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A comparison of two group-delivered social skills programs for young children with autism. | A social skills group intervention was developed and evaluated for young children with autism. Twenty-five 4- to 6-year-old (diagnosed) children were assigned to one of two kinds of social skills groups: the direct teaching group or the play activities group. The direct teaching group used a video-modeling format to te... | 10.1007/s10803-006-0207-x | 16,927,011 | D001321:Autistic Disorder; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D007806:Language Disorders; D007858:Learning; D008297:Male; D015588:Observer Variation; D016730:Program Development; D012919:Social Behavior | Journal of autism and developmental disorders | 2,007 | |
Analytical method of measuring tea catechins in human plasma by solid-phase extraction and HPLC with electrochemical detection. | We developed an analytical method for measuring tea catechins in plasma by solid-phase extraction (SPE), followed by HPLC with a coulometric electrochemical detector. The plasma was mixed with an equal volume of acetonitrile to precipitate protein, and catechins in the resulting supernatant were extracted by SPE, using... | 10.3177/jnsv.47.402 | 11,922,115 | D000328:Adult; D002392:Catechin; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013662:Tea; D013997:Time Factors | Journal of nutritional science and vitaminology | 2,001 | D013662:Tea; D002392:Catechin |
Infusional high-dose application of the calcium-channel-blocking and antiglutamatergic agent caroverine in the treatment of alcohol withdrawal (DSM-III-R 291.80). | In an open study, nineteen in-patients fulfilling the criteria for an alcohol withdrawal syndrome (DSM-III-R 291.80) were treated with intravenous caroverine (400 mg/12 h). Caroverine is a class B calcium-channel-blocker and antiglutamatergic agent with significant effects on the brain function. Caroverine exhibits com... | 10.1016/s0924-977x(97)00057-6 | 9,716,312 | D000328:Adult; D000438:Alcohols; D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D016202:N-Methylaspartate; D010865:Pilot Projects; D011810:Quinoxalines; D013375:Substa... | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology | 1,998 | D000438:Alcohols; D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D011810:Quinoxalines; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; C000957:caroverine |
A 125 kDa RNase E/G-like protein is present in plastids and is essential for chloroplast development and autotrophic growth in Arabidopsis. | Endoribonuclease E (RNase E) is a regulator of global gene expression in Escherichia coli and is the best studied member of the RNase E/G ribonuclease family. Homologues are present in other bacteria but the roles of plant RNase E/G-like proteins are not known. Arabidopsis thaliana contains a single nuclear gene (At2g0... | 10.1093/jxb/ern126 | 18,515,828 | D000595:Amino Acid Sequence; D017360:Arabidopsis; D029681:Arabidopsis Proteins; D002736:Chloroplasts; D004926:Escherichia coli; D018506:Gene Expression Regulation, Plant; D008969:Molecular Sequence Data; D008970:Molecular Weight; D052817:Phototrophic Processes; D018087:Plastids; D017434:Protein Structure, Tertiary; D01... | Journal of experimental botany | 2,008 | D029681:Arabidopsis Proteins; D018749:RNA, Plant; D011994:Recombinant Proteins |
Neighborhood Socioeconomic Disadvantage and Care After Myocardial Infarction in the National Cardiovascular Data Registry. | BACKGROUND
Patients living in disadvantaged neighborhoods are at high risk for adverse outcomes after acute myocardial infarction (MI). Whether residential socioeconomic status (SES) is associated with quality of in-hospital care among patients presenting with MI is unclear.
METHODS AND RESULTS
Multivariable logistic... | 10.1161/CIRCOUTCOMES.117.004054 | 29,848,476 | D002318:Cardiovascular Diseases; D017023:Coronary Angiography; D054625:Healthcare Disparities; D017052:Hospital Mortality; D006801:Humans; D011203:Poverty; D019984:Quality Indicators, Health Care; D012042:Registries; D012111:Residence Characteristics; D012307:Risk Factors; D012923:Social Class; D064890:Social Determina... | Circulation. Cardiovascular quality and outcomes | 2,018 | |
A ban on BAM: an update on inhibitors of the β-barrel assembly machinery. | Gram-negative pathogens are a rapidly increasing threat to human health worldwide due to high rates of antibiotic resistance and the lack of development of novel antibiotics. The protective cell envelope of gram-negative bacteria is a major permeability barrier that contributes to the problem by restricting the uptake ... | 10.1093/femsle/fnab059 | 34,048,543 | D000900:Anti-Bacterial Agents; D000080943:Bacterial Outer Membrane; D001425:Bacterial Outer Membrane Proteins; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria; D006801:Humans; D009154:Mutation; D014774:Virulence | FEMS microbiology letters | 2,021 | D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins |
Super silyl-based stable protecting groups for both the C- and N-terminals of peptides: applied as effective hydrophobic tags in liquid-phase peptide synthesis. | Tag-assisted liquid-phase peptide synthesis (LPPS) is one of the important processes in peptide synthesis in pharmaceutical discovery. Simple silyl groups have positive effects when incorporated in the tags due to their hydrophobic properties. Super silyl groups contain several simple silyl groups and play an important... | 10.1039/d3sc01239e | 37,206,381 | Chemical science | 2,023 | ||
Thymus-mediated immune tolerance to renal allograft is donor but not tissue specific. | Studies were conducted in Lewis (RT1l) rats to determine whether the process of unresponsiveness to kidney graft induced by the intrathymic glomerular transplantation were donor-strain specific as suggested by previous studies (Remuzzi et al., Lancet 1991;337:750-752). When glomeruli from Sprague-Dawley rats were injec... | 10.1681/ASN.V261063 | 1,777,586 | D000818:Animals; D006085:Graft Survival; D007108:Immune Tolerance; D007519:Isoantigens; D007678:Kidney Glomerulus; D016030:Kidney Transplantation; D017708:Leukocyte Transfusion; D007962:Leukocytes; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D013601:T-Lym... | Journal of the American Society of Nephrology : JASN | 1,991 | D007519:Isoantigens |
Electrophysiological properties of identified postnatal rat hippocampal pyramidal neurons in primary culture. | Electrophysiological experiments were performed on primary cell cultures of retrogradely labelled postnatal rat hippocampal neurons. Rhodamine microspheres injected into the dorsal fornix clearly labelled the pyramidal cell layer of the hippocampus while excluding the other hippocampal layers and the dentate gyrus. In ... | 10.1016/0165-3806(93)90100-o | 8,094,325 | D000200:Action Potentials; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D004594:Electrophysiology; D005971:Glutamates; D018698:Glutamic Acid; D006624:Hippocampus; D008564:Membrane Potentials; D009474:Neurons; D011712:Pyramidal Tracts; D051381:Rats; D012235:Rhodamines; D013997:Time Factors; D00568... | Brain research. Developmental brain research | 1,993 | D005971:Glutamates; D012235:Rhodamines; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid |
Micellar structures in nanoparticle-multiblock copolymer complexes. | Brownian dynamics simulation is employed to examine the structure changes of complexes composed of a hydrophobic nanoparticle and a multiblock copolymer molecule (MCP). The dependence of the structure transitions on the radius of the nanoparticle, on the interactions between the hydrophobic segments of the MCP, and on ... | 10.1021/la500450b | 24,628,090 | Langmuir : the ACS journal of surfaces and colloids | 2,014 | ||
Compression of Spin-Adapted Multiconfigurational Wave Functions in Exchange-Coupled Polynuclear Spin Systems. | We present a protocol based on unitary transformations of molecular orbitals to reduce the number of nonvanishing coefficients of spin-adapted configuration interaction expansions. Methods that exploit the sparsity of the Hamiltonian matrix and compactness of its eigensolutions, such as the full configuration interacti... | 10.1021/acs.jctc.9b01013 | 32,053,374 | Journal of chemical theory and computation | 2,020 | ||
Development and validation of eco-friendly micellar-HPLC and HPTLC-densitometry methods for the simultaneous determination of paritaprevir, ritonavir and ombitasvir in pharmaceutical dosage forms. | Ombitasvir, ritonavir and paritaprevir are three recently discovered directly acting antiviral drugs (DAADs) used in combined single dose tablet dosage form for treatment of hepatitis-C viral infections (HCV). The methods of analysis followed by quality control and research laboratories are required to be economic and ... | 10.1016/j.heliyon.2019.e01518 | 31,049,430 | Heliyon | 2,019 | ||
Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis. | Background In sepsis, circulating cytokines and lipopolysaccharide elicit mitochondrial dysfunction and cardiomyopathy, a major cause of morbidity and mortality with this condition. Emerging research places the PHB1 (lipid raft protein prohibitin-1) at the nexus of inflammation, metabolism, and oxidative stress. PHB1 h... | 10.1161/JAHA.120.019877 | 34,219,469 | D000818:Animals; D017209:Apoptosis; D001798:Blood Proteins; D002316:Cardiotonic Agents; D016207:Cytokines; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D032383:Myocytes, Cardiac; D000091402:Prohibitins; D017207:Rats, Sprague-Dawley; D012097:Repressor Proteins; D018805:Sepsis; D01... | Journal of the American Heart Association | 2,021 | D001798:Blood Proteins; D002316:Cardiotonic Agents; D016207:Cytokines; D008070:Lipopolysaccharides; C000717328:PHB protein, human; D000091402:Prohibitins; D012097:Repressor Proteins |
[Features of ultrasound diagnosis of non-epithelial ovarian carcinoma]. | Ultrasound examination using color Doppler imaging was used in 70 patients with non-epithelial ovarian carcinoma and 23 patients with subserous nodes of uterine myoma. Diagnosis was confirmed by histological assay of resected material. The procedure can be used for differentiated diagnosis between non-epithelial ovaria... | 18,198,619 | D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009214:Myoma; D010051:Ovarian Neoplasms; D014463:Ultrasonography | Voprosy onkologii | 2,007 | ||
Application of disability-adjusted life years to predict the burden of injuries and fatalities due to public exposure to engineering technologies. | BACKGROUND
As a public safety regulator, the Technical Standards and Safety Authority (TSSA) of Ontario, Canada predicts and measures the burden of injuries and fatalities as its primary means of characterizing the state of public safety and for decision-making purposes through the use of a simulation model. The paper ... | 10.1186/1478-7954-12-9 | 24,674,101 | Population health metrics | 2,014 | ||
The analysis of treatment of aggressive fibromatosis using oral methotrexate chemotherapy. | BACKGROUND
Aggressive fibromatosis is a rare but invasive tumor infiltrating widely between fascia and muscle fibers. It has a high tendency to be locally recurrent despite complete resection. Effectiveness of adjuvant treatment for aggressive fibromatosis including radiotherapy, pharmacological agents, hormonal treatm... | 10.4055/cios.2014.6.4.439 | 25,436,069 | D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic; D002648:Child; D005260:Female; D018222:Fibromatosis, Aggressive; D006801:Humans; D008297:Male; D008727:Methotrexate; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Stud... | Clinics in orthopedic surgery | 2,014 | D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate |
Aircraft noise control policy and mental health: a natural experiment based on the Longitudinal Aging Study Amsterdam (LASA). | BACKGROUND
This study examines the impact of environmental noise policy on depressive symptoms by exploiting the national experiment afforded by the New Deal aircraft noise control policy introduced in Schiphol (Amsterdam) in 2008.
METHODS
Data came from older adults (ages 57-102) participating in three waves (2005/2... | 10.1136/jech-2020-214264 | 33,148,682 | D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000401:Aircraft; D006801:Humans; D008603:Mental Health; D008875:Middle Aged; D009624:Noise, Transportation; D057766:Policy | Journal of epidemiology and community health | 2,021 | |
The use of neoadjuvant chemotherapy in advanced endometrial cancer. | The objective of this retrospective cohort study was to review the use of neoadjuvant chemotherapy followed by interval cytoreductive surgery in patients presenting with advanced, unresectable endometrial cancer at two large cancer centers. Patients with advanced endometrial cancer treated with neoadjuvant chemotherapy... | 10.1016/j.gore.2021.100725 | 33,644,284 | Gynecologic oncology reports | 2,021 | ||
A short sequence within two purine-rich enhancers determines 5' splice site specificity. | Purine-rich enhancers are exon sequences that promote inclusion of alternative exons, usually via activation of weak upstream 3' splice sites. A recently described purine-rich enhancer from the caldesmon gene has an additional activity by which it directs selection of competing 5' splice sites within an alternative exo... | 10.1128/MCB.18.1.343 | 9,418,881 | D000818:Animals; D002148:Calmodulin-Binding Proteins; D002645:Chickens; D004742:Enhancer Elements, Genetic; D006367:HeLa Cells; D006801:Humans; D011687:Purines; D012326:RNA Splicing; D017421:Sequence Analysis; D014336:Troponin; D020107:Troponin T | Molecular and cellular biology | 1,998 | D002148:Calmodulin-Binding Proteins; D011687:Purines; D014336:Troponin; D020107:Troponin T; C030985:purine |
Association of Regular Thrombus Surface Phenotype With Complete Recanalization in First-Line Contact Aspiration Thrombectomy for Basilar Artery Occlusion. | Objective: To assess whether angiographic thrombus surface phenotype has an impact on efficacy of contact aspiration (CA) thrombectomy in patients with basilar artery occlusion (BAO). Methods: From January 2016 to December 2019, consecutive stroke patients with a BAO and first-line CA were analyzed in this retrospectiv... | 10.3389/fneur.2021.666933 | 34,566,832 | Frontiers in neurology | 2,021 | ||
The influence of purification and protein heterogeneity on the crystallization of p-hydroxybenzoate hydroxylase. | The structure of the enzyme p-hydroxybenzoate hydroxylase was determined to a resolution of 0.25 nm [Wierenga et al. (1979) J. Mol. Biol. 131, 53-73] with crystals belonging to space group C222(1). Subsequently it was impossible to repeat the growth of this crystal form and only poor quality tetragonal crystals could b... | 10.1111/j.1432-1033.1989.tb14605.x | 2,920,736 | D015109:4-Hydroxybenzoate-3-Monooxygenase; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003460:Crystallization; D006899:Mixed Function Oxygenases; D010084:Oxidation-Reduction | European journal of biochemistry | 1,989 | D006899:Mixed Function Oxygenases; D015109:4-Hydroxybenzoate-3-Monooxygenase |
Nesting Behavior, Phenology, and Bionomics of the High Andean Leaf-Cutter Bee Megachile (Cressoniella) amparo. | Megachile amparo (González, Revista Colombiana De Entomología 32(1):93-96, 2006) is the only high Andean leaf-cutter bee reported in Colombia and is possibly endemic to the Colombian Andes. Although it is frequently observed, even in urban areas, its biology and ecology remain unknown. The present study aimed to descri... | 10.1007/s13744-023-01061-1 | 37,369,980 | D006801:Humans; D008297:Male; D001516:Bees; D005260:Female; D000818:Animals; D009425:Nesting Behavior; D004463:Ecology; D005502:Food; D000074767:Diapause; D012744:Sex Ratio | Neotropical entomology | 2,023 | |
Renal regulation of plasma glucose in the freshwater rainbow trout. | This study examined the effects of prolonged hyperglycemia on renal handling of glucose and explored the in vivo pharmacological effects of phlorizin on glucose transport in the rainbow trout. The transport of glucose was examined by experimentally elevating the rate of renal glucose reabsorption via infusion of the fi... | 10.1242/jeb.01668 | 16,000,542 | D000704:Analysis of Variance; D000818:Animals; D001693:Biological Transport, Active; D001786:Blood Glucose; D004231:Diuresis; D005618:Fresh Water; D051246:Glucose Transport Proteins, Facilitative; D006029:Glycosuria; D007668:Kidney; D017686:Oncorhynchus mykiss; D010695:Phlorhizin; D012964:Sodium | The Journal of experimental biology | 2,005 | D001786:Blood Glucose; D051246:Glucose Transport Proteins, Facilitative; D012964:Sodium; D010695:Phlorhizin |
CT diagnosis of renal cyst wall tumor. | Renal cysts are common lesions especially in the older population. Although the occurrence of a tumor within the wall of an otherwise benign cyst is rare, its accurate diagnosis is difficult. We present such a case, diagnosed preoperatively by computed tomography. | 10.1097/00004728-198306000-00033 | 6,841,727 | D005260:Female; D006801:Humans; D052177:Kidney Diseases, Cystic; D007680:Kidney Neoplasms; D008875:Middle Aged; D014057:Tomography, X-Ray Computed | Journal of computer assisted tomography | 1,983 | |
Estimating source terms for far field dredge plume modelling. | Far field modelling of dredging induced suspended sediment plumes is important while assessing the environmental aspects of dredging. Realistic estimation of source terms, that define the suspended sediment input for far field dredge plume modelling, is key to any assessment. This paper describes a generic method for s... | 25,463,591 | D004058:Diffusion; D004777:Environment; D004784:Environmental Monitoring; D019015:Geologic Sediments; D057446:Hydrodynamics; D008962:Models, Theoretical; D014872:Water Movements | Journal of environmental management | 2,015 | ||
Recent advances in the pharmacological management of constipation predominant irritable bowel syndrome. | Introduction: Irritable bowel syndrome (IBS) is a complex functional gut disorder that typically manifests in early adult years. More than a third of IBS patients are diagnosed with predominant constipation subtype (IBS-C). This syndrome has a distressing impact on the quality of life and is challenging both for patien... | 10.1080/14656566.2019.1688784 | 31,724,881 | D000328:Adult; D003248:Constipation; D005765:Gastrointestinal Agents; D006801:Humans; D043183:Irritable Bowel Syndrome; D011788:Quality of Life | Expert opinion on pharmacotherapy | 2,020 | D005765:Gastrointestinal Agents |
Can paying for results help to achieve the Millennium Development Goals? Overview of the effectiveness of results-based financing. | OBJECTIVE
Results-based financing and pay-for-performance refer to the transfer of money or material goods conditional on taking a measurable action or achieving a predetermined performance target. Results-based financing is widely advocated for achieving health goals, including the Millennium Development Goals.
METH... | 10.1111/j.1756-5391.2009.01020.x | 21,348,993 | D003695:Delivery of Health Care; D005381:Financing, Organized; D006801:Humans | Journal of evidence-based medicine | 2,009 | |
Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes. | We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two protot... | 10.1364/BOE.4.002596 | 24,298,418 | Biomedical optics express | 2,013 | ||
Monooxygenase-catalyzed regioselective hydroxylation for the synthesis of hydroxyequols. | Monooxygenases exhibiting high activity and differing regioselectivity for the dietary isoflavone metabolite equol were discovered among enzymes in the HpaBC family by a genome mining approach. These enzymes enabled the one-step product-selective synthesis of 3'- and 6-hydroxyequols from equol and molecular oxygen. | 10.1039/c9ra03913a | 35,518,870 | RSC advances | 2,019 | ||
Provider perspectives on employment for people with serious mental illness. | BACKGROUND
Persons with serious mental illnesses (SMI) can lead productive lives, and the majority want to work. Mental health providers can play an important role in helping their clients gain and maintain employment.
AIMS
The Provider Survey was developed to shed additional light on providers' views toward employme... | 10.1177/0020764017725769 | 28,797,214 | D003237:Connecticut; D003430:Cross-Sectional Studies; D016832:Employment, Supported; D006801:Humans; D001523:Mental Disorders; D008605:Mental Health Services; D011640:Public Policy; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires | The International journal of social psychiatry | 2,017 | |
Frequency of Stent Thrombosis Risk at 5 Years in Women Versus Men With Zotarolimus-Eluting Compared With Sirolimus-Eluting Stent. | The prevalence of factors that are associated with an increased risk of stent thrombosis (ST), including smoking, diabetes mellitus, and small stent size, is different in women and men who underwent percutaneous coronary intervention. Thus, gender may potentially modify the relation between stent type and the incidence... | 10.1016/j.amjcard.2016.07.032 | 27,569,387 | D000368:Aged; D000903:Antibiotics, Antineoplastic; D003324:Coronary Artery Disease; D003920:Diabetes Mellitus; D054855:Drug-Eluting Stents; D005260:Female; D006083:Graft Occlusion, Vascular; D006801:Humans; D007004:Hypoglycemic Agents; D007328:Insulin; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary In... | The American journal of cardiology | 2,016 | D000903:Antibiotics, Antineoplastic; D007004:Hypoglycemic Agents; D007328:Insulin; D010975:Platelet Aggregation Inhibitors; C489443:zotarolimus; D020123:Sirolimus |
Clinical Significance of Annexin A2 Expression in Breast Cancer Patients. | Increasing evidence suggests that AnxA2 contributes to invasion and metastasis of breast cancer. However, the clinical significance of AnxA2 expression in breast cancer has not been reported. The expression of AnxA2 in cell lines, tumor tissues, and serum samples of breast cancer patients were analyzed by immunoblottin... | 10.3390/cancers13010002 | 33,374,917 | Cancers | 2,020 | ||
Preparation and lithium storage of core-shell honeycomb-like Co3O4@C microspheres. | Core-shell honeycomb-like Co3O4@C microspheres were synthesized via a facile solvothermal method and subsequent annealing treatment under an argon atmosphere. Owing to the core-shell honeycomb-like structure, a long cycling life was achieved (a high reversible specific capacity of 318.9 mA h g-1 was maintained at 5C af... | 10.1039/d2ra05204k | 36,321,073 | RSC advances | 2,022 | ||
The inflammatory response induced by Pseudomonas aeruginosa in macrophages enhances apoptotic cell removal. | Pathogens phagocytosis and the uptake of apoptotic cells (efferocytosis) are essential macrophages tasks, classically considered as mutually exclusive. Macrophages have been observed to polarize into either pro-inflammatory/microbicidal or anti-inflammatory/efferocytic phenotypes. However, macrophage functions have sho... | 10.1038/s41598-021-81557-1 | 33,504,816 | D017209:Apoptosis; D002478:Cells, Cultured; D016207:Cytokines; D018836:Inflammation Mediators; D008264:Macrophages; D010587:Phagocytosis; D011552:Pseudomonas Infections; D011550:Pseudomonas aeruginosa | Scientific reports | 2,021 | D016207:Cytokines; D018836:Inflammation Mediators |
The label-free unambiguous detection and symbolic display of single nucleotide polymorphisms on DNA origami. | Single nucleotide polymorphisms (SNPs) are the most common genetic variation in the human genome. Kinetic methods based on branch migration have proved successful for detecting SNPs because a mispair inhibits the progress of branch migration in the direction of the mispair. We have combined the effectiveness of kinetic... | 10.1021/nl104555t | 21,235,216 | D004247:DNA; D004252:DNA Mutational Analysis; D018625:Microscopy, Atomic Force; D036103:Nanotechnology; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D013194:Staining and Labeling | Nano letters | 2,011 | D004247:DNA |
[Phytochemical investigation on Lysimachia fortunei]. | OBJECTIVE
To investigate the chemical constituents in the ethyl acerate extract of Lysimachia fortunei.
METHOD
The compounds were isolated by silica gel chromatography, and their structures were elucidated by NMR data and references.
RESULT
Nine natural constituents were isolated, and their structures were identifi... | 17,583,199 | D002774:Cholestadienes; D044948:Flavonols; D044949:Kaempferols; D019308:Palmitic Acid; D010946:Plants, Medicinal; D029623:Primulaceae; D011794:Quercetin; D014315:Triterpenes | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | 2,007 | C528672:24-ethyl-5alpha-cholesta-7,22(E)-dien-3-one; C528666:9,19-cyclolanost-24-en-3-one; D002774:Cholestadienes; D044948:Flavonols; D044949:Kaempferols; D014315:Triterpenes; C047368:3-methylquercetin; D019308:Palmitic Acid; C006552:kaempferol; D011794:Quercetin | |
Cardiac, Inflammatory and Metabolic Parameters: Hemodialysis versus Peritoneal Dialysis. | INTRODUCTION
Mortality in dialysis patients is higher than in the general population, and cardiovascular disease represents the leading cause of death. Hypertension and volume overload are important risk factors for the development of left ventricular hypertrophy (LVH) in hemodialysis (HD) and peritoneal dialysis (PD) ... | 10.1159/000369588 | 25,759,697 | Cardiorenal medicine | 2,015 | ||
Effects of aging on the myelination of the optic nerve in rats. | AIM OF THE STUDY
Cognitive decline due to aging is most probably the result of changes in the white matter in the central nervous system (CNS) and/or demyelination.
MATERIAL AND METHODS
We used electron microscopic analysis of the morphological changes in aging rats' optic nerves as an easily accessible part of the C... | 10.1080/00207454.2018.1529670 | 30,260,726 | D000367:Age Factors; D000375:Aging; D000818:Animals; D001369:Axons; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath; D009410:Nerve Degeneration; D009413:Nerve Fibers, Myelinated; D009900:Optic Nerve; D051381:Rats; D017207:Rats, Sprague-Dawley | The International journal of neuroscience | 2,019 | |
Cytology of hyperplastic endocrine cells of the pancreas in fine needle aspiration biopsy. | Hyperplastic endocrine cells of the pancreas occurred in small cohesive clusters with focal glandular arrangement in a fine needle aspirate. They showed pale, filmy, ill-defined cytoplasm and round to oval, slightly hyperchromatic nuclei with small nucleoli. | 6,380,185 | D000368:Aged; D001707:Biopsy, Needle; D002908:Chronic Disease; D006801:Humans; D006965:Hyperplasia; D007515:Islets of Langerhans; D008297:Male; D008875:Middle Aged; D010179:Pancreas; D010190:Pancreatic Neoplasms; D010195:Pancreatitis; D014057:Tomography, X-Ray Computed | Acta cytologica | 1,984 | ||
Recurrence after spontaneous resolution of an idiopathic epiretinal membrane. | We report a case of recurrent epiretinal membrane (ERM) after spontaneous resolution of an idiopathic ERM. A 65-year-old female demonstrated a spontaneous improvement in visual acuity from 0.1 to 1.2 in her left eye attributable to spontaneous resolution of idiopathic ERM due to posterior vitreous detachment. Thereafte... | 10.1159/000324462 | 22,110,437 | Case reports in ophthalmology | 2,011 | ||
Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing. | Ebola virus (EBOV) infection is a major public health concern due to high fatality rates and limited effective treatments. Statins, widely used cholesterol-lowering drugs, have pleiotropic mechanisms of action and were suggested as potential adjunct therapy for Ebola virus disease (EVD) during the 2013-2016 outbreak in... | 10.1128/mBio.00660-18 | 29,717,011 | D000998:Antiviral Agents; D002460:Cell Line; D029043:Ebolavirus; D019142:Hemorrhagic Fever, Ebola; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011499:Protein Processing, Post-Translational; D014759:Viral Envelope Proteins; D014774:Virulence; D053586:Virus Internalization | mBio | 2,018 | D000998:Antiviral Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014759:Viral Envelope Proteins |
Diphenyldichlorophosphonium trichloride-chlorine solvate 1:1, [PPh2Cl2]+Cl(3)(-).Cl2: an ionic form of diphenyltrichlorophosphorane. Crystal structures of [PPh2Cl2]+Cl(3)(-).Cl2 and [(PPh2Cl2)+]2[InCl5](2-). | An ionic form of diphenyltrichlorophosphorane, namely, diphenyldichlorophosphonium trichloride isolated as a dichlorine solvate (1), was obtained by treating PPh(2)Cl(3) with excess chlorine. The identity of this species was established by single-crystal X-ray analysis and (31)P, (1)H, and (35)Cl NMR and Raman spectra.... | 10.1021/ic034091n | 12,767,197 | Inorganic chemistry | 2,003 | ||
Free metanephrine in human amniotic fluid as an index of fetal sympathetic nervous system maturation. | Free metanephrine, a major metabolite of catecholamines, was measured in the amniotic fluid of 113 pregnant patients at various gestational ages. The results indicate that prior to 30 weeks the levels of free metanephrine are below the level of assay sensitivity. After 30 weeks' gestation there is a positive correlatio... | 434,011 | D000653:Amniotic Fluid; D004837:Epinephrine; D005260:Female; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D007743:Labor, Obstetric; D008676:Metanephrine; D011247:Pregnancy; D013564:Sympathetic Nervous System | American journal of obstetrics and gynecology | 1,979 | D008676:Metanephrine; D004837:Epinephrine | |
Three uses of an extra length of jejunum in pharyngo-oesophageal reconstruction with free jejunal flap. | BACKGROUND
The free jejunal flap is a widely spread method of pharyngo-oesophageal reconstruction and can also be used in patients presenting with aspiration tendency following treatment for head and neck cancers or caustic injury of the upper aero-digestive tract to create a separate food pathway, the free jejunal div... | 23,110,963 | D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D057868:Anastomotic Leak; D003679:Deglutition; D003680:Deglutition Disorders; D062109:Dermatologic Surgical Procedures; D004435:Eating; D004947:Esophagus; D005260:Female; D058752:Free Tissue Flaps; D006801:Humans; D007583:Jejunum; D008297:Male; D008875:Middle ... | Journal of plastic, reconstructive & aesthetic surgery : JPRAS | 2,013 | ||
Comments on the 5th edition of WHO classification of digestive system tumors - Part 1. Gastrointestinal tract. | The new 2019 WHO classification of digestive system tumors reflects some important advancements in our understanding of etiopathogenesis and molecular background of selected neoplastic diseases of the gastrointestinal tract, offers more integrated review of non-epithelial neoplasms and updates the spectrum of genetic t... | 33,736,440 | D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms; D014944:World Health Organization | Ceskoslovenska patologie | 2,020 | ||
Identification of α1-antitrypsin as a positive acute phase protein in ayu (Plecoglossus altivelis) associated with Listonella anguillarum infection. | α1-Antitrypsin (AAT) is implicated in the regulation of a variety of mammalian immune responses and was recently identified as a major serpin in blood plasma of some fish. However, AAT expression following bacterial infection in fish has not been well described. In this study, we cloned the full-length ayu (Plecoglossu... | 10.1016/j.fsi.2011.11.002 | 22,100,612 | D000818:Animals; D005393:Fish Diseases; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D016905:Gram-Negative Bacterial Infections; D053526:Listonella; D008969:Molecular Sequence Data; D036441:Osmeriformes; D010802:Phylogeny; D000515:alpha 1-Antitrypsin | Fish & shellfish immunology | 2,012 | D000515:alpha 1-Antitrypsin |
Clinical profile of patients with pleural effusion admitted to KMCTH. | BACKGROUND
Pleural effusion is the common findings in patients presenting with cardiopulmonary symptoms but specific studies are lacking in Nepal.
OBJECTIVE
The main objective of this study is to fi nd out the various causes of pleural effusion, their mode of clinical presentation and laboratory analysis of blood and... | 10.3126/kumj.v7i4.2772 | 20,502,092 | D000328:Adult; D000367:Age Factors; D000368:Aged; D015984:Causality; D015331:Cohort Studies; D015897:Comorbidity; D003906:Developing Countries; D005260:Female; D006333:Heart Failure; D006784:Hospitals, Teaching; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009390:Nepal; D010996:Pleural Effusio... | Kathmandu University medical journal (KUMJ) | 2,009 | |
A Qualitative Exploration of Medication Experience and Factors Contributing to Adherence to Oral-Targeted Therapy Among Lung Cancer Survivors. | OBJECTIVES
The introduction of oral-targeted therapy for cancer improves survival while adherence also presents as a challenge to patients. Current studies on oral anticancer agents are primarily limited to patients from developed countries with breast cancer and chronic myeloid leukemia receiving oral chemotherapy and... | 10.1016/j.soncn.2022.151352 | 36,253,304 | D006801:Humans; D002289:Carcinoma, Non-Small-Cell Lung; D000073116:Cancer Survivors; D008175:Lung Neoplasms; D000970:Antineoplastic Agents; D055118:Medication Adherence; D008168:Lung | Seminars in oncology nursing | 2,022 | D000970:Antineoplastic Agents |
In vivo and in vitro stability of the broad-host-range cloning vector pBBR1MCS in six Brucella species. | Previous studies have shown that the broad-host-range plasmid pBBR1MCS can be used for genetic complementation in Brucella abortus. To extend these observations, the in vivo and in vitro stability of pBBR1MCS was evaluated in the six currently recognized species of the genus Brucella. pBBR1MCS was readily introduced in... | 10.1006/plas.1995.1006 | 7,753,908 | D000818:Animals; D000900:Anti-Bacterial Agents; D015139:Blotting, Southern; D002002:Brucella; D002003:Brucella abortus; D017347:Brucella melitensis; D003001:Cloning, Molecular; D018274:Electroporation; D005816:Genetic Complementation Test; D005822:Genetic Vectors; D051379:Mice; D008807:Mice, Inbred BALB C; D010957:Plas... | Plasmid | 1,995 | D000900:Anti-Bacterial Agents |
Leucothrix arctica sp. nov., isolated from Arctic seawater. | A Gram-stain-negative, non-motile, oxidase- and catalase-positive, rod-shaped bacterium was isolated from a coastal seawater sample from the Arctic Circle and designated strain IMCC9719T. On the basis of 16S rRNA gene sequence analysis, it was shown that strain IMCC9719T belonged to the genus Leucothrix and was closely... | 10.1099/ijsem.0.003072 | 30,516,460 | D001110:Arctic Regions; D015373:Bacterial Typing Techniques; D001482:Base Composition; D004269:DNA, Bacterial; D005227:Fatty Acids; D010743:Phospholipids; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S; D012623:Seawater; D017422:Sequence Analysis, DNA; D041962:Thiotrichaceae; D014451:Ubiquinone | International journal of systematic and evolutionary microbiology | 2,018 | D004269:DNA, Bacterial; D005227:Fatty Acids; D010743:Phospholipids; D012336:RNA, Ribosomal, 16S; D014451:Ubiquinone; C030778:ubiquinone 8 |
Natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis: a postmortem study. | Natalizumab, a monoclonal antibody directed against α4 integrins, has, to date, been associated with 399 cases of progressive multifocal leukoencephalopathy (PML) worldwide in patients receiving treatment for multiple sclerosis (MS). Because of the limited number of histologic studies, the possible interplay between MS... | 10.1097/NEN.0000000000000005 | 24,128,680 | D061067:Antibodies, Monoclonal, Humanized; D001344:Autopsy; D001921:Brain; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal; D008875:Middle Aged; D009103:Multiple Sclerosis; D000069442:Natalizumab; D013116:Spinal Cord | Journal of neuropathology and experimental neurology | 2,013 | D061067:Antibodies, Monoclonal, Humanized; D000069442:Natalizumab |
Rituximab-induced acute lympholysis and pancytopenia after COVID-19 vaccination. | Rituximab and COVID-19 vaccine can cause massive hyperacute depletion of B cells and plasma cells, as well as subsequent cytokine release syndrome, coagulopathy, and pancytopenia. These effects differ from the adverse effects that have been reported for rituximab, and new guidelines regarding the timing of rituximab in... | 10.1002/ccr3.4517 | 34,429,981 | Clinical case reports | 2,021 | ||
Percutaneous Atrio-Ventricular Valve Interventions: Contemporary Advances and Remaining Challenges. | These are exciting exploratory times for structural/valvular heart interventions [...]. | 10.3390/jcm11164801 | 36,013,040 | Journal of clinical medicine | 2,022 | ||
Multi-sample dual-decoder graph autoencoder. | Self-supervised learning has shown superior performance on graph-related tasks in recent years. The most advanced methods are based on contrast learning, which severely limited by structured data augmentation techniques and complex training methods. Generative self-supervised learning, especially graph autoencoders (GA... | 10.1016/j.ymeth.2023.02.002 | 36,792,041 | D019985:Benchmarking; D003619:Dansyl Compounds; D005688:Galactosamine | Methods (San Diego, Calif.) | 2,023 | C079425:methyl-N-dansylgalactosaminide; D003619:Dansyl Compounds; D005688:Galactosamine |
Effects of naled and dichlorvos on growth and production of Luteoskyrin byPenicillium islandicum. | Two organophosphorus insecticides, 1, 2-dibromo -2, 2-dichloroethyl dimethyl phosphate (naled) and dimethyl 2, 2 -dichlorovinyl phosphate (dichlorvos) were used for investigation of their effects on growth and production of luteoskyrin mycotoxin byPenicillium islandicum in various cultural media at 25°C for 30 days or ... | 10.1007/BF03192230 | 23,606,065 | Mycotoxin research | 1,993 | ||
Dose-response study of oral famotidine for reduction of gastric acidity and volume in outpatients and inpatients. | A relatively new H2-antagonist, famotidine, has become clinically available, but its effectiveness in decreasing gastric acidity and volume has not been compared in inpatients and outpatients. We reexamined the difference in gastric acidity and volume in inpatients and outpatients, and tested the effectiveness of diffe... | 10.1213/00000539-199312000-00011 | 8,250,305 | D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D017558:Elective Surgical Procedures; D015738:Famotidine; D005744:Gastric Acid; D005745:Gastric Acidity Determination; D006760:Hospitaliza... | Anesthesia and analgesia | 1,993 | D015738:Famotidine |
Synthesis of 1,4-diphenylbutadiene derivatives: novel inducer of tissue-type plasminogen activator (t-PA) in cultured bovine endothelial cells. | (E,E)-1,4-Diphenylbutadiene derivatives were synthesized by utilizing the Stobbe reaction of dimethyl succinate as a key step. Their stereoisomers were also synthesized stereoselectively by means of the cross-coupling reaction of the vinylstannanes and the vinylbromides, which were obtained from the propiolic acid este... | 10.1248/cpb.54.1686 | 17,139,104 | D000818:Animals; D002070:Butadienes; D002417:Cattle; D042783:Endothelial Cells; D015394:Molecular Structure; D010960:Plasminogen Activators; D013329:Structure-Activity Relationship; D010959:Tissue Plasminogen Activator | Chemical & pharmaceutical bulletin | 2,006 | D002070:Butadienes; C012939:1,4-diphenylbutadiene; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator |
In vitro evaluation of chemical decontamination of titanium discs. | Peri-implant diseases are caused by bacterial biofilm colonizing implant surfaces. Prevention and management of peri-implant mucositis and peri-implantitis rely on effective biofilm removal. This study aimed to evaluate biofilm removal and cytocompatibility following chemo-mechanical surface decontamination of biofilm-... | 10.1038/s41598-021-02220-3 | 34,815,486 | Scientific reports | 2,021 | ||
Good's syndrome: brief overview of an enigmatic immune deficiency. | Good's syndrome, an infrequent adult-onset immunodeficiency is characterized by the triad of thymoma, hypogammaglobulinemia, and increased susceptibility to recurrent infections. The clinical presentation is highly variable, with a spectrum ranging from recurrent bacterial and opportunistic infections to concomitant au... | 10.1111/apm.13351 | 37,729,389 | D000328:Adult; D006801:Humans; D013945:Thymoma; D007153:Immunologic Deficiency Syndromes; D013953:Thymus Neoplasms; D000081207:Primary Immunodeficiency Diseases; D009894:Opportunistic Infections | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica | 2,023 | |
Compassion within conflict: Toward a computational theory of social groups informed by maternal brain physiology. | Benevolent intersubjectivity developed in parent-infant interactions and compassion toward friend and foe alike are non-violent interventions to group behavior in conflict. Based on a dyadic active inference framework rooted in specific parental brain mechanisms, we suggest that interventions promoting compassion and i... | 10.1017/S0140525X21001436 | 35,796,356 | D001921:Brain; D004645:Empathy; D006801:Humans; D007223:Infant | The Behavioral and brain sciences | 2,022 | |
Development of iBsafe: A Collaborative, Theory-based Approach to Creating a Mobile Game Application for Child Safety. | Unintentional injury is a leading cause of death worldwide, and the number one cause of child death in the United States. The American Academy of Pediatrics promotes safety recommendations to decrease child injury risk, however the majority of educational programs delivering these strategies are school-based or in comm... | 25,954,352 | D000818:Animals; D001642:Bicycling; D001733:Bites and Stings; D002648:Child; D002675:Child, Preschool; D004285:Dogs; D006801:Humans; D063731:Mobile Applications; D012449:Safety; D017216:Telemedicine; D014481:United States; D018910:Video Games; D014947:Wounds and Injuries | AMIA ... Annual Symposium proceedings. AMIA Symposium | 2,014 | ||
Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius). | Recent reports of elevated auditory thresholds in canaries of the Belgian Waterslager strain have shown that this strain has an inherited auditory deficit in which absolute auditory thresholds at high frequencies (i.e. above 2.0 kHz) are as much as 40 dB less sensitive than the thresholds of mixed-breed canaries and th... | 10.1016/0378-5955(94)90134-1 | 7,806,475 | D000161:Acoustic Stimulation; D000200:Action Potentials; D000818:Animals; D001299:Audiometry; D001309:Auditory Threshold; D001489:Basilar Membrane; D001715:Bird Diseases; D001947:Breeding; D002171:Canaries; D003051:Cochlea; D005260:Female; D006198:Hair Cells, Auditory; D006311:Hearing Disorders; D008297:Male; D008855:M... | Hearing research | 1,994 | |
Limit of miscibility and nanophase separation in associated mixtures. | We present a detailed analysis of the mixing process in an associating system, the water-tert-butanol (2-methyl-2-propanol) mixture. Using molecular dynamics simulations, together with neutron, X-ray diffraction experiments, and pulsed gradient spin-echo NMR, we study the local structure and dynamic properties over the... | 10.1021/jp3124499 | 23,937,163 | The journal of physical chemistry. B | 2,013 | ||
Peptidoglycan architecture of Gram-positive bacteria by solid-state NMR. | Peptidoglycan is an essential component of cell wall in Gram-positive bacteria with unknown architecture. In this review, we summarize solid-state NMR approaches to address some of the unknowns in the Gram-positive bacteria peptidoglycan architecture: 1) peptidoglycan backbone conformation, 2) PG-lattice structure, 3) ... | 24,915,020 | D000900:Anti-Bacterial Agents; D002473:Cell Wall; D006094:Gram-Positive Bacteria; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010457:Peptidoglycan; D013211:Staphylococcus aureus | Biochimica et biophysica acta | 2,015 | D000900:Anti-Bacterial Agents; D010457:Peptidoglycan | |
Characterization factors for terrestrial acidification at the global scale: a systematic analysis of spatial variability and uncertainty. | Characterization factors (CFs) are used in life cycle assessment (LCA) to quantify the potential impact per unit of emission. CFs are obtained from a characterization model which assess the environmental mechanisms along the cause-effect chain linking an emission to its potential damage on a given area of protection, s... | 25,226,072 | D000393:Air Pollutants; D000641:Ammonia; D004787:Environmental Pollution; D008962:Models, Theoretical; D009589:Nitrogen Oxides; D052638:Particulate Matter; D062206:Spatial Analysis; D013458:Sulfur Dioxide; D035501:Uncertainty | The Science of the total environment | 2,014 | D000393:Air Pollutants; D009589:Nitrogen Oxides; D052638:Particulate Matter; D013458:Sulfur Dioxide; D000641:Ammonia | |
β-N-Methylamino-L-Alanine Toxicity in PC12: Excitotoxicity vs. Misincorporation. | The implication of β-N-methylamino-L-alanine (BMAA) in the development of neurodegenerative diseases worldwide has led to several investigations of the mechanism, or mechanisms, of toxicity of this cyanobacterially produced amino acid. The primary mechanism of toxicity that was identified is excitotoxicity, with a seco... | 10.1007/s12640-017-9743-8 | 28,470,567 | D000599:Amino Acids, Diamino; D000818:Animals; D017304:Annexin A5; D017209:Apoptosis; D001120:Arginine; D001692:Biological Transport; D002172:Canavanine; D002454:Cell Differentiation; D049109:Cell Proliferation; D000087522:Cyanobacteria Toxins; D018690:Excitatory Amino Acid Agonists; D018698:Glutamic Acid; D053078:Memb... | Neurotoxicity research | 2,018 | D000599:Amino Acids, Diamino; D017304:Annexin A5; D000087522:Cyanobacteria Toxins; D018690:Excitatory Amino Acid Agonists; D010718:Phosphatidylserines; D017382:Reactive Oxygen Species; C001824:beta-N-methylamino-L-alanine; D002172:Canavanine; D018698:Glutamic Acid; D020932:Nerve Growth Factor; D001120:Arginine |
Management of symptomatic caliceal diverticular calculi: Minimally invasive percutaneous nephrolithotomy versus flexible ureterorenoscopy. | OBJECTIVE
To retrospectively evaluate appropriate treatment for patients with symptomatic caliceal diverticular calculi, by comparing the therapeutic outcomes for those undergoing minimally invasive percutaneous nephrolithotomy (MPCNL) and flexible ureterorenoscopy (F-URS).
METHODS
From March 2009 to May 2014, 36 con... | 10.1016/j.cdtm.2016.11.016 | 29,063,050 | Chronic diseases and translational medicine | 2,016 | ||
Neuronal expression and regulation of rat inhibitor of apoptosis protein-2 by kainic acid in the rat brain. | Inhibitors of apoptosis proteins (IAPs) define a protein family with the ability to counteract cell death by the inhibition of different caspases activated during apoptosis. These proteins are present in different cells, however, the function and roles of IAPs in brain tissue are not fully understood. We report here th... | 10.1046/j.0953-816x.2001.01847.x | 11,860,509 | D000818:Animals; D017209:Apoptosis; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; D015152:Blotting, Northern; D015153:Blotting, Western; D001921:Brain; D001923:Brain Chemistry; D053148:Caspase 3; D020169:Caspases; D002467:Cell Nucleus; D003001:Cloning, Molecular; D015342:DNA Probes; D018076:DNA, Complementary... | The European journal of neuroscience | 2,002 | D015342:DNA Probes; D018076:DNA, Complementary; D018690:Excitatory Amino Acid Agonists; D051034:Inhibitor of Apoptosis Proteins; D011506:Proteins; D012333:RNA, Messenger; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; C494836:Birc3 protein, rat; C505407:CASP3 protein, human; C505410:Casp3 protein, rat; D053148... |
Neck management in head and neck squamous cell carcinomas: where do we stand? | Head and neck squamous-cell carcinomas (HNSCCs) have a significant lymph node tropism. This varies considerably depending on the primary tumor site and the Human Papillomavirus (HPV) status of the disease. The best therapeutic option, between up-front lymph node dissection and chemoradiotherapy (CRT) +/- followed by ly... | 10.1007/s12032-019-1265-1 | 30,919,135 | D059248:Chemoradiotherapy; D019468:Disease Management; D006258:Head and Neck Neoplasms; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D037981:Neck Dissection; D009382:Neoplasms, Unknown Primary; D030361:Papillomavirus Infections; D000077195:Squamous Cell Carcinoma of Head and Neck | Medical oncology (Northwood, London, England) | 2,019 | |
Impaired baroreceptor control of renal sympathetic activity in human chronic heart failure. | BACKGROUND
The regulation of renal sympathetic activity in the setting of heart failure is largely unexplored. We used the norepinephrine spillover method to address the hypothesis that baroreflex control of renal sympathetic activity is blunted in heart failure.
METHODS AND RESULTS
Twenty-two patients were studied, ... | 10.1161/01.CIR.0000129313.73750.57 | 15,173,026 | D001794:Blood Pressure; D002302:Cardiac Output; D006333:Heart Failure; D006439:Hemodynamics; D006801:Humans; D006929:Hyperaldosteronism; D007668:Kidney; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009599:Nitroprusside; D009638:Norepinephrine; D011311:Pressoreceptors; D012021:Reflex, Abnormal; D012079:Renal ... | Circulation | 2,004 | D014665:Vasodilator Agents; D009599:Nitroprusside; D009638:Norepinephrine |
CUMC-6, a new diploid human cell line derived from a squamous carcinoma of the uterine cervix. | A new cell line, CUMC-6, has been derived from an invasive nonkeratinizing squamous cell carcinoma of the uterine cervix in a 31-year-old patient. It has been maintained in long-term culture for 61 months, and passaged over 300 times. Monolayer-cultured cells were polygonal in shape, showing a pavement-like arrangement... | 10.1006/gyno.1996.0221 | 8,751,555 | D000818:Animals; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell; D015342:DNA Probes; D004171:Diploidy; D005260:Female; D016259:Genes, myc; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008969:Molecular Sequence Data; D009154:Mutation; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014407:T... | Gynecologic oncology | 1,996 | D015342:DNA Probes; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone |
Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study. | BACKGROUND
Episodes of childhood convulsive status epilepticus (CSE) commonly start in the community. Treatment of CSE aims to minimise the length of seizures, treat the causes, and reduce adverse outcomes; however, there is a paucity of data on the treatment of childhood CSE. We report the findings from a systematic, ... | 10.1016/S1474-4422(08)70141-8 | 18,602,345 | D000293:Adolescent; D000927:Anticonvulsants; D002648:Child; D002675:Child, Preschool; D018672:Community Health Planning; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012111:Residence Characteristics; D012189:Retrospective S... | The Lancet. Neurology | 2,008 | D000927:Anticonvulsants |
Navigated vs arthroscopic-guided drilling for reconstruction of acromioclavicular joint injuries: accuracy and feasibility. | BACKGROUND
Anatomical reconstruction of the coracoclavicular ligaments is a relatively new technique for acromioclavicular (AC) joint injuries.
METHODS
Eighteen procedures (nine non-navigated, nine navigated) of anatomical reconstruction were performed minimally invasively, using the Tight Rope system, on cadaveric s... | 10.1002/rcs.1506 | 23,784,857 | D000173:Acromioclavicular Joint; D001182:Arthroscopy; D001864:Bone Wires; D002102:Cadaver; D005240:Feasibility Studies; D005471:Fluoroscopy; D006801:Humans; D021621:Imaging, Three-Dimensional; D004204:Joint Dislocations; D025321:Surgery, Computer-Assisted | The international journal of medical robotics + computer assisted surgery : MRCAS | 2,013 | |
Endoparasite infection hotspots in Estonian urban areas. | The human-animal bond is beneficial for human health, but companion animals also pose a potential threat as vectors of zoonotic parasites, especially in urban areas where both human and dog densities are high. However, the knowledge about parasitic spillover in the urban environment is relatively scarce. The aim of the... | 10.1017/S0022149X19000920 | 31,679,531 | D000818:Animals; D002947:Cities; D004283:Dog Diseases; D004285:Dogs; D004957:Estonia; D005260:Female; D007411:Intestinal Diseases, Parasitic; D008297:Male; D010271:Parasites | Journal of helminthology | 2,019 | |
Potential role of circular RNA in cyclosporin A-induced cardiotoxicity in rats. | Cyclosporin A (CsA) is a well-known and effective drug that is commonly used in autoimmune diseases and allotransplantation. However, kidney toxicity and cardiotoxicity limit its use. Circular RNAs (circRNAs) play a crucial role in disease, especially cardiovascular disease. We aimed to explore the circRNA expression p... | 10.1002/jat.4203 | 34,036,610 | D000818:Animals; D015415:Biomarkers; D066126:Cardiotoxicity; D016572:Cyclosporine; D015536:Down-Regulation; D006321:Heart; D007166:Immunosuppressive Agents; D008297:Male; D009206:Myocardium; D000079962:RNA, Circular; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation | Journal of applied toxicology : JAT | 2,022 | D015415:Biomarkers; D007166:Immunosuppressive Agents; D000079962:RNA, Circular; D016572:Cyclosporine |
[EPIDEMIOLOGICAL CHARACTERISTICS OF TETANUS IN THE REPUBLIC OF CROATIA]. | The aim of the study was to determine the epidemiological characteristics of tetanus in Croatia and to determine changes in the age and sex structure, morbidity and mortality after the introduction of mandatory immunization and after the introduction of additional immunization for persons aged ≥ 60. The retrospective s... | 30,091,887 | D017677:Age Distribution; D017523:Croatia; D006801:Humans; D017589:Immunization Programs; D015994:Incidence; D012189:Retrospective Studies; D017678:Sex Distribution; D013742:Tetanus; D013745:Tetanus Toxoid | Lijecnicki vjesnik | 2,016 | D013745:Tetanus Toxoid | |
Effects of training on Na, K-ATPase contents in skeletal muscle and K homeostasis of African draught bulls and cows. | In semiarid parts of Africa animal traction is still one of the most reliable sources for rural work power. However, draught animals have to produce most of their work power at an unfavourable moment of the year that is at the end of the dry season when feedlot is scare. To improve their condition prior to the planting... | 10.1111/j.1439-0442.2004.00663.x | 15,533,111 | D000818:Animals; D001706:Biopsy; D002417:Cattle; D005260:Female; D006706:Homeostasis; D008297:Male; D018482:Muscle, Skeletal; D010805:Physical Conditioning, Animal; D011188:Potassium; D012737:Sex Factors; D000254:Sodium-Potassium-Exchanging ATPase; D013997:Time Factors | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine | 2,004 | D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium |
The impact of internal control systems on the intensity of innovation and organizational performance of public sector organizations in Vietnam: the moderating role of transformational leadership. | Drawing on the resource-based view, new public management theory, and innovation systems theory, this study examines the relationships between internal control systems (ICSs) and organizational performance in Vietnamese public sector organizations (PSOs), with particular emphasis on the mediating role of intensity of i... | 10.1016/j.heliyon.2022.e08954 | 35,243,075 | Heliyon | 2,022 | ||
Aminolevulinic Acid-Photodynamic Therapy for Erosive Pustular Dermatosis of the Scalp: Comparison of Two Treatment Protocols and Participant Satisfaction. | Treatment of erosive pustular dermatosis of the scalp (EPDS) is challenging. Topical and systemic medications have achieved limited success, and destructive modalities have been associated with EPDS recurrence because of the tendency of the condition to recur after any treatment that induces trauma to the skin. Our gro... | 35,532,762 | D000622:Aminolevulinic Acid; D002985:Clinical Protocols; D006801:Humans; D010549:Personal Satisfaction; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D012535:Scalp; D012536:Scalp Dermatoses | Skinmed | 2,022 | D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid | |
Pharmacological Study of A3 Adenosine Receptor agonist (AB Meca) in Xenograft Lung Cancer Model in Mice through In Silico and In Vivo Approach: Targeting TNF-α. | BACKGROUND
Lung cancer is the leading cause of mortality in India. Adenosine Receptor (AR) has emerged as a novel cancer-specific target. A3AR levels are upregulated in various tumor cells, which may mean that the specific AR may act as a biological marker and target specific ligands leading to cell growth inhibition.
... | 10.2174/1570163818666210810142022 | 35,135,461 | D000241:Adenosine; D058909:Adenosine A3 Receptor Agonists; D000818:Animals; D004195:Disease Models, Animal; D004317:Doxorubicin; D064593:Heterografts; D006801:Humans; D008175:Lung Neoplasms; D051379:Mice; D062105:Molecular Docking Simulation; D051381:Rats; D014409:Tumor Necrosis Factor-alpha | Current drug discovery technologies | 2,022 | D058909:Adenosine A3 Receptor Agonists; D014409:Tumor Necrosis Factor-alpha; C046756:5'-N-methylcarboxamideadenosine; D004317:Doxorubicin; D000241:Adenosine |
Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. | We hypothesized that genes expressed in pancreatic acinar cells during the initiation of acute pancreatitis determine the severity of the disease. Therefore, we utilized microarrays to identify those genes commonly induced in rat pancreatic acinar cells within 1-4 h in two in vivo models, caerulein and taurocholate adm... | 10.1152/physiolgenomics.00174.2002 | 12,709,512 | D000208:Acute Disease; D000818:Animals; D002478:Cells, Cultured; D002108:Ceruletide; D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D017874:Immediate-Early Proteins; D007249:Inflammation; D008297:Male; D010179:Pancreas; D0101... | Physiological genomics | 2,003 | D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D017874:Immediate-Early Proteins; D014157:Transcription Factors; D013656:Taurocholic Acid; D002108:Ceruletide |
Leukaemogenesis in Down's syndrome. | Due to the fixed karyotype and documented malignancy risk in patients with Down's syndrome, recently described aetiological factors can be assigned to their proper places in a conceptual framework for leukaemogenesis in these individuals. This is a more profitable approach than those in which various types of karyotypi... | 138,950 | D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002904:Chromosomes, Human, 21-22 and Y; D004314:Down Syndrome; D006801:Humans; D007153:Immunologic Deficiency Syndromes; D007223:Infant; D007938:Leukemia; D012190:Retroviridae; D014777:Virus Diseases | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde | 1,977 | ||
Comparative Sorption Properties of Metal(III) Phosphates. | Sorptionbehavior of metal(III) phosphates toward Zn(2+) was investigated using different concentrations, pHs, and temperatures. Ion exchange between protons from the surface and metal cations from solutions was found to be responsible for metal sorption by metal(III) phosphates. Dissociation constants of metal(III) pho... | 10.1006/jcis.1999.6429 | 10,550,241 | Journal of colloid and interface science | 1,999 | ||
Exercise-induced loss of bone density in athletes. | In athletes, the rarely identified malady of osteoporosis differs from other chronic effects of exercise. The most obvious difference is that hormonal imbalance leads to compensatory mechanisms that in turn lead to osteoporosis and increased incidence of fracture. Most research on this subject has dealt with women, bec... | 10.5435/00124635-199811000-00003 | 9,826,418 | D000293:Adolescent; D000328:Adult; D015519:Bone Density; D016723:Bone Remodeling; D002136:Calcium, Dietary; D015444:Exercise; D005260:Female; D012739:Gonadal Steroid Hormones; D006801:Humans; D008297:Male; D008875:Middle Aged; D009751:Nutritional Requirements; D010024:Osteoporosis; D012307:Risk Factors; D013177:Sports | The Journal of the American Academy of Orthopaedic Surgeons | 1,998 | D002136:Calcium, Dietary; D012739:Gonadal Steroid Hormones |
The detection of Vero cytotoxin-producing Escherichia coli and Shigella dysenteriae type 1 in faecal specimens using polymerase chain reaction gene amplification. | Fifty consecutive faecal specimens received by the LEP were examined for the presence of Vero cytotoxin (VT) genes by polymerase chain reaction (PCR) gene amplification. Nineteen were positive by PCR and from 16 of these, VT positive Escherichia coli O157 were isolated. The remaining three samples were positive for VT ... | 10.1111/j.1472-765x.1994.tb00968.x | 7,765,704 | D001427:Bacterial Toxins; D001483:Base Sequence; D003603:Cytotoxins; D015342:DNA Probes; D004269:DNA, Bacterial; D003967:Diarrhea; D004405:Dysentery, Bacillary; D004926:Escherichia coli; D004927:Escherichia coli Infections; D005243:Feces; D005798:Genes, Bacterial; D006463:Hemolytic-Uremic Syndrome; D006801:Humans; D008... | Letters in applied microbiology | 1,994 | D001427:Bacterial Toxins; D003603:Cytotoxins; D015342:DNA Probes; D004269:DNA, Bacterial; D022622:Shiga Toxin 1 |
A video questionnaire identifies upper airway abnormalities in preschool children with reported wheeze. | BACKGROUND
Accurate characterisation of subjects is essential to interpret data from studies investigating preschool wheezing.
AIM
To assess whether a video questionnaire (VQ) identifies upper airway abnormalities in preschool children with reported wheeze.
METHODS
Forty three children (median age 17 months, range ... | 10.1136/adc.2004.071134 | 15,855,176 | D000402:Airway Obstruction; D001999:Bronchoscopy; D002675:Child, Preschool; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D007223:Infant; D008297:Male; D010290:Parents; D012135:Respiratory Sounds; D012140:Respiratory Tract Diseases; D011795:Surveys and Questionnaires; D014743:Videotape Recording | Archives of disease in childhood | 2,005 | |
A Bayesian approach for incorporating economic factors in sample size design for clinical trials of individual drugs and portfolios of drugs. | Classical approaches to clinical trial design ignore economic factors that determine economic viability of a new drug. We address the choice of sample size in Phase III trials as a decision theory problem using a hybrid approach that takes a Bayesian view from the perspective of a drug company and a classical Neyman-Pe... | 10.1002/sim.2955 | 17,579,924 | D001499:Bayes Theorem; D002986:Clinical Trials as Topic; D003661:Decision Support Techniques; D016527:Drug Costs; D006801:Humans; D018803:Models, Economic; D012107:Research Design; D018401:Sample Size | Statistics in medicine | 2,007 | |
Sudden death in epilepsy: standards of reporting and the value of toxicological analysis. | The authors audited the value of toxicology/histology and reporting standards in sudden death autopsy cases in individuals with epilepsy/seizures. Of 83 cases with epilepsy/seizures and no macroscopically obvious cause of death, 40 had no history of drug/alcohol abuse. Toxicological analysis was performed in 11/40 (28%... | 10.1136/jclinpath-2011-200109 | 22,021,565 | D001344:Autopsy; D003645:Death, Sudden; D004827:Epilepsy; D019983:Guideline Adherence; D006801:Humans; D008485:Medical Audit; D017410:Practice Guidelines as Topic; D011364:Professional Practice; D014116:Toxicology | Journal of clinical pathology | 2,011 | |
Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain. | The alpha(2)beta(1) integrin supports cell-cycle progression of mammary epithelial cells adherent to type I collagen matrices. Integrin collagen receptors containing the alpha(2) cytoplasmic domain stimulated expression of cyclin E and cyclin-dependent kinase (cdk)2, resulting in cyclin E/cdk2 activation in the absence... | 10.1016/s0002-9440(10)61774-9 | 11,549,591 | D001940:Breast; D042846:CDC2-CDC28 Kinases; D002453:Cell Cycle; D003094:Collagen; D019927:Cyclin E; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases; D003593:Cytoplasm; D004357:Drug Synergism; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D016023:Integrins; D017346:Protein Serine-Threonin... | The American journal of pathology | 2,001 | D019927:Cyclin E; D016023:Integrins; D038981:Receptors, Collagen; D003094:Collagen; D011972:Receptor, Insulin; D017346:Protein Serine-Threonine Kinases; D042846:CDC2-CDC28 Kinases; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases |
Development of targeted gene transfer into human primary T lymphocytes and macrophages using high-titer recombinant HIV vectors. | Primary human lymphocytes and macrophages are an important target cells for human immunodeficiency virus (HIV). For targeted gene transfer into CD4(+) lymphocytes and macrophages, we constructed HIV vectors with envelope glycoprotein (gp120) from the T-cell tropic BH10 strain and the macrophage tropic SF162, and develo... | 10.1016/j.jbiotec.2007.01.004 | 17,307,270 | D015496:CD4-Positive T-Lymphocytes; D004274:DNA, Recombinant; D005434:Flow Cytometry; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D049452:Green Fluorescent Proteins; D006678:HIV; D015699:HIV Envelope Protein gp120; D006367:HeLa Cells; D006801:Humans; D0082... | Journal of biotechnology | 2,007 | D004274:DNA, Recombinant; D015699:HIV Envelope Protein gp120; D049452:Green Fluorescent Proteins |
Analysis of an IL-10 polymorphism in idiopathic pulmonary fibrosis. | Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic disorder of the lung parenchyma. We have demonstrated changes in IL-10 protein production by alveolar macrophages (AMs) from patients with IPF, which we hypothesise could be because of an IL-10 gene polymorphism. We have screened the coding sequence ... | 10.1038/sj.gene.6363959 | 12,761,561 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D005260:Female; D006801:Humans; D016753:Interleukin-10; D008297:Male; D008875:Middle Aged; D009154:Mutation; D018807:Polymorphism, Single-Stranded Conformational; D011658:Pulmonary Fibrosis | Genes and immunity | 2,003 | D016753:Interleukin-10 |
Designing benzosiloles for better optoelectronic properties using DFT & TDDFT approaches. | Like siloles, benzosiloles have low lying LUMOs due to σ*-π* conjugation between Si and the butadiene moiety but are more amenable for structural tuning. In total, 27 benzosiloles, 12 of them already synthesized and another 15 newly reported here, have been investigated using DFT and TDDFT calculations with an aim to c... | 10.1039/c2cp41554b | 22,847,369 | Physical chemistry chemical physics : PCCP | 2,012 | ||
Determination of Work Related to Endoscopic Decompression of Lumbar Spinal Stenosis. | Background: Effective 1 January 2017, single-level endoscopic lumbar discectomy received a Category I Current Procedural Terminology (CPT®) code 62380. However, no work relative value units (wRVUs) are currently assigned to the procedure. A physician's payment needs to be updated to commensurate with the work involved ... | 10.3390/jpm13040614 | 37,109,000 | Journal of personalized medicine | 2,023 | ||
The Transplantation Ecosystem: A New Concept to Improve Access and Outcomes for Older Allogeneic Hematopoietic Cell Transplantation Patients. | Allogeneic hematopoietic cell transplantation (HCT) is increasingly offered to older adults with hematologic malignancies, even though nonrelapse mortality remains a major concern in older patients owing to more comorbidities and greater frailty compared with their younger counterparts. The importance of patient fitnes... | 10.1016/j.jtct.2023.04.020 | 37,137,442 | Transplantation and cellular therapy | 2,023 | ||
Tissue-type plasminogen activator, a new prognostic marker in breast cancer. | Plasminogen activator is a protease existing in two forms known as tissue-type and urokinase-type plasminogen activator. In this investigation, patients with breast cancers containing high levels of the tissue-type enzyme had a significantly longer disease-free interval and survival compared with patients with low leve... | 3,124,957 | D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D011379:Prognosis; D011959:Receptors, Estradiol; D010959:Tissue Plasminogen Activator | Cancer research | 1,988 | D011959:Receptors, Estradiol; D010959:Tissue Plasminogen Activator | |
2-(1,2,3,4-Tetra-hydro-9H-carbazol-1-yl-idene)propane-dinitrile. | In the title compound, C(15)H(11)N(3), the cyclo-hexene ring adopts a sofa conformation. An intra-molecular N-H⋯N hydrogen bond generates an S(7) ring motif. In the crystal, mol-ecules are linked by inter-molecular N-H⋯N, C-H⋯N and C-H⋯π inter-actions into a three-dimensional network. | 10.1107/S1600536810042649 | 21,589,132 | Acta crystallographica. Section E, Structure reports online | 2,010 | ||
High-fat diet blunts activation of the nuclear factor-κB signaling pathway in lipopolysaccharide-stimulated peritoneal macrophages of Wistar rats. | OBJECTIVE
The present study was designed to investigate the effect of a high-fat diet (HFD) on the inflammatory response of peritoneal macrophages.
METHODS
Male Wistar rats were fed a control diet (n = 12) or an HFD (n = 12) for 12 wk. After euthanasia, peritoneal macrophages were collected and stimulated (or not) wi... | 23,085,013 | D000818:Animals; D015415:Biomarkers; D002478:Cells, Cultured; D059305:Diet, High-Fat; D015536:Down-Regulation; D007249:Inflammation; D007333:Insulin Resistance; D016753:Interleukin-10; D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D017737:Macrophages, Peritoneal; D008297:Male; D016328:N... | Nutrition (Burbank, Los Angeles County, Calif.) | 2,013 | D015415:Biomarkers; D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D016328:NF-kappa B; D017395:Plasminogen Activator Inhibitor 1; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D009569:Nitric Oxide | |
Hydrogen-bonded co-crystal structure of benzoic acid and zwitterionic l-proline. | The title compound [systematic name: benzoic acid-pyrrolidin-1-ium-2-carboxyl-ate (1/1)], C7H6O2·C5H9NO2, is an example of the application of non-centrosymmetric co-crystallization for the growth of a crystal containing a typically centrosymmetric component in a chiral space group. It co-crystallizes in the space group... | 10.1107/S2056989017001785 | 28,316,811 | Acta crystallographica. Section E, Crystallographic communications | 2,017 | ||
The Presence of Uveitis Is Associated with a Sustained Response to the Interleukin (IL)-1 Inhibitors Anakinra and Canakinumab in Behçet's Disease. | Purpose: To identify factors associated with sustained response to interleukin (IL)-1 inhibition among demographic, clinical and therapeutic data in patients with Behçet disease (BD).Methods: BD patients treated with anakinra or canakinumab were enrolled. Patients were divided into two groups according to the clinical ... | 10.1080/09273948.2018.1511810 | 30,148,652 | D000328:Adult; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D001528:Behcet Syndrome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D008297:Male; D012189:Retrospective Studies; D014605:Uveitis | Ocular immunology and inflammation | 2,020 | D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; C541220:canakinumab |
Anticoagulation and platelet antiaggregation therapy in stroke prevention. | PURPOSE OF REVIEW
The results of recent large clinical trials have modified treatment plans formerly based on inferred mechanisms of ischemic stroke and hazards of certain forms of therapy.
RECENT FINDINGS
Strong data have emerged to support anticoagulation with warfarin for stroke associated with inferred embolism i... | 10.1097/00019052-200502000-00011 | 15,655,403 | D000925:Anticoagulants; D016736:Antiphospholipid Syndrome; D001281:Atrial Fibrillation; D002986:Clinical Trials as Topic; D006344:Heart Septal Defects, Atrial; D006801:Humans; D010975:Platelet Aggregation Inhibitors; D012008:Recurrence; D012307:Risk Factors; D020521:Stroke; D014859:Warfarin | Current opinion in neurology | 2,005 | D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D014859:Warfarin |
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