The in vitro pharmacological profile of SK&F 106760, a novel GPIIB/IIIA antagonist. | The properties of SK&F 106760 [N alpha-acetyl-cyclo(S,S)-cysteinyl-N alpha-methyl-arginyl-glycyl-aspartyl-penicillamine-amide] as a GPIIb/IIIa antagonist have been studied in vitro and compared with those of the parent molecule, Ac-RGDS-NH2. Ac-RGDS-NH2 inhibited biotinylated fibrinogen binding to purified human GPIIb/... | 10.1016/0049-3848(94)90063-9 | 7,974,388 | D000595:Amino Acid Sequence; D000818:Animals; D004285:Dogs; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides; D010456:Peptides, Cyclic; D010979:Platelet Function Tests; D010980:Platelet Membrane Glycoproteins; D011485:Protein Binding | Thrombosis research | 1,994 | D009842:Oligopeptides; D010456:Peptides, Cyclic; D010980:Platelet Membrane Glycoproteins; C060414:acetyl-arginyl-glycyl-aspartyl-serinamide; C071275:SK&F 106760 |
Overview of the radiology, histology, and bone morphogenetic protein expression during distraction osteogenesis of the mandible. | INTRODUCTION
Distraction osteogenesis (DO) is a form of in vivo tissue engineering during which an osteotomy and controlled distraction are used to lengthen bone. The molecular signals that govern distraction-induced bone formation have not been fully elucidated. Specifically, the role of bone morphogenetic proteins (B... | 10.2310/7070.2002.34305 | 12,512,892 | D000818:Animals; D019485:Bone Morphogenetic Proteins; D019902:Chondrocytes; D007150:Immunohistochemistry; D008297:Male; D008334:Mandible; D010006:Osteoblasts; D019857:Osteogenesis, Distraction; D011817:Rabbits; D011859:Radiography | The Journal of otolaryngology | 2,002 | D019485:Bone Morphogenetic Proteins |
Origin of Outstanding Phase and Moisture Stability in a Na3P1-xAsxS4 Superionic Conductor. | Sodium ion (Na) solid-state electrolytes (SSEs) are critical to address notorious safety issues associated with liquid electrolytes used in the current Na ion batteries. Fulfilling multiple innovations is a grand challenge but is imperative for advanced Na ion SSEs, such as a combination of high ionic conductivity and ... | 10.1021/acsami.7b03606 | 28,453,260 | ACS applied materials & interfaces | 2,017 | ||
Clarification of contraceptive drug pharmacokinetics in obesity. | Related to concerns about the role of obesity in the efficacy of contraceptive drugs, a review of the literature was carried out in regard to the pharmacokinetics of ethinyl estradiol and various progestins given by various routes of administration. Most studies show that obese women exhibit modestly lower plasma conce... | 10.1016/j.contraception.2016.08.003 | 27,542,520 | D001835:Body Weight; D003276:Contraceptives, Oral; D004997:Ethinyl Estradiol; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D009765:Obesity | Contraception | 2,017 | D003276:Contraceptives, Oral; D004997:Ethinyl Estradiol; D016912:Levonorgestrel |
Generation of a ribozyme-adenoviral vector against K-ras mutant human lung cancer cells. | ras mutations represent one of the most common oncogenetic lesions in human non-small cell lung cancer (NSCLC) and adversely affect the survival of patients afflicted with this disease. ras-directed gene therapy in the past employed primarily antisense oligonucleotides (AS-ODN) or expression vectors (such as a viral ve... | 10.1385/mb:15:1:39 | 10,911,621 | D002289:Carcinoma, Non-Small-Cell Lung; D002460:Cell Line; D004252:DNA Mutational Analysis; D005229:Fatty Acids, Monounsaturated; D011905:Genes, ras; D005821:Genetic Techniques; D005822:Genetic Vectors; D006801:Humans; D008081:Liposomes; D008175:Lung Neoplasms; D009154:Mutation; D010957:Plasmids; D000644:Quaternary Amm... | Molecular biotechnology | 2,000 | D005229:Fatty Acids, Monounsaturated; D008081:Liposomes; D000644:Quaternary Ammonium Compounds; D016337:RNA, Catalytic; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane |
Gene mutations and stroke in the young adult. | BACKGROUND
The purpose of this study is to evaluate the existence of the genetic mutation in the different types of cerebral and spinal strokes in previously healthy young adults.
METHODS
We performed a retrospective study of the medical records of 35 young adults who presented to our institution with the diagnosis o... | 10.1016/j.jstrokecerebrovasdis.2014.05.027 | 25,238,925 | D000328:Adult; D000375:Aging; D005165:Factor V; D005176:Factor XIII; D005260:Female; D005340:Fibrinogen; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation; D011516:Prothrombin; D012189:Retrospective Studies; D012307:Risk Facto... | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association | 2,014 | D005165:Factor V; D011516:Prothrombin; D005340:Fibrinogen; D005176:Factor XIII; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2) |
The etiology of early childhood diarrhea: a community study from Guinea-Bissau. | A potential enteropathogen was found in 50% of 1219 diarrheal episodes and 48% of 511 asymptomatic controls in a 1-year community study of childhood diarrhea. Rotavirus (3% of episodes), Cryptosporidium species (6%), and enteropathogenic Escherichia coli (EPEC) with EPEC adherence factor (4%) were more prevalent in cas... | 10.1093/infdis/169.3.581 | 8,158,030 | D002648:Child; D002675:Child, Preschool; D003967:Diarrhea; D005260:Female; D006169:Guinea-Bissau; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012621:Seasons | The Journal of infectious diseases | 1,994 | |
A new look at dry eye disease and its treatment. | This review examines the impact of moderate to severe dry eye disease on daily life and medical-resource utilization. The results suggest that current treatment paradigms can lead to unacceptable costs in both quality of life and progressive use of healthcare resources. Evidence linking this disease to T-cell-mediated ... | 10.1007/BF02854841 | 11,010,059 | D000328:Adult; D000368:Aged; D017281:Cost of Illness; D015352:Dry Eye Syndromes; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014481:United States | Advances in therapy | 2,000 | |
Stereotypes Can "Get Under the Skin": Testing a Self-Stereotyping and Psychological Resource Model of Overweight and Obesity. | The authors draw upon social, personality, and health psychology to propose and test a self-stereotyping and psychological resource model of overweight and obesity. The model contends that self-stereotyping depletes psychological resources, namely self-esteem, that help to prevent overweight and obesity. In support of ... | 10.1111/josi.12057 | 25,221,353 | The Journal of social issues | 2,014 | ||
Immobilization of DNA on Biosensing Devices with Nitrogen Mustard-Modified Linkers. | Immobilization of DNA is an important step in relation to DNA-based biosensors and bioassays with multiple applications. This unit describes synthesis and applications of novel bifunctional linker molecules containing nitrogen mustard and one of two types of functional groups: cyclic disulfide or biotin. Two ways of im... | 10.1002/cpnc.85 | 31,038,292 | D000478:Alkylation; D000818:Animals; D015374:Biosensing Techniques; D001710:Biotin; D004247:DNA; D058645:Denaturing Gradient Gel Electrophoresis; D004220:Disulfides; D006046:Gold; D008466:Mechlorethamine; D051379:Mice | Current protocols in nucleic acid chemistry | 2,019 | D004220:Disulfides; D008466:Mechlorethamine; D001710:Biotin; D006046:Gold; D004247:DNA |
Treatment of fetal distress during diabetic keto-acidosis. | A case of diabetic acidosis during pregnancy is presented in which the fetal heart rate tracing demonstrated late decelerations. Sodium bicarbonate, intravenous fluids and insulin treatment resulted in correction of both the maternal acidosis and the abnormal fetal heart rate tracings. The rationale for bicarbonate the... | 415,135 | D000328:Adult; D001639:Bicarbonates; D016883:Diabetic Ketoacidosis; D005260:Female; D005316:Fetal Distress; D005318:Fetal Heart; D006801:Humans; D007328:Insulin; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D014882:Water-Electrolyte Balance | The Journal of reproductive medicine | 1,978 | D001639:Bicarbonates; D007328:Insulin | |
Spatial epidemiology of Escherichia coli O157:H7 in dairy cattle in relation to night roosts Of Sturnus vulgaris (European Starling) in Ohio, USA (2007-2009). | The goal of our study was to use spatial scan statics to determine whether the night roosts of European starlings (Sturnus vulgaris) act as point sources for the dissemination of Escherichia coli O157:H7 among dairy farms. From 2007 to 2009, we collected bovine faecal samples (n = 9000) and starling gastrointestinal co... | 10.1111/zph.12092 | 24,279,810 | D000818:Animals; D015373:Bacterial Typing Techniques; D002417:Cattle; D002418:Cattle Diseases; D016000:Cluster Analysis; D004199:Disease Vectors; D004927:Escherichia coli Infections; D019453:Escherichia coli O157; D005243:Feces; D018598:Minisatellite Repeats; D009820:Ohio; D062206:Spatial Analysis; D046749:Starlings | Zoonoses and public health | 2,014 | |
Characterization of Graft Copolymers Synthesized from p-Aminosalicylate Functionalized Monomeric Choline Ionic Liquid. | An ionic liquid based on the monomeric choline, specifically [2-(methacryloyloxy)ethyl]-trimethylammonium chloride (TMAMA), underwent biofunctionalization through an ion exchange reaction with the model drug anion: p-aminosalicylate (PAS), a primary antibiotic for tuberculosis treatment. This modified biocompatible IL ... | 10.3390/pharmaceutics15112556 | 38,004,535 | Pharmaceutics | 2,023 | ||
Comparison of subjective and objective test evaluations for use of Mycobacterium phlei-adsorbed serum in a dot-enzyme-linked immunosorbent assay for diagnosis of paratuberculosis in cattle. | Use of a dot-ELISA with serum adsorbed with Mycobacterium phlei or with nonadsorbed serum was compared. In addition, results attained using visual observation were compared with those obtained using a densitometer. Infection status of cattle was determined by results of culture of feces from a number of cattle with var... | 1,510,315 | D000327:Adsorption; D000818:Animals; D000907:Antibodies, Bacterial; D002417:Cattle; D002418:Cattle Diseases; D003720:Densitometry; D003936:Diagnosis, Computer-Assisted; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces; D008838:Microcomputers; D016927:Mycobacterium avium subsp. paratuberculosis; D009168:Mycobact... | American journal of veterinary research | 1,992 | D000907:Antibodies, Bacterial | |
Antimicrobial activities of three species of family mimosaceae. | The antimicrobial activities of crude methanolic extract of leaves of Acacia nilotica L., Albizia lebbeck L. and Mimosa himalayana Gamble belonging to family mimosaceae were investigated in this research work. Antibacterial activity was studied by agar well diffusion method against one gram-positive Bacillus subtilis a... | 22,186,331 | D000890:Anti-Infective Agents; D052978:Disk Diffusion Antimicrobial Tests; D007887:Fabaceae; D010936:Plant Extracts; D018515:Plant Leaves | Pakistan journal of pharmaceutical sciences | 2,012 | D000890:Anti-Infective Agents; D010936:Plant Extracts | |
Differences and associations of metabolic and vitamin D status among patients with and without sub-clinical hypothyroid dysfunction. | BACKGROUND
Sub-clinical hypothyroid dysfunction, a relatively understudied disorder in the Kingdom of Saudi Arabia (KSA), has significant clinical implications if not properly monitored. Also from KSA, more than 50% of the population suffer from hypovitaminosis D (<50 nmol/l). In this cross-sectional case-control study... | 10.1186/1472-6823-13-31 | 23,962,199 | BMC endocrine disorders | 2,013 | ||
Revisit Spinal Shock: Pattern of Reflex Evolution during Spinal Shock. | When the spinal cord is suddenly severed, all the fundamental functions of the spinal cord below the level of injury including the spinal cord reflexes are immediately depressed, which is referred to as spinal shock. The resolution of spinal shock occurs over a period of days to months, and spinal shock slowly transiti... | 10.13004/kjnt.2018.14.2.47 | 30,402,418 | Korean journal of neurotrauma | 2,018 | ||
Why do Mines Fail to Obtain a Social License to Operate?: Insights from the Proposed Kallak Iron Mine (Sweden) and the Prosperity/New Prosperity Gold-Copper Mine (Canada). | Opposition to mines endures even in countries with relatively strong environmental assessment processes and regulations. Why proposed mines fail to obtain a social license to operate is analyzed by developing a framework comprised of three concepts-process legitimacy, distributional outcomes, and values compatibility-d... | 10.1007/s00267-021-01587-3 | 35,064,807 | D000818:Animals; D003300:Copper; D013548:Sweden; D002170:Canada; D001955:British Columbia; D008906:Mining; D012053:Reindeer | Environmental management | 2,023 | D003300:Copper |
Evidence that TET protein functions as a multimer in the inner membrane of Escherichia coli. | The inner membrane TET (TetA) protein, which is involved in Tn10-mediated microbial tetracycline resistance, consists of two domains, alpha and beta, both of which are needed for tetracycline resistance and efflux (M.S. Curiale, L.M. McMurry, and S.B. Levy, J. Bacteriol. 157:211-217, 1984). Since tetracycline-sensitive... | 10.1128/jb.170.4.1715-1720.1988 | 3,280,550 | D000469:Alkaline Phosphatase; D001426:Bacterial Proteins; D002462:Cell Membrane; D003001:Cloning, Molecular; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D009154:Mutation; D010957:Plasmids; D011815:R Factors; D011993:Recombinant Fus... | Journal of bacteriology | 1,988 | D001426:Bacterial Proteins; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C034811:tetracycline resistance-encoding transposon repressor protein; D000469:Alkaline Phosphatase; D013752:Tetracycline |
[Pathophysiology and diagnosis of cardio-renal syndrome: actual picture and future prospectives]. | The cardiorenal syndrome (CRS) indicates how close the relationship is between heart and kidney during failure of these organs. At present, the classification of the syndrome includes five types of CRS: types I and II which are strictly related to initial heart failure (both acute and chronic), types III and IV which i... | 24,402,629 | D015415:Biomarkers; D059347:Cardio-Renal Syndrome; D005544:Forecasting; D006801:Humans; D007668:Kidney; D007674:Kidney Diseases; D011446:Prospective Studies; D051437:Renal Insufficiency | Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia | 2,013 | D015415:Biomarkers | |
Repeat abortion in Denmark: an analysis based on national record linkage. | The abortion registration system maintained by the Danish government permits an analysis of abortion incidence by individual. Using computer techniques to sort all the abortion records for the 15-month period from October 1973, when the abortion law was liberalized, through December 1974, it has been possible to determ... | 877,981 | D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D003710:Demography; D003718:Denmark; D005260:Female; D006801:Humans; D007256:Information Systems; D008875:Middle Aged; D011247:Pregnancy; D011996:Records; D012042:Registries; D012424:Rural Population; D012959:Socioeconomic... | Studies in family planning | 1,977 | ||
A case report of arthroscopic treatment of a retro-patellar GCTTS causing anterior knee pain. | INTRODUCTION AND IMPORTANCE
Giant cell tumor of tendon sheath (GCTTS) is a common soft tissue tumor in hands and feet; however, it is rare in knee joints.
CASE PRESENTATION
We present a case of a 52-year-old female who had a retropatellar tendon giant cell tumor (GCT) in the right knee, causing vague anterior knee pa... | 10.1016/j.ijscr.2023.108089 | 37,018,943 | International journal of surgery case reports | 2,023 | ||
Optimized pulse sequences for magnetic resonance measurement of aortic cross sectional areas. | This study was done to improve the ability of magnetic resonance (MR) imaging to provide clear cross-sectional images of the ascending and descending aorta in diastole. The study was motivated by interest in measuring the regional compliance of the ascending aorta, which requires determination of the change in cross se... | 10.1016/0730-725x(91)90433-m | 1,881,264 | D001011:Aorta; D003187:Compliance; D003971:Diastole; D006801:Humans; D008279:Magnetic Resonance Imaging | Magnetic resonance imaging | 1,991 | |
marY2N, a LINE-like non-long terminal repeat (non-LTR) retroelement from the ectomycorrhizal homobasidiomycete Tricholoma matsutake. | A LINE-like non-LTR retroelement designated marY2N was cloned from the ectomycorrhizal homobasidiomycete Tricholoma matsutake. marY2N has open reading frames that correspond to gag and pol, and a putative promoter and consensus sequences common to those of the mutators from fruit flies. While it is common to T. matsuta... | 10.1271/bbb.65.2301 | 11,758,927 | D001483:Base Sequence; D001487:Basidiomycota; D015139:Blotting, Southern; D003001:Cloning, Molecular; D004271:DNA, Fungal; D020084:Long Interspersed Nucleotide Elements; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016366:Open Reading Frames; D020079:Terminal Repeat Sequences | Bioscience, biotechnology, and biochemistry | 2,001 | D004271:DNA, Fungal |
Magnetic labeling of primary murine monocytes using very small superparamagnetic iron oxide nanoparticles. | Due to their very small size, nanoparticles can interact with all cells in the central nervous system. One of the most promising nanoparticle subgroups are very small superparamagnetic iron oxide nanoparticles (VSOP) that are citrate coated for electrostatic stabilization. To determine their influence on murine blood-d... | 10.4103/1673-5374.336873 | 35,259,855 | Neural regeneration research | 2,022 | ||
More Than Data Stories: Broadening the Role of Visualization in Contemporary Journalism. | Data visualization and journalism are deeply connected. From early infographics to recent data-driven storytelling, visualization has become an integrated part of contemporary journalism, primarily as a communication artifact to inform the general public. Data journalism, harnessing the power of data visualization, has... | 10.1109/TVCG.2023.3287585 | 37,339,040 | IEEE transactions on visualization and computer graphics | 2,023 | ||
Tuberculous abdominal cocoon: original article. | BACKGROUND
Tuberculous abdominal cocoon is a rare disease, and diagnosis is seldom made preoperatively. The bowel is encased in a membrane in a cocoon-like fashion. Histopathology is confirmatory.
METHODS
This prospective case note review was a study of patients diagnosed with tuberculous abdominal cocoon from April ... | 21,153,942 | D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007415:Intestinal Obstruction; D008297:Male; D008875:Middle Aged; D009852:Omentum; D011446:Prospective Studies; D011859:Radiography; D014376:Tuberculosis | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES | 2,010 | ||
Update on the glomerular filtration barrier. | PURPOSE OF REVIEW
The nephrology community lacks a unified view of protein sieving through the glomerular capillary wall. The glomerular capillary wall consists of three distinct but closely interacting layers: the fenestrated endothelium, with its glycocalyx; the podocytes, with their interdigitated foot processes and... | 10.1097/mnh.0b013e3283296044 | 19,374,010 | D000818:Animals; D004727:Endothelium; D005374:Filtration; D050533:Glomerular Basement Membrane; D006801:Humans; D007678:Kidney Glomerulus; D007684:Kidney Tubules; D050199:Podocytes; D011506:Proteins | Current opinion in nephrology and hypertension | 2,009 | D011506:Proteins |
Risk assessment and management to ensure health and safety at work. | Mammet, the charge nurse on a surgical ward, was asked to carry out a risk assessment on health and safety. He had never been taught such an activity and needed to seek advice. | 10.12968/bjon.2002.11.21.10927 | 12,514,470 | D005161:Facility Regulation and Control; D019983:Guideline Adherence; D006801:Humans; D016272:Occupational Health; D018570:Risk Assessment; D012308:Risk Management; D006113:United Kingdom | British journal of nursing (Mark Allen Publishing) | 2,002 | |
A model of metabolic changes in respiration-deficient human cells. | Cells lacking aerobic metabolism because of damaged mtDNA accumulate in many postmitotic tissues in the course aging. Although being only a small fraction of cells, they might play a major role in oxidative stress affecting the whole body. However, it remains unclear how such cells, which are under normal circumstances... | 10.1089/rej.2006.0527 | 17,559,336 | D000375:Aging; D019069:Cell Respiration; D016922:Cellular Senescence; D004272:DNA, Mitochondrial; D006019:Glycolysis; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D018384:Oxidative Stress; D010100:Oxygen; D010101:Oxygen Consumption; D010829:Physiological Phenomena; D019802:Succinic Acid; D01... | Rejuvenation research | 2,007 | D004272:DNA, Mitochondrial; D014233:Tricarboxylic Acids; D019802:Succinic Acid; D010100:Oxygen |
The Importance of Evaluating Frailty and Social-behavioral Factors for Managing Drugs and Dialysis Prescription in Elderly Patients. | Ageing is characterized by a progressive loss of complexity, which is an essential condition for making the organism capable of keeping homeostasis. Thus, senile loss of complexity makes old individuals frail: a syndrome characterized by the presence of shrinking (sarcopenia), weakness, poor endurance and energy, slown... | 10.1055/s-0035-1565127 | 26,575,015 | D000369:Aged, 80 and over; D000375:Aging; D002908:Chronic Disease; D003863:Depression; D018450:Disease Progression; D004522:Educational Status; D016330:Frail Elderly; D005919:Glomerular Filtration Rate; D006801:Humans; D012934:Social Isolation; D012959:Socioeconomic Factors | Drug research | 2,016 | |
Chiriquitoxin, a new tool for mapping ionic channels. | Chiriquitoxin is a new natural analog of tetrodotoxin in which the -CH2OH group on C6 has been replaced with a yet unidentified group consisting of 104 mass units. It is unique in being the only known stable analog to be equally potent as tetrodotoxin in blocking the sodium channel. It additionally interferes with the ... | 6,262,484 | D000664:Amphibian Venoms; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D004594:Electrophysiology; D066298:In Vitro Techniques; D007473:Ion Channels; D008564:Membrane Potentials; D008954:Models, Biological; D009132:Muscles; D011188:Potassium; D011894:Rana pipiens; D012964:Sodium; D013779:Tetrodo... | The Journal of pharmacology and experimental therapeutics | 1,981 | D000664:Amphibian Venoms; D007473:Ion Channels; D013779:Tetrodotoxin; C015741:chiriquitoxin; D012964:Sodium; D011188:Potassium | |
Synthesis and thermal decomposition behaviors of magnesium borohydride ammoniates with controllable composition as hydrogen storage materials. | An ammonia-redistribution strategy for synthesizing metal borohydride ammoniates with controllable coordination number of NH(3) was proposed, and a series of magnesium borohydride ammoniates were easily synthesized by a mechanochemical reaction between Mg(BH(4))(2) and its hexaammoniate. A strong dependence of the dehy... | 10.1002/asia.201200970 | 23,192,895 | Chemistry, an Asian journal | 2,013 | ||
Effect of psoriasis therapy on VEGF and its soluble receptors serum concentrations. | BACKGROUND
Vascular endothelial growth factor (VEGF) is recognized a pivotal pro-angiogenic factor responsible for new blood vessels formation in psoriatic lesion.
OBJECTIVES
The aim of the study was to analyse serum concentrations of VEGF and its soluble receptors (sVEGF) R1 and R2 in psoriatic patients before and a... | 10.1111/j.1468-3083.2011.04053.x | 21,418,334 | D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011565:Psoriasis; D040262:Receptors, Vascular Endothelial Growth Factor; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A | Journal of the European Academy of Dermatology and Venereology : JEADV | 2,012 | D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor |
Prevalence of and Risk Factors Associated With Nonfatal Overdose Among Veterans Who Have Experienced Homelessness. | Importance
Individuals with a history of homelessness are at increased risk for drug or alcohol overdose, although the proportion who have had recent nonfatal overdose is unknown. Understanding risk factors associated with nonfatal overdose could guide efforts to prevent fatal overdose.
Objectives
To determine the pr... | 10.1001/jamanetworkopen.2020.1190 | 32,181,829 | D000328:Adult; D001741:Black or African American; D000368:Aged; D062787:Drug Overdose; D005260:Female; D006703:Ill-Housed Persons; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D057216:Propensity Score; D012307:Risk Factors; D014481:United States; D014493:United States Depar... | JAMA network open | 2,020 | |
Stability of 2H- and 1T-MoS2 in the presence of aqueous oxidants and its protection by a carbon shell. | Two-dimensional molybdenum disulfide (MoS2) is emerging as a catalyst for energy and environmental applications. Recent studies have suggested the stability of MoS2 is questionable when exposed to oxidizing conditions found in water and air. In this study, the aqueous stability of 2H- and 1T-MoS2 and 2H-MoS2 protected ... | 10.1039/d0ra00788a | 35,497,240 | RSC advances | 2,020 | ||
Dried blood spots collected on filter paper: an international resource for the diagnosis and genetic characterization of human immunodeficiency virus type-1. | The collection of dried blood spots (DBS) on filter paper provides a powerful approach for the development of large-scale, population-based screening programs. DBS methods are particularly valuable in developing countries and isolated rural regions where resources are limited. Large numbers of field specimens can be ec... | 10.1590/s0074-02761996000300019 | 9,040,855 | D015492:AIDS Serodiagnosis; D016915:AIDS Vaccines; D000163:Acquired Immunodeficiency Syndrome; D000595:Amino Acid Sequence; D001483:Base Sequence; D001800:Blood Specimen Collection; D017931:DNA Primers; D004351:Drug Resistance; D005374:Filtration; D014644:Genetic Variation; D015497:HIV-1; D006801:Humans; D007223:Infant... | Memorias do Instituto Oswaldo Cruz | 1,996 | D016915:AIDS Vaccines; D017931:DNA Primers; D015215:Zidovudine |
Glutamate: a potential mediator of inorganic mercury neurotoxicity. | Exposure to mercury vapor (Hg0) produces neurotoxic effects which are for the most part subsequent to its biotransformation in brain to the mercuric cation (Hg2 +), which has an exceptionally strong affinity towards the SH groups in proteins. However, neurologic symptoms are often encountered in subjects in which Hg+ c... | 10.1007/BF02069504 | 8,776,719 | D000818:Animals; D001253:Astrocytes; D002540:Cerebral Cortex; D018698:Glutamic Acid; D008628:Mercury; D009474:Neurons; D051381:Rats | Metabolic brain disease | 1,996 | D018698:Glutamic Acid; D008628:Mercury |
Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. | FOXP3-expressing T regulatory cells (Tregs) can be divided into two distinct subsets: naturally occurring Tregs (nTregs) that develop in the thymus, and induced Tregs (iTregs) that differentiate in peripheral tissues upon exposure to Ag in a tolerogenic environment. Recently it has been proposed that expression of Heli... | 10.4049/jimmunol.1201379 | 23,359,504 | D015703:Antigens, CD; D001081:Apyrase; D060908:CTLA-4 Antigen; D002454:Cell Differentiation; D019070:Cell Lineage; D054405:Chemokine CCL3; D002999:Clone Cells; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors; D015870:Gene Expression; D006801:Humans; D051740:Ikaros Transcription Factor; D016130:Immunophen... | Journal of immunology (Baltimore, Md. : 1950) | 2,013 | D015703:Antigens, CD; C515429:CCL3 protein, human; D060908:CTLA-4 Antigen; D054405:Chemokine CCL3; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C111431:IKZF2 protein, human; D051740:Ikaros Transcription Factor; D007371:Interferon-gamma; D001081:Apyrase; C067869:CD39 antigen |
SORL1 mutations in early- and late-onset Alzheimer disease. | OBJECTIVE
To characterize the clinical and molecular effect of mutations in the sortilin-related receptor (SORL1) gene.
METHODS
We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer disease (LOAD) families followed by functional studies of select variants. The phenotypic... | 10.1212/NXG.0000000000000116 | 27,822,510 | Neurology. Genetics | 2,016 | ||
A second polymorph of β-arteether. | The crystal structure of the title compound, C(17)H(28)O(5), reported here is a polymorph of the structure first reported by El-Feraly, Al-Yahya, Orabi, McPhail & McPhail [J. Nat. Prod. (1992). 55, 878-883]. It is a derivative of the anti-malaria compound artemisinin and consists primarily of three substituted ring sys... | 10.1107/S1600536807062812 | 21,201,924 | Acta crystallographica. Section E, Structure reports online | 2,008 | ||
Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning. | Reduced protein intake during pregnancy decreased maternal hepatic and plasma docosahexaenoic acid concentrations and impaired docosahexaenoic acid accumulation into fetal brain in the rat. The present study investigated whether restriction of maternal protein intake during pregnancy in the rat alters membrane phosphol... | 10.1079/bjn2003909 | 12,908,895 | D000818:Animals; D001921:Brain; D002462:Cell Membrane; D004044:Dietary Proteins; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D005260:Female; D019787:Linoleic Acid; D008099:Liver; D008168:Lung; D009206:Myocardium; D010713:Phosphatidylcholines; D010714:Phosphatidylethanola... | The British journal of nutrition | 2,003 | D004044:Dietary Proteins; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C008757:palmitoleic acid; D019787:Linoleic Acid |
[Anti-bacteria activity of Puraboeo rutescens and Lysionotus pauciflorus]. | OBJECTIVE
Antibacteria activity of compounds from Puraboeo ruescens and Lysionotus pauciflorus was assayed.
METHOD
Disc diffusion was used to isolate compounds in vitro and berberine was positive control. The value of IC50 was assayed by the method of liquid culture. All kinds of chromatography were used to isolate t... | 22,016,971 | D000900:Anti-Bacterial Agents; D001419:Bacteria; D004365:Drugs, Chinese Herbal; D019684:Magnoliopsida | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | 2,011 | D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal | |
Short communication: Altered expression of specificity protein 1 impairs milk fat synthesis in goat mammary epithelial cells. | Specificity protein 1 (encoded by SP1) is a novel transcription factor important for the regulation of lipid metabolism and the normal function of various hormones in model organisms. Its potential role, if any, on ruminant milk fat is unknown. Despite the lower expression of the lipolysis-related gene ATGL (by 44 and ... | 10.3168/jds.2015-10733 | 26,995,134 | D000818:Animals; D051048:Diacylglycerol O-Acyltransferase; D004041:Dietary Fats; D004847:Epithelial Cells; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006041:Goats; D008049:Lipase; D066292:Lipid Droplets; D008066:Lipolysis; D008321:Mammary Glands, Animal; D008892:Milk; D034741:RNA, Small Interfering; D... | Journal of dairy science | 2,016 | D004041:Dietary Fats; D034741:RNA, Small Interfering; D016329:Sp1 Transcription Factor; D014280:Triglycerides; D051048:Diacylglycerol O-Acyltransferase; D008049:Lipase |
Pharmacokinetics of cytosine arabinoside, methotrexate, nimustine and valproic acid in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy. | This report investigates the pharmacokinetics of cytosine arabinoside (Ara-C), methotrexate (MTX), nimustine (ACNU) and valproic acid (VPA) in cerebrospinal fluid (CSF) during CSF perfusion chemotherapy. A 28-year-old Japanese woman with disseminated glioblastoma was, on admission, on a stable oral regimen of prolonged... | 10.1248/bpb.23.784 | 10,864,038 | D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D016543:Central Nervous System Neoplasms; D003131:Combined Modality Therapy; D003561:Cytarabine; D005260:Female; D005909:Glioblastoma; D006801:Humans; D008727:Methotrexate; D015376:Nimustine; D014635:Valproic Acid | Biological & pharmaceutical bulletin | 2,000 | D003561:Cytarabine; D015376:Nimustine; D014635:Valproic Acid; D008727:Methotrexate |
Brain atrophy and employment in multiple sclerosis patients: a 10-year follow-up study. | BACKGROUND
Multiple sclerosis is often associated with unemployment. The contribution of grey matter atrophy to unemployment is unclear.
OBJECTIVES
To identify magnetic resonance imaging biomarkers of grey matter and clinical symptoms associated with unemployment in multiple sclerosis patients.
METHODS
Demographic,... | 10.1177/2055217320902481 | 32,064,116 | Multiple sclerosis journal - experimental, translational and clinical | 2,020 | ||
Frequency of delayed hemolytic transfusion reactions following antibody screening and immediate-spin crossmatching. | In view of the continuing controversy regarding the use of immediate-spin crossmatch procedures in preparing blood for transfusion to patients in whom unexpected clinically significant antibodies have not been found by antibody screening by the indirect antiglobulin test (IAT), a review of 8 years' experience with such... | 10.1046/j.1537-2995.1992.32993110751.x | 1,471,244 | D000368:Aged; D001787:Blood Group Incompatibility; D001788:Blood Grouping and Crossmatching; D003298:Coombs Test; D005260:Female; D006461:Hemolysis; D006801:Humans; D007518:Isoantibodies; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction | Transfusion | 1,992 | D007518:Isoantibodies |
[Misregulation of P-TEFb activity: pathological consequences]. | P-TEFb stimulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA pol II and antagonizing the effects of negative elongation factors. Its cellular availability is controlled by an abundant non coding RNA, conserved through evolution, the 7SK RNA. Together with the HEXIM proteins, 7SK RNA ... | 10.1051/medsci/2012282019 | 22,377,309 | D006332:Cardiomegaly; D004194:Disease; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D015497:HIV-1; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms; D042925:Positive Transcriptional Elongation Factor B; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D014158:Transcription, Ge... | Medecine sciences : M/S | 2,012 | C476123:HEXIM1 protein, human; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D042925:Positive Transcriptional Elongation Factor B |
Flow distribution between the endocrine and exocrine parts of the isolated rat pancreas during perfusion in vitro with different glucose concentrations. | Previous studies in our laboratory have indicated that pancreatic islet blood flow is stimulated by glucose. In an attempt to evaluate to what extent intrapancreatic control mechanisms are involved in the glucose modulation of islet blood flow the distribution of flow between the endocrine and exocrine parts of the rat... | 10.1111/j.1748-1716.1986.tb07852.x | 3,521,204 | D000818:Animals; D003470:Culture Media; D005947:Glucose; D007328:Insulin; D000078790:Insulin Secretion; D007515:Islets of Langerhans; D008297:Male; D008863:Microspheres; D010179:Pancreas; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow | Acta physiologica Scandinavica | 1,986 | D003470:Culture Media; D007328:Insulin; D005947:Glucose |
Printed quit-pack sent to surgical patients at time of waiting list placement improved perioperative quitting. | BACKGROUND
This study aimed to measure the effects of sending a smoking cessation 'quit-pack' to all patients placed on the elective surgical waiting list.
METHOD
Questionnaire-based study before intervention (mid-2011, 177 patients) and after (2012/13, 170 patients) conducted on day of surgery. All were identified a... | 10.1111/ans.12519 | 24,548,659 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017558:Elective Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D059035:Perioperative Period; D011183:Postoperative Complications; D011300:Preoperative Care; D0... | ANZ journal of surgery | 2,014 | |
Diversity and Abundance of House Fly Pupal Parasitoids in Israel, with First Records of Two Spalangia Species. | Filth flies (Diptera: Muscidae), particularly the house fly, Musca domestica L., are global pests of livestock production. In this study, we characterized the fauna of house fly pupal parasitoids in Israel and identified factors affecting their diversity and abundance. The study, which included one round of sampling du... | 10.1093/ee/nvv180 | 26,637,547 | D000818:Animals; D044822:Biodiversity; D006790:Host-Parasite Interactions; D007557:Israel; D007814:Larva; D009117:Muscidae; D010572:Pest Control, Biological; D011156:Population Density; D011679:Pupa; D012621:Seasons; D014863:Wasps | Environmental entomology | 2,016 | |
Investigation of structural dynamics of Thrombocytopenia Cargeeg mutants of human apoptotic cytochrome c: A molecular dynamics simulation approach. | Naturally occurring mutations to cytochrome c (cyt-c) have been identified recently in patients with mild autosomal dominant thrombocytopenia (low platelet levels), which yield cyt-c mutants with enhanced apoptotic activity. However, the molecular mechanism underlying this low platelet production and enhanced apoptosis... | 10.1016/j.bpc.2017.09.004 | 28,958,449 | D001665:Binding Sites; D020134:Catalytic Domain; D045304:Cytochromes c; D006801:Humans; D006860:Hydrogen Bonding; D056004:Molecular Dynamics Simulation; D009154:Mutation; D017433:Protein Structure, Secondary; D012997:Solvents; D013921:Thrombocytopenia | Biophysical chemistry | 2,017 | D012997:Solvents; D045304:Cytochromes c |
Selective depletion of metastatic stem cells as therapy for human colorectal cancer. | Selective elimination of metastatic stem cells (MetSCs) promises to block metastatic dissemination. Colorectal cancer (CRC) cells overexpressing CXCR4 display trafficking functions and metastasis-initiating capacity. We assessed the antimetastatic activity of a nanoconjugate (T22-GFP-H6-FdU) that selectively delivers F... | 10.15252/emmm.201708772 | 30,190,334 | D000818:Animals; D000970:Antineoplastic Agents; D015179:Colorectal Neoplasms; D004195:Disease Models, Animal; D004358:Drug Therapy; D005467:Floxuridine; D006801:Humans; D051379:Mice; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells; D019718:Recep... | EMBO molecular medicine | 2,018 | D000970:Antineoplastic Agents; C527276:CXCR4 protein, human; D019718:Receptors, CXCR4; D005467:Floxuridine |
Coronary microvascular dysfunction in the setting of chronic ischemia is independent of arginase activity. | BACKGROUND
Chronic myocardial ischemia induces endothelial dysfunction in the coronary microcirculation resulting in impaired nitric oxide signaling. This dysfunction has wide-ranging effects including impaired tissue perfusion and is implicated in impairment of the angiogenic process in settings of endothelial dysfunc... | 10.1016/j.mvr.2007.06.008 | 17,707,069 | D000818:Animals; D001119:Arginase; D001120:Arginine; D015153:Blotting, Western; D002908:Chronic Disease; D003326:Coronary Circulation; D003331:Coronary Vessels; D004195:Disease Models, Animal; D004730:Endothelium, Vascular; D005455:Fluorescent Antibody Technique; D016014:Linear Models; D008833:Microcirculation; D017202... | Microvascular research | 2,008 | D014665:Vasodilator Agents; D009569:Nitric Oxide; D001120:Arginine; D052250:Nitric Oxide Synthase Type III; D001119:Arginase |
An integrated biophysical model for predicting the clinical pharmacokinetics of transdermally delivered compounds. | The delivery of therapeutic drugs through the skin is a promising alternative to oral or parenteral delivery routes because dermal drug delivery systems (D3Ss) offer unique advantages, such as controlled drug release over sustained periods and a significant reduction in first-pass effects, thus reducing the required do... | 10.1016/j.ejps.2021.105924 | 34,289,340 | D000279:Administration, Cutaneous; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D012867:Skin; D012869:Skin Absorption | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences | 2,021 | |
Effect of Implementing Quantitative Blood Loss Assessment at the Time of Delivery. | OBJECTIVE
To evaluate the ability of estimated blood loss (EBL) and quantitative blood loss (qBL) to predict need for blood transfusion in women with postpartum hemorrhage (PPH).
STUDY DESIGN
This is a retrospective chart review that identified women with PPH (>1,000 mL for vaginal or cesarean delivery) between Septe... | 10.1055/s-0039-1688823 | 31,087,316 | D000328:Adult; D001803:Blood Transfusion; D036861:Delivery, Obstetric; D005260:Female; D006400:Hematocrit; D006801:Humans; D006473:Postpartum Hemorrhage; D012372:ROC Curve; D012189:Retrospective Studies; D059039:Standard of Care | American journal of perinatology | 2,019 | |
Age-related differences in concomitant hormone release from the superfused rat adenopituitary. | We screened the concomitant release of five adenopituitary (AP) hormones, in vitro, at basal and stimulated conditions, in young and aged (2-3 and 25 months old, respectively) male Fischer 344 rats. The APs of aged rats exhibited significantly higher basal and total release of prolactin, but lower release of luteinizin... | 10.1159/000213269 | 1,959,778 | D000375:Aging; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D010903:Pituitary Gland, Anterior; D010908:Pituitary Hormones, Anterior; D011188:Potassium; D051381:Rats; D011916:Rats, Inbred F344 | Gerontology | 1,991 | D010908:Pituitary Hormones, Anterior; D011188:Potassium |
The Effect of Cyclosporine A on Dermal Fibroblast Cell - Transcriptomic Analysis of Inflammatory Response Pathway. | BACKGROUND
The first immunosuppressive drug - cyclosporine A (CsA) has many unquestioned merits in maintaining organ transplants in patients, as well as, in the treatment of many inflammatory diseases, also associated with cutaneous manifestations. The main task of this drug is to suppress the inflammatory response at ... | 10.2174/1389201021666200416103928 | 32,297,577 | D018929:Cell Culture Techniques; D002460:Cell Line; D002470:Cell Survival; D016572:Cyclosporine; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts; D020869:Gene Expression Profiling; D006801:Humans; D007166:Immunosuppressive Agents; D007249:Inflammation; D020411:Oligonucleotide Array Sequence Analysis; D012... | Current pharmaceutical biotechnology | 2,020 | D007166:Immunosuppressive Agents; D012333:RNA, Messenger; D016572:Cyclosporine |
Pierre Robin sequence: a series of 117 consecutive cases. | A series of 117 cases of Pierre Robin Sequence are classified as isolated (48%), syndromic (35%), and with associated anomalies (17%); the latter group had a poor long-term prognosis. In isolated Pierre Robin Sequence, familial cases and a high incidence of twins were noted. Among syndromic Pierre Robin Sequence, 4 syn... | 10.1067/mpd.2001.117784 | 11,598,609 | D002675:Child, Preschool; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D010375:Pedigree; D010855:Pierre Robin Syndrome; D011379:Prognosis; D015996:Survival Rate | The Journal of pediatrics | 2,001 | |
Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2. | Recent studies have revealed a role of endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) in the regulation of RPE cell activity and survival. Herein, we examined the mechanisms by which the UPR modulates apoptotic signaling in human RPE cells challenged with cigarette smoking extract (CSE). Our ... | 10.1074/jbc.M114.603738 | 25,568,320 | D000111:Acetylcysteine; D017209:Apoptosis; D015153:Blotting, Western; D002460:Cell Line; D002470:Cell Survival; D004268:DNA-Binding Proteins; D059865:Endoplasmic Reticulum Stress; D004847:Epithelial Cells; D016166:Free Radical Scavengers; D015870:Gene Expression; D006801:Humans; D008744:Methylamines; D008928:Mitochondr... | The Journal of biological chemistry | 2,015 | C497249:DDIT3 protein, human; D004268:DNA-Binding Proteins; D016166:Free Radical Scavengers; D008744:Methylamines; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D017382:Reactive Oxygen Species; D000071701:Regulatory Factor X Transcription Factors; D012906:Smoke; D014157:Transcription Factors; D00007171... |
Amyloidosis of the upper aerodigestive tract. | OBJECTIVES/HYPOTHESIS
To delineate the clinical and pathologic characteristics of upper aerodigestive tract amyloidosis with particular attention to laryngeal amyloidosis.
STUDY DESIGN
Retrospective chart review of patients with amyloidosis of Thomas Jefferson University and its affiliated hospitals.
MATERIAL AND M... | 10.1097/00005537-200312000-00007 | 14,660,909 | D000328:Adult; D000686:Amyloidosis; D016208:Databases, Factual; D005260:Female; D006685:Hoarseness; D006801:Humans; D007818:Laryngeal Diseases; D008297:Male; D008875:Middle Aged; D009302:Nasopharyngeal Diseases; D012008:Recurrence; D012189:Retrospective Studies; D014827:Vocal Cords | The Laryngoscope | 2,003 | |
Pharmacological and biochemical characteristics of partially purified GABAB receptor. | Pharmacological and biochemical characteristics of the partially purified gamma-aminobutyric acid (GABA)B receptor using baclofen affinity column chromatography have been examined. The Scatchard analysis of [3H]GABA binding to the purified GABAB receptor showed a linear relationship and the KD and Bmax values were 60 n... | 10.1007/BF00966099 | 1,664,062 | D000818:Animals; D002118:Calcium; D002413:Cations, Divalent; D002417:Cattle; D002540:Cerebral Cortex; D002846:Chromatography, Affinity; D006026:Glycoside Hydrolases; D006160:Guanosine Triphosphate; D008274:Magnesium; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid | Neurochemical research | 1,991 | D002413:Cations, Divalent; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D006160:Guanosine Triphosphate; D006026:Glycoside Hydrolases; D008274:Magnesium; D002118:Calcium |
Primate motor cortex and free arm movements to visual targets in three-dimensional space. III. Positional gradients and population coding of movement direction from various movement origins. | In one experiment, we studied the relations between the frequency of discharge of 274 single cells in the arm area of the motor cortex of the monkey and the actively maintained position of the hand in space. We found that the frequency of discharge of 63.9% of the cells studied was a multilinear function of the positio... | 3,411,363 | D000818:Animals; D001132:Arm; D004576:Electromyography; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D008959:Models, Neurological; D009044:Motor Cortex; D009068:Movement; D009474:Neurons; D011597:Psychomotor Performance; D012044:Regression Analysis | The Journal of neuroscience : the official journal of the Society for Neuroscience | 1,988 | ||
Diagnosis of renal tumors by in vivo proton magnetic resonance spectroscopy. | PURPOSE
To evaluate the diagnostic potential of choline measurements by in vivo magnetic resonance spectroscopy (MR spectroscopy) for diagnosis of renal masses.
METHODS
Twenty-eight patients with 29 renal lesions underwent prospectively preoperative 3 T MR spectroscopy of renal masses before diagnostic tissue confirm... | 10.1007/s00345-014-1272-y | 24,609,220 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002292:Carcinoma, Renal Cell; D002794:Choline; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D06624... | World journal of urology | 2,015 | D015415:Biomarkers; D002794:Choline |
Numerical investigation of flexible Purcell-like integrated microfluidic pumps. | Integrating miniature pumps within microfluidic devices is crucial for advancing point-of-care diagnostics. Understanding the emergence of flow from novel integrated pumping systems is the first step in their successful implementation. A Purcell-like elasto-magnetic integrated microfluidic pump has been simulated in CO... | 10.1063/5.0109263 | 36,313,737 | Journal of applied physics | 2,022 | ||
Malignant Gastrointestinal Stromal Tumor of Rectum: A Case Report and Review of Literature. | Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal tract accounting for less than 1% of all gut tumors. GISTs occurring in the rectum are extremely rare and these usually present at an advanced stage compared with other sites. We report a case of a middle-aged female who presented with feat... | 10.1055/s-0042-1742778 | 35,187,230 | Surgery journal (New York, N.Y.) | 2,022 | ||
Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression. | The complex interplay between malignant cells and the cellular and molecular components of the tumor stroma is a key aspect of cancer growth and development. These tumor-host interactions are often affected by soluble bioactive molecules such as proteoglycans. Decorin, an archetypical small leucine-rich proteoglycan pr... | 10.1101/2023.08.28.555187 | 37,693,608 | bioRxiv : the preprint server for biology | 2,023 | ||
[Predictors of postoperative complications in patients with ventral hernia]. | OBJECTIVE
To evaluate potential predictors of 1-month postoperative complications after primary ventral hernia repair using database of the 1st Clinic of the Samarkand State Medical University.
MATERIAL AND METHODS
A cohort study included 348 patients who underwent ventral hernia surgery in the 1st Clinic of the Sama... | 10.17116/hirurgia202301156 | 36,583,494 | D006801:Humans; D015331:Cohort Studies; D006555:Hernia, Ventral; D011183:Postoperative Complications; D012307:Risk Factors; D059685:Herniorrhaphy; D012189:Retrospective Studies | Khirurgiia | 2,023 | |
[Meat inspection in the medieval Zähringer towns.]. | An explanation of medieval practices of meat supply and regulation, using examples drawn from the so-called "Zähringer towns" founded by the Dukes of Zähringen: Bern, Burgdorf, Thun, Murten, Freiburg and Rheinfelden. For the town councils it was important to be able to provide the population with sufficient quantities ... | 10.1024/0036-7281.a000004 | 20,033,872 | D000003:Abattoirs; D000818:Animals; D006041:Goats; D006920:Hygiene; D008460:Meat; D034421:Sus scrofa | Schweizer Archiv fur Tierheilkunde | 2,010 | |
Growth of aligned MWNT arrays using a micrometer scale local-heater at low ambient temperature. | Ambient room temperature growth of aligned multi-walled carbon nanotube arrays on micrometer scale local heaters is demonstrated. High growth rates of up to 8.8 microm per second have been achieved and the growth has been monitored in situ using optical microscopy. The growth starts and ends abruptly over the length of... | 10.1166/jnn.2010.1994 | 20,355,407 | Journal of nanoscience and nanotechnology | 2,010 | ||
The status of dermatoglyphics as a biomarker of Tel Hashomer camptodactyly syndrome: a review of the literature. | INTRODUCTION
Tel Hashomer camptodactyly syndrome is a rare disease and only a few cases have been reported. Dermatoglyphics potentially provide relevant phenotypic biomarkers that were initially noted as a vital clinical feature of this disease. Dermatoglyphics possibly can indicate growth disturbances that took place ... | 10.1186/s13256-016-1048-7 | 27,650,795 | D000015:Abnormalities, Multiple; D015415:Biomarkers; D001848:Bone Diseases, Developmental; D003878:Dermatoglyphics; D005385:Fingers; D006228:Hand Deformities, Congenital; D006344:Heart Septal Defects, Atrial; D006628:Hirsutism; D006801:Humans; D009135:Muscular Diseases | Journal of medical case reports | 2,016 | D015415:Biomarkers |
[Regional blood flow in splanchnic organs during positive end-expiratory pressure ventilation (author's transl)]. | An experimental study was performed on 10 dogs to evaluate the effect of positive end-expiratory pressure ventilation (PEEP) on hemodynamics and regional blood flow (RBF). The following conclusions can be drawn from the results of this study: 1) PEEP leads to a significant reduction of cardiac output (CO). 2) Total blo... | 6,993,125 | D000818:Animals; D004064:Digestive System; D004285:Dogs; D006439:Hemodynamics; D008102:Liver Circulation; D011175:Positive-Pressure Respiration | Chirurgisches Forum fur experimentelle und klinische Forschung | 1,980 | ||
Imiquimod treatment effectively reduces the percentage of viable cells in a cervical carcinoma cell line but does not affect the expression of HLA-G or OCT-4. | OBJECTIVE
Cervical cancer is a challenging pathologic entity because of its lack of response to conventional chemotherapy. Imiquimod is a synthetic analogue which seems to activate skin immune cells, acting as a Toll-like receptor 7 agonist. Previous studies in the field of cervical cancer have showed that its applicat... | 27,144,826 | D000634:Aminoquinolines; D002470:Cell Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D059951:HLA-G Antigens; D006367:HeLa Cells; D006801:Humans; D000077271:Imiquimod; D050814:Octamer Transcription Factor-3; D051199:Toll-Like Receptor 7; D002583:Uterine Cervical Neoplasms | Journal of stem cells | 2,015 | D000634:Aminoquinolines; D059951:HLA-G Antigens; D050814:Octamer Transcription Factor-3; C495348:TLR7 protein, human; D051199:Toll-Like Receptor 7; D000077271:Imiquimod |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.