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Safety, effectiveness, and cost effectiveness of metabolic surgery in the treatment of type 2 diabetes mellitus. | Remission of type 2 diabetes mellitus with metabolic surgery is a field of active investigation and development. The extraordinary results obtained in diabetic patients with BMI > 35 kg/m(2) have led investigators to query if similar results could be achieved in patients with BMI < 35 kg/m(2). A few studies have been r... | 10.1155/2011/790683 | 21,113,308 | Journal of obesity | 2,011 | ||
Guided bone regeneration in long-bone defects with a structural hydroxyapatite graft and collagen membrane. | There are few synthetic graft alternatives to treat large long-bone defects resulting from trauma or disease that do not incorporate osteogenic or osteoinductive factors. The aim of this study was to test the additional benefit of including a permeable collagen membrane guide in conjunction with a preformed porous hydr... | 10.1089/ten.TEA.2012.0057 | 22,844,877 | D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration; D003094:Collagen; D017886:Durapatite; D011817:Rabbits; D054457:Tissue Scaffolds; D014945:Wound Healing | Tissue engineering. Part A | 2,013 | D001672:Biocompatible Materials; D003094:Collagen; D017886:Durapatite |
Co9S8 nanotube arrays supported on nickel foam for high-performance supercapacitors. | Uniform Co9S8 nanotube arrays on conductive nickel foam were successfully synthesized through a facile two-step hydrothermal method and were directly applied as the electrode for high-performance electrochemical capacitors. The formation of the tubular structure of Co9S8 can be attributed to the nanoscale Kirkendall ef... | 10.1039/c3cp54192d | 24,276,526 | Physical chemistry chemical physics : PCCP | 2,014 | ||
Infra-cardiac TAPVC with an intrahepatic portosystemic shunt: A rare association. | Total anomalous pulmonary venous connection (TAPVC) is an uncommonly encountered cyanotic congenital heart disease characterized by anomalous drainage of the pulmonary veins. Concomitant venous anomalies are rarely found in these patients. We present a case of an infra-cardiac TAPVC with an intrahepatic portosystemic s... | 10.4103/apc.apc_217_21 | 37,152,507 | Annals of pediatric cardiology | 2,022 | ||
Lymphoid subsets in acute myeloid leukemias: increased number of cells with NK phenotype and normal T-cell distribution. | Natural killer (NK) and T subsets were analyzed with appropriate dual labeling by flow cytometry in peripheral blood (PB) (66 cases) and bone marrow (BM) (55 cases) from patients with de novo AML in order to determine: (a) their distribution at diagnosis, (b) the correlation between PB and BM in NK subpopulations, (c) ... | 10.1007/BF01715050 | 7,694,663 | D000208:Acute Disease; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D016516:CD4-CD8 Ratio; D019002:CD56 Antigen; D006801:Humans; D007694:Killer Cells, Natural; D007951:Leukemia, Myeloid; D007958:Leukocyte Count; D016131:Lymphocyte Subsets; D010641:Phenotype; D017452:Receptors, IgG; D016176:T-L... | Annals of hematology | 1,993 | D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D019002:CD56 Antigen; D017452:Receptors, IgG |
Interleukin-4 and interferon-gamma regulate differentiation of CD8+ T cells into populations with divergent cytokine profiles. | The ability of CD8+ T cells to synthesise and secrete cytokines before and after culture with interleukin (IL)-4 and anti-interferon (IFN)-gamma was investigated. Purified rat splenic CD8+ and CD4+ T cells and CD4-CD8- cells were stimulated with phorbol myristate acetate (PMA) and ionomycin for 6 h and expression of mR... | 10.1159/000236972 | 7,613,127 | D000818:Animals; D018414:CD8-Positive T-Lymphocytes; D002454:Cell Differentiation; D002478:Cells, Cultured; D007371:Interferon-gamma; D015847:Interleukin-4; D007378:Interleukins; D015759:Ionomycin; D008213:Lymphocyte Activation; D008222:Lymphokines; D012333:RNA, Messenger; D051381:Rats; D013154:Spleen; D013755:Tetradec... | International archives of allergy and immunology | 1,995 | D007378:Interleukins; D008222:Lymphokines; D012333:RNA, Messenger; D015847:Interleukin-4; D015759:Ionomycin; D007371:Interferon-gamma; D013755:Tetradecanoylphorbol Acetate |
Ionic liquid-copolymerized monolith based porous layer open tubular column for CEC-MS analysis. | Developing novel capillary electrochromatography (CEC) column with high separation efficiency and capacity is an essential work in CEC. In this work, porous layer open tubular (PLOT) column has been developed by co-polymerization of quaternary ammonium typed ionic liquid (IL), 1-allyl-methylimidazolium chloride (AlMeIm... | 10.1016/j.talanta.2019.120556 | 31,892,017 | Talanta | 2,020 | ||
Canary in the coal mine. | SUMMARY The author explains that lesbians' failure to "succeed" at coupling should be seen as a warning to all of humanity that the institution of marriage is not a viable relationship model. | 10.1300/J155v03n01_23 | 24,786,041 | Journal of lesbian studies | 1,999 | ||
Effects of serum from human subjects of various ages on proliferation of human lung and skin fibroblasts. | We carried out a study to determine whether serum from old human subjects inhibited cell proliferation. The results showed that serum from old subjects of either sex did not greatly inhibit the proliferation of human fetal lung fibroblast TIG-1 cells, even when serum from subjects in their 80s was used. The same result... | 10.1016/0014-4827(88)90399-0 | 3,169,131 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002455:Cell Division; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts; D006801:Humans; D008168:Lung; D008297:Male; D008875:Middle Aged; D012867:Skin | Experimental cell research | 1,988 | |
SYNTHESIS, STRUCTURE AND PHARMACOLOGICAL EVALUATION OF 1-(1H-PYRROL-1-YLMETHYL)-4-AZATRICYCLO[5.2.1.0(2,6)] DEC-8-ENE-3,5-DIONE. | A set of arylpiperazine derivatives with imide fragments, 1-(1H-pyrrol-1-ylmethyl)-10-oxa-4-azatricyclo[5.2.1.0(2,6)-]dec-8-ene-3,5-dione connected by propyl and butyl linkers, were synthesized and tested for the potential anxiolytic and antidepressant activities. Compounds 3a and 3b demonstrated antidepressant activit... | 29,648,718 | D000818:Animals; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D008297:Male; D051379:Mice; D009043:Motor Activity; D010879:Piperazines | Acta poloniae pharmaceutica | 2,016 | D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010879:Piperazines | |
Fas ligand exerts its pro-inflammatory effects via neutrophil recruitment but not activation. | Fas ligand (FasL) expression induces apoptosis of activated T cells and has been suggested as a strategy to inhibit graft rejection. Unfortunately, the use of FasL to confer 'immune privilege' in this setting has been hampered by the finding that it may also provoke a destructive granulocytic response. While the Fas/Fa... | 10.1111/j.1365-2567.2006.02504.x | 17,233,740 | D000818:Animals; D017209:Apoptosis; D002478:Cells, Cultured; D002630:Chemotactic Factors; D002634:Chemotaxis, Leukocyte; D004306:Dose-Response Relationship, Immunologic; D015536:Down-Regulation; D053222:Fas Ligand Protein; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D018375:Neutrophil Activation; D0205... | Immunology | 2,007 | D002630:Chemotactic Factors; D053222:Fas Ligand Protein; D011994:Recombinant Proteins |
Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus. | BACKGROUND
Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas. In addition, it is a potential biowarfare agent.
METHODOLOGY/PRINCIPAL FINDINGS
We developed two potential vaccines, DNA plas... | 10.1371/journal.pntd.0000725 | 20,582,312 | D000524:Alphavirus; D000704:Analysis of Variance; D000818:Animals; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D002460:Cell Line; D015933:Complement C3d; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007132:Immunoglobulin Isotypes; D051379:Mi... | PLoS neglected tropical diseases | 2,010 | D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007132:Immunoglobulin Isotypes; D010455:Peptides; D019444:Vaccines, DNA; D014759:Viral Envelope Proteins; D015933:Complement C3d |
Papers featured in the World Journal of Gastroenterology from 2006 to 2007. | AIM
To analyze papers published in the World Journal of Gastroenterology (WJG) from 2006 to 2007. We investigated the highly cited papers for geographic distribution of the cited authors, as well as the distribution of the citing journals and year of citation.
METHODS
Papers published in WJG from 2006 to 2007 and the... | 10.3748/wjg.15.4471 | 19,764,106 | D000043:Abstracting and Indexing; D005762:Gastroenterology; D007391:International Cooperation; D055811:Journal Impact Factor; D010506:Periodicals as Topic; D011643:Publishing | World journal of gastroenterology | 2,009 | |
Autoimmune thyroid disease associated with environmental thyroidal irradiation. | Reports of increased rates of thyroid disease in populations exposed to radiation as a result of the Chernobyl accident have increased awareness and concern about the risk of autoimmune-related thyroid disease possibly associated with environmental radiation exposure. While the association between thyroidal irradiation... | 10.1089/105072503322021115 | 12,855,012 | D001327:Autoimmune Diseases; D015551:Autoimmunity; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure; D006801:Humans; D011832:Radiation Injuries; D018788:Radioactive Hazard Release; D013959:Thyroid Diseases | Thyroid : official journal of the American Thyroid Association | 2,003 | |
Distinct effects of CD86-mediated costimulation on resting versus activated human CD4+ T cells. | CD80 and CD86 are important in the initiation of T cell immunity. Although their costimulatory function has long been appreciated, it remains unclear whether the biological significance of the two B7 isoforms resides in their different patterns and kinetics of expression or whether differences exist in their function. ... | 10.1002/eji.200526199 | 16,180,251 | D015703:Antigens, CD; D000943:Antigens, Differentiation; D018122:B7-1 Antigen; D015496:CD4-Positive T-Lymphocytes; D060908:CTLA-4 Antigen; D002460:Cell Line; D005434:Flow Cytometry; D015798:HLA-DR1 Antigen; D006801:Humans; D008213:Lymphocyte Activation; D014162:Transfection | European journal of immunology | 2,005 | D015703:Antigens, CD; D000943:Antigens, Differentiation; D018122:B7-1 Antigen; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D015798:HLA-DR1 Antigen |
Gait parameters and stride-to-stride variability during familiarization to walking on a split-belt treadmill. | BACKGROUND
Subjects unfamiliar to walking on a split-belt treadmill may initially demonstrate an altered gait pattern or increased variability of gait parameters. While previous investigations have examined kinematic variables associated with familiarization time, the objective of this study was to determine the famili... | 10.1016/j.clinbiomech.2009.11.002 | 20,004,501 | D000222:Adaptation, Physiological; D000328:Adult; D005080:Exercise Test; D005260:Female; D005684:Gait; D006801:Humans; D007858:Learning; D007866:Leg; D008124:Locomotion; D008297:Male; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical | Clinical biomechanics (Bristol, Avon) | 2,010 | |
Plasma oxytocin concentrations during the menstrual cycle in the rhesus monkey, Macaca mulatta. | Plasma samples were obtained from 8 conscious rhesus monkeys at 3-4 day intervals throughout the menstrual cycle. Oxytocin concentrations were significantly higher in mid-cycle (Days 10-11) than at Days 4-5 (P < 0.01) and Days 28-29 (P < 0.02, Wilcoxon signed rank test). No significant correlations between oxytocin and... | 10.1530/jrf.0.0590069 | 6,772,779 | D000818:Animals; D004958:Estradiol; D004971:Estrus; D005260:Female; D000882:Haplorhini; D008251:Macaca; D008253:Macaca mulatta; D010121:Oxytocin; D011247:Pregnancy; D011374:Progesterone | Journal of reproduction and fertility | 1,980 | D011374:Progesterone; D004958:Estradiol; D010121:Oxytocin |
A 60-year journey of mycorrhizal research in China: Past, present and future directions. | The significance of mycorrhizas (fungal roots in 90% of land plants) in plant nutrient acquisition and growth, element biogeochemical cycling and maintaining of terrestrial ecosystem structures has been globally established for more than 120 years. Great progress in mycorrhizal research in the past 60 years (1950-2009,... | 10.1007/s11427-010-4096-z | 21,181,339 | D002681:China; D049673:History, 20th Century; D049674:History, 21st Century; D007113:Immunity, Innate; D038821:Mycorrhizae; D010506:Periodicals as Topic; D018517:Plant Roots; D012106:Research; D012988:Soil Microbiology | Science China. Life sciences | 2,010 | |
Cynometra cauliflora essential oils loaded-chitosan nanoparticles: Evaluations of their antioxidant, antimicrobial and cytotoxic activities. | Nanoencapsulation has appeared as an alternative approach to protect the bioactive constituents of essential oils (EOs) and to improve their properties. In this study, Cynometra cauliflora essential oils (CCEOs) were nanoencapsulated in chitosan nanoparticles (CSNPs) using an emulsion-ionic gelation technique. Transmis... | 10.1016/j.ijbiomac.2022.04.230 | 35,513,100 | D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D048271:Chitosan; D006801:Humans; D053758:Nanoparticles; D009822:Oils, Volatile; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared | International journal of biological macromolecules | 2,022 | D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D009822:Oils, Volatile; D048271:Chitosan |
When the patient wants facial cosmetic surgery. | Cosmetic facial surgery can improve appearance but it cannot make everyone beautiful (or handsome) or solve all problems. The patient must be well motivated and must comprehend the limitations of the procedures. Procedures useful in providing a more youthful appearance include blepharoplasty, browlift and face-lift. So... | 900,001 | D000328:Adult; D002615:Chemexfoliation; D004431:Ear, External; D005138:Eyebrows; D005143:Eyelids; D005145:Face; D005260:Female; D006197:Hair; D006801:Humans; D008297:Male; D008875:Middle Aged; D012225:Rhinoplasty; D013518:Surgery, Plastic; D014182:Transplantation, Autologous | American family physician | 1,977 | ||
TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma. | The molecular basis underlying nasopharyngeal carcinoma (NPC) remains unclear. Recent progress in transcriptional regulatory network analysis helps identify the master regulator (MR) proteins that transcriptionally define malignant tumor phenotypes. Here, we investigated transcription factor-target interactions and ide... | 10.1126/sciadv.add0960 | 36,608,137 | D006801:Humans; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002945:Cisplatin; D004268:DNA-Binding Proteins; D015972:Gene Expression Regulation, Neoplastic; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms; D000091262:TEA Domain Transcription Factors; D014157:Transcription Factors | Science advances | 2,023 | C568809:BZW2 protein, human; D002945:Cisplatin; D004268:DNA-Binding Proteins; D000091262:TEA Domain Transcription Factors; C486309:TEAD4 protein, human; D014157:Transcription Factors; C548241:NT5E protein, human; C035401:SS-A antigen |
Posterior vitreous detachment. | Posterior vitreous detachment is an expected consequence of aging, but it can also be the initiating cause of a retinal detachment. To understand the mechanism of posterior vitreous detachment and its sequelae, it is necessary to appreciate the anatomy of the vitreous, its development, and the pathogenesis of vitreous ... | 1,463,911 | D000375:Aging; D005128:Eye Diseases; D005654:Fundus Oculi; D006801:Humans; D012163:Retinal Detachment; D012167:Retinal Perforations; D014822:Vitreous Body; D014823:Vitreous Hemorrhage | Optometry clinics : the official publication of the Prentice Society | 1,992 | ||
Overview of naphthalimide analogs as anticancer agents. | Cancer, which accounted for 7.9 million deaths (around 13% of all deaths) in 2007, is a leading cause of death in the world. Deaths from cancer worldwide are projected to continue rising, with an estimated 12 million deaths in 2030. Therefore, the rapid increase in the cancer burden represents a real crisis for public ... | 10.2174/092986709789909576 | 19,929,786 | D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D006801:Humans; D053644:Naphthalimides; D009369:Neoplasms; D013329:Structure-Activity Relationship | Current medicinal chemistry | 2,009 | D000970:Antineoplastic Agents; D053644:Naphthalimides |
Beyond the moment: Influence of a co-facilitated education intervention on practitioners' recovery beliefs and practices. | Despite health policy and research increasingly advocating for recovery-enabling principles to be better integrated into mental health services, finding solutions to enhance the translation of recovery policy into practice remains a challenge. This study sought to understand whether a co-facilitated group education int... | 10.1111/inm.12740 | 32,462,739 | D003376:Counseling; D005190:Family; D006801:Humans; D008603:Mental Health; D008605:Mental Health Services; D011568:Psychiatric Nursing | International journal of mental health nursing | 2,020 | |
Identification of Reissner's fiber-like glycoproteins in two species of freshwater planarians (Tricladida), by use of specific polyclonal and monoclonal antibodies. | By using one polyclonal antiserum raised against bovine Reissner's fiber and seven monoclonal antibodies raised against bovine Reissner's fiber and against immunopurified bovine subcommissural organ glycoproteins, we have investigated two freshwater planarian species (Girardia tigrina, Schmidtea mediterranea) by light-... | 10.1007/s004410000211 | 10,928,273 | D000818:Animals; D000911:Antibodies, Monoclonal; D002417:Cattle; D015816:Cell Adhesion Molecules, Neuronal; D004797:Enzyme-Linked Immunosorbent Assay; D000078404:Epidermal Cells; D004817:Epidermis; D000939:Epitopes; D005618:Fresh Water; D016253:Microscopy, Immunoelectron; D010802:Phylogeny; D010932:Planarians; D013351:... | Cell and tissue research | 2,000 | D000911:Antibodies, Monoclonal; D015816:Cell Adhesion Molecules, Neuronal; D000939:Epitopes; C108402:SCO-spondin |
Clefts with associated anomalies and syndromes in Finland. | Probands with clefts born during an 11-year period, 1975-85, were evaluated; 1,586 probands were found of whom 345 (171 males and 174 females, 21.8%) had an associated anomaly. More male patients had cleft lips, with or without cleft palate (CL(P)) and more female patients had cleft palates (CP). The anomalies were sub... | 10.3109/02844319209016011 | 1,411,347 | D000015:Abnormalities, Multiple; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip; D002972:Cleft Palate; D005260:Female; D005387:Finland; D006801:Humans; D008297:Male; D013577:Syndrome | Scandinavian journal of plastic and reconstructive surgery and hand surgery | 1,992 | |
Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. | A gene bank of partial Sau3A restriction fragments of S. pombe DNA has been constructed in the plasmid vector, pDB248', which is capable of high frequency transformation of S. pombe. Procedures are described which enable plasmids to be recovered from S. pombe by their reintroduction into E. coli. These methods have bee... | 10.1007/BF00331138 | 6,294,466 | D001203:Ascomycota; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004271:DNA, Fungal; D004274:DNA, Recombinant; D004926:Escherichia coli; D005816:Genetic Complementation Test; D005822:Genetic Vectors; D010957:Plasmids; D012568:Schizosaccharomyces; D014170:Transformation, Genetic | Molecular & general genetics : MGG | 1,982 | D004271:DNA, Fungal; D004274:DNA, Recombinant; D004262:DNA Restriction Enzymes |
Clinical trial design for mild-to-moderate community-acquired pneumonia--an industry perspective. | The use of noninferiority clinical trials is problematic unless one can establish the benefit of the active control versus no treatment. In community-acquired pneumonia, there are no placebo-controlled clinical trials establishing the benefit of antibiotic treatment, because the observed benefit of sulfapyridine and, s... | 10.1086/591399 | 18,986,284 | D000900:Anti-Bacterial Agents; D002986:Clinical Trials as Topic; D017714:Community-Acquired Infections; D006801:Humans; D018410:Pneumonia, Bacterial; D011018:Pneumonia, Pneumococcal; D012107:Research Design; D016896:Treatment Outcome | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 2,008 | D000900:Anti-Bacterial Agents |
Species-specific rewiring of definitive endoderm developmental gene activation via endogenous retroviruses through TET1-mediated demethylation. | Transposable elements (TEs) are the major sources of lineage-specific genomic innovation and comprise nearly half of the human genome, but most of their functions remain unclear. Here, we identify that a series of endogenous retroviruses (ERVs), a TE subclass, regulate the transcriptome at the definitive endoderm stage... | 10.1016/j.celrep.2022.111791 | 36,516,776 | D000818:Animals; D006801:Humans; D020077:Endogenous Retroviruses; D004707:Endoderm; D015533:Transcriptional Activation; D011323:Primates; D050437:Genes, Developmental; D000073398:Demethylation; D006899:Mixed Function Oxygenases; D011518:Proto-Oncogene Proteins | Cell reports | 2,022 | C462539:TET1 protein, human; D006899:Mixed Function Oxygenases; D011518:Proto-Oncogene Proteins |
Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors. | Alterations in the pattern of keratin expression are a common feature of skin-tumor development. In this study, we investigated whether the loss of epidermal keratin 1 (K1) and its replacement by mucosal keratin 13 (K13) is unique to mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecan... | 10.1002/mc.2940070207 | 7,681,292 | D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell; D002610:Cheek; D006224:Cricetinae; D004273:DNA, Neoplasm; D011905:Genes, ras; D007124:Immunoenzyme Techniques; D007633:Keratins; D008297:Male; D008647:Mesocricetus; D008969:Molecular Sequence Data; D01021... | Molecular carcinogenesis | 1,993 | D004273:DNA, Neoplasm; D015127:9,10-Dimethyl-1,2-benzanthracene; D007633:Keratins |
Antigenic studies on an enzymatically sialylated carbohydrate: NeuAc(alpha 2-3)Gal(beta 1-3)[GlcNAc(beta 1-6)]GalNAc. | The CA 125 antigenic determinant has been shown to be elevated in the serum of ovarian cancer patients and is a useful prognostic marker. The chemical epitope which characterizes the CA 125 antigen is found on a high molecular weight glycoprotein and has been suggested to be carbohydrate in nature. This study was under... | 10.3109/08820139109054922 | 2,055,602 | D000818:Animals; D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D002240:Carbohydrate Sequence; D003429:Cross Reactions; D005260:Female; D006041:Goats; D008969:Molecular Sequence Data; D019158:N-Acetylneuraminic Acid; D009844:Oligosaccharides; D011817:Rabbits; D012661:Semen; D012710:Se... | Immunological investigations | 1,991 | D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D009844:Oligosaccharides; D012794:Sialic Acids; D014312:Trisaccharides; C069500:N-acetylneuraminyl(2-3)galactosyl(1-3)-N-acetylglucosyl(1-6)-N-acetylgalactose; D012710:Serum Albumin, Bovine; D019158:N-Acetylneuraminic Acid |
Onychomycosis: successful treatment with once-weekly fluconazole. | We report a case of fingernail onychomycosis in an immunosuppressed renal transplant patient who was successfully treated with once-weekly fluconazole therapy. Relapse did not develop over the 2-month follow-up period. There were no adverse effects from therapy and the cyclosporin dose did not require adjustment. This ... | 10.1159/000247304 | 8,435,519 | D004334:Drug Administration Schedule; D005260:Female; D015725:Fluconazole; D005500:Follow-Up Studies; D006229:Hand Dermatoses; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D014009:Onychomycosis; D012074:Remission Induction | Dermatology (Basel, Switzerland) | 1,993 | D015725:Fluconazole |
Optimizing diabetic kidney disease animal models: Insights from a meta-analytic approach. | Diabetic kidney disease (DKD) is a prevalent complication of diabetes, often leading to end-stage renal disease. Animal models have been widely used to study the pathogenesis of DKD and evaluate potential therapies. However, current animal models often fail to fully capture the pathological characteristics of renal inj... | 10.1002/ame2.12350 | 37,723,622 | D006801:Humans; D000818:Animals; D003928:Diabetic Nephropathies; D015203:Reproducibility of Results; D007668:Kidney; D007677:Kidney Function Tests; D007676:Kidney Failure, Chronic; D003920:Diabetes Mellitus | Animal models and experimental medicine | 2,023 | |
The role of oxygen defects in the electronic, optical and phonon dispersion of the LAGO perovskite: a density functional theory investigation. | The study aims to investigate the electronic, optical and phonon dispersion properties of a pure and 2.5% O-defect induced LAGO perovskite, using density functional theory (DFT) with generalized gradient approximation (GGA) and the PBE functional. The research reveals a significant reduction in the band gap from 3.27 e... | 10.1039/d3dt02846a | 37,930,338 | Dalton transactions (Cambridge, England : 2003) | 2,023 | ||
IL-13Rα1 expression on β-cell-specific T cells in NOD mice. | OBJECTIVE
Immunotherapy using peptides from the β-cell antigen GAD65 can preserve glucose homeostasis in diabetes-prone NOD mice; however, the precise mechanisms that arrest islet-reactive T cells remain unresolved. Our previous work revealed that a dominant GAD65 epitope contained two overlapping I-A(g7)-restricted de... | 10.2337/db10-1229 | 21,617,187 | D000818:Animals; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes; D002460:Cell Line; D049109:Cell Proliferation; D004797:Enzyme-Linked Immunosorbent Assay; D058501:Enzyme-Linked Immunospot Assay; D005260:Female; D005434:Flow Cytometry; D005968:Glutamate Decarboxylase; D006801:Humans; D050417:Insulin-Secreting ... | Diabetes | 2,011 | D018793:Interleukin-13; D053661:Interleukin-13 Receptor alpha1 Subunit; D010446:Peptide Fragments; D050800:STAT6 Transcription Factor; D007371:Interferon-gamma; C439755:GAD65 (524-543); D005968:Glutamate Decarboxylase |
Functionalization through lithiation of (S)-N-(1-phenylpropyl)-2-phenylquinoline-4-carboxamide. Application to the labeling with carbon-11 of NK-3 receptor antagonist SB 222200. | Lithiation of (S)-N-(1-phenylpropyl)-2-phenylquinoline-4-carboxamide with the complex n-BuLi/TMEDA (1/1 molar ratio) in THF at -60 degrees C for 5 h occurred selectively at the position 3 of the quinoline ring. This selectivity was shown by the absence of racemization of the stereogenic center and the formation of the ... | 10.1021/jo062285p | 17,319,724 | D000577:Amides; D000818:Animals; D002250:Carbon Radioisotopes; D002417:Cattle; D007553:Isotope Labeling; D008094:Lithium; D011804:Quinolines; D018042:Receptors, Neurokinin-3 | The Journal of organic chemistry | 2,007 | D000577:Amides; D002250:Carbon Radioisotopes; D011804:Quinolines; D018042:Receptors, Neurokinin-3; C109112:SB 222200; D008094:Lithium |
A protective role for CD154 in hepatic steatosis in mice. | UNLABELLED
Inflammation and lipid metabolism pathways are linked, and deregulation of this interface may be critical in hepatic steatosis. The importance of the dialog between inflammatory signaling pathways and the unfolded protein response (UPR) in metabolism has been underlined. Herein, we studied the role of CD154,... | 10.1002/hep.23935 | 21,064,031 | D000818:Animals; D053299:Apolipoprotein B-100; D023201:CD40 Ligand; D002478:Cells, Cultured; D005234:Fatty Liver; D056945:Hep G2 Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D019301:Oleic Acid; D056811:Unfolded Protein Response | Hepatology (Baltimore, Md.) | 2,010 | D053299:Apolipoprotein B-100; D023201:CD40 Ligand; D019301:Oleic Acid |
Three-dimensional evaluation of the mandibular third molars' development in unilateral crossbite patients: A cone beam computed tomography study. | OBJECTIVES
The aim was to investigate mandibular third molar (3M)'s maturation in the crossbite and normal sides by two- and three-dimensional analyses using cone beam computed tomography (CBCT).
MATERIALS AND METHODS
A retrospective study was performed using CBCT of 25 patients (16 females and 9 males; mean age: 16.... | 10.4103/1305-7456.137653 | 25,202,221 | European journal of dentistry | 2,014 | ||
[Patient-reported clinical trial endpoints--the current state of affairs in research and practice]. | Patient-reported outcomes are increasingly considered as endpoints for clinical studies. Instruments for measuring patient-reported outcomes range from simple assessments of discrete symptoms or signs to complex measures addressing multidimensional constructs such as health-related quality of life. While generic measur... | 10.1016/j.zefq.2010.03.014 | 20,608,256 | D002986:Clinical Trials as Topic; D006801:Humans; D017063:Outcome Assessment, Health Care; D010361:Patients; D011369:Professional-Patient Relations; D011788:Quality of Life; D012106:Research; D012107:Research Design; D016896:Treatment Outcome | Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen | 2,010 | |
ALFRED: An allele frequency database for anthropology. | The deluge of data from the human genome project (HGP) presents new opportunities for molecular anthropologists to study human variation through the promise of vast numbers of new polymorphisms (e.g., single nucleotide polymorphisms or SNPs). Collecting the resulting data into a single, easily accessible resource will ... | 10.1002/ajpa.10094 | 12,209,575 | D000885:Anthropology, Physical; D016208:Databases, Factual; D005787:Gene Frequency; D016045:Human Genome Project; D006801:Humans; D020407:Internet; D011110:Polymorphism, Genetic | American journal of physical anthropology | 2,002 | |
Nuclear localization and shuttling of herpes simplex virus tegument protein VP13/14. | The herpes simplex virus type 1 gene UL47 encodes the tegument proteins referred to collectively as VP13/14, which are believed to be differentially modified forms of the same protein. Here we show that the major product of the UL47 gene during transient expression is VP14, suggesting that some feature of virus infecti... | 10.1128/JVI.75.6.2566-2574.2001 | 11,222,679 | D016475:3T3 Cells; D021581:Active Transport, Cell Nucleus; D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002467:Cell Nucleus; D002522:Chlorocebus aethiops; D049452:Green Fluorescent Proteins; D006561:Herpes Simplex; D018259:Herpesvirus 1, Human; D008164:Luminescent Proteins; D051379:Mice; D008969:Mo... | Journal of virology | 2,001 | D008164:Luminescent Proteins; D019913:Nuclear Localization Signals; D011993:Recombinant Fusion Proteins; C085822:VP13-14 protein, herpes simplex virus type 1; D014760:Viral Fusion Proteins; D049452:Green Fluorescent Proteins |
Valve-in-Valve Transcatheter Aortic Valve Implantation With Acute Left and Right Coronary Artery Occlusion: A Case Report. | Acute coronary artery occlusion is a relatively rare procedural adverse event in valve-in-valve transcatheter aortic valve implantation. Here we present a case of a 26-mm Sapien 3 prosthetic valve implantation in a degenerated 23-mm Freedom Solo bioprosthetic surgical valve with subsequent left and right coronary occlu... | 10.14740/jmc3868 | 35,464,332 | Journal of medical cases | 2,022 | ||
Caesarean section--an appraisal of some predictive factors in Lagos Nigeria. | BACKGROUND
Several maternity units in the developing world lack facilities for caesarean section and often have to transfer patients in extremis. This case controlled study aimed to appraise predictive factors for caesarean section.
METHODS
One hundred and fifty two consecutive women with singleton pregnancies who ha... | 10.1186/1471-2393-14-217 | 24,981,086 | D000328:Adult; D001724:Birth Weight; D001827:Body Height; D001835:Body Weight; D016022:Case-Control Studies; D002585:Cesarean Section; D017604:Cesarean Section, Repeat; D003906:Developing Countries; D005260:Female; D006801:Humans; D009549:Nigeria; D010298:Parity; D011247:Pregnancy; D011248:Pregnancy Complications; D011... | BMC pregnancy and childbirth | 2,014 | |
Case report. Erythrasmoid pityriasis versicolor. | A 50-year-old Caucasian man with pityriasis versicolor that was localized almost exclusively in the inguinal folds and was characterized by lesions clinically superimposable on those of erythrasma is described. Due to these clinical characteristics, it is proposed that this variety of pityriasis versicolor is defined a... | 10.1046/j.1439-0507.2001.00647.x | 11,820,268 | D000935:Antifungal Agents; D004894:Erythrasma; D006801:Humans; D017964:Itraconazole; D008290:Malassezia; D008297:Male; D008875:Middle Aged; D014010:Tinea Versicolor; D016896:Treatment Outcome | Mycoses | 2,001 | D000935:Antifungal Agents; D017964:Itraconazole |
Slow waves during sleep in crayfish. Origin and spread. | Previous results show that when unrestrained crayfish sleep, the electrical activity of the brain changes from multiple spikes (frequencies above 300 Hz) on a flat baseline to continuous slow waves at a frequency of 15-20 Hz. To study the temporal organization of such activity, we developed a tethered crayfish preparat... | 10.1242/jeb.038240 | 20,511,530 | D000818:Animals; D003400:Astacoidea; D001921:Brain; D001931:Brain Mapping; D016000:Cluster Analysis; D055724:Electrophysiological Phenomena; D005074:Evoked Potentials, Visual; D008297:Male; D012890:Sleep; D014851:Wakefulness | The Journal of experimental biology | 2,010 | |
Schizophrenic subjects show deficient inhibition but intact task switching on saccadic tasks. | BACKGROUND
Schizophrenic patients have executive function deficits, presumably on the basis of prefrontal cortex dysfunction. Although they consistently show impaired inhibition, the evidence of a task switching deficit is less consistent and is often based on performance of neuropsychological tests that require severa... | 10.1016/s0006-3223(01)01356-7 | 12,007,456 | D000328:Adult; D014150:Antipsychotic Agents; D003072:Cognition Disorders; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net; D009433:Neural Inhibition; D009483:Neuropsychological Tests; D011897:Random Allocation; D012438:Saccades; D012559:Schizophrenia; D013647:Task Performance and Analysis | Biological psychiatry | 2,002 | D014150:Antipsychotic Agents |
Enzymes, metabolites and fluxes. | Aspects of metabolic control theory and experiments from metabolic biochemistry are reviewed in order to deduce the circumstances in which experimental studies involving metabolomics have the greatest chance of success. It is concluded that metabolic changes effected mainly through a single enzyme are those most likely... | 10.1093/jxb/eri011 | 15,545,297 | D004798:Enzymes; D015971:Gene Expression Regulation, Enzymologic; D018506:Gene Expression Regulation, Plant; D008954:Models, Biological; D010944:Plants | Journal of experimental botany | 2,005 | D004798:Enzymes |
Genetic control of resistance to Coccidioides immitis: a single gene that is expressed in spleen cells determines resistance. | We have previously reported that inbred mice vary widely in their resistance to Coccidioides immitis peritonitis. To investigate the number of genes controlling resistance, (susceptible X resistant)F1 X susceptible backcross mice were tested for resistance to infection. A 1:1 ratio of resistant:susceptible offspring wa... | 3,998,472 | D000818:Animals; D003045:Coccidioides; D003047:Coccidioidomycosis; D005260:Female; D005800:Genes, Fungal; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D... | Journal of immunology (Baltimore, Md. : 1950) | 1,985 | ||
An important role for major histocompatibility complex class I-restricted T cells, and a limited role for gamma interferon, in protection of mice against lethal herpes simplex virus infection. | Herpes simplex virus (HSV) inhibits major histocompatibility complex (MHC) class I expression in infected cells and does so much more efficiently in human cells than in murine cells. Given this difference, if MHC class I-restricted T cells do not play an important role in protection of mice from HSV, an important role ... | 10.1128/JVI.73.3.2058-2063.1999 | 9,971,787 | D000818:Animals; D000914:Antibodies, Viral; D016207:Cytokines; D006561:Herpes Simplex; D015395:Histocompatibility Antigens Class I; D007371:Interferon-gamma; D008213:Lymphocyte Activation; D051379:Mice; D018345:Mice, Knockout; D013601:T-Lymphocytes | Journal of virology | 1,999 | D000914:Antibodies, Viral; D016207:Cytokines; D015395:Histocompatibility Antigens Class I; D007371:Interferon-gamma |
Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure. | Parkinson's disease (PD), which is characterized by degeneration of mesencephalic dopaminergic neurons of unclear etiology, is primarily an age-related neurodegenerative disorder, while the normal process of aging is also known to decrease the number of dopaminergic neurons in the substantia nigra pars compacta (SNc) a... | 10.1016/j.brainres.2011.01.056 | 21,276,773 | D000375:Aging; D000818:Animals; D004298:Dopamine; D005526:Food, Formulated; D005966:Glucuronidase; D000090265:Klotho Proteins; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D009410:Nerve Degeneration; D010300:Parkinson Disease; ... | Brain research | 2,011 | D014807:Vitamin D; D005966:Glucuronidase; D000090265:Klotho Proteins; D004298:Dopamine |
Alterations of short-term heart rate variability in periinduction period of general anaesthesia with two intravenous anaesthetics. | INTRODUCTION
Alterations of the parameters of heart rate variability, phenomenon associated with autonomic nervous system balance, have been shown as a possibly very important factor for monitoring of cardiocirculatory system in the perioperative period. Periinduction period of general anaesthesia is very important wit... | 10.5455/medarh.2013.67.233-236 | 24,520,741 | D018686:Anesthetics, Intravenous; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D015742:Propofol; D013874:Thiopental | Medical archives (Sarajevo, Bosnia and Herzegovina) | 2,013 | D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol |
The impact and cost-effectiveness of combined HIV prevention scenarios among transgender women sex-workers in Lima, Peru: a mathematical modelling study. | BACKGROUND
HIV incidence remains high among transgender women in Lima, Peru, most of whom report sex work. On the basis of a stakeholder analysis and health system capacity assessment, we designed a mathematical model to guide HIV programmatic planning among transgender women sex workers (TWSW) in Lima.
METHODS
Using... | 10.1016/S2468-2667(18)30236-6 | 30,683,587 | D003362:Cost-Benefit Analysis; D005260:Female; D015658:HIV Infections; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D010568:Peru; D011314:Preventive Health Services; D015397:Program Evaluation; D060386:Sex Workers; D063106:Transgender Persons | The Lancet. Public health | 2,019 | |
XRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma. | The association between DNA repair gene polymorphisms and bladder cancer has been widely studied. However, few studies have examined the correlation between urothelial carcinoma (UC) and arsenic or its metabolites. The aim of this study was to examine the association between polymorphisms of the DNA repair genes, XRCC1... | 10.1016/j.taap.2014.06.027 | 25,018,058 | D000368:Aged; D001151:Arsenic; D002101:Cacodylic Acid; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D016001:Confidence Intervals; D004247:DNA; D004260:DNA Repair; D004268:DNA-Binding Proteins; D004781:Environmental Exposure; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; ... | Toxicology and applied pharmacology | 2,014 | D004268:DNA-Binding Proteins; D011042:Poisons; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human; D004247:DNA; D002101:Cacodylic Acid; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human; D001151:Arsenic |
Inhibition of metamorphosis in tadpoles of Xenopus laevis exposed to polybrominated diphenyl ethers (PBDEs). | Tadpoles of the African clawed frog, Xenopus laevis were exposed, beginning at stage 50, to a commercial pentabromodiphenyl ether mixture (DE-71) through the diet. Subsequent experiments were conducted using a single intraperitoneal injection at stage 58 with limited quantities of two purified brominated diphenyl ether... | 10.1016/j.chemosphere.2005.12.019 | 16,455,129 | D000284:Administration, Oral; D000818:Animals; D001822:Body Burden; D005411:Flame Retardants; D007274:Injections, Intraperitoneal; D007814:Larva; D008675:Metamorphosis, Biological; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; D014874:Water Pollutants, Chemical; D014982:Xenopus laevis | Chemosphere | 2,006 | D005411:Flame Retardants; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; D014874:Water Pollutants, Chemical |
Eye movements of vertebrates and their relation to eye form and function. | The types of eye movements shown by all vertebrates originated in the earliest fishes. These consisted of compensatory movements, both vestibular and visual, to prevent image motion, and saccades to relocate gaze. All vertebrates fixate food items with their heads to enable ingestion, but from teleosts onwards some spe... | 10.1007/s00359-014-0964-5 | 25,398,576 | D000818:Animals; D005123:Eye; D005133:Eye Movements; D019416:Head Movements; D006801:Humans; D012018:Reflex; D015348:Vision, Binocular | Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology | 2,015 | |
Fluid leakage across tracheal tube cuff, effect of different cuff material, shape, and positive expiratory pressure: a bench-top study. | PURPOSE
Standard polyvinylchloride (PVC) endotracheal tube (ETT) cuffs do not protect from aspiration across the cuff, a leading cause of ventilator-associated pneumonia (VAP). In a long-lasting in vitro study we compared the effect of different cuff materials (PVC, polyurethane, and guayule latex), shapes (cylindrical... | 10.1007/s00134-010-2106-z | 21,152,894 | D004867:Equipment Design; D004868:Equipment Failure; D006801:Humans; D007442:Intubation, Intratracheal; D010969:Plastics; D011175:Positive-Pressure Respiration | Intensive care medicine | 2,011 | D010969:Plastics |
Behavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents. | OBJECTIVE
Anger, irritability, and aggression are among the most common reasons for child mental health referrals. This review is focused on two forms of behavioral interventions for these behavioral problems: Parent management training (PMT) and cognitive-behavioral therapy (CBT).
METHODS
First, we provide an overvi... | 10.1089/cap.2015.0120 | 26,745,682 | D000293:Adolescent; D000374:Aggression; D000786:Anger; D019958:Attention Deficit and Disruptive Behavior Disorders; D002648:Child; D002653:Child Behavior Disorders; D015928:Cognitive Behavioral Therapy; D006801:Humans; D007508:Irritable Mood; D010290:Parents | Journal of child and adolescent psychopharmacology | 2,016 | |
Neonatal thyroxine activation modifies epigenetic programming of the liver. | The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific Dio2 inactivation (Alb-D2KO) transiently increases H3K9me3 levels dur... | 10.1038/s41467-021-24748-8 | 34,290,257 | D000818:Animals; D000831:Animals, Newborn; D002843:Chromatin; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D007453:Iodide Peroxidase; D008099:Liver; D051379:Mice; D018345:Mice, Knockout; D014284:Triiodothyronine; D000097564:Iodothyroni... | Nature communications | 2,021 | D002843:Chromatin; D014284:Triiodothyronine; D007453:Iodide Peroxidase |
Motion-compensated gradient waveforms for tensor-valued diffusion encoding by constrained numerical optimization. | PURPOSE
Diffusion-weighted MRI is sensitive to incoherent tissue motion, which may confound the measured signal and subsequent analysis. We propose a "motion-compensated" gradient waveform design for tensor-valued diffusion encoding that negates the effects bulk motion and incoherent motion in the ballistic regime.
M... | 10.1002/mrm.28551 | 33,048,401 | D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging; D006321:Heart; D007091:Image Processing, Computer-Assisted; D009038:Motion | Magnetic resonance in medicine | 2,021 | |
Lessons from Hurricane Ida: Addressing gaps in emergency preparedness planning to protect residents in independent living facilities. | This paper describes how Hurricane Ida exposed gaps in emergency preparedness planning and coordination in New Orleans, particularly related to the health and safety of the residents of multi-storey independent living facilities designated for seniors and persons with disabilities, where at least ten lives were lost du... | 37,537,759 | D006801:Humans; D002959:Civil Defense; D004189:Disaster Planning; D057187:Independent Living; D055867:Cyclonic Storms | Journal of business continuity & emergency planning | 2,023 | ||
The role of task-related learned representations in explaining asymmetries in task switching. | Task switch costs often show an asymmetry, with switch costs being larger when switching from a difficult task to an easier task. This asymmetry has been explained by difficult tasks being represented more strongly and consequently requiring more inhibition prior to switching to the easier task. The present study shows... | 10.1371/journal.pone.0061729 | 23,613,919 | D001288:Attention; D004193:Discrimination Learning; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance; D011930:Reaction Time | PloS one | 2,013 | |
Carboxymethyl chitosan-TK resistant starch complex ameliorates type 2 diabetes by regulating the gut microbiota. | Carboxymethyl chitosan and resistant starch exhibit good performance in diabetes regulation. We prepared carboxymethyl chitosan - resistant starch complex. Test the properties of composite resistant starch by using X-ray diffraction, water contact angle, infrared spectroscopy, and scanning electron microscopy, interact... | 10.1016/j.ijbiomac.2023.126930 | 37,717,867 | D000818:Animals; D051379:Mice; D000069196:Gastrointestinal Microbiome; D000084922:Resistant Starch; D003924:Diabetes Mellitus, Type 2; D013213:Starch; D048271:Chitosan; D003921:Diabetes Mellitus, Experimental | International journal of biological macromolecules | 2,023 | D000084922:Resistant Starch; D013213:Starch; D048271:Chitosan |
Micronization of gemfibrozil by reactive precipitation process. | Ultrafine gemfibrozil (GEM) was prepared by reactive precipitation process in which methyl cellulose (MC) was employed to inhibit the growth and the agglomeration of particles. The impact of NaOH concentrations on bulk GEM consumption was explored. The effects of H2SO4 concentrations and the drying methods on the parti... | 10.1016/j.ijpharm.2008.04.026 | 18,502,064 | D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003890:Desiccation; D005079:Excipients; D015248:Gemfibrozil; D000960:Hypolipidemic Agents; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders; D012972:Sodium Hydroxide; D012995:Solubility; D017550:Spectroscopy,... | International journal of pharmaceutics | 2,008 | D005079:Excipients; D000960:Hypolipidemic Agents; D011208:Powders; D013464:Sulfuric Acids; D012972:Sodium Hydroxide; D015248:Gemfibrozil |
Combination of pegylated interferon and lamivudine for patients with chronic hepatitis B who have failed treatment. | BACKGROUND
Treatment of chronic hepatitis B (CHB) alone with interferon or lamivudine alone or in combination is effective in only a small proportion of patients. Treatment of patients in whom antiviral therapy fails is challenging. This study was made to determine the efficacy of combined pegylated interferon alpha (p... | 16,911,934 | D000328:Adult; D000410:Alanine Transaminase; D000998:Antiviral Agents; D001706:Biopsy; D004279:DNA, Viral; D004359:Drug Therapy, Combination; D005260:Female; D019694:Hepatitis B, Chronic; D006801:Humans; D016898:Interferon-alpha; D019259:Lamivudine; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D0168... | Hepatobiliary & pancreatic diseases international : HBPD INT | 2,006 | D000998:Antiviral Agents; D004279:DNA, Viral; D016898:Interferon-alpha; D019259:Lamivudine; D011092:Polyethylene Glycols; D000410:Alanine Transaminase | |
Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects? | During development hematopoietic stem cells (HSCs) expand in number and persist throughout life by undergoing self-renewing divisions. Nevertheless, the hematopoietic system does not escape the negative effects of aging, suggesting that self-renewal is not complete. A fundamental issue in stem cell biology relates to s... | 10.1016/j.coi.2011.05.006 | 21,664,115 | D017668:Age of Onset; D000368:Aged; D000375:Aging; D000818:Animals; D001853:Bone Marrow; D019070:Cell Lineage; D002999:Clone Cells; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D006413:Hematopoietic System; D006801:Humans; D007951:Leukemia, Myeloid; D008214... | Current opinion in immunology | 2,011 | |
Association of Compartmental Bone Bruise Distribution With Concomitant Intra-articular and Extra-articular Injuries in Acute Anterior Cruciate Ligament Tears After Noncontact Sports Trauma. | BACKGROUND
Anterior cruciate ligament (ACL) injuries are frequently associated with bone bruises, and their presence may be associated with concomitant intra- and extra-articular injuries.
PURPOSE
To investigate the prevalence and pattern of distribution of bone bruises in patients with acute ACL tears from noncontac... | 10.1177/2325967118767625 | 29,780,838 | Orthopaedic journal of sports medicine | 2,018 | ||
Prevalence and genotyping pattern of hepatitis C virus among patients on maintenance hemodialysis at five centers in Pune, India. | BACKGROUND
Worldwide prevalence of Hepatitis C virus (HCV) infection hemodialysis (HD) ranges from 1 to 84.6% with serious complications. Assessment of prevalence, risk factors, and genotyping of HCV infection in patient on HD was carried out at Pune, India.
METHODS
A total of 250 patients on HD from five HD centers ... | 10.1016/j.mjafi.2018.08.001 | 30,705,482 | Medical journal, Armed Forces India | 2,019 | ||
Diabetes induces remodeling of the left atrial appendage independently of atrial fibrillation in a rodent model of type-2 diabetes. | BACKGROUND
Diabetic patients have an increased predisposition to thromboembolic events, in most cases originating from thrombi in the left atrial appendage (LAA). Remodeling of the LAA, which predisposes to thrombi formation, has been previously described in diabetic patients with atrial fibrillation, but whether remod... | 10.1186/s12933-021-01347-x | 34,301,258 | D000818:Animals; D020517:Atrial Appendage; D016279:Atrial Function, Left; D064752:Atrial Remodeling; D003924:Diabetes Mellitus, Type 2; D058065:Diabetic Cardiomyopathies; D004195:Disease Models, Animal; D018450:Disease Progression; D018618:Echocardiography, Doppler, Color; D006003:Glycogen; D006339:Heart Rate; D008297:... | Cardiovascular diabetology | 2,021 | D006003:Glycogen |
Bovine leukemia virus genotype surveillance in cattle at a slaughterhouse in Aichi Prefecture, Japan, in 2019 using polymerase chain reaction combined with restriction fragment length polymorphism. | Polymerase chain reaction (PCR) combined with restriction fragment length polymorphism (RFLP) is commonly used for genotyping bovine leukemia virus (BLV) in slaughterhouses. However, unclassified BLV genotypes have been sporadically reported. To assess the current status of BLV genetic characterization in cattle, PCR-R... | 10.1292/jvms.21-0234 | 34,544,937 | D000003:Abattoirs; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D016583:Enzootic Bovine Leukosis; D005838:Genotype; D007564:Japan; D001909:Leukemia Virus, Bovine; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length | The Journal of veterinary medical science | 2,021 | |
Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case report. | PURPOSE
To report the first known case of Descemet's Membrane Endothelial Keratoplasty (DMEK) graft rejection following COVID19 infection.
OBSERVATION
A 60-year-old woman with a history of DMEK for Fuch's dystrophy, presented with redness and vision loss in her operated eye 18 months after surgery. Further clinical h... | 10.1016/j.ajoc.2021.101138 | 34,151,048 | American journal of ophthalmology case reports | 2,021 | ||
Establishing the psychometric properties of a scale for evaluating quality in printed education materials. | A study establishing the psychometric properties of a quality standard for quantifying the presence (or absence) of instructional design/learning principles contained in printed education materials (PEMs) was conducted in 4 phases. Content validity, a pretest which included creation of a rating key, inter-rater reliabi... | 10.1016/s0738-3991(96)00927-5 | 9,006,244 | D006801:Humans; D015588:Observer Variation; D010353:Patient Education as Topic; D011594:Psychometrics; D015203:Reproducibility of Results; D013664:Teaching Materials | Patient education and counseling | 1,996 | |
A single tissue culture system for the propagation of the agents of the human ehrlichioses. | Two newly emergent human diseases found in the United States, human monocytotropic ehrlichiosis (HME) and human granulocytotropic ehrlichiosis (HGE), are caused by pathogens of the genus Ehrlichia. The causative agent of HGE can be propagated in HL-60 human promyelocytic leukemia cells. Herein, we report the developmen... | 10.4269/ajtmh.1998.58.812 | 9,660,470 | D000818:Animals; D002460:Cell Line; D018920:Coculture Techniques; D004269:DNA, Bacterial; D004285:Dogs; D004536:Ehrlichia; D018469:Ehrlichia chaffeensis; D016873:Ehrlichiosis; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute; D008264:Macrophages; D016133:Polymerase Chain Reaction; D014407:Tumor Cells, Cultured | The American journal of tropical medicine and hygiene | 1,998 | D004269:DNA, Bacterial |
Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use Is Related to Glutamate and GABA Concentrations in the Striatum But Not the Anterior Cingulate Cortex. | BACKGROUND
3,4-Methylenedioxymethamphetamine (MDMA) is a widely used recreational substance inducing acute release of serotonin. Previous studies in chronic MDMA users demonstrated selective adaptations in the serotonin system, which were assumed to be associated with cognitive deficits. However, serotonin functions ar... | 10.1093/ijnp/pyad023 | 37,235,749 | D051381:Rats; D000818:Animals; D018698:Glutamic Acid; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D009682:Magnetic Resonance Spectroscopy; D012701:Serotonin; D006179:Gyrus Cinguli; D005680:gamma-Aminobutyric Acid; D005973:Glutamine | The international journal of neuropsychopharmacology | 2,023 | D018698:Glutamic Acid; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D005973:Glutamine |
Longitudinal variations of characteristic frequencies of skeletal muscle fibre potentials detected by a bipolar electrode or multi-electrode. | We aimed to reveal reasons for longitudinal variations of characteristic frequencies of electromyographic signals detected by surface longitudinal multi-electrodes. Since the terminal phases were reduced in bipolar recordings, we tested whether the frequency variations reflected the effects of the excitation origin and... | 10.1080/03091900010022201 | 11,345,099 | D004576:Electromyography; D005071:Evoked Potentials; D006801:Humans; D018482:Muscle, Skeletal | Journal of medical engineering & technology | 2,001 | |
Comparison of Minimally Invasive Versus Open Transforaminal Interbody Lumbar Fusion. | STUDY DESIGN
Narrative review.
OBJECTIVES
In this review, we address the question of whether the literature supports the notion that minimally invasive transforaminal interbody fusion (MIS-TLIF) improves outcome as compared with open TLIF (open-TLIF). Short and long-term outcomes, fusion rate, and cost-effectiveness ... | 10.1177/2192568219882344 | 32,528,799 | Global spine journal | 2,020 | ||
Parallel processing relies on a distributed, low-dimensional cortico-cerebellar architecture. | A characteristic feature of human cognition is our ability to 'multi-task'-performing two or more tasks in parallel-particularly when one task is well learned. How the brain supports this capacity remains poorly understood. Most past studies have focussed on identifying the areas of the brain-typically the dorsolateral... | 10.1162/netn_a_00308 | 37,397,895 | Network neuroscience (Cambridge, Mass.) | 2,023 | ||
Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions. | The comprehensive inventory of functional elements in 44 human genomic regions carried out by the ENCODE Project Consortium enables for the first time a global analysis of the genomic distribution of transcriptional regulatory elements. In this study we developed an intuitive and yet powerful approach to analyze the di... | 10.1101/gr.5573107 | 17,567,997 | D002877:Chromosomes, Human; D030541:Databases, Genetic; D015894:Genome, Human; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D050436:Regulatory Elements, Transcriptional; D017422:Sequence Analysis, DNA; D014158:Transcription, Genetic | Genome research | 2,007 | |
Structural basis for CDK7 activation by MAT1 and Cyclin H. | Cyclin-dependent kinase 7 (CDK7), Cyclin H, and the RING-finger protein MAT1 form the heterotrimeric CDK-activating kinase (CAK) complex which is vital for transcription and cell-cycle control. When associated with the general transcription factor II H (TFIIH) it activates RNA polymerase II by hyperphosphorylation of i... | 10.1073/pnas.2010885117 | 33,055,219 | D002453:Cell Cycle; D002597:Chaetomium; D056748:Cyclin H; D018844:Cyclin-Dependent Kinases; D005656:Fungal Proteins; D010766:Phosphorylation; D014158:Transcription, Genetic; D000095043:Cyclin-Dependent Kinase-Activating Kinase | Proceedings of the National Academy of Sciences of the United States of America | 2,020 | D056748:Cyclin H; D005656:Fungal Proteins; D018844:Cyclin-Dependent Kinases; D000095043:Cyclin-Dependent Kinase-Activating Kinase |
Pluronic Induced Interparticle Attraction and Re-entrant Liquid-Liquid Phase Separation in Charged Silica Nanoparticle Suspensions. | Tuning surface properties of nanoparticles by introducing charge, surface functionalization, or polymer grafting is central to their stability and applications. Here, we show that introducing non-DLVO forces like steric and hydrophobic effects in charged silica nanoparticle suspensions through interaction with a nonion... | 10.1021/acs.langmuir.3c00491 | 37,269,303 | Langmuir : the ACS journal of surfaces and colloids | 2,023 | ||
Strontium-89 radionuclide therapy: a dosimetric study using impulse response function analysis. | In a series of patients receiving 89Sr palliation for metastasised prostatic carcinoma, strontium renal plasma clearance was found to vary from 0.14 to 11.81 day-1, and the extent of skeletal metastatic disease seen on 99Tcm-MDP images varied from a few small metastases to a superscan. Using a numerical technique based... | 10.1259/0007-1285-60-715-685 | 3,620,827 | D001853:Bone Marrow; D001859:Bone Neoplasms; D006801:Humans; D007700:Kinetics; D008297:Male; D011471:Prostatic Neoplasms; D011879:Radiotherapy Dosage; D013326:Strontium Radioisotopes; D013997:Time Factors | The British journal of radiology | 1,987 | D013326:Strontium Radioisotopes |
The evolution of chronic infection strategies in the alpha-proteobacteria. | Many of the alpha-proteobacteria establish long-term, often chronic, interactions with higher eukaryotes. These interactions range from pericellular colonization through facultative intracellular multiplication to obligate intracellular lifestyles. A common feature in this wide range of interactions is modulation of ho... | 10.1038/nrmicro1044 | 15,550,939 | D020561:Alphaproteobacteria; D000818:Animals; D005075:Biological Evolution; D002908:Chronic Disease; D005057:Eukaryotic Cells; D016680:Genome, Bacterial; D016905:Gram-Negative Bacterial Infections; D006801:Humans; D010944:Plants; D013559:Symbiosis; D014774:Virulence | Nature reviews. Microbiology | 2,004 | |
[Clinical manifestations of gout]. | Gout is a chronic disease, clearly progressing in incidence and prevalence, which threaten to pose a real problem of public health in the near future. Gout is to be understood for as the progression in a continuum of a single and same disease: hyperuricemia. This awareness allows to better apprehend the disease's evolu... | 17,458,150 | D006073:Gout; D006801:Humans; D033461:Hyperuricemia | Revue medicale suisse | 2,007 | ||
Assessing advance directives in the homebound elderly. | We studied the prevalence of specific barriers that prevent indigent homebound older adults from obtaining advance directives and tested the effectiveness of clinical reminders for lowering the number of clients without advance directives. Case managers interviewed 1569 clients to determine whether they had an advance ... | 10.1177/1049909108324359 | 18,843,136 | D016223:Advance Directives; D000368:Aged; D000369:Aged, 80 and over; D001293:Attitude to Death; D002755:Choice Behavior; D003657:Decision Making; D005260:Female; D018577:Homebound Persons; D006801:Humans; D008297:Male; D016743:Mental Competency; D008875:Middle Aged; D010353:Patient Education as Topic; D028701:Patient R... | The American journal of hospice & palliative care | 2,009 | |
Global Trends in Knowledge, Attitude, and Awareness of Orthodontists Regarding the Management of Patients with Cleft lip and/or Palate: A Systematic Review. | The aim of the present systematic review was to assess the trends in knowledge, attitude, awareness, and practice among orthodontists regarding the management of patients with cleft lip and/or palate.
An a priori protocol was developed as per the best practices of evidence-based medicine and registered in Prospero (... | 10.1177/10556656221108856 | 35,711,158 | D006801:Humans; D002971:Cleft Lip; D002972:Cleft Palate; D000066792:Orthodontists; D007722:Health Knowledge, Attitudes, Practice | The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association | 2,023 | |
Ketone bodies in epilepsy. | Seizures that are resistant to standard medications remain a major clinical problem. One underutilized option for patients with medication-resistant seizures is the high-fat, low-carbohydrate ketogenic diet. The diet received its name based on the observation that patients consuming this diet produce ketone bodies (e.g... | 10.1111/j.1471-4159.2012.07670.x | 22,268,909 | D000818:Animals; D000927:Anticonvulsants; D002952:Citric Acid Cycle; D055423:Diet, Ketogenic; D004734:Energy Metabolism; D004827:Epilepsy; D006801:Humans; D007657:Ketone Bodies | Journal of neurochemistry | 2,012 | D000927:Anticonvulsants; D007657:Ketone Bodies |
Diazoxide preconditioning alleviates caspase-dependent and caspase-independent apoptosis induced by anoxia-reoxygenation of PC12 cells. | Although there is increasing evidence that the ATP sensitive potassium channel (K(ATP)) opener exhibits neuroprotective effects against ischaemic neural damage, little is known about the mechanism. Mitochondria play a key role in apoptosis by releasing many important factors, including cytochrome c and apoptosis-induci... | 10.1093/jb/mvq074 | 20,616,381 | D000818:Animals; D017209:Apoptosis; D020169:Caspases; D002470:Cell Survival; D003981:Diazoxide; D005947:Glucose; D000860:Hypoxia; D008928:Mitochondria; D010100:Oxygen; D016716:PC12 Cells; D015221:Potassium Channels; D051381:Rats; D014665:Vasodilator Agents | Journal of biochemistry | 2,010 | D015221:Potassium Channels; D014665:Vasodilator Agents; C117780:mitochondrial K(ATP) channel; D020169:Caspases; D005947:Glucose; D003981:Diazoxide; D010100:Oxygen |
An Instrumented Workstation to Evaluate Weight-Bearing Distribution in the Sitting Posture. | BACKGROUND
Sitting posture may be related to risk factors, including inadequate weight-bearing support, particularly when maintained for long periods. Considering that body weight is loaded in a closed support system composed of the seat, backrest, floor and working surface, the aims of the present study were to descri... | 10.1016/j.shaw.2019.01.006 | 31,497,327 | Safety and health at work | 2,019 | ||
Secondary polycythaemia. | The secondary polycythaemias are classified on an aetio-pathological basis and the main pathological and clinical features of the individual types are presented in the light of data in the literature and own observations in 138 cases seen during 15 years. The general lines and possibilities of therapy are discussed. | 617,924 | D000328:Adult; D001803:Blood Transfusion; D003911:Dextrans; D006801:Humans; D000860:Hypoxia; D007501:Iron; D008297:Male; D010100:Oxygen; D011086:Polycythemia | Acta medica Academiae Scientiarum Hungaricae | 1,977 | D003911:Dextrans; D007501:Iron; D010100:Oxygen | |
A new robust model of one-class classification by interval-valued training data using the triangular kernel. | A robust one-class classification model as an extension of Campbell and Bennett's (C-B) novelty detection model on the case of interval-valued training data is proposed in the paper. It is shown that the dual optimization problem to a linear program in the C-B model has a nice property allowing to represent it as a set... | 26,093,040 | D000465:Algorithms; D001185:Artificial Intelligence; D016014:Linear Models; D008962:Models, Theoretical; D016011:Normal Distribution; D060388:Support Vector Machine | Neural networks : the official journal of the International Neural Network Society | 2,015 | ||
Efficacy of membrane filtration, influence on hemostasis, immunoglobulins and inflammation mediators during daily plasma exchanges. | Plasma exchange (PE) by membrane filtration was performed with the following hollow fibers: cellulose-diacetate (Plasmaflo 01, Plasmaflo 02, Asahi, Japan), polypropylene (Plasmaflux, Fresenius, FRG) and polymethylmethacrylate (Plasmax, Toray, Japan). The elimination-coefficient (EC) for certain plasma proteins was calc... | 6,642,746 | D005374:Filtration; D006487:Hemostasis; D006801:Humans; D007136:Immunoglobulins; D007249:Inflammation; D008567:Membranes, Artificial; D010951:Plasma Exchange; D013997:Time Factors | The International journal of artificial organs | 1,983 | D007136:Immunoglobulins; D008567:Membranes, Artificial | |
Trial of a novel prostacyclin analog, UT-15, in patients with severe intermittent claudication. | Prostacyclin is an endothelially derived vasodilator and inhibitor of platelet aggregation. Despite its therapeutic potential for peripheral arterial disease, the short half-life and chemical instability are barriers to routine therapy. Accordingly, prostacyclin analogs are being evaluated in patients with peripheral a... | 11,213,235 | D000368:Aged; D001775:Blood Circulation; D001783:Blood Flow Velocity; D011464:Epoprostenol; D005260:Female; D005263:Femoral Artery; D006439:Hemodynamics; D006801:Humans; D007275:Injections, Intravenous; D007383:Intermittent Claudication; D007866:Leg; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery; D016909:... | Vascular medicine (London, England) | 2,000 | D014665:Vasodilator Agents; D011464:Epoprostenol; C427248:treprostinil | |
Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer. | Patched1 heterozygous mice (Ptch1(+/-)) are useful for basal cell carcinoma (BCC) studies, being remarkably susceptible to BCC induction by ultraviolet or ionizing radiation. Analogously, skin carcinogenesis-susceptible (Car-S) mice are elective for studies of papilloma and squamous cell carcinoma (SCC) induction. We p... | 10.1093/carcin/bgn243 | 18,952,596 | D000818:Animals; D002280:Carcinoma, Basal Cell; D002294:Carcinoma, Squamous Cell; D002471:Cell Transformation, Neoplastic; D019938:Cyclin D1; D004195:Disease Models, Animal; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D005260:Female; D008297:Male; D051379:Mice; D009381:Neoplasms,... | Carcinogenesis | 2,009 | D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; C000606240:Ptch1 protein, mouse; D011956:Receptors, Cell Surface; D019938:Cyclin D1 |
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. | Mitochondria-directed antioxidants 2-5 were designed by conjugating curcumin congeners with different polyamine motifs as vehicle tools. The conjugates emerged as efficient antioxidants in mitochondria and fibroblasts and also exerted a protecting role through heme oxygenase-1 activation. Notably, the insertion of a po... | 10.1021/jm100637k | 20,831,222 | D000818:Animals; D000970:Antineoplastic Agents; D000975:Antioxidants; D002417:Cattle; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D003474:Curcumin; D004354:Drug Screening Assays, Antitumor; D042783:Endothelial Cells; D004730:Endothelium, Vascular; D004789:Enzyme Activation; D005347:Fibrobla... | Journal of medicinal chemistry | 2,010 | D000970:Antineoplastic Agents; D000975:Antioxidants; D018696:Neuroprotective Agents; D011073:Polyamines; D017382:Reactive Oxygen Species; D051547:Heme Oxygenase-1; D003474:Curcumin |
Efficient upconversion luminescence from Ba5Gd8Zn4O21:Yb(3+), Er(3+) based on a demonstrated cross-relaxation process. | Under 971 nm excitation, bright green and red emissions from Yb(3+)/Er(3+) co-doped Ba5Gd8Zn4O21 phosphor can be observed, especially the intense red emission in highly doped samples. The experimental results indicate that Ba5Gd8Zn4O21:Yb(3+), Er(3+) emits stronger upconversion luminescence than NaYF4:Yb(3+), Er(3+) un... | 10.1038/srep22545 | 26,931,554 | Scientific reports | 2,016 | ||
CSF GABA is reduced in first-episode psychosis and associates to symptom severity. | Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains of mental function. γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain and is increasingly recognized to have a significant role in the pathophysiology of the disorder. In the present study, cere... | 10.1038/mp.2017.25 | 28,289,277 | D000328:Adult; D014150:Antipsychotic Agents; D001921:Brain; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders; D012559:Schizophrenia; D055815:Young Adult; D005680:gamma-Aminobutyric Acid | Molecular psychiatry | 2,018 | D014150:Antipsychotic Agents; D005680:gamma-Aminobutyric Acid |
Plant defensin AhPDF1.1 is not secreted in leaves but it accumulates in intracellular compartments. | • Apart from their antifungal role, plant defensins have recently been shown to be involved in abiotic stress tolerance or in inhibition of root growth when added in plant culture medium. We studied the subcellular localization of these proteins, which may account for these different roles. • Stable and transient expre... | 10.1111/j.1469-8137.2011.03792.x | 21,679,189 | D000222:Adaptation, Physiological; D000595:Amino Acid Sequence; D017360:Arabidopsis; D029681:Arabidopsis Proteins; D002451:Cell Compartmentation; D002473:Cell Wall; D048271:Chitosan; D023082:Defensins; D049452:Green Fluorescent Proteins; D007118:Immunoassay; D042541:Intracellular Space; D008969:Molecular Sequence Data;... | The New phytologist | 2,011 | D029681:Arabidopsis Proteins; D023082:Defensins; D021382:Protein Sorting Signals; D011993:Recombinant Fusion Proteins; D049452:Green Fluorescent Proteins; D048271:Chitosan; D015032:Zinc |
A family of finite-temperature electronic phase transitions in graphene multilayers. | Suspended Bernal-stacked graphene multilayers up to an unexpectedly large thickness exhibit a broken-symmetry ground state whose origin remains to be understood. We show that a finite-temperature second-order phase transition occurs in multilayers whose critical temperature (T c) increases from 12 kelvins (K) in bilaye... | 10.1126/science.aar6855 | 30,337,406 | Science (New York, N.Y.) | 2,018 | ||
Evaluation of blood pressure profile in chronic hemodialysis patients using two measurement methods: Home blood pressure measurement and conventional measurement. | The monitoring of hypertension (HTN) in dialysis is often delicate with potentially false measurements due to the white coat effect on the one hand and masked HTN (M-HTN) on the other hand. In this population, there is much controversy over the ideal moment for taking blood pressure (BP) and the target values. An answe... | 10.4103/1319-2442.270258 | 31,696,841 | D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D059468:Masked Hypertension; D008875:Middle Aged; D009819:Office Visits; D011237:Predictive Value of Tests; D015995:Prevalence; D006435:Renal Dialysis; D05... | Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia | 2,019 | |
Synthesis of the Unknown Indeno[1,2-a]fluorene Regioisomer: Crystallographic Characterization of Its Dianion. | Of the five possible indenofluorene regioisomers, examples of a fully conjugated indeno[1,2-a]fluorene scaffold have so far remained elusive. This work reports the preparation and characterization of 7,12-dimesitylindeno[1,2-a]fluorene as a highly reactive species. Experimental and computational data support the notion... | 10.1002/anie.201709282 | 28,985,444 | Angewandte Chemie (International ed. in English) | 2,017 | ||
Prevalence of Anal Human Papillomavirus Vaccine Types in the Bangkok Men Who Have Sex With Men Cohort Study. | BACKGROUND
The quadrivalent human papillomavirus (qHPV) and 9 valent (nHPV) vaccine are licensed for males to prevent anal HPV-associated dysplasia and cancer caused by HPV types 6, 11, 16, and 18 (qHPV) and additional types 33, 35, 45, 52, and 58 (nHPV), respectively. Both conditions are common in HIV-infected and HIV... | 10.1097/OLQ.0000000000000372 | 26,562,695 | D000328:Adult; D001003:Anal Canal; D001005:Anus Neoplasms; D015496:CD4-Positive T-Lymphocytes; D015331:Cohort Studies; D060085:Coinfection; D004279:DNA, Viral; D006679:HIV Seropositivity; D006291:Health Policy; D018451:Homosexuality, Male; D052163:Human papillomavirus 6; D006801:Humans; D017589:Immunization Programs; D... | Sexually transmitted diseases | 2,015 | D004279:DNA, Viral; D053918:Papillomavirus Vaccines |
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