title large_stringlengths 0 979 | abstract large_stringlengths 1 94.7k | doi large_stringlengths 0 71 | pmid int64 21 38.1M | mesh_terms large_stringlengths 0 1.47k | journal large_stringlengths 1 239 | pubdate int16 1.97k 2.02k | chemical_list large_stringlengths 0 1.47k |
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NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties. | We compared the lipid-lowering, vasodilating, anti-thrombotic and anti-inflammatory properties of NCX 6560, a novel NO-releasing derivative of atorvastatin, with those of atorvastatin. NCX 6560 and atorvastatin induced similar inhibition of cholesterol biosynthesis in rat smooth muscle cells (IC(50)=1.9+/-0.4 and 3.9+/... | 10.1016/j.ejphar.2007.05.014 | 17,632,098 | D000818:Animals; D000893:Anti-Inflammatory Agents; D000924:Anticholesteremic Agents; D001013:Aorta, Thoracic; D000069059:Atorvastatin; D001794:Blood Pressure; D002460:Cell Line; D002784:Cholesterol; D006152:Cyclic GMP; D005343:Fibrinolytic Agents; D006538:Heptanoic Acids; D006949:Hyperlipidemias; D066298:In Vitro Techn... | European journal of pharmacology | 2,007 | D000893:Anti-Inflammatory Agents; D000924:Anticholesteremic Agents; D005343:Fibrinolytic Agents; D006538:Heptanoic Acids; C524539:NCX 6560; D020030:Nitric Oxide Donors; D009573:Nitrites; D011758:Pyrroles; D014409:Tumor Necrosis Factor-alpha; D014665:Vasodilator Agents; D002784:Cholesterol; D000069059:Atorvastatin; D052... |
The FAA's postmortem forensic toxicology self-evaluated proficiency test program: the second seven years. | During toxicological evaluations of samples from fatally injured pilots involved in civil aviation accidents, a high degree of quality control/quality assurance (QC/QA) is maintained. Under this philosophy, the Federal Aviation Administration (FAA) started a forensic toxicology proficiency-testing (PT) program in July ... | 10.1093/jat/33.4.229 | 19,470,227 | D000060:Accidents, Aviation; D000068:Accreditation; D000818:Animals; D001344:Autopsy; D001359:Aviation; D001774:Blood Chemical Analysis; D053593:Forensic Toxicology; D006077:Government Agencies; D006801:Humans; D015397:Program Evaluation; D011786:Quality Control; D015203:Reproducibility of Results; D015813:Substance Ab... | Journal of analytical toxicology | 2,009 | |
Synthesis of oligosaccharide fragments of the repeating unit of Salmonella kentucky O-specific polysaccharide and conversion of the oligosaccharides into the glycosyl phosphates. | alpha-D-Man-(1----2)-alpha-D-Man-(1----3)-D-Gal, a structural fragment of the main chain of Salmonella serogroups C2 and C3 O-specific polysaccharides, and the isomer with the central residue beta have been synthesised, as have some oligosaccharides related to the structure of the O-specific polysaccharide of S. kentuc... | 10.1016/0008-6215(87)84009-0 | 3,568,001 | D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009844:Oligosaccharides; D010710:Phosphates; D011135:Polysaccharides, Bacterial; D012475:Salmonella | Carbohydrate research | 1,987 | D007202:Indicators and Reagents; D009844:Oligosaccharides; D010710:Phosphates; D011135:Polysaccharides, Bacterial |
The Primacy of Discourse in the Study of Gender in Family Therapy. | Family therapists and scholars increasingly adopt poststructural and postmodern conceptions of social reality, challenging the notion of stable, universal dynamics within family members and families and favoring a view of reality as produced through social interaction. In the study of gender and diversity, many envisio... | 10.1111/famp.12294 | 28,488,264 | D003142:Communication; D005190:Family; D005196:Family Therapy; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D011209:Power, Psychological; D063507:Sexism | Family process | 2,017 | |
Alpha helical crossovers favor right-handed supersecondary structures by kinetic trapping: the phone cord effect in protein folding. | The remarkable predominance of right-handedness in beta-alpha-beta helical crossovers has been previously explained in terms of thermodynamic stability and kinetic accessibility, but a different kinetic trapping mechanism may also play a role. If the beta-sheet contacts are made before the crossover helix is fully form... | 10.1002/pro.182 | 19,569,186 | D003198:Computer Simulation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D013816:Thermodynamics | Protein science : a publication of the Protein Society | 2,009 | |
Modulatory effect of opioid ligands on status epilepticus and the role of nitric oxide pathway. | Epilepsy is a chronic disorder that causes unprovoked, recurrent seizures. Status epilepticus (SE) is a medical emergency associated with significant morbidity and mortality. Morphine has been the cornerstone of pain controlling medicines for a long time. In addition to the analgesic and opioid responses, morphine has ... | 10.1016/j.yebeh.2019.106563 | 31,675,604 | D000701:Analgesics, Opioid; D000818:Animals; D000927:Anticonvulsants; D004305:Dose-Response Relationship, Drug; D007191:Indazoles; D008024:Ligands; D018021:Lithium Chloride; D008297:Male; D009020:Morphine; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D010433:Pentylenetetra... | Epilepsy & behavior : E&B | 2,019 | D000701:Analgesics, Opioid; D000927:Anticonvulsants; D007191:Indazoles; D008024:Ligands; D010862:Pilocarpine; D009569:Nitric Oxide; D009020:Morphine; D019001:Nitric Oxide Synthase; D018021:Lithium Chloride; C080122:7-nitroindazole; D019331:NG-Nitroarginine Methyl Ester; D010433:Pentylenetetrazole |
Oxygenation of organosulfur compounds by peroxidases: evidence of an electron transfer mechanism for lactoperoxidase. | The oxygenation of benzyl methylsulfide, thioanisole, and thiobenzamide to the respective sulfoxides was found to be catalyzed by chloroperoxidase, lactoperoxidase, and horseradish peroxidase. The activities of lactoperoxidase and horseradish peroxidase were similarly low toward benzyl methylsulfide and thioanisole but... | 10.1016/0003-9861(86)90636-3 | 3,947,087 | D002711:Chloride Peroxidase; D003577:Cytochrome P-450 Enzyme System; D004579:Electron Transport; D006735:Horseradish Peroxidase; D007700:Kinetics; D007784:Lactoperoxidase; D010084:Oxidation-Reduction; D010100:Oxygen; D010544:Peroxidases; D013440:Sulfides; D013454:Sulfoxides; D013455:Sulfur; D013854:Thioamides | Archives of biochemistry and biophysics | 1,986 | D013440:Sulfides; D013454:Sulfoxides; D013854:Thioamides; D013455:Sulfur; C015539:thiobenzamide; D003577:Cytochrome P-450 Enzyme System; D006735:Horseradish Peroxidase; D007784:Lactoperoxidase; D010544:Peroxidases; D002711:Chloride Peroxidase; D010100:Oxygen |
Comparative evaluation of fluorescence polarization assay and competitive ELISA for the diagnosis of bovine brucellosis vis-a-vis sero-monitoring. | Brucellosis is an important zoonosis that constitutes a serious public health hazard which is caused by a bacterium belonging to the genus Brucella. In the present study, two highly specific serological tests for brucellosis diagnosis, fluorescence polarization assay (FPA) and competitive ELISA (cELISA) were standardiz... | 10.1016/j.mimet.2020.105858 | 32,014,437 | D000818:Animals; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D002003:Brucella abortus; D002007:Brucellosis, Bovine; D002417:Cattle; D004797:Enzyme-Linked Immunosorbent Assay; D016231:Fluorescence Polarization Immunoassay; D008403:Mass Screening; D012680:Sensitivity and Specificity; D012698:Serologic Test... | Journal of microbiological methods | 2,020 | D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines |
Glycodelin suppresses endometrial cell migration and invasion but stimulates spheroid attachment. | Glycodelin contains four isoforms with diverse biological functions. Glycodelin-A is potentially a diagnostic marker for cancer patients and receptivity marker of the secretory endometrium. Yet, direct evidence for the role of glycodelin in the regulation of endometrial epithelial cell migration, invasion and attachmen... | 10.1016/j.rbmo.2012.03.004 | 22,503,278 | D018269:Carcinoma, Endometrioid; D002453:Cell Cycle; D002460:Cell Line; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D002470:Cell Survival; D010064:Embryo Implantation; D016889:Endometrial Neoplasms; D004717:Endometrium; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins; D0068... | Reproductive biomedicine online | 2,012 | D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins |
A feasibility study on pellet coating using a high-speed quasi-continuous coater. | Pellet coating is traditionally carried out using the Wurster coater. This study investigated the feasibility of pellet coating in a newly developed coater built with a unique airflow system, the Supercell™ coater (GEA Pharma Systems, UK). A full factorial design study was carried out to evaluate the influences of the ... | 10.1208/s12249-012-9852-x | 22,996,671 | D000388:Air; D003116:Color; D004343:Drug Implants; D005240:Feasibility Studies; D010316:Particle Size; D011312:Pressure; D013608:Tablets, Enteric-Coated; D013678:Technology, Pharmaceutical; D013816:Thermodynamics | AAPS PharmSciTech | 2,012 | D004343:Drug Implants; D013608:Tablets, Enteric-Coated |
Grading contact lens-related microbial keratitis: relevance to disease burden. | PURPOSE
To describe a clinical grading system for epidemiological investigation of presumed contact lens related microbial keratitis (MK) and investigate the relationship to associated costs and disease duration.
METHODS
Eligible cases identified via surveillance required positive culture or presence of at least one ... | 10.1097/OPX.0b013e31817dba2e | 18,594,345 | D000293:Adolescent; D000328:Adult; D001315:Australia; D003261:Contact Lenses; D003320:Corneal Ulcer; D017281:Cost of Illness; D015818:Eye Infections, Bacterial; D005260:Female; D006302:Health Services Research; D006801:Humans; D008297:Male; D008875:Middle Aged; D009520:New Zealand; D012720:Severity of Illness Index | Optometry and vision science : official publication of the American Academy of Optometry | 2,008 | |
Source, Spatial Distribution and Pollution Assessment of Pb, Zn, Cu, and Pb, Isotopes in urban soils of Ahvaz City, a semi-arid metropolis in southwest Iran. | This study examined the status of toxic metal contamination of the urban industrial city of Ahvaz in Iran. Two hundred and twenty-seven surface soils from a depth horizon of 0-10 cm were collected from urban areas. In addition, 15 soil samples were collected to recognise the sources of Pb in urban topsoils in Ahvaz cit... | 10.1038/s41598-019-41787-w | 30,926,876 | Scientific reports | 2,019 | ||
Molecular mechanism controlling anthocyanin composition and content in radish plants with different root colors. | Radish (Raphanus sativus) roots exhibit various colors that reflect their anthocyanin compositions and contents. However, the details of the mechanism linking the expression of anthocyanin biosynthesis and their transcriptional regulators to anthocyanin composition in radish roots remained unknown. Here, we characteriz... | 10.1016/j.plaphy.2023.108091 | 37,864,927 | D031224:Raphanus; D000872:Anthocyanins; D010940:Plant Proteins; D014157:Transcription Factors; D051792:Basic Helix-Loop-Helix Transcription Factors; D018506:Gene Expression Regulation, Plant | Plant physiology and biochemistry : PPB | 2,023 | D000872:Anthocyanins; D010940:Plant Proteins; D014157:Transcription Factors; D051792:Basic Helix-Loop-Helix Transcription Factors |
Attachment and separateness. A dialectic model of the products and processes of development throughout the life cycle. | Various theories of psychological development can be characterized according to whether they are primarily separation or attachment theories and whether they emphasize primarily the processes or the products of development. A full understanding of psychological development requires an integration of theories of attachm... | 2,251,302 | D006801:Humans; D007207:Individuation; D009769:Object Attachment; D010553:Personality Development; D011574:Psychoanalytic Theory | The Psychoanalytic study of the child | 1,990 | ||
Robust half-metallicity and topological aspects in two-dimensional Cu-TPyB. | Half-metallicity due to the coexistence of metallic nature for one spin component and insulating nature for the other is a base of spintronics devices, but was only achieved in few materials. From first-principles calculations, we demonstrate that a recently-synthesized two-dimensional organometallic framework of 1,3,5... | 10.1038/srep14098 | 26,365,292 | Scientific reports | 2,015 | ||
[Reproductive rights of women and men in light of new legislation on voluntary sterilization in Brazil]. | This paper aims to analyze the impacts and possible changes that the implementation of a new Brazilian family planning law has on reproductive practices, especially voluntary sterilization, and to determine whether men's and women's reproductive rights are being respected. The methodological approach is based on a six-... | 10.1590/s0102-311x2003000800025 | 15,029,363 | D001938:Brazil; D016656:Family Planning Policy; D005193:Family Planning Services; D005260:Female; D006301:Health Services Needs and Demand; D006806:Human Rights; D006801:Humans; D008297:Male; D012098:Reproduction; D017678:Sex Distribution; D012959:Socioeconomic Factors; D013245:Sterilization, Reproductive; D013246:Ster... | Cadernos de saude publica | 2,003 | |
Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging. | Ischemic heart disease (IHD) is the leading cause of death, with age range being the primary factor for development. The mechanisms by which aging increases vulnerability to ischemic insult are not well understood. We aim to use single-cell RNA sequencing to discover transcriptional differences in various cell types be... | 10.1111/acel.13800 | 36,797,808 | D051379:Mice; D000818:Animals; D032383:Myocytes, Cardiac; D011494:Protein Kinases; D011773:Pyruvates; D000375:Aging | Aging cell | 2,023 | C403287:pyruvate dehydrogenase kinase 4; D011494:Protein Kinases; D011773:Pyruvates |
[Twins and the heritability of dentofacial phenotype]. | In orthodontics and dentofacial orthopaedics, where genetic and environmental factors interpenetrate from the early stages of development, the clinician tries to determine how mechanics could influence patient's growth pattern. Comparing monozygotic and dizygotic twins, in their similarities and their differences, give... | 10.1051/orthodfr:2007004 | 17,571,534 | D001696:Biomechanical Phenomena; D004200:Diseases in Twins; D004777:Environment; D006801:Humans; D008310:Malocclusion; D008445:Maxillofacial Development; D010641:Phenotype; D014071:Tooth Abnormalities; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic | L' Orthodontie francaise | 2,007 | |
The epidemiology of osteoarthritis: Manchester and beyond. | The paper describes the contribution made to the understanding of the epidemiology of osteoarthritis by the Arthritis Research Campaign Epidemiology Unit. Kellgren and Lawrence defined the condition radiographically and produced the widely used Atlas of Standard Radiographs of Arthritis. They documented the age- and se... | 10.1093/rheumatology/kei058 | 16,306,479 | D001175:Arthrography; D004739:England; D004812:Epidemiologic Methods; D005544:Forecasting; D006801:Humans; D010003:Osteoarthritis; D012107:Research Design | Rheumatology (Oxford, England) | 2,005 | |
Role of Patient- and Surgery-Specific Risk in Receipt of Outpatient Preoperative Testing. | OBJECTIVE
To determine the independent association of patient- and surgery-specific risk with receipt of outpatient preoperative testing.
METHODS
Using administrative data from 2010-2013 (Marketscan® Commercial Claims and Encounters), we constructed a retrospective cohort of 678,368 privately-insured, non-elderly US ... | 10.1016/j.pcorm.2018.03.001 | 30,345,397 | Perioperative care and operating room management | 2,018 | ||
Granuloma annulare presenting as multiple nodules on the pinna. | Granuloma annulare is a benign, idiopathic, inflammatory dermatosis characterized clinically by dermal papules and annular plaques. We describe the case of a 40-year-old man who presented with a long history of multiple nodules on the left pinna. Histological examination revealed the typical necrobiotic granulomas of g... | 10.1258/0022215041917916 | 15,453,942 | D000328:Adult; D001706:Biopsy; D004427:Ear Diseases; D004431:Ear, External; D016460:Granuloma Annulare; D006801:Humans; D008297:Male | The Journal of laryngology and otology | 2,004 | |
Interpreting low praziquantel cure rates of Schistosoma mansoni infections in Senegal. | Praziquantel is currently the drug of choice for the treatment of schistosomiasis. Selective treatment of Schistosoma mansoni infections in various endemic countries usually present cure rates of >70% when using the standard dose of 40 mg kg(-1) body weight of praziquantel. However, unusually low cure rates (18-38%) ha... | 10.1016/s1471-4922(01)02209-7 | 11,854,090 | D000818:Animals; D000871:Anthelmintics; D004351:Drug Resistance; D006801:Humans; D011223:Praziquantel; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni; D012675:Senegal; D017211:Treatment Failure; D016896:Treatment Outcome | Trends in parasitology | 2,002 | D000871:Anthelmintics; D011223:Praziquantel |
Differences in the priming effect of various clades/subclades of inactivated H5N1 vaccine for booster injection with heterologous clades of vaccine strains. | The prime-boost response induced by different combinations of four H5N1 vaccines (NIBRG-14 (clade 1), Indo05/2005(H5N1)/PR8-IBCDC-RG2 (clade 2.1), A/Bar-Headed Goose/Qinhai Lake/1A/05 SJ163222 (clade 2.2), and Anhui01/2005(H5N1)-PR8-IBCDC-RG5 (clade 2.3.4)) was evaluated in mice. Clade 1-primed BALB/c mice showed a boo... | 10.1016/j.vaccine.2011.03.084 | 21,497,637 | D000818:Animals; D000914:Antibodies, Viral; D001402:B-Lymphocytes; D016207:Cytokines; D005260:Female; D005838:Genotype; D006385:Hemagglutination Inhibition Tests; D007117:Immunization, Secondary; D053124:Influenza A Virus, H5N1 Subtype; D007252:Influenza Vaccines; D008214:Lymphocytes; D051379:Mice; D008807:Mice, Inbred... | Vaccine | 2,011 | D000914:Antibodies, Viral; D016207:Cytokines; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated |
Trends in advanced imaging use for women undergoing breast cancer surgery. | BACKGROUND
Evidence-based guidelines recommend limited perioperative diagnostic imaging for new breast cancer diagnoses. For patients aged >65 years, conventional imaging use (mammography, plain radiographs, and ultrasound) has remained stable, whereas advanced imaging (computed tomography [CT], nuclear medicine scans ... | 10.1002/cncr.27838 | 23,212,691 | D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014055:Tomography, Emission-Computed; D055815:Young Adult | Cancer | 2,013 | |
Overview of current biological and thermo-chemical treatment technologies for sustainable sludge management. | Sludge is a semi-solid residue produced from wastewater treatment processes. It contains biodegradable and recalcitrant organic compounds, as well as pathogens, heavy metals, and other inorganic constituents. Sludge can also be considered a source of nutrients and energy, which could be recovered using economically via... | 10.1177/0734242X14538303 | 24,980,032 | D001673:Biodegradation, Environmental; D052918:Environmental Restoration and Remediation; D012722:Sewage; D014865:Waste Disposal, Fluid | Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA | 2,014 | D012722:Sewage |
Vergence errors: some hitherto unreported aspects of fixation disparity. | Measurement of the monocular components of fixation disparity indicated a higher prevalence of asymmetric contributions to the total deviation than previously reported. Furthermore, the exact proportion varied from moment to moment. Two of six subjects showed significant changes in fixation disparity over a period of 1... | 10.1097/00006324-199207000-00005 | 1,635,757 | D003290:Convergence, Ocular; D005133:Eye Movements; D006801:Humans; D015357:Vision Disparity; D015349:Vision, Monocular | Optometry and vision science : official publication of the American Academy of Optometry | 1,992 | |
Acquisition and use of linguistic knowledge: scrambling in child Japanese as a test case. | The current study investigates preschool-age children's comprehension of scrambled sentences in Japanese. While scrambling has been known to be challenging for children, biasing them to exhibit non-adult-like interpretations (e.g., Hayashibe in Descr Appl Linguist 8:1-18, 1975; Sano in Descr Appl Linguist 10:213-233, 1... | 10.1007/s10936-014-9347-x | 25,636,488 | D002648:Child; D002675:Child, Preschool; D032882:Comprehension; D005260:Female; D006801:Humans; D007564:Japan; D007802:Language; D007804:Language Development; D008037:Linguistics; D008297:Male; D013067:Speech Perception | Journal of psycholinguistic research | 2,015 | |
Five-Year Biochemical Results, Toxicity, and Patient-Reported Quality of Life After Delivery of Dose-Escalated Image Guided Proton Therapy for Prostate Cancer. | PURPOSE
To report clinical outcomes in patients treated with image guided proton therapy (PT) for localized prostate cancer.
METHODS AND MATERIALS
The medical records of 1327 men were reviewed. Each man was enrolled on an outcomes tracking study. Dual enrollment on a prospective clinical trial was allowed. Each patie... | 10.1016/j.ijrobp.2016.02.038 | 27,084,658 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D058958:Organs at Risk; D011446:Prospective Studies; D017430:Prostate-Specific Antigen; D01147... | International journal of radiation oncology, biology, physics | 2,016 | D000726:Androgen Antagonists; D017430:Prostate-Specific Antigen |
Transcription and translation in a package deal: the TISU paradigm. | The major strategy for cap dependent translation involves ribosomal scanning. In the scanning mechanism the small ribosomal subunit is recruited to the mRNA through the m7G cap and then scans the 5' UTR until it reaches an AUG codon. This short review focuses on a recently discovered alternative strategy of cap-depende... | 10.1016/j.gene.2011.09.013 | 21,983,420 | D020121:5' Untranslated Regions; D000818:Animals; D018387:Codon, Initiator; D006801:Humans; D010442:Peptide Chain Initiation, Translational; D012315:RNA Caps; D014158:Transcription, Genetic | Gene | 2,012 | D020121:5' Untranslated Regions; D018387:Codon, Initiator; D012315:RNA Caps |
Oxygen and Bis(3',5')-cyclic Dimeric Guanosine Monophosphate Binding Control Oligomerization State Equilibria of Diguanylate Cyclase-Containing Globin Coupled Sensors. | Bacteria sense their environment to alter phenotypes, including biofilm formation, to survive changing conditions. Heme proteins play important roles in sensing the bacterial gaseous environment and controlling the switch between motile and sessile (biofilm) states. Globin coupled sensors (GCS), a family of heme protei... | 10.1021/acs.biochem.6b00526 | 27,933,792 | D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D001665:Binding Sites; D055162:Biocatalysis; D018441:Biofilms; D001886:Bordetella pertussis; D006152:Cyclic GMP; D029968:Escherichia coli Proteins; D005914:Globins; D006418:Heme; D006420:Hemeproteins; D007700:Kinetics; D008958:Models, Molecular; D009154:Mutation;... | Biochemistry | 2,016 | D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D006420:Hemeproteins; D006418:Heme; C062025:bis(3',5')-cyclic diguanylic acid; D005914:Globins; D019761:Phosphorus-Oxygen Lyases; C060720:diguanylate cyclase; D006152:Cyclic GMP; D010100:Oxygen |
A Selective Tether Recruits Activated Response Regulator CheB to Its Chemoreceptor Substrate. | Methylesterase/deamidase CheB is a key component of bacterial chemotaxis systems. It is also a prominent example of a two-component response regulator in which the effector domain is an enzyme. Like other response regulators, CheB is activated by phosphorylation of an aspartyl residue in its regulatory domain, creating... | 10.1128/mBio.03106-21 | 34,809,457 | D001426:Bacterial Proteins; D001665:Binding Sites; D002265:Carboxylic Ester Hydrolases; D002633:Chemotaxis; D019281:Dimerization; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D007700:Kinetics; D010455:Peptides; D010766:Phosphorylation; D011485:Protein Binding; D000072417:Protein Domains; D011956:Recepto... | mBio | 2,021 | D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D010455:Peptides; D011956:Receptors, Cell Surface; C057331:Tar protein, E coli; D002265:Carboxylic Ester Hydrolases; C041144:chemotactic protein methylesterase |
An Exploratory Study of Influenza Vaccination Coverage in Healthcare Workers in a Western Chinese City, 2018-2019: Improving Target Population Coverage Based on Policy Interventions. | Objectives: To evaluate a policy-based intervention to increase seasonal-influenza-vaccination coverage in healthcare workers in Xining, a city in Western China. Methods: From October 2018 to March 2019, we implemented a free vaccination policy in healthcare workers in Xining. A face-to-face interview with the head of ... | 10.3390/vaccines8010092 | 32,093,085 | Vaccines | 2,020 | ||
Rat growth-hormone release stimulators from fenugreek seeds. | Bioassay-guided fractionation of MeOH extract from fenugreek (Trigonella foenum-graecum L.) seeds resulted in the isolation of two rat growth-hormone release stimulators in vitro, fenugreek saponin I (1) and dioscin (9), along with two new, i.e., 2 and 3, and five known analogues, i.e., 4-8. The structures of the new s... | 10.1002/cbdv.200890164 | 18,816,528 | D000818:Animals; D002478:Cells, Cultured; D013006:Growth Hormone; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D010902:Pituitary Gland; D010936:Plant Extracts; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D029910:Trigonella | Chemistry & biodiversity | 2,008 | D010936:Plant Extracts; D013006:Growth Hormone |
Vibrio algivorus sp. nov., an alginate- and agarose-assimilating bacterium isolated from the gut flora of a turban shell marine snail. | An agarose- and alginate-assimilating, Gram-reaction-negative, non-motile, rod-shaped bacterium, designated strain SA2T, was isolated from the gut of a turban shell sea snail (Turbo cornutus) collected near Noto Peninsula, Ishikawa Prefecture, Japan. The 16S rRNA gene sequence of strain SA2T was 99.59 % identical to th... | 10.1099/ijsem.0.001165 | 27,199,227 | D000464:Alginates; D000818:Animals; D059001:Aquatic Organisms; D015373:Bacterial Typing Techniques; D001482:Base Composition; D004269:DNA, Bacterial; D005227:Fatty Acids; D000069196:Gastrointestinal Microbiome; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D007564:Japan; D009693:Nucleic Acid Hybridization; D010743:... | International journal of systematic and evolutionary microbiology | 2,016 | D000464:Alginates; D004269:DNA, Bacterial; D005227:Fatty Acids; D006603:Hexuronic Acids; D010743:Phospholipids; D012336:RNA, Ribosomal, 16S; D014451:Ubiquinone; D020723:Glucuronic Acid; D012685:Sepharose; C030778:ubiquinone 8 |
Smoking, sex, risk factors and abdominal aortic aneurysms: a prospective study of 18 782 persons aged above 65 years in the Southern Community Cohort Study. | BACKGROUND
Abdominal aortic aneurysm (AAA) is a leading cause of death in the USA. We evaluated the incidence and predictors of AAA in a prospectively followed cohort.
METHODS
We calculated age-adjusted AAA incidence rates (IR) among 18 782 participants aged ≥65 years in the Southern Community Cohort Study who receiv... | 10.1136/jech-2014-204920 | 25,563,744 | D000328:Adult; D001741:Black or African American; D000368:Aged; D017544:Aortic Aneurysm, Abdominal; D002318:Cardiovascular Diseases; D015897:Comorbidity; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016016:Propo... | Journal of epidemiology and community health | 2,015 | |
Hypertension as a cardiometabolic risk. | Hypertension is a syndrome that extends beyond high blood pressure and often includes obesity, insulin resistance, altered lipid metabolism and other risk factors. The clustering of risk factors can place even a patient with a modestly elevated blood pressure at high risk for cardiovascular morbidity and mortality. Man... | 23,189,879 | D006801:Humans; D006973:Hypertension; D007333:Insulin Resistance; D050356:Lipid Metabolism; D024821:Metabolic Syndrome; D009765:Obesity; D012307:Risk Factors | Indian heart journal | 2,010 | ||
Influence of vacuum or high-oxygen modified atmosphere packaging on quality of beef M. longissimus dorsi steaks after different ageing times. | The objective of the study was to determine if beef quality parameters differ between steaks in modified atmosphere packaging (MAP; 80% O₂and 20% CO₂) and in vacuum packaging. Both M. longissimus dorsi (LD) from ten young bulls were cut in steaks day 3 postmortem and frozen either directly or after storage for 5 or 15 ... | 10.1016/j.meatsci.2010.08.010 | 20,934,260 | D000818:Animals; D002417:Cattle; D003116:Color; D018857:Food Packaging; D005524:Food Technology; D008460:Meat; D008786:Metmyoglobin; D018482:Muscle, Skeletal; D010100:Oxygen; D013314:Stress, Mechanical; D014618:Vacuum; D024502:alpha-Tocopherol | Meat science | 2,011 | D008786:Metmyoglobin; D024502:alpha-Tocopherol; D010100:Oxygen |
The Way of Severe Nursing of Respiratory System Failure. | Respiratory failure is the most common clinical symptom, seriously endangering people's health, which is mainly caused by a series of reasons, leading to serious respiratory dysfunction and severe pulmonary respiratory disorders, damaging the pulmonary airway function, and causing disability to maintain normal human ga... | 10.1155/2021/1667458 | 34,745,490 | D003422:Critical Care; D006801:Humans; D008168:Lung; D012119:Respiration; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency | Journal of healthcare engineering | 2,021 | |
Comparison of Vascular Closure Devices vs Manual Compression After Femoral Artery Puncture in Patients on Oral Anticoagulation - Post Hoc Analysis of the ISAR-CLOSURE Trial. | OBJECTIVES
To compare vascular closure devices (VCD) with manual compression (MC) in patients on chronic oral anticoagulation (OAC) who undergo diagnostic coronary angiography in terms of vascular access-site complications.
METHODS
This is a subanalysis of 604 patients that had undergone transfemoral diagnostic coron... | 34,170,841 | D000925:Anticoagulants; D005263:Femoral Artery; D006489:Hemostatic Techniques; D006801:Humans; D011677:Punctures; D016896:Treatment Outcome; D065506:Vascular Closure Devices | The Journal of invasive cardiology | 2,021 | D000925:Anticoagulants | |
Targeting CDC7 improves sensitivity to chemotherapy of esophageal squamous cell carcinoma. | PURPOSE
The cell division cycle 7 (CDC7) is a serine/threonine kinase that is essential for DNA replication in human cells which has been identified to play a critical role in multiple cancer types. However, the expression and clinical significance of CDC7 in ESCC has never been reported.
PATIENTS AND METHODS
CDC7 ex... | 10.2147/OTT.S183629 | 30,588,031 | OncoTargets and therapy | 2,019 | ||
Dictyocaulus viviparus in calves: quantitation of antibody activities in sera and respiratory secretions by immuno-enzymatic analysis. | An enzyme-linked immunosorbent assay (Elisa) which is in detail described here has been adapted to trace antibody production in different fluids from infected calves. Seven calves were infected both with Dictyocaulus viviparus, and with several intestinal nematodes. Antibodies against an antigen prepared from Dictyocau... | 161,491 | D000818:Animals; D000906:Antibodies; D002417:Cattle; D002418:Cattle Diseases; D004021:Dictyocaulus; D004022:Dictyocaulus Infections; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D008681:Metastrongyloidea; D012137:Respiratory System | Annales de recherches veterinaires. Annals of veterinary research | 1,979 | D000906:Antibodies; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G | |
Curcumin alleviates diabetic nephropathy via inhibiting podocyte mesenchymal transdifferentiation and inducing autophagy in rats and MPC5 cells. | Context: Curcumin could ameliorate diabetic nephropathy (DN), but the mechanism remains unclear.Objective: The efficacy of curcumin on epithelial-to-mesenchymal transition (EMT) of podocyte and autophagy in vivo and in vitro was explored.Materials and methods: Thirty male Sprague-Dawley rats were divided into the norma... | 10.1080/13880209.2019.1688843 | 31,741,405 | D000818:Animals; D001343:Autophagy; D018929:Cell Culture Techniques; D003474:Curcumin; D003928:Diabetic Nephropathies; D059305:Diet, High-Fat; D058750:Epithelial-Mesenchymal Transition; D007668:Kidney; D051379:Mice; D019869:Phosphatidylinositol 3-Kinases; D010936:Plant Extracts; D050199:Podocytes; D051057:Proto-Oncogen... | Pharmaceutical biology | 2,019 | D010936:Plant Extracts; D013311:Streptozocin; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; D003474:Curcumin |
Controlling decision errors with minimal costs: The sequential probability ratio t test. | For several years, the public debate in psychological science has been dominated by what is referred to as the reproducibility crisis. This crisis has, inter alia, drawn attention to the need for proper control of statistical decision errors in testing psychological hypotheses. However, conventional methods of error pr... | 10.1037/met0000234 | 31,497,982 | D003627:Data Interpretation, Statistical; D006801:Humans; D011336:Probability; D011584:Psychology; D015203:Reproducibility of Results; D012107:Research Design | Psychological methods | 2,020 | |
First Argentine database for the accurate identification of Brucella to species level by MALDI-TOF MS. | MALDI-TOF mass spectrometry (MS) has proven to be a fast and reliable method for the identification of a large number of taxonomic groups. It offers the advantage of being able to incorporate protein spectra of microorganisms that are absent or poorly represented in commercial databases, such as the genus Brucella. The... | 10.1016/j.actatropica.2023.107036 | 37,793,493 | D002002:Brucella; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D016208:Databases, Factual; D001118:Argentina | Acta tropica | 2,023 | |
[Acute benign erythroblastopenia with normochromic anemia in childhood (author's transl)]. | Two boys with acute benign erythroblastopenia are described. In contrast to patients with Gasser syndrome our two boys showed a severe normochromic anemia. Furthermore, no giant proerythroblasts were detectable in their bone marrow. A blockage of differentiation from hematopoietic stem cells to proerythroblasts is poss... | 834,194 | D000741:Anemia, Aplastic; D001803:Blood Transfusion; D001854:Bone Marrow Cells; D002675:Child, Preschool; D004900:Erythroblasts; D004912:Erythrocytes; D004920:Erythropoiesis; D006412:Hematopoietic Stem Cells; D006801:Humans; D008297:Male; D013577:Syndrome | Monatsschrift fur Kinderheilkunde | 1,977 | ||
[Characteristics of the spread pattern in esophageal carcinoma]. | The correlation of spread pattern with various clinical and histopathological factors was studied using macroscopic and microscopic findings of 284 patients who had undergone resection for esophageal carcinoma without pre-operative treatment. Macroscopic evaluation were made according to new classification proposed by ... | 2,607,707 | D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell; D004938:Esophageal Neoplasms; D005260:Female; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness | Kyobu geka. The Japanese journal of thoracic surgery | 1,989 | ||
Parathyroid adenoma causing persistent hypercalcaemia after rhabdomyolysis-induced acute renal failure. | Persistent hypercalcaemia developed in a 26-year-old man after rhabdomyolysis-induced acute renal failure. Although several serum parathyroid values were normal following recovery of renal function, primary hyperparathyroidism was suspected after 9 months of prolonged hypercalcaemia. A single parathyroid adenoma was re... | 3,110,663 | D058186:Acute Kidney Injury; D000236:Adenoma; D000328:Adult; D002334:Carnitine O-Palmitoyltransferase; D006801:Humans; D006934:Hypercalcemia; D008297:Male; D010282:Parathyroid Neoplasms; D012206:Rhabdomyolysis | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | 1,986 | D002334:Carnitine O-Palmitoyltransferase | |
Molecular recognition of avidin on biotin-functionalized gold surfaces detected by FT-IRRAS and use of metal carbonyl probes. | Fourier transform infrared reflection-absorption spectroscopy (FT-IRRAS) was successively used to monitor the covalent immobilization of biotin molecules onto a planar gold substrate covered with a self-assembled monolayer of cystamine and to transduce the molecular recognition of avidin and biotin. This detection was ... | 10.1006/jcis.2001.7981 | 16,290,351 | D001360:Avidin; D001710:Biotin; D004800:Enzymes, Immobilized; D006046:Gold; D015394:Molecular Structure; D009942:Organometallic Compounds; D011485:Protein Binding; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties | Journal of colloid and interface science | 2,002 | D004800:Enzymes, Immobilized; D009942:Organometallic Compounds; D001360:Avidin; D001710:Biotin; D006046:Gold |
Escherichia coli succinyl coenzyme A synthetase. Inhibition of ATP-stimulated succinate----succinyl coenzyme A exchange at low succinyl coenzyme A concentrations by an ADP trap. | The hypothesis that Escherichia coli succinyl-CoA synthetase functions by a cooperative alternating sites mechanism is based largely on the results of [18O]phosphate exchange experiments (Bild, G. S., Janson, C. A., and Boyer, P. D. (1980) J. Biol. Chem. 255, 8109-8115). In those experiments, [18O]Pi----succinate (pred... | 6,365,903 | D000214:Acyl Coenzyme A; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003066:Coenzyme A Ligases; D004926:Escherichia coli; D007700:Kinetics; D013389:Succinate-CoA Ligases; D013386:Succinates; D019802:Succinic Acid | The Journal of biological chemistry | 1,984 | D000214:Acyl Coenzyme A; D013386:Succinates; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D019802:Succinic Acid; C012046:succinyl-coenzyme A; D003066:Coenzyme A Ligases; D013389:Succinate-CoA Ligases | |
Relative quantitation of intact proteins of bacterial cell extracts using coextracted proteins as internal standards. | A method for quantitating protein expression using LC/MS of whole proteins is described. This method is based on the fact that some proteins present in cells are abundant universal proteins whose expression levels exhibit little variation. This method demonstrates that these coextracted proteins can be used as internal... | 10.1021/ac034820g | 14,961,731 | D001426:Bacterial Proteins; D002462:Cell Membrane; D002853:Chromatography, Liquid; D004926:Escherichia coli; D015870:Gene Expression; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins; D013058:Mass Spectrometry; D012015:Reference Standards | Analytical chemistry | 2,004 | D001426:Bacterial Proteins; D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins |
Absence of platelet-dependent fibrin formation in a patient with Scott syndrome. | To gain insight into the contribution of platelet-dependent thrombin formation in haemostasis and thrombosis, we investigated under flow conditions the haemostatic functions of platelets from a patient with Scott syndrome. Scott platelets are characterised by a diminished platelet-dependent thrombin generation. Thrombi... | 10.1160/TH08-11-0719 | 19,572,071 | D001777:Blood Coagulation; D001778:Blood Coagulation Disorders; D001792:Blood Platelets; D002118:Calcium; D005260:Female; D005337:Fibrin; D006470:Hemorrhage; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation; D012039:Regional Blood Flow; D013577:Syndrome; D013917:Thrombin; D013925:Thromboplastin | Thrombosis and haemostasis | 2,009 | D005337:Fibrin; D013925:Thromboplastin; D013917:Thrombin; D002118:Calcium |
Changes in refractive status in an elderly Chinese population in a 7-year follow-up: The Shihpai Eye Study. | BACKGROUND
Refractive error is the major cause of moderate and severe visual impairment. Visual impairment limits people's ability to perform daily tasks and affects their quality of life. Longitudinal data on the refractive status of the elderly was available only for whites and Africans. The purpose of this study was... | 10.1016/j.jcma.2017.06.004 | 28,716,601 | D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006956:Hyperopia; D015994:Incidence; D008297:Male; D009216:Myopia; D012030:Refractive Errors | Journal of the Chinese Medical Association : JCMA | 2,017 | |
Improvement of endocardial and vascular endothelial function on myocardial performance by captopril treatment in postinfarct rat hearts. | Background-Endocardial (EE) and myocardial capillary vascular endothelial (myocap VE) cells have been shown to modulate the contractile characteristics of myocardium in a calcium-dependent manner. We evaluated the endothelial-myocardial interaction in the rat postinfarction myocardial infarction (MI) model and the effe... | 10.1161/01.cir.100.12.1338 | 10,491,380 | D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D002196:Capillaries; D002216:Captopril; D003331:Coronary Vessels; D004699:Endocardium; D004730:Endothelium, Vascular; D006321:Heart; D007150:Immunohistochemistry; D009200:Myocardial Contraction; D009203:Myocardial Infarction; D009206:Myocardium; D019001... | Circulation | 1,999 | D000806:Angiotensin-Converting Enzyme Inhibitors; D012333:RNA, Messenger; D012701:Serotonin; D002216:Captopril; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat |
A Comparison of the Effects of Benzalkonium Chloride on Ocular Surfaces between C57BL/6 and BALB/c Mice. | Models of benzalkonium chloride (BAC)-induced ocular disruption have been created and are widely used in various animals. This study aimed to compare the effects of BAC on the ocular surfaces of C57BL/6 and BALB/c mice. C57BL/6 and BALB/c mice were treated separately with BAC eye-drops at different concentrations. Eyes... | 10.3390/ijms18030509 | 28,245,636 | D000818:Animals; D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds; D003228:Conjunctiva; D003315:Cornea; D004195:Disease Models, Animal; D005260:Female; D018836:Inflammation Mediators; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009883:Ophthalmic Solutions; D014985:Xeropht... | International journal of molecular sciences | 2,017 | D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds; D018836:Inflammation Mediators; D009883:Ophthalmic Solutions |
Sex differences in models of temporal lobe epilepsy: role of testosterone. | Kainic acid and pilocarpine were used to assess sex differences in temporal lobe seizures. Adult Sprague-Dawley rats were injected with kainic acid (10-12 mg/kg) or with pilocarpine (380 mg/kg) and behavior was recorded for the next 3 h. Trunk blood was collected for hormonal measurements. Our data indicate that the ma... | 10.1016/s0006-8993(02)02691-4 | 12,106,683 | D000818:Animals; D001522:Behavior, Animal; D001921:Brain; D003345:Corticosterone; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe; D018690:Excitatory Amino Acid Agonists; D005260:Female; D020022:Genetic Predisposition to Disease; D007030:Hypothalamo-Hypophyseal System; D007608:Kainic Acid; D008297:Male;... | Brain research | 2,002 | D018690:Excitatory Amino Acid Agonists; D018721:Muscarinic Agonists; D010862:Pilocarpine; D013739:Testosterone; D007608:Kainic Acid; D003345:Corticosterone |
Persistent organic pollutants (POPs) in edible fish species from different fishing zones of Croatian Adriatic. | High-risk contaminants, OCPs and PCBs, were investigated in marine fish from the Adriatic Sea, from which retail fish in Croatia is commonly sourced. The pollutant levels in sardine, horse and chub mackerel, anchovy and round sardinella were analysed based on a two-year sampling and the joint use of generally accepted ... | 10.1016/j.marpolbul.2018.10.014 | 30,503,488 | D000818:Animals; D017523:Croatia; D003634:DDT; D004784:Environmental Monitoring; D005399:Fishes; D001556:Hexachlorocyclohexane; D011078:Polychlorinated Biphenyls; D017747:Seafood; D014874:Water Pollutants, Chemical | Marine pollution bulletin | 2,018 | D014874:Water Pollutants, Chemical; C040534:alpha-hexachlorocyclohexane; D001556:Hexachlorocyclohexane; D003634:DDT; D011078:Polychlorinated Biphenyls |
Clinicopathological features of hemophilia in a tertiary care centre of India. | CONTEXT
Inherited bleeding disorders are common in India and hemophila and von Willebrand diseases are the most common among them. These patients can present in any department including paediatrics, medicine, orthopaedics and even gynaecology so knowledge about hemophilias and facilities for specialized tests for diagn... | 10.4103/jfmpc.jfmpc_1564_20 | 34,017,743 | Journal of family medicine and primary care | 2,021 | ||
Mapping Sleep Spindle Characteristics to Vigilance Outcomes in Patients with Obstructive Sleep Apnea. | Obstructive Sleep Apnea (OSA) is a sleep disorder associated with reduced vigilance. Vigilance status is often measured using the Psychomotor Vigilance Task (PVT). This paper investigates modelling strategies to map sleep spindle (Sp) characteristics to PVT metrics in patients with OSA. Sleep spindles (n=2305) were man... | 10.1109/EMBC46164.2021.9629998 | 34,891,389 | D006801:Humans; D017286:Polysomnography; D011597:Psychomotor Performance; D012890:Sleep; D020181:Sleep Apnea, Obstructive; D014851:Wakefulness | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference | 2,021 | |
Controlled encapsulation of multiple proteins in virus capsids. | Multiple proteins can be bound within the Cowpea Chlorotic Mottle Virus capsid shell in an efficient and controlled manner by using heterodimeric coiled-coil peptide oligomers. Through genetic modification, these oligomers can be attached to the capsid protein and an enhanced green fluorescent protein (EGFP). In this w... | 10.1021/ja907843s | 19,995,072 | D017795:Bromovirus; D002213:Capsid; D036022:Capsid Proteins; D049452:Green Fluorescent Proteins | Journal of the American Chemical Society | 2,009 | D036022:Capsid Proteins; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins |
Association of Cerebellar Tonsil Dynamic Motion and Outcomes in Pediatric Chiari I Malformation. | OBJECTIVE
Chiari I malformation (CM-1), traditionally defined as a descent of the cerebellar tonsils by 5 mm or more, is surgically managed via posterior fossa decompression. However, there is currently no clear radiologic or symptomatic selection criteria for surgical intervention to indicate which patients may see th... | 10.1016/j.wneu.2022.10.013 | 36,228,929 | D002648:Child; D006801:Humans; D012189:Retrospective Studies; D014066:Palatine Tonsil; D010865:Pilot Projects; D001139:Arnold-Chiari Malformation; D019299:Decompression, Surgical; D008279:Magnetic Resonance Imaging | World neurosurgery | 2,022 | |
Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. | Osteosarcoma (OS) in human patients is characterized by genetic alteration of TP53. Osteoprogenitor-specific p53-deleted mice (OS mice) have been widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms responsible for the development of OS upon p53 inactivation remain largely unknown.... | 10.1038/s41388-021-02120-w | 34,803,166 | D016159:Tumor Suppressor Protein p53 | Oncogene | 2,022 | D016159:Tumor Suppressor Protein p53 |
[Cases of hemophagocytic syndrome in Tenri Hospital]. | UNLABELLED
The author reviewed clinical and laboratory findings included white blood cells(WBC), C-reactive protein(CRP) in cases of hemophagocytic syndrome(HPS).
MATERIALS
Eleven cases of HPS treated in Tenri hospital between 1985 and 1999 were studied. HPS was diagnosed by clinical and laboratory findings. There we... | 11,064,597 | D000328:Adult; D000368:Aged; D000510:Alpha-Globulins; D001327:Autoimmune Diseases; D015415:Biomarkers; D002097:C-Reactive Protein; D002675:Child, Preschool; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell; D006801:Humans; D007223:Infant; D007564:Japan; D007958:Leukocyte Count; D008297:Male; D008875:Middle Ag... | Rinsho byori. The Japanese journal of clinical pathology | 2,000 | D000510:Alpha-Globulins; D015415:Biomarkers; D002097:C-Reactive Protein | |
Validation of a risk screening tool for pediatric type 1 diabetes patients: a predictor of increased acute health care utilization. | Background Both psychosocial and socioeconomic risk factors contribute to poor glycemic control (GC). Previous research has identified that diabetes care behaviors are generally 'set' by late childhood, further highlighting the importance of psychosocial screening and intervention in the early course of disease managem... | 31,490,774 | D015415:Biomarkers; D001786:Blood Glucose; D002648:Child; D003922:Diabetes Mellitus, Type 1; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin; D006801:Humans; D006943:Hyperglycemia; D007004:Hypoglycemic Agents; D015994:Incidence; D008297:Male; D008403:Mass Screening; D010342:Patient Acceptance of ... | Journal of pediatric endocrinology & metabolism : JPEM | 2,019 | D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin A; D007004:Hypoglycemic Agents; C517652:hemoglobin A1c protein, human | |
Heterologous post-infection immunity against Egyptian avian influenza virus (AIV) H9N2 modulates the course of subsequent infection by highly pathogenic AIV H5N1, but vaccination immunity does not. | In Egypt, zoonotic A/goose/Guangdong/1/96 (gs/GD-like) highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.2.1.2 is entrenched in poultry populations and has co-circulated with low-pathogenic avian influenza virus H9N2 of the G1 lineage since 2010. Here, the impact of H9N2 infection or vaccination on the co... | 10.1099/jgv.0.000767 | 28,590,242 | D000818:Animals; D002645:Chickens; D004534:Egypt; D053124:Influenza A Virus, H5N1 Subtype; D053127:Influenza A Virus, H9N2 Subtype; D007252:Influenza Vaccines; D005585:Influenza in Birds; D016019:Survival Analysis; D016896:Treatment Outcome; D015164:Vaccines, Inactivated; D022223:Vaccines, Subunit; D017201:Virus Sheddi... | The Journal of general virology | 2,017 | D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D022223:Vaccines, Subunit |
12-Tungstophosphoric acid/zirconia--a highly active stable solid acid--comparison with a tungstated zirconia catalyst. | A highly active and stable zirconia supported 12-tungstophosphoric acid catalyst is found to be 2-3 times more active in benzylation and acylation reactions than a tungstated zirconia catalyst. | 10.1039/b200722c | 12,122,671 | Chemical communications (Cambridge, England) | 2,002 | ||
[The functional status in patients with discopathy of the lumbar spine receiving only conservative therapy or operative therapy]. | UNLABELLED
Discopathy of lumbar spine inevitably leads to decreased quality of life in patients. Decrease of the backbone dysfunction at the degree which makes leading a life close to the normal style of family, social and professional life impossible, is the key therapeutic task. Evaluation of the functional disabilit... | 18,717,039 | D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D018450:Disease Progression; D017586:Diskectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007403:Intervertebral Disc; D007405:Intervertebral Disc Displacement; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle A... | Wiadomosci lekarskie (Warsaw, Poland : 1960) | 2,008 | ||
Influence of different covalent immobilization protocols on electroanalytical performance of laccase-based biosensors. | This paper presents a simple and effective flow-through electrochemical biosensor, consisting of Trametes versicolor laccase (Lac)-based mini-reactor and a tubular detector of silver solid amalgam (TD-AgSA), capable of rapid and selective detection of phenolic compounds. Amperometric detection relies on the reduction o... | 10.1016/j.bioelechem.2022.108223 | 35,973,323 | D015374:Biosensing Techniques; D002244:Carbon; D002482:Cellulose; D005976:Glutaral; D006108:Graphite; D042845:Laccase; D011208:Powders; D011809:Quinones; D012822:Silicon Dioxide; D012834:Silver; D055454:Trametes | Bioelectrochemistry (Amsterdam, Netherlands) | 2,022 | C509968:MCM-41; D011208:Powders; D011809:Quinones; D012834:Silver; D002244:Carbon; D012822:Silicon Dioxide; D006108:Graphite; D002482:Cellulose; D042845:Laccase; D005976:Glutaral |
Strategies for typing and properties of epidemic methicillin-resistant Staphylococcus aureus. | Isolates of 17 strains of epidemic methicillin-resistant Staphylococcus aureus from outbreaks in ten hospitals in the UK were investigated with a variety of techniques both to explore their properties and to type them in order to confirm or refute known or suspected epidemiology. The techniques consisted of a biotyping... | 10.1007/BF02013309 | 3,643,106 | D001434:Bacteriophage Typing; D003428:Cross Infection; D004196:Disease Outbreaks; D006801:Humans; D008712:Methicillin; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010457:Peptidoglycan; D010957:Plasmids; D013203:Staphylococcal Infections; D013211:Staphylococcus aureus; D006113:United Kingdom | European journal of clinical microbiology | 1,986 | D010457:Peptidoglycan; D008712:Methicillin |
The extradural temporopolar approach: a review of indications and operative technique. | OBJECT
The extradural temporopolar approach is used for enhanced exposure of the cavernous sinus and petroclival regions in the treatment of complex lesions not amenable to sole treatment via radiosurgical or endovascular methods. The authors' objective was to review the indications, surgical experience, and operative ... | 10.3171/FOC.2008.25.12.E3 | 19,035,701 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms; D002426:Cavernous Sinus; D004824:Epidural Space; D006801:Humans; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011859:Radiography; D012189:Retrospective Studies; D013701:Temporal Bone; D013702:Temporal Lobe; D... | Neurosurgical focus | 2,008 | |
Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies. | AMD is a major cause of legal blindness in older adults approachable through multidisciplinary research involving human tissues and patients. AMD is a vascular-metabolic-inflammatory disease, in which two sets of extracellular deposits, soft drusen/basal linear deposit (BLinD) and subretinal drusenoid deposit (SDD), co... | 10.1167/iovs.18-24882 | 30,357,336 | D001055:Apolipoproteins B; D001057:Apolipoproteins E; D006801:Humans; D008268:Macular Degeneration; D015593:Retinal Drusen; D055213:Retinal Pigment Epithelium | Investigative ophthalmology & visual science | 2,018 | D001055:Apolipoproteins B; D001057:Apolipoproteins E |
From Block Copolymer Nanotubes to Nanospheres: Nonsolvent-Induced Morphology Transformation Using Porous Templates. | Block copolymer nanostructures have attracted great attention because of the wide range of applications such as sensors and drug delivery. The fabrication of block copolymer nanostructures with controlled morphologies and sizes, however, is still challenging. Here, we study the fabrication of nanotubes and nanospheres ... | 10.1021/acs.langmuir.8b03250 | 30,376,343 | Langmuir : the ACS journal of surfaces and colloids | 2,018 | ||
Whose Right Is It Anyway? The Duties Owed to a Deceased and to Surviving Family Members When Dealing with a Corpse: Brennan v City of Bradford Metropolitan District Council and Leeds Teaching Hospitals NHS Trust [2021] 1 WLUK 429. | This commentary considers the case of Brennan, in which surviving family members successfully brought a Human Rights Act 1998 (HRA) claim against a hospital and a council for the way in which they both treated a body post-mortem. Their failure to freeze it led to such a state of decomposition that it was unfit for view... | 10.1093/medlaw/fwab029 | 34,406,389 | D002102:Cadaver; D005190:Family; D006784:Hospitals, Teaching; D006806:Human Rights; D006801:Humans; D013222:State Medicine | Medical law review | 2,022 | |
Identification of platelet receptors for bovine von Willebrand factor on human platelets by a new platelet receptor test. | A new test for the quantitation of platelet receptor activity for bovine von Willebrand factor in human platelet extracts is described. The test is based on the competition for the von Willebrand factor occurring between platelets, an antibody against von Willebrand factor, and platelet extracts containing the von Will... | 10.1016/0304-4165(81)90205-1 | 6,274,414 | D000818:Animals; D001779:Blood Coagulation Factors; D001792:Blood Platelets; D002417:Cattle; D006801:Humans; D007106:Immune Sera; D007700:Kinetics; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D014841:von Willebrand Factor | Biochimica et biophysica acta | 1,981 | D001779:Blood Coagulation Factors; D007106:Immune Sera; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D014841:von Willebrand Factor; C028254:von Willebrand factor receptor |
[In defense of society: the invention of palliative care and the production of subjectivities]. | This article is a theoretical reflection that is part of a study named Em Defesa da Sociedade: a invenção dos Cuidados Paliativos (In Defense of Society: the invention of Palliative Care). In order to articulate this discussion, we used the 2007edition of the Palliative Care Manual published by the World Health Organiz... | 22,576,552 | D006801:Humans; D062069:Inventions; D010166:Palliative Care; D013727:Terminal Care; D014944:World Health Organization | Revista da Escola de Enfermagem da U S P | 2,012 | ||
Comparative studies of the mutagenicity of environmental tobacco smoke from cigarettes that burn or primarily heat tobacco. | The mutagenicity of particulate matter concentrated from environmental tobacco smoke (ETS) from a prototype cigarette that primarily heats tobacco was compared to that of four popular commercially available cigarettes that burn tobacco. ETS was generated by six individuals simultaneously smoking 1 cigarette each in a 2... | 9,544,195 | D000393:Air Pollutants; D004353:Drug Evaluation, Preclinical; D006801:Humans; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D010947:Plants, Toxic; D012486:Salmonella typhimurium; D012906:Smoke; D014026:Nicotiana; D014028:Tobacco Smoke Pollution | Environmental and molecular mutagenesis | 1,998 | D000393:Air Pollutants; D009153:Mutagens; D012906:Smoke; D014028:Tobacco Smoke Pollution | |
Preoperative peripheral blood inflammatory markers especially the fibrinogen-to-lymphocyte ratio and novel FLR-N score predict the prognosis of patients with early-stage resectable extrahepatic cholangiocarcinoma. | Background
Systemic inflammation is important in the development of extrahepatic cholangiocarcinoma (ECC). The aim of this study was to compare the prognostic power of preoperative peripheral blood inflammatory markers and the novel FLR-N score in patients with resectable ECC.
Methods
A total of 140 patients with res... | 10.3389/fonc.2022.1003845 | 36,387,142 | Frontiers in oncology | 2,022 | ||
Reproductive physiology in Zebu cattle. Unique reproductive aspects that affect their performance. | This article describes the reproductive physiology of Zebu cattle and specific strategies that, when used in concert with an understanding of the physiologic differences between Zebu and other cattle, can improve reproductive performance. | 10.1016/s0749-0720(15)31134-8 | 3,319,088 | D000818:Animals; D002417:Cattle; D004971:Estrus; D004973:Estrus Synchronization; D005260:Female; D005298:Fertility; D007315:Insemination, Artificial; D008297:Male; D012726:Sexual Behavior, Animal | The Veterinary clinics of North America. Food animal practice | 1,987 | |
Robotic urological surgery in patients with prior abdominal operations is not associated with increased complications. | BACKGROUND
The da Vinci Surgical Robotic System is being increasingly used to perform complex urological operations by minimally invasive techniques. Prior abdominal surgery associated with intra-abdominal adhesions may complicate robotic surgery.
METHODS
We used a cohort of consecutive 49 patients undergoing a varie... | 10.1111/j.1442-2042.2006.01273.x | 16,643,618 | D034841:Abdominal Cavity; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012086:Reoperation; D012371:Robotics; D000267:Tissue Adhesions; D01... | International journal of urology : official journal of the Japanese Urological Association | 2,006 | |
Genetic parameters and evaluation of mortality and slaughter rate in Holstein and Jersey cows. | The longevity of dairy cattle has economic, animal welfare, and health implications and is influenced by the frequency of mortality on the farm and sale for slaughter. In this study cows removed from the herd due to death or slaughter during the lactation were coded 1 and cows that were not terminated were coded 0. Gen... | 10.3168/jds.2023-23471 | 37,641,312 | Journal of dairy science | 2,023 | ||
Liposome stability and formation: experimental parameters and theories on the size distribution. | The most important characteristics of liposomes, in addition to chemical composition and surface properties, are size distribution and lamellarity. Liposomes can be formed by many different preparation techniques, which according to the literature yield rather well defined vesicle preparations. In contrast to abundant ... | 10.1016/0009-3084(93)90056-9 | 8,242,841 | D004355:Drug Stability; D007700:Kinetics; D008051:Lipid Bilayers; D008081:Liposomes; D008433:Mathematics; D008854:Microscopy, Electron; D008962:Models, Theoretical; D008968:Molecular Conformation | Chemistry and physics of lipids | 1,993 | D008051:Lipid Bilayers; D008081:Liposomes |
[Tendinopathy of the tibialis anterior tendon : surgical management]. | A tendinopathy of the tibialis anterior tendon is a rare clinical problem. MRI is the diagnostic tool of choice. The first-line therapy should be conservative. We report about five patients who underwent operative therapy after failed conservative treatment. The operation included débridement and augmentation of the te... | 10.1007/s00132-010-1703-4 | 21,052,625 | D000328:Adult; D000842:Ankle; D003646:Debridement; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal; D011182:Postoperative Care; D011183:Postoperative Complications; D013536:Suture Techniques; D052256:Tendinopathy | Der Orthopade | 2,011 | |
Financing and provision of healthcare for two billion people in low-income nations: Is the cooperative healthcare model a solution? | The international consensus in support of universal health coverage (UHC), though commendable, thus far lacks a clear mechanism to finance and deliver accessible and effective basic healthcare to the two billion rural residents and informal workers of low- and lower-middle-income countries (LLMICs). Importantly, the tw... | 10.1016/j.socscimed.2023.115730 | 36,803,450 | Social science & medicine (1982) | 2,023 | ||
Localization of antibodies on spermatozoa and sperm movement characteristics are good predictors of in vitro fertilization success in cases of male autoimmune infertility. | OBJECTIVE
To define sperm factors related to in vitro fertilization (IVF) failure in cases of antisperm autoimmunity.
DESIGN
A detailed analysis of sperm morphology, movement characteristics, acrosomal function, and antibody binding was performed on the sperm population selected on a discontinuous two-layer Percoll g... | 10.1016/s0015-0282(16)55808-7 | 8,458,465 | D000177:Acrosome; D000328:Adult; D001323:Autoantibodies; D001327:Autoimmune Diseases; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male; D008297:Male; D013081:Sperm Motility; D013094:Spermatozoa | Fertility and sterility | 1,993 | D001323:Autoantibodies |
Presence, objecthood, and the phenomenology of predictive perception. | Can perceptual presence be explained by counterfactually-rich predictive models linking perception and action? Considering an unusually rich range of responses to this idea has led me to (1) re-emphasize the core conceptual commitment of "predictive processing of sensorimotor contingencies" (PPSMC) to predictive model-... | 10.1080/17588928.2015.1026888 | 25,849,361 | D006801:Humans; D010465:Perception; D010468:Perceptual Disorders; D010775:Photic Stimulation | Cognitive neuroscience | 2,015 | |
[Visual analysis of research progress of Sophorae Tonkinensis Radix et Rhizoma based on CiteSpace]. | To analyze the study advance of Sophorae Tonkinensis Radix et Rhizoma, this study utilized CiteSpace 5.6.R5 software to conduct bibliometrics analysis on the Chinese literatures of Sophorae Tonkinensis Radix et Rhizoma from 1990 to 2020 included in the CNKI database retrieval platform. The analysis contents involved th... | 10.19540/j.cnki.cjcmm.20201223.402 | 33,982,480 | D002681:China; D004365:Drugs, Chinese Herbal; D008516:Medicine, Chinese Traditional; D027343:Rhizome; D029909:Sophora | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | 2,021 | D004365:Drugs, Chinese Herbal |
Dual relationships in psychotherapy. | A dual relationship in psychotherapy occurs when the therapist engages in another, significantly different relationship with the patient. The two relationships may be concurrent or sequential. For both sexual and nonsexual dual relationships, men are typically the perpetrators and women are typically the victims. This ... | 10.1207/s15327019eb0101_3 | 11,649,348 | D001290:Attitude; D032781:Codes of Ethics; D016265:Conflict of Interest; D003625:Data Collection; D004467:Economics; D004651:Employment; D004995:Ethics, Professional; D005260:Female; D006282:Health Personnel; D006801:Humans; D007398:Interpersonal Relations; D008571:Men; D010361:Patients; D028743:Professional Misconduct... | Ethics & behavior | 1,991 | |
Successful management of malignant hyperpyrexia syndrome in a pediatric patient: What to do when dantrolene is not available? | Malignant hyperpyrexia syndrome (MHS) is a rare entity and may not be encountered by the anaesthesiologists throughout their professional career. Whenever it manifests can be a challenging task to manage and prove to be fatal when a timely diagnosis and required therapeutic measures are not taken. Althoughthe dantrolen... | 10.4103/0976-500X.171873 | 26,816,473 | Journal of pharmacology & pharmacotherapeutics | 2,015 | ||
Why Is Oral Phenylephrine on the Market After Compelling Evidence of Its Ineffectiveness as a Decongestant? | Ineffective over-the-counter (OTC) drugs should be removed from the US market. Despite solid research showing that oral phenylephrine is ineffective as a decongestant, the US Food and Drug Administration has failed to respond to a 2015 citizen's petition to remove it from the OTC nasal decongestant monograph. Other exa... | 10.1177/10600280221081526 | 35,337,187 | The Annals of pharmacotherapy | 2,022 | ||
Genetic dissection of cold tolerance at the budding stage of rice in an indica-japonica recombination inbred line population. | Rice is highly cold-sensitive, and thus, the promotion of cold resistance in buds is essential. In this study, we conducted a mapping analysis to identify quantitative trait loci (QTLs) associated with cold tolerance in buds. The analysis was performed using a recombinant inbred line (RIL) population consisting of 192 ... | 10.1016/j.plaphy.2023.108086 | 37,890,228 | D002874:Chromosome Mapping; D012275:Oryza; D000069600:Plant Breeding; D040641:Quantitative Trait Loci; D011995:Recombination, Genetic; D003080:Cold Temperature; D010641:Phenotype | Plant physiology and biochemistry : PPB | 2,023 | |
Short-term effects of particulate air pollution on male smokers and never-smokers. | BACKGROUND
Numerous studies have shown that ambient air pollution and smoking are both associated with increased mortality, but until now there has been little evidence as to whether the effects of these 2 factors combined are greater than the sum of their individual effects. We assessed whether smokers are subject to ... | 10.1097/EDE.0b013e318125713c | 17,700,248 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants; D000397:Air Pollution; D002318:Cardiovascular Diseases; D002423:Cause of Death; D006723:Hong Kong; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D009026:Mortality; D052638:Particulate Matter; D016012:Poisso... | Epidemiology (Cambridge, Mass.) | 2,007 | D000393:Air Pollutants; D052638:Particulate Matter |
Risk of respiratory syncytial virus in survivors with severe congenital diaphragmatic hernia. | BACKGROUND
During the follow-up period in surviving patients with severe congenital diaphragmatic hernia (CDH), respiratory complications, such as recurrence of CDH or chronic lung disease, have been reported to occur as a late complication. Although some risk factors for deterioration of respiratory condition have bee... | 10.1111/j.1442-200X.2008.02580.x | 19,143,967 | D005260:Female; D006548:Hernia, Diaphragmatic; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012008:Recurrence; D018357:Respiratory Syncytial Virus Infections; D012307:Risk Factors | Pediatrics international : official journal of the Japan Pediatric Society | 2,008 | |
William Butler (1535-1618): A biography of a singular physician. | William Butler (1535-1618) was a man without a medical degree who was styled as the 'greatest physician of his age'. He was famous in his lifetime, and in the latter stages of his career was involved with the royal court, attending to King James I and his son, Prince Henry. Butler was an empiricist who practiced confid... | 10.1177/09677720221146546 | 36,594,501 | Journal of medical biography | 2,023 | ||
NMR Signal Quenching from Bound Biradical Affinity Reagents in DNP Samples. | We characterize the effect of specifically bound biradicals on the NMR spectra of dihydrofolate reductase from E. coli. Dynamic nuclear polarization methods enhance the signal-to-noise of solid state NMR experiments by transferring polarization from unpaired electrons of biradicals to nuclei. There has been recent inte... | 10.1021/acs.jpcb.7b08274 | 29,116,793 | D004926:Escherichia coli; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013762:Tetrahydrofolate Dehydrogenase | The journal of physical chemistry. B | 2,017 | D008024:Ligands; D013762:Tetrahydrofolate Dehydrogenase |
[Multifocal choroidal ischemia in preeclampsia: report of two cases]. | INTRODUCTION
Multifocal choroidal ischemia is a complication of severe hypertension, notably in preeclampsia. It is a rare phenomenon due to multiple choriocapillaris occlusions.
CLINICAL OBSERVATIONS
We report the cases of two patients, age 28 and 32 years, 34 and 26 weeks since last menstrual period, respectively. ... | 24,559,529 | D000328:Adult; D002829:Choroid; D005260:Female; D006801:Humans; D007511:Ischemia; D011225:Pre-Eclampsia; D011247:Pregnancy | Journal francais d'ophtalmologie | 2,014 | ||
Non-Glycanated Biglycan and LTBP4: Leveraging the extracellular matrix for Duchenne Muscular Dystrophy therapeutics. | The extracellular matrix (ECM) plays key roles in normal and diseased skeletal and cardiac muscle. In healthy muscle the ECM is essential for transmitting contractile force, maintaining myofiber integrity and orchestrating cellular signaling. Duchenne Muscular Dystrophy (DMD) is caused by loss of dystrophin, a cytosoli... | 10.1016/j.matbio.2018.02.016 | 29,481,844 | D000818:Animals; D058578:Biglycan; D002462:Cell Membrane; D002986:Clinical Trials as Topic; D005109:Extracellular Matrix; D015316:Genetic Therapy; D006801:Humans; D053779:Latent TGF-beta Binding Proteins; D018482:Muscle, Skeletal; D020388:Muscular Dystrophy, Duchenne | Matrix biology : journal of the International Society for Matrix Biology | 2,018 | C546884:BGN protein, human; D058578:Biglycan; C509040:LTBP4 protein, human; D053779:Latent TGF-beta Binding Proteins |
Adaptive evidence of mitochondrial genomes in Dolycoris baccarum (Hemiptera: Pentatomidae) to divergent altitude environments. | Given mitochondrion is the 'energy and oxygen usage factories', adaptive signatures of mitochondrial genes have been extensively investigated in vertebrates from different altitudes, but few studies focus on insects. Here, we sequenced the complete mitochondrial genome (mitogenome) of Dolycoris. baccarum living in the ... | 10.1080/24701394.2018.1446951 | 29,521,177 | D000222:Adaptation, Physiological; D000531:Altitude; D000818:Animals; D019143:Evolution, Molecular; D054629:Genome, Mitochondrial; D006430:Hemiptera; D012641:Selection, Genetic | Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis | 2,019 | |
The role of easily released substances (ERS) from bacteria in physiologic solution in natural immunity. VI. Induction of opsonins for different genera of bacteria by ERS from Staph. aureus oxford. | ERS obtained from Staph. aureus by mild extraction with physiologic saline solution possess activity of inducing nonspecific opsonins which react with homologous bacteria and with related Gram-negative bacteria. ERS from Staph. aureus weakly stimulated precipitins and antibodies active in passive hemagglutination and i... | 337,934 | D000117:Acetylglucosamine; D000818:Animals; D000907:Antibodies, Bacterial; D002457:Cell Extracts; D004926:Escherichia coli; D006168:Guinea Pigs; D007113:Immunity, Innate; D009895:Opsonin Proteins; D010587:Phagocytosis; D011817:Rabbits; D012486:Salmonella typhimurium; D012764:Shigella sonnei; D012965:Sodium Chloride; D0... | Archivum immunologiae et therapiae experimentalis | 1,977 | D000907:Antibodies, Bacterial; D002457:Cell Extracts; D009895:Opsonin Proteins; D014020:Tissue Extracts; D012965:Sodium Chloride; D000117:Acetylglucosamine | |
Bergamot Aromatherapy for Medical Office-Induced Anxiety Among Children With an Autism Spectrum Disorder: A Randomized, Controlled, Blinded Clinical Trial. | This randomized, blinded clinical trial evaluated the effects of aromatherapy on medical office-induced anxiety in children with an autism spectrum disorder. Patients awaiting office visits were randomized into an aromatherapy group and a control group. After adjusting for baseline scores, there was no significant diff... | 10.1097/HNP.0000000000000341 | 31,415,008 | D001007:Anxiety; D019341:Aromatherapy; D000067877:Autism Spectrum Disorder; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009817:Office Management; D010938:Plant Oils | Holistic nursing practice | 2,019 | D010938:Plant Oils |
Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. | Overall dietary energy intake, particularly the consumption of simple sugars such as fructose, has been increasing steadily in Western societies, but the effects of such diets on the brain are poorly understood. Here, we used functional and structural assays to characterize the effects of excessive caloric intake on th... | 10.1002/hipo.20470 | 18,651,634 | D000818:Animals; D019208:Brain-Derived Neurotrophic Factor; D003071:Cognition; D004032:Diet; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005455:Fluorescent Antibody Technique; D006624:Hippocampus; D007333:Insulin Resistance; D009473:Neuronal Plasticity; D051381:Rats | Hippocampus | 2,008 | D019208:Brain-Derived Neurotrophic Factor; D004040:Dietary Carbohydrates; D004041:Dietary Fats |
Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence? | It is still debatable whether congenital Plasmodium falciparum malaria is a rarity or a frequent occurrence in sub-Saharan Africa. The objective of this report is to review scientific information and findings from investigations conducted in sub-Saharan Africa on the occurrence of congenital malaria to highlight the ne... | 10.1007/s00436-007-0577-9 | 17,549,517 | D017954:Africa South of the Sahara; D000818:Animals; D000962:Antimalarials; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016778:Malaria, Falciparum; D018512:Parasitemia; D010963:Plasmodium falciparum; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D015995:Prevalence | Parasitology research | 2,007 | D000962:Antimalarials |
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