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A novel anatomical patellar plate for transverse patellar fracture - A biomechanical in-vitro study. | OBJECTIVE
The aim of this study was to assess the safety and stability of our novel anatomical patella plate and to compare its stability with tension band-wire technique.
METHODS
A total of 12 cadaveric preserved knees (six right and six left patellae) with close patellar size were chosen to form two groups of six s... | 10.1016/j.aott.2017.04.006 | 28,554,845 | D001696:Biomechanical Phenomena; D001860:Bone Plates; D005593:Fracture Fixation, Internal; D006801:Humans; D007593:Joint Instability; D007718:Knee Injuries; D008422:Materials Testing; D010329:Patella; D011183:Postoperative Complications; D011474:Prosthesis Design; D014025:Titanium | Acta orthopaedica et traumatologica turcica | 2,017 | D014025:Titanium |
Two Pex5 Proteins With Different Cargo Specificity Are Critical for Peroxisome Function in Ustilago maydis. | Peroxisomes are dynamic multipurpose organelles with a major function in fatty acid oxidation and breakdown of hydrogen peroxide. Many proteins destined for the peroxisomal matrix contain a C-terminal peroxisomal targeting signal type 1 (PTS1), which is recognized by tetratricopeptide repeat (TPR) proteins of the Pex5 ... | 10.3389/fcell.2022.858084 | 35,646,929 | Frontiers in cell and developmental biology | 2,022 | ||
Factors that influence formation of sister chromatid exchanges in human blood lymphocytes. | Sister chromatid exchange (SCE) reflects an interchange of DNA sequences between helices in a replicating chromosome. This was initially accomplished by Taylor and colleagues (1957) using tritiated thymidine incorporation followed by autoradiography. The development of an elegant technique for differential staining of ... | 10.3109/10408448809040817 | 3,056,658 | D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes; D012854:Sister Chromatid Exchange | Critical reviews in toxicology | 1,988 | |
The usefulness of echocardiography in the surgical management of infants with congenital heart disease. | Between January 1988 and August 1991, at The Children's Heart Center, Atlanta, 83 infants with congenital heart defects were diagnosed by echocardiography and underwent surgery without cardiac catheterization. The diagnostic categories included 46 infants with left heart obstructive lesions, 19 infants with cyanotic he... | 10.1002/clc.4960151208 | 1,282,097 | D001017:Aortic Coarctation; D001024:Aortic Valve Stenosis; D006328:Cardiac Catheterization; D003490:Cyanosis; D004374:Ductus Arteriosus, Patent; D004452:Echocardiography; D015150:Echocardiography, Doppler; D006330:Heart Defects, Congenital; D006331:Heart Diseases; D006345:Heart Septal Defects, Ventricular; D006801:Huma... | Clinical cardiology | 1,992 | |
[Falling due to vitamin B12 deficiency]. | BACKGROUND
Ataxia due to a vitamin B12 deficiency can be a cause of falls in elderly patients.
CASE DESCRIPTION
An 86-year-old woman presented with functional decline and gait problems. She had been falling regularly. The patient's gait was ataxic and she was unable to stand without support. Additional laboratory tes... | 23,302,349 | D000058:Accidental Falls; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D016896:Treatment Outcome; D014805:Vitamin B 12; D014806:Vitamin B 12 Deficiency; D014803:Vitamin B Complex | Nederlands tijdschrift voor geneeskunde | 2,013 | D014803:Vitamin B Complex; D014805:Vitamin B 12 | |
Circulating adiponectin levels in type 2 diabetes mellitus patients with or without non-alcoholic fatty liver disease: Results of a small, open-label, randomized controlled intervention trial in a subgroup receiving short-term exenatide. | AIM
Diabetes mellitus type 2 (DMT2) and non-alcoholic fatty liver disease (NAFLD) are both characterized by decreased circulating adiponectin. Recently, glucagon-like peptide-1 receptor agonists have been shown to induce adiponectin's expression. However, their interaction on clinical grounds needs to be further elucid... | 26,803,355 | D052242:Adiponectin; D000368:Aged; D001786:Blood Glucose; D002097:C-Reactive Protein; D003924:Diabetes Mellitus, Type 2; D000077270:Exenatide; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D007004:Hypoglycemic Agents; D007328:Insulin; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting; D008297:Mal... | Diabetes research and clinical practice | 2,016 | C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D006442:Glycated Hemoglobin A; D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting; D010455:Peptides; D014688:Venoms; D000069036:Insulin Glargine; D002097:C-Reactive Protein; D000077270:Exenatide | |
Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling. | Microglia activation and associated inflammatory response are involved in the pathogenesis of different neurodegenerative diseases. We have reported that Notch-1 and NF-κB/p65 signalling pathways operate in synergy in regulating the production of proinflammatory mediators in activated microglia. In the latter, there is... | 10.1371/journal.pone.0186764 | 29,049,420 | D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D004151:Dipeptides; D005455:Fluorescent Antibody Technique; D000071679:Glycogen Synthase Kinase 3 beta; D018836:Inflammation Mediators; D018021:Lithium Chloride; D051379:Mice; D017628:Microglia; D016328:NF-kappa B; D012333:RNA, Messenger; D051881:Receptor, ... | PloS one | 2,017 | D004151:Dipeptides; D018836:Inflammation Mediators; C000624602:N-((3,5-difluorophenyl)acetyl)alanyl-2-phenylglycine-1,1-dimethylethyl ester; D016328:NF-kappa B; C497762:Notch1 protein, mouse; D012333:RNA, Messenger; D051881:Receptor, Notch1; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; D... |
Effects of SO2 exposure on canine pulmonary epithelial functions. | We examined the effects of a single exposure of high concentrations of sulfur dioxide (SO2) on the pulmonary epithelium in adult dogs over a period of several weeks. Mucociliary tracheal transport rates and alveolar clearance of 99mTc-labeled diethylene triamine pentacetate (99mTcO4-) were measured in vivo, before and ... | 10.3109/01902148909087852 | 2,651,101 | D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D004285:Dogs; D004848:Epithelium; D008168:Lung; D008855:Microscopy, Electron, Scanning; D009079:Mucociliary Clearance; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013458:Sulfur Dioxide; D013667:Technetium; D016284:Technetium Tc 99m Pen... | Experimental lung research | 1,989 | D000336:Aerosols; D009942:Organometallic Compounds; D013458:Sulfur Dioxide; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate |
Graded increase in probability of eosinophilic differentiation of HL-60 promyelocytic leukemia cells induced by culture under alkaline conditions. | HL-60 cells differentiate primarily to eosinophils instead of neutrophils when cultured with butyric acid if they have previously been cultured under alkaline conditions (pH 7.6). To determine the nature of the process by which this occurs, a group of single-cell derived clones was produced from HL-60 cells after prolo... | 10.1016/0145-2126(88)90103-8 | 3,184,985 | D000362:Agar; D002087:Butyrates; D020148:Butyric Acid; D002454:Cell Differentiation; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003470:Culture Media; D004804:Eosinophils; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015473:Leukemia, Promyelocytic, Acute; D011336:Probability; D014407:Tumor Cell... | Leukemia research | 1,988 | D002087:Butyrates; D003470:Culture Media; D020148:Butyric Acid; D000362:Agar |
Analysis of the first two waves of thymus homing stem cells and their T cell progeny in chick-quail chimeras. | Chick-quail chimeras were used to study precursor/progeny relationships of hemopoietic stem cells (SC) that enter the embryonic thymus in waves to give rise sequentially to the TCR-1+, TCR-2+, and TCR-3+ lineages of T cells. The first wave of SC and their progeny were examined by grafting thymus from 9-d chick embryos ... | 10.1084/jem.170.2.543 | 2,666,562 | D000367:Age Factors; D000818:Animals; D000911:Antibodies, Monoclonal; D002454:Cell Differentiation; D002465:Cell Movement; D002642:Chick Embryo; D002678:Chimera; D003370:Coturnix; D006412:Hematopoietic Stem Cells; D007124:Immunoenzyme Techniques; D013601:T-Lymphocytes; D013950:Thymus Gland | The Journal of experimental medicine | 1,989 | D000911:Antibodies, Monoclonal |
Lung parenchyma: magnetic susceptibility in MR imaging. | Magnetic susceptibility effects in magnetic resonance (MR) imaging of normal lung parenchyma occur because of magnetic-field inhomogeneities induced by the microscopic heterogeneity of the lung. The effects on MR imaging of the lung are loss of signal from intravoxel phase dispersion (measured with T2') and a shift in ... | 10.1148/radiology.180.3.1871305 | 1,871,305 | D006801:Humans; D066298:In Vitro Techniques; D008168:Lung; D008279:Magnetic Resonance Imaging; D008280:Magnetics | Radiology | 1,991 | |
Purinergic regulation of cholangiocyte secretion: identification of a novel role for P2X receptors. | The P2X family of ligand-gated cation channels is comprised of seven distinct isoforms activated by binding of extracellular purines. Although originally identified in neurons, there is increasing evidence for expression of P2X receptors in epithelia as well. Because ATP is released by both hepatocytes and cholangiocyt... | 10.1152/ajpgi.00325.2004 | 15,528,255 | D000255:Adenosine Triphosphate; D000818:Animals; D001646:Bile; D001653:Bile Ducts, Intrahepatic; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002712:Chlorides; D004594:Electrophysiology; D006801:Humans; D007150:Immunohistochemistry; D020033:Protein Isoforms; D012333:RNA, Messenger; D051381:Rats; D018048:Receptor... | American journal of physiology. Gastrointestinal and liver physiology | 2,005 | D002712:Chlorides; C548226:P2RX4 protein, human; C548228:P2rx4 protein, rat; D020033:Protein Isoforms; D012333:RNA, Messenger; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; D058848:Receptors, Purinergic P2X4; C033901:3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate; D000255:Adenosine Triphosphate |
Review on experimental research of herbal medicines with anti-amnesic activity. | Amnesia is characterized by the inability to form memories or total or partial loss of memory secondary to cerebral malfunction following degenerative diseases, cerebral infections, traumatic injuries and emotional events which could be differentiated from dementia. However, no effective treatment for amnesia is curren... | 10.1055/s-0029-1240707 | 20,033,863 | D000647:Amnesia; D000818:Animals; D028041:Centella; D020441:Ginkgo biloba; D006801:Humans; D032501:Huperzia; D018377:Neurotransmitter Agents; D008517:Phytotherapy; D010936:Plant Extracts; D010946:Plants, Medicinal | Planta medica | 2,010 | D018377:Neurotransmitter Agents; D010936:Plant Extracts |
Sequential release of milk protein-derived bioactive peptides in the jejunum in healthy humans. | BACKGROUND
The digestive hydrolysis of dietary proteins leads to the release of peptides in the intestinal tract, where they may exert a variety of functions, but their characterization and quantification are difficult.
OBJECTIVES
We aimed to characterize and determine kinetics of the formation of peptides present in... | 10.3945/ajcn.112.055202 | 23,576,048 | D000293:Adolescent; D000328:Adult; D002364:Caseins; D002853:Chromatography, Liquid; D004032:Diet; D004044:Dietary Proteins; D004063:Digestion; D004723:Endorphins; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007413:Intestinal Mucosa; D007583:Jejunum; D007700:Kinetics; D008297:Male; D062407:Meals; D008894:Milk P... | The American journal of clinical nutrition | 2,013 | D002364:Caseins; D004044:Dietary Proteins; D004723:Endorphins; D008894:Milk Proteins; D010455:Peptides; D000067816:Whey Proteins; C021968:beta-casomorphins; D009584:Nitrogen |
Unanswered questions about the 1918 influenza pandemic: origin, pathology, and the virus itself. | The influenza epidemic of 1918 represented the greatest failure of medical science in the 20th century. Fortunately, research throughout subsequent years has been making amends. Some studies have applied RT-PCR to the tissue samples from that time, whereas others have reconstructed the pathogen in its virulent state. B... | 10.1016/S1473-3099(18)30359-1 | 29,935,779 | D014943:Global Health; D049673:History, 20th Century; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D064149:Influenza Pandemic, 1918-1919; D014774:Virulence | The Lancet. Infectious diseases | 2,018 | |
Feeding traces attributable to juvenile Tyrannosaurus rex offer insight into ontogenetic dietary trends. | Theropod dinosaur feeding traces and tooth marks yield paleobiological and paleoecological implications for social interactions, feeding behaviors, and direct evidence of cannibalism and attempted predation. However, ascertaining the taxonomic origin of a tooth mark is largely dependent on both the known regional biost... | 10.7717/peerj.6573 | 30,863,686 | PeerJ | 2,019 | ||
Genetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosis. | Mutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis and cause Leber congenital amaurosis (LCA), a severe hereditary blindness occurring in early childhood. The pathology is attributed to a combination of 11-cis-retinal deficiency and photoreceptor degeneration. The mistraffick... | 10.1093/hmg/ddu588 | 25,416,279 | D000818:Animals; D004195:Disease Models, Animal; D059865:Endoplasmic Reticulum Stress; D017353:Gene Deletion; D057130:Leber Congenital Amaurosis; D051379:Mice; D021381:Protein Transport; D017949:Retinal Cone Photoreceptor Cells; D012162:Retinal Degeneration; D017299:Rod Opsins | Human molecular genetics | 2,015 | D017299:Rod Opsins; C095853:short-wavelength opsin |
Only early intervention with gamma-aminobutyric acid cell therapy is able to reverse neuropathic pain after partial nerve injury. | Pharmacological treatment for neuropathic pain, although often effective for brief periods, can result in intractable persistent pain with certain patients. Cell therapy for neuropathic pain is a newly developing technology useful for an examination of enhanced normal sensory function after nerve injury with the placem... | 10.1089/089771501750171092 | 11,336,447 | D000818:Animals; D017690:Cell Transplantation; D006358:Hot Temperature; D006930:Hyperalgesia; D006941:Hyperesthesia; D009409:Nerve Crush; D009474:Neurons; D010812:Physical Stimulation; D051381:Rats; D011920:Rats, Inbred WF; D012584:Sciatic Nerve; D013997:Time Factors; D014949:Wounds, Nonpenetrating; D005680:gamma-Amino... | Journal of neurotrauma | 2,001 | D005680:gamma-Aminobutyric Acid |
Application of ultrasound biomicroscopy in the planning of cataract surgery in anterior megalophthalmos. | Anterior megalophthalmos, a rare hereditary disorder, is macrocornea (horizontal corneal diameter more than 13 mm) in association with enlarged lens-iris diaphragm and ciliary ring. One of the major challenging issues in the cataract surgery of these patients is preventing intraocular lens (IOL) malposition, because of... | 10.4103/0301-4738.83625 | 21,836,354 | D000328:Adult; D000867:Anterior Chamber; D002387:Cataract Extraction; D003937:Diagnosis, Differential; D005124:Eye Abnormalities; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D033401:Microscopy, Acoustic; D011300:Preoperative Care; D015203:Reproducibility of Results | Indian journal of ophthalmology | 2,011 | |
[New experimental procedures in adult orthodontics]. | This presentation discusses a new approach to preprosthetic orthodontic treatment of adult patients with missing anterior teeth. The basic idea is: Prosthodontic appliances with high and lasting esthetic qualities are difficult to obtain in the anterior region. Our alternative is to close anterior gaps by orthodontic t... | 2,247,369 | D000328:Adult; D003481:Cuspid; D004955:Esthetics, Dental; D005260:Female; D006801:Humans; D007180:Incisor; D008297:Male; D008875:Middle Aged; D009971:Orthodontics, Corrective; D014087:Tooth Movement Techniques | Den Norske tannlaegeforenings tidende | 1,990 | ||
The stigma of mental illness in Arab families: a concept analysis. | ACCESSIBLE SUMMARY
The stigma of mental illness varies significantly from culture to culture and from person to person. To date, little is known about how mental illness stigma manifests within the Arab community. This study aimed at bringing clarity to the concept of 'mental illness stigma' as it applies to Arab famil... | 10.1111/jpm.12237 | 26,118,332 | D018912:Arabs; D006801:Humans; D001523:Mental Disorders; D036301:Qualitative Research; D057545:Social Stigma | Journal of psychiatric and mental health nursing | 2,015 | |
Aortic stenosis and right ventricular dysfunction. | Cardiac damage in severe aortic stenosis (AS) is not limited to the aortic valve and left ventricle, but is a systemic disease characterized by a significant alteration in cardiac structure and function. Therefore, a new classification of AS based on the degree of myocardial damage was proposed. A significant number of... | 34,275,314 | D001021:Aortic Valve; D001024:Aortic Valve Stenosis; D004452:Echocardiography; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles; D006801:Humans; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left; D018497:Ventricular Dysfunction, Right; D016277:Ventricular Function, Left | Vnitrni lekarstvi | 2,021 | ||
Characterization and functional properties of a novel monoclonal antibody which identifies a T cell receptor in chickens. | A monoclonal antibody, mAb6, was produced that specifically bound to chicken T lymphocytes. Immunofluorescence analysis using a fluorescence-activated cell sorter revealed that the antibody reacted with approximately 50% of blood lymphocytes and with approximately 40% of splenocytes and thymocytes. It did not react wit... | 10.1002/eji.1830180407 | 3,259,182 | D000818:Animals; D000911:Antibodies, Monoclonal; D000937:Antigen-Antibody Reactions; D002469:Cell Separation; D002645:Chickens; D003208:Concanavalin A; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell; D013601:T-Lymphocytes; D013602:T-Lymphocyte... | European journal of immunology | 1,988 | D000911:Antibodies, Monoclonal; D011948:Receptors, Antigen, T-Cell; D003208:Concanavalin A |
Modular Enantioselective Synthesis of cis-Cyclopropanes through Self-Sensitized Stereoselective Photodecarboxylation with Benzothiazolines. | Chiral cis-cyclopropanes are strained rigid analogues of alkyl chains, whose study and application are limited by their difficult synthesis. A modular approach from olefin materials is enabled by the discovery of the electron donor-acceptor (EDA) interaction between 2-substituted benzothiazolines and N-hydroxyphthalimi... | 10.1021/acscatal.1c03949 | 34,765,283 | ACS catalysis | 2,021 | ||
[A case of tuberous sclerosis presenting intractable adversive seizure, successfully resected with the technique of "gyrectomy"]. | We report a 9-year-old girl with tuberous sclerosis presenting intractable adversive seizure. She had been suffering from frequent attacks of consciousness loss since the age of 6 years. Although a considerable amount of antiepileptic drugs had been administered, her epileptic attacks were not controlled, but instead r... | 9,330,402 | D002540:Cerebral Cortex; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008722:Methods; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis | No shinkei geka. Neurological surgery | 1,997 | ||
A triple-step controller with linear active disturbance rejection control for a lower limb rehabilitation robot. | Lower limb rehabilitation robots (LLRRs) have shown promising potential in assisting hemiplegic patients to recover their motor function. During LLRR-aided rehabilitation, the dynamic uncertainties due to human-robot coupling, model uncertainties, and external disturbances, make it challenging to achieve high accuracy ... | 10.3389/fnbot.2022.1053360 | 36,506,820 | Frontiers in neurorobotics | 2,022 | ||
Alveolar bone loss and crowding in adult periodontal patients. | The present study aimed to examine whether local crowding and tooth angulation in the mandibular incisor region led to alveolar bone loss in patients with moderate periodontal disease. The sample comprised 27 patients from the Department of Periodontology aged 29-57 yr. Mesiodistal tooth angulation and crowding, define... | 10.1111/j.1600-0528.1989.tb01827.x | 2,917,458 | D000328:Adult; D001862:Bone Resorption; D005260:Female; D006801:Humans; D007571:Jaw Diseases; D008297:Male; D008310:Malocclusion; D008875:Middle Aged; D010510:Periodontal Diseases; D011859:Radiography | Community dentistry and oral epidemiology | 1,989 | |
In vitro and in vivo antagonism of actinomycetes isolated from Moroccan rhizospherical soils against Sclerotium rolfsii: a causal agent of root rot on sugar beet (Beta vulgaris L.). | AIMS
To evaluate the ability of the isolated actinomycetes to inhibit in vitro plant pathogenic fungi and the efficacy of promising antagonistic isolates to reduce in vivo the incidence of root rot induced by Sclerotium rolfsii on sugar beet.
METHODS AND RESULTS
Actinomycetes isolated from rhizosphere soil of sugar b... | 10.1111/j.1365-2672.2009.04232.x | 19,302,305 | D039903:Actinobacteria; D000898:Antibiosis; D001487:Basidiomycota; D027461:Beta vulgaris; D004271:DNA, Fungal; D025301:Hyphae; D010935:Plant Diseases; D012336:RNA, Ribosomal, 16S; D017422:Sequence Analysis, DNA; D012988:Soil Microbiology | Journal of applied microbiology | 2,009 | D004271:DNA, Fungal; D012336:RNA, Ribosomal, 16S |
Isotretinoin-loaded nanocapsules: stability and cutaneous penetration by tape stripping in human and pig skin. | The cutaneous penetration of isotretinoin-loaded poly(epsilon-caprolactone) nanocapsules (GEL-NCISO) was compared to that of free isotretinoin (GEL-FREE) incorporated in hydrogels by tape stripping in excised human and pig skin. The physicochemical stability of isotretinoin-loaded nanocapsules and a nanoemulsion (used ... | 10.1166/jbn.2012.1381 | 22,515,077 | D000269:Adhesives; D000818:Animals; D004355:Drug Stability; D005782:Gels; D006801:Humans; D015474:Isotretinoin; D008027:Light; D053769:Nanocapsules; D010782:Photolysis; D011091:Polyesters; D012542:Scattering, Radiation; D012867:Skin; D012869:Skin Absorption; D013552:Swine | Journal of biomedical nanotechnology | 2,012 | D000269:Adhesives; D005782:Gels; D053769:Nanocapsules; D011091:Polyesters; C016240:polycaprolactone; D015474:Isotretinoin |
Dynamic modulation of electronic properties of graphene by localized carbon doping using focused electron beam induced deposition. | We report on the first demonstration of controllable carbon doping of graphene to engineer local electronic properties of a graphene conduction channel using focused electron beam induced deposition (FEBID). Electrical measurements indicate that an "n-p-n" junction on graphene conduction channel is formed by partial ca... | 10.1039/c5nr04063a | 26,302,897 | Nanoscale | 2,015 | ||
Validation of an automated technique for quantification of pulmonary perfusion territories using computed tomography angiography. | Background
Computed tomography pulmonary angiography (CTPA) is the primary modality for the detection and diagnosis of pulmonary embolism (PE) while the stratification of PE severity remains challenging using angiography. Hence, an automated minimum-cost path (MCP) technique was validated to quantify the subtended lung... | 10.21037/qims-22-791 | 37,179,910 | Quantitative imaging in medicine and surgery | 2,023 | ||
Nerve growth factor decreases potassium currents and alters repetitive firing in rat sympathetic neurons. | The sympathetic nervous system is an essential regulator of the cardiovascular system and interactions with target tissue regulate sympathetic neuronal properties. The heart produces nerve growth factor (NGF), which promotes sympathetic noradrenergic innervation of cardiac tissue and affects sympathetic synaptic streng... | 10.1152/jn.01078.2005 | 16,707,716 | D000200:Action Potentials; D000818:Animals; D015220:Calcium Channels; D002478:Cells, Cultured; D003627:Data Interpretation, Statistical; D004558:Electric Stimulation; D004594:Electrophysiology; D006321:Heart; D015640:Ion Channel Gating; D009414:Nerve Growth Factors; D009431:Neural Conduction; D009474:Neurons; D018408:P... | Journal of neurophysiology | 2,006 | D015220:Calcium Channels; D009414:Nerve Growth Factors; D015221:Potassium Channels |
Apocalmodulin binds to the myosin light chain kinase calmodulin target site. | The interaction of a 20-residue-long peptide derived from the calmodulin-binding domain of the smooth muscle myosin light chain kinase with calcium-free calmodulin (apocalmodulin) was studied using a combination of isothermal titration calorimetry and differential scanning calorimetry. We showed that: (i) a significant... | 10.1074/jbc.274.26.18161 | 10,373,414 | D002118:Calcium; D002147:Calmodulin; D002152:Calorimetry, Differential Scanning; D002942:Circular Dichroism; D009219:Myosin-Light-Chain Kinase; D011485:Protein Binding; D011487:Protein Conformation; D013816:Thermodynamics | The Journal of biological chemistry | 1,999 | D002147:Calmodulin; D009219:Myosin-Light-Chain Kinase; D002118:Calcium |
Asymmetric hydrogenation of bicyclic ketones catalyzed by BINAP/IPHAN-Ru(II) complex. | Hydrogenation of 3-quinuclidinone and bicyclo[2.2.2]octan-2-one with a combined catalyst system of RuCl(2)[(S)-binap][(R)-iphan] and t-C(4)H(9)OK in 2-propanol afforded the chiral alcohols in 97-98% ee. 2-Diphenylmethyl-3-quinuclidinone was hydrogenated with the same catalyst to the cis alcohol with perfect diastereo- ... | 10.1021/ol101200z | 20,670,005 | Organic letters | 2,010 | ||
Studies using fluorescent tetrahydrochrysene estrogens for in situ visualization of the estrogen receptor in living cells. | We have analyzed four fluorescent nonsteroidal estrogens for their potential to serve as vital cytological stains to visualize the estrogen receptor (ER) in a model receptor expression system. The novel estrogen fluorophores are based on the rigidified stilbene-like structure of 5,6,11,12-tetrahydrochrysene (THC), and ... | 10.1210/mend.9.5.7565806 | 7,565,806 | D000818:Animals; D002478:Cells, Cultured; D002911:Chrysenes; D004967:Estrogens; D005456:Fluorescent Dyes; D006801:Humans; D008024:Ligands; D008856:Microscopy, Fluorescence; D009154:Mutation; D011960:Receptors, Estrogen; D013053:Spectrophotometry; D014162:Transfection | Molecular endocrinology (Baltimore, Md.) | 1,995 | D002911:Chrysenes; D004967:Estrogens; D005456:Fluorescent Dyes; D008024:Ligands; D011960:Receptors, Estrogen |
Effect of different selenium sources on productive performance, serum and milk Se concentrations, and antioxidant status of sows. | The experiment was conducted to study the effects of different selenium (Se) sources on productive performance, serum and milk Se concentrations, and antioxidant status of sows. A total of 12 sows (Landrace×Yorkshire) with same pregnancy were randomly divided into two groups; each group was replicated six times. These ... | 10.1007/s12011-010-8803-1 | 20,717,850 | D000818:Animals; D000975:Antioxidants; D003126:Colostrum; D005260:Female; D005978:Glutathione; D005979:Glutathione Peroxidase; D008892:Milk; D011247:Pregnancy; D011897:Random Allocation; D012098:Reproduction; D012643:Selenium; D012645:Selenomethionine; D018038:Sodium Selenite; D013482:Superoxide Dismutase; D013552:Swin... | Biological trace element research | 2,011 | D000975:Antioxidants; D012645:Selenomethionine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D012643:Selenium; D018038:Sodium Selenite |
Additional drug resistance of multidrug-resistant tuberculosis in patients in 9 countries. | Data from a large multicenter observational study of patients with multidrug-resistant tuberculosis (MDR TB) were analyzed to simulate the possible use of 2 new approaches to treatment of MDR TB: a short (9-month) regimen and a bedaquiline-containing regimen. Of 1,254 patients, 952 (75.9%) had no resistance to fluoroqu... | 10.3201/eid2106.141329 | 25,988,299 | D000995:Antitubercular Agents; D024901:Drug Resistance, Multiple, Bacterial; D054908:Extensively Drug-Resistant Tuberculosis; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis | Emerging infectious diseases | 2,015 | D000995:Antitubercular Agents |
Enhanced collision-induced decomposition efficiency and unraveling of fragmentation pathways for anionic adducts of brevetoxins in negative ion electrospray mass spectrometry. | Brevetoxins are a group of natural neurotoxins characterized by polyether ring systems that are found in the blooms of red tide algae. In a conventional water/organic solvent system, without any other additives, deprotonated molecules of brevetoxins do not appear in high abundance in negative mode electrospray mass spe... | 10.1021/ac901341c | 19,791,765 | D000838:Anions; D001639:Bicarbonates; D005459:Fluorides; D057097:Harmful Algal Bloom; D008387:Marine Toxins; D035964:Oxocins; D021241:Spectrometry, Mass, Electrospray Ionization | Analytical chemistry | 2,009 | D000838:Anions; D001639:Bicarbonates; D008387:Marine Toxins; D035964:Oxocins; C546611:brevetoxin 2; C546612:brevetoxin 3; C043466:brevetoxin B; D005459:Fluorides |
[Clinical picture and dynamics of mosaic variants of schizoid (autistic) psychopathy in childhood and adolescence]. | The clinical course of schizoepileptic and schizopsychoasthenic variants of developing schizoid psychopathy are reviewed. On the basis of the study of 45 patients in childhood and adolescence, specific characteristics of the psychopathic, pathocharacterologic and neurotic reactions are described and their role in the e... | 6,659,788 | D000293:Adolescent; D000987:Antisocial Personality Disorder; D002648:Child; D004827:Epilepsy; D006801:Humans; D008297:Male; D009440:Neurasthenia; D010551:Personality; D010553:Personality Development; D012557:Schizoid Personality Disorder; D013577:Syndrome | Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) | 1,983 | ||
Thin slice CT study of solitary pulmonary nodules with emphasis on the relation to vasculatures. | Thin (2 mm) and thick (10 mm) slice X-ray computed tomography (CT) scanning was performed in 49 and 31 patients, respectively, to assess the morphology of solitary pulmonary nodules or masses and to determine the relationship between the tumor and surrounding vasculature. When the pulmonary vein passed singly into the ... | 3,562,886 | D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery; D011667:Pulmonary Veins; D003074:Solitary Pulmonary Nodule; D014057:Tomography, X-Ray Computed | Radiation medicine | 1,986 | ||
Non-invasive localization of thymol accumulation in Carum copticum (Apiaceae) fruits by chemical shift selective magnetic resonance imaging. | Magnetic resonance imaging was used to localize the site of essential oil accumulation in fruit of Carum copticum L. (Apiaceae). A chemical shift method is described that utilized the spectral properties of the aromatic monoterpene thymol, the major component of the essential oil, to image thymol selectively. The prese... | 10.1093/aob/mcf179 | 12,197,523 | D029974:Carum; D005638:Fruit; D008401:Gas Chromatography-Mass Spectrometry; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D018613:Microscopy, Confocal; D009822:Oils, Volatile; D013943:Thymol | Annals of botany | 2,002 | D009822:Oils, Volatile; D013943:Thymol |
Effect of electronic media on children. | Radio, television (TV), movies, video games, cell phones, and computer networks have assumed central roles in our children's daily lives. The media has demonstrated potentially profound effects, both positive and negative, on children's cognitive, social, and behavioral development. Considering the increasing exposure ... | 10.1007/s13312-010-0128-9 | 20,683,108 | D000428:Alcohol Drinking; D002648:Child; D002652:Child Behavior; D001068:Feeding and Eating Disorders; D006801:Humans; D012725:Sexual Behavior; D012907:Smoking; D013690:Television | Indian pediatrics | 2,010 | |
The importance of age, sex and place in understanding socioeconomic inequalities in allostatic load: Evidence from the Scottish Health Survey (2008-2011). | BACKGROUND
Given the broad spectrum of health and wellbeing outcomes that are patterned by socioeconomic position (SEP), it has been suggested that there may be common biological pathways linking SEP and health. Allostatic load is one such pathway, which aims to measure cumulative burden/dysregulation across multiple p... | 10.1186/s12889-016-2796-4 | 26,856,976 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D052636:Allostasis; D015415:Biomarkers; D005260:Female; D054624:Health Status Disparities; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012606:Scotland; D012737:Sex Factors; D012959:Socioeconomic ... | BMC public health | 2,016 | D015415:Biomarkers |
A novel caspase dependent pathway is involved in apoptosis of human endothelial cells by Shiga toxins. | Shiga toxins have been shown to induce apoptosis on primary cultures, but not passaged ones, of human umbilical vein endothelial cells, independent of cytokine pre-treatment. Here, a peculiar pattern of caspase activation was observed; caspase-3 and -2, but not conventional upstream caspases, were activated at the init... | 10.1111/j.1348-0421.2002.tb02753.x | 12,477,248 | D000590:Amino Acid Chloromethyl Ketones; D017209:Apoptosis; D020126:Brefeldin A; D053143:Caspase 2; D053148:Caspase 3; D020169:Caspases; D015853:Cysteine Proteinase Inhibitors; D053938:DNA Fragmentation; D004730:Endothelium, Vascular; D004789:Enzyme Activation; D005434:Flow Cytometry; D006801:Humans; D011500:Protein Sy... | Microbiology and immunology | 2,002 | D000590:Amino Acid Chloromethyl Ketones; D015853:Cysteine Proteinase Inhibitors; D011500:Protein Synthesis Inhibitors; D022603:Shiga Toxins; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; D020126:Brefeldin A; C505407:CASP3 protein, human; D053143:Caspase 2; D053148:Caspase 3; D020169:Caspases |
Risk factors for acquisition of imipenem-resistant Acinetobacter baumannii: a case-control study. | Risk factors for the nosocomial occurrence of imipenem-resistant Acinetobacter baumannii (IRAB) were determined. A case-control study design was used for a comparison of two groups of A. baumannii-positive patients with control patients. Nosocomial IRAB was isolated from the first group of A. baumannii-positive patient... | 10.1128/AAC.48.1.224-228.2004 | 14,693,543 | D000151:Acinetobacter Infections; D040981:Acinetobacter baumannii; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002511:Cephalosporins; D003428:Cross Infection; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D015378:Imipenem; D007362:Intensive Care Units; D016015:Logistic Models; D008... | Antimicrobial agents and chemotherapy | 2,004 | D002511:Cephalosporins; D013845:Thienamycins; D015378:Imipenem |
[Molecular dynamics simulations of migration of ions and molecules through the acetylcholine receptor channel]. | A dynamic model of the channel of an acetylcholine receptor in a closed state has been proposed. The channel is formed by five a-helices of subunit M2 and stabilized by the cyclic hydrocarbon (CH2)105. The migration of charged and unchanged van der Waals particles with a diameter of 7.72 A equivalent to the diameter of... | 17,633,536 | D000595:Amino Acid Sequence; D000818:Animals; D017136:Ion Transport; D007477:Ions; D007700:Kinetics; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011950:Receptors, Cholinergic; D055672:Static Electricity | Biofizika | 2,007 | D007477:Ions; D011950:Receptors, Cholinergic | |
The evaluation of portal hypertension in cirrhotic patients with spectral computed tomography. | BACKGROUND
Iodine concentrations measured using dual-energy spectral CT (DESCT) have been recently proposed as providing good performance for examining tissues hemodynamics.
PURPOSE
To evaluate the diagnostic efficacy of DESCT-derived parameters in evaluating portal venous pressure in patients with liver cirrhosis.
... | 10.1177/02841851221101356 | 35,593,049 | D006801:Humans; D004932:Esophageal and Gastric Varices; D006975:Hypertension, Portal; D008103:Liver Cirrhosis; D014057:Tomography, X-Ray Computed; D007455:Iodine | Acta radiologica (Stockholm, Sweden : 1987) | 2,023 | D007455:Iodine |
Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer. | OBJECTIVE
We examined the association between body mass index (BMI) around the time of diagnosis, weight change post-diagnosis, and breast cancer prognosis in a prospective cohort study of 1,692 breast cancer survivors.
METHODS
Pre-diagnosis weight, weight at study entry, and height was obtained from mailed questionn... | 10.1007/s10552-008-9203-0 | 18,752,034 | D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001943:Breast Neoplasms; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009765:Obesity; D017698... | Cancer causes & control : CCC | 2,008 | |
Dominant negative mutations in yeast TFIID define a bipartite DNA-binding region. | Genetic analysis showed that the conserved C-terminal 180 amino acids of yeast TFIID contain all the essential functions for growth of yeast and response to acidic transcriptional activation signals. A genetic screen was used to identify functionally important residues within this C-terminal region. Five dominant TFIID... | 10.1016/0092-8674(91)90168-x | 2,015,629 | D000595:Amino Acid Sequence; D001665:Binding Sites; D015153:Blotting, Western; D004268:DNA-Binding Proteins; D005799:Genes, Dominant; D005800:Genes, Fungal; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D014176:Protein Biosynthesis; D011994:Recombinant Proteins; D012441:S... | Cell | 1,991 | D004268:DNA-Binding Proteins; D011994:Recombinant Proteins; D035362:Transcription Factor TFIID; D014157:Transcription Factors |
High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II. | Four focused libraries targeted for inhibition of the malarial proteases plasmepsin I and II were designed, synthesized, purified, and screened. Selected carboxylic acids and organometallic reactants with diverse physical properties were attached to the hydroxylethylamine scaffold in the P3 and P1' positions to furnish... | 10.1021/cc0301014 | 12,857,114 | D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001713:Biphenyl Compounds; D002264:Carboxylic Acids; D002402:Cathepsin D; D020650:Combinatorial Chemistry Techniques; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D019151:Peptide Library... | Journal of combinatorial chemistry | 2,003 | D001713:Biphenyl Compounds; D002264:Carboxylic Acids; D019151:Peptide Library; D011480:Protease Inhibitors; D015800:Protozoan Proteins; D011725:Pyridines; D016282:Aspartic Acid Endopeptidases; C089643:plasmepsin; C100637:plasmepsin II; D002402:Cathepsin D |
[Resection of nasopharyngeal mucoepidermoid carcinoma using the maxillary swing approach]. | Mucoepidermoid carcinomas (MECs) are a common neoplasm of the minor salivary glands. However, nasopharyngeal MECs are an extremely rare entity. We describe herein our experience in the resection of a nasopharyngeal MEC using the maxillary swing approach (MSA). A 42-year-old man was referred to our institute complaining... | 10.3950/jibiinkoka.116.1033 | 24,191,590 | D000328:Adult; D018277:Carcinoma, Mucoepidermoid; D006801:Humans; D008297:Male; D008437:Maxilla; D009303:Nasopharyngeal Neoplasms; D012470:Salivary Glands, Minor; D016896:Treatment Outcome | Nihon Jibiinkoka Gakkai kaiho | 2,013 | |
Effect of surfactants and inducers on increased uricase production under submerged fermentations by Bacillus cereus. | Uricase is a clinical enzyme used for the oxidation of uric acid crystals in gout disease. The present study aimed to increase the suitable surfactant-mediated uricase production on induction by different concentrations of inducers. The efficiency of Bacillus cereus to produce extracellular uricase enzyme was studied i... | 10.1080/10826068.2016.1168842 | 27,071,031 | D001409:Bacillus cereus; D004795:Enzyme Stability; D005285:Fermentation; D013501:Surface-Active Agents; D014503:Urate Oxidase | Preparative biochemistry & biotechnology | 2,017 | D013501:Surface-Active Agents; D014503:Urate Oxidase |
Corneal grafting of donor tissue preserved for longer than 4 weeks in organ-culture medium. | In vitro viability of the endothelium of corneas stored in organ-culture medium is longer than in other storage techniques. This article reports on the clinical results of 20 penetrating keratoplasties performed using corneas stored for > 4 weeks in organ culture. Seventeen of the procedures were elective and three wer... | 8,536,458 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002452:Cell Count; D003470:Culture Media; D004728:Endothelium, Corneal; D005260:Female; D006085:Graft Survival; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D009924:Organ Culture Techniques; D009926:Organ Preservation; D013997:Ti... | Cornea | 1,995 | D003470:Culture Media | |
Short-term efficacy and safety of vasopressin receptor antagonists for treatment of hyponatremia. | BACKGROUND
We performed a meta-analysis to systematically measure efficacy and safety of vasopressin receptor antagonists (VRAs) tested in randomized controlled trials for treatment of hyponatremia.
METHODS
MEDLINE, ClinicalTrials.gov, and scientific abstracts were searched without language restriction. Two authors i... | 10.1016/j.amjmed.2011.04.028 | 21,962,320 | D065092:Antidiuretic Hormone Receptor Antagonists; D006801:Humans; D007010:Hyponatremia; D016017:Odds Ratio; D012964:Sodium | The American journal of medicine | 2,011 | D065092:Antidiuretic Hormone Receptor Antagonists; D012964:Sodium |
Connectivity in Spanish metapopulation of Dupont's lark may be maintained by dispersal over medium-distance range and stepping stones. | BACKGROUND
Dupont's Lark is an endangered bird, whose fragmented distribution in Europe is entirely restricted to Spain. This lark, suffering pronounced population decline and range contraction, inhabits steppes that have long been used for grazing sheep and are now threatened by rural abandonment and land use changes.... | 10.7717/peerj.11925 | 34,466,286 | PeerJ | 2,021 | ||
An alternative hierarchical organization of the mental disorders of the DSM-IV. | With the approaching publication of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM), alternative organizations of the DSM (4th ed.; DSM-IV; American Psychiatric Association, 1994) categories have been proposed. This article compares several published alternative organizations to cli... | 10.1037/a0012535 | 18,729,621 | D000328:Adult; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders; D011361:Professional Competence; D012720:Severity of Illness Index | Journal of abnormal psychology | 2,008 | |
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. | Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger autoimmune diseases. Therefore, investigating the regulatory network that modulates Th17 differentiation may yield important therapeutic insights. miR-146a has emerged as a critical modulator of immune reactions, but its role in regulati... | 28,872,459 | D000818:Animals; D019898:Autocrine Communication; D015551:Autoimmunity; D002454:Cell Differentiation; D004681:Encephalomyelitis, Autoimmune, Experimental; D006801:Humans; D015850:Interleukin-6; D007378:Interleukins; D051379:Mice; D018345:Mice, Knockout; D035683:MicroRNAs; D009103:Multiple Sclerosis; D063308:Myelin-Olig... | The Journal of clinical investigation | 2,017 | D015850:Interleukin-6; D007378:Interleukins; D035683:MicroRNAs; C534190:Mirn146 microRNA, mouse; C571327:Mog protein, mouse; D063308:Myelin-Oligodendrocyte Glycoprotein; C577686:interleukin-6, mouse; C416243:interleukin-21 | |
NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels. | The solution structure of chlorotoxin, a small toxin purified from the venom of the Leiurus quinquestriatus scorpion, has been determined using 2D 1H NMR spectroscopy. Analysis of the NMR data shows that the structure consists of a small three-stranded antiparallel beta-sheet packed against an alpha-helix, thereby adop... | 10.1021/bi00001a003 | 7,819,188 | D000595:Amino Acid Sequence; D004220:Disulfides; D004563:Electrochemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009498:Neurotoxins; D017433:Protein Structure, Secondary; D012604:Scorpion Venoms; D017386:Sequence Homology, Amino Acid; D012996:Solutions; D0... | Biochemistry | 1,995 | D004220:Disulfides; D009498:Neurotoxins; D012604:Scorpion Venoms; D012996:Solutions; C091539:Chlorotoxin |
[Quality of life in men with arterial hypertension.] | OBJECTIVE
Systemic arterial hypertension is a Public Health problem, being the most important modifiable risk factor for morbidity and mortality, and the main single contributor to death and disability from all causes. Our objective was to estimate health-related quality of life using the MINICHAL questionnaire, to ide... | 34,483,337 | D006801:Humans; D006973:Hypertension; D008297:Male; D011788:Quality of Life; D012307:Risk Factors; D013030:Spain; D011795:Surveys and Questionnaires | Revista espanola de salud publica | 2,021 | ||
Nine-analyte detection using an array-based biosensor. | A fluorescence-based multianalyte immunosensor has been developed for simultaneous analysis of multiple samples. While the standard 6 x 6 format of the array sensor has been used to analyze six samples for six different analytes, this same format has the potential to allow a single sample to be tested for 36 different ... | 10.1021/ac0260185 | 12,498,211 | D000941:Antigens; D001419:Bacteria; D001426:Bacterial Proteins; D015374:Biosensing Techniques; D003429:Cross Reactions; D005453:Fluorescence; D007118:Immunoassay; D013997:Time Factors; D014118:Toxins, Biological | Analytical chemistry | 2,002 | D000941:Antigens; D001426:Bacterial Proteins; D014118:Toxins, Biological |
Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer. | Pancreatic ductal adenocarcinoma (PDAC) driven by oncogenic K-Ras remains among the most lethal human cancers despite recent advances in modern medicine. The pathogenesis of PDAC is partly attributable to intrinsic chromosome instability and extrinsic inflammation activation. However, the molecular link between these t... | 10.1038/cr.2017.51 | 28,374,746 | D000818:Animals; D063646:Carcinogenesis; D021441:Carcinoma, Pancreatic Ductal; D043171:Chromosomal Instability; D015331:Cohort Studies; D004249:DNA Damage; D011905:Genes, ras; D019695:Glycyrrhizic Acid; D024243:HMGB1 Protein; D006801:Humans; D015850:Interleukin-6; D053208:Kaplan-Meier Estimate; D051379:Mice; D008810:Mi... | Cell research | 2,017 | D024243:HMGB1 Protein; C585491:HMGB1 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D009707:Nucleosomes; D025521:Tumor Suppressor Proteins; D019695:Glycyrrhizic Acid |
The exon trapping assay partly discriminates against alternatively spliced exons. | A cosmid containing eight exons of the gene coding for the microtubule-associated tau protein was subjected to the exon trapping assay. All the constitutive exons contained in the cosmid (4, 5, 7 and 9) were efficiently captured regardless of size. Of the four alternatively spliced exons, three (3, 4A and 8) were not i... | 10.1093/nar/21.9.2217 | 7,684,835 | D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA; D005091:Exons; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012313:RNA | Nucleic acids research | 1,993 | D001426:Bacterial Proteins; C061910:tus protein, Bacteria; D012313:RNA; D004247:DNA |
Prediction of osteoporosis with dental radiographs and age. | OBJECTIVES
In this study age and the trabecular pattern present on dental radiographs were used to predict the presence of osteoporosis. The objective was to evaluate the contribution of the trabecular pattern to the prediction.
METHODS
In this project, 671 women between 45 and 71 years of age were recruited. Medical... | 10.1259/dmfr/55502190 | 19,767,512 | D015502:Absorptiometry, Photon; D000367:Age Factors; D000368:Aged; D015519:Bone Density; D016009:Chi-Square Distribution; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis; D011237:Predictive Value of Tests; D011861:Radiography, Dental; D012680:Sensitivity and Spec... | Dento maxillo facial radiology | 2,009 | |
Sex Comparison of Knee Extensor Size, Strength, and Fatigue Adaptation to Sprint Interval Training. | Bagley, L, Al-Shanti, N, Bradburn, S, Baig, O, Slevin, M, and McPhee, JS. Sex comparison of knee extensor size, strength, and fatigue adaptation to sprint interval training. J Strength Cond Res 35(1): 64-71, 2021-Regular sprint interval training (SIT) improves whole-body aerobic capacity and muscle oxidative potential,... | 10.1519/JSC.0000000000002496 | 29,533,360 | D000328:Adult; D005260:Female; D000072696:High-Intensity Interval Training; D006801:Humans; D007717:Knee; D007719:Knee Joint; D008297:Male; D018763:Muscle Fatigue; D053580:Muscle Strength; D018482:Muscle, Skeletal; D019415:Torque | Journal of strength and conditioning research | 2,021 | |
Innervation of the renal cortex. | Morphologic studies of renal innervation have utilized the methods of histochemistry and electron microscopy. Much information has been derived from examination of the renal cortex in monkey and rat. Fluorescence histochemistry shows a rich adrenergic innervation. Acetylcholinesterase can be demonstrated histochemicall... | 416,969 | D000110:Acetylcholinesterase; D000320:Adrenergic Fibers; D000818:Animals; D001160:Arterioles; D002395:Catecholamines; D000882:Haplorhini; D006892:Hydroxydopamines; D007672:Kidney Cortex; D007678:Kidney Glomerulus; D007684:Kidney Tubules; D008854:Microscopy, Electron; D009411:Nerve Endings; D051381:Rats | Federation proceedings | 1,978 | D002395:Catecholamines; D006892:Hydroxydopamines; D000110:Acetylcholinesterase | |
Efficacy of chest CT in a pediatric ICU: a prospective study. | STUDY OBJECTIVES
(1) To determine whether chest CT provides additional information compared with chest radiography regarding the nature of intrathoracic disease in critically ill children, (2) to determine whether such information alters clinical management, (3) to assess the role of a low-dose high-resolution CT (HRCT... | 10.1378/chest.117.6.1697 | 10,858,405 | D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011829:Radiation Dosage; D012140:Respiratory Tract Diseases; D014057:Tomography, X-Ray Computed | Chest | 2,000 | |
Friedreich's ataxia: preliminary results of some genealogical research. | A preliminary genealogical investigation of all the known ancestors from the year 1608 of 4 apparently unrelated French Canadian kindreds with Friedreich's ataxia reveals that the original ataxia gene in the province of Quebec was present within a core of no more than 10 families living in Quebec City in the mid-1600's... | 10.1017/s0317167100025488 | 1,000,413 | D003241:Consanguinity; D005260:Female; D005621:Friedreich Ataxia; D006801:Humans; D008297:Male; D010375:Pedigree; D011792:Quebec | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques | 1,976 | |
Efficacy and toxicity of concurrent chemoradiotherapy with nedaplatin and S-1 for head and neck cancer. | OBJECTIVE
We investigated the efficacy and toxicity of concurrent chemoradiotherapy with nedaplatin and S-1 for head and neck cancer, as an alternative to cisplatin and 5-fluorouracil.
METHODS
A total of 31 patients were enrolled in this study. S-1 was administered orally twice a day for 14 days followed by a 2-week ... | 10.1093/jjco/hyq196 | 21,109,512 | D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Age... | Japanese journal of clinical oncology | 2,011 | D004338:Drug Combinations; D009944:Organoplatinum Compounds; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; C053989:nedaplatin |
Robotic-assisted abdominal cerclage: a case report and literature review. | We report a robotic-assisted, ultrasound-guided abdominal cerclage placement during pregnancy that resulted in term delivery, and review the current literature with respect to the efficacy of robotic-assisted transabdominal cerclage (RoboTAC) placement. The patient was a 25-year-old gravida 5 para 0-0-4-0 with cervical... | 10.1007/s11701-014-0462-3 | 27,637,677 | Journal of robotic surgery | 2,014 | ||
Association between microbial characteristics and poor outcomes among patients with methicillin-resistant Staphylococcus aureus pneumonia: a retrospective cohort study. | BACKGROUND
Methicillin-resistant S. aureus (MRSA) pneumonia is associated with poor clinical outcomes. This study examined the association between microbial characteristics and poor outcomes among patients with methicillin-resistant Staphylococcus aureus pneumonia.
FINDINGS
This retrospective cohort study included 75... | 10.1186/s13756-015-0092-1 | 26,668,737 | Antimicrobial resistance and infection control | 2,015 | ||
Contamination Potentials of Household Water Handling and Storage Practices in Kirundo Subcounty, Kisoro District, Uganda. | Introduction
Waterborne diseases constitute a major public health burden in developing and underdeveloped countries. Consumption of contaminated water causes health risk to the public, and the situation is alarming in rural areas. The objective of this study was to assess the contamination potentials of different house... | 10.1155/2019/7932193 | 30,944,573 | D001419:Bacteria; D003430:Cross-Sectional Studies; D060766:Drinking Water; D006801:Humans; D012499:Sanitation; D014454:Uganda; D014871:Water Microbiology; D060753:Water Quality; D014881:Water Supply | Journal of environmental and public health | 2,019 | D060766:Drinking Water |
Annulation-Triggered Denitrogenative Transformations of 2-(5-Iodo-1,2,3-triazolyl)benzoic Acids. | The ability of [1,2,3]triazolobenzoxazinones to act as a source of "hidden" diazo group was discovered. These diazo precursors can be easily prepared by the intramolecular cyclization of 2-(5-iodo-1,2,3-triazolyl)benzoic acids. The Cu-catalyzed capture of the hidden diazo group allows for further functionalization thro... | 10.1021/acs.joc.2c00235 | 35,583,492 | The Journal of organic chemistry | 2,022 | ||
A Two-Step Strategy for the Rapid Enrichment of Nitrosocosmicus-Like Ammonia-Oxidizing Thaumarchaea. | Ammonia-oxidizing archaea (AOA) are widely distributed on the earth and play a significant role in the global nitrogen cycle. Although dozens of AOA strains were obtained in the last 13 years, it is still necessary to obtain more AOA strains for the entire exploration of their ecology, physiology, and underlying bioche... | 10.3389/fmicb.2019.00875 | 31,105,671 | Frontiers in microbiology | 2,019 | ||
The migration of blood-borne lymphocytes into rat popliteal lymph nodes stimulated with xenogeneic red blood cells. | The recruitment of radiolabelled blood-borne lymphocytes into rat popliteal lymph nodes (PLN) was investigated following the injection of varying doses of chicken (CRBC) or sheep red blood cells (SRBC) into the hind foot pad. Within the dose range tested (10(5)-10(8) RBC) an increase in the dose of injected antigen res... | 6,885,109 | D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D002465:Cell Movement; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes; D008198:Lymph Nodes; D008213:Lymphocyte Activation; D008214:Lymphocytes; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains | Immunology | 1,983 | D000941:Antigens | |
Genomic characterization of the NAC transcription factors, directed at understanding their functions involved in endocarp lignification of iron walnut (Juglans sigillata Dode). | The NAC (NAM, ATAF1/2, and CUC2) transcription factors (TF), one of the largest plant-specific gene families, play important roles in the regulation of plant growth and development, stress response and disease resistance. In particular, several NAC TFs have been identified as master regulators of secondary cell wall (S... | 10.3389/fgene.2023.1168142 | 37,229,193 | Frontiers in genetics | 2,023 | ||
The modified rhomboid transposition flap in periocular reconstruction. | The traditional rhomboid transposition flap has been widely used in reconstructive surgery. The authors have modified the original technique by eliminating the creation of the rhomboid defect and by directly transposing the flap into the original postexcisional defect. These changes allow maximum flexibility in flap de... | 10.1097/00002341-199809000-00011 | 9,783,289 | D019882:Blepharoplasty; D002280:Carcinoma, Basal Cell; D005142:Eyelid Neoplasms; D005143:Eyelids; D006801:Humans; D012189:Retrospective Studies; D013524:Surgical Flaps | Ophthalmic plastic and reconstructive surgery | 1,998 | |
Treatment for intermediate and high-risk prostate cancer: controversial issues and the role of hyperthermia. | For patients affected by intermediate- and high-risk prostate cancer, a single local therapy is not enough, and a more aggressive treatment, such as androgen suppression therapy (AST) and pelvic irradiation, is indicated. Biochemical disease-free survival (bDFS) and overall survival (OS) improve in intermediate- and hi... | 10.3109/02656736.2010.509749 | 21,043,571 | D000726:Androgen Antagonists; D017326:Clinical Trials, Phase III as Topic; D018572:Disease-Free Survival; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D011471:Prostatic Neoplasms; D011788:Quality of Life; D011878:Radiotherapy; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016896:... | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | 2,010 | D000726:Androgen Antagonists |
Ventricular pressure-volume area (PVA) accounts for cardiac energy consumption of work production and absorption. | We briefly review that ventricular systolic pressure-volume area (PVA) can predict changes in myocardial O2 consumption (VO2) associated with cardiac work production (positive work) and absorption (negative work). PVA represents the total mechanical energy of cardiac contraction as it is an integral of mechanical energ... | 10.1007/978-1-4684-6039-1_54 | 9,889,861 | D000818:Animals; D001696:Biomechanical Phenomena; D004285:Dogs; D006801:Humans; D009200:Myocardial Contraction; D016276:Ventricular Function | Advances in experimental medicine and biology | 1,998 | |
IMVAMUNE: modified vaccinia Ankara strain as an attenuated smallpox vaccine. | Smallpox vaccines based on replicating vaccinia virus are known to elicit rare yet serious adverse events, particularly in human populations with immune deficiency, atopic dermatitis and at the extremes of age. A vaccine that induces protective immune responses equivalent to first-generation smallpox vaccines while red... | 10.1586/14760584.8.1.13 | 19,093,767 | D002986:Clinical Trials as Topic; D006801:Humans; D012900:Smallpox Vaccine; D014613:Vaccines, Attenuated | Expert review of vaccines | 2,009 | D012900:Smallpox Vaccine; D014613:Vaccines, Attenuated; C527606:smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic |
The use of prophylactic penicillin in periodontal surgery. | In an attempt to prevent postoperative sequellae dentists often prescribe penicillin or other antibiotics following periodontal surgery. A review of the literature shows conflicting reports about this procedure. This study investigated the efficacy of prophylactic penicillin in 19 human subjects undergoing periodontal ... | 10.1902/jop.1980.51.1.44 | 6,767,012 | D003773:Dental Plaque; D004311:Double-Blind Method; D005883:Gingival Crevicular Fluid; D005891:Gingivitis; D006801:Humans; D010149:Pain, Postoperative; D010404:Penicillin V; D010510:Periodontal Diseases; D010512:Periodontal Index; D010919:Placebos | Journal of periodontology | 1,980 | D010919:Placebos; D010404:Penicillin V |
Evaluation of chemical flame retardants for carcinogenic potential. | Tetrakis(hydroxymethyl)phosphonium chloride (THPC) and Pyroset TKP, which is the mixed acetate/phosphate of the same phosphonium base, are widely used in flame-retardant cotton fabrics, particularly in children's sleepwear. THPC degrades thermally and under certain chemical conditions to yield hydrochloric acid and for... | 10.1080/15287397709529454 | 846,002 | D000818:Animals; D001725:Bis(Chloromethyl) Ether; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D003020:Clothing; D005260:Female; D000432:Methanol; D051379:Mice; D008813:Mice, Inbred ICR; D009943:Organophosphorus Compounds; D012878:Skin Neoplasms; D013997:Time Factors | Journal of toxicology and environmental health | 1,977 | D002273:Carcinogens; D009943:Organophosphorus Compounds; C014850:tetramethylolphosphonium chloride; C014787:Pyroset TKP; D001725:Bis(Chloromethyl) Ether; D000432:Methanol |
Strategic use of evidence during police interviews: when training to detect deception works. | Research on deception detection in legal contexts has neglected the question of how the use of evidence can affect deception detection accuracy. In this study, police trainees (N=82) either were or were not trained in strategically using the evidence when interviewing lying or truth telling mock suspects (N=82). The tr... | 10.1007/s10979-006-9053-9 | 16,977,348 | D000328:Adult; D003463:Cues; D008192:Deception; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008014:Lie Detection; D008297:Male; D016495:Police; D011795:Surveys and Questionnaires; D013663:Teaching | Law and human behavior | 2,006 | |
Why we disagree to disagree: a reply to commentaries by Robertson and McGilly, and Lindsay. | In this contribution the authors reply to two commentaries - published in this issue - on their earlier paper discussing the changing attitudes towards the care of children in hospital in the UK between 1940 and 1970. They argue that the work of Robertson and Bowlby was indeed very important in bringing about these cha... | 10.1080/14616730903282522 | 20,183,558 | D001294:Attitude to Health; D002648:Child; D002662:Child Health Services; D049673:History, 20th Century; D006776:Hospitals, Pediatric; D006801:Humans; D011369:Professional-Patient Relations | Attachment & human development | 2,009 | |
Intracavity hyperthermia in nasopharyngeal cancer: a phase III clinical study. | PURPOSE
To compare the local tumour control, survival, and acute mucous toxicity of nasopharyngeal cancer (NPC) patients treated with conventional radiotherapy (RT) combined with intracavity hyperthermia versus conventional RT alone.
METHODS AND MATERIALS
Previously untreated NPC patients were assigned randomly into ... | 10.3109/02656736.2010.503982 | 20,858,104 | D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D009303:Nasopharyngeal Neoplasms; D012074:Remission Induction; D016896:Treatment Outcome | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | 2,011 | |
Extended use of the intrauterine device: a literature review and recommendations for clinical practice. | There are multiple advantages to "extended use" of the intrauterine device (IUD) use beyond the manufacturer-approved time period, including prolongation of contraceptive and non-contraceptive benefits. We performed a literature review of studies that have reported pregnancy outcomes associated with extended use of IUD... | 24,679,478 | D000367:Age Factors; D019317:Evidence-Based Medicine; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D007434:Intrauterine Devices; D007435:Intrauterine Devices, Copper; D007436:Intrauterine Devices, Medicated; D010353:Patient Education as Topic; D017410:Practice Guidelines as Topic; D057285:Precision Medi... | Contraception | 2,014 | ||
Elevated plasma levels of S-100b protein in schizophrenic patients. | BACKGROUND
In this study, we examined the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia.
METHODS
We compared plasma levels of S-100b protein in 20 patients with schizophrenic psychosis and 20 age- and gender-matched healthy blood donors. Concentrations of S-100 p... | 10.1016/s0006-3223(98)00217-0 | 10,356,634 | D000328:Adult; D015415:Biomarkers; D001921:Brain; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D012559:Schizophrenia | Biological psychiatry | 1,999 | D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins |
The TMA-93: A New Memory Test for Alzheimer's Disease in Illiterate and Less Educated People. | The present study aimed at validating the Memory Associative Test of the district of Seine-Saint-Denis (TMA)-93, a new test of episodic memory. The TMA-93 was proposed to mostly less educated and multicultural elderly population composed of 376 healthy controls (HC) and 94 patients with Alzheimer's disease (AD). The co... | 10.1177/1533317517722630 | 28,750,554 | D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease; D004522:Educational Status; D005260:Female; D005602:France; D006801:Humans; D000067010:Literacy; D008297:Male; D061212:Memory, Episodic; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D015203:Reproducibility of Results; D... | American journal of Alzheimer's disease and other dementias | 2,017 | |
Liver transplantation in man: morphometric analysis of the parenchymal alterations following cold ischaemia and warm ischaemia/reperfusion. | Ischaemia and reperfusion phases represent critical events during liver transplantation. The purpose of this study was to describe morphological alterations of both vascular and parenchymal compartments after ischaemia and reperfusion and to evaluate the possible relationship between morphometric parameters and biochem... | 10.1046/j.1469-7580.2001.19850603.x | 11,430,699 | D000328:Adult; D000704:Analysis of Variance; D002452:Cell Count; D002467:Cell Nucleus; D003593:Cytoplasm; D005260:Female; D022781:Hepatocytes; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver; D008107:Liver Diseases; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D015427:Rep... | Journal of anatomy | 2,001 | |
Liver Fibrosis Evaluation Using Real-time Shear Wave Elastography in Hepatitis C-Monoinfected and Human Immunodeficiency Virus/Hepatitis C-Coinfected Patients. | OBJECTIVES
A few studies have evaluated real-time shear wave elastography (SWE) for assessing liver fibrosis by measuring liver stiffness in patients with chronic hepatitis C virus (HCV) infection, but they excluded human immunodeficiency virus/HCV-coinfected patients. We investigated the diagnostic performance of live... | 10.7863/ultra.15.08066 | 27,151,906 | D000328:Adult; D019540:Area Under Curve; D060085:Coinfection; D054459:Elasticity Imaging Techniques; D005260:Female; D015658:HIV Infections; D006526:Hepatitis C; D006801:Humans; D008099:Liver; D008103:Liver Cirrhosis; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity a... | Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine | 2,016 | |
Production of high level of cellulase-poor xylanases by wild strains of white-rot fungus Coprinellus disseminatus in solid-state fermentation. | The production, optimisation and partial characterisation of xylanases from newly isolated wild strains of Coprinellus disseminatus was performed in solid-state fermentation. Strains SH-1 and SH-2 showed high xylanase (727.78 and 227.99 IU/mL) with very low CMCase (0.925 and 0.660 IU/mL) and laccase (0.640 and 0.742 U/... | 10.1016/j.nbt.2009.09.004 | 19,761,879 | D001487:Basidiomycota; D001709:Biotechnology; D002480:Cellulase; D004591:Electrophoresis, Polyacrylamide Gel; D043364:Endo-1,4-beta Xylanases; D005285:Fermentation; D005656:Fungal Proteins; D005947:Glucose; D006863:Hydrogen-Ion Concentration; D007785:Lactose; D008031:Lignin; D009584:Nitrogen; D013347:Subcellular Fracti... | New biotechnology | 2,009 | D005656:Fungal Proteins; C036909:lignocellulose; D008031:Lignin; D002480:Cellulase; D043364:Endo-1,4-beta Xylanases; D005947:Glucose; D007785:Lactose; D009584:Nitrogen |
An overview of selected state licensure athletic training laws. | With the growth of athletic training, many state governing bodies have created regulations concerning the role of athletic trainers in their respective states. Some of these states have included the licensure, certification, and/or registration of athletic trainers as a prerequisite for employment. Although many states... | 16,558,149 | Journal of athletic training | 1,992 | |||
HBV serological markers of vaccinated children in remote areas of Taiwan: emphasis on factors contributing to vaccine failure. | A serosurvey targeting Hepatitis B virus (HBV)-vaccinated children born between 1986 and 1998 was conducted in 2001 in remote Taiwanese villages where a 1993 serosurvey indicated high vaccine failure. The HBV S antigen (HBsAg) seropositive rate among vaccinees of 3-6-year-old children in 2001 was significantly lower th... | 10.1016/j.vaccine.2007.06.022 | 17,629,600 | D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D006515:Hepatitis B virus; D006801:Humans; D008297:Male; D015999:Multivariate Analys... | Vaccine | 2,007 | D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines |
The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes. | We hypothesized that rho/rho kinase plays a role in sex differences in vascular dysfunction of diabetics. Contractions to serotonin were greater in isolated aortic rings from nondiabetic males versus females and increased further in streptozotocin-induced diabetic males but not females. The increased contractions to se... | 10.1155/2010/176361 | 20,368,772 | D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000818:Animals; D003921:Diabetes Mellitus, Experimental; D003922:Diabetes Mellitus, Type 1; D003925:Diabetic Angiopathies; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012727:Sex Characteristics; D013311:Streptozocin; D014661:Vasoconst... | Experimental diabetes research | 2,010 | D013311:Streptozocin; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D054460:rho-Associated Kinases; D020742:rhoA GTP-Binding Protein; C049347:fasudil |
The Efficacy of GnRHa Alone or in Combination with rhGH for the Treatment of Chinese Children with Central Precocious Puberty. | The addition of recombinant human growth hormone (rhGH) to GnRH agonist (GnRHa) to treat central precocious puberty (CPP) is controversial. We systemically reviewed and evaluated the efficacy and safety of the rhGH and GnRHa adjunctive therapy in Chinese children with CPP and assessed the influence of age and therapy d... | 10.1038/srep24259 | 27,072,597 | D002648:Child; D002681:China; D002986:Clinical Trials as Topic; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D019382:Human Growth Hormone; D006801:Humans; D008297:Male; D011629:Puberty, Precocious; D011994:Recombinant Proteins | Scientific reports | 2,016 | D011994:Recombinant Proteins; D019382:Human Growth Hormone; D007987:Gonadotropin-Releasing Hormone |
Microsurgical vs. Endoscopic Excision of Colloid Cysts: An Analysis of Complications and Costs Using a Longitudinal Administrative Database. | OBJECTIVE
Open microsurgical and endoscopic approaches are the two main surgical options for excision of colloid cysts. Controversy remains as to which is superior. Previous studies consist of small cohort sizes. This topic has not been investigated using national administrative claims data which benefits from larger p... | 10.3389/fneur.2017.00259 | 28,649,225 | Frontiers in neurology | 2,017 | ||
[Intraoperative radiotherapy during plastic surgery for lung cancer]. | The results of 28 bronchoplastic operations for non-small cell lung cancer and 3-8 year follow-up have been evaluated. Intraoperative radiotherapy (IORT) (10 Gy) was conducted in 6 patients. IORT was used as a component of combined treatment with good results and without postoperative complications. | 10,853,424 | D000328:Adult; D001984:Bronchial Neoplasms; D002289:Carcinoma, Non-Small-Cell Lung; D005500:Follow-Up Studies; D006801:Humans; D007432:Intraoperative Period; D008175:Lung Neoplasms; D008875:Middle Aged; D011878:Radiotherapy; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome | Voprosy onkologii | 2,000 | ||
Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection? | Acid-sensing ion channels (ASIC) are voltage-independent cationic channels that open in response to decrease in extracellular pH. Amongst different subtypes, ASIC3 has received much attention in joint inflammatory conditions including rheumatoid arthritis. There have been a number of studies showing that there is an in... | 10.1080/08923973.2018.1485156 | 30,035,658 | D062565:Acid Sensing Ion Channels; D000818:Animals; D001172:Arthritis, Rheumatoid; D005786:Gene Expression Regulation; D055785:Gene Knockdown Techniques; D006801:Humans; D007249:Inflammation; D009475:Neurons, Afferent; D010146:Pain | Immunopharmacology and immunotoxicology | 2,018 | C112231:ASIC3 protein, human; D062565:Acid Sensing Ion Channels |
Swimming as Treatment of Scapular Dyskinesis. | Scapular dyskinesis is quite frequent and can lead to shoulder pain. The diagnosis is essentially clinical. The main cause is muscle imbalance, between the trapezius, rhomboids, and pectoralis minor. In these cases, rehabilitation is the best treatment. We present a case of a young male patient with dyskinesis due to a... | 10.1155/2019/5607970 | 30,805,236 | Case reports in orthopedics | 2,019 | ||
Asynchronous Multiplex Communication Channels in 2-D Neural Network With Fluctuating Characteristics. | Neurons behave like transistors, but have fluctuating characteristics. In this paper, we show that several asynchronous multiplex communication channels can be established in a 2-D mesh neural network with randomly generated weights between eight neighbors. Neurons were simulated by integrate-and-fire neuron models wit... | 10.1109/TNNLS.2018.2880565 | 30,571,647 | D000200:Action Potentials; D001921:Brain; D003142:Communication; D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D016571:Neural Networks, Computer; D009474:Neurons | IEEE transactions on neural networks and learning systems | 2,019 | |
Granulocyte elastase-mediated proteolysis of alpha 1-antitrypsin in cystic fibrosis bronchopulmonary secretions. | Airway secretions of patients with cystic fibrosis (CF) contain large amounts of alpha 1-antitrypsin (alpha 1-AT), yet elastase activity is also often detectable, suggesting that airway alpha 1-AT may not be functional in some CF patients. It is unknown whether in CF sputum alpha 1-AT is inactivated by oxidants, neutro... | 10.1002/ppul.1950070105 | 2,788,857 | D000293:Adolescent; D000818:Animals; D001980:Bronchi; D003550:Cystic Fibrosis; D006098:Granulocytes; D006801:Humans; D010196:Pancreatic Elastase; D013183:Sputum; D000515:alpha 1-Antitrypsin | Pediatric pulmonology | 1,989 | D000515:alpha 1-Antitrypsin; D010196:Pancreatic Elastase |
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