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The criteria for metabolic syndrome and the national health screening and education system in Japan. | Two major definitions of metabolic syndrome have been proposed. One focuses on the accumulation of risk factors, a measure used by the American Heart Association (AHA) and the National Heart, Lung, and Blood Institute (NHLBI); the other focuses on abdominal obesity, a measure used by the International Diabetes Federati... | 10.4178/epih.e2017003 | 28,092,931 | D006266:Health Education; D006801:Humans; D007564:Japan; D008403:Mass Screening; D024821:Metabolic Syndrome; D056128:Obesity, Abdominal; D012016:Reference Values; D012307:Risk Factors; D055105:Waist Circumference | Epidemiology and health | 2,017 | |
[Preoperative localization of parathyroid adenomas using Tc-99m-sestamibi]. | Over an eight month period, ten patients with primary hyperparathyroidism were preoperatively scanned with Tc-99m-Sestamibi in order to locate adenomas. An adenoma was detected in nine patients, of which four were operated and good concordance was found between the scanning and the operative findings. Of the remaining ... | 8,650,759 | D000236:Adenoma; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism; D008297:Male; D008875:Middle Aged; D010282:Parathyroid Neoplasms; D016105:Parathyroidectomy; D011300:Preoperative Care; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D017256:Technetium Tc 99m Sestam... | Ugeskrift for laeger | 1,996 | D017256:Technetium Tc 99m Sestamibi | |
p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs. | To look for regulators of the mitogen-activated protein kinase (MAPK) kinase 6 (MKK6), a yeast two-hybrid screen was initiated using MKK6 as bait. p150(Glued) dynactin, a key component of the cytoplasmic dynein-dynactin motor complex, was found to specifically interact with MKK6 and its close homologue MKK3. Silencing ... | 10.1074/jbc.C400333200 | 15,375,157 | D000072159:Dynactin Complex; D004398:Dyneins; D004789:Enzyme Activation; D006367:HeLa Cells; D006801:Humans; D048371:MAP Kinase Kinase 3; D048669:MAP Kinase Kinase 6; D008869:Microtubule-Associated Proteins; D008870:Microtubules; D010766:Phosphorylation; D048051:p38 Mitogen-Activated Protein Kinases | The Journal of biological chemistry | 2,004 | C000606360:DCTN1 protein, human; D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins; D048051:p38 Mitogen-Activated Protein Kinases; D048371:MAP Kinase Kinase 3; D048669:MAP Kinase Kinase 6; C482530:MAP2K3 protein, human; C482566:MAP2K6 protein, human; D004398:Dyneins |
Optical imaging combined with targeted electrical recordings, microstimulation, or tracer injections. | To facilitate the combination of optical imaging with various electrode-based techniques, we have designed and produced a skull-mounting "sliding-top cranial window" and a removable "electrode positioner microdrive". These new devices were used to study sensory processing in chronic and acute experiments in the cerebra... | 10.1016/s0165-0270(02)00022-5 | 12,007,980 | D000200:Action Potentials; D000818:Animals; D001931:Brain Mapping; D002415:Cats; D004396:Coloring Agents; D004558:Electric Stimulation; D004566:Electrodes; D004594:Electrophysiology; D000882:Haplorhini; D008845:Microinjections; D008846:Micromanipulation; D009039:Motion Perception; D009474:Neurons; D014793:Visual Cortex | Journal of neuroscience methods | 2,002 | D004396:Coloring Agents |
Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging. | Preservation of mitochondrial function, which is dependent on mitochondrial homeostasis (biogenesis, dynamics, disposal/recycling), is critical for maintenance of skeletal muscle function. Skeletal muscle performance declines upon aging (sarcopenia) and is accompanied by decreased mitochondrial function in fast-glycoly... | 10.18632/aging.101643 | 30,449,736 | D000375:Aging; D000818:Animals; D004272:DNA, Mitochondrial; D006706:Homeostasis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008931:Mitochondria, Muscle; D018485:Muscle Fibers, Skeletal; D018482:Muscle, Skeletal; D009154:Mutation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010101:Oxygen Consum... | Aging | 2,018 | D004272:DNA, Mitochondrial |
The barley transcription factor HvMYB1 is a positive regulator of drought tolerance. | Transcription factors such as MYB have previously been associated with the plant response to drought. In this work, studies on the function of the barley (Hordeum vulgare L.) transcription factor HvMYB1 show that gene expression is upregulated in wildtype barley roots and leaves under drought and osmotic stress. Transg... | 10.1016/j.plaphy.2019.07.014 | 31,374,377 | D000040:Abscisic Acid; D003681:Dehydration; D018506:Gene Expression Regulation, Plant; D001467:Hordeum; D010937:Plant Growth Regulators; D010940:Plant Proteins; D018526:Plant Transpiration; D030821:Plants, Genetically Modified; D014157:Transcription Factors | Plant physiology and biochemistry : PPB | 2,019 | D010937:Plant Growth Regulators; D010940:Plant Proteins; D014157:Transcription Factors; D000040:Abscisic Acid |
The effects of race and insurance on potentially avoidable hospitalizations in Tennessee. | This study examined effects of race and insurance on the risk of potentially avoidable hospitalizations (PAHs) in Tennessee. Applying the current Agency for Healthcare Research and Quality definitions for ambulatory-care-sensitive conditions to inpatient discharge data, the study found hospitalized Black patients more ... | 10.1177/1077558708318283 | 18,490,268 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D006760:Hospitalization; D006801:Humans; D019458:Insurance Coverage; D007348:Insurance, Health; D008875:Middle Aged; D044469:Racial Groups; D013714:Tennessee | Medical care research and review : MCRR | 2,008 | |
Long-term vegetarian diet and bone mineral density in postmenopausal Taiwanese women. | This study examined bone density among postmenopausal Buddhist nuns and female religious followers of Buddhism in southern Taiwan and related the measurements to subjects characteristics including age, body mass, physical activity, nutrient intake, and vegetarian practice. A total of 258 postmenopausal Taiwanese vegeta... | 10.1007/pl00005812 | 9,069,160 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D015519:Bone Density; D001851:Bone Diseases, Metabolic; D014676:Diet, Vegetarian; D005260:Female; D005269:Femur; D006801:Humans; D008159:Lumbar Vertebrae; D008875:Middle Aged; D016017:Odds Ratio; D010024:Osteoporosis; D017698:Postmenopause; ... | Calcified tissue international | 1,997 | |
Tumoral Neuroligin 1 Promotes Cancer-Nerve Interactions and Synergizes with the Glial Cell Line-Derived Neurotrophic Factor. | Many nervous proteins are expressed in cancer cells. In this report, we asked whether the synaptic protein neuroligin 1 (NLGN1) was expressed by prostatic and pancreatic carcinomas; in addition, given the tendency of these tumors to interact with nerves, we asked whether NLGN1 played a role in this process. Through imm... | 10.3390/cells11020280 | 35,053,395 | D051339:Actin Depolymerizing Factors; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal; D045744:Cell Line, Tumor; D002465:Cell Movement; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D008810:Mice, Inbred C57BL; D009361:Neoplasm Invasiveness... | Cells | 2,022 | D051339:Actin Depolymerizing Factors; D015816:Cell Adhesion Molecules, Neuronal; C494988:Gfra1 protein, mouse; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; C093438:neuroligin 1 |
[Clinical changes in the oral cavity resulting from smokeless tobacco (Maraş powder)]. | OBJECTIVES
Maraş powder (MP) is a kind of smokeless tobacco prepared by a mixture of ash and the powder obtained from the leaves of a tobacco plant called "deli tütün" in the region. In this study, we investigated the physical changes occurring in the oral cavity of MP users.
PATIENTS AND METHODS
A total of 92 subjec... | 16,055,985 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002273:Carcinogens; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases; D009061:Mouth Mucosa; D010947:Plants, Toxic; D014030:Tobacco, Smokeless | Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat | 2,004 | D002273:Carcinogens | |
Microindentation of the young porcine ocular lens. | Debate regarding the mechanisms of how the eye changes focus (accommodation) and why this ability is lost with age (presbyopia) has recently been rejoined due to the advent of surgical procedures for the correction of presbyopia. Due to inherent confounding factors in both in vivo and in vitro measurement techniques, m... | 10.1115/1.3072891 | 19,275,444 | D000818:Animals; D001696:Biomechanical Phenomena; D055119:Elastic Modulus; D004548:Elasticity; D007907:Lens Nucleus, Crystalline; D007908:Lens, Crystalline; D008954:Models, Biological; D055095:Optics and Photonics; D012044:Regression Analysis; D033081:Shear Strength; D013314:Stress, Mechanical; D013552:Swine; D014783:V... | Journal of biomechanical engineering | 2,009 | |
Framed curves and knotted DNA. | The present mini-review covers the local and global geometry of framed curves and the computation of twist and writhe in knotted DNA circles. Classical inequalities relating the total amount of bending of a closed space curve and associated knot parameters are also explained. | 10.1042/BST20120346 | 23,514,168 | D000818:Animals; D004247:DNA; D006801:Humans; D008958:Models, Molecular; D009690:Nucleic Acid Conformation | Biochemical Society transactions | 2,013 | D004247:DNA |
ADHD - the scourge of the 21st century? | Currently, attention deficit hyperactivity disorder (ADHD) is intensively studied by world medical community, its understanding expands, for example, it has now been diagnosed not only in children but also in adults. On the other hand, ADHD raises a number of discussions on the need of its treatment and, if there is a ... | 10.12740/PP/67111 | 29,975,368 | D000328:Adult; D001007:Anxiety; D001008:Anxiety Disorders; D001289:Attention Deficit Disorder with Hyperactivity; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008603:Mental Health; D012720:Severity of Illness Index | Psychiatria polska | 2,018 | |
Transformed bone marrow cells generate neoplasms of distinct histogenesis. a murine model of cancer transplantation. | The last several years have witnessed renewed interest regarding the contribution of cancer stem cells in tumorigenesis and neoplastic heterogeneity. It has been reported that patients who undergo bone marrow transplantation are more prone to develop a malignancy during their life time; usually hematological tumors, bu... | 10.1016/j.scr.2019.101637 | 31,731,181 | D000818:Animals; D001854:Bone Marrow Cells; D002471:Cell Transformation, Neoplastic; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D014185:Transplantation, Isogeneic; D016159:Tumor Suppressor Protein p53 | Stem cell research | 2,019 | C000628667:Trp53 protein, mouse; D016159:Tumor Suppressor Protein p53 |
Lipid peroxidation is increased in paraoxonase L55 homozygotes compared with M-allele carriers. | Human serum paraoxonase (PON) is an antioxidative enzyme, which circulates on high-density lipoproteins and appears to use oxidized phospholipids as physiological substrates. PON M/L55 substitution changes the ability of PON to prevent lipid oxidation. Urinary 8-iso-PGF(2alpha) (one of F2 -isoprostanes) may represent a... | 10.1080/10715760100300421 | 11,378,531 | D043303:Aryldialkylphosphatase; D001205:Ascorbic Acid; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2; D015237:Dinoprost; D004950:Esterases; D028441:F2-Isoprostanes; D005260:Female; D005919:Glomerular Filtration Rate; D006720:Homozygote; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875... | Free radical research | 2,001 | D028441:F2-Isoprostanes; C075750:8-epi-prostaglandin F2alpha; C087337:6-S-hexadecyl-2-methoxythioascorbic acid; D015237:Dinoprost; D004950:Esterases; D043303:Aryldialkylphosphatase; D001205:Ascorbic Acid |
Cine MR imaging in mitral regurgitation: comparison with color Doppler flow imaging. | Cine MR imaging is a new technique that combines short repetition times, limited flip angles, gradient-refocused echoes, and cardiac gating. This procedure was performed in 20 patients in whom mitral regurgitation was shown on left ventriculography, and the results were compared with those of color Doppler flow mapping... | 10.2214/ajr.153.4.721 | 2,672,731 | D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency; D014463:Ultrasonography | AJR. American journal of roentgenology | 1,989 | |
Humanbecoming theory in practice: a case for theory-guided nurse practitioner education. | The age-old battle of what to include in nursing education continues. Now this battle extends itself into nurse practitioner education with a slightly different twist. Abandoning nursing theory-guided education for the medical model leaves nurse practitioner education flat. In this author's academic experience, nursing... | 10.1177/0894318412437957 | 22,451,631 | D006808:Humanism; D006801:Humans; D009722:Nurse Practitioners; D015402:Nursing Education Research; D009742:Nursing Theory | Nursing science quarterly | 2,012 | |
The Prevalence and Characteristics of Chronic Ankle Instability in Elite Athletes of Different Sports: A Cross-Sectional Study. | BACKGROUND
Ankle sprains are one of the most common injuries in athletic populations. Misdiagnosed and untreated ankle sprains will cause chronic ankle instability (CAI), which can significantly affect the performance of athletes. This study aimed to investigate the prevalence and characteristics of CAI in elite athlet... | 10.3390/jcm11247478 | 36,556,094 | Journal of clinical medicine | 2,022 | ||
Dexmedetomidine reduced the severity of emergence delirium and respiratory complications, but increased intraoperative hypotension in children underwent tonsillectomy. A retrospective analysis. | BACKGROUND
Intraoperative dexmedetomidine can be useful for its sedative and analgesic sparing effects, and for the prevention of emergence delirium. Conversely, it can cause hypotension and bradycardia. The aim of this study was to assess the safety and efficacy of dexmedetomidine in pediatric anesthesia.
METHODS
Th... | 10.23736/S2724-5276.21.06330-8 | 34,515,441 | Minerva pediatrics | 2,021 | ||
Activation of Ca(2+)-dependent currents in cultured rat dorsal root ganglion neurones by a sperm factor and cyclic ADP-ribose. | The effects of intracellular application of two novel Ca2+ releasing agents have been studied in cultured rat dorsal root ganglion (DRG) neurones by monitoring Ca(2+)-dependent currents as a physiological index of raised free cytosolic Ca2+ ([Ca2+]i). A protein based sperm factor (SF) extracted from mammalian sperm, ha... | 10.1091/mbc.3.12.1415 | 1,283,541 | D000246:Adenosine Diphosphate Ribose; D000818:Animals; D000831:Animals, Newborn; D001464:Barium; D002110:Caffeine; D002118:Calcium; D015220:Calcium Channels; D002478:Cells, Cultured; D006224:Cricetinae; D036563:Cyclic ADP-Ribose; D005727:Ganglia, Spinal; D008297:Male; D008564:Membrane Potentials; D009474:Neurons; D0115... | Molecular biology of the cell | 1,992 | D015220:Calcium Channels; D011506:Proteins; D014020:Tissue Extracts; D012430:Ruthenium Red; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D001464:Barium; D002110:Caffeine; D002118:Calcium |
Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases. | Dendritic cells (DCs) are targets of measles virus (MV) and play central roles in viral dissemination. However, DCs express the RIG-I-like receptors (RLRs) RIG-I and Mda5 that sense MV and induce type I interferon (IFN) production. Given the potency of this antiviral response, RLRs are tightly regulated at various step... | 25,011,106 | D015815:Cell Adhesion Molecules; D002460:Cell Line; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D003713:Dendritic Cells; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D037181:Lectins, C-Type; D008459:Measles virus; D054645:Protein Phosphatase 1; D011956:Receptors, Cell ... | Cell host & microbe | 2,014 | D015815:Cell Adhesion Molecules; C405948:DC-specific ICAM-3 grabbing nonintegrin; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D054645:Protein Phosphatase 1; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases | |
Assessment of headache characteristics in a general adolescent population: a comparison between retrospective interviews and prospective diary recordings. | BACKGROUND
Reliable information on headache characteristics, including frequency and intensity, headache-associated impairment, and use of analgesic medications, may depend on the assessment method used. This study analyzed the correlations between headache characteristics determined in structured interviews and those ... | 10.1186/s10194-016-0602-4 | 26,910,064 | D000293:Adolescent; D003430:Cross-Sectional Studies; D003943:Diagnostic Techniques, Neurological; D005260:Female; D006261:Headache; D006801:Humans; D008297:Male | The journal of headache and pain | 2,016 | |
MRI-BASED PROSTATE BRACHYTHERAPY SEED LOCALIZATION. | A magnetic resonance imaging (MRI) pulse sequence and a corresponding image processing algorithm to localize prostate brachytherapy seeds during or after therapy are presented. Inversion-Recovery with ON-resonant water suppression (IRON) is an MRI methodology that generates positive contrast in regions of magnetic fiel... | 10.1109/ISBI.2010.5490259 | 21,151,846 | Proceedings. IEEE International Symposium on Biomedical Imaging | 2,010 | ||
Healthy Body Image Intervention Delivered to Young Women via Facebook Groups: Formative Study of Engagement and Acceptability. | BACKGROUND
There is increasing interest in using social media sites such as Facebook to deliver health interventions so as to expose people to content while they are engaging in their usual social media habit. This formative intervention development study is novel in describing a preliminary test of using the secret gr... | 10.2196/resprot.9429 | 29,463,495 | JMIR research protocols | 2,018 | ||
Production and Perception of Intentional and Unintentional Actions. | Physical approach to biological movement is based on the idea of control with referent spatial coordinates for effectors, from the whole body to single muscles. Within this framework, neural control signals induce changes in parameters of corresponding biology-specific laws of nature, and motor performance emerges as a... | 10.2478/hukin-2020-0086 | 33,603,924 | Journal of human kinetics | 2,021 | ||
'There are people like me who will see that, and it will just wash over them': Black sexual minority men's perspectives on messaging in PrEP visual advertisements. | The high incidence of HIV among US Black sexual minority men is a public health crisis that pre-exposure prophylaxis (PrEP) for HIV can help address. Public health campaigns, which often include pictures of Black sexual minority men alongside PrEP-related messaging, have been developed to encourage PrEP awareness and u... | 10.1080/13691058.2022.2157491 | 36,598,172 | D006801:Humans; D008297:Male; D000329:Advertising; D001741:Black or African American; D015658:HIV Infections; D018451:Homosexuality, Male; D065129:Pre-Exposure Prophylaxis; D000072339:Sexual and Gender Minorities | Culture, health & sexuality | 2,023 | |
[Occurrence of rotavirus RNA electropherotypes in the pediatric population in Slovakia]. | Using the method of electrophoresis in polyacrylamide gel (PAGE), the authors assessed electropherotypes of rotavirus RNA in extracts of 119 specimens of faeces of sick children and from neonates with asymptomatic rotavirus infection. In both investigated groups they detected electropherotypes of five profiles: of thes... | 1,964,631 | D002648:Child; D003604:Czechoslovakia; D004591:Electrophoresis, Polyacrylamide Gel; D005759:Gastroenteritis; D006801:Humans; D007231:Infant, Newborn; D012367:RNA, Viral; D012401:Rotavirus | Ceskoslovenska epidemiologie, mikrobiologie, imunologie | 1,990 | D012367:RNA, Viral | |
Ca(2+)-dependent association of S100A6 (Calcyclin) with the plasma membrane and the nuclear envelope. | Expression of S100A6 (Calcyclin), a member of the S100 family and of Zn(2+)-binding proteins is elevated in a number of malignant tumors. In vitro the protein associates with several actin-binding proteins and annexins in a Ca(2+)-dependent manner. We have now studied the subcellular localization of S100A6 using a new,... | 10.1074/jbc.274.44.31593 | 10,531,365 | D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D002118:Calcium; D002451:Cell Compartmentation; D018797:Cell Cycle Proteins; D002455:Cell Division; D002458:Cell Fractionation; D002462:Cell Membrane; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D016253:Microscopy, ... | The Journal of biological chemistry | 1,999 | D000911:Antibodies, Monoclonal; D018797:Cell Cycle Proteins; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins; C055351:S100A6 protein, human; D002118:Calcium |
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells. | Hematopoietic stem cells (HSCs) are able to self-renew and to differentiate into all blood cells. HSCs reside in a low-perfusion niche and depend on local signals to survive and to maintain the capacity for self-renewal. HSCs removed from the niche are unable to survive without addition of hematopoietic cytokines and r... | 10.1371/journal.pone.0177054 | 28,486,555 | D001343:Autophagy; D006412:Hematopoietic Stem Cells; D006801:Humans; D015398:Signal Transduction | PloS one | 2,017 | |
A simulation study comparing the impact of experimental error on the performance of experimental designs and artificial neural networks used for process screening. | Many variables and their interactions can affect a biotechnological process. Testing a large number of variables and all their possible interactions is a cumbersome task and its cost can be prohibitive. Several screening strategies, with a relatively low number of experiments, can be used to find which variables have t... | 10.1007/s10295-004-0171-4 | 15,480,940 | D003470:Culture Media; D016014:Linear Models; D016571:Neural Networks, Computer; D012107:Research Design; D012441:Saccharomyces cerevisiae | Journal of industrial microbiology & biotechnology | 2,004 | D003470:Culture Media |
Tumor necrosis factor -308 and lymphotoxin +252 polymorphisms in Mexican children with Kawasaki disease and coronary aneurysms. | BACKGROUND AND AIMS
The Mexican population has a distinct capacity for the expression of tumor necrosis factor (TNF), a cytokine that plays a cardinal role in Kawasaki disease (KD), particularly in those who develop coronary aneurysms. It is important to identify, in Mexican pediatric patients, the association of the f... | 10.1016/j.arcmed.2011.11.002 | 22,100,609 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm; D003430:Cross-Sectional Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008233:Lymphotoxin-alpha; D008800:Mexico; D009080:Mucocutaneous Lymph Node Syndrome; D016133:Polymerase Chain Reaction; D011110:Polymorphism,... | Archives of medical research | 2,011 | D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha |
[Target syndromes and reaction spectra of psychopharmaceuticals. Problems in therapy and research]. | Experiments were held not only to determine clinical differences in reaction for neuroleptics and antidepressants, but also to place them in relation to pharmacological data gained from animal experiments. For the tranquilizers, only a scheme of clinical impressions, could be offered since with this group of psychotrop... | 829,606 | D000818:Animals; D001143:Arousal; D002375:Catalepsy; D002415:Cats; D003863:Depression; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006212:Hallucinations; D006801:Humans; D010259:Paranoid Disorders; D011595:Psychomotor Agitation; D011600:Psychopharmacology; D... | Psychiatrie, Neurologie und medizinische Psychologie. Beihefte | 1,975 | D011619:Psychotropic Drugs | |
Isolation and partial characterization of canine epidermal growth factor/urogastrone. | Canine epidermal growth factor (EGF)/urogastrone was partially purified from dog urine by fractional precipitation with (NH4)2SO4, ion-exchange chromatography with DEAE-cellulose DE-52, gel filtration with Sephadex G-50, and a second DE-52 chromatography, to yield receptor-competing activity equivalent to 13 micrograms... | 10.1042/bj2290611 | 3,876,829 | D000596:Amino Acids; D000818:Animals; D002460:Cell Line; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D004247:DNA; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel; D004815:Epidermal Growth Factor; D010446:Peptide Fragments; D011869:Radioligand Assay | The Biochemical journal | 1,985 | D000596:Amino Acids; D010446:Peptide Fragments; D004815:Epidermal Growth Factor; D004247:DNA |
Effect of nitrogen source and nitrogen concentration on the production of pyruvate by Torulopsis glabrata. | The effect of nitrogen sources including yeast extract, peptone, soybean hydrolyzate and some inorganic nitrogen sources, as well as the nitrogen concentration on the fermentative production of pyruvate by Torulopsis glabrata WSH-IP12 was investigated. The addition of yeast extract greatly inhibited pyruvate accumulati... | 10.1016/s0168-1656(00)00273-x | 10,936,657 | D002175:Candida; D002244:Carbon; D005285:Fermentation; D006868:Hydrolysis; D009584:Nitrogen; D010461:Peptones; D019289:Pyruvic Acid; D013025:Glycine max; D015003:Yeasts | Journal of biotechnology | 2,000 | D010461:Peptones; D002244:Carbon; D019289:Pyruvic Acid; D009584:Nitrogen |
Portal hypertension and variceal hemorrhage. | Portal hypertension, a major hallmark of cirrhosis, is defined as a portal pressure gradient exceeding 5 mm Hg. In portal hypertension, porto-systemic collaterals decompress the portal circulation and give rise to varices. Successful management of portal hypertension and its complications requires knowledge of the unde... | 10.1016/j.mcna.2007.12.003 | 18,387,376 | D003097:Collateral Circulation; D004108:Dilatation, Pathologic; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices; D006471:Gastrointestinal Hemorrhage; D006490:Hemostatics; D006801:Humans; D006975:Hypertension, Portal; D008026:Ligation; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D... | The Medical clinics of North America | 2,008 | D006490:Hemostatics; D014667:Vasopressins |
Cytotoxic activity of 7-N-(2-((2-(-gamma-L-glutamylamino)- ethyl)dithio)ethyl)-mitomycin C and metabolites in cell lines with different resistance patterns. | In this study the activity of KW-2149 and two of its metabolites, M-16 and M-18, was measured against cell lines with different types of resistance. The influence of these metabolites and of the exposure time on the cytotoxic efficacy of KW-2149 was investigated. Against the human ovarian carcinoma cell lines, AOvC and... | 10.1097/00001813-199406000-00013 | 7,919,460 | D000818:Animals; D003110:Colonic Neoplasms; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007700:Kinetics; D016685:Mitomycin; D008937:Mitomycins; D010051:Ovarian Neoplasms; D051381:Rats; D014407:Tumor Cells, Cultured | Anti-cancer drugs | 1,994 | D008937:Mitomycins; C057625:KW 2149; D016685:Mitomycin |
Plant microtubule inhibitors against trypanosomatids. | Trypanosomatid protozoa are etiologic agents of several prevalent tropical diseases. Tubulins constitute 10% of the total proteins of these organisms. In addition, they are conserved within the Trypanosomatidae family but are different from that of the mammalian hosts. Since current chemotherapy has severe side effects... | 10.1016/0169-4758(94)90182-1 | 15,275,534 | Parasitology today (Personal ed.) | 1,994 | ||
Effects of trace elements on albumin and lipoprotein glycation in diabetic retinopathy. | OBJECTIVE
To test the effect of some trace elements, on protein and lipoprotein glycosylation and their impact on the severity of diabetic retinopathy.
METHODS
A case control study was conducted in 42 diabetic patients (14 without retinopathy [DC]; 14 with non-proliferative diabetic retinopathy [NPDR]; 14 with prolif... | 19,838,431 | D002104:Cadmium; D002857:Chromium; D003300:Copper; D003930:Diabetic Retinopathy; D018450:Disease Progression; D006031:Glycosylation; D006801:Humans; D007493:Iraq; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D018384:Oxidative Stress; D012016:Reference Values; D012643:Selenium; D012709:Serum Albumin; D014131:Trace E... | Saudi medical journal | 2,009 | D008074:Lipoproteins; D008077:Lipoproteins, LDL; D012709:Serum Albumin; D014131:Trace Elements; D002104:Cadmium; D002857:Chromium; D003300:Copper; D012643:Selenium; D015032:Zinc | |
Propagation of tears in pericardium from young bulls: influence of the suture. | The tearing of the collagen fibers of biological materials utilized in implants or bioprostheses is an important, and sometimes early cause of the failure of these devices. We studied the force necessary to propagate a tear in a biomaterial, pericardium from young bulls, and the influence of the suture. An Elmendorf pe... | 10.1111/j.1525-1594.2009.00943.x | 20,447,036 | D000367:Age Factors; D000818:Animals; D001705:Bioprosthesis; D006348:Cardiac Surgical Procedures; D002417:Cattle; D019544:Equipment Failure Analysis; D008297:Male; D008422:Materials Testing; D008954:Models, Biological; D009757:Nylons; D010496:Pericardium; D011126:Polypropylenes; D011474:Prosthesis Design; D011475:Prost... | Artificial organs | 2,010 | D009757:Nylons; D011126:Polypropylenes |
[Detection of firmness and surface color of pear by near infrared spectroscopy based on Monte Carlo uninformative variables elimination method]. | In the present study, NIRS was applied to nondestructive and rapid measurement of firmness and surface color of pear. In order to improve the prediction precision and eliminate the influence of uninformative variables on model robustness, Monte Carlo uninformative variables elimination (MC-UVE) and Monte Carlo uninform... | 21,800,570 | D002138:Calibration; D005504:Food Analysis; D005638:Fruit; D008962:Models, Theoretical; D009010:Monte Carlo Method; D031989:Pyrus; D019265:Spectroscopy, Near-Infrared | Guang pu xue yu guang pu fen xi = Guang pu | 2,011 | ||
A quantitative method for the specific assessment of caspase-6 activity in cell culture. | Aberrant activation of caspase-6 has recently emerged as a major contributor to the pathogeneses of neurodegenerative disorders such as Alzheimer's and Huntington disease. Commercially available assays to measure caspase-6 activity commonly use the VEID peptide as a substrate. However these methods are not well suited ... | 10.1371/journal.pone.0027680 | 22,140,457 | D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D053178:Caspase 6; D018929:Cell Culture Techniques; D002457:Cell Extracts; D002522:Chlorocebus aethiops; D057075:Enzyme Assays; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D007700:Kinetics; D034882:La... | PloS one | 2,011 | D002457:Cell Extracts; D034882:Lamins; D010455:Peptides; D053178:Caspase 6 |
Two-Dimensional X-Ray Angiography to Examine Fine Vascular Structure Using a Silicone Rubber Injection Compound. | Angiography is an essential tool for the study of vascular structures in various research fields. The aim of this study is to introduce a simple angiographic method for examining the fine vascular structure of unfixed, fresh tissue using a silicone rubber injection compound and soft tissue X-ray system. This study is e... | 10.3791/57732 | 30,663,660 | D000792:Angiography; D000818:Animals; D006801:Humans; D007267:Injections; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012408:Rubber; D012826:Silicone Elastomers; D014965:X-Rays | Journal of visualized experiments : JoVE | 2,019 | D012826:Silicone Elastomers; D012408:Rubber |
Pulmonary radiologic findings in common variable immunodeficiency: clinical and immunological correlations. | BACKGROUND
It remains unclear whether interstitial lung disease (ILD) in common variable immunodeficiency (CVID) is a consequence of chronic infection or a manifestation of dysregulated lymphoid proliferation found in those with this condition.
OBJECTIVE
To increase understanding of CVID-associated lung disease by co... | 24,880,814 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune; D001987:Bronchiectasis; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes; D017074:Common Variable Immunodeficiency; D057286:Electronic Health Records; D005260:Female;... | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology | 2,014 | D007075:Immunoglobulin M | |
Histologic Features Associated With Columnar-lined Esophagus in Distal Esophageal and Gastroesophageal Junction (GEJ) Biopsies From GERD Patients: A Community-based Population Study. | There are inherent problems with the endoscopic and pathologic criteria for columnar-lined esophagus (CLE). Furthermore, the clinical and biological significance of an irregular squamocolumnar junction (SCJ) is unclear. The aim of this study was to evaluate the association between histologic features in SCJ biopsies an... | 10.1097/PAS.0000000000000623 | 26,927,889 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus; D003430:Cross-Sectional Studies; D004847:Epithelial Cells; D000071041:Esophageal Mucosa; D004943:Esophagogastric Junction; D005260:Female; D005764:Gastroesophageal Reflux; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young ... | The American journal of surgical pathology | 2,016 | |
Immediate effect of myofascial release on range of motion, pain and biceps and rectus femoris muscle activity after total knee replacement. | OBJECTIVES
The role of a myofascial release (MFR) on flexion contractures after total knee arthroplasty (TKA) has not yet been elucidated. Therefore, the purpose of this study was to determine its immediate effect on such patients.
METHODS
In this A-B single subject experimental study, 33 TKA's patients with knee fle... | 10.1016/j.jbmt.2017.12.003 | 30,368,337 | D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D004576:Electromyography; D005205:Fascia; D005260:Female; D000070633:Hamstring Muscles; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain; D016059:Range of Motion, Articular; D064746:Therapy, Soft Tissue; D061028:Trigger Points | Journal of bodywork and movement therapies | 2,018 | |
Community structure of soft sediment pool fishes in Moreton Bay, Australia. | A survey of soft sediment tide pools was conducted to assess the occupation and assemblage of fishes on three different intertidal shores in Moreton Bay, Australia, between January and December 2009. Tide-pool volume ranged from 0· 30 to 29· 75 l and varied significantly between months and sites. A total of 1364 indivi... | 10.1111/j.1095-8649.2010.02866.x | 21,284,630 | D000818:Animals; D001315:Australia; D058448:Biota; D004463:Ecology; D005399:Fishes; D012621:Seasons; D012623:Seawater | Journal of fish biology | 2,011 | |
Drug-Resistant Tuberculosis: A Glance at Progress and Global Challenges. | Multidrug-resistant Mycobacterium tuberculosis remains a major public health threat; its management poses a significant economic burden. Treatment requires a programmatic approach with access to laboratory services, second-line medications, and adequate clinical resources. In recent years, we have seen rapid developmen... | 10.1016/j.idc.2020.06.001 | 33,011,048 | D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D042241:Early Diagnosis; D016680:Genome, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009169:Mycobacterium tuberculosis; D018088:Tuberculosis, Multidrug-Resistant; D000073336:Whole Genome Sequencing | Infectious disease clinics of North America | 2,020 | D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents |
Fluid flow in distensible vessels. | 1. Flow in single vascular conduits is reviewed, divided into distended and deflated vessels. 2. In distended vessels with pulsatile flow, wave propagation and reflection dominate the spatial and temporal distribution of pressure, determining the shape, size and relative timing of measured pressure waveforms, as well a... | 10.1111/j.1440-1681.2008.05047.x | 18,785,981 | D001775:Blood Circulation; D001808:Blood Vessels; D001826:Body Fluids; D006801:Humans; D008954:Models, Biological; D010528:Peristalsis; D011673:Pulsatile Flow | Clinical and experimental pharmacology & physiology | 2,009 | |
Multiple phenotypic traits as triggers of host attacks towards ant symbionts: body size, morphological gestalt, and chemical mimicry accuracy. | BACKGROUND
Ant colonies are plagued by a diversity of arthropod guests, which adopt various strategies to avoid or to withstand host attacks. Chemical mimicry of host recognition cues is, for example, a common integration strategy of ant guests. The morphological gestalt and body size of ant guests have long been argue... | 10.1186/s12983-021-00427-8 | 34,538,256 | Frontiers in zoology | 2,021 | ||
Role of the Z band in the mechanical properties of the heart. | In striated muscle the mechanism of contraction involves the cooperative movement of contractile and elastic components. This review emphasizes a structural approach that describes the cellular and extracellular components with known anatomical, biochemical, and physical properties that make them candidates for these c... | 10.1096/fasebj.5.8.2022313 | 2,022,313 | D000818:Animals; D006321:Heart; D008954:Models, Biological; D009119:Muscle Contraction; D009126:Muscle Relaxation; D009132:Muscles; D009206:Myocardium; D051381:Rats | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 1,991 | |
A comparison of morphologic features, flow cytometry, TCR-Vbeta analysis, and TCR-PCR in qualitative and quantitative assessment of peripheral blood involvement by Sézary syndrome. | The strengths and weaknesses of various laboratory methods for peripheral blood (PB) Sézary cell quantitation have not been compared rigorously. In this study, manual Sézary cell counting, qualitative and quantitative flow cytometry, T-cell receptor (TCR) Vbeta flow cytometry, and TCR polymerase chain reaction were per... | 16,613,339 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005434:Flow Cytometry; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D016693:Receptors, Antigen, T-Cell, alpha-beta;... | American journal of clinical pathology | 2,006 | D016693:Receptors, Antigen, T-Cell, alpha-beta | |
Functional decline in cognitive impairment--the relationship between physical and cognitive function. | BACKGROUND
Physical function decline is associated with dementia, which might either be mediated by the coexisting sarcopenia or directly related to the impaired cognition. Our objectives are to examine the relationship between cognitive function and performance-based physical function and to test the hypothesis that c... | 10.1159/000154929 | 18,784,415 | D000368:Aged; D015519:Bone Density; D002681:China; D003071:Cognition; D003072:Cognition Disorders; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D018737:Hand Strength; D006299:Health Services for the Aged; D006306:Health Surveys; D006723:Hong Kong; D006801:Hum... | Neuroepidemiology | 2,008 | |
MicroRNA-29a: a novel target for non-operative management of symptomatic lumbar spinal stenosis. | PURPOSE
Lumbar spinal stenosis (LSS) is the most common reason for spinal surgery in patients over the age of 65, and there are few effective non-surgical treatments. Therefore, the development of novel treatment or preventative modalities to decrease overall cost and morbidity associated with LSS is an urgent matter. ... | 10.1007/s00586-023-07671-y | 37,046,075 | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society | 2,023 | ||
The intrapsychic and intersubjective in psychoanalysis. | Both the intrapsychic and the intersubjective take part in the analytic process. A pointless struggle for supremacy may await those who support either point of view exclusively. If the "objectal" perspective is well known, the "subjectal" one is less theoretically defined: it includes the series of the ego, the self, t... | 10.1002/j.2167-4086.2000.tb00553.x | 10,729,941 | D006801:Humans; D011574:Psychoanalytic Theory; D011575:Psychoanalytic Therapy | The Psychoanalytic quarterly | 2,000 | |
Effect of estrogen therapy on vascular perlecan and metalloproteinases 2 and 9 in castrated rats. | AIM
To study the effects of estrogen therapy on the expression of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) and perlecan in the vascular wall.
METHODS
Twenty 180-day-old Wistar rats were castrated and treated 1 week later for a period of 4 weeks with one of the following: (1) placebo; (2) 0.5 μg/day estradi... | 10.3109/13697137.2012.667173 | 22,640,525 | D000704:Analysis of Variance; D000818:Animals; D002339:Carotid Arteries; D004305:Dose-Response Relationship, Drug; D004958:Estradiol; D004967:Estrogens; D005260:Female; D015870:Gene Expression; D019812:Heparan Sulfate Proteoglycans; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D010052:Ovariec... | Climacteric : the journal of the International Menopause Society | 2,013 | D004967:Estrogens; D019812:Heparan Sulfate Proteoglycans; D012333:RNA, Messenger; C071927:perlecan; C074283:estradiol 3-benzoate; D004958:Estradiol; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9 |
Risk factors and haemodynamic variables in patients with low toe-brachial index but normal ankle-brachial index. | BACKGROUND AND AIMS
Classically, peripheral arterial disease (PAD) is diagnosed by a low ankle-brachial index (ABI), but the diagnosis can also be made based on toe-brachial index (TBI) measurements. The objective of this study was to characterize patients with low TBI but normal ABI, and chart potential underestimatio... | 10.1016/j.atherosclerosis.2019.08.005 | 31,446,210 | D000368:Aged; D055109:Ankle Brachial Index; D002309:Cardiology; D016022:Case-Control Studies; D015897:Comorbidity; D003718:Denmark; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease; D015995:Prevalence; D012307:Risk Factors; D016896:Treatment Ou... | Atherosclerosis | 2,019 | |
Long-term Survival and Quality of Life among Survivors Discharged from a Respiratory ICU in North India: A Prospective Study. | Background
Advancements in the intensive care unit (ICU) have improved critically ill subjects' short-term outcomes. However, there is a need to understand the long-term outcomes of these subjects. Herein, we study the long-term outcomes and factors associated with poor outcomes in critically ill subjects with medical ... | 10.5005/jp-journals-10071-24321 | 36,876,197 | Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine | 2,022 | ||
Perceived risks and benefits of smoking cessation: gender-specific predictors of motivation and treatment outcome. | The primary aim of this study was to examine gender differences in perceived risks and benefits of smoking cessation and their relationship to pretreatment motivation and treatment outcome. No validated measures that comprehensively assess perceived risks and benefits associated with smoking cessation were available in... | 10.1016/j.addbeh.2004.05.027 | 15,718,060 | D001294:Attitude to Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D009042:Motivation; D015999:Multivariate Analysis; D011594:Psychometrics; D015203:Reproducibility of Results; D012307:Risk Factors; D012647:Self-Assessment; D012737:Sex Factors; D016540:Smoking ... | Addictive behaviors | 2,005 | |
eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1. | The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C-θ (PKC-θ) at the ce... | 10.1371/journal.pbio.2000653 | 28,394,935 | D000199:Actins; D019943:Amino Acid Substitution; D002460:Cell Line; D002478:Cells, Cultured; D003545:Cysteine; D004789:Enzyme Activation; D006056:Golgi Apparatus; D006801:Humans; D054992:Immunological Synapses; D007527:Isoenzymes; D008164:Luminescent Proteins; D009154:Mutation; D009569:Nitric Oxide; D052250:Nitric Oxid... | PLoS biology | 2,017 | D000199:Actins; D007527:Isoenzymes; D008164:Luminescent Proteins; C495738:PFN1 protein, human; D051304:Profilins; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; C076233:PRKCQ protein, human; D011493:Protein Ki... |
Treatment duration affects cytoprotective efficacy of positive allosteric modulation of α7 nAChRs after focal ischemia in rats. | To minimize irreversible brain injury after acute ischemic stroke (AIS), the time to treatment (i.e., treatment delay) should be minimized. However, thus far, all cytoprotective clinical trials have failed. Analysis of literature identified short treatment durations (≤72 h) as a common motif among completed cytoprotect... | 10.1016/j.phrs.2018.09.001 | 30,205,140 | D000494:Allosteric Regulation; D000818:Animals; D001921:Brain; D004334:Drug Administration Schedule; D020244:Infarction, Middle Cerebral Artery; D007555:Isoxazoles; D008297:Male; D018696:Neuroprotective Agents; D018722:Nicotinic Agonists; D010671:Phenylurea Compounds; D017207:Rats, Sprague-Dawley; D064569:alpha7 Nicoti... | Pharmacological research | 2,018 | C508388:1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea; D007555:Isoxazoles; D018696:Neuroprotective Agents; D018722:Nicotinic Agonists; D010671:Phenylurea Compounds; D064569:alpha7 Nicotinic Acetylcholine Receptor |
Toxicity studies of 1,3-dichlorobenzene in Sprague-Dawley rats. | Male and female Sprague-Dawley rats received 1,3-dichlorobenzene daily by corn oil gavage for 10 or 90 consecutive days. The 10-day study doses were 0, 37, 147, 368 and 735 mg/kg; the 90-day study doses were 0, 9, 37, 147 and 588 mg/kg. In the 10-day study, there was a significant depression of body weight in both sexe... | 10.3109/01480549509014321 | 7,497,912 | D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D002722:Chlorobenzenes; D004326:Drinking; D004435:Eating; D005260:Female; D006403:Hematologic Tests; D008297:Male; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012015:Reference Standards; D012307:Risk F... | Drug and chemical toxicology | 1,995 | D002722:Chlorobenzenes; D014874:Water Pollutants, Chemical; C042146:1,3-dichlorobenzene |
Indirect pulp treatment vs antibiotic sterilization of deep caries in mandibular primary molars. | BACKGROUND
Calcium hydroxide indirect pulp treatment (CH-IPT) and antibiotic sterilization using a mixture of three antibiotics (3Mix-MP) of deep caries are similar non-invasive vital pulp treatments. No studies have compared their clinical and radiographic success rates in primary molars.
AIM
To compare the clinical... | 10.1111/ipd.12022 | 23,346,907 | D000900:Anti-Bacterial Agents; D002126:Calcium Hydroxide; D002648:Child; D002675:Child, Preschool; D003731:Dental Caries; D003789:Dental Pulp Exposure; D003793:Dental Restoration, Permanent; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible; D008963:Molar; D013242:Sterilization; D014094:Tooth, Deciduous; D... | International journal of paediatric dentistry | 2,014 | D000900:Anti-Bacterial Agents; D002126:Calcium Hydroxide |
Surgical treatment of hepatocellular cancer in the era of hepatic transplantation. | BACKGROUND
This study compares liver resection (LR) or transplantation (LTx) in an attempt to reevaluate the indications for treatment.
STUDY DESIGN
One hundred fifty-four LRs and 121 LTxs performed from 1985 to 1999 were considered. Survival and recurrence rate, together with age, gender, liver disease, Child-Pugh c... | 10.1016/S1072-7515(03)00140-6 | 12,788,425 | D000206:Actuarial Analysis; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D006528:Carcinoma, Hepatocellular; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms; D016031:Liver Transplantation; D008297:Male; D008875:Mid... | Journal of the American College of Surgeons | 2,003 | D000509:alpha-Fetoproteins |
[The socialization of medicine in the era of São Paulo Governor Adhemar de Barros]. | The article analyzes how the process of the professionalization of physicians in São Paulo related to healthcare policy under the administration of São Paulo governor Adhemar de Barros (1947-1951) during a period of broad change in the realm of health known by São Paulo physicians as the "socialization of medicine." Me... | 25,606,733 | D001938:Brazil; D006076:Government; D049673:History, 20th Century; D000068616:Professionalism; D012936:Social Medicine | Historia, ciencias, saude--Manguinhos | 2,014 | ||
Work-hour restrictions as an ethical dilemma for residents. | BACKGROUND
We propose that the standardized work-hour limitations have created an ethical dilemma for residents.
METHODS
A survey tool was designed to assess factors that influence the number of hours residents work and report. The program directors of pediatrics, internal medicine, and general surgery at our institu... | 10.1016/j.amjsurg.2006.01.002 | 16,531,148 | D016009:Chi-Square Distribution; D003663:Decision Trees; D004992:Ethics, Medical; D006801:Humans; D007396:Internship and Residency; D010561:Personnel Staffing and Scheduling; D011795:Surveys and Questionnaires; D014481:United States; D014940:Work Schedule Tolerance; D016526:Workload | American journal of surgery | 2,006 | |
Comparison of Esophageal Function Tests in Chinese Patients with Functional Heartburn and Reflux Hypersensitivity. | OBJECTIVE
To investigate the differences in the results of esophageal function tests for functional heartburn (FH) and reflux hypersensitivity (RH).
METHODS
Patients with FH and RH and healthy volunteers (HVs) from the Department of Gastroenterology, Beijing Anzhen Hospital and Beijing Chao-Yang hospital, who underwe... | 10.1155/2017/3596148 | 29,018,480 | Gastroenterology research and practice | 2,017 | ||
Clindamycin in the treatment of group G beta-haemolytic streptococcal infections. | We report a case of severe streptococcal cellulitis in a healthy 47 year old male, where the sole microbial isolate was a beta-haemolytic group G Streptococcus. Treatment failure with high dose penicillin was observed despite in vitro sensitivity. The addition of clindamycin resulted in dramatic clinical improvement. T... | 10.1016/j.jinf.2005.02.013 | 16,291,271 | D000038:Abscess; D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein; D002481:Cellulitis; D002981:Clindamycin; D004359:Drug Therapy, Combination; D004890:Erythema; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013290:Streptococcal Infections; D013291:Streptococcus; D016896:Treatment... | The Journal of infection | 2,005 | D000900:Anti-Bacterial Agents; D002981:Clindamycin; D002097:C-Reactive Protein |
[Clinical features of children with lysinuric protein intolerance and SLC7A7 gene mutation: an analysis of 3 cases]. | Lysinuric protein intolerance (LPI) is an autosomal recessive disorder caused by SLC7A7 gene mutation and often involves severe lesions in multiple systems. Lung involvement is frequently seen in children with LPI and such children tend to have a poor prognosis. This article summarizes the clinical manifestations and g... | 31,014,432 | D000592:Amino Acid Metabolism, Inborn Errors; D027241:Amino Acid Transport System y+L; D002648:Child; D002956:Citrulline; D027301:Fusion Regulatory Protein 1, Light Chains; D006801:Humans; D008239:Lysine; D009154:Mutation | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics | 2,019 | D027241:Amino Acid Transport System y+L; D027301:Fusion Regulatory Protein 1, Light Chains; C421261:SLC7A7 protein, human; D002956:Citrulline; D008239:Lysine | |
Fetal Umbilical Arterial Pulsatility Correlates With 2-Year Growth and Neurodevelopmental Outcomes in Congenital Heart Disease. | BACKGROUND
Children with congenital heart disease (CHD) are at risk of adverse long-term neurodevelopmental outcomes, believed to be, in part, secondary to prenatal insults. Placental pathology and altered fetal middle cerebral arterial (MCA) flow suggestive of brain sparing have been documented in fetal CHD. In the pr... | 10.1016/j.cjca.2020.06.024 | 32,653,583 | D002657:Child Development; D002675:Child, Preschool; D005260:Female; D005333:Fetus; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome; D008297:Male; D020768:Middle Cerebral Artery; D009048:Motor Skills; D065886:Neurodevelopmental Disorders; D009483:Neuropsychological Tests; D010927:Placental Insufficiency; D01124... | The Canadian journal of cardiology | 2,021 | |
Machine Learning Algorithm to Predict Acidemia Using Electronic Fetal Monitoring Recording Parameters. | BACKGROUND
Electronic fetal monitoring (EFM) is the universal method for the surveillance of fetal well-being in intrapartum. Our objective was to predict acidemia from fetal heart signal features using machine learning algorithms.
METHODS
A case-control 1:2 study was carried out compromising 378 infants, born in the... | 10.3390/e24010068 | 35,052,094 | Entropy (Basel, Switzerland) | 2,021 | ||
The Health Status of the US Veterans: A Longitudinal Analysis of Surveillance Data Prior to and during the COVID-19 Pandemic. | Chronic diseases affect a disproportionate number of United States (US) veterans, causing significant long-term health issues and affecting entitlement spending. This longitudinal study examined the health status of US veterans as compared to non-veterans pre- and post-COVID-19, utilizing the annual Center for Disease ... | 10.3390/healthcare11142049 | 37,510,490 | Healthcare (Basel, Switzerland) | 2,023 | ||
Straight-run vs. sex separate rearing for two broiler genetic lines Part 2: Economic analysis and processing advantages. | The objective of this analysis was to evaluate the effects of raising broilers under sex separate and straight-run conditions for 2 broiler genetic lines. One-day-old Ross 308 and Ross 708 chicks (n = 1,344) were sex separated and placed in 48 pens according to rearing type: sex separate (28 males or 28 females) or str... | 10.3382/ps/pew498 | 28,339,876 | D000821:Animal Feed; D000822:Animal Husbandry; D000818:Animals; D002645:Chickens; D004032:Diet; D005260:Female; D008297:Male | Poultry science | 2,017 | |
PAK4-relevant proliferation reduced by cell autophagy via p53/mTOR/p-AKT signaling. | Background
P21-activated kinase 4 (PAK4) involves in cell proliferation in cancer and mutually regulates with p53, a molecule is demonstrated to control cell autophagy by mammalian target of rapamycin (mTOR)/protein kinase B (AKT) signaling. Since the signaling exhibits an association with PAK family members in cell au... | 10.21037/tcr-22-2272 | 37,033,362 | Translational cancer research | 2,023 | ||
Fine assignment of beta-hexosaminidase A alpha-subunit on 15q23-q24 by high resolution in situ hybridization. | Tay-Sachs disease results from mutation in the gene encoding beta-hexosaminidase A alpha-subunit. Although some reports have suggested the locus on 15q, we tried to determine the finer gene locus using high resolution in situ hybridization. cDNA probe, p beta H alpha-5, containing the full-length sequence for the enzym... | 10.1620/tjem.160.203 | 2,141,199 | D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D004247:DNA; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D013661:Tay-Sachs Disease; D001619:beta-N-Acetylhexosaminidases | The Tohoku journal of experimental medicine | 1,990 | D004247:DNA; D001619:beta-N-Acetylhexosaminidases |
Cutaneous Tuberculosis Occurring After a Skin Cut in a Child. | BACKGROUND
Tuberculosis is a common problem in Turkey, and cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis. Herein, the authors describe a case of cutaneous tuberculosis (lupus vulgaris) occurring after contact with a sheep.
CASE
A 15-year-old boy was admitted to Marmara University School of Medi... | 27,560,476 | D000003:Abattoirs; D000293:Adolescent; D000818:Animals; D000995:Antitubercular Agents; D001365:Axilla; D004977:Ethambutol; D005383:Finger Injuries; D006801:Humans; D007538:Isoniazid; D008177:Lupus Vulgaris; D000072281:Lymphadenopathy; D008297:Male; D009169:Mycobacterium tuberculosis; D009784:Occupational Diseases; D011... | Wounds : a compendium of clinical research and practice | 2,016 | D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin | |
The effect of meperidine analgesia on midtrimester abortions induced with intra-amniotic prostaglandin F2alpha. | To determine whether increased amounts of meperidine significantly affect the induction of abortion with intra-amniotic prostaglandin F2alpha, 42 midtrimester subjects were treated with an identical dose schedule of PFG2alpha and one of two dose schedules of meperidine. Although the group that received more mepridine r... | 10.1016/0002-9378(76)90590-1 | 1,266,898 | D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D004716:Endometritis; D005260:Female; D006801:Humans; D008614:Meperidine; D010146:Pain; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F; D013997:Time Factors; D014590:Uterine Contraction; D014592:Uterine Hemorrhage | American journal of obstetrics and gynecology | 1,976 | D011460:Prostaglandins F; D008614:Meperidine |
Twisted-Planar-Twisted expanded porphyrinoid dimer as a rudimentary reaction-based methanol indicator. | Directly linked porphyrin dimers have attracted considerable attention because of their intriguing electronic features. Most emphasis has been placed on either dimers with large dihedral angles between the constituent planar monomeric subunits or those with overall planarity, referred to as "Planar-Twisted-Planar" and ... | 10.1038/s41467-020-19118-9 | 33,082,348 | Nature communications | 2,020 | ||
Methotrexate-induced germ cell toxicity and the important role of zinc and SOD1: Investigation of molecular mechanisms. | Zinc (Zn) was proved to be a germ cell protectant against various disease conditions and toxic insults. Besides other mechanisms, here we have explored the important role of Zn and Zn-dependent SOD1in methotrexate (MTX)-induced germ cell damage. MTX was given 5 mg/kg i.p. once a week for four consecutive weeks, while Z... | 10.1016/j.bbrc.2016.12.098 | 28,011,267 | D000818:Animals; D002374:Catalase; D004249:DNA Damage; D019587:Dietary Supplements; D004050:Ditiocarb; D004822:Epididymis; D005854:Germ Cells; D005979:Glutathione Peroxidase; D008297:Male; D008727:Methotrexate; D054778:NM23 Nucleoside Diphosphate Kinases; D018384:Oxidative Stress; D000080662:Phospholipid Hydroperoxide ... | Biochemical and biophysical research communications | 2,017 | D054778:NM23 Nucleoside Diphosphate Kinases; D004050:Ditiocarb; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D002374:Catalase; D005979:Glutathione Peroxidase; C523860:glutathione peroxidase 4, rat; C080439:selenium-independent glutathione peroxidase; C000606292:Sod1 protein, rat; D000072105:Superoxide ... |
A role for hemopexin in oligodendrocyte differentiation and myelin formation. | Myelin formation and maintenance are crucial for the proper function of the CNS and are orchestrated by a plethora of factors including growth factors, extracellular matrix components, metalloproteases and protease inhibitors. Hemopexin (Hx) is a plasma protein with high heme binding affinity, which is also locally pro... | 10.1371/journal.pone.0020173 | 21,633,699 | D000818:Animals; D015153:Blotting, Western; D001921:Brain; D002454:Cell Differentiation; D002478:Cells, Cultured; D006466:Hemopexin; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D057507:Mice, 129 Strain; D018345:Mice, Knockout; D046529:Microscopy, Electron, Transmission; D009043:Motor Activity; D009186:M... | PloS one | 2,011 | D006466:Hemopexin |
Acute reversal by saralasin of multiple intrarenal effects of angiotensin II. | Glomerular hemodynamics were measured by micropuncture technique in the plasma volume-expanded Munich-Wistar rat in 1) a control group, 2) during a pressor infusion of angiotensin II (AII), and 3) during simultaneous infusions of AII and saralasin, which returned arterial pressure to normal. Respective values obtained ... | 10.1152/ajprenal.1979.237.5.F386 | 495,754 | D000804:Angiotensin II; D000818:Animals; D002199:Capillary Permeability; D002200:Capillary Resistance; D005919:Glomerular Filtration Rate; D007678:Kidney Glomerulus; D008297:Male; D051381:Rats; D012039:Regional Blood Flow; D012504:Saralasin | The American journal of physiology | 1,979 | D000804:Angiotensin II; D012504:Saralasin |
Theoretical and experimental considerations of the pseudo-first-order approximation in conventional kinetic analysis of IAsys biosensor data. | The validity of the conventional interpretation of IAsys biosensor profiles in terms of pseudo-first-order kinetic behavior is subjected to closer scrutiny by its application to simulated data for low- and high-affinity interactions between ligate and immobilized ligand. As might reasonably have been expected, analysis... | 10.1006/abio.1997.2358 | 9,367,496 | D000327:Adsorption; D015374:Biosensing Techniques; D003198:Computer Simulation; D006801:Humans; D007074:Immunoglobulin G; D007700:Kinetics; D008024:Ligands; D008956:Models, Chemical; D011485:Protein Binding; D011506:Proteins; D012710:Serum Albumin, Bovine; D013816:Thermodynamics | Analytical biochemistry | 1,997 | D007074:Immunoglobulin G; D008024:Ligands; D011506:Proteins; C017887:histidine-rich proteins; D012710:Serum Albumin, Bovine |
Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis. | Based on the tetracycline-regulated gene expression system, a double-transgenic mouse model for liver fibrosis was established in which the expression of transforming growth factor beta1 (TGF-beta1) can be regulated deliberately by addition or removal of doxycycline hydrochloride to the drinking water. TGF-beta1 plasma... | 10.1053/jhep.2003.50196 | 12,717,387 | D000818:Animals; D000900:Anti-Bacterial Agents; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins; D015870:Gene Expression; D007150:Immunohistochemistry; D008099:Liver; D008103:Liver Cirrhosis; D051379:Mice; D008822:Mice, Transgenic; D013752:Tetracycline; D016212:Transforming Growth Factor beta; D05... | Hepatology (Baltimore, Md.) | 2,003 | D000900:Anti-Bacterial Agents; D016326:Extracellular Matrix Proteins; C508961:Tgfb1 protein, mouse; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D013752:Tetracycline |
Reliability and validity of child/adolescent food frequency questionnaires that assess foods and/or food groups. | OBJECTIVE
Summarize the validity and reliability of child/adolescent food frequency questionnaires (FFQs) that assess food and/or food groups.
METHODS
We performed a systematic review of child/adolescent (6-18 years) FFQ studies published between January 2001 and December 2010 using MEDLINE, Cochrane Library, PsycINF... | 10.1097/MPG.0b013e318251550e | 22,437,477 | D000293:Adolescent; D002648:Child; D004032:Diet; D005502:Food; D006801:Humans; D009749:Nutrition Surveys; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires | Journal of pediatric gastroenterology and nutrition | 2,012 | |
Phaedra, a protocol-driven system for analysis and validation of high-content imaging and flow cytometry. | High-content screening has brought new dimensions to cellular assays by generating rich data sets that characterize cell populations in great detail and detect subtle phenotypes. To derive relevant, reliable conclusions from these complex data, it is crucial to have informatics tools supporting quality control, data re... | 10.1177/1087057111432885 | 22,233,649 | D019295:Computational Biology; D001330:Electronic Data Processing; D005434:Flow Cytometry; D057166:High-Throughput Screening Assays; D007091:Image Processing, Computer-Assisted; D020407:Internet; D012984:Software; D014584:User-Computer Interface | Journal of biomolecular screening | 2,012 | |
Year in review 2013: Critical Care - nephrology. | We review original research in the field of critical care nephrology accepted or published in 2013 in Critical Care and, when considered relevant or linked to these studies, in other journals. Three main topics have been identified and are discussed for a rapid overview: acute kidney injury (diagnosis, risk factors and... | 10.1186/s13054-014-0574-1 | 25,426,759 | D058186:Acute Kidney Injury; D003422:Critical Care; D015199:Extracorporeal Membrane Oxygenation; D006439:Hemodynamics; D006801:Humans; D011379:Prognosis; D017582:Renal Replacement Therapy; D012307:Risk Factors | Critical care (London, England) | 2,014 | |
Pain Part 4: Odontogenic Pain. | UNLABELLED
Pain is one of the major reasons that lead patients to seek dental care. For the majority of patients, the pain is of odontogenic origin, as a consequence of dental disease. The timely diagnosis and management of dental pain is an essential component of dental care, and this article reminds readers of the co... | 10.12968/denu.2015.42.7.622 | 26,630,860 | D000900:Anti-Bacterial Agents; D003387:Cracked Tooth Syndrome; D003788:Dental Pulp Diseases; D003791:Dental Pulp Test; D012534:Dental Scaling; D003937:Diagnosis, Differential; D006801:Humans; D009437:Neuralgia; D010347:Patient Care Planning; D010510:Periodontal Diseases; D011312:Pressure; D016300:Radiography, Bitewing;... | Dental update | 2,015 | D000900:Anti-Bacterial Agents |
Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. | Asymmetric and symmetric dimethylarginines (ADMA and SDMA) impair nitric oxide bioavailability and have been implicated in the pathogenesis of atrial fibrillation (AF). Alanine-glyoxylate aminotransferase 2 (AGXT2) is the only enzyme capable of metabolizing both of the dimethylarginines. We hypothesized that two functi... | 10.1038/srep23207 | 26,984,639 | D000368:Aged; D000483:Alleles; D000792:Angiography; D001281:Atrial Fibrillation; D016022:Case-Control Studies; D002908:Chronic Disease; D015331:Cohort Studies; D003331:Coronary Vessels; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missen... | Scientific reports | 2,016 | D000637:Transaminases; C019635:Alanine-glyoxylate transaminase |
C-terminal Lysine-Linked Magainin 2 with Increased Activity Against Multidrug-Resistant Bacteria. | Due to the growing problem of antibiotic-resistant microorganisms, the development of novel antimicrobial agents is a very important challenge. Dimerization of cationic antimicrobial peptides (cAMPs) is a potential strategy for enhancing antimicrobial activity. Here, we studied the effects of magainin 2 (MG2) dimerizat... | 10.2174/0929866523666160511150907 | 27,165,408 | D000890:Anti-Infective Agents; D002942:Circular Dichroism; D019281:Dimerization; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli; D008239:Lysine; D054806:Magainins; D008826:Microbial Sensitivity Tests; D010455:Peptides; D013329:Structure-Activity Relationship; D013997:Time Factors | Protein and peptide letters | 2,016 | D000890:Anti-Infective Agents; D054806:Magainins; D010455:Peptides; D008239:Lysine |
Serotonin induces long-term depression at corticostriatal synapses. | The striatum has important roles in motor control and action learning and, like many brain regions, receives multiple monoaminergic inputs. We have examined serotonergic modulation of rat and mouse corticostriatal neurotransmission and find that serotonin (5-HT) activates 5-HT(1b) receptors resulting in a long-term dep... | 10.1523/JNEUROSCI.6250-10.2011 | 21,593,324 | D000818:Animals; D002540:Cerebral Cortex; D003342:Corpus Striatum; D036881:Long-Term Synaptic Depression; D051379:Mice; D008822:Mice, Transgenic; D051381:Rats; D017207:Rats, Sprague-Dawley; D044302:Receptor, Serotonin, 5-HT1B; D012701:Serotonin; D013569:Synapses | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,011 | D044302:Receptor, Serotonin, 5-HT1B; D012701:Serotonin |
Canine β-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs. | BACKGROUND
Canine leishmaniasis caused by Leishmania infantum is a parasitic disease of great veterinary significance. Some dogs infected by L. infantum may mount a strong cellular immune response and clear the infection, while others may respond with exaggerated antibody production against the parasite and develop an ... | 10.1186/s13071-017-2130-8 | 28,427,438 | D000818:Animals; D001938:Brazil; D004283:Dog Diseases; D004285:Dogs; D005819:Genetic Markers; D007111:Immunity, Cellular; D007558:Italy; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D023083:beta-Defensins | Parasites & vectors | 2,017 | D005819:Genetic Markers; D023083:beta-Defensins |
Severe akathisia during olanzapine treatment of acute schizophrenia. | Olanzapine is a newly developed atypical neuroleptic with a marked affinity to the 5-HT2, D2 and D4 dopamine receptors. Like other atypical neuroleptics olanzapine is considered to show a reduced prevalence of extrapyramidal side effects when compared to classical neuroleptic drugs. We report on three patients with acu... | 10.1055/s-2007-979317 | 9,754,850 | D000328:Adult; D017109:Akathisia, Drug-Induced; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D005260:Female; D006801:Humans; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine; D012559:Schizophrenia | Pharmacopsychiatry | 1,998 | D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine |
Frequent gains and losses of specific chromosome segments in human ovarian carcinomas shown by comparative genomic hybridization. | Total genomic DNA obtained from 24 ovarian carcinomas was examined for genomic imbalances by comparative genomic hybridization (CGH). A varying number of gains and losses (1 up to 31) of specific chromosomal segments was detected per tumor. Chromosomal segments which were most often present in increased copy numbers we... | 10.3892/ijo.11.1.19 | 21,528,175 | International journal of oncology | 1,997 | ||
Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. | Members of the Toll-like receptor family are essential components of the innate immune system. Herein we report the molecular cloning and characterization of three novel human Toll-like receptors (hTLRs) designated hTLR7, hTLR8, and hTLR9. Human TLR7-9, like the previously described members hTLR1-6 contain an ectodomai... | 11,022,120 | D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D003001:Cloning, Molecular; D029721:Drosophila Proteins; D019143:Evolution, Molecular; D005091:Exons; D005786:Gene Expression Regulation; D006801:Humans; D008562:Membrane Glycoproteins; D051379:Mice; D008969:Molecular Sequence Data; D016328:NF-kappa... | European cytokine network | 2,000 | D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D020033:Protein Isoforms; D011956:Receptors, Cell Surface; C495348:TLR7 protein, human; C495349:TLR8 protein, human; C495371:TLR9 protein, human; D051199:Toll-Like Receptor 7; D051200:Toll-Like Receptor 8; D051217:Toll-Like Receptor 9; D05... | |
Monitoring for bovine spongiform encephalopathy in sheep in Great Britain, 1998-2004. | Bovine spongiform encephalopathy (BSE) may have been transmitted to British sheep via contaminated feed in the 1980s. Strain-typing techniques based on immunohistochemical (IHC) detection of abnormal protein (PrP(d)) and the molecular analysis of proteinase-resistant protein (PrP(res)) by Western blotting (WB) can disc... | 10.1099/vir.0.81254-0 | 16,760,414 | D000818:Animals; D015153:Blotting, Western; D001923:Brain Chemistry; D002417:Cattle; D003937:Diagnosis, Differential; D016643:Encephalopathy, Bovine Spongiform; D007150:Immunohistochemistry; D011328:Prions; D011446:Prospective Studies; D012189:Retrospective Studies; D012608:Scrapie; D012756:Sheep; D012757:Sheep Disease... | The Journal of general virology | 2,006 | D011328:Prions |
Proximal amputation of inferior extremity secondary to recurrent pressure ulcers in patients with spinal cord injuries. | STUDY DESIGN
Descriptive case series study.
OBJECTIVE
To describe the course of five spinal cord injury (SCI) patients who underwent proximal amputation of the inferior extremity, secondary to recurrent, complicated pressure ulcers (PU) and the clinical impact this intervention had in these patients.
PLACE
Trabajad... | 10.1038/sj.sc.3102089 | 17,607,312 | D000671:Amputation, Surgical; D002908:Chronic Disease; D006428:Hemipelvectomy; D006760:Hospitalization; D006801:Humans; D007866:Leg; D008297:Male; D010019:Osteomyelitis; D003668:Pressure Ulcer; D013119:Spinal Cord Injuries; D016896:Treatment Outcome | Spinal cord | 2,008 | |
[Fluoroquinolones in respiratory infections]. | Given orally, currently marketed fluoroquinolones, ciprofloxacin, ofloxacin and pefloxacin are absorbed rapidly, have an excellent diffusion coefficient. They are wide-spectrum first intention antibiotics effective against Gram negative bacilli, staphylococci and intracellular germs such as Legionella, Chlamydiae and m... | 7,831,243 | D000818:Animals; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D006801:Humans; D010038:Otorhinolaryngologic Diseases; D012141:Respiratory Tract Infections | Presse medicale (Paris, France : 1983) | 1,994 | D000890:Anti-Infective Agents; D024841:Fluoroquinolones | |
Generalized Extraction and Classification of Span-Level Clinical Phrases. | Much of the critical information in a patient's electronic health record (EHR) is hidden in unstructured text. As such, there is an increasing role for automated text extraction and summarization to make this information available in a way that can be quickly and easily understood. While many clinical note text extract... | 30,815,058 | D057286:Electronic Health Records; D006801:Humans; D016247:Information Storage and Retrieval; D009323:Natural Language Processing | AMIA ... Annual Symposium proceedings. AMIA Symposium | 2,018 | ||
External validation of the Memorial Sloan Kettering Cancer Centre and Briganti nomograms for the prediction of lymph node involvement of prostate cancer using clinical stage assessed by magnetic resonance imaging. | OBJECTIVES
To evaluate the impact of using clinical stage assessed by multiparametric magnetic resonance imaging (mpMRI) on the performance of two established nomograms for the prediction of pelvic lymph node involvement (LNI) in patients with prostate cancer.
PATIENTS AND METHODS
Patients undergoing robot-assisted e... | 10.1111/bju.15376 | 33,630,398 | D000368:Aged; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D000081364:Multiparametric Magnetic Resonance Imaging; D009367:Neoplasm Staging; D049451:Nomograms; D011471:Prostatic Neoplasms; D012189:Retrospective Studies | BJU international | 2,021 | |
Exosomes in atrial fibrillation: therapeutic potential and role as clinical biomarkers. | Atrial fibrillation (AF), the most common cardiac arrhythmia, is a global epidemic. AF can cause heart failure and myocardial infarction and increase the risk of stroke, disability, and thromboembolic events. AF is becoming increasingly ubiquitous and is associated with increased morbidity and mortality at higher ages,... | 10.1007/s10741-021-10142-5 | 34,251,579 | D000889:Anti-Arrhythmia Agents; D001281:Atrial Fibrillation; D015415:Biomarkers; D017115:Catheter Ablation; D055354:Exosomes; D006801:Humans; D035683:MicroRNAs | Heart failure reviews | 2,022 | D000889:Anti-Arrhythmia Agents; D015415:Biomarkers; D035683:MicroRNAs |
Genetic mapping of quantitative trait loci for milk production in sheep. | A backcross pedigree using dairy East Friesian rams and non-dairy Dorset ewes was established specifically to map quantitative trait loci (QTL) affecting milk production in sheep. Ninety nine microsatellite markers of an initial set of 120 were successfully genotyped and informative on 188 animals of this backcross ped... | 10.1111/j.1365-2052.2010.02045.x | 20,394,603 | D000818:Animals; D002417:Cattle; D002611:Cheese; D003433:Crosses, Genetic; D005260:Female; D007774:Lactation; D008297:Male; D008892:Milk; D010375:Pedigree; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D034561:Sheep, Domestic; D026801:Synteny; D014481:United States | Animal genetics | 2,010 |
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