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Machine Learning Using Multiparametric Magnetic Resonance Imaging Radiomic Feature Analysis to Predict Ki-67 in World Health Organization Grade I Meningiomas. | BACKGROUND
Although World Health Organization (WHO) grade I meningiomas are considered "benign" tumors, an elevated Ki-67 is one crucial factor that has been shown to influence tumor behavior and clinical outcomes. The ability to preoperatively discern Ki-67 would confer the ability to guide surgical strategy.
OBJECT... | 10.1093/neuros/nyab307 | 34,460,921 | D006801:Humans; D019394:Ki-67 Antigen; D000069550:Machine Learning; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms; D008579:Meningioma; D000081364:Multiparametric Magnetic Resonance Imaging; D012189:Retrospective Studies | Neurosurgery | 2,021 | D019394:Ki-67 Antigen |
Echocardiographic evaluation of left ventricular function before and after cardioversion of atrial fibrillation to normal sinus rhythm. | Echocardiographic measurements were obtained in 20 patients before cardioversion immediately after and two, four and six hours after cardioversion to normal sinus rhythm. At six hours after cardioversion there was no significant change in heart rate, left atrial diameters (LAD), left ventricular end-diastolic diameters... | 6,658,341 | D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation; D004452:Echocardiography; D004554:Electric Countershock; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D016276:Ventricular Function | Medecine interne | 1,983 | ||
Morphine and the "lytic cocktail" for terminally ill patients in a French general hospital: evidence for an inverse relationship. | Undertreatment of cancer pain with analgesic drugs is still a frequent problem in French hospitals. In the absence of good analgesic practices, the use of a so-called lytic cocktail, which combines a neuroleptic (chlorpromazine), an opioid (meperidine), and an antihistamine (promethazine) has become common during the t... | 10.1016/0885-3924(95)00002-G | 7,541,434 | D000368:Aged; D002746:Chlorpromazine; D016638:Critical Illness; D004338:Drug Combinations; D005260:Female; D005602:France; D006769:Hospitals, General; D006801:Humans; D008297:Male; D008614:Meperidine; D009020:Morphine; D010166:Palliative Care; D011398:Promethazine | Journal of pain and symptom management | 1,995 | D004338:Drug Combinations; D009020:Morphine; D008614:Meperidine; D011398:Promethazine; D002746:Chlorpromazine |
Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors. | INTRODUCTION
Hypoxic tumors overexpress two carbonic anhydrases (CA, EC 4.2.1.1), CA IX and XII, involved in complex processes connected to tumorigenesis (pH regulation, metabolism, invasion, and dissemination of the tumor). The biochemical rationale behind these processes is orchestrated by the transcription factor hy... | 10.1080/13543784.2018.1548608 | 30,426,805 | D000818:Animals; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D000071231:Carbonic Anhydrase IX; D002257:Carbonic Anhydrase Inhibitors; D002256:Carbonic Anhydrases; D015195:Drug Design; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D009369:Neoplasms; D000072258:Tumor Hypoxia | Expert opinion on investigational drugs | 2,018 | D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D002257:Carbonic Anhydrase Inhibitors; D051793:Hypoxia-Inducible Factor 1; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases; C477378:carbonic anhydrase XII |
Improved care for patients with congestive heart failure. | BACKGROUND
Congestive heart failure (CHF) affects 4.9 million people, mostly elderly, in the United States; 550,000 new cases are diagnosed each year. Evidence-based treatment approaches offer opportunities to reduce mortality, complications, and rehospitalization rates.
STRATEGIES TO IMPROVE CARE FOR PATIENTS WITH C... | 10.1016/s1553-7250(08)34003-3 | 18,277,797 | D000359:Aftercare; D019317:Evidence-Based Medicine; D005190:Family; D015438:Health Behavior; D006293:Health Promotion; D006333:Heart Failure; D006761:Hospitals; D006801:Humans; D009937:Organizational Objectives; D010351:Patient Discharge; D010358:Patient Participation; D010360:Patient Transfer; D011785:Quality Assuranc... | Joint Commission journal on quality and patient safety | 2,008 | |
Transition-Metal-Free Deconstructive Lactamization of Piperidines. | One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3 )-C(sp3 ) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalyst... | 10.1002/anie.201903880 | 30,998,837 | Angewandte Chemie (International ed. in English) | 2,019 | ||
Involvement of gangliosides in glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule TAG-1 signaling in lipid rafts. | The association of ganglioside GD3 with TAG-1, a glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule, was examined by coimmunoprecipitation experiments. Previously, we have shown that the anti-ganglioside GD3 antibody (R24) immunoprecipitated the Src family kinase Lyn from the rat cerebellum, and R24 ... | 10.1074/jbc.M003163200 | 10,944,523 | D000818:Animals; D001483:Base Sequence; D015816:Cell Adhesion Molecules, Neuronal; D002478:Cells, Cultured; D058969:Contactin 2; D017931:DNA Primers; D005732:Gangliosides; D017261:Glycosylphosphatidylinositols; D006868:Hydrolysis; D008562:Membrane Glycoproteins; D011233:Precipitin Tests; D051381:Rats; D015398:Signal Tr... | The Journal of biological chemistry | 2,000 | D015816:Cell Adhesion Molecules, Neuronal; C548676:Cntn2 protein, rat; D058969:Contactin 2; D017931:DNA Primers; D005732:Gangliosides; D017261:Glycosylphosphatidylinositols; D008562:Membrane Glycoproteins; C026226:ganglioside, GD3 |
Knowledge sharing behaviour and intensive care nurse innovation: the moderating role of control of care quality. | AIMS
This study investigates the influence of intensive care unit nurses' knowledge sharing behaviour on nurse innovation, given different conditions of care quality control.
BACKGROUND
Health-care organisations face an increasing pressure to innovate while controlling care quality. We have little insight on how the ... | 10.1111/jonm.12404 | 27,271,179 | D001291:Attitude of Health Personnel; D003422:Critical Care; D006801:Humans; D033181:Information Dissemination; D007400:Interprofessional Relations; D019359:Knowledge; D009426:Netherlands; D009726:Nurses; D009936:Organizational Innovation; D011787:Quality of Health Care; D011795:Surveys and Questionnaires | Journal of nursing management | 2,016 | |
[Nutrition in sports]. | A sports diet is qualitatively similar to a diet of a healthy adult. Its main aspects are meeting the energy and fluid requirements, which in contrast to sedentary people can vary to a large degree in sportsmen. The relative contribution of the macronutrients to the energy consumption should make up 55 to 60% carbohydr... | 10.1024/0040-5930.57.3.110 | 10,756,689 | D000328:Adult; D002149:Energy Intake; D004734:Energy Metabolism; D006801:Humans; D009751:Nutritional Requirements; D013177:Sports; D014882:Water-Electrolyte Balance | Therapeutische Umschau. Revue therapeutique | 2,000 | |
[Toward zero mortality in liver resection. Presentation of 200 consecutive cases]. | INTRODUCTION
Liver resection (LR) morbidity and mortality rates have dropped in recent decades. Mortality is now below 5% and morbidity is less than 30%. Our objective was to present a series of 200 LRs without mortality and to analyze the factors that may be related to complications.
PATIENTS AND METHOD
Between Janu... | 10.1016/s0009-739x(05)70879-4 | 16,420,786 | D001650:Bile Duct Neoplasms; D002277:Carcinoma; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate | Cirugia espanola | 2,005 | |
Association of bilateral lower limb coordination while standing with body sway control and aging. | PURPOSE
Coordinated movements of both lower limbs may be a clinically important indicator of motor control during quiet standing. From a neurological point of view, it is known that extensive coupling of muscles must be coordinated an upright posture. However, movement coordination between the lower limbs is the final ... | 10.1080/08990220.2021.1973402 | 34,496,708 | D000368:Aged; D000375:Aging; D006801:Humans; D035002:Lower Extremity; D009068:Movement; D004856:Postural Balance; D055815:Young Adult | Somatosensory & motor research | 2,021 | |
Atypical ulnar tunnel syndrome accompanied by sensory disturbance of the dorsal sensory branch of the ulnar nerve. | An atypical accessory abductor digiti minimi, which is morphologically a bicipital muscle, was the cause of the ulnar tunnel syndrome. A ganglion grew from the volar carpal joint at the same time and caused sensory disturbance of the dorsal sensory branch of the ulnar nerve. | 10.1080/02844310701384017 | 19,308,864 | D005260:Female; D006801:Humans; D008875:Middle Aged; D014459:Ulnar Nerve; D017769:Ulnar Nerve Compression Syndromes | Scandinavian journal of plastic and reconstructive surgery and hand surgery | 2,009 | |
Severe vancomycin-induced anaphylactic reaction. | Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome... | 20,234,160 | D000284:Administration, Oral; D000328:Adult; D000707:Anaphylaxis; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus; D008775:Methylprednisolone; D008875:Middle... | Medicina (Kaunas, Lithuania) | 2,010 | D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D014640:Vancomycin; D011239:Prednisolone; D008775:Methylprednisolone | |
Molecular connectivity in quantitative structure--activity relationship study of anesthetic and toxic activity of aliphatic hydrocarbons, ethers, and ketones. | The nonempirical molecular connectivity indexes of 27 aliphatic hydrocarbons, ethers, and ketones were calculated. Very good correlations were obtained between anesthetic (AD100) and toxic (LD100 and LD50) activities of these compounds and their molecular connectivity indexes. These quantitative structure--activity rel... | 10.1002/jps.2600670437 | 641,775 | D000777:Anesthetics; D000818:Animals; D004987:Ethers; D006838:Hydrocarbons; D007659:Ketones; D007928:Lethal Dose 50; D051379:Mice; D013329:Structure-Activity Relationship | Journal of pharmaceutical sciences | 1,978 | D000777:Anesthetics; D004987:Ethers; D006838:Hydrocarbons; D007659:Ketones |
A novel tricyanoruthenium(III) building block for the construction of bimetallic coordination polymers. | Reaction of excess cyanide with a ruthenium(VI) nitrido complex bearing a tridentate Schiff base ligand produces a novel tricyanoruthenium(III) complex in which nucleophilic substitution of an imine hydrogen of the Schiff base by cyanide has occurred, this complex is a useful building block for the construction of 3d-R... | 10.1039/c001732a | 20,657,944 | Chemical communications (Cambridge, England) | 2,010 | ||
Sternal metastasis of breast cancer: ex vivo hypothermia and reimplantation. | Breast cancer frequently metastasizes to the bone. When the sternum is involved, it usually presents as a solitary lesion. In such cases, resection is indicated, including with the intention to cure. This case report describes a technique for a complete exeresis of the sternum, ex vivo repair under hypothermia, and rei... | 10.1016/j.athoracsur.2010.08.029 | 21,256,319 | D000971:Antineoplastic Combined Chemotherapy Protocols; D001707:Biopsy, Needle; D001859:Bone Neoplasms; D001943:Breast Neoplasms; D018270:Carcinoma, Ductal, Breast; D017024:Chemotherapy, Adjuvant; D003452:Cryosurgery; D003520:Cyclophosphamide; D004317:Doxorubicin; D005260:Female; D005472:Fluorouracil; D005500:Follow-Up... | The Annals of thoracic surgery | 2,011 | D013629:Tamoxifen; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil |
Effects of metformin treatment on pregnancy outcomes in patients with polycystic ovary syndrome. | INTRODUCTION
This review covers the current evidence regarding the use of metformin as a therapeutic intervention for optimizing pregnancy outcomes in women with polycystic ovary syndrome (PCOS).
AREAS COVERED
After searching Medline, Embase and CINAHL, all important large clinical trials and observational studies pl... | 10.1080/17446651.2021.1889366 | 33,634,727 | D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents; D050498:Live Birth; D008687:Metformin; D011085:Polycystic Ovary Syndrome; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate | Expert review of endocrinology & metabolism | 2,021 | D007004:Hypoglycemic Agents; D008687:Metformin |
Honoring DEI Requires a New Ethic and a New Science. | Systemic change requires complex conceptual and practical efforts from organizations and individuals alike. In forensic psychiatry, improving the experiences of marginalized groups respects the personhood and dignity of those who have been neglected over time and promises improvements in outcomes that have been affecte... | 10.29158/JAAPL.230090-23 | 38,065,617 | The journal of the American Academy of Psychiatry and the Law | 2,023 | ||
Addition of n-butyllithium to an aldimine: role of chelation, aggregation, and cooperative solvation. | Rate studies of the addition of n-BuLi in the presence of TMEDA to potentially chelating aldimines are consistent with a combination of monomer- and dimer-based mechanisms. Using mixtures of TMEDA and Et2O reveals cooperative solvation in which both Et2O and TMEDA coordinate to lithium at the monomer- and dimer-based t... | 10.1021/ja0519987 | 16,076,174 | Journal of the American Chemical Society | 2,005 | ||
Diffuse striated muscle heteroplasia of the lung. An autopsy case. | We studied a diffuse, striated muscle heteroplasia in the lungs in a 20-week-old stillborn fetus. The lung was small, but retained normal shape. There was no tumefaction. Histologically, a massive and diffuse distribution of the striated muscle cells was found among the interstitia of the dysplastic lung, representing ... | 6,897,173 | D005260:Female; D005313:Fetal Death; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases; D008168:Lung; D008175:Lung Neoplasms; D008297:Male; D009132:Muscles; D011247:Pregnancy; D012208:Rhabdomyosarcoma | Archives of pathology & laboratory medicine | 1,982 | ||
Patellar impingement against the tibial component after total knee arthroplasty. | Patella baja developed in seven knees in five patients after posterior stabilized total knee arthroplasties when the patella became impinged against the tibial component. Patellar replacement was performed in four knees, and all patients were able to achieve deep flexion postoperatively. The mean followup was 50 months... | 10.1097/01.blo.0000224049.56130.86 | 16,760,804 | D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D006801:Humans; D007592:Joint Diseases; D008297:Male; D010329:Patella; D013977:Tibia | Clinical orthopaedics and related research | 2,006 | |
Induction of connective tissue by various alloplastic materials: an experimental study in rats. | The capacity of three alloplastic implant materials to induce connective tissue was tested on the backs of 19 rats. A standardized viscous sponge served as control material. The commercial implant materials studied were carbon fibre and polypropylene ligament prostheses and a sponge composite of polytetrafluorethylene ... | 10.1016/0142-9612(89)90093-8 | 2,478,207 | D000818:Animals; D002244:Carbon; D003094:Collagen; D003238:Connective Tissue; D004247:DNA; D006595:Hexosamines; D006909:Hydroxyproline; D008297:Male; D008422:Materials Testing; D011126:Polypropylenes; D011138:Polytetrafluoroethylene; D011428:Proplast; D019736:Prostheses and Implants; D012313:RNA; D051381:Rats; D011919:... | Biomaterials | 1,989 | D006595:Hexosamines; D011126:Polypropylenes; D011428:Proplast; D012313:RNA; D002244:Carbon; D011138:Polytetrafluoroethylene; D003094:Collagen; D004247:DNA; D006909:Hydroxyproline |
C/EBPdelta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution. | The STAT3 transcription factor is an important initiator of mammary gland involution in the mouse. This work shows that the STAT3 target gene CCAAT/enhancer binding protein delta (C/EBPdelta) is a crucial mediator of pro-apoptotic gene expression events in mammary epithelial cells. In the absence of C/EBPdelta, involut... | 10.1242/dev.02050 | 16,192,306 | D000818:Animals; D017209:Apoptosis; D051743:CCAAT-Enhancer-Binding Protein-delta; D051152:Clusterin; D019938:Cyclin D1; D004847:Epithelial Cells; D005260:Female; D005786:Gene Expression Regulation; D018975:Insulin-Like Growth Factor Binding Protein 5; D008321:Mammary Glands, Animal; D051379:Mice; D008817:Mice, Mutant S... | Development (Cambridge, England) | 2,005 | D051152:Clusterin; D018975:Insulin-Like Growth Factor Binding Protein 5; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1; D051743:CCAAT-Enhancer-Binding Protein-delta |
Using real-time ultrasound imaging as adjunct teaching tools to enhance physical therapist students' ability and confidence to perform traction of the knee joint. | Often, physical therapy students struggle with the skill and the confidence to perform manual techniques for musculoskeletal examination. Current teaching methods lack concurrent objective feedback. Real-time ultrasound imaging (RTUI) has the advantage of generating visualization of anatomical structures in real-time i... | 10.1016/j.msksp.2018.01.005 | 29,358,105 | D000328:Adult; D002983:Clinical Competence; D004504:Education, Medical, Undergraduate; D005260:Female; D006801:Humans; D007718:Knee Injuries; D008297:Male; D010808:Physical Examination; D059825:Physical Therapists; D013337:Students, Medical; D014143:Traction; D014463:Ultrasonography; D055815:Young Adult | Musculoskeletal science & practice | 2,018 | |
Morphological features of principal cells in the ovine epididymis: a quantitative and qualitative study. | Functions of the epididymis differ by region, and this may be reflected in epithelial structure. Therefore, tissues from the initial segment (IS), proximal and central caput (PCap, CCap), and proximal and central corpus (PCor, CCor) epididymidis were examined by light and transmission electron microscopy. The proportio... | 10.1095/biolreprod42.1.167 | 2,310,815 | D000818:Animals; D004721:Endoplasmic Reticulum; D004822:Epididymis; D004847:Epithelial Cells; D004848:Epithelium; D006056:Golgi Apparatus; D008297:Male; D012756:Sheep | Biology of reproduction | 1,990 | |
Annealed Ising model with site dilution on self-similar structures. | We consider an Ising model on the triangular Apollonian network (AN), with a thermalized distribution of vacant sites. The statistical problem is formulated in a grand canonical ensemble, in terms of the temperature T and a chemical potential μ associated with the concentration of active magnetic sites. We use a well-k... | 10.1103/PhysRevE.90.052112 | 25,493,745 | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,014 | ||
[Fact-finding survey on regional healthcare services for patients with epilepsy based on a questionnaire administered to public health centers in Japan]. | OBJECTIVES
Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. The prevalence of epilepsy is about 1%, and its incidence is increasing with the aging population. In addition to their medical problems, epilepsy patients face many social problems, including schooling, workin... | 10.11236/jph.62.10_609 | 26,607,920 | D004827:Epilepsy; D006801:Humans; D007564:Japan; D011637:Public Health Nursing; D012040:Regional Health Planning; D012947:Social Work; D011795:Surveys and Questionnaires | [Nihon koshu eisei zasshi] Japanese journal of public health | 2,015 | |
Parotid salivary secretion induced by stimulation of periodontal regions with toothbrush in humans. | The act of brushing teeth induces salivary secretion. However, there is no evidence to show which particular regions of the teeth and oral cavity in brushing induces the most effective salivary secretion. We investigated the effects of tooth brushing in different oral regions on parotid salivary secretion in humans. Sa... | 10.2152/jmi.56.277 | 20,224,201 | D005881:Gingiva; D006801:Humans; D008465:Mechanoreceptors; D009055:Mouth; D010159:Palate; D010306:Parotid Gland; D010519:Periodontium; D012463:Saliva; D014059:Tongue; D014070:Tooth; D014099:Toothbrushing | The journal of medical investigation : JMI | 2,009 | |
Socioeconomic status does not affect prognosis in patients with glioblastoma multiforme. | BACKGROUND
Glioblastoma multiforme (GBM) is an aggressive malignancy, but there is marked heterogeneity in survival time. Health care disparities have demonstrated significance in oncologic outcomes but have not been clearly examined in this patient population. We investigated the role of sociodemographic variables in ... | 10.4103/2152-7806.181985 | 27,217,966 | Surgical neurology international | 2,016 | ||
Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells. | Both macrophages (MAC) and dendritic cells (DC) are members of the mononuclear phagocyte system (MPS) with monocytes (MO) as common precursor cells. Cells of the MPS are able to take up, process and present antigens to T lymphocytes, thereby inducing a primary or secondary immune response. Adhesion molecules are of cru... | 10.1046/j.1365-2567.2000.00056.x | 10,929,059 | D018821:CD18 Antigens; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D003713:Dendritic Cells; D015870:Gene Expression; D006801:Humans; D039201:Integrin alpha3beta1; D019012:Integrin beta1; D016023:Integrins; D008070:Lipopolysaccharides; D008264:Macrophages; D009000:Monocytes; D012333:RNA, Messenger; D0... | Immunology | 2,000 | D018821:CD18 Antigens; D039201:Integrin alpha3beta1; D019012:Integrin beta1; D016023:Integrins; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha |
Predictors of long-term survival free from relapses after extraction of infected CIED. | Aims
We explored the possible predictors of long-term prognosis after transvenous lead extraction (TLE) for a cardiac implantable device related infection (CIEDI), including the modified Duke score result.
Methods and results
We performed a single centre prospective observational study in a population of consecutive ... | 10.1093/europace/eux121 | 29,016,771 | D000368:Aged; D017147:Defibrillators, Implantable; D020878:Device Removal; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016... | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology | 2,018 | |
Organization of amniocentesis for antenatal genetic diagnosis. | In spite of the rapid development of amniocentesis for genetic diagnosis, it is still only a small fraction of the mothers at risk who are having the procedure performed. The medical and public health problems associated with genetic amniocentesis are discussed on the basis of the experience gathered in a major medical... | 10.3109/00016347809154192 | 622,893 | D000328:Adult; D000649:Amniocentesis; D000757:Anencephaly; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D000013:Congenital Abnormalities; D005260:Female; D006801:Humans; D008423:Maternal Age; D008661:Metabolism, Inborn Errors; D011247:Pregnancy; D012732:Sex Determination Analysis; D016136:Spina Bifida ... | Acta obstetricia et gynecologica Scandinavica | 1,978 | |
Time-Resolved Intermediate-Volatility and Semivolatile Organic Compound Emissions from Household Coal Combustion in Northern China. | Coal combustion in low-efficiency household stoves results in the emission of large amounts of nonmethane organic compounds (NMOCs), including intermediate-volatility compounds (IVOCs) and semivolatile organic compounds (SVOCs). This conceptual picture is reasonably well established, however, quantitative assessment of... | 10.1021/acs.est.9b00734 | 31,288,521 | D000393:Air Pollutants; D002681:China; D003031:Coal; D009930:Organic Chemicals; D014835:Volatilization | Environmental science & technology | 2,019 | D000393:Air Pollutants; D003031:Coal; D009930:Organic Chemicals |
SOX2 activation predicts prognosis in patients with head and neck squamous cell carcinoma. | SOX2 copy number and mRNA expression were analysed to examine the clinical significance of SOX2 activation in HNSCC. Gene expression signatures reflecting SOX2 activation were identified in an HNSCC cohort. Patients with HNSCC were classified into two subgroups according to the gene expression signature: SOX2-high and ... | 10.1038/s41598-018-20086-w | 29,374,236 | D000368:Aged; D002294:Carcinoma, Squamous Cell; D005260:Female; D018628:Gene Dosage; D020869:Gene Expression Profiling; D006258:Head and Neck Neoplasms; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger; D055748:SOXB1 Transcription Factors; D016019:Survival Analysis; D016896:T... | Scientific reports | 2,018 | D012333:RNA, Messenger; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors |
Endobronchial therapy of neoplasms. | The techniques and modalities provided by interventional pulmonology play a major role in the management of patients with symptomatic airways obstruction. The majority of these obstructions are part of pulmonary involvement by primary lung neoplasms or metastatic lesions from other organs. Benign lesions, although capa... | 10.1016/s1052-3359(02)00041-8 | 12,698,642 | D000402:Airway Obstruction; D001918:Brachytherapy; D001984:Bronchial Neoplasms; D001999:Bronchoscopy; D017679:Cryotherapy; D004106:Dilatation; D006801:Humans; D006979:Hyperthermia, Induced; D017075:Laser Coagulation; D010778:Photochemotherapy; D015607:Stents | Chest surgery clinics of North America | 2,003 | |
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. | The trisubstituted acridine derivative BRACO-19 has been designed to interact with and stabilize the quadruplex DNA structures that can be formed by folding of the single-stranded repeats at the 3' end of human telomeres. We suggest that the BRACO-19 complex inhibits the catalytic function of telomerase in human cancer... | 15,486,186 | D016475:3T3 Cells; D000166:Acridines; D000818:Animals; D015153:Blotting, Western; D002384:Catalysis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016922:Cellular Senescence; D002875:Chromosomes; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004247:DNA; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands... | Molecular cancer therapeutics | 2,004 | D000166:Acridines; D019941:Cyclin-Dependent Kinase Inhibitor p16; D008024:Ligands; D012235:Rhodamines; C022027:lissamine rhodamine B; D004247:DNA; D019098:Telomerase; C454064:BRACO-19 | |
Sharpness overconstancy: the roles of visibility and current context. | In a previous study we found that blurred edges presented in peripheral vision look sharper than when they are looked at directly, a phenomenon we have called peripheral sharpness overconstancy (Galvin et al. (1997). Vision Research, 37, 2035-2039). In the current study we show that when visibility of the stimulus edge... | 10.1016/s0042-6989(98)00306-x | 10,492,827 | D000328:Adult; D015350:Contrast Sensitivity; D005556:Form Perception; D005584:Fovea Centralis; D006801:Humans; D010364:Pattern Recognition, Visual; D011594:Psychometrics; D012684:Sensory Thresholds; D013997:Time Factors; D014794:Visual Fields | Vision research | 1,999 | |
Preloads generated with repeated tightening in three types of screws used in dental implant assemblies. | PURPOSE
Abutment screw loosening, especially in the case of cemented single tooth restorations, is a cause of implant restoration failure. This study compared three screws (titanium alloy, gold alloy, and gold-coated) with similar geometry by recording the preload induced when torques of 10, 20, and 35 Ncm were used fo... | 10.1111/j.1532-849X.2006.00096.x | 16,681,498 | D000704:Analysis of Variance; D001863:Bone Screws; D000044:Dental Abutments; D003722:Dental Alloys; D003758:Dental Implantation, Endosseous; D019250:Dental Implants, Single-Tooth; D003764:Dental Materials; D019232:Dental Restoration Failure; D003793:Dental Restoration, Permanent; D003799:Dental Stress Analysis; D006047... | Journal of prosthodontics : official journal of the American College of Prosthodontists | 2,006 | D003722:Dental Alloys; D003764:Dental Materials; D006047:Gold Alloys; D014025:Titanium |
Anterotracheal temperature during and after exercise in the guinea pig. | We measured the temperature in the anterotracheal region of the guinea pig during and after various intensities of exercise (from 20 to 100 m/3 min). The temperature decreased during exercise, and the maximal drop of the temperature increased with increasing intensity of exercise up to a speed of 80 m/3 min. When the e... | 10.1159/000196063 | 1,485,008 | D000818:Animals; D001250:Asthma, Exercise-Induced; D001831:Body Temperature; D004195:Disease Models, Animal; D006168:Guinea Pigs; D005082:Physical Exertion; D014132:Trachea | Respiration; international review of thoracic diseases | 1,992 | |
Aberrant amygdala functional connectivity at rest in pediatric anxiety disorders. | BACKGROUND
Childhood onset of anxiety disorders is associated with greater functional impairment and burden across the lifespan. Recent work suggests that generalized anxiety disorder (GAD) is characterized by dysfunctional connectivity in amygdala-based circuits at rest in adolescents, consistent with adults. However,... | 10.1186/s13587-014-0015-4 | 25,530,842 | Biology of mood & anxiety disorders | 2,014 | ||
Isolation and molecular characterization of Toxoplasma gondii in a colony of captive black-capped squirrel monkeys (Saimiri boliviensis). | Toxoplasmosis is commonly asymptomatic; however, it can be a fatal multisystemic disease in some animal species, such as New World monkeys. An outbreak of acute fatal toxoplasmosis was reported in a colony of black-capped squirrel monkeys (Saimiri boliviensis) from the zoo of La Plata, Argentina. Post-mortem examinatio... | 26,299,363 | D000818:Animals; D000836:Animals, Zoo; D001118:Argentina; D016054:DNA, Protozoan; D004196:Disease Outbreaks; D005838:Genotype; D008297:Male; D051379:Mice; D008992:Monkey Diseases; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012453:Saimiri; D014122:Toxoplasma; D014124:Toxoplasm... | Parasitology international | 2,015 | D016054:DNA, Protozoan | |
Chubby face and the biochemical parameters for the early diagnosis of neonatal intrahepatic cholestasis caused by citrin deficiency. | OBJECTIVES
To identify facial and biochemical characteristics as early clinical features of neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).
PATIENTS AND METHODS
Ten patients with diagnoses of NICCD by SLC25A13 mutation analysis in Taiwan were recruited. A "Chubby Index" was developed for objective... | 10.1097/MPG.0b013e318162d96d | 18,664,871 | D044466:Asian People; D001663:Bilirubin; D001774:Blood Chemical Analysis; D002135:Calcium-Binding Proteins; D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic; D003937:Diagnosis, Differential; D005145:Face; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008111:Liver Function Test... | Journal of pediatric gastroenterology and nutrition | 2,008 | D002135:Calcium-Binding Proteins; D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins; D027361:Organic Anion Transporters; C119629:SLC25A13 protein, human; D000509:alpha-Fetoproteins; C008822:citrin; D001663:Bilirubin |
Lunar transportation scenarios utilising the Space Elevator. | The Space Elevator (SE) concept has begun to receive an increasing amount of attention within the space community over the past couple of years and is no longer widely dismissed as pure science fiction. In light of the renewed interest in a, possibly sustained, human presence on the Moon and the fact that transportatio... | 10.1016/j.actaastro.2005.03.016 | 16,010,760 | D018534:Earth, Planet; D004607:Elevators and Escalators; D005160:Facility Design and Construction; D006801:Humans; D008962:Models, Theoretical; D016081:Moon; D013026:Space Flight; D018531:Spacecraft; D014186:Transportation | Acta astronautica | 2,005 | |
Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages. | Cerebral malaria is responsible for a large proportion of the estimated one million deaths caused by Plasmodium falciparum malaria annually. This disease is associated with excessive pro-inflammatory cytokine production resulting from dysregulated host responses to infection. On the basis of reports indicating potent a... | 10.4269/ajtmh.2009.09-0204 | 19,815,878 | D000818:Animals; D000962:Antimalarials; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006801:Humans; D015850:Interleukin-6; D017737:Macrophages, Peritoneal; D016779:Malaria, Cerebral; D051379:Mice; D008810:Mice, Inbred C57BL; D018512:Parasitemia; D010962:Plasmodium berghei; D019821:Simvastatin; D051195:... | The American journal of tropical medicine and hygiene | 2,009 | D000962:Antimalarials; D015850:Interleukin-6; C493486:Tlr2 protein, mouse; C493487:Tlr4 protein, mouse; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D019821:Simvastatin |
Protons and Ca2+: ionic allies in tumor progression? | Ion channels and G-protein-coupled receptors (GPCRs) play a fundamental role in cancer progression by influencing Ca(2+) influx and signaling pathways in transformed cells. Transformed cells thrive in a hostile environment that is characterized by extracellular acidosis that promotes the pathological phenotype. The pat... | 10.1152/physiol.00005.2011 | 21,841,073 | D000818:Animals; D002118:Calcium; D020013:Calcium Signaling; D018450:Disease Progression; D006801:Humans; D006859:Hydrogen; D007473:Ion Channels; D009369:Neoplasms; D011522:Protons; D043562:Receptors, G-Protein-Coupled | Physiology (Bethesda, Md.) | 2,011 | D007473:Ion Channels; D011522:Protons; D043562:Receptors, G-Protein-Coupled; D006859:Hydrogen; D002118:Calcium |
Factors controlling peat chemistry and vegetation composition in Sudbury peatlands after 30 years of pollution emission reductions. | The objective of this research was to assess factors controlling peat and plant chemistry, and vegetation composition in 18 peatlands surrounding Sudbury after more than 30 years of large (>95%) pollution emission reductions. Sites closer to the main Copper Cliff smelter had more humified peat and the surface horizons ... | 26,160,672 | D044822:Biodiversity; D003300:Copper; D004784:Environmental Monitoring; D004787:Environmental Pollution; D029791:Ericaceae; D008669:Metallurgy; D009532:Nickel; D012987:Soil; D012989:Soil Pollutants; D044003:Sphagnopsida | Environmental pollution (Barking, Essex : 1987) | 2,015 | D012987:Soil; D012989:Soil Pollutants; D003300:Copper; D009532:Nickel | |
Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles. | Energy dispersive X-ray spectroscopy within the scanning transmission electron microscope (STEM) provides accurate elemental analysis with high spatial resolution, and is even capable of providing atomically resolved elemental maps. In this technique, a highly focused electron beam is incident upon a thin sample and th... | 10.3791/52815 | 27,403,838 | D021621:Imaging, Three-Dimensional; D053758:Nanoparticles; D013052:Spectrometry, X-Ray Emission; D014054:Tomography | Journal of visualized experiments : JoVE | 2,016 | |
Evolution of diversity in spatially structured Escherichia coli populations. | The stochastic Ricker population model was used to investigate the generation and maintenance of genetic diversity in a bacterial population grown in a spatially structured environment. In particular, we showed that Escherichia coli undergoes dramatic genetic diversification when grown as a biofilm. Using a novel biofi... | 10.1128/AEM.00063-09 | 19,648,364 | D018441:Biofilms; D004269:DNA, Bacterial; D004926:Escherichia coli; D019143:Evolution, Molecular; D014644:Genetic Variation; D015233:Models, Statistical | Applied and environmental microbiology | 2,009 | D004269:DNA, Bacterial |
Prenatal Alcohol Exposure Leads to Enhanced Serine 9 Phosphorylation of Glycogen Synthase Kinase-3β (GSK-3β) in the Hippocampal Dentate Gyrus of Adult Mouse. | BACKGROUND
The goal of this study was to evaluate the expression and serine 9 phosphorylation of glycogen synthase kinase (GSK-3β) within the adult hippocampal dentate gyrus (DG) in a preclinical mouse model of fetal alcohol spectrum disorders. GSK-3β is a multifunctional kinase that modulates many hippocampal processe... | 10.1111/acer.13489 | 28,865,114 | D000428:Alcohol Drinking; D000818:Animals; D018891:Dentate Gyrus; D000431:Ethanol; D005260:Female; D000071679:Glycogen Synthase Kinase 3 beta; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010766:Phosphorylation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012694:... | Alcoholism, clinical and experimental research | 2,017 | D000431:Ethanol; D012694:Serine; D000071679:Glycogen Synthase Kinase 3 beta |
Posterior interosseous nerve entrapment due to bilobed parosteal lipoma. | Entrapment of posterior interosseous nerve (PIN) can be due to fracture dislocation of elbow, fibrous arcade of Frohse, neoplasms (lipoma, schwannoma), ganglion cysts and rheumatoid synovitis. Parosteal lipomas are extremely rare. These tumors grow slowly and as they grow, they can compress a nearby nerve producing sen... | 10.1016/j.jcot.2019.10.006 | 31,992,941 | Journal of clinical orthopaedics and trauma | 2,020 | ||
Effects of inhibitory compounds in lignocellulosic hydrolysates on Mortierella isabellina growth and carbon utilization. | Oleaginous fungus Mortierella isabellina showed excellent lipid conversion on non-detoxified lignocellulosic hydrolysate. This study investigated the effects of inhibitory compounds (furfural, hydroxymethylfurfural, and ferulic and coumaric acids) in lignocellulosic hydrolysate on M. isabellina growth and lipid product... | 25,710,679 | D000596:Amino Acids; D002244:Carbon; D002247:Carbon Isotopes; D003373:Coumaric Acids; D005227:Fatty Acids; D005285:Fermentation; D005662:Furaldehyde; D006868:Hydrolysis; D007553:Isotope Labeling; D007700:Kinetics; D008031:Lignin; D050356:Lipid Metabolism; D020094:Mortierella | Bioresource technology | 2,015 | D000596:Amino Acids; D002247:Carbon Isotopes; D003373:Coumaric Acids; D005227:Fatty Acids; C036909:lignocellulose; C008046:5-hydroxymethylfurfural; D002244:Carbon; D008031:Lignin; C004999:ferulic acid; D005662:Furaldehyde | |
Prevalence, Safety and Long-Term Retention Rates of Biologics in Hong Kong from 2001 to 2015. | BACKGROUND
Biologic agents were initially introduced as treatment for rheumatoid arthritis (RA) but have since been used for other medical conditions. As new biologics become increasingly widespread in treatment regimens, it is important to understand their safety and utilization in the post-marketing context.
PURPOS... | 10.1007/s40264-019-00844-z | 31,168,709 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018501:Antirheumatic Agents; D001688:Biological Products; D002648:Child; D016208:Databases, Factual; D005260:Female; D006723:Hong Kong; D006801:Humans; D007239:Infections; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D010818:Pract... | Drug safety | 2,019 | D018501:Antirheumatic Agents; D001688:Biological Products; D000069285:Infliximab |
Emergency department (ED) utilization and outcome of oldest old men presenting with geriatric syndromes in a veterans care home in Taiwan. | The first presentation of elderly people in the emergency department (ED) is commonly nonspecific and atypical, often in the form of geriatric syndromes, i.e. falls, immobility, incontinence, or deteriorating mental function. The purpose of this study was to evaluate the management and outcomes of institutionalized eld... | 10.1016/S0167-4943(09)70010-X | 20,005,424 | D000368:Aged; D000369:Aged, 80 and over; D004632:Emergency Medical Services; D005853:Geriatrics; D006299:Health Services for the Aged; D006707:Homes for the Aged; D006764:Hospitals, Community; D006801:Humans; D008297:Male; D009735:Nursing Homes; D012189:Retrospective Studies; D013577:Syndrome; D013624:Taiwan; D016896:T... | Archives of gerontology and geriatrics | 2,009 | |
Typical and atypical PET/CT findings in non-cancerous conditions. | Nuclear Medicine multimodality imaging, such as positron emission tomography/computed tomography PET/CT, refers to metabolic tissue characteristics integrated with anatomical details. Fluorine-18-fluorodeoxyglucose (18F-FDG) is the most diffuse radiopharmaceutical and its application is spreading beyond the area of onc... | 10.1967/s002449912005 | 32,222,731 | D004194:Disease; D006801:Humans; D000072078:Positron Emission Tomography Computed Tomography | Hellenic journal of nuclear medicine | 2,020 | |
Etoricoxib Induced Toxic Epidermal Necrolysis in a case of Systemic Lupus Erythematosus: A Case Report. | Toxic epidermal necrolysis is a potentially life-threatening dermatological condition whose pathogenesis and exact treatment are not yet known. Drugs like anticonvulsants, allopurinol and non-steroidal anti-inflammatory drugs like etoricoxib, a selective cyclo-oxygenase-2 inhibitor prescribed for pain management are as... | 10.31729/jnma.7665 | 36,705,131 | D000328:Adult; D005260:Female; D006801:Humans; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000077613:Etoricoxib; D005076:Exanthema; D008180:Lupus Erythematosus, Systemic; D013262:Stevens-Johnson Syndrome | JNMA; journal of the Nepal Medical Association | 2,022 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D000077613:Etoricoxib |
Paper-Based Analytical Devices for the Rapid and Direct Electrochemical Detection of Hydrogen Peroxide in Tomato Leaves Inoculated with Botrytis cinerea. | Hydrogen peroxide (H2O2) is an important signaling molecule and plays key roles in multiple plant physiological processes. The rapid and direct monitoring of H2O2 could improve our understanding of its regulatory mechanisms in plants. In this study, we developed a paper-based analytical device consisting of a disposabl... | 10.3390/s20195512 | 32,993,080 | D020171:Botrytis; D006861:Hydrogen Peroxide; D018551:Solanum lycopersicum; D010935:Plant Diseases; D018515:Plant Leaves | Sensors (Basel, Switzerland) | 2,020 | D006861:Hydrogen Peroxide |
TNF-α Priming Elicits Robust Immunomodulatory Potential of Human Tonsil-Derived Mesenchymal Stem Cells to Alleviate Murine Colitis. | Mesenchymal stem cells (MSCs) have been spotlighted in the field of cell therapies as a promising tool for the treatment of intractable inflammatory diseases. However, their therapeutic potency still shows a gap between preclinical and clinical settings, and distinctive characteristics of specific tissue-derived MSCs a... | 10.3390/biomedicines8120561 | 33,276,479 | Biomedicines | 2,020 | ||
Use of noninvasive procedures in the cardiovascular risk assessment of hypertensive and normotensive individuals. | BACKGROUND
Arterial hypertension is associated with a high prevalence of vascular alterations. The use of noninvasive procedures to assess peripheral arterial diseases in the ranking of cardiovascular risks has been increasingly valued in clinical practice and should be adopted in nursing.
OBJECTIVE
To identify the c... | 26,897,348 | D000328:Adult; D055109:Ankle Brachial Index; D001794:Blood Pressure; D001795:Blood Pressure Determination; D002318:Cardiovascular Diseases; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors | Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing | 2,016 | ||
Droplet-based microtumor model to assess cell-ECM interactions and drug resistance of gastric cancer cells. | Gastric cancer (GC) is a common aggressive malignant tumor with high incidence and mortality worldwide. GC is classified into intestinal and diffuse types according to the histo-morphological features. Because of distinctly different clinico-pathological features, new cancer therapy strategies and in vitro preclinical ... | 10.1038/srep41541 | 28,128,310 | D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D058750:Epithelial-Mesenchymal Transition; D005109:Extracellular Matrix; D005455:Fluorescent Antibody Technique; D006801:Humans; D046210:Microfluidic Analytical Techniques; D015398:Signal Transduction; D013274:Stomach Neoplasm... | Scientific reports | 2,017 | D051176:beta Catenin |
Antecedents of teenage pregnancy from a 14-year follow-up study using data linkage. | BACKGROUND
Many western nations continue to have high rates of teenage pregnancies and births, which can result in adverse outcomes for both mother and child. This study identified possible antecedents of teenage pregnancy using linked data from administrative sources to create a 14-year follow-up from a cross-sectiona... | 10.1186/1471-2458-10-63 | 20,149,221 | D000028:Abortion, Induced; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003625:Data Collection; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D011247:Pregnancy; D011253:Pregnancy in Adolescence; D012307:Ri... | BMC public health | 2,010 | |
The optimization and validation of the Biotyper MALDI-TOF MS database for the identification of Gram-positive anaerobic cocci. | Gram-positive anaerobic cocci (GPAC) account for 24%-31% of the anaerobic bacteria isolated from human clinical specimens. At present, GPAC are under-represented in the Biotyper MALDI-TOF MS database. Profiles of new species have yet to be added. We present the optimization of the matrix-assisted laser desorption-ioniz... | 10.1016/j.cmi.2016.06.016 | 27,404,365 | D001421:Bacteria, Anaerobic; D015373:Bacterial Typing Techniques; D016208:Databases, Factual; D006094:Gram-Positive Bacteria; D006801:Humans; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S; D015203:Reproducibility of Results; D017422:Sequence Analysis, DNA; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-I... | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases | 2,016 | D012336:RNA, Ribosomal, 16S |
Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat. | High dietary fructose causes insulin resistance syndrome (IRS), primarily due to simultaneous induction of genes involved in glucose, lipid and mitochondrial oxidative metabolism. The present study evaluates effect of a hepatoprotective agent, silymarin (SYM) on fructose-induced metabolic abnormalities in the rat and a... | 24,486,395 | D000284:Administration, Oral; D000818:Animals; D015415:Biomarkers; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D004334:Drug Administration Schedule; D004730:Endothelium, Vascular; D005632:Fructose; D005786:Gene Expression Regulation; D007333:Insulin Resistance; D05... | European journal of pharmacology | 2,014 | D015415:Biomarkers; D012838:Silymarin; D005632:Fructose | |
Into the future: patient-centredness endures in longitudinal integrated clerkship graduates. | OBJECTIVES
This study was intended to determine if previously identified educational benefits of the Harvard Medical School (HMS) Cambridge Integrated Clerkship (CIC) endure over time.
METHODS
The authors' earlier work compared the 27 graduates in the first three cohorts of students undertaking the CIC with a compari... | 10.1111/medu.12413 | 24,713,035 | D001291:Attitude of Health Personnel; D002321:Career Choice; D002982:Clinical Clerkship; D003479:Curriculum; D003625:Data Collection; D004501:Education, Medical; D005500:Follow-Up Studies; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D017145:Models, Educational; D010817:Physician-Patient Relations; D0... | Medical education | 2,014 | |
Chief Nursing Officer Perspectives on Nursing Theory-Guided Practice. | OBJECTIVE
The purpose of this study was to identify what guides nursing practice.
BACKGROUND
Change occurred when the Magnet Recognition Program® no longer required a nursing theory.
METHODS
This was a mixed-methods study to identify the process used to implement nursing theory-guided practice and the relationship ... | 10.1097/NNA.0000000000001062 | 34,690,303 | D006801:Humans; D007407:Interviews as Topic; D009718:Nurse Administrators; D009742:Nursing Theory; D017410:Practice Guidelines as Topic; D024382:Professional Role; D036301:Qualitative Research; D011795:Surveys and Questionnaires | The Journal of nursing administration | 2,021 | |
Three peptides from the ANF prohormone NH(2)-terminus are natriuretic and/or kaliuretic. | The present investigation was designed to determine whether peptides derived from the NH(2)-terminal portion of the 126-amino acid prohormone (pro) of atrial natriuretic factor (ANF) have natriuretic and diuretic properties similar to ANF. Three peptides consisting of amino acids 1-30 [(proANF-(1-30)], 31-67 [proANF-(3... | 10.1152/ajprenal.1990.258.5.F1401 | 2,140,017 | D000818:Animals; D009320:Atrial Natriuretic Factor; D055598:Chemical Phenomena; D002621:Chemistry; D004231:Diuresis; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D008297:Male; D009318:Natriuresis; D010455:Peptides; D011188:Potassium; D011498:Protein Precursors; D051381:Rats; D011919:Rats, Inbred Strains; D... | The American journal of physiology | 1,990 | D010455:Peptides; D011498:Protein Precursors; D009320:Atrial Natriuretic Factor; D011188:Potassium |
DXA-Derived Visceral Adipose Tissue (VAT) in Elderly: Percentiles of Reference for Gender and Association with Metabolic Outcomes. | This study aimed to establish the Dual-Energy X-ray Absorptiometry (DXA)-derived Visceral adipose tissue (VAT) reference values for gender and assess the metabolic outcomes associated to the VAT in a cohort of elderly patients. The sample included 795 elderly patients (226/569: men/women) aged 65-100 years (mean age 80... | 10.3390/life10090163 | 32,846,931 | Life (Basel, Switzerland) | 2,020 | ||
Analysis of skin disposition and metabolism of ethyl nicotinate after topical application using dual agar gel disc-inserted rats. | The skin disposition and metabolism of topically applied ethyl nicotinate (EN) were evaluated in dual agar gel disc-inserted hairless rats, which have two agar gel discs subcutaneously inserted into the abdominal region as drug receptors, and a topical formulation containing EN placed on either side of the gel disc thr... | 10.1248/bpb.31.85 | 18,175,947 | D000279:Administration, Cutaneous; D000362:Agar; D000818:Animals; D008297:Male; D009539:Nicotinic Acids; D010539:Permeability; D051381:Rats; D054772:Rats, Hairless; D012867:Skin; D012869:Skin Absorption | Biological & pharmaceutical bulletin | 2,008 | D009539:Nicotinic Acids; D000362:Agar; C037328:ethylnicotinate |
Rhesus monkey (Macaca mulatta) complex learning skills reassessed. | Results from three experiments on basic learning and transfer in rhesus monkeys (Macaca mulatta) are reported in which fully automated testing paradigms, afforded by the Language Research Center's Computerized Test System (LRC-CTS), were employed. Performance levels for discrimination learning set, transfer index, and... | 10.1007/BF02547618 | 11,539,108 | D000818:Animals; D001331:Automation; D003626:Data Display; D004193:Discrimination Learning; D007858:Learning; D008253:Macaca mulatta; D008297:Male; D011581:Psychological Tests; D011587:Psychology, Comparative; D012984:Software; D013647:Task Performance and Analysis; D014163:Transfer, Psychology; D014584:User-Computer I... | International journal of primatology | 1,991 | |
Microtensile bond strengths for six 2-step and two 1-step self-etch adhesive systems to enamel and dentin. | PURPOSE
To examine the microtensile bond strengths (microTBS) of six 1-step and one 2-step self-etch systems to dentin and ground enamel.
METHODS
Resin composite buildups were bonded to buccal and lingual ground enamel surfaces, and to occlusal dentin of third molars using the following 1-step adhesives: Xeno IV (XE)... | 23,724,549 | D000134:Acid Etching, Dental; D000268:Adhesiveness; D003188:Composite Resins; D001840:Dental Bonding; D003738:Dental Cements; D003743:Dental Enamel; D003764:Dental Materials; D003799:Dental Stress Analysis; D003804:Dentin; D017220:Dentin-Bonding Agents; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates; ... | American journal of dentistry | 2,013 | C074864:All-Bond system; C505694:Clearfil S3 Bond; C438313:Clearfil SE Bond; D003188:Composite Resins; D003738:Dental Cements; D003764:Dental Materials; D017220:Dentin-Bonding Agents; C498353:G-Bond; C532472:Go self-etching primer; D008689:Methacrylates; C408584:Prompt L-Pop; D019279:Resin Cements; C487957:Xeno III; D0... | |
Elbow extension in the C5 quadriplegic using functional neuromuscular stimulation. | A system has been designed to provide overhead reach in C5/6 quadriplegic subjects using functional neuromuscular stimulation (FNS) for control of the triceps muscle. The system uses the position of the arm in space as the input command, relieving the user from having to supply a conscious command signal. By measuring ... | 10.1109/10.32110 | 2,787,285 | D004551:Elbow Joint; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D006801:Humans; D009068:Movement; D011782:Quadriplegia | IEEE transactions on bio-medical engineering | 1,989 | |
Inhibition of type-1 plasminogen activator inhibitor production by antisense oligonucleotides in human vascular endothelial and smooth muscle cells. | We have hypothesized that type-1 plasminogen activator inhibitor (PAI-1) may exacerbate accumulation of extracellular matrix in atheroma by inhibiting local generation of plasmin and intramural proteolysis. Thus, suppression of PAI-1 expression would decrease atherogenesis. To inhibit expression of PAI-1 in cultured hu... | 8,188,696 | D001483:Base Sequence; D002478:Cells, Cultured; D004730:Endothelium, Vascular; D005341:Fibrinolysin; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D009131:Muscle, Smooth, Vascular; D016376:Oligonucleotides, Antisense; D017395:Plasminogen Activator Inhibitor 1; D012333:RNA, Messenger | The Journal of biological chemistry | 1,994 | D016376:Oligonucleotides, Antisense; D017395:Plasminogen Activator Inhibitor 1; D012333:RNA, Messenger; D005341:Fibrinolysin | |
New and interesting Peritelini of the Western Mediterranean fauna. XX. A novel Meira (Jacquelin du Val, 1852) species from the Ligurian Alps. | Meira diottii, nov.sp. from the Ligurian Alps is described. Relevant anatomical characters are detailed and illustrated with drawings and photography. Characteristic sensilla on the penis are identified and illustrated with scanning electron microscopy. Relationships with other Meira species are proposed. | 10.11646/zootaxa.3716.4.8 | 26,106,795 | D000818:Animals; D001517:Coleoptera; D003710:Demography; D007558:Italy; D019083:Mediterranean Region; D013045:Species Specificity | Zootaxa | 2,013 | |
Population pharmacokinetics and exposure-response analyses of teduglutide in adult and pediatric patients with short bowel syndrome. | Teduglutide is a recombinant analog of human glucagon-like peptide-2 that regulates the functional and structural integrity of the cells lining the gastrointestinal tract. Teduglutide is approved for the treatment of patients with short bowel syndrome (SBS) who are dependent on parenteral support (PS). Population pharm... | 10.1111/cts.13117 | 34,402,197 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005765:Gastrointestinal Agents; D006801:Humans; D007223:Infant; D007564:Japan; D008875:Middle Aged; D010288:Parenteral Nutrition; D010455:Peptides; D012778:Short Bowel Syndrome; D055815:Young Adult | Clinical and translational science | 2,021 | D005765:Gastrointestinal Agents; D010455:Peptides; C494910:teduglutide |
Sex differences in the correlation of emotional control and amygdala volumes in adolescents. | We examined male and female adolescents (8-18 years of age) that were scanned with structural brain MRI and looked for a correlation between volume of the right or the left amygdala and parent-reported ability of emotional control. A sex difference was found in the correlation between emotional control and the correcte... | 10.1097/WNR.0b013e32833e7866 | 20,729,768 | D000293:Adolescent; D000375:Aging; D000679:Amygdala; D002648:Child; D004644:Emotions; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D012727:Sex Characteristics; D012919:Social Behavior | Neuroreport | 2,010 | |
Innervation of cutaneous structures in the mouse hind paw: a confocal microscopy immunohistochemical study. | The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-relate... | 10.1002/jnr.490410113 | 7,545,760 | D000818:Animals; D015415:Biomarkers; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D005528:Foot; D007150:Immunohistochemistry; D008465:Mechanoreceptors; D051379:Mice; D018613:Microscopy, Confocal; D009419:Nerve Tissue Proteins; D012867:Skin; D013373:Substance P; D013869:Thiolester Hydrolases; D043222:Ubiquit... | Journal of neuroscience research | 1,995 | D015415:Biomarkers; D009419:Nerve Tissue Proteins; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D015740:Calcitonin Gene-Related Peptide |
Policy, Systems, and Environmental Change Strategies in the Supplemental Nutrition Assistance Program-Education (SNAP-Ed). | OBJECTIVE
To categorize and quantify how states planned to use policy, systems, and environmental (PSE) change strategies in the Supplemental Nutrition Assistance Program-Education (SNAP-Ed).
METHODS
Qualitative content analysis of SNAP-Ed annual plans from all 50 states, District of Columbia, Guam, and the US Virgin... | 10.1016/j.jneb.2021.09.008 | 35,027,308 | D004522:Educational Status; D063105:Food Assistance; D006266:Health Education; D006801:Humans; D018673:Nutrition Policy; D009752:Nutritional Status; D057766:Policy | Journal of nutrition education and behavior | 2,022 | |
[A case of retroperitoneal Castleman's disease associated with bladder tumor and a review of 59 cases in Japan]. | We present a case of retroperitoneal Castleman's disease associated with bladder tumor. The patient was a 62-year-old man, who underwent partial cystectomy under a diagnosis of bladder tumor in 1989. Subsequently, recurrent bladder tumor was detected and he consulted the outpatient clinic at our University Hospital in ... | 1,414,756 | D005871:Castleman Disease; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008297:Male; D008875:Middle Aged; D012187:Retroperitoneal Space; D001749:Urinary Bladder Neoplasms | Hinyokika kiyo. Acta urologica Japonica | 1,992 | ||
Adenoid cystic carcinoma of the salivary glands: an immunohistochemical analysis. | Adenoid cystic carcinoma is a specific variant of adenocarcinoma with a characteristic cribriform appearance. The tumor may arise from salivary glands and various other sites, but the origin and cellular composition of this unique neoplasm have been controversial. A potential use of immunohistochemistry is to provide a... | 10.1016/0030-4220(88)90116-8 | 2,451,197 | D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen; D003528:Carcinoma, Adenoid Cystic; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007633:Keratins; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins; D012468:Salivary Gland Neoplasms; D012469:Salivary ... | Oral surgery, oral medicine, and oral pathology | 1,988 | D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D007633:Keratins |
[Not Available]. | Virosomal hepatitis A vaccine contains formalin-inactivated hepatitis A (strain RG-SB) antigen adsorbed on to immunopotentiating reconstituted influenza virosomes (IRIVs). IRIVs act as an adjuvant and may stimulate both the cell-mediated and humoral immune responses to vaccine antigens. In noncomparative studies, viros... | 10.2165/00063030-199707030-00006 | 18,031,096 | BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy | 1,997 | ||
Measuring on-line compliance in ventilated infants using hot wire anemometry. | We investigated the validity of using tidal volume (VT) as measured by the neonatal volume monitor (NVM) to derive respiratory compliance. The NVM is a noninvasive device that measures VT by hot wire anemometry. The quotient of VT and the inflation pressure amplitude from the mechanical ventilator provided a measure of... | 10.1097/00003246-199010000-00004 | 2,145,132 | D000403:Airway Resistance; D006801:Humans; D007231:Infant, Newborn; D008170:Lung Compliance; D008991:Monitoring, Physiologic; D015203:Reproducibility of Results; D012121:Respiration, Artificial; D012212:Rheology; D013696:Temperature; D013990:Tidal Volume | Critical care medicine | 1,990 | |
Lyophilized Polyvinylpyrrolidone Hydrogel for Culture of Human Oral Mucosa Stem Cells. | This work shows the synthesis of a polyvinylpyrrolidone (PVP) hydrogel by heat-activated polymerization and explores the production of hydrogels with an open porous network by lyophilisation to allow the three-dimensional culture of human oral mucosa stem cells (hOMSCs). The swollen hydrogel showed a storage modulus si... | 10.3390/ma14010227 | 33,466,418 | Materials (Basel, Switzerland) | 2,021 | ||
Speech onset enhancement improves intelligibility in adverse listening conditions for cochlear implant users. | Speech perception by cochlear implant (CI) users can be very good in quiet but their speech intelligibility (SI) performance decreases in noisy environments. Because recent studies have shown that transient parts of the speech envelope are most important for SI in normal-hearing (NH) listeners, the enhanced envelope (E... | 10.1016/j.heares.2016.09.002 | 27,697,583 | D000328:Adult; D000368:Aged; D000465:Algorithms; D001307:Auditory Perception; D003054:Cochlear Implants; D005260:Female; D006801:Humans; D008144:Loudness Perception; D008297:Male; D008875:Middle Aged; D009622:Noise; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D013065:Speech Intelligibil... | Hearing research | 2,016 | |
Primary Bone Lymphoma in Axial Skeleton in a Middle-Aged Female Presented as Recurrent Anemia. | Primary bone lymphoma (PBL) is a peculiar extranodal presentation of non-Hodgkin's lymphoma. Primary bone diffuse large B-cell lymphoma (DLBCL) is the most common pathological type, comprising about 80% of PBL. The diagnosis of PBL depends on the combined clinical examination and imaging studies and is confirmed with i... | 10.1159/000506362 | 32,308,590 | Case reports in oncology | 2,020 | ||
Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis. | The histone acetyltransferase (HAT) p300/CBP has been shown to undergo autoacetylation on lysines in an apparent regulatory loop that stimulates HAT activity. Here we have developed a strategy to introduce acetyl-Lys at up to six known modification sites in p300/CBP HAT using a combination of circular permutation and e... | 10.1021/ja909466d | 20,063,892 | D000105:Acetyl Coenzyme A; D000107:Acetylation; D000595:Amino Acid Sequence; D008958:Models, Molecular; D008969:Molecular Sequence Data; D050880:p300-CBP Transcription Factors | Journal of the American Chemical Society | 2,010 | D000105:Acetyl Coenzyme A; D050880:p300-CBP Transcription Factors; C100367:p300-CBP-associated factor |
Predicting EGFR mutation status in lung adenocarcinoma: development and validation of a computed tomography-based radiomics signature. | Patients with epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma can benefit from targeted therapy. However, noninvasively determination of EGFR mutation status before targeted therapy remains a challenge. This study constructed a nomogram based on a combination of radiomics features with the clin... | 33,575,086 | American journal of cancer research | 2,021 | |||
Q & A. | Gregory A. Petsko is Gyula and Katica Tauber Professor of Biochemistry and Chemistry and Director of the Rosenstiel Basic Medical Sciences Research Center at Brandeis University. He did his undergraduate work at Princeton and his graduate work as a Rhodes Scholar at Oxford University. He held faculty positions at Wayne... | 10.1016/j.cub.2003.09.043 | 14,561,414 | D008967:Molecular Biology; D012106:Research | Current biology : CB | 2,003 | |
Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer. | The role of estrogen signaling in regulating prostate tumorigenesis is relatively underexplored. Although, an increasing body of evidence has linked estrogen receptor beta (ERß) to prostate cancer, the function of estrogen receptor alpha (ERα) in prostate cancer is not very well studied. We have discovered a novel role... | 10.18632/oncotarget.6317 | 26,575,018 | D000818:Animals; D001859:Bone Neoplasms; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D018920:Coculture Techniques; D058750:Epithelial-Mesenchymal Transition; D004965:Estrogen Antagonists; D047628:Estrogen Receptor alpha; D004967:Estrogens; D015972:Gene Expression Regul... | Oncotarget | 2,015 | C506487:ESR1 protein, human; D004965:Estrogen Antagonists; D047628:Estrogen Receptor alpha; D004967:Estrogens |
Evidence for thyroid hormone-dependent and independent glucocorticoid actions in cultured cells. Studies on the induction of growth hormone and glutamine synthetase in GH1 cells and tyrosine aminotransferase in Reuber H-35 cells. | The induction of growth hormone synthesis and mRNA by thyroid hormone in cultured GH1 cells is mediated by the thyroid hormone nuclear receptor. In addition, the regulation of the growth hormone response by glucocorticoid is highly dependent on the action of thyroid hormone. To clarify whether thyroid hormone has a gen... | 28,320 | D002460:Cell Line; D003907:Dexamethasone; D004790:Enzyme Induction; D005974:Glutamate-Ammonia Ligase; D013006:Growth Hormone; D007700:Kinetics; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D014284:Triiodothyronine; D014444:Tyrosine Transaminase | The Journal of biological chemistry | 1,978 | D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D014284:Triiodothyronine; D003907:Dexamethasone; D013006:Growth Hormone; D014444:Tyrosine Transaminase; D005974:Glutamate-Ammonia Ligase | |
Next-generation association studies for complex traits. | A new study successfully applies complementary whole-genome sequencing and imputation approaches to establish robust disease associations in an isolated population. This strategy is poised to help elucidate the role of variants at the low end of the allele frequency spectrum in the genetic architecture of complex trait... | 10.1038/ng0411-287 | 21,445,070 | D000483:Alleles; D024722:Cardiac Myosins; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D018995:Myosin Heavy Chains; D020641:Polymorphism, Single Nucleotide; D012804:Sick Sinus Syndrome | Nature genetics | 2,011 | C094239:MYH6 protein, human; D024722:Cardiac Myosins; D018995:Myosin Heavy Chains |
Engendering persistent organic room temperature phosphorescence by trace ingredient incorporation. | Pure organic persistent room temperature phosphorescence (RTP) has shown great potential in information encryption, optoelectronic devices, and bio-applications. However, trace impurities are generated in synthesis, causing unpredictable effects on the luminescence properties. Here, an impurity is isolated from a pure ... | 10.1126/sciadv.abf9668 | 33,962,952 | Science advances | 2,021 | ||
Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells. | PF1, an anti-inflammatory drug candidate, was nephrotoxic in cynomolgus monkeys in a manner that was qualitatively comparable to that observed with the two previous exploratory drug candidates (PF2and PF3). Based on the severity of nephrotoxicity, PF1 ranked between the other two compounds, withPF2 inducing mortality a... | 10.1016/j.tox.2009.01.006 | 19,378,467 | D000818:Animals; D000893:Anti-Inflammatory Agents; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D015507:Drugs, Investigational; D006801:Humans; D007687:Kidney Tubules, Proximal; D008252:Macaca fascicularis; D027362:Organic Anion Transport Protein 1; D029362:Organic Anion Transporters, Sodium-Independe... | Toxicology | 2,009 | D000893:Anti-Inflammatory Agents; D015507:Drugs, Investigational; D027362:Organic Anion Transport Protein 1; D029362:Organic Anion Transporters, Sodium-Independent; C114338:organic anion transport protein 3 |
Solid Swallow Examination During High Resolution Manometry and EGJ-Distensibility Help Identify Esophageal Outflow Obstruction in Non-obstructive Dysphagia. | Single water swallow (SWS) high-resolution manometry (HRM) may miss relevant esophageal motility disorders. Solid test meal (STM) during HRM and lately the functional lumen imaging probe (FLIP) have been shown to be of diagnostic value in the assessment of motility disorders. We aimed to assess the diagnostic yield of ... | 10.1007/s00455-021-10260-0 | 33,609,164 | D003680:Deglutition Disorders; D015154:Esophageal Motility Disorders; D004940:Esophageal Stenosis; D004943:Esophagogastric Junction; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged | Dysphagia | 2,022 | |
Duodenal hematoma after upper endoscopy and biopsy in a 4-year-old girl. | We describe a 4-year-old girl who developed a duodenal hematoma after upper endoscopy and biopsy. Although rare, duodenal hematoma formation can occur after upper endoscopy and biopsy in otherwise healthy children. A young child presenting with a duodenal hematoma in the absence of a clear mechanism of either previous ... | 10.1097/01.pec.0000235840.52072.0c | 16,983,252 | D001706:Biopsy; D002675:Child, Preschool; D004378:Duodenal Diseases; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006406:Hematoma; D006801:Humans | Pediatric emergency care | 2,006 | |
Differential expression of the 67 kDa laminin receptor in cancer. | During tumor invasion and metastasis, cancer cells interact with host tissues. Penetration of the extracellular matrix by cancer cells is mediated in part by interaction of cell surface receptors with laminin, the major glycoprotein component of the basement membrane. A variety of cell surface laminin binding proteins ... | 8,257,781 | D000818:Animals; D001665:Binding Sites; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D007797:Laminin; D009369:Neoplasms; D012333:RNA, Messenger; D017474:Receptors, Laminin | Seminars in cancer biology | 1,993 | D018076:DNA, Complementary; D007797:Laminin; D012333:RNA, Messenger; D017474:Receptors, Laminin | |
Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway. | Background: Patients with metastatic radioiodine-refractory papillary thyroid carcinoma (PTC) have limited treatment options and a poor prognosis. There is an urgent need to develop new drugs targeting PTC for clinical application. Apatinib, a novel small-molecule tyrosine kinase inhibitor (TKI), is highly selective fo... | 10.3389/fonc.2020.00217 | 32,219,060 | Frontiers in oncology | 2,020 | ||
Perceived Importance of the Benefits and Harms of Colorectal Cancer Screening: A Best-Worst Scaling Study. | OBJECTIVES
To elicit the relative importance of the benefits and harms of colorectal cancer (CRC) screening among potential screening participants in the Dutch population.
METHODS
In a consensus meeting with 11 experts, risk reduction of CRC and CRC deaths (benefits) and complications from colonoscopy, stress of rece... | 10.1016/j.jval.2022.12.015 | 36,646,279 | D008297:Male; D000328:Adult; D006801:Humans; D005260:Female; D055088:Early Detection of Cancer; D015179:Colorectal Neoplasms; D003113:Colonoscopy; D010342:Patient Acceptance of Health Care; D009780:Occult Blood; D008403:Mass Screening | Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research | 2,023 | |
Immunohistochemical demonstration of alpha1-antichymotrypsin and alpha1 -antitrypsin in the normal pituitary gland and its tumors. | The immunohistochemical distribution of the protease inhibitors alpha1-antichymotrypsin (alpha1-ACT) and alpha1-antitrypsin (alpha1-AT) has been documented in the normal human pituitary gland and in a series of pituitary tumors. In normal gland, alpha1-ACT was localized mainly in the dendritic folliculostellate cells, ... | 10.1007/BF02915626 | 32,357,605 | Endocrine pathology | 1,990 | ||
Site-specific conjugation and labelling of prostate antibody 7E11C5.3 (CYT-351) with technetium-99m. | Attachment of chelating agents to the sugar residues of antibodies for subsequent radiolabelling is an attractive approach since it may have less effect on the immunoreactivity than attachment through lysine residues, which are distributed throughout the antibody and may be present near the antigen binding site. We hav... | 10.1007/BF00841403 | 9,169,572 | D000818:Animals; D000911:Antibodies, Monoclonal; D006801:Humans; D007553:Isotope Labeling; D008297:Male; D051379:Mice; D011471:Prostatic Neoplasms; D016719:Radioimmunodetection; D013667:Technetium | European journal of nuclear medicine | 1,997 | D000911:Antibodies, Monoclonal; C101173:CYT-351 monoclonal antibody; D013667:Technetium |
The Accuracy of a Low-Cost GPS System during Football-Specific Movements. | An affordable player monitoring solution could make the evaluation of external loading more accessible across multiple levels of football (soccer). The present study aimed to determine the accuracy of a newly designed and low-cost Global Positioning System (GPS) whilst performing match-specific movement patterns. Sixte... | 10.52082/jssm.2021.126 | 33,707,995 | D000054:Acceleration; D000068598:Data Accuracy; D003654:Deceleration; D040362:Geographic Information Systems; D006801:Humans; D007590:Jogging; D008297:Male; D009068:Movement; D015203:Reproducibility of Results; D012420:Running; D012916:Soccer; D000085944:Team Sports; D013996:Time and Motion Studies; D055815:Young Adult | Journal of sports science & medicine | 2,021 | |
Low fasting plasma insulin is associated atrial fibrillation in men from a cohort study--the Malmö preventive project. | BACKGROUND
Type 2 diabetes has been associated with increased incidence of atrial fibrillation (AF) and cardiovascular disease. Controversy remains regarding the role of insulin in the epidemiology of AF risk. The aim of the present study was to study the association between fasting plasma insulin (FPI) and incidence o... | 10.1186/1471-2261-14-107 | 25,150,967 | D000328:Adult; D001281:Atrial Fibrillation; D015415:Biomarkers; D001786:Blood Glucose; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007328:Insulin; D008297:Male; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors; D0... | BMC cardiovascular disorders | 2,014 | D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin |
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