title large_stringlengths 0 979 | abstract large_stringlengths 1 94.7k | doi large_stringlengths 0 71 | pmid int64 21 38.1M | mesh_terms large_stringlengths 0 1.47k | journal large_stringlengths 1 239 | pubdate int16 1.97k 2.02k | chemical_list large_stringlengths 0 1.47k |
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The influence of long-term supplementation with biotin on the prevention of lameness in pasture fed dairy cows. | In a double-blind study, the influence of biotin supplementation on lameness in dairy cows was investigated over a 13-mo period. The experimental site was a tropical upland environment and involved over 2705 Holstein and Friesian cows on 20 participating farms. Cows on 10 farms received biotin at a rate of 20 mg/head p... | 10.3168/jds.S0022-0302(00)74884-3 | 10,714,870 | D000821:Animal Feed; D000818:Animals; D001710:Biotin; D002417:Cattle; D002418:Cattle Diseases; D002452:Cell Count; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006724:Hoof and Claw; D007774:Lactation; D007794:Lameness, Animal; D008892:Milk; D008894:Milk Proteins; D011793:Queensland; D01189... | Journal of dairy science | 2,000 | D008894:Milk Proteins; D001710:Biotin |
Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus. | Chromatographic separation of the liquid culture filtrate of the basidiomycete fungus Physisporinus sanguinolentus has yielded three new compounds viz., 2-methyl-4-pyrone, 2-methyl-5,6-dihydro-4-pyrone and the pyridone form of 4-hydroxy-2-methylpyridine, together with the known triacetic acid lactone, the sesquiterpene... | 10.1016/s0031-9422(00)00414-3 | 11,314,963 | D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D011124:Polyporaceae; D011728:Pyridones; D011753:Pyrones | Phytochemistry | 2,001 | D003470:Culture Media; D011728:Pyridones; D011753:Pyrones |
The probiotic Lactobacillus acidophilus reduces cholesterol absorption through the down-regulation of Niemann-Pick C1-like 1 in Caco-2 cells. | Elevated blood cholesterol is an important risk factor associated with atherosclerosis and CHD. The search for mediators that fine tune cholesterol homeostasis has recognised probiotics as being potentially beneficial. Here, we present data describing bacterial regulation of Niemann-Pick C1-like 1 (NPC1L1), which, when... | 10.1017/S0007114509991991 | 19,814,836 | D000924:Anticholesteremic Agents; D018938:Caco-2 Cells; D002784:Cholesterol; D015536:Down-Regulation; D015870:Gene Expression; D006801:Humans; D006937:Hypercholesterolemia; D007408:Intestinal Absorption; D007779:Lactobacillus acidophilus; D000071518:Liver X Receptors; D008565:Membrane Proteins; D026901:Membrane Transpo... | The British journal of nutrition | 2,010 | D000924:Anticholesteremic Agents; D000071518:Liver X Receptors; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D008823:Micelles; C410800:NPC1L1 protein, human; D057093:Orphan Nuclear Receptors; D002784:Cholesterol |
Study of upper gastrointestinal tract endoscopic findings in portal hypertension. | INTRODUCTION
The gut mucosa in portal hypertension is the seat of microcirculatory changes that compromise its integrity and increase its susceptibility to damage. The mucosal changes in portal hypertension may require pharmacological, directed endoscopic or portal decompressive therapy. The objective of the study is t... | 24,362,656 | D003430:Cross-Sectional Studies; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices; D005756:Gastritis; D006801:Humans; D006940:Hyperemia; D006975:Hypertension, Portal; D008103:Liver Cirrhosis; D011446:Prospective Studies; D013270:Stomach; D013272:Stomach Diseases | JNMA; journal of the Nepal Medical Association | 2,013 | ||
A 3D QSAR study of betulinic acid derivatives as anti-tumor agents using topomer CoMFA: model building studies and experimental verification. | Betulinic acid (BA) is a natural product that exerts its cytotoxicity against various malignant carcinomas without side effects by triggering the mitochondrial pathway to apoptosis. Betulin (BE), the 28-hydroxyl analog of BA, is present in large amounts (up to 30% dry weight) in the outer bark of birch trees, and share... | 10.3390/molecules180910228 | 23,973,995 | D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D002470:Cell Survival; D003198:Computer Simulation; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D021281:Quantitative Structu... | Molecules (Basel, Switzerland) | 2,013 | D000970:Antineoplastic Agents; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid |
How the Public Engages With Brain Optimization: The Media-mind Relationship. | In the burgeoning debate about neuroscience's role in contemporary society, the issue of brain optimization, or the application of neuroscientific knowledge and technologies to augment neurocognitive function, has taken center stage. Previous research has characterized media discourse on brain optimization as individua... | 10.1177/0162243915576374 | 26,336,326 | Science, technology & human values | 2,015 | ||
Sauchinone prevents TGF-β-induced EMT and metastasis in gastric cancer cells. | Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, was reported to possess diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects. However, the possible role of sauchinone in the epithelial-mesenchymal transition (EMT) remains unclear. Thu... | 10.1016/j.biopha.2018.02.121 | 29,499,410 | D001578:Benzopyrans; D045744:Cell Line, Tumor; D002465:Cell Movement; D004149:Dioxoles; D058750:Epithelial-Mesenchymal Transition; D005753:Gastric Mucosa; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D015398:Si... | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 2,018 | D001578:Benzopyrans; D004149:Dioxoles; D051899:Smad2 Protein; D051900:Smad3 Protein; D016212:Transforming Growth Factor beta; C410958:sauchinone; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt |
A cohort study using IL-6/Stat3 activity and PD-1/PD-L1 expression to predict five-year survival for patients after gastric cancer resection. | OBJECTIVES
The expression/activation of IL-6, p-Stat3, PD-1 and PD-L1 in gastric cancer (GC) tissues were examined to evaluate their abilities in predicting the survival prognosis in postoperative patients with GC.
METHODS
The clinicopathological data and paraffin-embedded tissues of 205 patients who underwent gastri... | 10.1371/journal.pone.0277908 | 36,454,780 | D006801:Humans; D008875:Middle Aged; D013274:Stomach Neoplasms; D060890:B7-H1 Antigen; D015850:Interleukin-6; D015331:Cohort Studies; D005743:Gastrectomy; D059016:Tumor Microenvironment; D050796:STAT3 Transcription Factor | PloS one | 2,022 | D060890:B7-H1 Antigen; D015850:Interleukin-6; C494086:STAT3 protein, human; D050796:STAT3 Transcription Factor |
Sex differences in the control of neuronal nitric oxide synthase by GABA-A receptors in the developing rat diencephalon. | The nitric oxide free radical (NO(*)), which is synthesized by neuronal nitric oxide synthase (nNOS), is known to play an important morphogenetic role in the developing rat brain. In the cortex, the levels of nNOS are regulated by phosphorylated cAMP response element binding protein (pCREB) downstream of GABA-A recepto... | 10.1016/j.brainres.2007.02.075 | 17,382,911 | D000818:Animals; D000831:Animals, Newborn; D017362:Cyclic AMP Response Element-Binding Protein; D004027:Diencephalon; D005260:Female; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D052248:Nitric Oxide Synthase Type I; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA... | Brain research | 2,007 | D017362:Cyclic AMP Response Element-Binding Protein; D011963:Receptors, GABA-A; D052248:Nitric Oxide Synthase Type I |
Trends in Adolescent Completed Suicide in Croatia for the Period of 2000 to 2020. | BACKGROUND
Croatia belongs to the countries with a medium mortality rate due to suicide in youths. Previous epidemiological reports indicated a decreasing trend of suicide rates in adolescents. However, recent trend analysis in youth suicide rates in Croatia are missing. This study aimed to describe recent trends in ch... | 10.24869/psyd.2022.715 | 36,548,886 | D002648:Child; D006801:Humans; D008297:Male; D000293:Adolescent; D005260:Female; D013405:Suicide; D017523:Croatia; D000081013:Suicide, Completed; D012042:Registries | Psychiatria Danubina | 2,022 | |
Physical inactivity and obesity: a vicious circle. | OBJECTIVE
Physical activity (PA) begins to decline in adolescence with a concomitant increase in weight. We hypothesized that a vicious circle may arise between decreasing PA and weight gain from adolescence to early adulthood.
METHODS AND PROCEDURES
PA and self-perceived physical fitness assessed in adolescents (16-... | 10.1038/oby.2007.72 | 18,239,652 | D000293:Adolescent; D000328:Adult; D001481:Basal Metabolism; D001835:Body Weight; D015331:Cohort Studies; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D009043:Motor Activity; D009765:Obesity; D011237:Predictive Value of Tests; D012307:Risk Fa... | Obesity (Silver Spring, Md.) | 2,008 | |
Expression of IFN-inducible protein-10 in chronic hepatitis. | Chemokines such as IFN-inducible protein-10 (IP-10) and JE/monocyte chemotactic protein-1 (MCP-1) are induced in the murine liver in a tissue-specific manner. We examined whether IP-10 and MCP-1 are pathologically involved in chronic hepatitis. Whereas the serum levels of IP-10 and MCP-1 in patients with chronic persis... | 9,164,978 | D018932:Chemokine CCL2; D002908:Chronic Disease; D016207:Cytokines; D006526:Hepatitis C; D006801:Humans; D017403:In Situ Hybridization; D020382:Interleukin-18; D008099:Liver | Journal of immunology (Baltimore, Md. : 1950) | 1,997 | D018932:Chemokine CCL2; D016207:Cytokines; D020382:Interleukin-18 | |
Associations between Inhaled Corticosteroid Use in the First 6 Years of Life and Obesity-related Traits. | Rationale: Infants and young children might be particularly likely to experience the potential clinical side effects of inhaled corticosteroids (ICSs) on body mass index (BMI), adiposity rebound (AR), and body composition, but this has rarely been studied in long-term studies in this age group. Objectives: To determine... | 10.1164/rccm.202009-3537OC | 33,975,528 | D015502:Absorptiometry, Photon; D050154:Adiposity; D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents; D001249:Asthma; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D016014:Linear Models; D008297:Male; D063766:Ped... | American journal of respiratory and critical care medicine | 2,021 | D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents |
Phenotyping Multiple Subsets of Immune Cells In Situ in Formalin-Fixed, Paraffin-Embedded Tissue Sections. | Some somatic illnesses such as peripheral tumours can present with psychiatric symptoms. Many of these are characterized by changes in biomarkers related to the inflammation or immune response. Here, we describe a multispectral imaging protocol that can be used to phenotype immune and other cell types through simultane... | 10.1007/978-3-319-52479-5_32 | 28,353,253 | D015415:Biomarkers; D005456:Fluorescent Dyes; D005470:Fluorometry; D005557:Formaldehyde; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016130:Immunophenotyping; D001523:Mental Disorders; D008856:Microscopy, Fluorescence; D009363:Neoplasm Proteins; D009369:Neoplasms; D009419:Nerve Tissue Proteins; D01661... | Advances in experimental medicine and biology | 2,017 | D015415:Biomarkers; D005456:Fluorescent Dyes; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D005557:Formaldehyde |
[Isolation and expression profiling of transformer 2 gene in Aedes aegypti]. | OBJECTIVE
To isolate, identify and analyze the sex-determining gene Transformer 2 (Aaetra2) of the major vector mosquito Aedes aegypti.
METHODS
tBLASTn program, RT-PCR and RACE methods were used to obtain the full-length cDNA of Aaetra2. Multiple alignments of nucleotide and amino acid sequences were conducted, and t... | 24,273,257 | D000330:Aedes; D000595:Amino Acid Sequence; D000818:Animals; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D019476:Insect Proteins; D009419:Nerve Tissue Proteins; D010802:Phylogeny; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; D016415:Sequence Alignm... | Nan fang yi ke da xue xue bao = Journal of Southern Medical University | 2,013 | D029721:Drosophila Proteins; D019476:Insect Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; C067777:Sxl protein, Drosophila; C097083:TRA2B protein, human; C066174:tra2 protein, Drosophila; D000068103:Serine-Arginine Splicing Factors | |
Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study. | Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgrou... | 10.1038/s41598-023-36235-9 | 37,296,301 | D006801:Humans; D012559:Schizophrenia; D011618:Psychotic Disorders; D035781:Siblings; D008137:Longitudinal Studies; D011788:Quality of Life | Scientific reports | 2,023 | |
Injuries caused by defensive bullet launchers and resource utilization during the French yellow vests protests: A retrospective study. | BACKGROUND
In 2018, the French "Yellow Vest" social protest movement spread with weekly demonstrations resulting in confrontations between protesters and law enforcement. Non-lethal weapons, such as defensive bullet launchers (DBL) were used, and significant injuries have been reported through media, leading to public ... | 10.1016/j.ajem.2023.07.023 | 37,523,992 | D000328:Adult; D006801:Humans; D012189:Retrospective Studies; D054041:Weapons; D006760:Hospitalization; D035846:Law Enforcement; D050723:Fractures, Bone | The American journal of emergency medicine | 2,023 | |
Differential recognition patterns of human immunoglobulin classes to antigens of Onchocerca gibsoni. | Adult Onchocerca gibsoni worms were fractionated into a surface-enriched fraction, a saline extract, a saline insoluble-detergent soluble fraction and a total glycoproteins extract. The antigens in each fractions were separated by electrophoresis in polyacrylamide gels and examined with an immuno-blot technique for rea... | 3,529,338 | D000818:Animals; D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007070:Immunoglobulin A; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007158:Immunologic Techniques; D009854:Onchocerca; D... | Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) | 1,986 | D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007073:Immunoglobulin E | |
PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts. | This work demonstrated the constitutive expression of peroxisome proliferator-activated receptor (PPAR)-gamma and PPAR-alpha in rat synovial fibroblasts at both mRNA and protein levels. A decrease in PPAR-gamma expression induced by 10 microg/ml lipopolysaccharide (LPS) was observed, whereas PPAR-alpha mRNA expression ... | 10.1152/ajpcell.2002.282.1.C125 | 11,742,805 | D000818:Animals; D000970:Antineoplastic Agents; D002478:Cells, Cultured; D002839:Chromans; D051546:Cyclooxygenase 2; D005347:Fibroblasts; D015870:Gene Expression; D007375:Interleukin-1; D007527:Isoenzymes; D008024:Ligands; D008070:Lipopolysaccharides; D008297:Male; D016328:NF-kappa B; D019001:Nitric Oxide Synthase; D05... | American journal of physiology. Cell physiology | 2,002 | D000970:Antineoplastic Agents; D002839:Chromans; D007375:Interleukin-1; D007527:Isoenzymes; D008024:Ligands; D008070:Lipopolysaccharides; D016328:NF-kappa B; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D045162:Thiazolidinediones; D018808:Transcription Factor AP-1; D014157:Tran... |
Assessment of an interactive microcomputer-videodisc programme for teaching medical students to evaluate the peripheral blood smear. | An interactive microcomputer-videodisc programme for providing instruction in interpreting the peripheral blood smear was evaluated by 23 medical students. The mean scores of the students on a test of interpretation of photomicrographs of blood smears increased significantly after use of the teaching programme. The stu... | 10.3109/01421599009006641 | 2,095,453 | D001772:Blood Cell Count; D003194:Computer-Assisted Instruction; D004501:Education, Medical; D006801:Humans; D008838:Microcomputers; D011795:Surveys and Questionnaires; D013663:Teaching; D014742:Videodisc Recording | Medical teacher | 1,990 | |
Precise measurement of B meson lifetimes with hadronic decay final states. | The lifetimes of the B(0) and B- mesons are extracted from 29.1 fb(-1) of data collected with the Belle detector at the KEK B factory. A fit to the decay length differences of neutral and charged B meson pairs, measured in events where one of the B mesons is fully reconstructed in several hadronic modes, yields tau(B(0... | 10.1103/PhysRevLett.88.171801 | 12,005,744 | Physical review letters | 2,002 | ||
[Establishment of RP-HPLC fingerprint for quality assessment of Cortex Periplocae]. | OBJECTIVE
To establish the RP-HPLC fingerprint analysis for the quality control of Cortex Periplocae.
METHODS
HPLC fingerprint and analysis method of Cortex Periplocae were studied. Kromasil C18 column (250 mm x 4.6 mm, 5 microm) was used, with mixture of acetonitrile and 0.025% phosphate solution as mobile phase in ... | 17,059,012 | D002851:Chromatography, High Pressure Liquid; D016000:Cluster Analysis; D004340:Drug Contamination; D004365:Drugs, Chinese Herbal; D031109:Periploca; D024301:Plant Bark; D018517:Plant Roots; D010946:Plants, Medicinal; D011786:Quality Control; D015203:Reproducibility of Results | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | 2,006 | D004365:Drugs, Chinese Herbal | |
[Killing effects of controllable expression of tumor necrosis factor-related apoptosis-inducing ligand from mesenchymal stem cells on hepatocellular carcinoma cells]. | OBJECTIVE
To study the controllable expression of soluble tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in mesenchymal stem cells and evaluate its potential tumoricidal effects in cancer therapy.
METHODS
The controllable TRAIL expression vector of Ad-Tet-TRE-TRAIL was established in an adenovirus ve... | 21,418,858 | D000256:Adenoviridae; D000818:Animals; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D005822:Genetic Vectors; D006801:Humans; D008113:Liver Neoplasms; D059630:Mesenchymal Stem Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D053220:Receptors, TNF-Related Apoptosis-Inducing Liga... | Zhonghua yi xue za zhi | 2,011 | D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand | |
Locomotion Mode Recognition with Inertial Signals for Hip Joint Exoskeleton. | Recognizing locomotion modes is a crucial step in controlling lower-limb exoskeletons/orthoses. Our study proposed a fuzzy-logic-based locomotion mode/transition recognition approach that uses the onrobot inertial sensors for a hip joint exoskeleton (active pelvic orthosis). The method outputs the recognition decisions... | 10.1155/2021/6673018 | 34,335,872 | Applied bionics and biomechanics | 2,021 | ||
First principles study of the stability of MXenes under an electron beam. | Interactions between two-dimensional MXene sheets and electron beams of a (scanning) transmission electron microscope are studied by first-principles calculations. We simulated the knock-on sputtering threshold for Ti3C2 MXene sheets via ab initio molecular dynamics simulations and for five other MXenes (Ti2C, Ti2N, Nb... | 10.1039/d0na00886a | 36,133,102 | Nanoscale advances | 2,021 | ||
The setting of a botulinum toxin treatment service. | The administration of botulinum toxin is an activity performed mostly by a specialist service for the management of a wide range of neurological conditions. For therapeutic purposes botulinum toxin type A is used, although in selected patients who develop antibodies specific for the serotype A botulinum toxin B can be ... | 10.1007/s10072-014-1742-4 | 24,867,836 | D065087:Acetylcholine Release Inhibitors; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A; D006761:Hospitals; D006801:Humans; D008881:Migraine Disorders; D009069:Movement Disorders; D009128:Muscle Spasticity; D009462:Neurology; D009465:Neuromuscular Agents | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2,014 | D065087:Acetylcholine Release Inhibitors; D009465:Neuromuscular Agents; C096323:rimabotulinumtoxinB; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A |
The effect of thiol compounds on the autolysis of papain. | Incubation of papain with 3--17.5 mM dithiothreitol and dithioerythritol at pH 8.5 causes inactivation owing to autolysis. Such inactivation is not observed on incubation with equivalent concentrations of mercaptoethanol, cysteine or 2,3-dimercaptopropanol. The inactivation rate is independent of papain concentration w... | 10.1111/j.1432-1033.1980.tb06154.x | 7,460,946 | D004226:Dithioerythritol; D004229:Dithiothreitol; D007700:Kinetics; D008956:Models, Chemical; D010206:Papain | European journal of biochemistry | 1,980 | D004226:Dithioerythritol; C028597:S-carboxamido-papain; C028596:S-carboxymethyl-papain; D010206:Papain; D004229:Dithiothreitol |
Improvements in sexual quality of life after moderate weight loss. | We evaluated changes in sexual quality of life as they relate to weight loss over a 2-year period in individuals undergoing weight loss treatment. Six dimensions of sexual quality of life were measured using items from the Impact of Weight on Quality of Life questionnaire (feeling sexually unattractive, lacking sexual ... | 10.1038/ijir.2008.32 | 18,596,703 | D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012725:Sexual Behavior; D011795:Surveys and Questionnaires; D015431:Weight Loss | International journal of impotence research | 2,008 | |
Vaccinia virions deficient in transcription enzymes lack a nucleocapsid. | The poxvirus virion contains an inner tubular nucleocapsid structure. The nucleocapsid is apparently labile to conventional electron microscopy fixation procedures and has therefore been largely ignored for decades. Advancements in electron microscopy sample preparation, notably high pressure freezing, better preserve ... | 22,944,110 | D000818:Animals; D002460:Cell Line; D020285:Cryoelectron Microscopy; D006801:Humans; D019251:Nucleocapsid; D014158:Transcription, Genetic; D014616:Vaccinia virus; D014764:Viral Proteins; D014771:Virion | Virology | 2,012 | D014764:Viral Proteins | |
Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences. | The technique of DNAase I footprinting has been used to investigate preferred binding sites for echinomycin on a 160-base-pair DNA fragment from E. coli containing the tyr T promoter sequence. Six binding sites have been precisely located in the sequence; a seventh has been partially identified. The minimum site-size i... | 10.1093/nar/12.12.4865 | 6,204,275 | D001482:Base Composition; D001483:Base Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D004269:DNA, Bacterial; D003850:Deoxyribonuclease I; D004448:Echinomycin; D004706:Endodeoxyribonucleases; D004926:Escherichia coli; D011810:Quinoxalines; D012194:RNA-Directed DNA Polymerase | Nucleic acids research | 1,984 | D004269:DNA, Bacterial; D011810:Quinoxalines; D004448:Echinomycin; D012194:RNA-Directed DNA Polymerase; D004706:Endodeoxyribonucleases; D003850:Deoxyribonuclease I; C019329:deoxyribonuclease II |
The effect of heated humidifier in the prevention of intra-operative hypothermia. | Unintentional hypothermia is common in patients undergoing "routine anesthesia in surgery". The aims of the study were to estimate the difference of changes of body temperature during abdominal and limb operations and to evaluate the effectiveness of the heated humidifier for reducing intraoperative heat loss. Forty-th... | 8,031,400 | D000328:Adult; D005260:Female; D006358:Hot Temperature; D006801:Humans; D006813:Humidity; D007035:Hypothermia; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged | Acta anaesthesiologica Sinica | 1,994 | ||
Relationship between clinical presentation and visual outcome in postoperative and posttraumatic endophthalmitis in south central India. | PURPOSE
To determine risk factors for poor visual outcome in postoperative and posttraumatic endophthalmitis in a large referral center in south central India.
METHODS
In this prospective observational series the authors examined 388 patients of postoperative (n= 206) and posttraumatic (n= 182) endophthalmitis at the... | 10.4103/0301-4738.15298 | 15,829,741 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D009877:Endophthalmitis; D005131:Eye Injuries; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013508:Ophthalmologic Surgical Procedures;... | Indian journal of ophthalmology | 2,005 | |
Indications, complications, and mortality rate following craniotomy or craniectomy in dogs and cats: 165 cases (1995-2016). | OBJECTIVE
To determine the most common indications for cranial surgery and identify risk factors associated with the occurrence of complications and death in the perioperative period following cranial surgery.
ANIMALS
150 dogs and 15 cats.
PROCEDURES
For this multi-institutional retrospective case series, medical r... | 10.2460/javma.21.04.0189 | 35,417,413 | D000740:Anemia; D000818:Animals; D002371:Cat Diseases; D002415:Cats; D003399:Craniotomy; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D008297:Male; D008577:Meningeal Neoplasms; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures; D016896:Treatment Outcome | Journal of the American Veterinary Medical Association | 2,022 | |
Correlation between bacterial indicators and bacteriophages in sewage and sludge. | The use of bacteriophages as potential indicators of faecal pollution has recently been studied. The correlation of the number of bacterial indicators and the presence of three groups of bacteriophages, namely somatic coliphages (SOMCPH), F-RNA-specific phages (FRNAPH) and phages of Bacteroides fragilis (BFRPH), in raw... | 10.1111/j.1574-6968.2006.00414.x | 16,958,859 | D001435:Bacteriophages; D003090:Coliphages; D015169:Colony Count, Microbial; D004755:Enterobacteriaceae; D016983:Enterococcus; D004784:Environmental Monitoring; D004926:Escherichia coli; D005243:Feces; D006115:Greece; D012722:Sewage; D010948:Viral Plaque Assay; D014871:Water Microbiology | FEMS microbiology letters | 2,006 | D012722:Sewage |
Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells. | The aim of the present work was to examine the role of muscarinic acetylcholine receptors (mAChRs) on apoptosis in human skin fibroblast cells. Neonatal human skin fibroblast cultures were stimulated with pilocarpine in the presence or absence of specific antagonists. Pilocarpine stimulates apoptosis, total inositol ph... | 10.1002/jcp.21981 | 19,927,300 | D017209:Apoptosis; D002118:Calcium; D002147:Calmodulin; D053148:Caspase 3; D049109:Cell Proliferation; D002478:Cells, Cultured; D053938:DNA Fragmentation; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts; D006801:Humans; D006868:Hydrolysis; D020287:In Situ Nick-End Labeling; D007231:Infant, Newborn; D00729... | Journal of cellular physiology | 2,010 | C086088:CHRM1 protein, human; D002147:Calmodulin; D007295:Inositol Phosphates; D018721:Muscarinic Agonists; D018727:Muscarinic Antagonists; D043643:Receptor, Muscarinic M1; D043587:Receptor, Muscarinic M3; D011976:Receptors, Muscarinic; D010862:Pilocarpine; D048031:JNK Mitogen-Activated Protein Kinases; D010738:Type C ... |
Highly enantioselective synthesis of alpha,beta-diaminopropanoic acid derivatives using a catalytic asymmetric hydrogenation approach. | Rh-DuPhos-catalyzed asymmetric hydrogenation of alpha,beta-diamidoacrylates provides a highly efficient and enantioselective route to chiral alpha,beta-diaminopropanoic acid derivatives. The mechanistic course of the hydrogenation was studied using isotopically enriched enamide complexes and phosphorus and carbon NMR. ... | 10.1021/jo001151n | 11,397,145 | The Journal of organic chemistry | 2,001 | ||
Detection of Invasive Borrelia burgdorferi Strains in North-Eastern Piedmont, Italy. | Following reports of human cases of Lyme borreliosis from the Ossola Valley, a mountainous area of Piemonte, north-western Italy, the abundance and altitudinal distribution of ticks, and infection of these vectors with Borrelia burgdorferi sensu lato were evaluated. A total of 1662 host-seeking Ixodes ricinus were coll... | 10.1111/zph.12156 | 25,220,838 | D000818:Animals; D025065:Borrelia burgdorferi; D007558:Italy; D008969:Molecular Sequence Data; D013987:Ticks | Zoonoses and public health | 2,015 | |
[Study and analysis on the quantitive detection of EBV-DNA in adenoidal hypertrophic and tonsillitis tissues of children]. | OBJECTIVE
To investigate the epidemiology of EBV in adenoidal hypertrophy and chronic tonsillitis and discuss the affection of EBV on the nosogenesis of adenoidal hypertrophy and tonsillitis of children.
METHOD
Fifty-two children with chronic tonsillitis and/or adenoidal hypertrophy had the operations of the tonsille... | 20,359,084 | D000234:Adenoids; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral; D020031:Epstein-Barr Virus Infections; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D006984:Hypertrophy; D008297:Male; D014066:Palatine Tonsil; D014069:Tonsillitis | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | 2,009 | D004279:DNA, Viral | |
Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine. | Inflammatory mediators have been studied in migraine pathophysiology; however, their role is not yet well established. The aim of the present study was to investigate interictal chemokine levels and its association with clinical parameters and psychiatric comorbidities in migraine patients compared with controls. This ... | 10.1007/s10072-014-1931-1 | 25,190,547 | D001007:Anxiety; D001774:Blood Chemical Analysis; D054405:Chemokine CCL3; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders; D011569:Psy... | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2,015 | C515429:CCL3 protein, human; C508606:CXCL8 protein, human; D054405:Chemokine CCL3; D016209:Interleukin-8 |
Asymmetry and Explanations. | In Colless' (1995,Syst. Biol. 44, 102-108) results, cladograms for randomly generated matrices were strongly asymmetrical, and he used this to maintain that real cladograms provide little evidence on asymmetry of phylogeny. His position, however, depended on retaining poorly supported groups as if they were well-suppor... | 10.1111/j.1096-0031.1998.tb00329.x | 34,902,926 | Cladistics : the international journal of the Willi Hennig Society | 1,998 | ||
[The efficacy of the PRIDE educational protocol in facilitating metabolic control in an adult with pre-diabetes]. | Blood pressure, total cholesterol, triglyceride, and BMI in pre-diabetes cases are all higher than in persons with normal blood sugar. Such cases can be said to be in an intermediate stage of development between normal blood sugar and diabetes. If we can offer proper intervention in this period, it can delay or prevent... | 18,836,982 | D015438:Health Behavior; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D011236:Prediabetic State | Hu li za zhi The journal of nursing | 2,008 | ||
Intraarticular anatomic risks of tibial nailing. | OBJECTIVE
To identify the risks to intraarticular structures of the knee during tibial portal creation and to identify the safe zone for tibial nail placement.
STUDY DESIGN
Cadaveric anatomic.
LOCATION
University trauma center.
METHODS
Forty fresh frozen cadaveric knees were studied to elaborate the risks of tibi... | 10.1097/00005131-199905000-00004 | 10,342,349 | D001858:Bone Nails; D002102:Cadaver; D005593:Fracture Fixation, Internal; D006801:Humans; D007719:Knee Joint; D013978:Tibial Fractures | Journal of orthopaedic trauma | 1,999 | |
Fair reliability of eckardt scores in achalasia and non-achalasia patients: Psychometric properties of the eckardt spanish version in a multicentric study. | BACKGROUND
Eckardt symptom score (ESS) is the most used tool for the evaluation of esophageal symptoms. Recent data suggest that it might have suboptimal reliability and validity. The aims of this study were as follows: (a) Develop and validate an international Spanish ESS version. (b) Perform psychometric ESS evaluati... | 10.1111/nmo.13827 | 32,100,424 | D003680:Deglutition Disorders; D003697:Delphi Technique; D004931:Esophageal Achalasia; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires | Neurogastroenterology and motility | 2,020 | |
Roll-over test. | One hundred randomly selected nulliparous, normotensive women were subjected to the roll-over test between 28 and 32 weeks' gestation. Twenty-five women had a positive test. Thirteen of those 25 women developed pre-eclampsia requiring magnesium sulfate therapy. Eight had transient hypertension during labor requiring no... | 10.1016/0002-9378(77)90362-3 | 842,590 | D001794:Blood Pressure; D005260:Female; D006801:Humans; D011187:Posture; D011225:Pre-Eclampsia; D011247:Pregnancy | American journal of obstetrics and gynecology | 1,977 | |
Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F2 alpha injected into conscious mice. | In order to investigate the involvement of glutamate receptor systems in allodynia induced by prostaglandin (PG) E2 or F2 alpha, we co-administered antagonists for N-methyl-D-aspartate (NMDA), non-NMDA, or metabotropic glutamate receptors intrathecally with PGE2 or PGF2 alpha and examined their effects on the allodynia... | 10.1016/0304-3959(94)90227-5 | 7,916,453 | D000818:Animals; D015237:Dinoprost; D015232:Dinoprostone; D005971:Glutamates; D018698:Glutamic Acid; D007278:Injections, Spinal; D051379:Mice; D018377:Neurotransmitter Agents; D010146:Pain; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D013116:Spinal Cord; D009435:Synaptic Transmis... | Pain | 1,994 | D005971:Glutamates; D018377:Neurotransmitter Agents; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D015237:Dinoprost; D015232:Dinoprostone |
Characterization of the parasite-host cell interactions involved in Theileria parva sporozoite invasion of bovine lymphocytes. | Sporozoite invasion of bovine lymphocytes by Theileria parva is a pH-dependent process that occurs without the need for de novo protein synthesis. The process was inhibited by RGD(S) peptides, fibronectin and, in the presence of serum, by antibodies reactive with fibronectin. Invasion was also blocked by a range of sul... | 10.1017/s0031182000082032 | 8,811,851 | D000818:Animals; D000911:Antibodies, Monoclonal; D002417:Cattle; D002478:Cells, Cultured; D003513:Cycloheximide; D004229:Dithiothreitol; D004549:Elastin; D019286:Endopeptidase K; D005033:Ethylmaleimide; D006026:Glycoside Hydrolases; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008214:Lymphocytes; D010455:Peptid... | Parasitology | 1,996 | D000911:Antibodies, Monoclonal; D010455:Peptides; D011134:Polysaccharides; D011500:Protein Synthesis Inhibitors; D011951:Receptors, Complement; D000509:alpha-Fetoproteins; D004549:Elastin; D003513:Cycloheximide; D010741:Phospholipases A; D010738:Type C Phospholipases; D006026:Glycoside Hydrolases; C020668:glycanase; D0... |
A rare protein fluorescence behavior where the emission is dominated by tyrosine: case of the 33-kDa protein from spinach photosystem II. | An abnormal fluorescence emission of protein was observed in the 33-kDa protein which is one component of the three extrinsic proteins in spinach photosystem II particle (PS II). This protein contains one tryptophan and eight tyrosine residues, belonging to a "B type protein". It was found that the 33-kDa protein fluor... | 10.1016/S0006-291X(02)00247-4 | 12,054,643 | D008970:Molecular Weight; D045322:Photosynthetic Reaction Center Complex Proteins; D045332:Photosystem II Protein Complex; D011489:Protein Denaturation; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D018724:Spinacia oleracea; D014364:Tryptophan; D014443:Tyrosine | Biochemical and biophysical research communications | 2,002 | D045322:Photosynthetic Reaction Center Complex Proteins; D045332:Photosystem II Protein Complex; D014443:Tyrosine; D014364:Tryptophan |
[Study on the elements of the fluorescence spectra emitted from ethanol-water mixture]. | The 236 nm UV-light was adopted to excite the 10 ethanol-water mixture samples in which the volume percent of ethanol ranges from 10% to 95%, and the Gaussian decomposition method was used to decompose the fluorescence spectra obtained above to Gaussian curves, where every Gaussian curve can be attributed to the fluore... | 20,672,619 | Guang pu xue yu guang pu fen xi = Guang pu | 2,010 | |||
Central neurological complications in critically ill patients with malignancies. | OBJECTIVE
To determine outcomes in critically ill patients hospitalized in the ICU for central neurological complications of cancer.
DESIGN AND SETTING
A 7-year retrospective study. SUBJECT AND INTERVENTION: Observational study in 100 critically ill cancer patients with central neurological complications managed usin... | 10.1007/s00134-009-1709-8 | 19,908,028 | D000328:Adult; D000368:Aged; D003128:Coma; D016638:Critical Illness; D004569:Electroencephalography; D005260:Female; D006760:Hospitalization; D006801:Humans; D002534:Hypoxia, Brain; D007362:Intensive Care Units; D008297:Male; D008581:Meningitis; D008875:Middle Aged; D009369:Neoplasms; D012121:Respiration, Artificial; D... | Intensive care medicine | 2,010 | |
Inducible expression of human papillomavirus-16 L1 capsomeres in the plastomes of Nicotiana tabacum: Transplastomic plants develop normal flowers and pollen. | Human papillomavirus type-16 (HPV-16) is the major HPV type involved in causing cervical cancer among women. The disease burden is high in developing and underdeveloped countries. Previously, the constitutive expression of HPV-16 L1 protein led to male sterility in transplastomic tobacco plants. Here, the HPV-16 L1 gen... | 10.1002/bab.2136 | 33,650,709 | D036022:Capsid Proteins; D000431:Ethanol; D005260:Female; D035264:Flowers; D052162:Human papillomavirus 16; D006801:Humans; D008297:Male; D009856:Oncogene Proteins, Viral; D030821:Plants, Genetically Modified; D011058:Pollen; D014026:Nicotiana | Biotechnology and applied biochemistry | 2,022 | D036022:Capsid Proteins; D009856:Oncogene Proteins, Viral; D000431:Ethanol |
Strength of predicted information content in the brain biases decision behavior. | Prediction-for-perception theories suggest that the brain predicts incoming stimuli to facilitate their categorization.1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17 However, it remains unknown what the information contents of these predictions are, which hinders mechanistic explanations. This is because typical approaches ... | 10.1016/j.cub.2023.10.042 | 38,065,096 | Current biology : CB | 2,023 | ||
Differential sperm performance as judged by the zona-free hamster egg penetration test relative to differing sperm penetration techniques. | A prospective study on 61 unselected semen samples from infertile patients was conducted to evaluate the effects of sperm preparation techniques on the outcomes of the zona-free hamster egg penetration test (HEPT) to assess the in-vitro fertilizing capacity of spermatozoa. Each semen sample was divided into two equal p... | 10.1093/oxfordjournals.humrep.a137627 | 1,315,791 | D000818:Animals; D002469:Cell Separation; D006224:Cricetinae; D005260:Female; D005306:Fertilization; D015571:Follicular Fluid; D006801:Humans; D008297:Male; D009865:Oocytes; D011205:Povidone; D012822:Silicon Dioxide; D013075:Sperm Capacitation; D013081:Sperm Motility; D013084:Sperm-Ovum Interactions; D015044:Zona Pellu... | Human reproduction (Oxford, England) | 1,992 | C016039:Percoll; D012822:Silicon Dioxide; D011205:Povidone |
Synthesis of barbituric acid containing nucleotides and their implications for the origin of primitive informational polymers. | Given that all processes in modern biology are encoded and orchestrated by polymers, the origin of informational molecules had to be a crucial and significant step in the origin of life on Earth. An important molecule in this context is RNA that is thought to have allowed the transition from chemistry to biology. Howev... | 10.1039/c6cp00686h | 27,153,469 | Physical chemistry chemical physics : PCCP | 2,016 | ||
Effects of subjective and objective task difficulties for feedback- related brain potentials in social situations: An electroencephalogram study. | In this study, the relationship between two types of feedback task difficulties and feedback-related brain potentials, such as feedback-related negativity (FRN), reward positivity (RewP), and P300, was investigated in social situations where participants performed a task simultaneously by a pair. The electroencephalogr... | 10.1371/journal.pone.0277663 | 36,454,908 | D006801:Humans; D005246:Feedback; D004569:Electroencephalography; D001921:Brain; D012201:Reward; D004644:Emotions | PloS one | 2,022 | |
Resection and graft repair for localized hypertrophic neuropathy. | OBJECTIVES
Formulation of surgical management recommendations for localized hypertrophic mononeuropathy has been difficult because of the infrequency of the lesion, lack of precise pathological diagnosis, and uncertainties regarding its cause. The purpose of this retrospective review of the Louisiana State University (... | 10.1097/00006123-199807000-00051 | 9,657,192 | D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D001132:Arm; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007866:Leg; D008297:Male; D009416:Nerve Regeneration; D010525:Peripheral Nerves; D010523:Peripheral Nervous System Diseases; D011183:Postoperative Com... | Neurosurgery | 1,998 | |
Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides. | Rat prothyrotropin-releasing hormone (pro-TRH) is endoproteolyzed within the regulated secretory pathway of neuroendocrine cells yielding five TRH peptides and seven to nine other unique peptides. Endoproteolysis is performed by two prohormone convertases, PC1 and PC2. Proteolysis of pro-TRH begins in the trans-Golgi n... | 10.1074/jbc.M507193200 | 16,204,236 | D000818:Animals; D000911:Antibodies, Monoclonal; D002460:Cell Line; D017077:Culture Media, Conditioned; D000939:Epitopes; D005998:Glycine; D006056:Golgi Apparatus; D007150:Immunohistochemistry; D047468:Immunoprecipitation; D018613:Microscopy, Confocal; D008957:Models, Genetic; D009154:Mutation; D009490:Neurosecretory S... | The Journal of biological chemistry | 2,005 | D000911:Antibodies, Monoclonal; D017077:Culture Media, Conditioned; D000939:Epitopes; D010455:Peptides; D011498:Protein Precursors; C063596:prepro-thyrotropin-releasing hormone; D013973:Thyrotropin-Releasing Hormone; D045664:Proprotein Convertase 1; D045706:Proprotein Convertase 2; D005998:Glycine |
Circulating Long Noncoding RNA LIPCAR Predicts Heart Failure Outcomes in Patients Without Chronic Kidney Disease. | The plasma levels of long noncoding RNA LIPCAR are elevated in heart failure (HF) patients with reduced ejection fraction and associated with left ventricular remodeling and poor outcomes. We studied whether the presence of chronic kidney disease (CKD), as defined by an estimated glomerular filtration rate value <60mL/... | 10.1161/HYPERTENSIONAHA.118.12261 | 30,686,085 | D000368:Aged; D015415:Biomarkers; D004452:Echocardiography; D005260:Female; D006333:Heart Failure; D006352:Heart Ventricles; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D062085:RNA, Long Noncoding; D051436:Renal Insufficiency, Chronic; D013030:Spain; D013318:Stroke Volume; D020257:Ventricular R... | Hypertension (Dallas, Tex. : 1979) | 2,019 | D015415:Biomarkers; D062085:RNA, Long Noncoding |
Enhancement of chemotherapeutic effects with focused shock waves: extracorporeal shock wave chemotherapy (ESWC). | The effects of shock waves in combination with various anti-cancer agents i.e. Bleomycin (BLM), Cisplatin (CDDP) and 5-fluorouracil (5-FU) on tumor cells suspended in media containing these agents were examined. GCIY cells derived from human gastric cancer and LS 174T and SW480 cells derived from human colon cancers we... | 8,797,042 | D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols; D002945:Cisplatin; D003131:Combined Modality Therapy; D005472:Fluorouracil; D006801:Humans; D008096:Lithotripsy; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured | In vivo (Athens, Greece) | 1,996 | D002945:Cisplatin; D005472:Fluorouracil | |
Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses. | The prevalence of hypogonadism has been found to be increased in certain chronic illnesses, especially diabetes, hypertension and obesity. Recently, the prevalence of hypogonadism in primary care practices mirrored that in our population of men with erectile dysfunction (ED). In this study, the prevalence of hypogonadi... | 10.1038/ijir.2009.46 | 19,798,059 | D000328:Adult; D000368:Aged; D000375:Aging; D000437:Alcoholism; D001249:Asthma; D002318:Cardiovascular Diseases; D002908:Chronic Disease; D003324:Coronary Artery Disease; D007172:Erectile Dysfunction; D006801:Humans; D007006:Hypogonadism; D007986:Luteinizing Hormone; D008297:Male; D008875:Middle Aged; D011863:Radioimmu... | International journal of impotence research | 2,010 | D013739:Testosterone; D007986:Luteinizing Hormone |
Androgen and behavior in the male three-spined stickleback, Gasterosteus aculeatus. II. Castration and 11-ketoandrostenedione effects on courtship and parental care during the nesting cycle. | Courtship declines and ceases while parental care increases in the presence of developing eggs during the nesting cycle of the male three-spined stickleback, Gasterosteus aculeatus. Furthermore, circulating 11-ketotestosterone (11KT) levels are higher during the initial "courtship phase" than during the later "parental... | 10.1006/hbeh.2002.1820 | 12,460,593 | D000728:Androgens; D000736:Androstenes; D000818:Animals; D001522:Behavior, Animal; D003380:Courtship; D004343:Drug Implants; D008297:Male; D009425:Nesting Behavior; D009919:Orchiectomy; D010332:Paternal Behavior; D023701:Smegmamorpha | Hormones and behavior | 2,002 | D000728:Androgens; D000736:Androstenes; D004343:Drug Implants; C011657:adrenosterone |
Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists. | Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in the context of obesity and associated metabolic disorders. Although a first proof-of-concept of its beneficial effects has been established in the context of metabolic syndrome in humans, mechanisms are not yet fully understood. ... | 10.3390/cells10010185 | 33,477,821 | D000328:Adult; D000086102:Akkermansia; D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D063388:Endocannabinoids; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome; D050178:Monoglycerides; D009765:Obesity; D047493:PPAR alpha | Cells | 2,021 | D063388:Endocannabinoids; D050178:Monoglycerides; D047493:PPAR alpha; C000634429:PPARA protein, human |
Common hand and wrist conditions: creation of UK research priorities defined by a James Lind Alliance Priority Setting Partnership. | OBJECTIVE
Prioritisation of important treatment uncertainties for 'Common Conditions Affecting the Hand and Wrist' via a UK-based James Lind Alliance Priority Setting Partnership.
SETTING
This process was funded by a national charitable organisation and based in the UK.
PARTICIPANTS
Anyone with experience of common... | 10.1136/bmjopen-2020-044207 | 33,771,825 | D000328:Adult; D035843:Biomedical Research; D006292:Health Priorities; D006801:Humans; D011795:Surveys and Questionnaires; D006113:United Kingdom; D014953:Wrist | BMJ open | 2,021 | |
Design, synthesis and anticancer evaluation of novel arylhydrazones of active methylene compounds. | Nerve growth factor (NGF) and its receptor, tropomyosin kinase receptor kinase type A (TrkA) is emerging as an important target for Glioblastoma (GBM) treatment. TrkA is the cancer biomarker majorly involved in tumor invasion and migration into nearby normal tissue. However, currently, available Trk inhibitors exhibit ... | 10.1016/j.ijbiomac.2023.127909 | 37,951,450 | International journal of biological macromolecules | 2,023 | ||
Outpatient laparoscopic cholecystectomy: what predicts the need for admission? | Laparoscopic cholecystectomy (LC) is commonly performed as an outpatient (OP) procedure in selected patients, either in ambulatory surgery units associated with a hospital or in freestanding facilities. To identify factors that may preclude OPLC, a retrospective analysis of all patients who underwent LC by two surgeons... | 10,366,206 | D000208:Acute Disease; D000328:Adult; D000556:Ambulatory Surgical Procedures; D017081:Cholecystectomy, Laparoscopic; D002764:Cholecystitis; D017558:Elective Surgical Procedures; D004630:Emergencies; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis; D012189... | The American surgeon | 1,999 | ||
Simultaneous Conversion of C5 and C6 Sugars into Methyl Levulinate with the Addition of 1,3,5-Trioxane. | The simultaneous conversion of C5 and C6 mixed sugars into methyl levulinate (MLE) has emerged as a versatile strategy to eliminate costly separation steps. However, the traditional upgrading of C5 sugars into MLE is very complex as it requires both acid-catalyzed and hydrogenation processes. This study concerns the de... | 10.1002/cssc.201902096 | 31,419,072 | ChemSusChem | 2,019 | ||
Intracranial Meningiomas: A Systematic Analysis of Prognostic Factors for Recurrence in a Large Single Institution Surgical Series. | BACKGROUND
Meningioma is the most common primary intracranial tumor. Surgical resection is the first choice of treatment, whereas the role of adjuvant radiotherapy (RT) is still unclear. Aim of the study was to evaluate prognostic factors influencing the local recurrence rate.
METHODS
Patients who had grade I-II meni... | 10.1016/j.wneu.2018.11.150 | 30,496,926 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms; D008579:Meningioma; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D000077982:Progression-Free Survival; D012189:Retrospective Studies; D055... | World neurosurgery | 2,019 | |
Melperone in the treatment of iatrogenic psychosis in Parkinson's disease. | The pharmacological management of Parkinson's disease (PD) can be complicated by psychiatric disorders induced by antiparkinsonian drugs. The reduction or withdrawal of levodopa (l-dopa) and other drugs commonly used in the treatment of PD may attenuate the psychosis but exacerbate motor impairment and disability. Melp... | 8,934,152 | D000368:Aged; D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D002090:Butyrophenones; D005260:Female; D006801:Humans; D007980:Levodopa; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease; D011605:Psychoses, Substance-Induced; D016896:Treatment Outcome | Functional neurology | 1,996 | D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D002090:Butyrophenones; D007980:Levodopa; C008522:metylperon | |
Clonal Background, Resistance Gene Profile, and Porin Gene Mutations Modulate In Vitro Susceptibility to Imipenem-Relebactam in Diverse Enterobacteriaceae. | Treatment options for carbapenem-resistant Enterobacteriaceae (CRE) are limited. While Klebsiella pneumoniae strains harboring blaKPC account for most CRE, recent evidence points to increasing diversification of CRE. We determined whether the CRE species and antibiotic resistance genotype influence the response to rele... | 10.1128/AAC.00573-18 | 29,891,602 | D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D001426:Bacterial Proteins; D004755:Enterobacteriaceae; D015378:Imipenem; D007711:Klebsiella pneumoniae; D008826:Microbial Sensitivity Tests; D009154:Mutation | Antimicrobial agents and chemotherapy | 2,018 | D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D001426:Bacterial Proteins; D015378:Imipenem; C568736:relebactam |
Telemedicine: Is It a Tool for Orthopedics? | PURPOSE OF REVIEW
The purpose of this paper is to illustrate how telemedicine can be beneficial in many areas of orthopedic clinical practice through a literature narrative review. In addition, we discuss advantages, barriers, and enablers of such technology.
RECENT FINDINGS
Telemedicine in orthopedics was initially ... | 10.1007/s12178-020-09680-6 | 33,119,841 | Current reviews in musculoskeletal medicine | 2,020 | ||
Sexual Dysfunction in Inflammatory Bowel Disease: What the Specialist Should Know and Ask. | Inflammatory bowel disease (IBD) is a chronic condition that globally affects the health of people who suffer from it, deteriorating their quality of life (QoL). An aspect rarely explored by healthcare providers is the influence of the disease on the sexual functioning of individuals. This discretion is mainly due to a... | 10.2147/IJGM.S308214 | 34,079,340 | International journal of general medicine | 2,021 | ||
[Experience with functional insulin therapy: metabolic follow up and patient cooperation]. | Functional insulin substitution, an insulin regimen made up of two daily injections of intermedier acting insulin and prandial boluses of regular insulin, was to be introduced in 49 type 1 diabetic patients, as previous regimens consisting of two or three daily injections proved to be inefficient due to the patients' l... | 1,923,467 | D000328:Adult; D003922:Diabetes Mellitus, Type 1; D005260:Female; D006801:Humans; D007328:Insulin; D007332:Insulin Infusion Systems; D008297:Male; D010349:Patient Compliance | Orvosi hetilap | 1,991 | D007328:Insulin | |
Enhancement of octacalcium phosphate deposition on a titanium surface activated by electron cyclotron resonance plasma oxidation. | The present study was designed to investigate whether the formation of octacalcium phosphate (OCP) is accelerated on titanium (Ti) surface by an electron cyclotron resonance (ECR) plasma oxidation at various pressures and temperatures. X-ray diffraction (XRD) of Ti-oxidized substrates showed that the rutile TiO(2) phas... | 10.1002/jbm.b.31605 | 20,166,123 | D001861:Bone Regeneration; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D017357:Cyclotrons; D006358:Hot Temperature; D010084:Oxidation-Reduction; D013997:Time Factors; D014025:Titanium | Journal of biomedical materials research. Part B, Applied biomaterials | 2,010 | D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C022045:octacalcium phosphate; C009495:titanium dioxide; D014025:Titanium |
In vitro availability of iron and zinc: effects of the type, concentration and fractions of digestion products of the protein. | An in vitro dialysis method was employed to determine the effect on the Fe and Zn absorption of the type (beef, pork and soyabean) and the amount (10 and 30 g/kg) of protein present. In addition, the effects of low- and high-molecular-weight (LMW and HMW respectively) digestion products were investigated. After in vitr... | 10.1079/bjn19960079 | 8,958,006 | D000818:Animals; D001682:Biological Availability; D003956:Dialysis; D004044:Dietary Proteins; D004063:Digestion; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007501:Iron; D013025:Glycine max; D013552:Swine; D015032:Zinc | The British journal of nutrition | 1,996 | D004044:Dietary Proteins; D007501:Iron; D015032:Zinc |
Colloidal Self-Assembled Patterns Maintain the Pluripotency and Promote the Hemopoietic Potential of Human Embryonic Stem Cells. | The generation of blood cells in a significant amount for clinical uses is still challenging. Human pluripotent stem cells-derived hemopoietic cells (hPSC-HCs) are a promising cell source to generate blood cells. Previously, it has been shown that the attached substrates are crucial in the maintenance or differentiatio... | 10.3389/fcell.2021.771773 | 34,869,369 | Frontiers in cell and developmental biology | 2,021 | ||
[Primary resection in occlusions caused by cancer of the left colon]. | Based on a survey of 47 cases of left colonic occlusive cancer operated on at the Emergency Surgery Department-University of Rome "La Sapienza", the authors concluded that in such condition, when the patient is not seriously ill, the Hartmann procedure is a valid alternative to the anastomosis-resection because: a) it ... | 2,518,311 | D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction; D008297:Male; D008875:Middle Aged | Il Giornale di chirurgia | 1,989 | ||
[Choice of the surgical method in gastric cysts]. | Operations for gastric cysts were carried out on 8 patients (4 males and 4 females whose ages ranged from 33 to 65 years). Three patients had true cysts, 2 had inflammatory cysts; there were one case of neoplastic, one of retention and one of hydatid cyst. Organ-preserving operative interventions (enucleation, cystecto... | 1,474,784 | D000328:Adult; D000368:Aged; D003560:Cysts; D003937:Diagnosis, Differential; D004443:Echinococcosis; D004724:Endoscopy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D013272:Stomach Diseases; D013274:Stomach Neoplasms | Khirurgiia | 1,992 | ||
Distinct properties and metabolic mechanisms of postresuscitation myocardial injuries in ventricular fibrillation cardiac arrest versus asphyxiation cardiac arrest in a porcine model. | BACKGROUND
The two most prevalent causes of sudden cardiac death are ventricular fibrillation cardiac arrest (VFCA) and asphyxiation cardiac arrest (ACA). Profound postresuscitation myocardial dysfunction has been demonstrated in both VFCA and ACA animal models. Our study aimed to characterize the two porcine models of... | 25,043,088 | D000818:Animals; D001237:Asphyxia; D009202:Cardiomyopathies; D016887:Cardiopulmonary Resuscitation; D004195:Disease Models, Animal; D005260:Female; D006323:Heart Arrest; D006335:Heart Injuries; D008297:Male; D013552:Swine; D014693:Ventricular Fibrillation | Chinese medical journal | 2,014 | ||
Capability, Opportunity, Motivation, and Behaviour (COM-B) model association with Egyptian dentists' reporting of suspected abuse. | BACKGROUND AND OBJECTIVES
This study assessed the frequency of reporting suspected abuse by Egyptian dentists who have examined patients with manifestations of abuse and factors associated with this reporting within the framework of the Capability, Opportunity, Motivation, and Behaviour (COM-B) model.
METHODS
A cross... | 10.1186/s12903-022-02094-5 | 35,246,088 | D000328:Adult; D001291:Attitude of Health Personnel; D002648:Child; D002649:Child Abuse; D003430:Cross-Sectional Studies; D003815:Dentists; D004534:Egypt; D006801:Humans; D009042:Motivation; D011795:Surveys and Questionnaires | BMC oral health | 2,022 | |
Cyclooxygenase-2 inhibition decreases primary and metastatic tumor burden in a murine model of orthotopic lung adenocarcinoma. | OBJECTIVE
To assess cyclooxygenase-2 inhibition on primary tumor and mediastinal metastases in a murine model of orthotopic lung adenocarcinoma.
METHODS
Human lung adenocarcinoma cells (CRL5908, female nonsmoker with cyclooxygenase-2 expression by Western blot) were implanted under direct visualization through the pa... | 10.1016/s0022-5223(03)00790-6 | 14,566,258 | D000230:Adenocarcinoma; D000818:Animals; D000068579:Celecoxib; D045744:Cell Line, Tumor; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008175:Lung Neoplas... | The Journal of thoracic and cardiovascular surgery | 2,003 | D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D011720:Pyrazoles; D013449:Sulfonamides; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D000068579:Celecoxib |
Variations in KIR genes: a study in HIV-1 serodiscordant couples. | BACKGROUND
NK cells have anti-HIV activity mediated through killer cell immunoglobulin-like receptors (KIRs). The current prospective cohort study evaluated whether variation in KIR genes is associated with HIV infection in discordant couples (DCs), where one spouse remains seronegative (HSN) despite repeated exposure ... | 10.1155/2014/891402 | 24,877,146 | D000328:Adult; D018791:CD4 Lymphocyte Count; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections; D015497:HIV-1; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D054340:Receptors, KIR; D019562:Viral Load | BioMed research international | 2,014 | D054340:Receptors, KIR |
Discussion forums for expectant fathers: the perspectives of male educators. | This article describes the perspectives of men recruited to be educators and to facilitate all-male discussion forums for expectant fathers within antenatal education programs. The 8 participants indicated their general satisfaction with the recruitment process and the preparation for and support of the role. They also... | 10.1624/105812408X324525 | 19,436,411 | The Journal of perinatal education | 2,008 | ||
Accurate DNA fragment sizing by capillary electrophoresis with laser-induced fluorescence array for detection of sequence specificity of DNA damage. | Cancer has been linked to mutations within specific codons in genes that code for critical biomolecules such as tumor suppressor proteins (e.g., p53). Activated metabolites like benzo[a]pyrenediol epoxide act on preferred nucleotide sequences of DNA, and such mutations have been identified in cancers. DNA reaction site... | 10.1021/ac702265b | 18,266,391 | D001483:Base Sequence; D004247:DNA; D018736:DNA Adducts; D004249:DNA Damage; D019075:Electrophoresis, Capillary; D005453:Fluorescence; D006801:Humans; D007834:Lasers; D008969:Molecular Sequence Data; D011687:Purines; D012015:Reference Standards | Analytical chemistry | 2,008 | D018736:DNA Adducts; D011687:Purines; D004247:DNA |
Local Immune Biomarker Expression Depending on the Uterine Microbiota in Patients with Idiopathic Infertility. | The endometrium has traditionally been considered sterile. Nowadays, active studies are performed on the female upper genital tract microbiota. Bacteria and/or viruses colonizing the endometrium are known to alter its functional properties, including receptivity and embryo implantation. Uterine cavity inflammation caus... | 10.3390/ijms24087572 | 37,108,732 | D006801:Humans; D005260:Female; D000328:Adult; D014599:Uterus; D007246:Infertility; D004717:Endometrium; D010064:Embryo Implantation; D014591:Uterine Diseases; D016207:Cytokines; D064307:Microbiota; D007247:Infertility, Female | International journal of molecular sciences | 2,023 | D016207:Cytokines |
A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. | We have generated the first mouse model of fibro-blast growth factor receptor 3 (Fgfr3) with the K644E mutation, which accurately reflects the embryonic onset of a neonatal lethal dwarfism, thanatophoric dysplasia type II (TDII). Long-bone abnormalities were identified as early as embryonic day 14, during initiation of... | 10.1093/hmg/9.11.1603 | 10,861,287 | D019943:Amino Acid Substitution; D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation; D002455:Cell Division; D019902:Chondrocytes; D004622:Embryo, Mammalian; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006132:Growth Plate; D017403:In Situ Hybridization; D047908:Intracellular ... | Human molecular genetics | 2,000 | D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; C000606240:Ptch1 protein, mouse; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; C496366:Fgfr3 protein, mouse; D011505:Prot... |
Regulation of egg quality and lipids metabolism by Zinc Oxide Nanoparticles. | This investigation was designed to explore the effects of Zinc Oxide Nanoparticles (ZnO NP) on egg quality and the mechanism of decreasing of yolk lipids. Different concentration of ZnO NP and ZnSO4 were used to treat hens for 24 weeks. The body weight and egg laying frequency were recorded and analyzed. Albumen height... | 10.3382/ps/pev436 | 26,908,885 | D000821:Animal Feed; D000818:Animals; D002645:Chickens; D004032:Diet; D005260:Female; D050356:Lipid Metabolism; D053768:Metal Nanoparticles; D010063:Ovum; D015034:Zinc Oxide | Poultry science | 2,016 | D015034:Zinc Oxide |
Increasing Working Memory Load Reduces Processing of Cross-Modal Task-Irrelevant Stimuli Even after Controlling for Task Difficulty and Executive Capacity. | The classic account of the load theory (LT) of attention suggests that increasing cognitive load leads to greater processing of task-irrelevant stimuli due to competition for limited executive resource that reduces the ability to actively maintain current processing priorities. Studies testing this hypothesis have yiel... | 10.3389/fnhum.2016.00380 | 27,536,226 | Frontiers in human neuroscience | 2,016 | ||
Interrogating the Interplay between Hydrogen and Halogen Bonding in Graphitic Carbon Nitride Building Blocks. | Two graphitic carbon nitride (g-C3N4) molecular building blocks designed for halogen bond driven assembly are evaluated through computational quantum chemistry. Unlike those typically reported in the literature, these g-C3N4-based acceptors each offer three unique sites for halogen bond formation, which when introduced... | 10.1021/acs.jpca.0c09154 | 33,307,681 | The journal of physical chemistry. A | 2,020 | ||
Agronomic performance and food safety of strawberry cultivated on a remediated sediment. | A marine sediment phytoremediated and homogenized by landfarming was tested for its potential recycle as growing media in horticulture. Two strawberry cultivars, Camarosa and Monterey, were grown on remediated sediment alone (TS100), commercial peat/pumice based growing medium (TS0) and a mixture 1:1 in volume of sedim... | 10.1016/j.scitotenv.2021.148803 | 34,265,608 | D059022:Food Safety; D031985:Fragaria; D019015:Geologic Sediments; D006801:Humans; D012987:Soil; D012989:Soil Pollutants | The Science of the total environment | 2,021 | D012987:Soil; D012989:Soil Pollutants |
Status epilepticus after cranial CT with contrast media. | This case illustrates intravenous radiographic contrast material as an unusual and little known etiology of seizure. A brief review of the literature is provided in which the incidence of contrast induced seizures and the potential risk factors for their development are discussed. | 9,401,449 | D000368:Aged; D001254:Astrocytoma; D001932:Brain Neoplasms; D003287:Contrast Media; D006801:Humans; D008297:Male; D013226:Status Epilepticus; D014057:Tomography, X-Ray Computed | WMJ : official publication of the State Medical Society of Wisconsin | 1,997 | D003287:Contrast Media | |
Post-bullous milia. | A 65-year-old woman with bullous pemphigoid responded rapidly to treatment with systemic and topical corticosteroids, but subsequently developed multiple milia where the bullae had been. | 10.1111/j.1440-0960.1996.tb01037.x | 8,771,872 | D000305:Adrenal Cortex Hormones; D000368:Aged; D004814:Epidermal Cyst; D005260:Female; D006801:Humans; D010391:Pemphigoid, Bullous; D012871:Skin Diseases | The Australasian journal of dermatology | 1,996 | D000305:Adrenal Cortex Hormones |
Electron solvation by polar molecules: the interaction of Na atoms with solid methanol films studied with MIES and density functional theory calculations. | The interaction of Na atoms with CH(3)OH films was studied with metastable impact electron spectroscopy (MIES) under UHV conditions. The films were grown at 90(+/-10) K on tungsten substrates and exposed to Na. Na-induced formation of methoxy (CH(3)O) species takes place, and Na atoms become ionized. At small Na exposu... | 10.1063/1.1690237 | 15,267,799 | The Journal of chemical physics | 2,004 | ||
Polarization factors in the symmetrical case of three-wave diffraction. | Particular results of an unconventional approach to the geometry of multiple diffraction are presented. The scalar relations between polarization components of three waves in the symmetrical case, i.e. when the triplet of diffraction vectors forms an isosceles triangle, are considered. The polarization factors are give... | 10.1107/S0108767304005884 | 15,103,173 | Acta crystallographica. Section A, Foundations of crystallography | 2,004 | ||
Anti-HIV effects of CD4-Pseudomonas exotoxin on human lymphocyte and monocyte/macrophage cell lines. | CD4(178)-PE40 is a recombinant protein consisting of the HIV envelope glycoprotein-binding region of human CD4 linked to active domains of Pseudomonas aeruginosa exotoxin A. The hybrid toxin selectively kills HIV-infected human T-cell lines and protects against HIV spread in mixtures of uninfected and infected cells. W... | 10.1111/j.1749-6632.1990.tb17835.x | 2,078,015 | D036002:ADP Ribose Transferases; D000163:Acquired Immunodeficiency Syndrome; D000998:Antiviral Agents; D001427:Bacterial Toxins; D015704:CD4 Antigens; D002460:Cell Line; D005098:Exotoxins; D015497:HIV-1; D006801:Humans; D000922:Immunotoxins; D007962:Leukocytes; D008214:Lymphocytes; D008264:Macrophages; D009000:Monocyte... | Annals of the New York Academy of Sciences | 1,990 | D000998:Antiviral Agents; D001427:Bacterial Toxins; D015704:CD4 Antigens; C057689:CD4-Pseudomonas toxin; D005098:Exotoxins; D000922:Immunotoxins; D011994:Recombinant Proteins; D037521:Virulence Factors; D036002:ADP Ribose Transferases |
The critical care nurse practitioner: an advanced practice role for the critical care nurse. | Research provides compelling evidence that supports the current and future utilization of critical care nurse practitioners (CCNPs) in pivotal roles as providers of cost-effective, quality patient-centered care for critically ill and technology-dependent adults. This paper gives a historical perspective and describes t... | 10.1097/00003465-199601000-00010 | 8,631,222 | D000328:Adult; D002568:Certification; D003422:Critical Care; D003479:Curriculum; D004511:Education, Nursing, Graduate; D006801:Humans; D007587:Job Description; D009722:Nurse Practitioners | Dimensions of critical care nursing : DCCN | 1,996 | |
Minimally invasive vein harvesting significantly reduces pain and wound morbidity. | OBJECTIVES
Minimally invasive saphenous vein harvesting is advocated to reduce wound morbidity. Our early experience with minimally invasive techniques, however, suggested that increased tissue traction and trauma might follow. We aimed to test the hypothesis that minimally invasive harvesting reduces post-operative pa... | 10.1016/s1010-7940(02)00296-8 | 12,204,728 | D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D010149:Pain, Postoperative; D011446:Prospective Studies; D012501:Saphenous Vein; D013525:Surgical Instruments; D013530:Surgical Wound Infection; D020858:Tissue and Organ Ha... | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery | 2,002 | |
[The transition from work to retirement: Experienced support from adult children]. | BACKGROUND
Retirement is an important life event, which is often characterized by many changes in the lives of individuals. Support from children can potentially help older adults to cope with these changes. Empirical insights on intergenerational support regarding retirement are limited though. To what extent do paren... | 10.1007/s12439-016-0172-6 | 27,098,422 | D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016901:Intergenerational Relations; D008016:Life Change Events; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D010287:Parent-Child Relations; D012179:Retirement; D012944:Social Support | Tijdschrift voor gerontologie en geriatrie | 2,016 | |
Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria. | Exopolysaccharides play an important structural and functional role in the development and maintenance of microbial biofilms. Although the majority of research to date has focused on the exopolysaccharide systems of biofilm-forming bacteria, recent studies have demonstrated that medically relevant fungi such as Candida... | 10.1074/jbc.R116.720995 | 27,129,222 | D000935:Antifungal Agents; D001232:Aspergillus fumigatus; D018441:Biofilms; D002176:Candida albicans; D062610:Fungal Polysaccharides; D005658:Fungi; D054884:Host-Pathogen Interactions; D006801:Humans; D009181:Mycoses; D011135:Polysaccharides, Bacterial | The Journal of biological chemistry | 2,016 | D000935:Antifungal Agents; D062610:Fungal Polysaccharides; D011135:Polysaccharides, Bacterial |
Periviability: A Review of Key Concepts and Management for Perinatal Nursing. | One of the most complex clinical problems in obstetrics and neonatology is caring for pregnant women at the threshold of viability. Births near viability boundaries are grave events that carry a high prevalence of neonatal death or an increased potential for severe lifelong complications and disabilities among those wh... | 10.1097/JPN.0000000000000473 | 32,332,444 | D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D017283:Neonatal Nursing; D009359:Neonatology; D009774:Obstetrics; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D047928:Premature Birth; D015996:Survival Rate | The Journal of perinatal & neonatal nursing | 2,020 | |
Anti-Inflammatory Properties of KLS-13019: a Novel GPR55 Antagonist for Dorsal Root Ganglion and Hippocampal Cultures. | KLS-13019, a novel devised cannabinoid-like compound, was explored for anti-inflammatory actions in dorsal root ganglion cultures relevant to chemotherapy-induced peripheral neuropathy (CIPN). Time course studies with 3 µM paclitaxel indicated > 1.9-fold increases in immunoreactive (IR) area for cell body GPR55 after 3... | 10.1007/s12031-022-02038-2 | 35,779,192 | D000893:Anti-Inflammatory Agents; D002186:Cannabinoids; D005727:Ganglia, Spinal; D006624:Hippocampus; D006801:Humans; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D009437:Neuralgia; D017239:Paclitaxel; D043882:Receptors, Cannabinoid | Journal of molecular neuroscience : MN | 2,022 | D000893:Anti-Inflammatory Agents; D002186:Cannabinoids; C524885:GPR55 protein, human; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D043882:Receptors, Cannabinoid; D017239:Paclitaxel |
Clinical characteristics of ceftriaxone plus metronidazole in complicated intra-abdominal infection. | PURPOSE
Empirical antibiotics in complicated intra-abdominal infection (c-IAI), such as secondary peritonitis are a first step of treatment. Empirical antibiotic regimen is very diverse. Ceftriaxone plus metronidazole regimen (CMR) is one of the empirical antibiotic regimens used in treatment of c-IAI. However, althoug... | 10.4174/astr.2015.89.1.43 | 26,131,444 | Annals of surgical treatment and research | 2,015 |
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