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Paclitaxel combined with harmine inhibits the migration and invasion of gastric cancer cells through downregulation of cyclooxygenase-2 expression. | Cyclooxygenase-2 (COX-2) has a critical role in the invasiveness and metastasis of gastric cancer. In addition, paclitaxel (PTX) and harmine (HM) were reported to be potential therapeutic drug candidates for cancer therapy; however, the synergistic antitumor effect of PTX and HM combined treatment on the human gastric ... | 10.3892/ol.2015.3425 | 26,622,726 | Oncology letters | 2,015 | ||
DSM-IV: work in progress. | The authors present an overview of the work in progress on DSM-IV. After a brief historical review, they discuss the principles and multiple purposes of the DSM-IV effort and outline the three stages of its empirical documentation: systematic literature reviews, analysis of unpublished data, and field trials. Next, the... | 10.1176/ajp.147.11.1439 | 2,221,154 | D006801:Humans; D001523:Mental Disorders; D009626:Terminology as Topic | The American journal of psychiatry | 1,990 | |
Early Postoperative Complications After Shoulder Arthroplasty in Patients With Epilepsy. | Epilepsy is the most common serious neurological disorder in the United States, but little is known about its effect in the perioperative shoulder surgery setting. The authors sought to determine whether patients with epilepsy undergoing shoulder arthroplasty would be at increased risk for in-hospital adverse events, p... | 10.3928/01477447-20160714-02 | 27,458,894 | D058186:Acute Kidney Injury; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia; D000072228:Arthroplasty, Replacement, Shoulder; D001803:Blood Transfusion; D016208:Databases, Factual; D004827:Epilepsy; D005260:Female; D005767:Gastrointestinal Diseases; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:... | Orthopedics | 2,016 | |
Induction and origin of hepatocytes in rat pancreas. | 2-[4(2,2- Dichlorocyclopropyl )phenoxy]2-methyl propionic acid (ciprofibrate), a peroxisome proliferator , induced hepatocytes in the pancreas of adult male F-344 rats when added to their diet at a dosage of 10 mg/kg body weight for 60-72 wk. These cells are morphologically indistinguishable from hepatic hepatocytes an... | 10.1083/jcb.98.6.2082 | 6,202,703 | D000818:Animals; D002994:Clofibrate; D002995:Clofibric Acid; D058607:Fibric Acids; D000960:Hypolipidemic Agents; D008099:Liver; D008297:Male; D008854:Microscopy, Electron; D009928:Organ Specificity; D010179:Pancreas; D051381:Rats; D011916:Rats, Inbred F344; D013194:Staining and Labeling | The Journal of cell biology | 1,984 | D058607:Fibric Acids; D000960:Hypolipidemic Agents; D002995:Clofibric Acid; C019304:ciprofibrate; D002994:Clofibrate |
Interactions and substrate selectivity within the SctRST complex of the type III secretion system of enteropathogenic Escherichia coli. | Many bacterial pathogens employ a protein complex, termed the type III secretion system (T3SS), to inject bacterial effectors into host cells. These effectors manipulate various cellular processes to promote bacterial growth and survival. The T3SS complex adopts a nano-syringe shape that is assembled across the bacteri... | 10.1080/19490976.2021.2013763 | 34,965,187 | D020816:Amino Acid Motifs; D054308:Enteropathogenic Escherichia coli; D029968:Escherichia coli Proteins; D011485:Protein Binding; D000072417:Protein Domains; D000069296:Type III Secretion Systems | Gut microbes | 2,022 | D029968:Escherichia coli Proteins; D000069296:Type III Secretion Systems |
Conservation Decision-Making in Palau: An Example of the Parallel Working of Scientific and Traditional Ecological Knowledge. | Despite unprecedented knowledge of conservation science, loss of biodiversity continues on a global scale. In this study, we investigate how choices are exercised where science, local and traditional knowledge come together for conservation decision-making. Our case study is the Palau Protected Areas Network, a program... | 10.1007/s00267-019-01213-3 | 31,654,108 | D044822:Biodiversity; D003247:Conservation of Natural Resources; D003657:Decision Making; D004463:Ecology; D019029:Palau | Environmental management | 2,019 | |
Vaginal agglutination and hematometra associated with epidermolysis bullosa. | A case of genital involvement with epidermolysis bullosa is described. Scarring led to vaginal obstruction and hematometra. The classification and treatment of this rare disorder are discussed. | 3,808,539 | D000328:Adult; D001284:Atrophy; D003251:Constriction, Pathologic; D004820:Epidermolysis Bullosa; D005260:Female; D006409:Hematometra; D006801:Humans; D014623:Vaginal Diseases; D014844:Vulva | Obstetrics and gynecology | 1,987 | ||
Evidence that human immunoglobulin M rheumatoid factors can Be derived from the natural autoantibody pool and undergo an antigen driven immune response in which somatically mutated rheumatoid factors have lower affinities for immunoglobulin G Fc than their germline counterparts. | The question of whether immunoglobulin (Ig)M rheumatoid factors (RF) arise as the result of an abnormal expansion of already existing clones producing natural autoantibodies or emerge as new clones that are somatically mutated owing to an antigen driven immune response has never been conclusively answered. In this stud... | 10.1046/j.1365-3083.2000.00731.x | 10,736,104 | D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000915:Antibody Affinity; D000917:Antibody Formation; D001172:Arthritis, Rheumatoid; D004797:Enzyme-Linked Immunosorbent Assay; D005803:Genes, Immunoglobulin; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007075:Immunoglobu... | Scandinavian journal of immunology | 2,000 | D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011994:Recombinant Proteins; D012217:Rheumatoid Factor |
Cannabis and its derivatives: review of medical use. | BACKGROUND
Use of cannabis is often an under-reported activity in our society. Despite legal restriction, cannabis is often used to relieve chronic and neuropathic pain, and it carries psychotropic and physical adverse effects with a propensity for addiction. This article aims to update the current knowledge and eviden... | 10.3122/jabfm.2011.04.100280 | 21,737,770 | D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D002186:Cannabinoids; D002188:Cannabis; D004357:Drug Synergism; D006801:Humans; D013287:Illicit Drugs; D002189:Marijuana Abuse; D008385:Marijuana Smoking; D009437:Neuralgia; D010146:Pain; D008517:Phytotherapy; D014481:United States | Journal of the American Board of Family Medicine : JABFM | 2,011 | D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D002186:Cannabinoids; D013287:Illicit Drugs |
The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation. | Protein misfolding, followed by aggregation and amyloid formation is an underlying pathological hallmark in a number of prevalent diseases, including Parkinson's (PD), Alzheimer's (AD) and Type 2 diabetes (T2D). In the case of PD, the aggregation of α-synuclein protein (α-syn) has been shown to be highly cytotoxic and ... | 26,601,760 | D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival; D003603:Cytotoxins; D050883:HSC70 Heat-Shock Proteins; D006801:Humans; D008958:Models, Molecular; D066329:Protein Aggregates; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D051844:alpha-Synuclein | International journal of biological macromolecules | 2,016 | D003603:Cytotoxins; D050883:HSC70 Heat-Shock Proteins; D066329:Protein Aggregates; D051844:alpha-Synuclein | |
Displacement of albumin-bound antimicrobial agents by bilirubin. | The ability of bilirubin to displace antimicrobial agents from their binding sites on albumin was studied in vitro by equilibrium dialysis. Sulfonamides, tetracyclines, penicillins and cephalosporins of different degrees of protein binding were tested. It was found that bilirubin reduced the protein binding of all four... | 10.1159/000136629 | 1,031,216 | D000890:Anti-Infective Agents; D001663:Bilirubin; D001667:Binding, Competitive; D002511:Cephalosporins; D006801:Humans; D010406:Penicillins; D011485:Protein Binding; D012709:Serum Albumin; D013449:Sulfonamides; D013754:Tetracyclines | Pharmacology | 1,976 | D000890:Anti-Infective Agents; D002511:Cephalosporins; D010406:Penicillins; D012709:Serum Albumin; D013449:Sulfonamides; D013754:Tetracyclines; D001663:Bilirubin |
Effect of cholesterol levels on villous histology in colonic adenomas. | To date no studies have examined the relationship between cholesterol levels and the occurrence of specific colonic polyp histologies. Villous histology has a greater predilection for subsequent malignancies than other histologies. Consequently, we examined the effect of cholesterol levels on the occurrence of villous ... | 10.1023/a:1005512805792 | 10,795,751 | D018253:Adenoma, Villous; D000328:Adult; D000368:Aged; D001706:Biopsy; D002784:Cholesterol; D003110:Colonic Neoplasms; D003111:Colonic Polyps; D003113:Colonoscopy; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia; D007413:Intestinal Mucosa; D008297:Male; D008875:Middle Aged; D012307:Risk Factors | Digestive diseases and sciences | 2,000 | D002784:Cholesterol |
High Efficiency Molecular Delivery with Sequential Low-Energy Sonoporation Bursts. | Microbubbles interact with ultrasound to induce transient microscopic pores in the cellular plasma membrane in a highly localized thermo-mechanical process called sonoporation. Theranostic applications of in vitro sonoporation include molecular delivery (e.g., transfection, drug loading and cell labeling), as well as m... | 10.7150/thno.13033 | 26,681,986 | D003911:Dextrans; D016503:Drug Delivery Systems; D004847:Epithelial Cells; D016650:Fluorescein-5-isothiocyanate; D006367:HeLa Cells; D006801:Humans; D045423:Microbubbles; D012235:Rhodamines; D014463:Ultrasonography | Theranostics | 2,015 | D003911:Dextrans; D012235:Rhodamines; C015219:fluorescein isothiocyanate dextran; C009434:tetramethylrhodamine isothiocyanate; D016650:Fluorescein-5-isothiocyanate |
Effect of calcitriol supplementation and tail suspension on serum biomarkers of bone formation in rats. | BACKGROUND
Calcitriol is documented to cause significant increase in bone mass densitometry counteracting osteoporosis. Promising results of calcitriol supplementation in studies aiming space flight induced osteoporosis is little and the effect of this hormone on biomarkers of bone metabolism is not examined yet in spa... | 10.1186/s40200-015-0142-5 | 25,806,360 | Journal of diabetes and metabolic disorders | 2,015 | ||
Regulation of the nuclear orphan receptor Nur77 in bone by parathyroid hormone. | Osteoblasts function under the control of several hormones and growth factors. Among them, parathyroid hormone (PTH) and steroid hormones have significant effects on bone metabolism. We show that PTH induced the expression of Nur77, a member of the NGFI-B subfamily of nuclear orphan receptors in bone. PTH rapidly and t... | 10.1006/bbrc.2001.4459 | 11,237,747 | D000818:Animals; D000831:Animals, Newborn; D015152:Blotting, Northern; D015153:Blotting, Western; D002478:Cells, Cultured; D046508:Culture Techniques; D003513:Cycloheximide; D004268:DNA-Binding Proteins; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation; D051379:Mice; D057105:Nuclear Receptor... | Biochemical and biophysical research communications | 2,001 | D004268:DNA-Binding Proteins; C539818:Nr4a1 protein, mouse; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D010281:Parathyroid Hormone; D011500:Protein Synthesis Inhibitors; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; D003513:C... |
Risk factors for spontaneous preterm delivery after arrested episode of preterm labor. | INTRODUCTION
We aimed to identify specific risk factors for spontaneous preterm delivery (PTD) among women with arrested preterm labor (PTL).
METHOD
A retrospective study of women admitted due to imminent PTL and intact membranes, which did not progress to PTD within 24 h from admission. Eligibility was limited to si... | 10.3109/14767058.2015.1016420 | 25,731,654 | D000328:Adult; D054791:Cervical Length Measurement; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007747:Labor Stage, First; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D047928:Premature Birth; D012189:Retrospective Studies; D012307:Risk Factors; D015145:Tocolysis; D05581... | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | 2,016 | |
The effect of measurement error on the determination of Helicobacter pylori prevalence. | We assessed the effect of serum-based antibody tests on the epidemiology of Helicobacter pylori infection. We took crude population prevalences of H. Pylori infection from existing publications in which antibody-based tests were used to determine prevalence. We then calculated 95% confidence intervals that included ter... | 10.1097/00001648-199703000-00015 | 9,229,216 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003951:Diagnostic Errors; D005260:Female; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D007223:Infant; D... | Epidemiology (Cambridge, Mass.) | 1,997 | D000907:Antibodies, Bacterial |
Cancer as a disease of tissue pattern formation. | The diagnosis of neoplastic disease still lays its foundations on the detection of altered tissue morphology. Most importantly, cancer begins, at least in many cases as a disease with altered tissue pattern formation. It is therefore rather surprising that the issue regarding the possible mechanistic role of such prope... | 22,985,795 | D006801:Humans; D000860:Hypoxia; D009024:Morphogenesis; D009369:Neoplasms; D015398:Signal Transduction; D059016:Tumor Microenvironment | Progress in histochemistry and cytochemistry | 2,012 | ||
Nanoscale View of Dewetting and Coating on Partially Wetted Solids. | There remain significant gaps in our ability to predict dewetting and wetting despite the extensive study over the past century. An important reason is the absence of nanoscopic knowledge about the processes near the moving contact line. This experimental study for the first time obtained the liquid morphology within 1... | 10.1021/acs.jpclett.6b00620 | 27,115,464 | The journal of physical chemistry letters | 2,016 | ||
Comparison of Subcuticular Suture Type for Skin Closure After Cesarean Delivery: A Randomized Controlled Trial. | OBJECTIVE
To compare the rate of wound complications among women who underwent cesarean delivery through a Pfannenstiel skin incision followed by subcuticular closure with either poliglecaprone 25 suture or polyglactin 910 suture.
METHODS
Patients undergoing nonemergent cesarean delivery at or beyond 37 weeks of gest... | 10.1097/AOG.0000000000002200 | 28,796,687 | D000328:Adult; D002585:Cesarean Section; D062109:Dermatologic Surgical Procedures; D004146:Dioxanes; D005260:Female; D006801:Humans; D011091:Polyesters; D011098:Polyglactin 910; D011247:Pregnancy; D011446:Prospective Studies; D013529:Surgical Wound Dehiscence; D013536:Suture Techniques; D013537:Sutures; D016896:Treatme... | Obstetrics and gynecology | 2,017 | D004146:Dioxanes; D011091:Polyesters; D011098:Polyglactin 910; C095495:glycolide E-caprolactone copolymer |
Novel heteroaryl phosphonicdiamides PTPs inhibitors as anti-hyperglycemic agents. | BACKGROUND
Chronic and oral administration of benzylamine improves glucose tolerance. Picolylamine is a selective functional antagonist of the human adenosine A2B receptor. Phosphonic diamide derivatives enhance the cellular permeability and in turn their biological activities.
METHODS
A series of heteroaryl phosphon... | 10.1186/s40199-014-0076-3 | 25,542,373 | D000818:Animals; D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D001812:Blood-Brain Barrier; D018938:Caco-2 Cells; D003921:Diabetes Mellitus, Experimental; D003924:Diabetes Mellitus, Type 2; D004195:Disease Models, Animal; D004285:Dogs; D015195:Drug Design; D004791:Enzyme Inhibitors; D006801:Humans; D... | Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences | 2,014 | D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D017553:Phosphorus Compounds; D017027:Protein Tyrosine Phosphatases |
Oncogenity of BK virus for immunosuppressed hamsters. | Tumors were induced by BK virus (BKV) inoculated intravenously in 3-week-old Syrian golden hamsters immunosuppressed with anti-lymphocyte serum or methylprednisolone acetate alone or in association with gamma-radiation (60Co). The induced neoplasms were ependymoma, carcinoma of pancreatic islets, lymphoma, osteosarcoma... | 10.1007/BF01318078 | 6,293,415 | D000818:Animals; D000914:Antibodies, Viral; D000956:Antigens, Viral; D001739:BK Virus; D006224:Cricetinae; D004279:DNA, Viral; D004806:Ependymoma; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D007680:Kidney Neoplasms; D008223:Lymphoma; D008647:Mesocricetus; D009374:Neoplasms, Experimental; D012516:Osteo... | Archives of virology | 1,982 | D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral |
Use of after action reports (AARs) to promote organizational and systems learning in emergency preparedness. | Many public health and healthcare organizations use formal knowledge management practices to identify and disseminate the experiences gained over time. The "lessons-learned" approach is one such example of knowledge management practice applied to the wider concept of organizational learning. In the field of emergency p... | 10.3390/ijerph9082949 | 23,066,408 | D002959:Civil Defense; D006801:Humans; D033181:Information Dissemination; D007858:Learning; D010043:Outcome and Process Assessment, Health Care | International journal of environmental research and public health | 2,012 | |
High-throughput DFT calculations of formation energy, stability and oxygen vacancy formation energy of ABO3 perovskites. | ABO3 perovskites are oxide materials that are used for a variety of applications such as solid oxide fuel cells, piezo-, ferro-electricity and water splitting. Due to their remarkable stability with respect to cation substitution, new compounds for such applications potentially await discovery. In this work, we present... | 10.1038/sdata.2017.153 | 29,039,848 | Scientific data | 2,017 | ||
Purification and organization of the gene 1 portal protein required for phage P22 DNA packaging. | The gene 1 protein of Salmonella bacteriophage P22 is located at the DNA packaging vertex of the mature particle. The protein is incorporated into the procapsid shell during shell assembly and is required for DNA packaging. The unassembled precursor form of the gene 1 protein has been purified from cells infected with ... | 10.1021/bi00406a009 | 3,288,279 | D002213:Capsid; D004279:DNA, Viral; D005796:Genes; D005814:Genes, Viral; D046911:Macromolecular Substances; D008970:Molecular Weight; D012483:Salmonella Phages; D012486:Salmonella typhimurium; D014764:Viral Proteins | Biochemistry | 1,988 | D004279:DNA, Viral; D046911:Macromolecular Substances; D014764:Viral Proteins |
[Fine tissue studies of the nerve supply to the dental pulp in domestic sheep (O. ammon aries Linné, 1758)]. | The nerve supply of the pulp was investigated in 17 sheep of various breeds and age groups belonging to both sexes, using light and electron microscopy. The following results were obtained: The dental pulp of sheep is supplied with myelinated and unmyelinated nerve fibres. The subodontoblastic plexus of Raschkow, as fo... | 1,796,459 | D000818:Animals; D001369:Axons; D003782:Dental Pulp; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009412:Nerve Fibers; D009804:Odontoblasts; D012756:Sheep | Tierarztliche Praxis | 1,991 | ||
Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs. | OBJECTIVE
To study the effects of platelet activating factor (PAF) antagonism on cardiovascular function in Escherichia coli endotoxaemia in non-hypotensive anaesthetised pigs.
DESIGN
Experimental study.
SETTING
Trauma research unit, Sweden.
MATERIAL
24 Domestic juvenile pigs.
INTERVENTIONS
18 Pigs received a c... | 8,817,228 | D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D019446:Endotoxemia; D004927:Escherichia coli Infections; D006339:Heart Rate; D006439:Hemodynamics; D007930:Leucine; D010972:Platelet Activating Factor; D018805:Sepsis; D013318:Stroke Volume; D013552:Swine | The European journal of surgery = Acta chirurgica | 1,996 | C094498:BB 882; D010972:Platelet Activating Factor; D007930:Leucine | |
Mercury concentrations in commercial fish from freshwater and saltwater. | Research was performed to investigate the concentration of mercury in muscle and liver of fish species from freshwater (Barbus xanthopterus, Barbus grypus, Liza abu) and saltwater (Cynoglossus arel, Periophthalmus waltoni, Otolithes ruber) in Khouzestan, Iran. In freshwater fish, muscle was polluted in comparison with ... | 10.1007/s00128-011-0510-x | 22,210,447 | D000818:Animals; D004781:Environmental Exposure; D005399:Fishes; D005618:Fresh Water; D006801:Humans; D008099:Liver; D008628:Mercury; D009132:Muscles; D018570:Risk Assessment; D012623:Seawater; D014874:Water Pollutants, Chemical | Bulletin of environmental contamination and toxicology | 2,012 | D014874:Water Pollutants, Chemical; D008628:Mercury |
A vascular cause of unexplained exertional wheeze: Keeping a high index of suspicion. | A 31-year-old female was referred with a history of unexplained exertional breathlessness. The patient had normal resting lung function and a CT thorax showed no significant abnormality. Closer scrutiny of the flow-volume loop confirmed an elevated Empey's index. Cardiopulmonary exercise testing with continuous laryngo... | 10.1016/j.rmcr.2019.100993 | 31,908,919 | Respiratory medicine case reports | 2,020 | ||
[Effort, Success and Failure while Seeking for Outpatient Psychotherapy - Results of a Prospective Study]. | OBJECTIVE
Patients and general practitioners often report on difficulties in finding a psychotherapist. In this prospective study, we investigate how much effort patients have to invest and how long it takes until they get an appointment with a psychotherapist.
METHODS
69 patients who were recommended to have psychot... | 10.1055/a-1005-6958 | 31,634,964 | D001071:Appointments and Schedules; D005858:Germany; D006801:Humans; D001523:Mental Disorders; D010045:Outpatients; D011446:Prospective Studies; D011613:Psychotherapy | Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) | 2,021 | |
[Mutagenic and antimutagenic activities of human whole blood, plasma and albumin]. | The seeds of Crepis capillaris were used to examine the mutagenic und antimutagenic properties of human whole blood, plasma, serum albumin and gamma-globulin by recording chromosomal and chromatid aberrations. The antimutagenic activity was determined by preliminary, simultaneous, and subsequent biosubstrate treatments... | 9,324,379 | D016587:Antimutagenic Agents; D001769:Blood; D002869:Chromosome Aberrations; D006801:Humans; D019684:Magnoliopsida; D016296:Mutagenesis; D009153:Mutagens; D010949:Plasma; D012709:Serum Albumin | Vestnik Rossiiskoi akademii meditsinskikh nauk | 1,997 | D016587:Antimutagenic Agents; D009153:Mutagens; D012709:Serum Albumin | |
How Peripheral Vestibular Damage Affects Velocity Storage: a Causative Explanation. | Velocity storage is a centrally-mediated mechanism that processes peripheral vestibular inputs. One prominent aspect of velocity storage is its effect on dynamic responses to yaw rotation. Specifically, when normal human subjects are accelerated to constant angular yaw velocity, horizontal eye movements and perceived a... | 10.1007/s10162-022-00853-3 | 35,768,706 | D001499:Bayes Theorem; D001921:Brain; D005133:Eye Movements; D006801:Humans; D012027:Reflex, Vestibulo-Ocular; D012399:Rotation; D014722:Vestibule, Labyrinth | Journal of the Association for Research in Otolaryngology : JARO | 2,022 | |
Analytical and clinical evaluation of a novel assay for anti-HBc IgG measurement in serum of subjects with overt and occult HBV infection. | OBJECTIVES
We assessed the analytical and clinical performance of the Lumipulse® G HBcAb-N (Fujirebio, Japan) assay for IgG antibodies to hepatitis B core antigen (anti-HBc IgG) measurement in serum of subjects with overt and occult HBV infection (OBI).
MATERIALS/METHODS
Serum anti-HBc IgG was assessed in 181 anti-HB... | 10.1016/j.diagmicrobio.2020.114985 | 32,008,810 | D000328:Adult; D000368:Aged; D000998:Antiviral Agents; D015331:Cohort Studies; D004279:DNA, Viral; D005260:Female; D006509:Hepatitis B; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic; D006801:Humans; D007074:Immunoglobulin G; D007564:Japan; D05... | Diagnostic microbiology and infectious disease | 2,020 | D000998:Antiviral Agents; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D007074:Immunoglobulin G |
Use of Retrospective Continuous Glucose Monitoring Data Is Underrated and Underused. | Access to real-time glucose data in real time allows users to make informed decisions about their insulin dosages, appropriate carbohydrate intake, exercise, and other health behaviors. Programmable alarms and alerts warn users about current and/or impending acute glycemic events. However, the value and utility of retr... | 10.1177/19322968211070837 | 35,043,701 | D006801:Humans; D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1; D012189:Retrospective Studies; D015190:Blood Glucose Self-Monitoring; D007328:Insulin; D007004:Hypoglycemic Agents | Journal of diabetes science and technology | 2,023 | D001786:Blood Glucose; D007328:Insulin; D007004:Hypoglycemic Agents |
Arabidopsis mitochondrial proteomics. | Significant efforts have sought to uncover the protein profile of Arabidopsis mitochondria to act as a model for the mitochondrial proteome from plants. A combination of techniques have been undertaken to achieve this goal. We outline a basic two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) separation of mi... | 10.1007/978-1-59745-365-3_38 | 18,314,751 | D017360:Arabidopsis; D029681:Arabidopsis Proteins; D015180:Electrophoresis, Gel, Two-Dimensional; D007525:Isoelectric Focusing; D013058:Mass Spectrometry; D008928:Mitochondria; D024101:Mitochondrial Proteins; D020543:Proteome; D040901:Proteomics; D014357:Trypsin | Methods in molecular biology (Clifton, N.J.) | 2,007 | D029681:Arabidopsis Proteins; D024101:Mitochondrial Proteins; D020543:Proteome; D014357:Trypsin |
Safety of enteral naloxone for the reversal of opiate-induced constipation in the intensive care unit. | BACKGROUND
Opiates are the mainstay of analgesia in the intensive care unit (ICU). Unfortunately, constipation is a common adverse effect associated with opioid use. Naloxone is a pure opiate antagonist that is frequently utilized in practice for the prophylaxis or treatment of opiate-induced constipation in the ICU. D... | 10.1111/j.1365-2710.2008.00982.x | 19,250,137 | D000368:Aged; D000701:Analgesics, Opioid; D003248:Constipation; D003422:Critical Care; D005260:Female; D005283:Fentanyl; D006801:Humans; D007441:Intubation, Gastrointestinal; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009270:Naloxone; D009292:Narcotic Antagonists; D010146:Pain; D010147:Pain Measu... | Journal of clinical pharmacy and therapeutics | 2,009 | D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009270:Naloxone; D005283:Fentanyl |
Driving Under the Influence of Antidepressants: A Systematic Review and Update of the Evidence of Experimental and Controlled Clinical Studies. | Introduction This review provides an update of experimental and clinical studies on the effects of antidepressants on driving performance. Methods A systematic literature search on the PubMed database (1980-2016) was performed. Results Twenty-eight studies could be included in this review, whereas only 5 studies invest... | 10.1055/s-0043-113572 | 28,718,182 | D000428:Alcohol Drinking; D000928:Antidepressive Agents; D000066448:Driving Under the Influence; D004357:Drug Synergism; D006801:Humans | Pharmacopsychiatry | 2,017 | D000928:Antidepressive Agents |
Drug delivery via porous silicon: a focused patent review. | Although silicon is more commonly associated with computer chips than with drug delivery, with the discovery that porous silicon is a viable biocompatible material, mesoporous silicon with pores between 2 and 50 nm has been loaded with small molecule and biomolecule therapeutics and safely implanted for controlled rele... | 10.4155/ppa-2016-0042 | 28,248,125 | D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D010330:Patents as Topic; D004364:Pharmaceutical Preparations; D016062:Porosity; D012825:Silicon; D054852:Small Molecule Libraries; D013499:Surface Properties | Pharmaceutical patent analyst | 2,017 | D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D054852:Small Molecule Libraries; D012825:Silicon |
[Results of cardiac operation and thoracic aortic operation in patients aged 75 years or older]. | A total of 121 patients aged 75 years or older underwent cardiac operation or thoracic aortic operation at our hospital between 1988 and February 1997. They were composed of 74 cases of ischemic heart disease, 22 cases of valvular disease, 1 case of myxoma, and 24 cases of thoracic aortic disease. Operative mortality r... | 9,251,501 | D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic; D001018:Aortic Diseases; D005260:Female; D006349:Heart Valve Diseases; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia; D012189:Retrospective Studies; D016896:Treatment Outcome | Kyobu geka. The Japanese journal of thoracic surgery | 1,997 | ||
Metformin is associated with decreased skin cancer risk in Taiwanese patients with type 2 diabetes. | BACKGROUND
Metformin, an antidiabetic drug, is associated with decreased cancer risk, but its effect on skin cancer is unknown.
OBJECTIVE
To evaluate skin cancer risk associated with metformin use.
METHODS
In total, 16,237 matched pairs of ever and never metformin users with new-onset type 2 diabetes diagnosed duri... | 10.1016/j.jaad.2017.12.016 | 29,246,826 | D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents; D008297:Male; D008687:Metformin; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012878:Skin Neoplasms; D013624:Taiwan | Journal of the American Academy of Dermatology | 2,018 | D007004:Hypoglycemic Agents; D008687:Metformin |
Age-related differences in neural spectral power during motor learning. | We investigated how older adults preserve the capability to acquire new motor skills in the face of age-related brain alterations. We assessed neural changes associated with learning a bimanual coordination task over 4 days of practice in healthy young (n = 24) and older adults (n = 24). The electroencephalogram was re... | 10.1016/j.neurobiolaging.2018.12.013 | 30,776,651 | D000328:Adult; D000368:Aged; D000375:Aging; D001921:Brain; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D008875:Middle Aged; D009048:Motor Skills; D011597:Psychomotor Performance; D066191:Sensorimotor Cortex; D013647:Task Performance and Analysis; D055815:Young Adult | Neurobiology of aging | 2,019 | |
Using the Multi-Theory Model (MTM) of Health Behavior Change to Explain Yoga Practice. | BACKGROUND
Diverse groups, including college students, are being encouraged to practice yoga. Research suggests that college students fail to attain the mental and physical benefits of yoga practice.
OBJETIVE
The purpose of this study was to utilize the fourth-generation, multi-theory model (MTM) of health behavior c... | 32,827,406 | D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D015438:Health Behavior; D006801:Humans; D019122:Meditation; D013334:Students; D014481:United States; D015013:Yoga | Alternative therapies in health and medicine | 2,022 | ||
Editorial: Psychotherapy for Adolescents With Major Depressive Disorder: More Is Not Necessarily Better. | Depressive disorders are a problem for troubled teenagers, their families, and society at large that is hard to overestimate. In the US, as in many other countries, more than 1 in 3 teenagers report depressive symptoms above clinical cut-off levels, whereas 1 in 5 report having had at least 1 life-time episode of major... | 10.1016/j.jaac.2023.06.018 | 37,414,273 | Journal of the American Academy of Child and Adolescent Psychiatry | 2,023 | ||
Shear bond strength of a denture base acrylic resin and gingiva-colored indirect composite material to zirconia ceramics. | PURPOSE
To evaluate the shear bond strengths of two gingiva-colored materials (an indirect composite material and a denture base acrylic resin) to zirconia ceramics and determine the effects of surface treatment with various priming agents.
METHODS
A gingiva-colored indirect composite material (CER) or denture base a... | 10.1016/j.jpor.2016.07.007 | 27,543,041 | D000180:Acrylic Resins; D002516:Ceramics; D003116:Color; D003188:Composite Resins; D001840:Dental Bonding; D003764:Dental Materials; D003819:Denture Bases; D005881:Gingiva; D011140:Polyurethanes; D033081:Shear Strength; D015040:Zirconium | Journal of prosthodontic research | 2,017 | D000180:Acrylic Resins; C029012:Composite Dental Resin; D003188:Composite Resins; D003764:Dental Materials; D011140:Polyurethanes; D015040:Zirconium; C028541:zirconium oxide |
Stable plasma-deposited acrylic acid surfaces for cell culture applications. | Continuous and modulated glow discharges were used to deposit thin films from acrylic acid vapors. Different deposition regimes were investigated, and their effect on chemical composition, morphology and homogeneity of the coatings, as well as on their stability in water and resistance to sterilization. Stable films we... | 10.1016/j.biomaterials.2004.10.011 | 15,626,431 | D000179:Acrylates; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D002460:Cell Line; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible; D005347:Fibroblasts; D005740:Gases; D006358:Hot Temperature; D006801:Humans; D008422:Materials Testing; D013499:Surface Properties; D023822:Tissue Engineerin... | Biomaterials | 2,005 | D000179:Acrylates; D020099:Coated Materials, Biocompatible; D005740:Gases; C036658:acrylic acid |
[In Nigeria: sexual permissiveness and sex education]. | Considering the population explosion in Nigeria which is due both to medical advances and traditional beliefs in large families as well as the recent trend of sexual permissiveness which involves the teenagers population, the author of the article considers that sex education is imperative in Nigeria. However, he sees ... | 6,618,499 | D001290:Attitude; D005191:Family Characteristics; D005193:Family Planning Services; D006801:Humans; D009549:Nigeria; D012736:Sex Education; D012725:Sexual Behavior | Hygie | 1,983 | ||
Duodenal-Jejunal Bypass Liner (DJBL) Improves Cardiovascular Risk Biomarkers and Predicted 4-Year Risk of Major CV Events in Patients with Type 2 Diabetes and Metabolic Syndrome. | BACKGROUND
The duodenal-jejunal bypass liner (DJBL) represents a novel endoscopic minimally invasive treatment option for obesity-associated type 2 diabetes (T2D), affecting body weight and metabolic control. Until now, the effects of DJBL on cardiovascular risk have never been investigated.
METHODS
Between 2012 and ... | 10.1007/s11695-019-04324-2 | 31,898,040 | D050110:Bariatric Surgery; D015415:Biomarkers; D002318:Cardiovascular Diseases; D003924:Diabetes Mellitus, Type 2; D004386:Duodenum; D000082742:Heart Disease Risk Factors; D006801:Humans; D007583:Jejunum; D024821:Metabolic Syndrome; D009767:Obesity, Morbid; D012307:Risk Factors; D016896:Treatment Outcome | Obesity surgery | 2,020 | D015415:Biomarkers |
Curvature dynamics and long-range effects on fluid-fluid interfaces with colloids. | We investigate the dynamics of a phase-separating binary fluid, containing colloidal dumbbells anchored to the fluid-fluid interface. Extensive lattice Boltzmann-immersed boundary method simulations reveal that the presence of soft dumbbells can significantly affect the curvature dynamics of the interface between phase... | 10.1039/c8sm02396d | 30,816,901 | Soft matter | 2,019 | ||
Tissue response to a supplement high in aluminum and silicon. | The objective was to determine the effects of sodium zeolite A (SZA) on mineral metabolism and tissue mineral composition in calves. Twenty calves were placed on study at 3 days of age and were placed into one of two groups: SS, which received 0.05% BW SZA added to their milk replacer, and CO, which received only milk ... | 10.1007/s12011-007-8039-x | 17,955,202 | D000818:Animals; D002417:Cattle; D019587:Dietary Supplements; D008670:Metals; D009928:Organ Specificity; D012825:Silicon; D017641:Zeolites | Biological trace element research | 2,008 | D008670:Metals; D017641:Zeolites; D012825:Silicon |
Limited dengue virus replication in field-collected Aedes aegypti mosquitoes infected with Wolbachia. | INTRODUCTION
Dengue is one of the most widespread mosquito-borne diseases in the world. The causative agent, dengue virus (DENV), is primarily transmitted by the mosquito Aedes aegypti, a species that has proved difficult to control using conventional methods. The discovery that A. aegypti transinfected with the wMel s... | 10.1371/journal.pntd.0002688 | 24,587,459 | D000330:Aedes; D000818:Animals; D003716:Dengue Virus; D005260:Female; D007303:Insect Vectors; D010572:Pest Control, Biological; D012367:RNA, Viral; D014779:Virus Replication; D020577:Wolbachia | PLoS neglected tropical diseases | 2,014 | D012367:RNA, Viral |
Effect of insulin on spontaneous and progesterone-induced GVBD on Bufo arenarum denuded oocytes. | Progesterone is considered as the physiological steroid hormone that triggers meiosis reinitiation in amphibian oocytes. Nevertheless, isolated oocytes can be induced to undergo germinal vesicle breakdown (GVBD) in a saline medium by means of treatment with various hormones or inducing agents such as other steroid horm... | 10.1017/s0967199404002709 | 15,521,708 | D000276:Adjuvants, Immunologic; D000818:Animals; D003994:Bucladesine; D002022:Bufo arenarum; D006151:Guanosine; D007004:Hypoglycemic Agents; D007328:Insulin; D018021:Lithium Chloride; D009355:Neomycin; D009865:Oocytes; D010716:Phosphatidylinositols; D010726:Phosphodiesterase Inhibitors; D011374:Progesterone; D011500:Pr... | Zygote (Cambridge, England) | 2,004 | D000276:Adjuvants, Immunologic; D007004:Hypoglycemic Agents; D007328:Insulin; D010716:Phosphatidylinositols; D010726:Phosphodiesterase Inhibitors; D011500:Protein Synthesis Inhibitors; D011687:Purines; D006151:Guanosine; D011374:Progesterone; D003994:Bucladesine; D020687:cdc25 Phosphatases; D018021:Lithium Chloride; D0... |
Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes. | Depolarization-induced calcium influx into rat cerebral cortex synaptosomes increased the phosphorylation of several synaptosomal proteins as examined by 32Pi incorporation. A phosphopeptide mapping technique involving NaDodSO4/polyacrylamide gels has been used to show that phosphorylation of a Mr 87,000 substrate prot... | 10.1073/pnas.79.17.5249 | 6,957,862 | D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium; D002147:Calmodulin; D002540:Cerebral Cortex; D003600:Cytosol; D008928:Mitochondria; D008970:Molecular Weight; D009419:Nerve Tissue Proteins; D010718:Phosphatidylserines; D010748:Phosphopeptides; D010766:Phosphorylation; D051381:Rats; D013574:Synapt... | Proceedings of the National Academy of Sciences of the United States of America | 1,982 | D002147:Calmodulin; D009419:Nerve Tissue Proteins; D010718:Phosphatidylserines; D010748:Phosphopeptides; D014701:Veratridine; D002118:Calcium |
Dissipative structures in supersonic turbulence. | We show that density-weighted moments of the dissipation rate, epsilonl, averaged over a scale l, in supersonic turbulence can be successfully explained by the She and Lévêque model [Phys. Rev. Lett. 72, 336 (1994)]. A general method is developed to measure the two parameters of the model, gamma and d, based directly o... | 10.1103/PhysRevLett.102.034501 | 19,257,357 | Physical review letters | 2,009 | ||
Measuring Spatial Accessibility of Health Care Providers - Introduction of a Variable Distance Decay Function within the Floating Catchment Area (FCA) Method. | We integrated recent improvements within the floating catchment area (FCA) method family into an integrated 'iFCA`method. Within this method we focused on the distance decay function and its parameter. So far only distance decay functions with constant parameters have been applied. Therefore, we developed a variable di... | 10.1371/journal.pone.0159148 | 27,391,649 | D005858:Germany; D006282:Health Personnel; D006280:Health Workforce; D006801:Humans; D016015:Logistic Models; D008962:Models, Theoretical; D016011:Normal Distribution; D011320:Primary Health Care | PloS one | 2,016 | |
Distribution of Health Effects and Cost-effectiveness of Varicella Vaccination are Shaped by the Impact on Herpes Zoster. | INTRODUCTION
Varicella zoster virus (VZV) is the etiological agent of varicella and herpes zoster (HZ). It has been hypothesised that immune boosting of latently infected persons by contact with varicella reduces the probability of HZ. If true, universal varicella vaccination may increase HZ incidence due to reduced VZ... | 10.1016/j.ebiom.2015.08.017 | 26,629,544 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002644:Chickenpox; D019433:Chickenpox Vaccine; D002648:Child; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D006562:Herpes Zoster; D014645:Herpesvirus 3, Human; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newb... | EBioMedicine | 2,015 | D019433:Chickenpox Vaccine |
Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. | Signal Transducer and Activator of Transcription-3 (STAT3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. We have shown that STAT3 is constitutively activated in human gastric cancer, and that chronic IL-11-driven STAT3 transcriptional activity i... | 10.1371/journal.pone.0095993 | 24,804,649 | D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D017370:Interleukin-11; D015850:Interleukin-6; D053614:Janus Kinase 2; D051379:Mice; D010766:Phosphorylation; D011725:Pyridines; D050796:STAT3 Transcription Factor; D013274:Stomach Neoplasms; D020032:Tyrphostins | PloS one | 2,014 | D017370:Interleukin-11; D015850:Interleukin-6; D011725:Pyridines; D050796:STAT3 Transcription Factor; D020032:Tyrphostins; C519885:WP1066; C507924:JAK2 protein, human; D053614:Janus Kinase 2 |
Social Prescribing in National Health Service Primary Care: What Are the Ethical Considerations? | Policy Points Social prescribing is proposed as a way of improving patients' health and well-being by attending to their non-clinical needs. This is done by connecting patients with community assets (typically voluntary or charitable organizations) that provide social and personal support. In the United Kingdom, social... | 10.1111/1468-0009.12516 | 34,170,055 | D006801:Humans; D011320:Primary Health Care; D012944:Social Support; D012946:Social Welfare; D013222:State Medicine; D006113:United Kingdom | The Milbank quarterly | 2,021 | |
3,5-Diphenyl-1H-pyrazole derivatives. VI--Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities. | The syntheses of 1-(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole 1 by reaction of 2-hydrazino-1-phenylethanol with dibenzoylmethane, of esters 2 and 2-dialkylaminoethyl ethers 3 starting from 1 as sodium salt and acyl chlorides or 2-chloroethyldialkylamines, respectively, as well as of N,N-disubstituted 1-(2-amino... | 2,222,723 | D000779:Anesthetics, Local; D000818:Animals; D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D002492:Central Nervous System Depressants; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009043:Mot... | Farmaco (Societa chimica italiana : 1989) | 1,990 | D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D002492:Central Nervous System Depressants; D010975:Platelet Aggregation Inhibitors; D011720:Pyrazoles; C066207:1-(2-hydroxy-2-phenylethyl)-3,5-diphenylpyrazole | |
Evaluation of impedance cardiography as a non-invasive means of measuring systolic time intervals and cardiac output. | Impedance cardiography was used for non-invasive determinations of systolic time intervals (STI) and cardiac output. The results were compared with simultaneously obtained invasive measurements of STI from central aortic pressure curves and of cardiac output using the dye-dilution technique. The study was performed on ... | 10.1111/j.1399-6576.1975.tb05243.x | 1,101,602 | D000818:Animals; D001011:Aorta; D001794:Blood Pressure; D002245:Carbon Dioxide; D002302:Cardiac Output; D003864:Depression, Chemical; D004285:Dogs; D004395:Dye Dilution Technique; D006221:Halothane; D006339:Heart Rate; D010100:Oxygen; D010313:Partial Pressure; D010992:Plethysmography, Impedance; D013268:Stimulation, Ch... | Acta anaesthesiologica Scandinavica | 1,975 | D002245:Carbon Dioxide; D010100:Oxygen; D006221:Halothane |
Intrapocket anesthesia for scaling and root planing in pain-sensitive patients. | BACKGROUND
In 2 previous multicenter studies evaluating the efficacy of a novel anesthetic gel (lidocaine 25 mg/g plus prilocaine 25 mg/g), there was a rather small, although statistically significant, overall difference between the active and placebo gels. There were, however, large center variations. At centers where... | 10.1902/jop.2003.74.5.597 | 12,828,139 | D000328:Adult; D000368:Aged; D000766:Anesthesia, Dental; D000779:Anesthetics, Local; D012534:Dental Scaling; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D010146:Pain; D010147:Pain Measurement; D010514:Periodo... | Journal of periodontology | 2,003 | D000779:Anesthetics, Local; D005782:Gels; D010919:Placebos; D011318:Prilocaine; D008012:Lidocaine |
An injury paradigm to investigate central nervous system repair in Drosophila. | An experimental method has been developed to investigate the cellular responses to central nervous system (CNS) injury using the fruit-fly Drosophila. Understanding repair and regeneration in animals is a key question in biology. The damaged human CNS does not regenerate, and understanding how to promote the regenerati... | 10.3791/50306 | 23,567,253 | D000818:Animals; D002490:Central Nervous System; D004330:Drosophila; D005260:Female; D008297:Male; D018613:Microscopy, Confocal; D009457:Neuroglia; D009474:Neurons; D012038:Regeneration; D013119:Spinal Cord Injuries | Journal of visualized experiments : JoVE | 2,013 | |
Outcomes and evaluation of flexor tendon repair. | This article reviews recent reports of outcomes of flexor tendon repair and discusses the problems associated with such surgeries. Reports of no repair rupture in individual case series have emerged recently. Their results move toward the clinical goal of primary repair without repair rupture. The Strickland method rem... | 23,660,061 | D005383:Finger Injuries; D006801:Humans; D010043:Outcome and Process Assessment, Health Care; D016059:Range of Motion, Articular; D012421:Rupture; D013708:Tendon Injuries; D014945:Wound Healing | Hand clinics | 2,013 | ||
Appointment zen - shaping demand and matching capacity. | BACKGROUND
Ten years of experience with hundreds of general practices in the Australian Primary Care Collaboratives program has provided many lessons for improving practice appointment systems.
OBJECTIVE
In this article, we describe how general practitioners can, by actively managing our appointment systems, reduce w... | 24,701,629 | D001071:Appointments and Schedules; D001315:Australia; D003266:Continuity of Patient Care; D034742:Electronic Mail; D058006:General Practice; D006297:Health Services Accessibility; D006801:Humans; D005791:Patient Care; D017060:Patient Satisfaction; D011216:Practice Management, Medical; D011320:Primary Health Care; D011... | Australian family physician | 2,014 | ||
Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation. | Mammalian target of rapamycin (mTOR) plays a range of crucial roles in cell survival, growth, proliferation, metabolism, and morphology. However, mTOR forms two distinct complexes, mTOR complex 1 and mTOR complex 2 (mTORC1 and mTORC2), via association with a series of different components; this allows the complexes to ... | 10.1038/srep41159 | 28,106,162 | D000818:Animals; D001665:Binding Sites; D002454:Cell Differentiation; D002460:Cell Line; D055786:Gene Knockout Techniques; D057809:HEK293 Cells; D034761:Heterogeneous-Nuclear Ribonucleoprotein Group M; D006801:Humans; D017874:Immediate-Early Proteins; D051379:Mice; D032446:Myoblasts; D010766:Phosphorylation; D011485:Pr... | Scientific reports | 2,017 | D034761:Heterogeneous-Nuclear Ribonucleoprotein Group M; D017874:Immediate-Early Proteins; D000076226:Rapamycin-Insensitive Companion of mTOR Protein; C525637:rictor protein, mouse; D017346:Protein Serine-Threonine Kinases; C080320:serum-glucocorticoid regulated kinase; C496630:Prkca protein, mouse; D051571:Protein Kin... |
Giant cell tumor of the tendon sheath: a rare periungual location simulating myxoid cyst. | Giant cell tumor of the tendon sheath is a benign soft tissue tumor most frequent between the third and fifth decades of life. It can mimic and make differential diagnoses with several hand tumors. Definitive diagnosis and the treatment of choice are reached with complete resection and histopathological examination. He... | 10.1590/abd1806-4841.20175229 | 28,225,971 | D003937:Diagnosis, Differential; D005260:Female; D045888:Ganglion Cysts; D000070779:Giant Cell Tumor of Tendon Sheath; D006801:Humans; D008875:Middle Aged; D009260:Nail Diseases; D012878:Skin Neoplasms | Anais brasileiros de dermatologia | 2,017 | |
Insight into the pattern of heavy-metal accumulation in lichen thalli. | BACKGROUND
Heavy metals that pass through the plasmalemma are expected to influence on lichen metabolic processes; however, lichens may tolerate high concentrations of metals by sequestrating them extracellularly. Heavy metal accumulation level fundamentally determine the success of lichens in the colonisation of pollu... | 10.1016/j.jtemb.2020.126512 | 32,299,012 | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) | 2,020 | ||
Group interpersonal psychotherapy for veterans with posttraumatic stress disorder: a pilot study. | Group-based interpersonal psychotherapy (IPT-G) was provided to nine male Vietnam veterans with posttraumatic stress disorder (PTSD) to reduce interpersonal difficulties. Standardized measures of posttraumatic stress, depression, interpersonal problems, and functioning were administered pre- and posttreatment and at 2-... | 10.1521/ijgp.2010.60.1.131 | 20,059,298 | D000368:Aged; D003130:Combat Disorders; D015897:Comorbidity; D003866:Depressive Disorder; D005500:Follow-Up Studies; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D009517:New South Wales; D010555:Personality Inventory; D011575:Psychoanalytic Therapy; D011615:Psychotherapy, Group; D... | International journal of group psychotherapy | 2,010 | |
Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus. | BACKGROUND
The impact of a given presynaptic neuron on the firing probability of the postsynaptic neuron critically depends on the number of functional release sites that connect the two neurons. One way of determining the average functional synaptic connectivity onto a postsynaptic neuron is to compare the amplitudes ... | 10.1186/1471-2202-13-14 | 22,276,909 | D015763:2-Amino-5-phosphonovalerate; D000367:Age Factors; D000779:Anesthetics, Local; D000818:Animals; D000831:Animals, Newborn; D001703:Biophysics; D056547:CA1 Region, Hippocampal; D003342:Corpus Striatum; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists; D005260:Female; D066298:In Vitro Techniq... | BMC neuroscience | 2,012 | D000779:Anesthetics, Local; D018691:Excitatory Amino Acid Antagonists; D026941:Sodium Channel Blockers; C012647:QX-314; D013779:Tetrodotoxin; D015763:2-Amino-5-phosphonovalerate; D008012:Lidocaine |
Shigella Spa33 is an essential C-ring component of type III secretion machinery. | Type III secretion machinery (TTSM), composed of a needle, a basal body, and a C-ring compartment, delivers a subset of effectors into host cells. Here, we show that Shigella Spa33 is an essential component of the C-ring compartment involved in mediating the transit of various TTSM-associated translocated proteins. Ele... | 10.1074/jbc.M509644200 | 16,246,841 | D000251:Adenosine Triphosphatases; D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D003593:Cytoplasm; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D012763:Shigella flexneri | The Journal of biological chemistry | 2,006 | D001426:Bacterial Proteins; D000251:Adenosine Triphosphatases; C478167:Spa47 protein, Shigella flexneri |
Between-Tactor Display Using Dynamic Tactile Stimuli for Directional Cueing in Vibrating Environments. | Torso-worn vibrotactile devices have been used in many studies on directional cueing and navigation in environments where visual feedback is limited. These devices aim to indicate directions with high resolution while using the smallest possible number of vibration motors (tactors). Resolution can be increased using be... | 10.1109/TOH.2023.3304953 | 37,578,911 | IEEE transactions on haptics | 2,023 | ||
Traumatic dislocation of LASIK flaps 4 and 9 years after surgery. | PURPOSE
To report two patients who developed a corneal flap dehiscence 4 years and 9 years after LASIK, respectively, following trauma during routine domestic activities.
METHODS
Retrospective chart review of two patients. Clinical presentation, mechanism of injury, treatment, complications, and outcome were studied.... | 10.3928/1081597X-20090710-03 | 20,677,731 | D000062:Accidents, Occupational; D000328:Adult; D000818:Animals; D003319:Corneal Stroma; D004285:Dogs; D005131:Eye Injuries; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008297:Male; D012189:Retrospective Studies; D013524:Surgical Flaps; D013529:Surgical Wound Dehiscence; D013997:Time Factors; D014792:Visual... | Journal of refractive surgery (Thorofare, N.J. : 1995) | 2,010 | |
Translocation of aged cyclodiene insecticide residues from soil into forage crops and pastures at various growth stages under field conditions. | Field trials were conducted to measure translocation of pesticides by summer and winter forage/pasture species from soil containing aged residues of heptachlor and, to a lesser extent, dieldrin. Substantial amounts of heptachlor epoxide, and lesser amounts of gamma-chlordane were translocated to plants from contaminate... | 10.1080/03601239209372808 | 1,460,243 | D000821:Animal Feed; D000818:Animals; D000829:Animals, Domestic; D002706:Chlordan; D004026:Dieldrin; D002523:Edible Grain; D007887:Fabaceae; D005506:Food Contamination; D006533:Heptachlor; D006534:Heptachlor Epoxide; D007306:Insecticides; D010573:Pesticide Residues; D063245:Plant Development; D010944:Plants; D010946:Pl... | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes | 1,992 | D007306:Insecticides; D010573:Pesticide Residues; D012989:Soil Pollutants; D006534:Heptachlor Epoxide; D002706:Chlordan; D006533:Heptachlor; D004026:Dieldrin |
Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy. | Mitochondria dynamically change their morphology via fusion and fission, a process called mitochondrial dynamics. Dysregulated mitochondrial dynamics respond rapidly to metabolic cues, and are linked to the initiation and progression of diverse human cancers. Metabolic adaptations significantly contribute to tumor deve... | 10.1016/j.biopha.2023.115342 | 37,633,053 | D006801:Humans; D051272:Glucose Transporter Type 1; D063154:Mitochondrial Dynamics; D056564:Sirtuin 1; D008928:Mitochondria; D005947:Glucose; D009369:Neoplasms; D024101:Mitochondrial Proteins; D045726:Metalloproteases | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 2,023 | D051272:Glucose Transporter Type 1; D056564:Sirtuin 1; D005947:Glucose; C447939:SIRT1 protein, human; C485223:PARL protein, human; D024101:Mitochondrial Proteins; D045726:Metalloproteases |
Thin aggregative fimbriae enhance Salmonella enteritidis biofilm formation. | Salmonella enteritidis enteropathogens produce a variety of potentially adherent fimbrial types including SEF14, SEF17, SEF18 and SEF21 (type I). In a simplified, pure culture, biofilm generating system the virulent isolate, S. enteritidis 3b, readily adhered to Teflon (polytetrafluoroethylene) and stainless steel form... | 10.1111/j.1574-6968.1998.tb13012.x | 9,627,964 | D001422:Bacterial Adhesion; D018441:Biofilms; D015153:Blotting, Western; D004591:Electrophoresis, Polyacrylamide Gel; D010861:Fimbriae, Bacterial; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D012477:Salmonella enteritidis | FEMS microbiology letters | 1,998 | |
A dimeric iridoid from loasa acerifolia. | Reinvestigation of leaf material from Loasa acerifolia DOMBEY led to the isolation of secoxyloganin and an additional novel dimeric iridoid glucoside named asaolaside. The latter consists of a secoxyloganin moiety esterified to the 7-hydroxy group of sylvestroside IV. The structure of asaolaside was established by 1D a... | 10.1016/s0031-9422(98)00194-0 | 11,711,085 | Phytochemistry | 1,998 | ||
The effect of chiropractic treatment on infantile colic: study protocol for a single-blind randomized controlled trial. | Background
Infantile colic is a common condition during early childhood affecting around one of six newborns. The condition is characterized by inconsolable crying and fussing in otherwise healthy and thriving infants. The most used definition is excessive crying for at least three hours a day for at least three days f... | 10.1186/s12998-018-0188-9 | 29,930,798 | D003085:Colic; D003448:Crying; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D026882:Manipulation, Chiropractic; D010865:Pilot Projects; D016037:Single-Blind Method; D016896:Treatment Outcome | Chiropractic & manual therapies | 2,018 | |
The damage response framework and infection prevention: From concept to bedside. | Hospital-acquired infections remain a common cause of morbidity and mortality despite advances in infection prevention through use of bundles, environmental cleaning, antimicrobial stewardship, and other best practices. Current prevention strategies and further hospital-acquired infection reduction are limited by lack ... | 10.1017/ice.2019.354 | 31,915,082 | D003428:Cross Infection; D020000:Decision Support Systems, Clinical; D005260:Female; D006801:Humans; D017053:Infection Control; D000069550:Machine Learning; D008297:Male; D064307:Microbiota; D008954:Models, Biological; D018570:Risk Assessment | Infection control and hospital epidemiology | 2,020 | |
[SEM observation of the interface between hydroxyapatite ceramic and metal compound implant materials]. | This article described the results of interface between HAP ceramic and metal compound system when the bio-glass burning method was used with Scanning Electro-microscope (SEM). According to the results, the author concluded that as a method of forming compound implant system, bio-glass is a good vehicle between HAP and... | 2,517,927 | D003722:Dental Alloys; D015921:Dental Implants; D003776:Dental Porcelain; D006882:Hydroxyapatites; D008855:Microscopy, Electron, Scanning; D013057:Spectrum Analysis | Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology | 1,989 | D003722:Dental Alloys; D015921:Dental Implants; D006882:Hydroxyapatites; D003776:Dental Porcelain | |
Effects of Dietary Inositol Supplementation on Growth, Digestive Performance, Antioxidant Capacity, and Body Composition of Golden Pompano (Trachinotus ovatus). | A 56-day culture experiment was performed to evaluate effects of inositol supplementation on growth, digestive performance, antioxidant capacity, and body composition of golden pompano (Trachinotus ovatus). Five experimental diets (D1, D2, D3, D4, and D5) supplemented with 0, 150, 300, 600, and 1,200 mg kg-1 inositol w... | 10.3389/fphys.2022.850470 | 35,222,100 | Frontiers in physiology | 2,022 | ||
Optimizing Glaucoma Care: A Holistic Approach. | How to cite this article: Dada T, Chauhan N. Optimizing Glaucoma Care: A Holistic Approach. J Curr Glaucoma Pract 2023;17(3):111-112. | 10.5005/jp-journals-10078-1416 | 37,920,376 | Journal of current glaucoma practice | 2,023 | ||
Behaviour problems in childhood and stressors in early adult life. I. A 20 year follow-up of London school children. | The research presented in this paper examined the relationship between the presence of childhood behaviour problems and the rate of life events and difficulties in early adult life. Data are presented from a 20 year follow-up study of a sample of inner London school children first studied when they were aged 10. The ke... | 10.1017/s003329170003614x | 7,675,912 | D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms; D002648:Child; D002653:Child Behavior Disorders; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008016:Life Change Events; D008131:London; D008297:Male; D001523:Mental Disorders; D010287:Parent-Child Relations; D010552:P... | Psychological medicine | 1,995 | |
Prenatal developmental toxicity evaluation of 2',3'-dideoxyinosine (ddI) and 2',3'-didehydro-3'-deoxythymidine (d4T) co-administered to Swiss Albino (CD-1) mice. | BACKGROUND
In pregnant women, antiretroviral drugs improve maternal health and reduce vertical transmission of human immunodeficiency virus to the infant. However, few nonclinical studies have examined the potential for adverse drug interactions.
METHODS
On gestational days (GD) 6-16, mice were dosed with vehicle, dd... | 10.1002/bdrb.20076 | 16,767,756 | D000818:Animals; D021461:Animals, Outbred Strains; D016049:Didanosine; D010064:Embryo Implantation; D005247:Feeding Behavior; D005260:Female; D005313:Fetal Death; D020567:Fetal Weight; D005333:Fetus; D008098:Litter Size; D051379:Mice; D009929:Organ Size; D011247:Pregnancy; D018119:Stavudine | Birth defects research. Part B, Developmental and reproductive toxicology | 2,006 | D018119:Stavudine; D016049:Didanosine |
Development and Feasibility of a Home Pulmonary Rehabilitation Program With Health Coaching. | BACKGROUND
Pulmonary rehabilitation (PR) is an effective intervention for COPD. However, traditional center-based PR programs suffer from low uptake. Home-based PR is a viable solution, but few studies have shown the effectiveness of remote PR, as there is a scarcity of systems that can be easily adopted in clinical pr... | 10.4187/respcare.05690 | 29,066,590 | D000368:Aged; D005081:Exercise Therapy; D005240:Feasibility Studies; D005260:Female; D006699:Home Care Services; D006801:Humans; D008297:Male; D000071252:Mentoring; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010349:Patient Compliance; D017060:Patient Satisfaction; D010865:Pilot Projects; D015397:Program Eva... | Respiratory care | 2,018 | |
The immediate haemodynamic response to the initiation of extracorporeal membrane oxygenation in a piglet model of infant hypoxic respiratory failure. | There is evidence that haemodynamic fluctuations on extracorporeal membrane oxygenation (ECMO) increase the risk of cerebral damage. We hypothesized that initiation of venovenous (VV) or venoarterial (VA) ECMO itself causes haemodynamic fluctuations and, thus, established an infant animal ECMO model in order to discuss... | 10.1191/0267659102pf609oa | 12,470,031 | D000818:Animals; D000831:Animals, Newborn; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006439:Hemodynamics; D000860:Hypoxia; D012131:Respiratory Insufficiency; D013552:Swine | Perfusion | 2,002 | |
Bioactive hybrid membrane-based cellulose acetate/bioactive glass/hydroxyapatite/carbon nanotubes nanocomposite for dental applications. | The present work aimed to fabricate a set of hybrid bioactive membrane in the form of bio-nanocomposite films for dental applications using the casting dissolution procedures. The formulation of the targeted materials was consisting of cellulose acetate/bioactive glass/hydroxyapatite/carbon nanotubes with a general abb... | 10.1016/j.jmbbm.2023.105795 | 37,001,249 | D000818:Animals; D002522:Chlorocebus aethiops; D017886:Durapatite; D037742:Nanotubes, Carbon; D014709:Vero Cells; D053761:Nanocomposites | Journal of the mechanical behavior of biomedical materials | 2,023 | D017886:Durapatite; D037742:Nanotubes, Carbon; C005062:acetylcellulose |
Multiple Skin Neoplasms at One Site (MUSK IN A NEST): A Comprehensive Review of Basal Cell Carcinoma and Benign or Malignant "Collision" Tumors at the Same Cutaneous Location. | Multiple skin neoplasms at one site (MUSK IN A NEST), initially referred to as a collision tumor, describes the occurrence of two or more benign or malignant neoplasms that are adjacent or intermingled at the same cutaneous site. A mononeoplastic cutaneous tumor refers to a single tumor at any cutaneous site. Two, thre... | 10.2147/CCID.S259324 | 33,061,513 | Clinical, cosmetic and investigational dermatology | 2,020 | ||
Classification and diagnosis of mastocytosis: current status. | Mastocytosis is a disease characterized by an abnormal increase in mast cells. Manifestations of the disease are provoked in large part by the resultant increase in mast cell-derived mediators, which have a variety of local and systemic effects. Mastocytosis is variable in respect to the organ systems involved, clinica... | 10.1111/1523-1747.ep12468882 | 16,799,601 | D006801:Humans; D008415:Mastocytosis | The Journal of investigative dermatology | 1,991 | |
Characterization of Bothrops jararaca coagulation inhibitor (BjI) and presence of similar protein in plasma of other animals. | BjI, a protein isolated from Bothrops jararaca snake blood, inhibits the coagulant activity of thrombin. This protein presents two bands of 109 and 138 kDa by SDS-PAGE under reducing conditions. In order to verify the presence of BjI-like proteins in plasma of other animals (reptiles and non-reptiles), we raised a spec... | 10.1016/j.toxicon.2004.06.001 | 15,302,535 | D000595:Amino Acid Sequence; D000818:Animals; D001777:Blood Coagulation; D001798:Blood Proteins; D015153:Blotting, Western; D017837:Bothrops; D001938:Brazil; D003429:Cross Reactions; D003435:Crotalid Venoms; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D007106:Immune Sera; D05... | Toxicon : official journal of the International Society on Toxinology | 2,004 | C043517:2-(4-isothiocyanatophenoxy)-1,3,2-dioxaphosphinene 2-oxide; D001798:Blood Proteins; C477871:Bothrops jararaca inhibitor; D003435:Crotalid Venoms; D007106:Immune Sera; D009943:Organophosphorus Compounds |
Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction. | BACKGROUND
Ganoderma lucidum has been widely used as a herbal medicine for promoting health and longevity in China and other Asian countries. Polysaccharide extracts from Ganoderma lucidum have been reported to exhibit immuno-modulating and anti-tumor activities. In previous studies, F3, the active component of the pol... | 10.1186/1471-2164-8-411 | 17,996,095 | D017209:Apoptosis; D015153:Blotting, Western; D045744:Cell Line, Tumor; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D004797:Enzyme-Linked Immunosorbent Assay; D020869:Gene Expression Profiling; D006801:Humans; D007948:Leukemia, Monocytic, Acute; D020411:Oligonucleotide Array Sequence Analysis; D010936:Plant Extra... | BMC genomics | 2,007 | D016207:Cytokines; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D011134:Polysaccharides; D053218:Receptors, Death Domain |
Genetic polymorphism of six transmembrane protein of prostate 2 associated with diabetes mellitus in Xinjiang Uygur population. | OBJECTIVE
To investigate the association between the genetic variations of six transmembrane protein of prostate 2 (STAMP2) with type 2 diabetes mellitus (T2DM) in Xinjiang Uygur population.
METHODS
A case-control study was conducted based on epidemiological investigation. A total of 1838 Uygur subjects were selected... | 10.3881/j.issn.1000-503X.2012.05.013 | 23,134,829 | D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D003920:Diabetes Mellitus; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D010088:Oxidoreductases; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae | 2,012 | D008565:Membrane Proteins; D010088:Oxidoreductases; C503310:STEAP4 protein, human |
Can learning to sustain life be BASIC? Teaching for the initial management of the critically ill in Australia and New Zealand. | Commonly in Australia and New Zealand, initial intensive care support of critically ill patients is by non-intensive care trained medical and nursing staff Basic Assessment and Support in Intensive Care (BASIC) is an internationally run short course to assist practitioners to gain knowledge and skills to manage the ear... | 10.1177/0310057X1003800614 | 21,226,436 | D001315:Australia; D003422:Critical Care; D016638:Critical Illness; D004502:Education, Medical, Continuing; D006801:Humans; D008020:Life Support Care; D009520:New Zealand | Anaesthesia and intensive care | 2,010 | |
[Receptivity of some Helicids frequent in Morocco to the infestation by the larvae of Protostongylids. Factors of variation (author's transl)]. | Several species of Helicids common on pasture in the Rabat area were infected by a plurispecific mixture of larvae of Protostrongylids. The fecal or pulmonary origin of the larvae does not seem to influence their infective ability. The age of the larvae used for infection displays an important role on the future degree... | 533,113 | D000367:Age Factors; D000818:Animals; D006372:Helix, Snails; D006790:Host-Parasite Interactions; D007814:Larva; D009018:Morocco; D009348:Nematoda; D013045:Species Specificity | Annales de parasitologie humaine et comparee | 1,979 | ||
Hyperhomocysteinemia and risk for peripheral arterial occlusive disease in young women. | OBJECTIVE
Few studies to date have examined the relationship between hyperhomocysteinemia and peripheral arterial occlusive disease (PAOD) in young women. In this study we assessed hyperhomocysteinemia as a risk factor for PAOD in young women. In addition, we evaluated the effect of joint exposure to hyperhomocysteinem... | 10.1016/s0741-5214(03)00476-2 | 14,560,229 | D000293:Adolescent; D000328:Adult; D001157:Arterial Occlusive Diseases; D001161:Arteriosclerosis; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia; D008875:Middle Aged; D016017:Odds Ratio; D016491:Peripheral Vascular Diseases; D012307:Risk Factors | Journal of vascular surgery | 2,003 | |
Development of an online incident-reporting system for management of medical risks at hospital. | To minimize their occurrence, it is important to gather and analyze data regarding cases of not only medical accidents but also of incidents involving potential harm to patients. In gathering data, we have separated reporting between the details of such incidents and information about their occurrence. We have implemen... | 10.1248/yakushi.131.1353 | 21,881,311 | D006761:Hospitals; D006801:Humans; D020407:Internet; D019300:Medical Errors; D061214:Patient Safety; D012308:Risk Management; D013997:Time Factors | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan | 2,011 | |
Elevated plasma interleukin-37 levels in systemic lupus erythematosus patients. | This study aims to evaluate the plasma interleukin (IL)-37 levels in systemic lupus erythematosus (SLE) patients, as well as its association with major clinical and laboratory features. Ninety consecutively selected SLE patients and 78 community-based healthy controls were recruited. Plasma IL-37 levels were detected b... | 10.1177/0961203316646462 | 27,125,292 | D000328:Adult; D000974:Antibodies, Antinuclear; D015415:Biomarkers; D003176:Complement C3; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1; D008180:Lupus Erythematosus, Systemic; D008297:Male; D008875:Middle Aged; D015854:Up-Regulation | Lupus | 2,016 | D000974:Antibodies, Antinuclear; D015415:Biomarkers; D003176:Complement C3; C508587:IL37 protein, human; D007375:Interleukin-1 |
Theta-rhythmically firing neurons in the anterior thalamus: implications for mnemonic functions of Papez's circuit. | In 1937 Papez described an anatomical circuit (or loop) beginning and ending in the hippocampal formation that he proposed subserved emotional experience (Papez, 1937). Specifically, the projections of the circuit were as follows: hippocampal formation--> mammillary bodies--> anterior thalamus--> cingulate cortex--> pa... | 10.1016/s0306-4522(01)00131-2 | 11,440,795 | D000200:Action Potentials; D000818:Animals; D020643:Anterior Thalamic Nuclei; D001683:Biological Clocks; D003344:Cortical Synchronization; D006624:Hippocampus; D008297:Male; D008568:Memory; D009434:Neural Pathways; D009474:Neurons; D010507:Periodicity; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-D... | Neuroscience | 2,001 | |
Nucleotide sequence of the 3' end of MCF 247 murine leukemia virus. | We isolated DNA clones of MCF 247, a leukemogenic, recombinant type C virus obtained from the thymus of an AKR mouse. We determined the nucleotide sequence of the viral long terminal repeat (LTR) and the 3' end of env, and we compared the sequences to corresponding sequences of the genome of Akv virus, the putative eco... | 10.1128/JVI.45.1.291-298.1983 | 6,296,437 | D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004279:DNA, Viral; D005814:Genes, Viral; D009052:Leukemia Virus, Murine; D051379:Mice; D008806:Mice, Inbred AKR; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014764:Viral Proteins | Journal of virology | 1,983 | D004279:DNA, Viral; D014764:Viral Proteins |
Effect of fish oil supplement in maintenance hemodialysis patients: a systematic review and meta-analysis of published randomized controlled trials. | PURPOSE
The purpose of this study was to systematically assess the efficacy of fish oil therapy on maintenance hemodialysis patients (MHD).
METHODS
Electronic databases, including PubMed, Cochrane library, EMBase, and Web of Science, were searched for randomized controlled trials (RCTs) of fish oil versus placebo or ... | 10.1007/s00228-015-1976-y | 26,558,899 | D019587:Dietary Supplements; D005395:Fish Oils; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis | European journal of clinical pharmacology | 2,016 | D005395:Fish Oils |
Possible role of histamine in pathogenesis of autoimmune diseases: implications for immunotherapy with histamine-2 receptor antagonists. | The immunosuppressive chemical drugs cyclosporine A (CsA) and methotrexate (Mx) have recently been shown to be of benefit in several different diseases of autoimmune origin. Cellular immune responses may play a major role in autoimmunity as autoreactive T lymphocytes appear to recognize autoantigens and major histocomp... | 10.1016/0306-9877(92)90060-p | 1,362,972 | D001327:Autoimmune Diseases; D015551:Autoimmunity; D016572:Cyclosporine; D006632:Histamine; D006635:Histamine H2 Antagonists; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D008285:Major Histocompatibility Complex; D008727:Methotrexate; D008954:Models, Biological; D011565:Psoriasis; D013601:T-Lympho... | Medical hypotheses | 1,992 | D006635:Histamine H2 Antagonists; D006632:Histamine; D016572:Cyclosporine; D008727:Methotrexate |
Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats: a chronic constriction injury long-term evaluation. | Chronic constriction injury (CCI) simulates the symptoms of chronic nerve compression, which is characterized by allodynia and hyperalgesia. Nerve growth factor (NGF) is released after nerve injury by immune and Schwann cells and transported in retrograde fashion to the dorsal root ganglion (DRG), resulting in increase... | 28,685,530 | D000818:Animals; D002908:Chronic Disease; D005727:Ganglia, Spinal; D006930:Hyperalgesia; D008297:Male; D020932:Nerve Growth Factor; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve; D013116:Spinal Cord; D013373:Substance P | Journal of biological regulators and homeostatic agents | 2,017 | D013373:Substance P; D020932:Nerve Growth Factor |
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