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Comparison of model monomeric and polymeric alkyl stationary phases on silica using sum-frequency spectroscopy. | Model monomeric and polymeric stationary phases were examined using sum-frequency spectroscopy and contact angle measurements in order to determine structural differences between the two stationary phases. Octadecyldimethylchlorosiloxane (ODMS) monolayers and ODMS/methyl siloxane (MS) mixed monolayers in contact with w... | 10.1016/s0021-9673(02)01834-4 | 12,564,673 | D011108:Polymers; D012822:Silicon Dioxide; D013057:Spectrum Analysis | Journal of chromatography. A | 2,003 | D011108:Polymers; D012822:Silicon Dioxide |
Elevated pulmonary tuberculosis biomarker miR-423-5p plays critical role in the occurrence of active TB by inhibiting autophagosome-lysosome fusion. | Rapid diagnosis of pulmonary tuberculosis is an effective measure to prevent the spread of tuberculosis. However, the grim fact is that the new, rapid, and safe methods for clinical diagnosis are lacking. Moreover, although auto-lysosome is critical in clearing Mycobacterium tuberculosis, the pathological significance o... | 10.1080/22221751.2019.1590129 | 30,898,038 | D000328:Adult; D000368:Aged; D000071182:Autophagosomes; D015415:Biomarkers; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008247:Lysosomes; D008297:Male; D035683:MicroRNAs; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D060888:Real-Time Polymerase Chain Reaction; D017423:Sequence Analys... | Emerging microbes & infections | 2,019 | D015415:Biomarkers; C548900:MIRN423 microRNA, human; D035683:MicroRNAs; C424440:VPS33A protein, human; D033921:Vesicular Transport Proteins |
The Impact of Dementia on Cancer Treatment Decision-Making, Cancer Treatment, and Mortality: A Mixed Studies Review. | Dementia and cancer occur commonly in older adults. Yet, little is known about the effect of dementia on cancer treatment and outcomes in patients diagnosed with cancer, and no guidelines exist. We performed a mixed studies review to assess the current knowledge and gaps on the impact of dementia on cancer treatment de... | 10.1093/jncics/pkab002 | 34,056,540 | D000368:Aged; D001291:Attitude of Health Personnel; D017028:Caregivers; D000066491:Clinical Decision-Making; D003704:Dementia; D017051:Hospice Care; D006801:Humans; D008017:Life Expectancy; D009369:Neoplasms; D016017:Odds Ratio; D010166:Palliative Care; D016016:Proportional Hazards Models; D036301:Qualitative Research;... | JNCI cancer spectrum | 2,021 | |
Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients. | Crohn disease (CD) is a multifactorial autoimmune disease which is characterized by chronic and recurrent gastrointestinal tract inflammatory disorder. However, the molecular mechanisms of CD remain unclear. Increasing evidences have demonstrated that circular RNAs (circRNAs) participate in the pathogenesis of a variet... | 10.1097/MD.0000000000016072 | 31,261,517 | D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D003424:Crohn Disease; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged; D012313:RNA; D000079962:RNA, Circular; D012372:ROC Curve; D060888:Real-Time Polymerase Chain Reacti... | Medicine | 2,019 | D015415:Biomarkers; D000079962:RNA, Circular; D012313:RNA |
Systematic Raman Spectroscopic Study of the Isomorphy Between the Arsenate Minerals Roselite, Wendwilsonite, Zincroselite, Brandtite, and Rruffite. | In nature, numerous minerals are known with the general formula X2M(TO4)2·2(H2O) and an important group is formed by minerals with T = As. Most of these occur as minor or trace minerals in environments such as hydrothermal alterations of primary sulfides and arsenides. X-ray photoelectron spectroscopy and Raman spectro... | 10.1177/0003702820984254 | 33,319,605 | Applied spectroscopy | 2,021 | ||
Rituximab induces a flare-up of activated neutrophil extracellular traps under in vitro conditions. | Purpose: During neutrophil extracellular traps (NET) formation granulocytes release a decondensed chromatin web that is studded with antimicrobial proteins. These NET engulf and kill pathogens like bacteria and fungi. NET formation is part of the innate immune response but can also contribute to the aggravation of auto... | 10.1080/08923973.2022.2088386 | 35,695,816 | D006801:Humans; D065206:Extracellular Traps; D000069283:Rituximab | Immunopharmacology and immunotoxicology | 2,022 | D000069283:Rituximab |
Phenotypic knockouts of selected metabolic pathways by targeting enzymes with camel-derived nanobodies (V(HH)s). | Surveying the dynamics of metabolic networks of Gram-negative bacteria often requires the conditional shutdown of enzymatic activities once the corresponding proteins have been produced. We show that given biochemical functions can be entirely suppressed in vivo with camel antibodies (VHHs, nanobodies) that target acti... | 10.1016/j.ymben.2015.04.002 | 25,887,637 | D000818:Animals; D001426:Bacterial Proteins; D002162:Camelus; D049308:Dioxygenases; D004926:Escherichia coli; D016958:Pseudomonas putida; D061905:Single-Domain Antibodies | Metabolic engineering | 2,015 | D001426:Bacterial Proteins; D061905:Single-Domain Antibodies; D049308:Dioxygenases |
[Effects of moxibustion on acupoints at "opening" time on testicular tissue apoptosis in aging rats]. | OBJECTIVE
To observe the effect of "lingguibafa" moxibustion at "opening" time on the level of superoxide dismutase(SOD), malondialdehyde(MDA), the protein expressions of B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X protein (Bax) in aging model rats.
METHODS
SD rats were randomly divided into blank control, model... | 10.13702/j.1000-0607.20211280 | 36,734,502 | D008297:Male; D051381:Rats; D000818:Animals; D009071:Moxibustion; D017207:Rats, Sprague-Dawley; D051028:bcl-2-Associated X Protein; D015669:Acupuncture Points; D017209:Apoptosis; D000375:Aging; D013482:Superoxide Dismutase | Zhen ci yan jiu = Acupuncture research | 2,023 | D051028:bcl-2-Associated X Protein; D013482:Superoxide Dismutase |
Pulse oximetry and circulatory kinetics associated with pulse volume amplitude measured by photoelectric plethysmography. | Through a catheter placed in a superficial vein on the finger, we observed a pulsatile venous pressure. To delineate the relationship between the pulsatile venous pressure and the pulse volume amplitude (PVA) recorded by photoelectric plethysmography (PEPG), both tracings were simultaneously recorded. When the PVA chan... | 3,777,465 | D000328:Adult; D000368:Aged; D001775:Blood Circulation; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010991:Plethysmography; D011673:Pulsatile Flow; D012212:Rheology; D014690:Venous Pressure | Anesthesia and analgesia | 1,986 | ||
Identification of a novel frameshift mutation in the DMD gene as the cause of muscular dystrophy in a Norfolk terrier dog. | BACKGROUND
A Norfolk terrier was referred to the Animal Health Trust neurology department with suspected dystrophin-deficient muscular dystrophy (DD-MD), which was confirmed by clinical workup and immunohistochemistry.
FINDINGS
Exon resequencing of the canine Duchenne Muscular Dystrophy (DMD) gene was undertaken to s... | 10.1186/s40575-015-0019-4 | 26,401,335 | Canine genetics and epidemiology | 2,015 | ||
Virucidal effect of stimulated eosinophils on human immunodeficiency virus type 1. | Eosinophils, when stimulated, release a variety of agents that can be toxic to ingested or extracellular targets. Among these systems is one that consists of eosinophil peroxidase (EPO), H2O2, and a halide. We report here that phorbol myristate acetate (PMA)-stimulated human eosinophils are virucidal to HIV-1 in a chlo... | 10.1089/aid.1996.12.25 | 8,825,615 | D001965:Bromides; D002478:Cells, Cultured; D047209:Eosinophil Peroxidase; D004804:Eosinophils; D015497:HIV-1; D006801:Humans; D006861:Hydrogen Peroxide; D007454:Iodides; D010544:Peroxidases; D013755:Tetradecanoylphorbol Acetate | AIDS research and human retroviruses | 1,996 | D001965:Bromides; D007454:Iodides; D006861:Hydrogen Peroxide; D047209:Eosinophil Peroxidase; D010544:Peroxidases; D013755:Tetradecanoylphorbol Acetate |
Antigenic relationships within the genus Salmonella as revealed by anti-Salmonella enteritidis monoclonal antibodies. | A panel of 38 monoclonal antibodies (MAbs) that react with outer membrane proteins (OMPs) of Salmonella enteritidis was produced. On the basis of their binding pattern in ELISA, the MAbs were divided into three groups. The first group, consisting of 15 MAbs, was found to be Salmonella-specific as they did not cross-rea... | 10.1023/a:1015249520170 | 12,090,290 | D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000940:Antigenic Variation; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D051379:Mice; D008807:Mice, Inbred BALB C; D012475:Salmonella; D012480... | Veterinary research communications | 2,002 | D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins |
Effect of vitamin E supplementation on neutrophil function, milk composition and plasmin activity in dairy cows in a commercial herd. | Fifty-six Holstein dairy cows from a commercial dairy herd in the Northern part of Greece were used to determine the effect of vitamin E supplementation on immune parameters, milk composition and milk quality. Cows were assigned to one of two experimental groups: control (no vitamin E supplementation) and vitamin E sup... | 10.1017/s002202990400010x | 15,354,572 | D000818:Animals; D002417:Cattle; D002452:Cell Count; D019587:Dietary Supplements; D005260:Female; D005341:Fibrinolysin; D007785:Lactose; D008055:Lipids; D008892:Milk; D008894:Milk Proteins; D009504:Neutrophils; D010958:Plasminogen; D011247:Pregnancy; D013481:Superoxides; D013755:Tetradecanoylphorbol Acetate; D014568:Ur... | The Journal of dairy research | 2,004 | D008055:Lipids; D008894:Milk Proteins; D013481:Superoxides; D014810:Vitamin E; D010958:Plasminogen; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator; D007785:Lactose; D013755:Tetradecanoylphorbol Acetate |
Positive intravenous line tip cultures as predictors of bacteraemia. | Intravenous line tip cultures provide valuable information when taken in conjunction with blood culture, but in practice are often performed in isolation. This retrospective study has evaluated: (1) the frequency of isolated line tip culture; and (2) whether the species of microorganism isolated from line tip culture, ... | 10.1016/s0195-6701(98)90022-6 | 9,777,519 | D016470:Bacteremia; D002408:Catheters, Indwelling; D003428:Cross Infection; D006801:Humans; D007262:Infusions, Intravenous; D013203:Staphylococcal Infections | The Journal of hospital infection | 1,998 | |
Paper spray portable mass spectrometry for screening of phorbol ester contamination in glycerol-based medical products. | The Jatropha curcas plant (Jatropha) has been proposed as a source of biodiesel fuel, as it yields crude glycerol as an abundant by-product. Its by-products could serve as a starting material in making glycerol for FDA-regulated products. Jatropha is not regarded as a source of edible vegetable oil since it contains ph... | 10.1007/s00216-019-01717-1 | 30,888,469 | D000818:Animals; D001672:Biocompatible Materials; D004340:Drug Contamination; D005290:Ferric Compounds; D035264:Flowers; D005456:Fluorescent Dyes; D005990:Glycerol; D006801:Humans; D031286:Jatropha; D057230:Limit of Detection; D013058:Mass Spectrometry; D046529:Microscopy, Electron, Transmission; D010209:Paper; D010703... | Analytical and bioanalytical chemistry | 2,019 | D001672:Biocompatible Materials; D005290:Ferric Compounds; D005456:Fluorescent Dyes; D010703:Phorbol Esters; D005990:Glycerol |
Automatic 3D modelling of human diaphragm from lung MDCT images. | PURPOSE
The thoracic diaphragm separates the thorax and abdomen cavity and also performs an important function in respiration. An automatic algorithm to model the human full diaphragm from multi-detector computed tomography (MDCT) images has been developed and tested.
METHOD
The modelling algorithm comprises these st... | 10.1007/s11548-015-1298-7 | 26,429,786 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D066186:Costal Cartilage; D003964:Diaphragm; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008168:Lung; D008297:Male; D008875:Middle Aged; D008953:Models, A... | International journal of computer assisted radiology and surgery | 2,016 | |
Insulin- and contraction-induced glucose transporter 4 traffic in muscle: insights from a novel imaging approach. | Insulin- and contraction-mediated glucose transporter 4 (GLUT4) trafficking have different kinetics in mature skeletal muscle. Intravital imaging indicates that insulin-stimulated GLUT4 trafficking differs between t-tubules and sarcolemma. In contrast, contraction-induced GLUT4 trafficking does not differ between membr... | 10.1097/JES.0b013e318275574c | 23,072,821 | D000818:Animals; D003952:Diagnostic Imaging; D051275:Glucose Transporter Type 4; D006801:Humans; D007328:Insulin; D007700:Kinetics; D009119:Muscle Contraction; D018482:Muscle, Skeletal; D012508:Sarcolemma | Exercise and sport sciences reviews | 2,013 | D051275:Glucose Transporter Type 4; D007328:Insulin |
Influence of the river flow pulse on the maturity, resilience, and sustainability of tropical coastal ecosystems. | Coastal marine ecosystems have structural and functional features usually connected by the seasonal transfer of nutrients and organisms. These environments can utilize inter-ecosystem subsidies to increase resilience and maturity and support human activities like fishing. However, the importance of the connection and t... | 10.1016/j.marenvres.2022.105806 | 36,459,755 | D006801:Humans; D017753:Ecosystem; D045483:Rivers; D018533:Biomass; D063366:Estuaries; D012621:Seasons | Marine environmental research | 2,023 | |
Increased Body Mass Index Correlates with Less Favorable Postoperative Outcomes After Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea: A Retrospective Cohort Study. | OBJECTIVE
Obstructive sleep apnea is associated with high morbidity. Hypoglossal nerve stimulation (HNS) has become a novel (neuro-) surgical treatment strategy for obstructive sleep apnea, demonstrating good success rates. Beyond predefined inclusion and exclusion criteria, no precise data are available, enabling indi... | 10.1016/j.wneu.2023.09.027 | 37,714,455 | World neurosurgery | 2,023 | ||
Neoadjuvant famitinib and camrelizumab, a new combined therapy allowing surgical resection of the primary site for anaplastic thyroid carcinoma. | BACKGROUND
Anaplastic thyroid cancer (ATC) is considered the most lethal thyroid cancer, with an overall 5-year survival rate below 10%. The FDA approved a BRAF/MEK inhibitor combination for the treatment of patients with BRAF-mutated ATC. However, effective therapeutic options for patients with wild-type BRAF are lack... | 10.1002/cnr2.1770 | 36,535,914 | D006801:Humans; D065646:Thyroid Carcinoma, Anaplastic; D020360:Neoadjuvant Therapy; D048493:Proto-Oncogene Proteins B-raf; D013964:Thyroid Neoplasms; D047428:Protein Kinase Inhibitors | Cancer reports (Hoboken, N.J.) | 2,023 | C000631724:camrelizumab; C584390:famitinib; D048493:Proto-Oncogene Proteins B-raf; D047428:Protein Kinase Inhibitors |
Subgingival irrigation with amine fluoride-stannous fluoride gel in treated periodontal pockets. | PURPOSE
To evaluate the long-term effect of subgingival irrigations with amine fluoride mixed with stannous fluoride on the repopulation of bacteria in deep periodontal pockets (> 5 mm) following the active phase of non-surgical mechanical treatment.
MATERIALS AND METHODS
A split-mouth design was utilized in eight pe... | 7,986,443 | D000588:Amines; D001421:Bacteria, Anaerobic; D001439:Bacteroides; D015169:Colony Count, Microbial; D005881:Gingiva; D006801:Humans; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010514:Periodontal Pocket; D010518:Periodontitis; D012008:Recurrence; D018709:Statistics, Nonparametric; D007507:Therapeutic Irrigation... | American journal of dentistry | 1,994 | D000588:Amines; D014002:Tin Fluorides; C075174:amine fluoride gel | |
Neoadjuvant Endocrine Therapy Versus Neoadjuvant Chemotherapy in Node-Positive Invasive Lobular Carcinoma. | BACKGROUND
Neoadjuvant chemotherapy (NACT) is often recommended for patients with node-positive invasive lobular carcinoma (ILC) despite unclear benefit in this largely hormone receptor-positive (HR+) group. We sought to compare overall survival (OS) between patients with node-positive ILC who received neoadjuvant endo... | 10.1245/s10434-019-07564-9 | 31,342,392 | D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D047072:Aromatase Inhibitors; D001943:Breast Neoplasms; D018275:Carcinoma, Lobular; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009... | Annals of surgical oncology | 2,019 | D047072:Aromatase Inhibitors |
Not Just Checklists and Rainbows: Exploring Canadian Dietitians' Beliefs, Values, and Knowledge of Transgender Nutritional Care. | Purpose
Many transgender (short form: trans) people are experiencing disparities within Canadian health care systems, including nutritional and dietetic health care systems. This research explores the views, beliefs, and experiences of Canadian dietitians about trans nutritional care and seeks to understand how dietiti... | 10.1089/trgh.2021.0107 | 37,525,835 | Transgender health | 2,023 | ||
Diffusion abnormalities in temporal lobes of children with temporal lobe epilepsy: a preliminary diffusional kurtosis imaging study and comparison with diffusion tensor imaging. | In this preliminary study, we aimed to investigate the abnormalities of water diffusion in children with temporal lobe epilepsy (TLE). Eight children with unilateral TLE (according to electroencephalography, EEG) and eight age- and sex-matched controls were recruited. Diffusion tensor imaging (DTI)/diffusional kurtosis... | 10.1002/nbm.2809 | 22,674,871 | D016022:Case-Control Studies; D002648:Child; D004058:Diffusion; D056324:Diffusion Tensor Imaging; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe; D005260:Female; D006801:Humans; D008297:Male; D013702:Temporal Lobe | NMR in biomedicine | 2,012 | |
Treatment of patients with early and advanced Parkinson's disease with rotigotine transdermal system: age-relationship to safety and tolerability. | Although dopamine agonists (DAs) are sometimes perceived as poorly tolerated by the elderly, there is little clinical evidence to support these concerns. Safety and tolerability of rotigotine have been demonstrated in four 6-month randomized placebo-controlled studies: two in early Parkinson's disease (PD) and two in a... | 22,954,721 | D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease; D013764:Tetrahydronaphthalenes; D013876... | Parkinsonism & related disorders | 2,013 | D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; C047508:rotigotine | |
Study of human red cell NADH diaphorase (Dia1) in the Italian population. | A total of about 4,500 individuals from Northern, Central and Southern Italy have been analyzed for red cell NADH diaphorase. The results show that the Italians differ significantly (p less than 0.005) from the other examined populations of European origin by showing a higher frequency of the Dia2 allele (6.4%) and a l... | 10.1159/000153506 | 3,838,291 | D000328:Adult; D000483:Alleles; D002648:Child; D042966:Cytochrome-B(5) Reductase; D008058:Dihydrolipoamide Dehydrogenase; D004912:Erythrocytes; D005787:Gene Frequency; D006801:Humans; D007231:Infant, Newborn; D007558:Italy | Human heredity | 1,985 | D042966:Cytochrome-B(5) Reductase; D008058:Dihydrolipoamide Dehydrogenase |
Vascular myelopathies-vascular malformations of the spinal cord: presentation and endovascular surgical management. | Spinal cord vascular malformations are often a cause of spinal myelopathy. Endovascular surgical approaches to spinal cord vascular malformations have become an important adjunct and often the primary treatment of these disorders. Spinal cord vascular malformations may be divided into several categories based on their ... | 10.1055/s-2002-36535 | 12,524,557 | D000328:Adult; D000792:Angiography; D001164:Arteriovenous Fistula; D001165:Arteriovenous Malformations; D020785:Central Nervous System Vascular Malformations; D004621:Embolization, Therapeutic; D005260:Female; D006391:Hemangioma; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D01... | Seminars in neurology | 2,002 | |
Sequential Latent Structure Analysis of Segregated System Material in the Doll Play of Maltreated Children. | A range of assessment methodologies pertaining to attachment in children have been developed and validated during the past decades. The present study examined the validity of a sequential, profile-centered approach to the assessment of attachment disorganization using a doll play methodology developed by George and Sol... | 10.1007/s40653-017-0171-y | 32,318,159 | Journal of child & adolescent trauma | 2,018 | ||
Clinical significance of presenting syndromes on outcome after coronary artery bypass grafting. | OBJECTIVES
Evidence of an association between postoperative survival and the presenting syndrome following coronary artery bypass grafting (CABG) is limited. Our goal was to evaluate whether the presenting symptoms of acute coronary syndrome (ACS) or stable ischaemic heart disease were associated with mid-term survival... | 10.1093/icvts/ivz259 | 31,713,612 | D000368:Aged; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013577:Syndrome; D013997:Time Factors; D016896:Treatment Outcome;... | Interactive cardiovascular and thoracic surgery | 2,020 | |
Nanocages displaying SIRP gamma clusters combined with prophagocytic stimulus of phagocytes potentiate anti-tumor immunity. | Antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), play a crucial role in bridging innate and adaptive immunity; thereby, innate immune checkpoint blockade-based therapy is an attractive approach for the induction of sustainable tumor-specific immunity. The interaction between the cluster... | 10.1038/s41417-021-00372-y | 34,349,240 | D000818:Animals; D000943:Antigens, Differentiation; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005293:Ferritins; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008546:Melanoma, Experimental; D051379:Mice; D008810:Mice, Inbred C57BL; D049329:Nanostructures; D009360:Neoplastic Cells, Circulating; D... | Cancer gene therapy | 2,021 | D000943:Antigens, Differentiation; D011971:Receptors, Immunologic; C490691:SIRPG protein, human; D005293:Ferritins; C454461:FTH1 protein, human; D010088:Oxidoreductases |
The Broadly Tuned Odorant Receptor OR1A1 is Highly Selective for 3-Methyl-2,4-nonanedione, a Key Food Odorant in Aged Wines, Tea, and Other Foods. | Key food odorants are the most relevant determinants by which we detect, recognize, and hedonically evaluate the aroma of foods and beverages. Odorants are detected by our chemical sense of olfaction, comprising a set of approximately 400 different odorant receptor types. However, the specific receptor activity pattern... | 10.1093/chemse/bjw117 | 27,916,747 | D000473:Alkanes; D002478:Cells, Cultured; D003931:Diacetyl; D057809:HEK293 Cells; D006801:Humans; D009812:Odorants; D018035:Receptors, Odorant; D013662:Tea; D014920:Wine | Chemical senses | 2,017 | D000473:Alkanes; C525018:OR1A1 protein, human; D018035:Receptors, Odorant; D013662:Tea; C475572:3-methyl-2,4-nonanedione; D003931:Diacetyl |
From Routine to Research Laboratory: Strategies for the Diagnosis of Congenital Fibrinogen Disorders. | Congenital fibrinogen disorders (CFDs) encompass a heterogeneous group of fibrinogen defects with a wide spectrum of biological and clinical features. An accurate diagnosis is thus essential to assure the optimal management for the patient. Diagnosis involves a multistep approach starting with routine coagulation assay... | 10.1055/a-1182-3510 | 32,645,726 | D000347:Afibrinogenemia; D001780:Blood Coagulation Tests; D006801:Humans; D007753:Laboratories | Hamostaseologie | 2,020 | |
Seven-Tesla MRI of Hippocampal Sclerosis: An In Vivo Feasibility Study With Histological Correlations. | INTRODUCTION
Temporal lobe epilepsy (TLE) is the most frequent form of focal epilepsy in adults. Because approximately half of these patients develop drug resistance, epilepsy surgery designed to remove the epileptogenic zone is an excellent option in selected patients. Histopathological analyses of hippocampal specime... | 10.1097/RLI.0000000000000388 | 28,538,339 | D000328:Adult; D004833:Epilepsy, Temporal Lobe; D005240:Feasibility Studies; D005260:Female; D006624:Hippocampus; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012598:Sclerosis; D012680:Sensitivity and Specificity; D055815:Young Adult | Investigative radiology | 2,017 | |
Red Blood Cell Exchange in a Patient With Extramedullary Hematopoiesis and Cor Pulmonale Secondary to Beta Thalassemia. | RATIONALE
Beta thalassemia is a congenital defect in the production of the beta globin chain. Patients with beta thalassemia major will have higher levels of hemoglobin F (HbF), which is suboptimal in releasing oxygen to tissue. Herein, we describe the use of red blood cell (RBC) exchange transfusion, a therapy typical... | 10.7759/cureus.13638 | 33,824,791 | Cureus | 2,021 | ||
Maternal mental health mediates the effect of prenatal stress on infant temperament: The Harvey Mom Study. | Prenatal maternal stress and mental health problems are known to increase risk for developmental psychopathology in offspring, yet pathways leading to risk or resiliency are poorly understood. In a quasi-experimental design, we prospectively examined associations between disaster-related prenatal stress, maternal menta... | 10.1017/S0954579423000160 | 37,078,447 | Development and psychopathology | 2,023 | ||
Preclinical Assessment of Inflammatory Pain. | While acute inflammation is a natural physiological response to tissue injury or infection, chronic inflammation is maladaptive and engenders a considerable amount of adverse pain. The chemical mediators responsible for tissue inflammation act on nociceptive nerve endings to lower neuronal excitation threshold and sens... | 10.1111/cns.12486 | 26,663,896 | D000818:Animals; D004195:Disease Models, Animal; D005620:Freund's Adjuvant; D006801:Humans; D007249:Inflammation; D010146:Pain; D010147:Pain Measurement | CNS neuroscience & therapeutics | 2,016 | D005620:Freund's Adjuvant |
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. | Serine/threonine kinase Akt is a downstream effector protein of phosphatidylinositol-3-kinase (PI-3K). Many integrins can function as positive modulators of the PI-3K/Akt pathway. Integrin alpha 2 beta 1 is a collagen receptor that has been shown to induce specific signals distinct from those activated by other integri... | 10.1128/MCB.22.5.1352-1359.2002 | 11,839,802 | D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002448:Cell Adhesion; D002478:Cells, Cultured; D003094:Collagen; D004789:Enzyme Activation; D038362:Glycogen Synthase Kinase 3; D038341:Glycogen Synthase Kinases; D006801:Humans; D016023:Integrins; D020928:Mitogen-Activated Protein Kinases; D010749:Phosphoprotein P... | Molecular and cellular biology | 2,002 | D016023:Integrins; D011518:Proto-Oncogene Proteins; D038981:Receptors, Collagen; D003094:Collagen; D038341:Glycogen Synthase Kinases; C494918:AKT1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D020928:Mitogen-Activa... |
Characterizing the Collagen Network Structure and Pressure-Induced Strains of the Human Lamina Cribrosa. | Purpose
The purpose of this study was to measure the 2D collagen network structure of the human lamina cribrosa (LC), analyze for the correlations with age, region, and LC size, as well as the correlations with pressure-induced strains.
Methods
The posterior scleral cups of 10 enucleated human eyes with no known ocul... | 10.1167/iovs.18-25863 | 31,157,833 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D016880:Anisotropy; D001696:Biomechanical Phenomena; D055119:Elastic Modulus; D015353:Eye Enucleation; D005260:Female; D024022:Fibrillar Collagens; D006801:Humans; D021621:Imaging, Three-Dimensional; D007429:Intraocular Pressure; D008297:Male; D0088... | Investigative ophthalmology & visual science | 2,019 | D024022:Fibrillar Collagens |
[Model study of ozone microbial decontamination effectiveness of space station environment]. | Modeling experiments were performed to evaluate bactericide and fungicide effects of small ozone concentrations (0.3 mg/l of water and 47 mg/m3 of air) that can be generated onboard spacecraft following one hour after treatment. Over the period of treatment, reduction in aquatic microorganisms made up, depending on bio... | 9,661,780 | D001419:Bacteria; D015169:Colony Count, Microbial; D003666:Decontamination; D004866:Equipment Contamination; D005658:Fungi; D008954:Models, Biological; D010083:Oxidants, Photochemical; D010126:Ozone; D018531:Spacecraft; D014871:Water Microbiology | Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine | 1,998 | D010083:Oxidants, Photochemical; D010126:Ozone | |
Hormonal control of precopulatory sebaceous scent marking and ultrasonic mating vocalizations in male rats. | The effects of testosterone (T) and its major metabolites, estradiol (E2) and dihydrotestosterone (DHT), on the restoration of sebaceous scent marking and 50-kHz ultrasonic vocalizations in male rats were measured in two studies (Experiments 1 and 2) employing different hormone levels. Silastic capsule administration o... | 10.1016/0018-506x(91)90013-8 | 1,813,373 | D000818:Animals; D003307:Copulation; D013196:Dihydrotestosterone; D004958:Estradiol; D008297:Male; D009043:Motor Activity; D051381:Rats; D012627:Sebaceous Glands; D012724:Sex Attractants; D012726:Sexual Behavior, Animal; D012931:Social Environment; D013739:Testosterone; D014465:Ultrasonics; D014828:Vocalization, Animal | Hormones and behavior | 1,991 | D012724:Sex Attractants; D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol |
Characterization of Streptococcus pyogenes from Animal Clinical Specimens, Spain. | Streptococcus pyogenes appears to be almost exclusively restricted to humans, with few reports on isolation from animals. We provide a detailed characterization (emm typing, pulsed-field gel electrophoresis [PFGE], and multilocus sequence typing [MLST]) of 15 S. pyogenes isolates from animals associated with different ... | 10.3201/eid2312.151146 | 29,148,379 | D000818:Animals; D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D002999:Clone Cells; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D000072480:Farms; D015870:Gene Expression; D0... | Emerging infectious diseases | 2,017 | D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D018942:Macrolides; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; C551474:ermB protein, Streptococcus pyogenes; C014689:streptococcal M protein |
Prevalence and clinical significance of esophageal motility disorders in patients with laryngopharyngeal reflux symptoms. | BACKGROUND AND AIM
Esophageal motor dysfunction may underlie impaired bolus/refluxate clearance in laryngopharyngeal reflux (LPR). However, the prevalence of esophageal dysmotility and its correlation with reflux parameters and symptoms in LPR is not well established. The aim of this study was to evaluate the prevalenc... | 10.1111/jgh.15391 | 33,373,479 | D017097:Electric Impedance; D015154:Esophageal Motility Disorders; D050782:Esophageal pH Monitoring; D004942:Esophagitis, Peptic; D006801:Humans; D057045:Laryngopharyngeal Reflux; D008365:Manometry; D015995:Prevalence; D012189:Retrospective Studies | Journal of gastroenterology and hepatology | 2,021 | |
Potential biomarkers screening to predict side effects of dexamethasone in different cancers. | BACKGROUND
Excessive or prolonged usage of dexamethasone can cause serious side effects, but few studies reveal the related mechanism. Dexamethasone work differently in blood tumors and solid tumors, and the cause is still obscure. The aims of this study was to identify potential biomarkers associated with the side eff... | 10.1002/mgg3.1160 | 32,048,780 | D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D002478:Cells, Cultured; D003907:Dexamethasone; D006801:Humans; D008223:Lymphoma; D008297:Male; D053858:Metabolic Networks and Pathways; D011471:Prostatic Neoplasms; D060066:Protein Interaction Maps; D059467:Transcriptome; D014369:Tryptophan-tRNA Ligas... | Molecular genetics & genomic medicine | 2,020 | D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D003907:Dexamethasone; C517004:CDC25A protein, human; D020687:cdc25 Phosphatases; D014369:Tryptophan-tRNA Ligase; C073175:WARS1 protein, human |
Effect of high 131I doses on the bone uptake and retention of 90Sr and 90Y. | The uptake and retention of 90Sr and 90Y in mouse bones after injections of the two nuclides in equilibrium were examined after heavy thyroid irradiations from 131I deposited in the glands. The radiation doses to the thyroid glands as well as the gross doses to the femurs and humeri of the mice were calculated. The rad... | 10.3109/02841868609136415 | 3,030,053 | D000818:Animals; D001842:Bone and Bones; D005269:Femur; D006811:Humerus; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013326:Strontium Radioisotopes; D013961:Thyroid Gland; D013997:Time Factors; D015021:Yttrium Radioisotopes | Acta radiologica. Oncology | 1,986 | D007457:Iodine Radioisotopes; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes |
Paroxetine toxicity in a newborn after in utero exposure: clinical symptoms correlate with serum levels. | There are several case reports and case series that have examined the acute effects of selective serotonin reuptake inhibitors (SSRIs) on the newborn. There is considerable controversy whether the reported symptoms represent withdrawal from the SSRI or toxicity caused by the SSRI. A case of an infant who was exposed to... | 10.1097/01.ftd.0000187971.95000.25 | 16,418,684 | D000328:Adult; D001942:Breast Feeding; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009357:Neonatal Abstinence Syndrome; D017374:Paroxetine; D011247:Pregnancy; D017367:Selective Serotonin Reuptake Inhibitors | Therapeutic drug monitoring | 2,006 | D017367:Serotonin Uptake Inhibitors; D017374:Paroxetine |
The time course of attentional deployment in contextual cueing. | The time course of attention is a major characteristic on which different types of attention diverge. In addition to explicit goals and salient stimuli, spatial attention is influenced by past experience. In contextual cueing, behaviorally relevant stimuli are more quickly found when they appear in a spatial context th... | 10.3758/s13423-012-0338-3 | 23,138,628 | D000293:Adolescent; D000328:Adult; D001288:Attention; D003463:Cues; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D011930:Reaction Time; D013028:Space Perception; D013997:Time Factors; D014796:Visual Perception; D055815:Young Adult | Psychonomic bulletin & review | 2,013 | |
Experimental and theoretical approaches to the influence of the addition of pyrene to a series of Pd and Ni NHC-based complexes: catalytic consequences. | A series of Ni and Pd complexes with three different N-heterocyclic carbene (NHC)-based ligands (imidazolylidene, benzimidazolylidene and pyrene-imidazolylidene) has been prepared and fully characterized. The influence of the addition of pyrene to solutions containing these complexes is studied by means of NMR and UV/V... | 10.1002/chem.201404618 | 25,413,787 | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,015 | ||
Dominant male song performance reflects current immune state in a cooperatively breeding songbird. | Conspicuous displays are thought to have evolved as signals of individual "quality", though precisely what they encode remains a focus of debate. While high quality signals may be produced by high quality individuals due to "good genes" or favourable early-life conditions, whether current immune state also impacts sign... | 10.1002/ece3.1938 | 26,811,745 | Ecology and evolution | 2,016 | ||
Cytoprotective Agents to Avoid Chemotherapy Induced Sideeffects on Normal Cells: A Review. | Anticancer agents play a vital role in the cure of patients suffering from malignancy. Though, the chemotherapeutic agents are associated with various adverse effects which produce significant toxic symptoms in the patients. But this therapy affects both the malignant and normal cells and leads to constricted therapeut... | 10.2174/1568009619666190326120457 | 30,914,026 | D004999:Amifostine; D000970:Antineoplastic Agents; D019610:Cytoprotection; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D009369:Neoplasms; D020011:Protective Agents; D011837:Radiation-Protective Agents | Current cancer drug targets | 2,019 | D000970:Antineoplastic Agents; D020011:Protective Agents; D011837:Radiation-Protective Agents; D004999:Amifostine |
Synthesis and Characterization of the Nanogold-Bound Ternary Copper(II) Complex of Phenanthroline and Cysteine as Potential Anticancer Agents. | The aim of this study was to synthesize and characterize a nanogold-{[(Cu)(phen)(cys)(H2O)]NO3}n conjugate and to evaluate its antiproliferative property against the breast cancer cell line (MCF7) and normal cell line (MCF10A). Nanogold solution was prepared using the Turkevich method. In one approach, a ternary copper... | 10.1021/acsomega.2c01858 | 35,936,482 | ACS omega | 2,022 | ||
LncRNA TRHDE-AS1 and MiR-1275 as Promising Prognostic Biomarkers and Effects on Tumor Cell Progression in Gastric Cancer. | Gastric cancer is a common malignant tumor with a relatively poor prognosis after surgery. Non-coding RNA may serve as biomarkers for the progression and prognosis of various cancers. The clinical significance and biological function of lncRNA TRHDE-AS1 and miR-1275 in gastric cancer were assessed in this study. 119 pa... | 10.1620/tjem.2023.J009 | 36,792,178 | D006801:Humans; D013274:Stomach Neoplasms; D035683:MicroRNAs; D011379:Prognosis; D062085:RNA, Long Noncoding; D015415:Biomarkers; D049109:Cell Proliferation; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic; D002465:Cell Movement | The Tohoku journal of experimental medicine | 2,023 | D035683:MicroRNAs; D062085:RNA, Long Noncoding; D015415:Biomarkers; C000602308:MIRN1275 microRNA, human |
The isolation of newly formed bone associated cells in vitro: preliminary observations on origin and morphology. | Agar-medium suspensions were used to culture guinea-pig femoral bone fragments which had been physically depleted of marrow. A sequential study of the histological events occurring within the regenerating shaft, in the agar wholemount preparations and on the underlying coverglass allowed (1) the localization of the ear... | 624,334 | D000818:Animals; D001853:Bone Marrow; D001854:Bone Marrow Cells; D001861:Bone Regeneration; D001842:Bone and Bones; D002455:Cell Division; D002469:Cell Separation; D002478:Cells, Cultured; D006168:Guinea Pigs; D008297:Male | Experimental hematology | 1,978 | ||
Dorsal horn spatial representation of simple cutaneous stimuli. | A model of lamina III-IV dorsal horn cell receptive fields (RFs) has been developed to visualize the spatial patterns of cells activated by light touch stimuli. Low-threshold mechanoreceptive fields (RFs) of 551 dorsal horn neurons recorded in anesthetized cats were characterized by location of RF center in cylindrical... | 10.1152/jn.1998.79.2.983 | 9,463,457 | D000818:Animals; D002415:Cats; D004192:Discrimination, Psychological; D005260:Female; D008297:Male; D008959:Models, Neurological; D009473:Neuronal Plasticity; D009475:Neurons, Afferent; D009928:Organ Specificity; D017933:Peripheral Nervous System; D012867:Skin; D013116:Spinal Cord; D014110:Touch | Journal of neurophysiology | 1,998 | |
Noninvasive diagnosis of solitary pulmonary lesions in cancer patients based on 2-fluoro-2-deoxy-D-glucose avidity on positron emission tomography/computed tomography. | BACKGROUND
2-Fluoro-2-deoxy-D-glucose (FDG) imaging is highly accurate for assessing solitary pulmonary nodules (SPNs) in patients without known malignancy. In the current study, the authors evaluated FDG-positron emission tomography/computed tomography (PET/CT) for the characterization of SPN in cancer patients.
MET... | 10.1002/cncr.23928 | 18,924,145 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012680:Sensitivity and Specifici... | Cancer | 2,008 | D019788:Fluorodeoxyglucose F18 |
Quality of life, pulmonary function, and tomographic scan abnormalities after ARDS. | BACKGROUND
ARDS can produce a loss of lung function with persistent sequelae. This study aimed to evaluate health-related quality of life (HRQL) in survivors of ARDS compared with a healthy reference population and to determine the middle/long-term radiographic abnormalities and functional status, as well as their rela... | 10.1378/chest.10-2438 | 21,330,382 | D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016638:Critical Illness; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012128:Respiratory Distress Syndrome; D012129:Respiratory Function Tests; D013997:Time Facto... | Chest | 2,011 | |
The Effects of Particulate Matter on C57BL/6 Peritoneal and Alveolar Macrophages. | The presence of ambient particulate matter (PM) poses more dangers to human health than that of other common air pollutants such as Carbon dioxide (Co2) and ozone. Epidemiologic studies show a direct correlation between PM and the risk of respiratory and cardiovascular diseases. The immune system seems to play a criti... | 10.18502/ijaai.v19i6.4934 | 33,463,134 | D000393:Air Pollutants; D000818:Animals; D017209:Apoptosis; D001119:Arginase; D016207:Cytokines; D015870:Gene Expression; D007249:Inflammation; D016753:Interleukin-10; D016676:Macrophages, Alveolar; D017737:Macrophages, Peritoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D052247:Nitric Oxide Synthase Ty... | Iranian journal of allergy, asthma, and immunology | 2,020 | D000393:Air Pollutants; D016207:Cytokines; D052638:Particulate Matter; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D052247:Nitric Oxide Synthase Type II; D001119:Arginase |
Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality. | OBJECTIVE
This study evaluated the association between exposure to several chemicals and mortality from lymphohematopoietic cancer (LHC) among 16,579 synthetic rubber industry workers who were followed up from 1943 to 1998.
METHODS
Poisson regression analyses examined LHC rates in relation to butadiene, styrene, and ... | 10.1097/01.jom.0000172866.16615.db | 16,155,477 | D000328:Adult; D000368:Aged; D002617:Chemical Industry; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007938:Leukemia; D008223:Lymphoma; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D016273:Occupational Exposure; D012044:Regression Analysis; D012408:Rubber | Journal of occupational and environmental medicine | 2,005 | D012408:Rubber |
Direct true lumen cannulation for type A aortic dissection (Samurai technique) in emergency scenarios. | Choosing the optimal arterial cannulation site in type A aortic dissection may be challenging. Aortic dissection is a dynamic condition that can change at any time. Thus all the alternatives available should be known by surgeons in order to adapt to the possible problems that may arise. In this video tutorial, we prese... | 10.1510/mmcts.2021.073 | 34,787,967 | D000784:Aortic Dissection; D001366:Axillary Artery; D002315:Cardiopulmonary Bypass; D002404:Catheterization; D005263:Femoral Artery; D006801:Humans | Multimedia manual of cardiothoracic surgery : MMCTS | 2,021 | |
Hot-carrier photocurrent effects at graphene-metal interfaces. | Photoexcitation of graphene leads to an interesting sequence of phenomena, some of which can be exploited in optoelectronic devices based on graphene. In particular, the efficient and ultrafast generation of an electron distribution with an elevated electron temperature and the concomitant generation of a photo-thermoe... | 10.1088/0953-8984/27/16/164207 | 25,835,338 | Journal of physics. Condensed matter : an Institute of Physics journal | 2,015 | ||
Transcriptome Meta-Analysis Deciphers a Dysregulation in Immune Response-Associated Gene Signatures during Sepsis. | Sepsis is a life-threatening disease induced by a systemic inflammatory response, which leads to organ dysfunction and mortality. In sepsis, the host immune response is depressed and unable to cope with infection; no drug is currently available to treat this. The lungs are frequently the starting point for sepsis. This... | 10.3390/genes10121005 | 31,817,302 | D001119:Arginase; D005786:Gene Expression Regulation; D006801:Humans; D019272:Leukocyte Elastase; D020780:Matrix Metalloproteinase 9; D009195:Peroxidase; D053574:Receptors, Interleukin-1 Type II; D018805:Sepsis; D059467:Transcriptome | Genes | 2,019 | C508592:IL1R2 protein, human; D053574:Receptors, Interleukin-1 Type II; C000628728:MPO protein, human; D009195:Peroxidase; C000628800:ELANE protein, human; D019272:Leukocyte Elastase; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; D001119:Arginase |
IR analysis of crystalline samples of some urea derivatives. | The dependence of an IR spectrum of crystal samples of allantoin, barbital, chloroethylaminouracil (dopan), carbromal, 5-allyl-5-(beta-hydroxypropyl)-barbituric acid (ipronal) and theophyllin upon the method of crystals preparation was found after 3 months storage of crystals. There were no differences in the case of m... | 241,982 | D000481:Allantoin; D001462:Barbital; D001463:Barbiturates; D003460:Crystallization; D008617:Mephenytoin; D013055:Spectrophotometry, Infrared; D013806:Theophylline; D014508:Urea | Polish journal of pharmacology and pharmacy | 1,975 | D001463:Barbiturates; D000481:Allantoin; D001462:Barbital; D014508:Urea; D013806:Theophylline; D008617:Mephenytoin | |
[Arterial hypertension in psychopathological states of an endogenous nature]. | The article describes the features and character of hypertension in certain psychopathological, mainly hypochondriac, states in an endogenous psychic disease. It is shown that the subjective pathopsychological state, the patients' complaints and functional vegetovascular disorders differ from those observed in patients... | 502,170 | D003937:Diagnosis, Differential; D004244:Dizziness; D004562:Electrocardiography; D006261:Headache; D006339:Heart Rate; D006801:Humans; D006973:Hypertension; D006998:Hypochondriasis; D010554:Personality Disorders; D011599:Psychopathology | Kardiologiia | 1,979 | ||
A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height. | OBJECTIVE
A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, age-related decline of serum IGF-I levels, body height, birth weight and intima media thickness in hypertensive subjects.
DESIGN AND METHODS
We investigated the association between the length of the IGF-I ... | 10.1111/j.1365-2265.2004.02078.x | 15,272,914 | D000241:Adenosine; D000368:Aged; D000483:Alleles; D001827:Body Height; D001835:Body Weight; D015331:Cohort Studies; D003596:Cytosine; D005260:Female; D006720:Homozygote; D006801:Humans; D007334:Insulin-Like Growth Factor I; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012091:Repetiti... | Clinical endocrinology | 2,004 | D007334:Insulin-Like Growth Factor I; D003596:Cytosine; D000241:Adenosine |
Fano resonances in nanoscale plasmonic systems: a parameter-free modeling approach. | The interaction between plasmonic resonances, sharp modes, and light in nanoscale plasmonic systems often leads to Fano interference effects. This occurs because the plasmonic excitations are usually spectrally broad and the characteristic narrow asymmetric Fano line-shape results upon interaction with spectrally sharp... | 10.1021/nl201207n | 21,635,012 | D006046:Gold; D008027:Light; D053768:Metal Nanoparticles; D036103:Nanotechnology; D010316:Particle Size; D019904:Polymethyl Methacrylate; D020349:Surface Plasmon Resonance; D013499:Surface Properties | Nano letters | 2,011 | D006046:Gold; D019904:Polymethyl Methacrylate |
Cryptococcus infection in a non-HIV patient: a case report. | Cryptococcal infections are fungal infections most commonly seen in immunocompromised patients. Chronic high-dose steroid may precipitate such an immunocompromised state and thus create susceptibility to fungal infections. Cryptococcus neoformans is a saprophyte usually found in soil contaminated with pigeon droppings.... | 10.3402/jchimp.v2i3.19254 | 23,882,378 | Journal of community hospital internal medicine perspectives | 2,012 | ||
Patterns of relapse and associated cost burden in schizophrenia patients receiving atypical antipsychotics. | OBJECTIVE
To identify relapse in schizophrenia and the main cost drivers of relapse using a cost-based algorithm.
METHODS
Multi-state Medicaid data (1997-2010) were used to identify adults with schizophrenia receiving atypical antipsychotics (AP). The first schizophrenia diagnosis following AP initiation was defined ... | 10.3111/13696998.2013.841705 | 24,006,903 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D014150:Antipsychotic Agents; D005260:Female; D005102:Health Expenditures; D006296:Health Services; D006801:Humans; D015994:Incidence; D007345:Insurance Claim Review; D008297:Male; D008484:Medicaid; D008875:Middle Aged; D012008:Recurrence; D012189:Ret... | Journal of medical economics | 2,013 | D014150:Antipsychotic Agents |
Intergeneric Protoplast Fusion between Ruminococcus albus and an Anaerobic Recombinant, FE7. | Intergeneric protoplast fusion between Ruminococcus albus, a cellulolytic, gram-positive, anaerobic bacterium (Pc Sm Km), and an anaerobic recombinant, FE7 (Pc Sm Km), having lignin-related compound-degrading activities, was performed under strictly anaerobic conditions to introduce cellulase genes into strain FE7. The... | 10.1128/aem.54.5.1249-1253.1988 | 16,347,634 | Applied and environmental microbiology | 1,988 | ||
An optimization formulation for characterization of pulsatile cortisol secretion. | Cortisol is released to relay information to cells to regulate metabolism and reaction to stress and inflammation. In particular, cortisol is released in the form of pulsatile signals. This low-energy method of signaling seems to be more efficient than continuous signaling. We hypothesize that there is a controller in ... | 10.3389/fnins.2015.00228 | 26,321,898 | Frontiers in neuroscience | 2,015 | ||
Development of an isotoxic decision support system integrating genetic markers of toxicity for the implantation of a rectum spacer. | INTRODUCTION
Previous studies revealed that dose escalated radiotherapy for prostate cancer patients leads to higher tumor control probabilities (TCP) but also to higher rectal toxicities. An isotoxic model was developed to maximize the given dose while controlling the toxicity level. This was applied to analyze the ef... | 10.1080/0284186X.2018.1484156 | 29,952,681 | D003661:Decision Support Techniques; D019583:Dose Fractionation, Radiation; D005819:Genetic Markers; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D059351:Organ Sparing Treatments; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms; D019736:Prostheses and Implants... | Acta oncologica (Stockholm, Sweden) | 2,018 | D005819:Genetic Markers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate |
Design and development of artemisinin and dexamethasone loaded topical nanodispersion for the effective treatment of age-related macular degeneration. | Age-related macular degeneration (AMD) is a disease affecting the macula by the new blood vessels formation. AMD is widely treated with a combination of anti-angiogenic and anti-vascular endothelial growth factor (VEGF) agents. The topical administration of nanodispersions showed enhanced ocular residence time with con... | 10.1049/iet-nbt.2019.0130 | 31,625,529 | D000287:Administration, Topical; D020533:Angiogenesis Inhibitors; D000818:Animals; D037621:Artemisinins; D003315:Cornea; D003907:Dexamethasone; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D015195:Drug Design; D000076722:Drug Development; D004353:Drug Evaluation, Pr... | IET nanobiotechnology | 2,019 | D020533:Angiogenesis Inhibitors; D037621:Artemisinins; D004337:Drug Carriers; D013501:Surface-Active Agents; D020442:Poloxamer; D003907:Dexamethasone; C031327:artemisinin; D011205:Povidone |
Correlation among Poincare plot and traditional heart rate variability indices in adults with different risk levels of metabolic syndrome: a cross-sectional approach from Southern India. | OBJECTIVES
Heart rate variability (HRV) is an important marker of cardiac autonomic modulation. Metabolic syndrome (MetS) can alter cardiac autonomic modulation, raising the risk of cardiovascular disease (CVD). Poincaré plot analysis (PPA) is a robust scatter plot-based depiction of HRV and carries similar information... | 10.1515/jbcpp-2022-0208 | 36,626,361 | D006801:Humans; D000328:Adult; D006339:Heart Rate; D024821:Metabolic Syndrome; D001341:Autonomic Nervous System; D007194:India | Journal of basic and clinical physiology and pharmacology | 2,023 | |
A study on canine dirofilariasis in selected areas of Sri Lanka. | OBJECTIVES
Canine dirofilariasis is a mosquito borne zoonotic filarial parasitic disease caused by Dirofilaria species. In Sri Lanka, human dirofilariasis is endemic and well documented. Even though canine dirofilariasis is an established infection among dog populations in Sri Lanka, the prevalence and risk factors wer... | 10.1186/s13104-022-06024-0 | 35,421,998 | D000818:Animals; D004183:Dirofilaria immitis; D060348:Dirofilaria repens; D004184:Dirofilariasis; D004283:Dog Diseases; D004285:Dogs; D015995:Prevalence; D013188:Sri Lanka | BMC research notes | 2,022 | |
The Neocortex of Indian River Dolphins (Genus Platanista): Comparative, Qualitative and Quantitative Analysis. | We investigated the morphology of four primary neocortical projection areas (somatomotor, somatosensory, auditory, visual) qualitatively and quantitatively in the Indian river dolphins (Platanista gangetica gangetica, P. gangetica minor) with histological and stereological methods. For comparison, we included brains of... | 10.1159/000448274 | 27,732,977 | D000818:Animals; D001303:Auditory Cortex; D050681:Bottle-Nosed Dolphin; D002452:Cell Count; D004289:Dolphins; D007194:India; D019579:Neocortex; D045483:Rivers; D013045:Species Specificity | Brain, behavior and evolution | 2,016 | |
Computed Tomography in the evaluation of seizures at the University Hospital of the West Indies. | A retrospective evaluation of the Computed Tomography (CT) findings in three hundred and forty-four patients with seizures, presenting over a one-year period, was carried out to determine the value of this examination in the assessment of these patients. Eighty-four per cent of patients had non-contrast studies only. O... | 11,677,915 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain; D002648:Child; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012640:Seizures; D014057:Tomography, X-Ray Computed | The West Indian medical journal | 2,001 | D003287:Contrast Media | |
Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1α. | In this study, rat models of acute kidney injury (AKI) induced by renal ischemia-reperfusion (I/R) and HK-2 cell models of hypoxia-reoxygenation (H/R) were established to investigate the expression of inhibitor of DNA binding 1 (ID1) in AKI, and the regulation relationship between ID1 and hypoxia-inducible factor 1 alp... | 10.1155/2016/4634386 | 27,127,787 | D058186:Acute Kidney Injury; D000818:Animals; D015687:Cell Hypoxia; D004195:Disease Models, Animal; D004847:Epithelial Cells; D015870:Gene Expression; D020868:Gene Silencing; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051798:Inhibitor of Differentiation Protein 1; D007686:Kidney Tubules, Distal... | BioMed research international | 2,016 | C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C497454:ID1 protein, rat; D051798:Inhibitor of Differentiation Protein 1; D012333:RNA, Messenger |
The transcriptional response to the olive fruit fly (Bactrocera oleae) reveals extended differences between tolerant and susceptible olive (Olea europaea L.) varieties. | The olive fruit fly Bactrocera oleae (Diptera: Tephritidae) is the most devastating pest of cultivated olive (Olea europaea L.). Intraspecific variation in plant resistance to B. oleae has been described only at phenotypic level. In this work, we used a transcriptomic approach to study the molecular response to the oli... | 10.1371/journal.pone.0183050 | 28,797,083 | D000818:Animals; D005638:Fruit; D018506:Gene Expression Regulation, Plant; D006790:Host-Parasite Interactions; D053858:Metabolic Networks and Pathways; D031658:Olea; D010935:Plant Diseases; D033621:Tephritidae; D059467:Transcriptome | PloS one | 2,017 | |
Gene expression panel predicts metastatic-lethal prostate cancer outcomes in men diagnosed with clinically localized prostate cancer. | Prognostic biomarkers are needed to distinguish patients with clinically localized prostate cancer (PCa) who are at high risk of metastatic progression. The tumor transcriptome may reveal its aggressiveness potential and have utility for predicting adverse patient outcomes. Genomewide gene expression levels were measur... | 10.1002/1878-0261.12014 | 28,145,099 | D000328:Adult; D014408:Biomarkers, Tumor; D030561:Databases, Nucleic Acid; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011468:Prostatectomy; D011471:Prostatic Neoplasms; D012333:RNA, Messenger; D012334:RNA, N... | Molecular oncology | 2,017 | D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D012334:RNA, Neoplasm |
Characterization of ribonucleic acid polymerase-T7 promoter binary complexes. | Several experimental approaches have been employed to independently determine rates of dissociation for Escherichia coli RNA polymerase from the T7 bacteriophage A1, A2, A3, and D promoters. Heparin challenge measurements employing abortive initiation turnover rates as an index of promoter occupancy were carried out ov... | 10.1021/bi00552a023 | 6,992,860 | D012321:DNA-Directed RNA Polymerases; D004926:Escherichia coli; D006493:Heparin; D007700:Kinetics; D009876:Operon; D011067:Poly dA-dT; D011485:Protein Binding; D013604:T-Phages; D013698:Templates, Genetic; D014158:Transcription, Genetic | Biochemistry | 1,980 | D011067:Poly dA-dT; D006493:Heparin; D012321:DNA-Directed RNA Polymerases |
Elevated endothelin-1 level is a risk factor for nonocclusive mesenteric ischemia. | OBJECTIVE
Nonocclusive mesenteric ischemia may occur after cardiac surgery, commonly in conjunction with the use of cardiopulmonary bypass. Some evidence suggests that endothelin-1 serum levels are increased in patients with mesenteric ischemia, but the association of endothelin-1 and nonocclusive mesenteric ischemia h... | 25,623,906 | D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D016009:Chi-Square Distribution; D019332:Endothelin-1; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D065666:Mesenteric Ischemia; D008875:Middle Aged; D016017:Odds Ra... | The Journal of thoracic and cardiovascular surgery | 2,015 | D015415:Biomarkers; D019332:Endothelin-1 | |
High-Mobility Holes in Dual-Gated WSe2 Field-Effect Transistors. | We demonstrate dual-gated p-type field-effect transistors (FETs) based on few-layer tungsten diselenide (WSe2) using high work-function platinum source/drain contacts and a hexagonal boron nitride top-gate dielectric. A device topology with contacts underneath the WSe2 results in p-FETs with ION/IOFF ratios exceeding 1... | 10.1021/acsnano.5b04611 | 26,343,531 | ACS nano | 2,015 | ||
Circadian response of annual weeds to glyphosate and glufosinate. | Five field experiments were conducted in 1998 and 1999 in Minnesota to examine the influence of time of day efficacy of glyphosate [N-(phosphonomethyl)glycine] and glufosinate [2-amino-4-(hydroxymethyl-phosphinyl)butanoic acid] applications on the control of annual weeds. Each experiment was designed to be a randomized... | 10.1081/cbi-120002877 | 12,025,933 | D000613:Aminobutyrates; D002940:Circadian Rhythm; D005998:Glycine; D006540:Herbicides; D010944:Plants; D000097797:Glyphosate | Chronobiology international | 2,002 | D000613:Aminobutyrates; D006540:Herbicides; C003121:phosphinothricin; D005998:Glycine |
Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission. | BACKGROUND
Previous studies have demonstrated that single HIV-1 genotypes are commonly transmitted from mother to child, but such analyses primarily used single samples from mother and child. It is possible that in a single sample, obtained early after infection, only the most replication competent virus is detected ev... | 10.1186/s12977-015-0222-0 | 26,573,574 | D019143:Evolution, Molecular; D005260:Female; D015752:Genes, env; D014644:Genetic Variation; D016679:Genome, Viral; D015658:HIV Infections; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D009035:Mothers; D010802:Phylogeny; D011247:Pregnancy; D0... | Retrovirology | 2,015 | |
Effect of mitochondrial electron transport chain inhibitors on superoxide radical generation in rat hippocampal and striatal slices. | In this study, we have compared the generation of superoxide radical in rat hippocampal and striatal slices in the presence of specific mitochondrial electron transport chain (ETC) inhibitors (complexes I and III) under control and depolarization conditions [incubation in artificial cerebrospinal fluid (ACSF) or depola... | 10.1089/152308601317203602 | 11,813,983 | D000818:Animals; D000900:Anti-Bacterial Agents; D000968:Antimycin A; D001921:Brain; D004579:Electron Transport; D005609:Free Radicals; D006624:Hippocampus; D007770:L-Lactate Dehydrogenase; D008928:Mitochondria; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D012402:Rotenone; D013481:Superoxides; ... | Antioxidants & redox signaling | 2,001 | D000900:Anti-Bacterial Agents; D005609:Free Radicals; D014475:Uncoupling Agents; D012402:Rotenone; D013481:Superoxides; D000968:Antimycin A; D007770:L-Lactate Dehydrogenase |
Bilaterally Symmetrical Lower Extremity Compartment Syndrome following Massive Transfusion. | Compartment syndrome is a serious condition characterized by raised intracompartmental pressure, which develops following trauma. Well leg compartment syndrome (WLCS) is a term reserved for compartment syndrome in a nontraumatic setting, usually resulting from prolonged lithotomy position during surgery. In literature,... | 10.1155/2016/2718421 | 26,885,421 | Case reports in orthopedics | 2,016 | ||
Stakeholder Perspectives on the Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) Project. | Background and Objectives
The need to reduce burdensome and costly hospitalizations of frail nursing home residents is well documented. The Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project achieved this reduction through a multicompone... | 10.1093/geront/gnx155 | 29,045,609 | D032722:Advance Care Planning; D006760:Hospitalization; D006801:Humans; D007324:Institutional Management Teams; D007407:Interviews as Topic; D008134:Long-Term Care; D009735:Nursing Homes; D010166:Palliative Care; D010360:Patient Transfer; D036301:Qualitative Research; D058996:Quality Improvement; D013727:Terminal Care | The Gerontologist | 2,018 | |
Characteristics of within-household varicella transmission events associated with school outbreaks in Shanghai, China, 2009-2018. | Transmission of varicella occurs frequently in schools and households. We investigated the characteristics of varicella cases derived from within-household transmission and the modes of varicella transmission between school and household settings in Shanghai, China, from 2009 to 2018. Within-household transmission occu... | 10.1017/S0950268820000448 | 32,054,550 | D000293:Adolescent; D000328:Adult; D002644:Chickenpox; D002648:Child; D002675:Child, Preschool; D002681:China; D004196:Disease Outbreaks; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012574:Schools; D055815:Young Adult | Epidemiology and infection | 2,020 | |
Organelle-specific expression of subunit ND5 of human complex I (NADH dehydrogenase) alters cation homeostasis in Saccharomyces cerevisiae. | The ND5 component of the respiratory complex I is a large, hydrophobic subunit encoded by the mitochondrial genome. Its bacterial homologue, the NDH-1 subunit NuoL, acts as a cation transporter in the absence of other NDH-1 subunits. Mutations in human ND5 are frequently observed in neurodegenerative diseases. Wild typ... | 10.1111/j.1567-1364.2010.00643.x | 20,528,953 | D000595:Amino Acid Sequence; D002412:Cations; D042967:Electron Transport Complex I; D004721:Endoplasmic Reticulum; D006706:Homeostasis; D006801:Humans; D007150:Immunohistochemistry; D008856:Microscopy, Fluorescence; D008928:Mitochondria; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D009245:NADH Dehy... | FEMS yeast research | 2,010 | D002412:Cations; D024101:Mitochondrial Proteins; D021122:Protein Subunits; D011994:Recombinant Proteins; D012964:Sodium; C481838:MT-ND5 protein, human; D009245:NADH Dehydrogenase; D042967:Electron Transport Complex I; D011188:Potassium |
NLRP3 Inflammasome Simultaneously Involved in Autophagy and Phagocytosis of THP-1 Cells to Clear Aged Erythrocytes. | Autophagy and phagocytosis are two important processes that capture and digest materials found in cellular interiors and exteriors, respectively. Aged red blood cells (RBCs) are cleared by phagocytes in vivo. We focused on determining whether autophagy occurs after phagocytes swallow sunset erythrocytes, and whether th... | 10.1155/2022/1481154 | 36,213,328 | D001343:Autophagy; D000071183:Autophagy-Related Proteins; D016207:Cytokines; D004912:Erythrocytes; D006801:Humans; D058847:Inflammasomes; D008869:Microtubule-Associated Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D010587:Phagocytosis; D020123:Sirolimus; D000074084:THP-1 Cells | Journal of immunology research | 2,022 | D000071183:Autophagy-Related Proteins; D016207:Cytokines; D058847:Inflammasomes; D008869:Microtubule-Associated Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D020123:Sirolimus |
Cyclosporine can increase isoflurane MAC. | UNLABELLED
Previous reports indicate that cyclosporine increases sleeping time from barbiturate administration, and analgesia from fentanyl administration, suggesting a possible contribution of cyclosporine to anesthesia. Accordingly, we determined whether cyclosporine pretreatment decreases isoflurane MAC (the minimum... | 10.1097/00000539-200210000-00025 | 12,351,270 | D018686:Anesthetics, Intravenous; D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D016572:Cyclosporine; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007166:Immunosuppressive Agents; D007530:Isoflurane; D010147:Pain Measurement; D011650:Pulmonary Alveo... | Anesthesia and analgesia | 2,002 | D018686:Anesthetics, Intravenous; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D007530:Isoflurane |
Inhibitors of oxidative degradation of protein: gerontological implications. | Compounds were studied that inhibit the oxidative degradation of human serum albumin by peroxidase and the enzyme model, iron hydroxide. Differences between the two oxidants gave clues for the mechanism of inhibition. The inhibitors studied were inorganic anions, phosphate, sulfate, carbonate and molybdate; organic ani... | 10.1007/BF00777554 | 440,299 | D000375:Aging; D000838:Anions; D002254:Carbonates; D003651:Decanoates; D003652:Decanoic Acids; D006000:Glycocholic Acid; D006003:Glycogen; D006801:Humans; D010544:Peroxidases; D010710:Phosphates; D012709:Serum Albumin; D013431:Sulfates | Molecular biology reports | 1,979 | D000838:Anions; D002254:Carbonates; D003651:Decanoates; D003652:Decanoic Acids; D010710:Phosphates; D012709:Serum Albumin; D013431:Sulfates; D006003:Glycogen; D010544:Peroxidases; D006000:Glycocholic Acid |
[Iliofascial versus epidural block during hip endoprosthesis]. | UNLABELLED
The study was carried out to compare analgesia, the side-effects incidence and the need for analgetics when you use the continuous iliofascial block (CIFB) versus epidural analgesia (EA) after the total hip joint endoprosthesis (THJEP). 60 patients undergoing planned THJEP under spinal anaesthesia were inclu... | 22,993,917 | D015360:Analgesia, Epidural; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D019644:Arthroplasty, Replacement, Hip; D001340:Autonomic Nerve Block; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain M... | Anesteziologiia i reanimatologiia | 2,012 | D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D014147:Tramadol | |
Reporting mid- and long-term results of endovascular grafting for abdominal aortic aneurysms using the aortomonoiliac configuration. | PURPOSE
This study evaluated the feasibility, efficacy, and durability of a specific aortomonoiliac endograft for the treatment of abdominal aortic aneurysm (AAA) during a midterm follow-up.
METHODS
From January 2002 until November 2008, 106 patients (6 women; mean age, 73.37 +/- 7.39 years) were treated for an AAA u... | 10.1016/j.jvs.2008.12.054 | 19,563,949 | D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta; D017544:Aortic Aneurysm, Abdominal; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007083:Iliac Artery; D008297:Male; D012189:Retrospective Stu... | Journal of vascular surgery | 2,009 | |
How Japanese adults perceive memory change with age: middle-aged adults with memory performance as high as young adults evaluate their memory abilities as low as older adults. | The characteristics of self-referent beliefs about memory change with age. The relationship between beliefs and memory performance of three age groups of Japanese adults was investigated. The beliefs measured by the Personal Beliefs about Memory Instrument (Lineweaver & Hertzog, 1998) differed among the age groups and ... | 10.2190/AG.78.1.e | 24,669,510 | D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D005260:Female; D006803:Human Development; D006801:Humans; D007564:Japan; D008297:Male; D008569:Memory Disorders; D011939:Mental Recall; D008875:Middle Aged; D011581:Psychological Tests; D011587:Psychology, Comparative; D020377:Self Efficacy; D012647:Self... | International journal of aging & human development | 2,014 | |
The lack of a role for protein kinase C in neurite extension and in the induction of ornithine decarboxylase by nerve growth factor in PC12 cells. | Nerve growth factor (NGF) causes pheochromocytoma cells (PC12) to undergo a number of physiological changes which mimic the differentiated neuronal cell, including neurite extension. We have examined protein kinase C (Ca2+/phospholipid-dependent enzyme) as a potential signaling mechanism in NGF-stimulated neurite outgr... | 2,914,963 | D000310:Adrenal Gland Neoplasms; D001369:Axons; D003513:Cycloheximide; D003609:Dactinomycin; D004357:Drug Synergism; D004790:Enzyme Induction; D007700:Kinetics; D009154:Mutation; D009414:Nerve Growth Factors; D009474:Neurons; D009955:Ornithine Decarboxylase; D010673:Pheochromocytoma; D011493:Protein Kinase C; D015290:S... | The Journal of biological chemistry | 1,989 | D009414:Nerve Growth Factors; D003609:Dactinomycin; D003513:Cycloheximide; D011493:Protein Kinase C; D009955:Ornithine Decarboxylase; D013110:Sphingosine; D013755:Tetradecanoylphorbol Acetate | |
Gamma-Hydroxybutyrate content in dried bloodspots facilitates newborn detection of succinic semialdehyde dehydrogenase deficiency. | Increased gamma-hydroxybutyric acid in urine and blood are metabolic hallmarks of succinic semialdehyde dehydrogenase deficiency, a defect of 4-aminobutyric acid metabolism. Here, we examined the hypothesis that succinic semialdehyde dehydrogenase deficiency could be identified via measurement of gamma-hydroxybutyric a... | 10.1016/j.ymgme.2019.07.010 | 31,345,667 | D000293:Adolescent; D000328:Adult; D000592:Amino Acid Metabolism, Inborn Errors; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities; D059788:Dried Blood Spot Testing; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D012978:Sodiu... | Molecular genetics and metabolism | 2,019 | D012978:Sodium Oxybate; D050644:Succinate-Semialdehyde Dehydrogenase |
The protective effects of the antioxidant N-acetylcysteine (NAC) against oxidative stress-associated apoptosis evoked by the organophosphorus insecticide malathion in normal human astrocytes. | Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxida... | 10.1016/j.tox.2019.02.004 | 30,769,050 | D000111:Acetylcysteine; D000975:Antioxidants; D017209:Apoptosis; D001253:Astrocytes; D002470:Cell Survival; D019610:Cytoprotection; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007306:Insecticides; D008294:Malathion; D009943:Organophosphorus Compounds; D018384:Oxidative Stress | Toxicology | 2,019 | D000975:Antioxidants; D007306:Insecticides; D009943:Organophosphorus Compounds; D008294:Malathion; D000111:Acetylcysteine |
The continuing saga of the marine polyether biotoxins. | The unprecedented structure of the marine natural product brevetoxin B was elucidated by the research group of Nakanishi and Clardy in 1981. The ladderlike molecular architecture of this fused polyether molecule, its potent toxicity, and fascinating voltage-sensitive sodium channel based mechanism of action immediately... | 10.1002/anie.200801696 | 18,763,702 | D000818:Animals; D002922:Ciguatoxins; D003500:Cyclization; D004987:Ethers; D008387:Marine Toxins; D015394:Molecular Structure; D035964:Oxocins | Angewandte Chemie (International ed. in English) | 2,008 | D004987:Ethers; D008387:Marine Toxins; D035964:Oxocins; C435770:gambierol; D002922:Ciguatoxins; C043466:brevetoxin B; C020394:maitotoxin |
Single Biosensor for Simultaneous Quantification of Glucose and pH in a Rat Brain of Diabetic Model Using Both Current and Potential Outputs. | Glucose and pH are two important indicators of diabetes mellitus. However, their dynamic changes at the same time in brain are still not clear, mainly due to a lack of a single biosensor capable of simultaneous quantification of two species in a live rat brain. In this work, a selective and sensitive ratiometric electr... | 10.1021/acs.analchem.7b00881 | 28,560,874 | D000818:Animals; D015374:Biosensing Techniques; D001923:Brain Chemistry; D002244:Carbon; D003921:Diabetes Mellitus, Experimental; D005947:Glucose; D006863:Hydrogen-Ion Concentration; D008297:Male; D008839:Microelectrodes; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties | Analytical chemistry | 2,017 | D002244:Carbon; D005947:Glucose |
Low cerebral blood flow after cardiac arrest is not associated with anaerobic cerebral metabolism. | AIM OF THE STUDY
Estimation of cerebral anaerobic metabolism in survivors and non-survivors after cardiac arrest.
METHODS
We performed an observational study in twenty comatose patients after cardiac arrest and 19 healthy control subjects. We measured mean flow velocity in the middle cerebral artery (MFVMCA) by trans... | 10.1016/j.resuscitation.2017.08.218 | 28,844,934 | D000368:Aged; D000693:Anaerobiosis; D000704:Analysis of Variance; D016887:Cardiopulmonary Resuscitation; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D003128:Coma; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery; D0586... | Resuscitation | 2,017 | D010100:Oxygen |
Relationship between leukocyte population and nutritive conditions in dairy herds with frequently appearing mastitis. | To clarify the relationship between cellular immune status and nutritive condition, feeding program, blood profiles, and leukocyte populations were analyzed in two dairy herds experiencing frequent mastitis. Fourteen of the 35 lactating cows in herd A, and 18 of the 50 lactating cows in herd B scored positive on the Ca... | 10.1292/jvms.68.113 | 16,520,531 | D000818:Animals; D001786:Blood Glucose; D001798:Blood Proteins; D001806:Blood Urea Nitrogen; D017252:CD3 Complex; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D002417:Cattle; D002784:Cholesterol; D003612:Dairying; D005260:Female; D006400:Hematocrit; D007774:Lactation; D007958:Leukocyte Count;... | The Journal of veterinary medical science | 2,006 | D001786:Blood Glucose; D001798:Blood Proteins; D017252:CD3 Complex; D018950:Lipopolysaccharide Receptors; D002784:Cholesterol |
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