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Taking up the challenge of measuring prolonged pain in (premature) neonates: the COMFORTneo scale seems promising. | OBJECTIVES
Pain assessment is essential to tailor intensive care of neonates. The present focus is on acute procedural pain; assessment of pain of longer duration remains a challenge. We therefore tested a modified version of the COMFORT-behavior scale-named COMFORTneo-for its psychometric qualities in the Neonatal Int... | 10.1097/AJP.0b013e3181a5b52a | 19,692,803 | D000700:Analgesics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009730:Nursing Assessment; D019370:Observation; D010146:Pain; D010147:Pain Measurement; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D... | The Clinical journal of pain | 2,009 | D000700:Analgesics |
Translating exercise intentions into behavior: personality and social cognitive correlates. | The purpose of this study was to detail the variability found in the exercise intention-behavior relationship and investigate social cognitive and personality correlates of successful intention translation. Participants were 300 undergraduate students who completed measures of exercise social cognition (theory of plann... | 10.1177/13591053030084004 | 19,127,711 | D000328:Adult; D003071:Cognition; D015444:Exercise; D006801:Humans; D033182:Intention; D010551:Personality; D012919:Social Behavior; D012938:Social Perception | Journal of health psychology | 2,003 | |
Anti-nuclear antibody testing in children: How much is really necessary? | BACKGROUND
Anti-nuclear antibody (ANA) testing is most commonly ordered by general pediatricians to evaluate children with musculoskeletal system complaints. Given the limited utility of the test, we aimed to estimate the effectiveness of ordering ANA testing in childhood.
METHODS
Children referred to our department ... | 10.1111/ped.14592 | 33,411,356 | D000293:Adolescent; D000974:Antibodies, Antinuclear; D001327:Autoimmune Diseases; D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic; D012189:Retrospective Studies; D012216:Rheumatic Diseases | Pediatrics international : official journal of the Japan Pediatric Society | 2,021 | D000974:Antibodies, Antinuclear |
Clinical course of idiopathic pneumonia after bone marrow transplantation. | We describe the clinical course of idiopathic pneumonia diagnosed by lung biopsy after allogeneic marrow transplantation and the associations of clinical presentation with outcome. All allogeneic marrow transplant recipients with an open-lung biopsy at a single marrow transplantation research center between January 198... | 10.1164/ajrccm/147.6_Pt_1.1393 | 8,503,550 | D000293:Adolescent; D000328:Adult; D001706:Biopsy; D016026:Bone Marrow Transplantation; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008168:Lung; D008297:Male; D008875:Middle Aged; D01101... | The American review of respiratory disease | 1,993 | |
General health screenings to improve cardiovascular risk profiles: a randomized controlled trial in general practice with 5-year follow-up. | OBJECTIVES
To investigate the impact of general health screenings and discussions with general practitioners on the cardiovascular risk profile of a random population of patients.
STUDY DESIGN
A population-based, randomized, controlled, 5-year follow-up trial conducted in a primary care setting.
POPULATION
The stud... | 12,100,779 | D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases; D005194:Family Practice; D005260:Female; D006293:Health Promotion; D006304:Health Status; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015995:Prevalence; D011314:Preventive Health Services; D012307:Risk Factors; D012... | The Journal of family practice | 2,002 | ||
The load supported by small floating objects. | We consider the equilibrium flotation of a two-dimensional cylinder and a sphere at an interface between two fluids. We give conditions on the density and radius of these objects for them to be able to float at the interface and discuss the role played by the contact angle in determining these conditions. For cylinders... | 10.1021/la060606m | 16,800,646 | Langmuir : the ACS journal of surfaces and colloids | 2,006 | ||
Ground states of the lattice-gas model on the triangular lattice with nearest- and next-nearest-neighbor pairwise interactions and with three-particle interaction: ground states at boundaries of full-dimensional regions. | We analyze the ground states at boundaries of four-dimensional (full-dimensional) ground-state regions of the lattice-gas model on the infinite plane triangular lattice with nearest- and next-nearest-neighbor pairwise interactions and with additional interaction between three particles at the vertices of a nearest-neig... | 10.1103/PhysRevE.84.061102 | 22,304,035 | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,011 | ||
Dental Age Estimation Helps Create a New Identity. | Age estimation involves the reconstruction of age by biological parameters such as skeletal and dental development in minors, or reduction of pulp chamber in adults, to gain indications concerning the chronological age of the person. In most cases, it is needed in forensic scenarios to verify if the supposed age of an ... | 10.1097/PAF.0000000000000178 | 26,079,404 | D000328:Adult; D000366:Age Determination by Teeth; D000647:Amnesia; D003782:Dental Pulp; D006801:Humans; D008297:Male; D011862:Radiography, Panoramic | The American journal of forensic medicine and pathology | 2,015 | |
Psychometric evaluation of the DMSS-4 in a cohort of elderly post-operative hip fracture patients with delirium. | BACKGROUND
Delirium is a common neuropsychiatric syndrome with considerable heterogeneity in clinical profile. Rapid reliable identification of clinical subtypes can allow for more targeted research efforts.
METHODS
We explored the concordance in attribution of motor subtypes between the Delirium Motor Subtyping Scal... | 10.1017/S1041610216000065 | 26,847,532 | D000368:Aged; D000369:Aged, 80 and over; D002492:Central Nervous System Depressants; D003071:Cognition; D003693:Delirium; D004311:Double-Blind Method; D005260:Female; D005592:Fracture Fixation; D015577:Geriatric Assessment; D006620:Hip Fractures; D006801:Humans; D008297:Male; D008550:Melatonin; D009426:Netherlands; D01... | International psychogeriatrics | 2,016 | D002492:Central Nervous System Depressants; D008550:Melatonin |
Tuning nanoscopic water layers on hydrophobic and hydrophilic surfaces with laser light. | The evolutional function of ordered interfacial water near solid surfaces was postulated by Szent-Györgyi: "Life actually, may have started with building these water structures." Here we report their tunability with laser light on both hydrophobic and hydrophilic surfaces. On the former, the light caused their depletio... | 10.1021/la7032737 | 18,171,094 | Langmuir : the ACS journal of surfaces and colloids | 2,008 | ||
New Oxidovanadium(IV) Coordination Complex Containing 2-Methylnitrilotriacetate Ligands Induces Cell Cycle Arrest and Autophagy in Human Pancreatic Ductal Adenocarcinoma Cell Lines. | Pancreatic cancer is characterized by one of the lowest five-year survival rates. In search for new treatments, some studies explored several metal complexes as potential anticancer drugs. Therefore, we investigated three newly synthesized oxidovanadium(IV) complexes with 2-methylnitrilotriacetate (bcma3-), N-(2-carbam... | 10.3390/ijms20020261 | 30,634,697 | D000970:Antineoplastic Agents; D017209:Apoptosis; D001343:Autophagy; D014408:Biomarkers, Tumor; D021441:Carcinoma, Pancreatic Ductal; D059447:Cell Cycle Checkpoints; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D015394:Molecular Structure; D010190:Pancreatic Neoplasms; D017382:Reactive Oxygen S... | International journal of molecular sciences | 2,019 | D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D017382:Reactive Oxygen Species; D017968:Vanadium Compounds |
Temporal lobe epilepsy and emotion recognition without amygdala: a case study of Urbach-Wiethe disease and review of the literature. | We describe the epilepsy features and emotion recognition abilities (recognition of basic facial emotions and recognition of emotional prosody) in a patient with Urbach-Wiethe disease with bilateral amygdala calcifications. Our data, supported by ictal video-EEG recording, indicated that our patient suffered from mesia... | 10.1684/epd.2014.0696 | 25,465,029 | D000328:Adult; D000679:Amygdala; D004644:Emotions; D004833:Epilepsy, Temporal Lobe; D005149:Facial Expression; D005260:Female; D006801:Humans; D008065:Lipoid Proteinosis of Urbach and Wiethe | Epileptic disorders : international epilepsy journal with videotape | 2,014 | |
NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven. | Illudins S and M are extremely cytotoxic products of the fungus Omphalotus illudens. They were evaluated as possible anticancer chemotherapeutic agents but displayed unfavorable therapeutic indices. Irofulven (6-hydroxymethylacylfulvene), a less toxic, synthetic derivative of illudin S, has proven very effective in man... | 10.1158/1078-0432.ccr-03-0162 | 14,977,853 | D000429:Alcohol Oxidoreductases; D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D002460:Cell Line; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005978:Glutathione; D006801:Humans; D007659:Ketones; D0077... | Clinical cancer research : an official journal of the American Association for Cancer Research | 2,004 | D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D007659:Ketones; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C052673:illudin M; C102714:irofulven; D000429:Alcohol Oxidoreductases; C082646:leukotriene B4 12-hydroxydehydrogenase; C008105:illudin S; D005978:... |
Permanent pacemaker implantation in a challenging anatomy: Persistent left superior vena cava. | The persistence of the left superior vena cava is one of the most common abnormalities that could affect the thoracic venous return, despite its rare occurrence. It can usually be found as the only or in combination with other congenital cardiac abnormalities. Even though it is usually asymptomatic and it rarely has im... | 10.22551/2020.27.0702.10170 | 34,754,925 | Archive of clinical cases | 2,020 | ||
CuH-Catalyzed Enantioselective Desymmetrization of Cyclic 1,3-Diketones. | Herein, we report a CuH-catalyzed asymmetric desymmetrization of prochiral cyclopentane-1,3-diones to access cyclic 3-hydroxy ketones having an all-carbon quaternary center with high diastereoselectivity via hydrosilylation using PMHS as an inexpensive hydride source. This reaction displays high functional group tolera... | 10.1021/acs.orglett.2c03359 | 36,326,444 | D013237:Stereoisomerism; D002384:Catalysis; D007659:Ketones; D000475:Alkenes; D007211:Indoles | Organic letters | 2,022 | D007659:Ketones; D000475:Alkenes; D007211:Indoles |
IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas. | OBJECTIVES
Interferon regulatory factor 8 (IRF8) is a new biomarker shown to be positive in monocytic leukemias as well as in B cells. As a transcription factor, it plays a critical role in pre-B-cell differentiation and induction of tolerance pathways, among other functions. Given the frequent diagnostic dilemma in CD... | 10.1093/ajcp/aqac044 | 35,460,405 | D003937:Diagnosis, Differential; D006689:Hodgkin Disease; D006801:Humans; D050835:Interferon Regulatory Factors; D017730:Ki-1 Antigen; D017728:Lymphoma, Large-Cell, Anaplastic; D020794:Receptor Protein-Tyrosine Kinases; D012189:Retrospective Studies | American journal of clinical pathology | 2,022 | D050835:Interferon Regulatory Factors; D017730:Ki-1 Antigen; C064179:interferon regulatory factor-8; D020794:Receptor Protein-Tyrosine Kinases |
Factors Related to the Level of Depression and Suicidal Behavior Among Men With Diagnosed Depression, Physically Ill Men, and Healthy Men. | Depression is the most common psychiatric disorder in people who die by suicide. Awareness of risk factors for suicide in depression is important for clinicians. The study was aimed at establishing models of factors related to the level of depression and suicidal behavior among men from three different groups-in men wi... | 10.3389/fpsyt.2021.644097 | 34,248,697 | Frontiers in psychiatry | 2,021 | ||
The antiphospholipid antibodies. | Antiphospholipid antibodies (APLAs) are a group of autoantibodies directed against certain phospholipids, or their protein cofactors. Assay of APLAs is important because their interaction with anionic phospholipid-protein cofactors can generate a syndrome of hypercoagulability associated with a wide variety of thromboe... | 10.1163/15685590160141314 | 12,038,512 | D000818:Animals; D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I | Haematologia | 2,002 | D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I |
[Development and study of spring bread wheat variety Pamyati Maystrenko with introgression of genetic material from synthetic hexaploid Triticum timopheevii zhuk. x Aegilops tauschii Coss]. | Synthetic hexaploids are bridges for transferring new genes that determine resistance to stress factors from wild-type species to bread wheat. In the present work, the method of developing the spring bread wheat variety Pamyati Maystrenko and the results of its study are described. This variety was obtained using one o... | 10.7868/s0016675813010062 | 23,662,428 | D002678:Chimera; D032461:Chromosomes, Plant; D003433:Crosses, Genetic; D060467:Disease Resistance; D011003:Ploidies; D012641:Selection, Genetic; D014908:Triticum | Genetika | 2,013 | |
Clinical effectiveness of short course oral prednisone for stricture prevention after semi-circumferential esophageal endoscopic submucosal dissection. | Background and study aims Esophageal strictures (ES) occur frequently after semi-circumferential endoscopic submucosal dissection (ESD) for the eradication of superficial esophageal neoplasms and negatively impact a patient's quality of life. Oral corticosteroids have been shown to be clinically effective, but the mos... | 10.1055/a-1789-0266 | 35,692,934 | Endoscopy international open | 2,022 | ||
A randomized controlled trial targeting alcohol use and sexual assault risk among college women at high risk for victimization. | Sexual assault risk reduction programs do not target alcohol use despite the widespread knowledge that alcohol use is a risk factor for being victimized. The current study assessed the effectiveness of a web-based combined sexual assault risk and alcohol use reduction program using a randomized control trial. A total o... | 26,408,290 | D000293:Adolescent; D000428:Alcohol Drinking; D000067292:Alcohol Drinking in College; D000438:Alcohols; D019548:Crime Victims; D005260:Female; D006801:Humans; D011902:Rape; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012742:Sex Offenses; D013334:Students; D011795:Surveys and Questionnaires; D014495:Universi... | Behaviour research and therapy | 2,015 | D000438:Alcohols | |
The polypyrimidine tract binding (PTB) protein interacts with single-stranded DNA in a sequence-specific manner. | Polypyrimidine tract binding (PTB) protein is a cellular factor whose function is unknown. Various RNA or single-stranded DNA sequences have been shown to interact with PTB. In this paper, using laser UV crosslinking and electrophoretic mobility shift assays to probe DNA-protein interactions, we demonstrate that PTB bi... | 10.1093/nar/24.9.1608 | 8,649,976 | D000256:Adenoviridae; D001483:Base Sequence; D001667:Binding, Competitive; D003432:Cross-Linking Reagents; D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D004926:Escherichia coli; D007700:Kinetics; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009838:Oligodeoxyribonucleotides; D010957:Plasmid... | Nucleic acids research | 1,996 | D003432:Cross-Linking Reagents; D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D009838:Oligodeoxyribonucleotides; D016601:RNA-Binding Proteins; D011993:Recombinant Fusion Proteins; D038941:Polypyrimidine Tract-Binding Protein |
Spinal cord involvement in two children with posterior reversible encephalopathy syndrome. | Spinal cord involvement (SCI) is a rare feature of posterior reversible encephalopathy syndrome (PRES), especially in children. SCI is generally symptomatic, and may have a different outcome compared with encephalic localization of PRES. We reported about two cases of SCI in pediatric patients with PRES, after multimod... | 10.2217/cns-2017-0003 | 28,984,140 | D000293:Adolescent; D002528:Cerebellar Neoplasms; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008527:Medulloblastoma; D054038:Posterior Leukoencephalopathy Syndrome; D013116:Spinal Cord | CNS oncology | 2,017 | |
A method for experimental characterization of the noise performance of elastographic systems. | Characterization of the noise performance of the elastographic system is necessary to evaluate the accuracy and precision of the estimated strain. The elastographic system includes the ultrasonic scanner, the computer controlled compression device and the strain estimation algorithm. In this paper, we present a method ... | 10.1177/016173469902100102 | 10,230,007 | D004548:Elasticity; D005780:Gelatin; D007091:Image Processing, Computer-Assisted; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D014463:Ultrasonography | Ultrasonic imaging | 1,999 | D005780:Gelatin |
Replication of the gonad-specific virus Hz-2V in Ld652Y cells mimics replication in vivo. | A newly discovered, nonoccluded insect virus, known as gonad-specific virus or Hz-2V, was found to replicate differently in two insect cell lines derived from ovarian tissues (Tn-368 cells from Trichoplusia ni and Ld652Y from Lymantria dispar). Differences between these two cell lines were observed in virus plaque form... | 10.1006/jipa.2000.4990 | 11,161,993 | D000818:Animals; D016367:Baculoviridae; D002460:Cell Line; D004261:DNA Replication; D007915:Lepidoptera; D018716:Molecular Mimicry; D013997:Time Factors; D014776:Virus Cultivation; D014779:Virus Replication | Journal of invertebrate pathology | 2,001 | |
Patterns of muscular strain in the embryonic heart wall. | The hypothesis that inner layers of contracting muscular tubes undergo greater strain than concentric outer layers was tested by numerical modeling and by confocal microscopy of strain within the wall of the early chick heart. We modeled the looped heart as a thin muscular shell surrounding an inner layer of sponge-lik... | 10.1002/dvdy.21958 | 19,418,446 | D000818:Animals; D002642:Chick Embryo; D004452:Echocardiography; D006321:Heart; D006352:Heart Ventricles; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D012518:Sarcomeres; D013314:Stress, Mechanical | Developmental dynamics : an official publication of the American Association of Anatomists | 2,009 | |
Intracellular Conditions Required for Initiation of Solvent Production by Clostridium acetobutylicum. | We investigated the intracellular physiological conditions associated with the induction of butanol-producing enzymes in Clostridium acetobutylicum. During the acidogenic phase of growth, the internal pH decreased in parallel with the decrease in the external pH, but the internal pH did not go below 5.5 throughout batc... | 10.1128/aem.52.1.86-91.1986 | 16,347,119 | Applied and environmental microbiology | 1,986 | ||
Microcystic adnexal carcinoma of the skin. A reappraisal of the differentiation and differential diagnosis of an underrecognized neoplasm. | BACKGROUND
Microcystic adnexal carcinoma (MAC) is a locally aggressive adnexal neoplasm whose histogenesis is disputed. Many cases referred to us had been misdiagnosed.
OBJECTIVE
Our purpose was to clarify the differential diagnosis and differentiation of MAC.
METHODS
We sought follow-up data and examined routinely... | 10.1016/0190-9622(93)70228-l | 7,691,906 | D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018952:Antigens, CD34; D000951:Antigens, Neoplasm; D018280:Carcinoma, Skin Appendage; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D... | Journal of the American Academy of Dermatology | 1,993 | D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018952:Antigens, CD34; D000951:Antigens, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53 |
[Properties of the new D3-like Pseudomonas aeruginosa bacteriophage phiPMG1: genome structure and prospects for the use in phage therapy]. | Results of studying the novel virulent phage phiPMG1 active on Pseudomonas aeruginosa are presented. phiPMG1 was shown to exhibit detectable homology and resemblance in the total genome structure with temperate converting phage D3. Phage phiPMG1 differs from D3 in that it fails to stably lysogenize bacteria and can gro... | 23,113,333 | D022761:Gene Transfer, Horizontal; D005814:Genes, Viral; D016679:Genome, Viral; D017105:Pseudomonas Phages; D011550:Pseudomonas aeruginosa; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid | Genetika | 2,012 | ||
Digoxin-like immunoreactive substances in chronic liver disease. | Digoxin-like immunoreactive substances, which cross-react with digoxin antibody, have been found to have natriuretic effect and Na+,K+-ATPase inhibitory effect. The role of digoxin-like immunoreactive substances in chronic liver disease was studied by radioimmunoassay in 63 serum and 60 urine samples from 58 patients w... | 10.1002/hep.1840090304 | 2,920,992 | D002908:Chronic Disease; D003404:Creatinine; D004077:Digoxin; D006801:Humans; D008107:Liver Diseases; D011863:Radioimmunoassay; D012964:Sodium | Hepatology (Baltimore, Md.) | 1,989 | D004077:Digoxin; D012964:Sodium; D003404:Creatinine |
Staged intact canal wall tympanoplasty for treatment of middle ear cholesteatoma. | Results of surgery for middle ear cholesteatoma were investigated in 202 ears of 197 patients who had undergone surgery by the staged intact canal wall technique. Surgical procedures used in the second stage for prevention of a retraction pocket were classified into three types: Type S1, no scutumplasty; Type S2, scutu... | 10.3950/jibiinkoka.101.236 | 9,545,770 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D018424:Cholesteatoma, Middle Ear; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016896:Treatment Outcome; D014433:Tympanoplasty | Nihon Jibiinkoka Gakkai kaiho | 1,998 | |
Computed tomography coronary angiography in asymptomatic patients. | PURPOSE
This study assessed the accuracy of computed tomography coronary angiography (CT-CA) for detecting significant coronary artery disease (CAD; ≥50% lumen reduction) in intermediate/high-risk asymptomatic patients.
MATERIALS AND METHODS
A total of 183 consecutive asymptomatic individuals (92 men; mean age 54±11 ... | 10.1007/s11547-011-0723-4 | 21,892,711 | D000328:Adult; D000368:Aged; D002114:Calcinosis; D017023:Coronary Angiography; D003324:Coronary Artery Disease; D023921:Coronary Stenosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011237:Predictive Value of Tests; D015995:Prevalence; D0185... | La Radiologia medica | 2,011 | |
Emergence of concurrent infections with colistin-resistant ESBL-positive Klebsiella pneumoniae and OXA-23-producing Acinetobacter baumannii sensitive to colistin only in a Romanian cardiac intensive care unit. | We report the emergence and analysis of a cluster of concurrent infections/colonisations with colistin-resistant Klebsiella pneumoniae and OXA-23 carbapenemase-producing Acinetobacter baumannii in patients who had undergone cardiac surgery. We describe the emergence of colistin-resistant K. pneumoniae harbouring blaCTX... | 10.1007/s10096-015-2453-3 | 26,239,064 | D000151:Acinetobacter Infections; D040981:Acinetobacter baumannii; D000900:Anti-Bacterial Agents; D016507:Cardiology Service, Hospital; D003091:Colistin; D003428:Cross Infection; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007710:Klebsiella Infections; D0... | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | 2,015 | D000900:Anti-Bacterial Agents; D003091:Colistin |
Novel technique for harvesting the sternoclavicular graft. | PURPOSE
Originally introduced for mandibular reconstruction more than 40 years ago, the sternoclavicular graft (SCG) has gained widespread popularity for the reconstruction of the ramus-condyle unit (RCU) owing to its anatomic and histological likeness to the normal mandibular condyle. Conventional longitudinal osteoto... | 10.1016/j.jcms.2016.11.009 | 27,939,038 | D000293:Adolescent; D000328:Adult; D000844:Ankylosis; D016025:Bone Transplantation; D002968:Clavicle; D005260:Female; D006801:Humans; D008297:Male; D063175:Mandibular Reconstruction; D011446:Prospective Studies; D013249:Sternum; D019224:Temporomandibular Joint Disc; D055815:Young Adult | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery | 2,017 | |
International Hand Function Study Following Distal Radial Access: The RATATOUILLE Study. | BACKGROUND
Distal radial access (DRA) has been proposed to improve procedure ergonomics and favor radial artery patency. Although promising data, nothing is known on evolving hand function after DRA.
OBJECTIVES
This study sought to comprehensively evaluate hand function in patients undergoing DRA.
METHODS
Real-worl... | 10.1016/j.jcin.2022.04.023 | 35,595,672 | D000368:Aged; D001157:Arterial Occlusive Diseases; D006225:Hand; D006470:Hemorrhage; D006801:Humans; D008297:Male; D008875:Middle Aged; D017534:Radial Artery; D016896:Treatment Outcome | JACC. Cardiovascular interventions | 2,022 | |
Metabolic disorders induced by psychotropic drugs. | Psychotropic drugs may be associated with metabolic disorders, often but not only triggered by weight gain. Disorders include dysglycemia and diabetes, atherogenic dyslipidemia and metabolic syndrome. Overall, metabolic risk is lower with antidepressants than with antipsychotics. Among antidepressants, metabolic disord... | 10.1016/j.ando.2023.03.006 | 36,963,753 | D006801:Humans; D003024:Clozapine; D000077152:Olanzapine; D011619:Psychotropic Drugs; D008659:Metabolic Diseases; D024821:Metabolic Syndrome | Annales d'endocrinologie | 2,023 | D003024:Clozapine; D000077152:Olanzapine; D011619:Psychotropic Drugs |
A case of biliary atresia with duplication of the common bile duct. | The authors report a case of biliary atresia (BA) with duplication of the common bile duct. A 1-month-old girl was referred for investigation of persistent jaundice. BA was suspected and confirmed with intraoperative cholangiography. A portoenterostomy was performed at 50 days of age. During dissection of the fibrous r... | 10.1053/jpsu.2001.21627 | 11,227,008 | D001656:Biliary Atresia; D003135:Common Bile Duct; D005260:Female; D006801:Humans; D007223:Infant; D011171:Portoenterostomy, Hepatic | Journal of pediatric surgery | 2,001 | |
Binocular video head impulse test: Normative data study. | Introduction
The video head impulse test (vHIT) evaluates the vestibulo-ocular reflex (VOR). It's usually recorded from only one eye. Newer vHIT devices allow a binocular quantification of the VOR.
Purpose Aim
To investigate the advantages of simultaneously recorded binocular vHIT (bvHIT) to detect the differences be... | 10.3389/fneur.2023.1153102 | 37,206,911 | Frontiers in neurology | 2,023 | ||
Concurrence of limb girdle muscular dystrophy and myasthenia gravis. | We describe a case of limb girdle muscular dystrophy with associated myasthenia gravis. This association has not been previously noted in the literature. The unusual feature of the case was that symptoms coexisted for several years before a correct diagnosis was made. The diagnosis was based on the clinical picture and... | 10.1001/archneur.1989.00520370103030 | 2,610,729 | D001706:Biopsy; D004576:Electromyography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles; D009136:Muscular Dystrophies; D009157:Myasthenia Gravis; D013997:Time Factors | Archives of neurology | 1,989 | |
Automated utility assessment of global health. | The objective of this study was to characterize the performance of an automated utility assessment instrument for measuring preferences for overall health. The study population consisted of 83 subjects recruited from the cafeteria of a large tertiary care hospital. We assessed utilities for current health relative to p... | 10.1007/BF00435983 | 8,901,381 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001294:Attitude to Health; D003661:Decision Support Techniques; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D008923:Missouri; D010865:Pilot Projects; D011788:Quality of Life; D018709:Statistics, Nonparametric | Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation | 1,996 | |
Characterization of the minimal DNA binding domain of the human papillomavirus e1 helicase: fluorescence anisotropy studies and characterization of a dimerization-defective mutant protein. | The E1 helicase of papillomaviruses is required for replication of the viral double-stranded DNA genome, in conjunction with cellular factors. DNA replication is initiated at the viral origin by the assembly of E1 monomers into oligomeric complexes that have unwinding activity. In vivo, this process is catalyzed by the... | 10.1128/jvi.77.9.5178-5191.2003 | 12,692,220 | D001483:Base Sequence; D004265:DNA Helicases; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D019281:Dimerization; D005454:Fluorescence Polarization; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D027383:Papillomaviridae; D014764:Viral Proteins | Journal of virology | 2,003 | D004279:DNA, Viral; D004268:DNA-Binding Proteins; C069814:E1 protein, Bovine papillomavirus; C084304:E1 protein, Human papillomavirus type 11; D014764:Viral Proteins; D004265:DNA Helicases |
Necessity of epicardial ablation for ventricular tachycardia after sequential endocardial approach. | BACKGROUND
Catheter ablation (CA) of ventricular tachycardia (VT) is an important treatment option in patients with structural heart disease (SHD) and implantable cardioverter defibrillator (ICD). A subset of patients requires epicardial CA for VT.
OBJECTIVE
The purpose of the study was to assess the significance of ... | 25,576,719 | D000368:Aged; D017115:Catheter Ablation; D004699:Endocardium; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System; D006339:Heart Rate; D006801:Humans; D008297:Male; D010496:Pericardium; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D017180:Tachycardia, Ventricular; D0168... | International journal of cardiology | 2,015 | ||
Functional Characterization of a Hydroxyacid/Alcohol Hydroxycinnamoyl Transferase Produced by the Liverwort Marchantia emarginata. | The aerial organs of most terrestrial plants are covered by a hydrophobic protective cuticle. The main constituent of the cuticle is the lipid polyester cutin, which is composed of aliphatic and aromatic domains. The aliphatic component is a polyester between fatty acid/alcohol and hydroxycinnamoyl acid. The BAHD/HxxxD... | 10.3390/molecules22111854 | 29,088,080 | D000214:Acyl Coenzyme A; D000217:Acyltransferases; D003593:Cytoplasm; D018506:Gene Expression Regulation, Plant; D006863:Hydrogen-Ion Concentration; D047008:Marchantia; D010802:Phylogeny; D010940:Plant Proteins; D030821:Plants, Genetically Modified; D011994:Recombinant Proteins; D013379:Substrate Specificity; D013696:T... | Molecules (Basel, Switzerland) | 2,017 | D000214:Acyl Coenzyme A; D010940:Plant Proteins; D011994:Recombinant Proteins; C119167:feruloyl-CoA; C058645:caffeoyl-coenzyme A; D000217:Acyltransferases |
Phase I study of the sequential administration of edatrexate and paclitaxel in patients with advanced solid tumors. | BACKGROUND
The antifolate edatrexate and the microtubule-stabilizing agent paclitaxel have both demonstrated single-agent activity in lung and breast cancer. In vitro, the sequential combination of edatrexate followed by paclitaxel produced synergistic antitumor effects. This trial was designed to find the maximum tole... | 10.1023/a:1026404812699 | 10,416,013 | D000328:Adult; D000368:Aged; D000630:Aminopterin; D000971:Antineoplastic Combined Chemotherapy Protocols; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D017239:Paclitaxel | Annals of oncology : official journal of the European Society for Medical Oncology | 1,999 | C040210:edatrexate; D000630:Aminopterin; D017239:Paclitaxel |
Lymphocytes binding C-reactive protein during acute rheumatic fever. | Lymphocytes binding C-reactive protein (CRP) were studied in 31 patients with acute rheumatic fever and 30 controls who were children. Marked elevations in both proportions and absolute numbers of CRP-binding lymphocytes were recorded in rheumatic fever (P less than 0.001). No clear correlation was noted between plasma... | 10.1172/JCI109056 | 659,600 | D000208:Acute Disease; D000293:Adolescent; D001665:Binding Sites; D002097:C-Reactive Protein; D002648:Child; D002675:Child, Preschool; D002819:Chorea; D005260:Female; D006331:Heart Diseases; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D008214:Lymphocytes; D008297:Male; D011485:Protein Binding; D011947:Receptor... | The Journal of clinical investigation | 1,978 | D007141:Immunoglobulin Fc Fragments; D011947:Receptors, Antigen, B-Cell; D002097:C-Reactive Protein |
[3H]phorbol ester binding sites and neuronal plasticity in the hippocampus following entorhinal cortex lesions. | Entorhinal cortex lesioning (ECL) produces a loss of more than 80% of the synapses in the outer molecular layer of the hippocampus. However, the loss of synapses is transient. Beginning a few days after denervation, new synapses are formed, virtually replacing the lost inputs within 2 months. Synaptic remodelling induc... | 10.1016/0006-8993(93)91485-b | 8,481,798 | D000110:Acetylcholinesterase; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D002540:Cerebral Cortex; D003714:Denervation; D005904:Glial Fibrillary Acidic Protein; D006624:Hippocampus; D008297:Male; D009473:Neuronal Plasticity; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C; D051381:Rats; ... | Brain research | 1,993 | D005904:Glial Fibrillary Acidic Protein; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C; D000110:Acetylcholinesterase |
Use of allergen bronchoprovocation to screen drugs for anti-asthma activity. | In the atopic patient with asthma, allergens are an important cause of chronic airway inflammation and symptoms. Natural exposure to seasonal allergens, such as grass pollen, may result in exacerbation of asthma, increased airway responsiveness (i.e., increased susceptibility of the airways to constrict), and an increa... | 9,017,787 | D000485:Allergens; D018927:Anti-Asthmatic Agents; D001249:Asthma; D001985:Bronchial Provocation Tests; D004341:Drug Evaluation; D006801:Humans | Pharmacotherapy | 1,997 | D000485:Allergens; D018927:Anti-Asthmatic Agents | |
Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact. | Because heme is a major iron-containing molecule in vertebrates, the ability to use heme-bound iron is a determining factor in successful infection by bacterial pathogens. Until today, all known enzymes performing iron extraction from heme did so through the rupture of the tetrapyrrol skeleton. Here, we identified 2 Es... | 10.1073/pnas.0903842106 | 19,564,607 | D027682:Cation Transport Proteins; D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D006418:Heme; D007501:Iron; D033862:Iron-Binding Proteins; D013058:Mass Spectrometry; D011485:Protein Binding; D011524:Protoporphyrins; D045725:Tetrapyrroles | Proceedings of the National Academy of Sciences of the United States of America | 2,009 | D027682:Cation Transport Proteins; C543327:EfeB protein, E coli; D029968:Escherichia coli Proteins; D033862:Iron-Binding Proteins; D011524:Protoporphyrins; D045725:Tetrapyrroles; C543326:YfeX protein, E coli; D006418:Heme; C028025:protoporphyrin IX; D007501:Iron |
How to manage yourself and the surveyor. | Hospital surveys have traditionally been the nemesis of hospital personnel. With proper management and increased awareness, however, a survey can produce positive results and attitudes for both surveyor and hospital staff. Knowledge of effective tactics can turn the "survey-weary" into the "survey-wise." | 7,419,395 | D000068:Accreditation; D006739:Hospital Administration; D006801:Humans; D007400:Interprofessional Relations; D008004:Licensure; D008006:Licensure, Hospital; D010564:Personnel, Hospital; D011584:Psychology | Health care management review | 1,980 | ||
Cisplatin induces cell cycle arrest and senescence via upregulating P53 and P21 expression in HepG2 cells. | OBJECTIVE
Cellular senescence as one of the important steps against tumor is observed in many cancer patients receiving chemotherapy and is related to chemotherapeutic response. To investigate the effect of cisplatin on hepatocellular carcinoma, we treated HepG2 cells exhibiting wild-type TP53 with gradient concentrati... | 24,067,199 | D002453:Cell Cycle; D059447:Cell Cycle Checkpoints; D016922:Cellular Senescence; D002945:Cisplatin; D050764:Cyclin-Dependent Kinase Inhibitor p19; D050759:Cyclin-Dependent Kinase Inhibitor p21; D056945:Hep G2 Cells; D006801:Humans; D016159:Tumor Suppressor Protein p53; D015854:Up-Regulation | Nan fang yi ke da xue xue bao = Journal of Southern Medical University | 2,013 | C493956:CDKN1A protein, human; C493974:CDKN2D protein, human; D050764:Cyclin-Dependent Kinase Inhibitor p19; D050759:Cyclin-Dependent Kinase Inhibitor p21; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D002945:Cisplatin | |
Anti-Oxidative Effect of Myrtenal in Prevention and Treatment of Colon Cancer Induced by 1, 2-Dimethyl Hydrazine (DMH) in Experimental Animals. | Colon cancer is considered as the precarious forms of cancer in many developed countries, with few to no symptoms; the tumor is often diagnosed in the later stages of cancer. Monoterpenes are a major part of plant essential oils found largely in fruits, vegetables and herbs. The cellular and molecular activities show t... | 10.4062/biomolther.2015.039 | 26,336,588 | Biomolecules & therapeutics | 2,015 | ||
Multiple Cardiovascular Risk Factors Indicate Cardiovascular Disease in Stage 1 Hypertension. | In November 2017, the American College of Cardiology and American Heart Association released new guidelines on hypertension that lowered the blood pressure (BP) definition of stage 1. Impedance cardiography (ICG) has shown that ventricular, vascular, and hemodynamic abnormalities are prevalent in adults over 40 years o... | 10.1007/s40292-019-00304-w | 30,719,630 | D000328:Adult; D000959:Antihypertensive Agents; D001794:Blood Pressure; D002307:Cardiography, Impedance; D000066491:Clinical Decision-Making; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension; D008297:Male; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcom... | High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension | 2,019 | D000959:Antihypertensive Agents |
The genetic basis of cognition. | The molecular characterization of single-gene disorders or chromosomal abnormalities that result in a cognitive abnormality (predominantly mental retardation) and of the genetic variants responsible for variation in intellectual abilities (such as IQ, language impairment and dyslexia) is expected to provide new insight... | 10.1093/brain/122.11.2015 | 10,545,388 | D000818:Animals; D003071:Cognition; D003072:Cognition Disorders; D005824:Genetics, Behavioral; D006801:Humans; D008607:Intellectual Disability; D007360:Intelligence; D007858:Learning; D008568:Memory | Brain : a journal of neurology | 1,999 | |
Differences in cognitive impairment of relapsing remitting, secondary, and primary progressive MS. | OBJECTIVE
To investigate the cognitive skills of patients with relapsing remitting multiple sclerosis (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS) relative to healthy control subjects and to assess whether there is heterogeneity in the type of cognitive disabilities demonstrated by patient... | 10.1212/01.wnl.0000129828.03714.90 | 15,277,630 | D000328:Adult; D000368:Aged; D003072:Cognition Disorders; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive; D020529:Multiple Sclerosis, Relapsing-Remitting; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012... | Neurology | 2,004 | |
Alkylphenol xenoestrogens with varying carbon chain lengths differentially and potently activate signaling and functional responses in GH3/B6/F10 somatomammotropes. | BACKGROUND
Alkylphenols varying in their side-chain lengths [ethyl-, propyl-, octyl-, and nonylphenol (EP, PP, OP, and NP, respectively)] and bisphenol A (BPA) represent a large group of structurally related xenoestrogens that have endocrine-disruptive effects. Their rapid nongenomic effects that depend on structure fo... | 10.1289/ehp.0800182 | 19,479,013 | D000818:Animals; D001559:Benzhydryl Compounds; D002118:Calcium; D020013:Calcium Signaling; D002460:Cell Line; D049109:Cell Proliferation; D004958:Estradiol; D010636:Phenols; D010766:Phosphorylation; D010911:Pituitary Neoplasms; D011388:Prolactin; D011863:Radioimmunoassay; D051381:Rats | Environmental health perspectives | 2,009 | D001559:Benzhydryl Compounds; D010636:Phenols; D004958:Estradiol; D011388:Prolactin; C006780:bisphenol A; D002118:Calcium |
Conductive hearing loss effects on children's language and scholastic skills. A review of the literature. | A review of available studies investigating the consequences of conductive hearing loss for language acquisition and scholastic performance was carried out. It uncovered no study that met the standards of rigor needed to provide a definitive answer to this question, although the burden of the evidence is that a persist... | 10.1177/00034894790880s502 | 115,361 | D000124:Achievement; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D034381:Hearing Loss; D006314:Hearing Loss, Conductive; D006801:Humans; D007360:Intelligence; D007805:Language Development Disorders; D007806:Language Disorders; D008297:Male; D010033:Otitis Media; D010551:Personality; D01... | The Annals of otology, rhinology & laryngology. Supplement | 1,979 | |
Serum levels of the adipokine progranulin depend on renal function. | OBJECTIVE
Progranulin has recently been introduced as a novel adipokine inducing insulin resistance and obesity. In the current study, we investigated renal elimination, as well as association of the adipokine with markers of the metabolic syndrome.
RESEARCH DESIGN AND METHODS
Progranulin serum levels were quantified... | 10.2337/dc12-0220 | 23,033,238 | D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007668:Kidney; D007677:Kidney Function Tests; D008297:Male; D015999:Multivariate Analysis; D000077153:Progranulins | Diabetes care | 2,013 | C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins |
Improvement of DGGE analysis by modifications of PCR protocols for analysis of microbial community members with low abundance. | Denaturing gradient gel electrophoresis (DGGE) is a powerful technique to reveal the community structures and composition of microorganisms in complex natural environments and samples. However, positive and reproducible polymerase chain reaction (PCR) products, which are difficult to acquire for some specific samples d... | 10.1007/s00253-014-5734-3 | 24,728,758 | D058448:Biota; D058645:Denaturing Gradient Gel Electrophoresis; D004783:Environmental Microbiology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA | Applied microbiology and biotechnology | 2,014 | |
Changing Epidemiology of Hepatitis A in China: Evidence From Three National Serological Surveys and the National Notifiable Disease Reporting System. | BACKGROUND AND AIMS
China has conducted surveillance for hepatitis A since 1990, and hepatitis A was highly-to-intermediately endemic in 1992 when a Chinese hepatitis A vaccine (HepA) was licensed and introduced as a family-pay vaccine. In 2008, HepA was introduced into the Expanded Program on Immunization as a free ch... | 10.1002/hep.31429 | 32,592,242 | D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China; D018563:Disease Notification; D005260:Female; D006506:Hepatitis A; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D017957:Hepatitis A Virus, Human; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D... | Hepatology (Baltimore, Md.) | 2,021 | D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines |
Evidence for the "grasshopper" effect and fractionation during long-range atmospheric transport of organic contaminants. | Although there is indisputable evidence that long-range atmospheric transport (LRAT) of organic contaminants occurs on a global scale, uncertainties remain about the detailed mechanism and extent of this phenomenon as well as the physical-chemical properties which facilitate LRAT. In this study, we discuss how mass bal... | 10.1016/j.envpol.2003.08.025 | 14,667,724 | D000392:Air Movements; D000393:Air Pollutants; D000397:Air Pollution; D005591:Chemical Fractionation; D004784:Environmental Monitoring; D006581:Hexachlorobenzene; D008962:Models, Theoretical; D009010:Monte Carlo Method; D009930:Organic Chemicals; D011078:Polychlorinated Biphenyls | Environmental pollution (Barking, Essex : 1987) | 2,004 | D000393:Air Pollutants; D009930:Organic Chemicals; D006581:Hexachlorobenzene; D011078:Polychlorinated Biphenyls; C014024:2,4,5,2',4',5'-hexachlorobiphenyl |
X-ray mosaic nanotomography of large microorganisms. | Full-field X-ray microscopy is a valuable tool for 3D observation of biological systems. In the soft X-ray domain organelles can be visualized in individual cells while hard X-ray microscopes excel in imaging of larger complex biological tissue. The field of view of these instruments is typically 10(3) times the spatia... | 10.1016/j.jsb.2011.12.014 | 22,227,096 | D000818:Animals; D001181:Arthropods; D021621:Imaging, Three-Dimensional; D008853:Microscopy; D008858:Microscopy, Phase-Contrast; D017356:Synchrotrons; D041962:Thiotrichaceae; D014056:Tomography, X-Ray | Journal of structural biology | 2,012 | |
Psychogenic seizures in old age: a case report. | Psychogenic seizures are unusual after age 60 years. A 73-year-old woman had onset of psychogenic seizures at age 69 years. Five to six attacks occurred each month, usually at night, characterized by an initial subjective sensation and headache followed by generalized stiffening and shaking. Continuous EEG-closed circu... | 10.1111/j.1528-1157.1993.tb02133.x | 8,243,356 | D000367:Age Factors; D000368:Aged; D002648:Child; D002649:Child Abuse; D002650:Child Abuse, Sexual; D003291:Conversion Disorder; D003937:Diagnosis, Differential; D017579:Domestic Violence; D004569:Electroencephalography; D004827:Epilepsy; D005260:Female; D006801:Humans; D012640:Seizures; D012890:Sleep; D014743:Videotap... | Epilepsia | 1,993 | |
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. | In a search for more selective A1 adenosine receptor agonists, N6-[(R)-(-)-1-methyl-2-phenethyl]-1-deazaadenosine (1-deaza-R-PIA, 3a), N6-cyclopentyl-1-deazaadenosine (1-deazaCPA, 3b), N6-cyclohexyl-1-deazaadenosine (1-deazaCHA, 3c), and the corresponding 2-chloro derivatives 2a-c were synthesized from 5,7-dichloro-3-b... | 10.1021/jm00401a018 | 3,373,486 | D000241:Adenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D000262:Adenylyl Cyclases; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents; D002417:Cattle; D006801:Humans; D051381:Rats; D011983:Receptors, Purinergic; D013329:Structure-Activity Relationship; D014372:Tubercidin | Journal of medicinal chemistry | 1,988 | D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D011983:Receptors, Purinergic; C048086:1-deazaadenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D000262:Adenylyl Cyclases; D000241:Adenosine; D014372:Tubercidin |
Effect of image compression on telepathology. A randomized clinical trial. | CONTEXT
For practitioners deploying store-and-forward telepathology systems, optimization methods such as image compression need to be studied.
OBJECTIVE
To determine if Joint Photographic Expert Group (JPG or JPEG) compression, a glossy image compression algorithm, negatively affects the accuracy of diagnosis in tel... | 10.5858/2000-124-1653-EOICOT | 11,079,019 | D003936:Diagnosis, Computer-Assisted; D004311:Double-Blind Method; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015588:Observer Variation; D010336:Pathology; D015203:Reproducibility of Results; D019113:Telepathology | Archives of pathology & laboratory medicine | 2,000 | |
Germanium as a scalable sacrificial layer for nanoscale protein patterning. | We demonstrate the use of germanium (Ge) films as water-soluble features that allow the patterning of proteins onto surfaces with commonly used organic solvents. This technique is scalable for manufacturing and is compatible with nano- and microfabrication processes, including standard lithography. We use Ge as a sacri... | 10.1371/journal.pone.0195062 | 29,624,587 | D005857:Germanium; D006861:Hydrogen Peroxide; D011506:Proteins; D012995:Solubility; D012997:Solvents; D014867:Water | PloS one | 2,018 | D011506:Proteins; D012997:Solvents; D005857:Germanium; D014867:Water; D006861:Hydrogen Peroxide |
Diagnosis of leprosy: serological aspects. | The most convenient way of diagnosing an infectious disease is by serological methods. To improve the quality of diagnosis in leprosy, simple tests in addition to diagnosis by clinical signs, are necessary. Here, PGL-I based methods for detection of multibacillary and paucibacillary leprosy, have been revisited and new... | 10.5025/hansen.75.285 | 17,037,385 | D000942:Antigens, Bacterial; D004797:Enzyme-Linked Immunosorbent Assay; D006017:Glycolipids; D006801:Humans; D007918:Leprosy; D008565:Membrane Proteins; D009166:Mycobacterium leprae; D012698:Serologic Tests | Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association | 2,006 | D000942:Antigens, Bacterial; D006017:Glycolipids; D008565:Membrane Proteins; C500901:major membrane protein II, Mycobacterium leprae; C045169:phenolic glycolipid I, Mycobacterium leprae |
[CKD-MBD and cardiovascular disease.] | Cardiovascular disease(CVD)is a crucial cause of death in patients with chronic kidney disease and various factors play a role in the progression of CVD. Among the various factors, mineral bone disorder has been focused on in recent year. Phosphate is an important factor because it affects cardiovascular system not onl... | 10.20837/4201902179 | 30,679,398 | D002318:Cardiovascular Diseases; D012080:Chronic Kidney Disease-Mineral and Bone Disorder; D006801:Humans; D010281:Parathyroid Hormone; D010710:Phosphates; D051436:Renal Insufficiency, Chronic | Clinical calcium | 2,019 | D010281:Parathyroid Hormone; D010710:Phosphates |
Spatial attention does not strongly modulate neuronal responses in early human visual cortex. | Attention can dramatically enhance behavioral performance based on a visual stimulus, but the degree to which attention modulates activity in early visual cortex is unclear. Whereas single-unit studies of spatial attention in monkeys have repeatedly revealed relatively modest attentional modulations in V1, human functi... | 10.1523/JNEUROSCI.2944-07.2007 | 18,045,914 | D001288:Attention; D005074:Evoked Potentials, Visual; D006801:Humans; D009474:Neurons; D009949:Orientation; D010775:Photic Stimulation; D011601:Psychophysics; D013028:Space Perception; D014793:Visual Cortex | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,007 | |
Scottish outcomes for extra hepatic biliary atresia post-rationalisation of services. | AIMS
To evaluate the outcome of Scottish children with extra hepatic biliary atresia (EHBA) since rationalisation of Kasai services to three English centres in 2002 (The 'Group A' centres).
METHODS
All Scottish children with EHBA diagnosed between 2002 and 2009 were identified via the Scottish Society of Paediatric G... | 10.1136/archdischild-2011-301608 | 23,429,893 | D000367:Age Factors; D001656:Biliary Atresia; D004739:England; D018166:Health Care Reform; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011171:Portoenterostomy, Hepatic; D012017:Referral and Consultation; D012041:Regional Medical Programs; D012606:Scotland; D016019:Survival Analysis; D016896:Treatment Outc... | Archives of disease in childhood | 2,013 | |
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer. | Photodynamic therapy (PDT) and chemotherapy show clinical promise in destroying orthotopic tumors but are insufficient against abscopal metastases. The research reports the combined application of an anti-CD73 antibody and chemo-PDT to synergistically amplify the anti-metastatic effects of T cell-mediated antitumor imm... | 10.1016/j.jconrel.2021.07.021 | 34,274,385 | D032701:Biomimetics; D045744:Cell Line, Tumor; D004317:Doxorubicin; D006801:Humans; D053758:Nanoparticles; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D064726:Triple Negative Breast Neoplasms | Journal of controlled release : official journal of the Controlled Release Society | 2,021 | D017319:Photosensitizing Agents; D004317:Doxorubicin |
Improved separation of creatine kinase isoenzymes by use of DEAE-Sepharose Cl-6B. | We describe here a simple, rapid chromatographic procedure for quantitatively separating serum creatine kinase isoenzymes (EC 2.7.3.2), with diethylaminoethyl (DEAE)-Sepharose CL-6B as the anion-exchanger. We established the column bed height and the elution parameters by use of a simplex procedure. DEAE-Sepharose CL-6... | 7,261,307 | D000818:Animals; D002852:Chromatography, Ion Exchange; D003402:Creatine Kinase; D006801:Humans; D007527:Isoenzymes; D009206:Myocardium; D010215:Papio; D011134:Polysaccharides; D012016:Reference Values; D012685:Sepharose | Clinical chemistry | 1,980 | D007527:Isoenzymes; D011134:Polysaccharides; D012685:Sepharose; D003402:Creatine Kinase | |
Modeling Type 1 Diabetes Using Pluripotent Stem Cell Technology. | Induced pluripotent stem cell (iPSC) technology is increasingly being used to create in vitro models of monogenic human disorders. This is possible because, by and large, the phenotypic consequences of such genetic variants are often confined to a specific and known cell type, and the genetic variants themselves can be... | 10.3389/fendo.2021.635662 | 33,868,170 | D000818:Animals; D000938:Antigen-Presenting Cells; D017209:Apoptosis; D001323:Autoantibodies; D001327:Autoimmune Diseases; D002454:Cell Differentiation; D003713:Dendritic Cells; D003922:Diabetes Mellitus, Type 1; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:... | Frontiers in endocrinology | 2,021 | D001323:Autoantibodies |
Sildenafil Exposure in the Neonatal Intensive Care Unit. | OBJECTIVE
Pulmonary hypertension causes substantial morbidity and mortality in infants. Although Food and Drug Administration approved to treat pulmonary arterial hypertension in adults, sildenafil is not approved for infants. We sought to describe sildenafil exposure and associated diagnoses and outcomes in infants.
... | 10.1055/s-0038-1667378 | 30,081,404 | D001997:Bronchopulmonary Dysplasia; D004363:Drug Utilization; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D007363:Intensive Care Units, Neonatal; D008297:Male; D008471:Meconium Aspiration Syndrome; D012189:Retr... | American journal of perinatology | 2,019 | D014665:Vasodilator Agents; D000068677:Sildenafil Citrate |
All-Optical Manipulation of Magnetization in Ferromagnetic Thin Films Enhanced by Plasmonic Resonances. | In this paper, we report all-optical manipulation of magnetization in ferromagnetic Co/Pt thin films enhanced by plasmonic resonances. By annealing a thin Au layer, we fabricate large-area Au nanoislands on top of the Co/Pt magnetic thin films, which show plasmonic resonances around the wavelength of 606 nm. Using a cu... | 10.1021/acs.nanolett.0c02089 | 32,787,165 | Nano letters | 2,020 | ||
Comparison of breast carcinomas diagnosed in the 1980s with those diagnosed in the 1940s to 1960s. | OBJECTIVE
To find out if breast carcinomas diagnosed in the 1980s differ from those diagnosed a few decades ago.
DESIGN
Retrospective comparative cohort study.
SETTING
City of Turku, south western Finland.
PATIENTS
439 patients with breast carcinoma diagnosed in 1945-65 with a median follow up of 27 years (95% of... | 10.1136/bmj.303.6795.155 | 1,878,638 | D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms; D015331:Cohort Studies; D004273:DNA, Neoplasm; D005260:Female; D005387:Finland; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D... | BMJ (Clinical research ed.) | 1,991 | D004273:DNA, Neoplasm |
Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance. | Plasmid acquisition is an important mechanism of rapid adaptation and niche expansion in prokaryotes. Positive selection for plasmid-coded functions is a major driver of plasmid evolution, while plasmids that do not confer a selective advantage are considered costly and expected to go extinct. Yet, plasmids are ubiquit... | 10.1038/s41467-019-10600-7 | 31,197,163 | D000220:Adaptation, Biological; D000900:Anti-Bacterial Agents; D056915:DNA Copy Number Variations; D019020:Directed Molecular Evolution; D004352:Drug Resistance, Microbial; D004926:Escherichia coli; D016680:Genome, Bacterial; D010957:Plasmids; D013696:Temperature | Nature communications | 2,019 | D000900:Anti-Bacterial Agents |
Inhibition of dras2/rop expression in Xenopus oocytes by Drosophila nuclear extract. | Chloramphenicol acetyl transferase reporter plasmids driven by the Drosophila ras2/rop promoter were injected into Xenopus oocytes to study Dras2 and rop gene regulation by their bidirectional promoter. When injected without Drosophila nuclear extract, both Dras2 and rep were highly expressed. Dras2 and rop-CAT express... | 10.3892/ijo.7.5.1203 | 21,552,952 | International journal of oncology | 1,995 | ||
Impact assessment of metals on soils from Machu Picchu archaeological site. | Machu Picchu is an archaeological Inca sanctuary from the 15th century, located 2430 m above the sea level in the Cusco Region, Peru. In 1983, it was declared World Heritage Site by UNESCO. The surroundings and soils from the entire archaeological site are carefully preserved together with its grass parks. Due to the i... | 10.1016/j.chemosphere.2019.125249 | 31,896,203 | D002947:Cities; D004784:Environmental Monitoring; D008670:Metals; D019216:Metals, Heavy; D010568:Peru; D012987:Soil; D012989:Soil Pollutants; D014961:X-Ray Diffraction | Chemosphere | 2,020 | D008670:Metals; D019216:Metals, Heavy; D012987:Soil; D012989:Soil Pollutants |
Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma. | Molecular imaging approaches for metabolic and physiologic imaging of tumors have become important for treatment planning and response monitoring. However, the relationship between the physiologic and metabolic aspects of tumors is not fully understood. Here, we developed new hyperpolarized MRI and electron paramagneti... | 10.1158/0008-5472.CAN-19-0928 | 32,245,793 | D000818:Animals; D014408:Biomarkers, Tumor; D021441:Carcinoma, Pancreatic Ductal; D045744:Cell Line, Tumor; D004578:Electron Spin Resonance Spectroscopy; D019788:Fluorodeoxyglucose F18; D005947:Glucose; D006019:Glycolysis; D064593:Heterografts; D006801:Humans; D051379:Mice; D057054:Molecular Imaging; D010100:Oxygen; D0... | Cancer research | 2,020 | D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose; D010100:Oxygen |
Unusual Intravesical Foreign Body Following Perineo-vesical Injury. | Reports of foreign body in the bladder are rare. Various objects have been retrieved. Diagnosis is mainly by history of lower urinary tract symptoms and low abdominal pain combined with relevant radiological investigations. Treatment depends on the size, nature, and configuration of the object. The approach may be endo... | 10.4103/njs.NJS_2_17 | 29,643,734 | Nigerian journal of surgery : official publication of the Nigerian Surgical Research Society | 2,018 | ||
Topographic analysis of astigmatism induced by scleral shortening in pig eyes. | BACKGROUND
Corneal astigmatism is a severe postoperative problem in foveal translocation surgery. We evaluated the corneal astigmatism induced by scleral shortening in pig eyes in vitro.
METHODS
We created three sizes of scleral shortening in pig eyes and examined the preoperative and postoperative corneal astigmatis... | 10.1007/s004170100265 | 11,482,343 | D000818:Animals; D001251:Astigmatism; D003315:Cornea; D019781:Corneal Topography; D015353:Eye Enucleation; D005584:Fovea Centralis; D011183:Postoperative Complications; D012590:Sclera; D012591:Scleral Buckling; D013552:Swine | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie | 2,001 | |
MRI-derived cardiac washout is slowed in the left ventricle and associated with left ventricular non-compaction in young patients with cryptogenic ischemic stroke. | To elucidate underlying disease mechanisms, we compared transition of gadolinium-based contrast agent bolus in cardiac chambers in magnetic resonance imaging between young patents with cryptogenic ischemic stroke and stroke-free controls. We included 30 patients aged 18-50 years with cryptogenic ischemic stroke from th... | 10.1007/s10554-022-02643-7 | 36,434,329 | D006801:Humans; D003287:Contrast Media; D006325:Heart Atria; D006352:Heart Ventricles; D000083242:Ischemic Stroke; D008279:Magnetic Resonance Imaging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D020521:Stroke; D014683:Vena Cava, Superior; D008297:Male; D005260:Female; D000293:Adolescent; D055815:Yo... | The international journal of cardiovascular imaging | 2,022 | D003287:Contrast Media |
Comparison of happiness in students of a public and private university in Peru. | BACKGROUND
Happiness is a positive component of mental well-being. In young university students, it is linked to ideals in many areas, such as physical health, mental health, harmonious inter-personal relationships, academic performance, and professional success. The aim of the study was to compare the happiness of uni... | 10.4103/jehp.jehp_1485_22 | 37,546,012 | Journal of education and health promotion | 2,023 | ||
Barriers and facilitators for Māori in accessing hospital services in Aotearoa New Zealand. | AIM
This paper reports the findings of a literature review to answer the research question, "What are the barriers and facilitators of access to hospital services for Māori?"
METHOD
MEDLINE (Ovid) and PsycINFO were searched using keywords to identify relevant literature published between 2000 and 2020. The data analy... | 34,855,733 | D006297:Health Services Accessibility; D006303:Health Services, Indigenous; D006761:Hospitals; D006801:Humans; D044468:Native Hawaiian or Other Pacific Islander; D009520:New Zealand; D011634:Public Health | The New Zealand medical journal | 2,021 | ||
Using machine vision to analyze and classify Caenorhabditis elegans behavioral phenotypes quantitatively. | Mutants with abnormal patterns of locomotion, also known as uncoordinated (Unc) mutants, have facilitated the genetic dissection of many important aspects of nervous system function and development in the nematode Caenorhabditis elegans. Although a large number of distinct classes of Unc mutants can be distinguished by... | 10.1016/s0165-0270(02)00117-6 | 12,191,753 | D000465:Algorithms; D000818:Animals; D001522:Behavior, Animal; D017173:Caenorhabditis elegans; D007091:Image Processing, Computer-Assisted; D009043:Motor Activity; D009154:Mutation; D010641:Phenotype | Journal of neuroscience methods | 2,002 | |
Do mitochondrial DNA fragments promote cancer and aging? | Reactive oxygen species are important in carcinogenesis, diseases, and aging, probably through oxidative damage of DNA. Our understanding of this relationship at the molecular level is very sketchy. It has recently been found that in mitochondria oxidative DNA damage is particularly high and may not be repaired efficie... | 10.1016/0014-5793(88)81018-4 | 3,197,826 | D000375:Aging; D002273:Carcinogens; D004249:DNA Damage; D004272:DNA, Mitochondrial; D006801:Humans; D009369:Neoplasms | FEBS letters | 1,988 | D002273:Carcinogens; D004272:DNA, Mitochondrial |
Remission of left Tawara-branch block under treatment for systemic sarcoidosis. | Diagnosis and treatment of cardiac sarcoidosis is a challenging task. The presented case illustrates the importance of systemic ECG in the management of patients with pulmonary sarcoidosis and the utility of cardiac MRI in the diagnostic procedure of cardiac involvement of the disease. It is one of the first reports em... | 10.1016/j.ijcard.2007.07.063 | 17,935,802 | D000328:Adult; D006327:Heart Block; D006801:Humans; D008297:Male; D012074:Remission Induction; D017565:Sarcoidosis, Pulmonary; D016896:Treatment Outcome | International journal of cardiology | 2,009 | |
Longitudinal evaluation of the excisional new attachment procedure in humans. | Evaluation of the Excisional New Attachment Procedure (ENAP) was extended to 3 years postoperatively. Generally, there was an overall mean increase in sulcus depth of 0.5 mm; an overall mean increase in recession of 0.1 mm; and an overall mean decrease in the amount of previously gained new attachment of 0.6 mm between... | 10.1902/jop.1978.49.3.142 | 288,901 | D004846:Epithelial Attachment; D005069:Evaluation Studies as Topic; D005881:Gingiva; D005888:Gingival Pocket; D005890:Gingivectomy; D005891:Gingivitis; D005893:Gingivoplasty; D006801:Humans; D008137:Longitudinal Studies | Journal of periodontology | 1,978 | |
Dorsal Thompson: Approach to the Proximal Radial Shaft. | Treatment principles in the management of radial shaft fractures, congruent with all fracture care, are to restore anatomy and function of the limb. Radial shaft fractures are unique in that preserving the anatomic bow of the radius, which allows for its rotation around the ulna during pronation and supination, is esse... | 10.1097/BOT.0000000000002162 | 34,227,594 | D005542:Forearm; D006801:Humans; D011403:Pronation; D011884:Radius; D011885:Radius Fractures; D013484:Supination | Journal of orthopaedic trauma | 2,021 | |
HIV and prostate cancer: a systematic review of the literature. | Malignancy occurs with increased frequency in the HIV-positive population. The true incidence of prostate cancer in this population is unknown. In the few cases that have been presented in the literature, prostate cancer in HIV-positive men appears to behave much like it does in HIV-negative men. Prostate cancer is the... | 10.1038/pcan.2008.44 | 18,711,409 | D000368:Aged; D015658:HIV Infections; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms | Prostate cancer and prostatic diseases | 2,009 | |
Highly Efficient Single-Layer Phosphorescent Organic Light-Emitting Diodes Based on Co-Host Structure. | High-efficiency single-layer organic light-emitting diodes (OLEDs) based on a simple structure doped with iridium(III) bis(4-phenylthieno[3,2-c]pyridinato-N,C2') acetylacetonate (PO-01) as emission dyes are realized, achieving maximum current efficiency (CE) and power efficiency (PE) of 37.1 cd A-1 and 33.3 lm W-1 as w... | 10.3390/ma13092029 | 32,357,480 | Materials (Basel, Switzerland) | 2,020 | ||
Diffusion tensor imaging of cerebral white matter: technique, anatomy, and pathologic patterns. | Diffusion tensor imaging is a magnetic resonance imaging technique that provides insight into the anatomy and integrity of white matter pathways in the brain. Further processing of these data can help map individual tracts, which can aid in surgical planning. Understanding the basics of this technique can improve chara... | 24,582,347 | D003937:Diagnosis, Differential; D056324:Diffusion Tensor Imaging; D006801:Humans; D056784:Leukoencephalopathies | Radiologic clinics of North America | 2,014 | ||
The evolving features of Nicolaides-Baraitser syndrome - a clinical report of a 20-year follow-up. | Nicolaides-Baraitser syndrome (NCBRS) is a rare genetic condition associated with SMARCA2 gene mutations. Clinical diagnosis is challenging as its features evolve with time. The 20 years follow-up of our NCBRS patient, with a previously unreported SMARCA2 mutation, illustrates the syndrome's natural history and its cli... | 10.1002/ccr3.425 | 27,099,726 | Clinical case reports | 2,016 | ||
The role of romantic relationship status in pathways of risk for emerging adult alcohol use. | Dating several people in emerging adulthood has been associated with higher alcohol use compared with being single or being in an exclusive relationship. As a follow-up to that report, we examined whether romantic relationship status is part of a pathway of risk between antecedent alcohol use risk factors and subsequen... | 10.1037/adb0000145 | 27,214,170 | D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D019973:Alcohol-Related Disorders; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008137:Longitudinal Studies; D008297:Male; D010290:Parents; D012307:Risk Factors; D012725:Sexual Behavior; D013334:Students; D014495:Universities; D055815:You... | Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors | 2,016 | |
Comfort Evaluation of Slow-Recovery Ejection Seat Cushions Based on Sitting Pressure Distribution. | Sitting discomfort not only affects the health of pilots carrying out long-endurance missions but also affects operational performance. The experimental objects included four ejection seat cushions: N1 was a fast-recovery foam as the comparison group, and the experimental groups were slow-recovery foams with different ... | 10.3389/fbioe.2021.759442 | 34,917,595 | Frontiers in bioengineering and biotechnology | 2,021 | ||
Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism. | BACKGROUND
Manifestations of core social deficits in autism are more pronounced in everyday settings than in explicit experimental tasks. To bring experimental measures in line with clinical observation, we report a novel method of quantifying atypical strategies of social monitoring in a setting that simulates the dem... | 10.1001/archpsyc.59.9.809 | 12,215,080 | D000293:Adolescent; D000328:Adult; D001288:Attention; D001321:Autistic Disorder; D005145:Face; D005403:Fixation, Ocular; D006801:Humans; D008297:Male; D011336:Probability; D012307:Risk Factors; D012917:Social Adjustment; D012919:Social Behavior; D014796:Visual Perception | Archives of general psychiatry | 2,002 | |
The cost of complexity: the teaching hospital. | There are factors other than teaching that should be considered to understand why teaching hospitals are more costly than their community hospital counterparts. Often these factors are compensated under the rubric of education. Medicare's reimbursement of direct and indirect medical education expenses is discussed as a... | 10,311,939 | D000553:Ambulatory Care; D003625:Data Collection; D003953:Diagnosis-Related Groups; D006784:Hospitals, Teaching; D008489:Medical Indigency; D006278:Medicare; D012109:Research Support as Topic; D014481:United States | Hospital & health services administration | 1,986 | ||
Correlation between High Temperature Deformation and β Relaxation in LaCeBased Metallic Glass. | Hightemperature deformation around the glass transition temperature Tg and the dynamic mechanical behavior of La30Ce30Al15Co25 metallic glass were investigated. According to dynamic mechanical analysis (DMA) results, La30Ce30Al15Co25 metallic glass exhibits a pronounced slow β relaxation process. In parallel, strainrat... | 10.3390/ma13040833 | 32,059,531 | Materials (Basel, Switzerland) | 2,020 | ||
Phenotyping the quality of complex medium components by simple online-monitored shake flask experiments. | BACKGROUND
Media containing yeast extracts and other complex raw materials are widely used for the cultivation of microorganisms. However, variations in the specific nutrient composition can occur, due to differences in the complex raw material ingredients and in the production of these components. These lot-to-lot var... | 10.1186/s12934-014-0149-5 | 25,376,163 | D003470:Culture Media; D004926:Escherichia coli; D011786:Quality Control | Microbial cell factories | 2,014 | D003470:Culture Media |
The effects of wound infiltration with bupivacaine versus saline on postoperative pain and opioid requirements after herniorrhaphy. | In a prospective, double-blind, placebo-controlled study, twenty-eight healthy, male patients, aged 20-69 years, scheduled for unilateral elective inguinal herniorrhaphy ad modum Bassini were randomized to receive postoperative infiltration of the surgical wound with either bupivacaine 0.25%, or isotonic saline. Genera... | 10.1111/j.1399-6576.1994.tb03891.x | 8,023,671 | D000328:Adult; D000368:Aged; D000698:Analgesia; D000771:Anesthesia, Intravenous; D002045:Bupivacaine; D003371:Cough; D004311:Double-Blind Method; D006552:Hernia, Inguinal; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle A... | Acta anaesthesiologica Scandinavica | 1,994 | D010919:Placebos; D012965:Sodium Chloride; D009020:Morphine; D002045:Bupivacaine |
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