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wikidoc
Dock4
Dock4 Dock4, (Dedicator of cytokinesis 4) also known as DOCK4, is a large (~190 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock4 activates the small ...
Dock4 Dock4, (Dedicator of cytokinesis 4) also known as DOCK4, is a large (~190 kDa) protein involved in intracellular signalling networks.[1] It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock4 activates the sm...
https://www.wikidoc.org/index.php/Dock4
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wikidoc
Dock6
Dock6 Dock6 (Dedicator of cytokinesis 6), also known as Zir1 is a large (~200 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins. # Discovery Dock6 was identified a...
Dock6 Dock6 (Dedicator of cytokinesis 6), also known as Zir1 is a large (~200 kDa) protein involved in intracellular signalling networks.[1] It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins. # Discovery Dock6 was identifi...
https://www.wikidoc.org/index.php/Dock6
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wikidoc
Dock7
Dock7 Dock7 (Dedicator of cytokinesis 7), also known as Zir2, is a large (~240 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock7 activates isoforms of...
Dock7 Dock7 (Dedicator of cytokinesis 7), also known as Zir2, is a large (~240 kDa) protein involved in intracellular signalling networks.[1] It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock7 activates isoform...
https://www.wikidoc.org/index.php/Dock7
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wikidoc
Dock8
Dock8 DOCK8 (Dedicator of cytokinesis 8), also known as Zir3, is a large (~190 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. # Discovery Dock8 was iden...
Dock8 DOCK8 (Dedicator of cytokinesis 8), also known as Zir3, is a large (~190 kDa) protein involved in intracellular signalling networks.[1] It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. # Discovery Dock8 was ...
https://www.wikidoc.org/index.php/Dock8
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wikidoc
Dock9
Dock9 Dock9 (Dedicator of cytokinesis 9), also known as Zizimin1, is a large (~230 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors that function as activators of small G proteins. Dock9 activates the small G pro...
Dock9 Dock9 (Dedicator of cytokinesis 9), also known as Zizimin1, is a large (~230 kDa) protein involved in intracellular signalling networks.[1] It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors that function as activators of small G proteins. Dock9 activates the small G...
https://www.wikidoc.org/index.php/Dock9
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wikidoc
Doubt
Doubt # Overview Doubt, a status between belief and disbelief, involves uncertainty or distrust or lack of sureness of a fact, an action, a motive, or a decision. Doubt brings into question some notion of a perceived "reality", and may involve delaying relevant action out of concerns for mistakes or faults. The term "...
Doubt Template:Emotion Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] # Overview Doubt, a status between belief and disbelief, involves uncertainty or distrust or lack of sureness of a fact, an action, a motive, or a decision. Doubt brings into question some notion of a perceived "reality", and may involve delayi...
https://www.wikidoc.org/index.php/Doubt
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wikidoc
Doula
Doula A doula is a non-medical assistant who provides physical, emotional and informational support in prenatal care, during childbirth and during the postpartum period. # Etymology and history of usage The word doula comes from Greek, and refers to a woman who personally serves as slave to another man or woman. In Gr...
Doula A doula is a non-medical assistant who provides physical, emotional and informational support in prenatal care, during childbirth and during the postpartum period. # Etymology and history of usage The word doula comes from Greek, and refers to a woman who personally serves as slave to another man or woman. In G...
https://www.wikidoc.org/index.php/Doula
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wikidoc
Dylar
Dylar Dylar is a fictional psychoactive drug that appears in Don DeLillo's novel White Noise. Dylar is intended to remove the fear of death. However, the drug does not work properly and extended use sometimes results in insanity. Extended users interpret spoken words and metaphor as actual actions and events. In an i...
Dylar Dylar is a fictional psychoactive drug that appears in Don DeLillo's novel White Noise. Dylar is intended to remove the fear of death. However, the drug does not work properly and extended use sometimes results in insanity. Extended users interpret spoken words and metaphor as actual actions and events. In an ...
https://www.wikidoc.org/index.php/Dylar
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wikidoc
EC-No
EC-No The terms EC-No and EC# refer to the seven-digit code (sometimes called the EC number) that has been allocated by the Commission of the European Communities for commercially available chemical substances within the European Union. The European EC Number should not be confused with the Enzyme Commission EC number ...
EC-No The terms EC-No and EC# refer to the seven-digit code (sometimes called the EC number) that has been allocated by the Commission of the European Communities for commercially available chemical substances within the European Union. The European EC Number should not be confused with the Enzyme Commission EC number...
https://www.wikidoc.org/index.php/EC-No
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wikidoc
ECGF1
ECGF1 Thymidine phosphorylase is an enzyme that in humans is encoded by the TYMP gene. Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell speci...
ECGF1 Thymidine phosphorylase is an enzyme that in humans is encoded by the TYMP gene.[1][2] Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cel...
https://www.wikidoc.org/index.php/ECGF1
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wikidoc
ECHS1
ECHS1 Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, also known as ECHS1, is a human gene. The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs....
ECHS1 Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, also known as ECHS1, is a human gene.[1] The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-C...
https://www.wikidoc.org/index.php/ECHS1
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wikidoc
ECSIT
ECSIT Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT), also known as SITPEC, is a protein that in humans is encoded by the ECSIT gene. ECSIT is a cytosolic adaptor protein involved in inflammatory responses, embryonic development, and the assembly and stabilization of mitochondria...
ECSIT Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT), also known as SITPEC, is a protein that in humans is encoded by the ECSIT gene.[1] ECSIT is a cytosolic adaptor protein involved in inflammatory responses, embryonic development, and the assembly and stabilization of mitochon...
https://www.wikidoc.org/index.php/ECSIT
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wikidoc
EEF1D
EEF1D Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene. # Function This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is re...
EEF1D Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene.[1] # Function This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It i...
https://www.wikidoc.org/index.php/EEF1D
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wikidoc
EEF2K
EEF2K Eukaryotic elongation factor-2 kinase (eEF-2 kinase or eEF-2K), also known as calmodulin-dependent protein kinase III (CAMKIII) and calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase, is an enzyme that in humans is encoded by the EEF2K gene. # Function eEF-2 kinase is a highly conserved protein k...
EEF2K Eukaryotic elongation factor-2 kinase (eEF-2 kinase or eEF-2K), also known as calmodulin-dependent protein kinase III (CAMKIII) and calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase,[1] is an enzyme that in humans is encoded by the EEF2K gene.[2][3] # Function eEF-2 kinase is a highly conserved...
https://www.wikidoc.org/index.php/EEF2K
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wikidoc
EFHC2
EFHC2 EF-hand domain (C-terminal) containing 2 is a protein that in humans is encoded by the EFHC2 gene. # Gene EFHC2 is located on the negative strand (sense strand) of the X chromosome at p11.3. EFHC2 is also one of a few, select number of genes with in vitro evidence suggesting that it escapes X inactivation. EFHC2...
EFHC2 EF-hand domain (C-terminal) containing 2 is a protein that in humans is encoded by the EFHC2 gene.[1][2] # Gene EFHC2 is located on the negative strand (sense strand) of the X chromosome at p11.3. EFHC2 is also one of a few, select number of genes with in vitro evidence suggesting that it escapes X inactivation...
https://www.wikidoc.org/index.php/EFHC2
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wikidoc
EGFL7
EGFL7 EGF-like domain-containing protein 7 is a protein that in humans is encoded by the EGFL7 gene. Intron 7 of EGFL7 hosts the miR-126 microRNA gene. # Gene Epidermal Growth Factor like domain 7 (Egfl7) also known as Vascular Endothelial-statin (VE-statin) codes for a gene mostly expressed in endothelial cells. The ...
EGFL7 EGF-like domain-containing protein 7 is a protein that in humans is encoded by the EGFL7 gene.[1] Intron 7 of EGFL7 hosts the miR-126 microRNA gene. # Gene Epidermal Growth Factor like domain 7 (Egfl7) also known as Vascular Endothelial-statin (VE-statin) codes for a gene mostly expressed in endothelial cells.[...
https://www.wikidoc.org/index.php/EGFL7
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wikidoc
EGLN1
EGLN1 Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme encoded by the EGLN1 gene. It is also known as Egl nine homolog 1. PHD2 is a α-ketoglutarate/2-oxoglutarate-dependent hydroxylase, a superfamily non-haem iron-containing proteins. In hum...
EGLN1 Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme encoded by the EGLN1 gene. It is also known as Egl nine homolog 1.[1][2][3][4] PHD2 is a α-ketoglutarate/2-oxoglutarate-dependent hydroxylase, a superfamily non-haem iron-containing pro...
https://www.wikidoc.org/index.php/EGLN1
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wikidoc
EGLN2
EGLN2 Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene. ELGN2 is a alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins. The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, t...
EGLN2 Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene.[1] ELGN2 is a alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins. The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen level...
https://www.wikidoc.org/index.php/EGLN2
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wikidoc
EHMT1
EHMT1 Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded by the EHMT1 gene. # Function The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methyla...
EHMT1 Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded by the EHMT1 gene.[1] # Function The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein met...
https://www.wikidoc.org/index.php/EHMT1
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wikidoc
EHMT2
EHMT2 Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a, is a histone methyltransferase enzyme that in humans is encoded by the EHMT2 gene. G9a catalyzes the mono- and di-methylated states of histone H3 at lysine residue 9 (i.e., H3K9me1 and H3K9me2) and lysine residue 27 (H3K27me1 and HeK27me...
EHMT2 Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a, is a histone methyltransferase enzyme that in humans is encoded by the EHMT2 gene.[1][2][3] G9a catalyzes the mono- and di-methylated states of histone H3 at lysine residue 9 (i.e., H3K9me1 and H3K9me2) and lysine residue 27 (H3K27me1 a...
https://www.wikidoc.org/index.php/EHMT2
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wikidoc
eIF-2
eIF-2 eIF-2 (Eukaryotic Initiation Factor 2) is a heterotrimer of subunits alpha, beta, and gamma. eIF-2 mediates the binding of methionyl-tRNAimet to the ribosome in a GTP-dependent manner. eIF-2 is released from the ribosome bound to GDP as an inactive binary complex. To participate in another round of translation in...
eIF-2 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] eIF-2 (Eukaryotic Initiation Factor 2) is a heterotrimer of subunits alpha, beta, and gamma. eIF-2 mediates the binding of methionyl-tRNAimet to the ribosome in a GTP-dependent manner. eIF-2 is released from the ribosome bound to GDP as an inactive binary comple...
https://www.wikidoc.org/index.php/EIF-2
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wikidoc
EIF3K
EIF3K Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene. # Function The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by bindin...
EIF3K Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene.[1][2][3] # Function The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation...
https://www.wikidoc.org/index.php/EIF3K
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wikidoc
eIF4A
eIF4A The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. # Background The mechanisms go...
eIF4A The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.[1][2] # Background The mechan...
https://www.wikidoc.org/index.php/EIF4A
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wikidoc
EIF4E
EIF4E Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene. # Structure and function Most eukaryotic cellular mRNAs are blocked at their 5'-ends with the 7-methyl-guanosine five-prime cap structure, m7GpppX (where X is any nucleotide). This structur...
EIF4E Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene.[1][2] # Structure and function Most eukaryotic cellular mRNAs are blocked at their 5'-ends with the 7-methyl-guanosine five-prime cap structure, m7GpppX (where X is any nucleotide). This s...
https://www.wikidoc.org/index.php/EIF4E
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wikidoc
EIF4H
EIF4H Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene. This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisy...
EIF4H Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.[1][2][3] This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome,...
https://www.wikidoc.org/index.php/EIF4H
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wikidoc
EIF5A
EIF5A Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. It is the only known protein to contain the unusual amino acid hypusine , which is synthesized on eIF5A at a specific lysine residue from the polyamine spermidine by two catalytic steps. EF-P is the prokaryotic...
EIF5A Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene.[1] It is the only known protein to contain the unusual amino acid hypusine [N (ε)- (4-amino-2-hydroxybutyl)-lysine], which is synthesized on eIF5A at a specific lysine residue from the polyamine spermidine by ...
https://www.wikidoc.org/index.php/EIF5A
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wikidoc
ELAC2
ELAC2 Zinc phosphodiesterase ELAC protein 2 is an enzyme that in humans is encoded by the ELAC2 gene. on chromosome 17. It is an endonuclease thought to be involved in mitochondrial tRNA maturation, # Function The ELAC2 gene encodes a protein that is 92 kDa in size and is localized to the mitochondrion and the nucleu...
ELAC2 Zinc phosphodiesterase ELAC protein 2 is an enzyme that in humans is encoded by the ELAC2 gene.[1][2][3] on chromosome 17. It is an endonuclease thought to be involved in mitochondrial tRNA maturation, # Function The ELAC2 gene encodes a protein that is 92 kDa in size and is localized to the mitochondrion [4] a...
https://www.wikidoc.org/index.php/ELAC2
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wikidoc
ELMO1
ELMO1 Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. ELMO1 is located on chromosome number seven in humans and is located on chromosome number thirteen in mice. # Structure The human engulfment and cell motility protein 1, ELMO1, is 720 residues in length. The protein...
ELMO1 Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene.[1][2] ELMO1 is located on chromosome number seven in humans and is located on chromosome number thirteen in mice. # Structure The human engulfment and cell motility protein 1, ELMO1, is 720 residues in length. The ...
https://www.wikidoc.org/index.php/ELMO1
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wikidoc
EMSAM
EMSAM EMSAM® (selegiline transdermal system) is a transdermal patch using the monoamine oxidase inhibitor (MAOI) selegiline. Selegiline, in small doses, is most commonly used in the treatment of Parkinson's disease. It is also effective in higher doses for the treatment of major depessive disorder. On February 28, 20...
EMSAM EMSAM® (selegiline transdermal system) is a transdermal patch using the monoamine oxidase inhibitor (MAOI) selegiline. Selegiline, in small doses, is most commonly used in the treatment of Parkinson's disease. It is also effective in higher doses for the treatment of major depessive disorder.[1] On February 28...
https://www.wikidoc.org/index.php/EMSAM
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wikidoc
ENDOG
ENDOG Endonuclease G, mitochondrial is an enzyme that in humans is encoded by the ENDOG gene. This protein primarily participates in caspase-independent apoptosis via DNA degradation when translocating from the mitochondrion to nucleus under oxidative stress. As a result, EndoG has been implicated in cancer, aging, and...
ENDOG Endonuclease G, mitochondrial is an enzyme that in humans is encoded by the ENDOG gene.[1][2] This protein primarily participates in caspase-independent apoptosis via DNA degradation when translocating from the mitochondrion to nucleus under oxidative stress.[3] As a result, EndoG has been implicated in cancer, ...
https://www.wikidoc.org/index.php/ENDOG
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wikidoc
ENOX2
ENOX2 ENOX2 is a gene located on the long arm of the X chromosome in humans. The gene encodes the protein Ecto-NOX disulfide-thiol exchanger 2, a member of the NOX family of NADPH oxidases. Ecto-NOX disulfide-thiol exchanger 2 is a growth-related cell surface protein. It was identified because it reacts with the monocl...
ENOX2 ENOX2 is a gene located on the long arm of the X chromosome in humans.[1] The gene encodes the protein Ecto-NOX disulfide-thiol exchanger 2, a member of the NOX family of NADPH oxidases.[2][3][4] Ecto-NOX disulfide-thiol exchanger 2 is a growth-related cell surface protein. It was identified because it reacts wi...
https://www.wikidoc.org/index.php/ENOX2
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wikidoc
ENPP3
ENPP3 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is an enzyme that in humans is encoded by the ENPP3 gene. # Function The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophos...
ENPP3 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is an enzyme that in humans is encoded by the ENPP3 gene.[1][2] # Function The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP p...
https://www.wikidoc.org/index.php/ENPP3
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wikidoc
ENPP7
ENPP7 Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) also known as alkaline sphingomyelin phosphodiesterase (Alk-SMase) or intestinal alkaline sphingomyelinase is an enzyme that in humans is encoded by the ENPP7 gene. # History ENPP7 is a new name for an old enzyme whose activity was origin...
ENPP7 Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) also known as alkaline sphingomyelin phosphodiesterase (Alk-SMase) or intestinal alkaline sphingomyelinase is an enzyme that in humans is encoded by the ENPP7 gene.[1][2] # History ENPP7 is a new name for an old enzyme whose activity was...
https://www.wikidoc.org/index.php/ENPP7
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wikidoc
EP300
EP300 Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remode...
EP300 Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene.[1] It functions as histone acetyltransferase that regulates transcription of genes via chromatin re...
https://www.wikidoc.org/index.php/EP300
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wikidoc
EPAS1
EPAS1 Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2alpha)) is a protein that in humans is encoded by the EPAS1 gene. It is a type of hypoxia-inducible factor, a group of transcription factors involved in body response to oxygen level. The gene is active under l...
EPAS1 Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2alpha)) is a protein that in humans is encoded by the EPAS1 gene. It is a type of hypoxia-inducible factor, a group of transcription factors involved in body response to oxygen level.[1][2][3][4] The gene is a...
https://www.wikidoc.org/index.php/EPAS1
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wikidoc
EPHB3
EPHB3 Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene. # Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A ...
EPHB3 Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.[1][2] # Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ep...
https://www.wikidoc.org/index.php/EPHB3
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wikidoc
EPHX1
EPHX1 Epoxide hydrolase 1 is an enzyme encoded by the EPHX1 gene in humans. # Function Epoxide hydrolase plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons. # Discovery Microsomal epoxide hydrolase 1 (EPHX1) was first isolated by Watabe an...
EPHX1 Epoxide hydrolase 1 is an enzyme encoded by the EPHX1 gene in humans.[1][2] # Function Epoxide hydrolase plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons.[2] # Discovery Microsomal epoxide hydrolase 1 (EPHX1) was first isolated by...
https://www.wikidoc.org/index.php/EPHX1
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wikidoc
EPS15
EPS15 Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene. # Function This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged...
EPS15 Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.[1] # Function This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearra...
https://www.wikidoc.org/index.php/EPS15
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wikidoc
ERAP1
ERAP1 Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, also known as endoplasmic reticulum aminopeptidase 1 (ARTS-1), is a protein which in humans is encoded by the ARTS-1 gene. Endoplasmic reticulum amino peptidase 1 is active in the endoplasmic reticulum, which is involved in protein processin...
ERAP1 Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, also known as endoplasmic reticulum aminopeptidase 1 (ARTS-1), is a protein which in humans is encoded by the ARTS-1 gene.[1] Endoplasmic reticulum amino peptidase 1 is active in the endoplasmic reticulum, which is involved in protein proce...
https://www.wikidoc.org/index.php/ERAP1
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wikidoc
ERBB3
ERBB3 Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is k...
ERBB3 Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is ...
https://www.wikidoc.org/index.php/ERBB3
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wikidoc
ERBB4
ERBB4 Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized. # Function Receptor tyrosine-protein kinase erbB-4 is a receptor ty...
ERBB4 Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene.[1][2] Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.[3] # Function Receptor tyrosine-protein kinase erbB-4 is a r...
https://www.wikidoc.org/index.php/ERBB4
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wikidoc
ERCC1
ERCC1 DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene. Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination. Many aspects of these two gene products are described together here because they are partners during DNA...
ERCC1 DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene.[1] Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.[2][3] Many aspects of these two gene products are described together here because they are partners ...
https://www.wikidoc.org/index.php/ERCC1
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wikidoc
ERCC2
ERCC2 ERCC2, or XPD is a protein involved in transcription-coupled nucleotide excision repair. The XPD (ERCC2) gene encodes for a 2.3-kb mRNA containing 22 exons and 21 introns. The XPD protein is a 760 amino acids polypeptide with a size of 87kDa. Defects in this gene can result in three different disorders: the cance...
ERCC2 ERCC2, or XPD is a protein involved in transcription-coupled nucleotide excision repair. The XPD (ERCC2) gene encodes for a 2.3-kb mRNA containing 22 exons and 21 introns. The XPD protein is a 760 amino acids polypeptide with a size of 87kDa. Defects in this gene can result in three different disorders: the canc...
https://www.wikidoc.org/index.php/ERCC2
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wikidoc
ERCC4
ERCC4 ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination. The nuclease enzyme ERCC1-XPF cuts specific structures of DNA. Many aspects of these two g...
ERCC4 ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.[1][2] The nuclease enzyme ERCC1-XPF cuts specific structures of DNA. Many aspects of thes...
https://www.wikidoc.org/index.php/ERCC4
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wikidoc
ERCC5
ERCC5 DNA repair protein complementing XP-G cells is a protein that in humans is encoded by the ERCC5 gene. Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cause Cock...
ERCC5 DNA repair protein complementing XP-G cells is a protein that in humans is encoded by the ERCC5 gene.[1][2] Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cau...
https://www.wikidoc.org/index.php/ERCC5
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wikidoc
ERCC6
ERCC6 DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene. The ERCC6 gene is located on the long arm of chromosome 10 at position 11.23. Having 1 or more copies of a mutated ERCC6 causes Cockayne syndrome, type II. # Function DNA can be damaged by ultraviolet...
ERCC6 DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene.[1][2][3] The ERCC6 gene is located on the long arm of chromosome 10 at position 11.23.[4] Having 1 or more copies of a mutated ERCC6 causes Cockayne syndrome, type II. # Function DNA can be damaged b...
https://www.wikidoc.org/index.php/ERCC6
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wikidoc
PDIA3
PDIA3 Protein disulfide-isomerase A3 (PDIA3), also known as glucose-regulated protein, 58-kD (GRP58), is an isomerase enzyme. This protein localizes to the endoplasmic reticulum (ER) and interacts with lectin chaperones calreticulin and calnexin (CNX) to modulate folding of newly synthesized glycoproteins. It is though...
PDIA3 Protein disulfide-isomerase A3 (PDIA3), also known as glucose-regulated protein, 58-kD (GRP58), is an isomerase enzyme.[1][2][3] This protein localizes to the endoplasmic reticulum (ER) and interacts with lectin chaperones calreticulin and calnexin (CNX) to modulate folding of newly synthesized glycoproteins. It...
https://www.wikidoc.org/index.php/ERP57
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wikidoc
ETFDH
ETFDH Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial is an enzyme that in humans is encoded by the ETFDH gene. This gene encodes a component of the electron-transfer system in mitochondria and is essential for electron transfer from a number of mitochondrial flavin-containing dehydrogenases to ...
ETFDH Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial is an enzyme that in humans is encoded by the ETFDH gene. This gene encodes a component of the electron-transfer system in mitochondria and is essential for electron transfer from a number of mitochondrial flavin-containing dehydrogenases to...
https://www.wikidoc.org/index.php/ETFDH
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ETHE1
ETHE1 Protein ETHE1, mitochondrial, also known as "ethylmalonic encephalopathy 1 protein" and "per sulfide dioxygenase", is a protein that in humans is encoded by the ETHE1 gene located on chromosome 19. # Structure The human ETHE1 gene consists of 7 exons and encodes for a protein that is approximately 27 kDa in size...
ETHE1 Protein ETHE1, mitochondrial, also known as "ethylmalonic encephalopathy 1 protein" and "per sulfide dioxygenase", is a protein that in humans is encoded by the ETHE1 gene located on chromosome 19.[1] # Structure The human ETHE1 gene consists of 7 exons and encodes for a protein that is approximately 27 kDa in ...
https://www.wikidoc.org/index.php/ETHE1
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EVI5L
EVI5L EVI5L (Ecotropic Viral Integration Site 5-Like) is a protein that in humans is encoded by the EVI5L gene. EVI5L is a member of the Ras superfamily of monomeric guanine nucleotide-binding (G) proteins, and functions as a GTPase-activating protein (GAP) with a broad specificity. Measurement of in vitro Rab-GAP acti...
EVI5L EVI5L (Ecotropic Viral Integration Site 5-Like) is a protein that in humans is encoded by the EVI5L gene.[1] EVI5L is a member of the Ras superfamily of monomeric guanine nucleotide-binding (G) proteins, and functions as a GTPase-activating protein (GAP) with a broad specificity.[2][3] Measurement of in vitro Ra...
https://www.wikidoc.org/index.php/EVI5L
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Echis
Echis Echis is a genus of venomous vipers found in the dry regions of Africa, the Middle East, India and Sri Lanka. These snakes are quick-tempered and strike readily, which, combined with a virulent hemotoxic venom, makes them very dangerous, despite their small size. They also have a characteristic threat display, ru...
Echis Echis is a genus of venomous vipers found in the dry regions of Africa, the Middle East, India and Sri Lanka. These snakes are quick-tempered and strike readily, which, combined with a virulent hemotoxic venom, makes them very dangerous, despite their small size. They also have a characteristic threat display, r...
https://www.wikidoc.org/index.php/Echis
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wikidoc
Edema
Edema Synonyms and keywords: oedema or œdema # Overview Edema (American English), formerly known as dropsy or hydropsy, is the increase of interstitial fluid in any organ — swelling. Generally, the amount of interstitial fluid is in the balance of homeostasis. Increased secretion of fluid into the interstitium or impa...
Edema Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Martin Nino, M.D. [2] Synonyms and keywords: oedema or œdema # Overview Edema (American English), formerly known as dropsy or hydropsy, is the increase of interstitial fluid in any organ — swelling. Generally, the amount of inter...
https://www.wikidoc.org/index.php/Edema
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Elbow
Elbow The elbow-joint is a ginglymus or hinge joint. Three bones form the elbow joint: the humerus of the upper arm, and the paired radius and ulna of the forearm. The bony prominence at the very tip of the elbow is the olecranon process of the ulna. # Movements Two main movements are possible at the elbow: - The hing...
Elbow Template:Infobox Anatomy Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] The elbow-joint is a ginglymus or hinge joint. Three bones form the elbow joint: the humerus of the upper arm, and the paired radius and ulna of the forearm. The bony prominence at the very tip of the elbow is the olecranon process of th...
https://www.wikidoc.org/index.php/Elbow
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Enone
Enone An enone is an unsaturated chemical compound or functional group consisting of a conjugated system of an alkene and a ketone. The simplest enone is methyl vinyl ketone (MVK) or CH2=CHCOCH3. As an example, an enone such as a chalcone can be synthesized in a Knoevenagel condensation. In the Meyer-Schuster rearrang...
Enone An enone is an unsaturated chemical compound or functional group consisting of a conjugated system of an alkene and a ketone. The simplest enone is methyl vinyl ketone (MVK) or CH2=CHCOCH3. As an example, an enone such as a chalcone can be synthesized in a Knoevenagel condensation. In the Meyer-Schuster rearran...
https://www.wikidoc.org/index.php/Enone
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Eosin
Eosin # Overview Eosin is a fluorescent acidic / negative compound that binds to and forms salts with basic, or eosinophilic, compounds containing positive charges (such as proteins that are basic / positive due to the presence of amino acid residues such as Arginine and Lysine) and stains them dark red or pink as a r...
Eosin Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] # Overview Eosin is a fluorescent acidic / negative compound that binds to and forms salts with basic, or eosinophilic, compounds containing positive charges (such as proteins that are basic / positive due to the presence of amino acid residues such as Arginine...
https://www.wikidoc.org/index.php/Eosin
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Ester
Ester # Overview Esters are a class of chemical compounds and functional groups. Esters consist of an inorganic or organic acid in which at least one -OH (hydroxy) group is replaced by an -O-alkyl (alkoxy) group. The most common type of esters are carboxylic acid esters (R1-C(=O)-O-R2), other esters include phosphoric...
Ester Editor-In-Chief: Henry A. Hoff # Overview Esters are a class of chemical compounds and functional groups. Esters consist of an inorganic or organic acid in which at least one -OH (hydroxy) group is replaced by an -O-alkyl (alkoxy) group. The most common type of esters are carboxylic acid esters (R1-C(=O)-O-R2),...
https://www.wikidoc.org/index.php/Ester
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Ether
Ether # Overview Ether is the general name for a class of chemical compounds which contain an ether group — an oxygen atom connected to two (substituted) alkyl or aryl groups — of general formula R – O–R'. A typical example is the solvent and anesthetic diethyl ether, commonly referred to simply as "ether" (ethoxyetha...
Ether Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] # Overview Ether is the general name for a class of chemical compounds which contain an ether group — an oxygen atom connected to two (substituted) alkyl or aryl groups — of general formula R – O–R'.[1] A typical example is the solvent and anesthetic diethyl et...
https://www.wikidoc.org/index.php/Ether
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Etrog
Etrog Etrog, ethrog or esrog are all different pronounciations of the word אֶתְרוֹג, which is the most common Hebrew name for the citron or Citrus Medica. It is one of the four species used in a waving ritual during the Jewish holiday of Sukkot. The other species are the lulav (date palm frond), hadass (myrtle bough), ...
Etrog Etrog, ethrog or esrog are all different pronounciations of the word אֶתְרוֹג, which is the most common Hebrew name for the citron or Citrus Medica. It is one of the four species used in a waving ritual during the Jewish holiday of Sukkot. The other species are the lulav (date palm frond), hadass (myrtle bough),...
https://www.wikidoc.org/index.php/Etrog
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Ezrin
Ezrin Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene. # Structure The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. # Function The cytoplasmic peripheral protein encoded by this gene...
Ezrin Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.[1] # Structure The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. # Function The cytoplasmic peripheral protein encoded by this ...
https://www.wikidoc.org/index.php/Ezrin
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wikidoc
FABP1
FABP1 FABP1 is a human gene coding for the protein product FABP1 (Fatty Acid-Binding Protein 1). It is also frequently known as liver-type fatty acid-binding protein (LFABP). FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endoc...
FABP1 FABP1 is a human gene coding for the protein product FABP1 (Fatty Acid-Binding Protein 1). It is also frequently known as liver-type fatty acid-binding protein (LFABP). FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endo...
https://www.wikidoc.org/index.php/FABP1
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FABP2
FABP2 Fatty acid-binding protein 2 (FABP2) also known as Intestinal-type fatty acid-binding protein (I-FABP) is a protein that in humans is encoded by the FABP2 gene. # Function The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided i...
FABP2 Fatty acid-binding protein 2 (FABP2) also known as Intestinal-type fatty acid-binding protein (I-FABP) is a protein that in humans is encoded by the FABP2 gene.[1] # Function The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divid...
https://www.wikidoc.org/index.php/FABP2
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wikidoc
FABP5
FABP5 Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene. # Function This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conser...
FABP5 Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene.[1][2] # Function This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly...
https://www.wikidoc.org/index.php/FABP5
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FABP7
FABP7 Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene. # Function The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty aci...
FABP7 Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.[1] # Function The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty...
https://www.wikidoc.org/index.php/FABP7
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wikidoc
FADS1
FADS1 Fatty acid desaturase 1 is an enzyme that in humans is encoded by the FADS1 gene. # Function The protein encoded by the FADS1 gene is a member of the fatty acid desaturase (FADS) gene family and desaturates omega-3 and omega-6 polyunsaturated fatty acids at the delta-5 position, catalyzing the final step in the ...
FADS1 Fatty acid desaturase 1 is an enzyme that in humans is encoded by the FADS1 gene.[1] # Function The protein encoded by the FADS1 gene is a member of the fatty acid desaturase (FADS) gene family and desaturates omega-3 and omega-6 polyunsaturated fatty acids at the delta-5 position, catalyzing the final step in ...
https://www.wikidoc.org/index.php/FADS1
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FADS2
FADS2 This article is about the gene, for main associated enzyme see D6D. Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well. Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and...
FADS2 This article is about the gene, for main associated enzyme see D6D. Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[1][2] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delt...
https://www.wikidoc.org/index.php/FADS2
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wikidoc
FAHD1
FAHD1 Fumarylacetoacetate hydrolase domain-containing protein 1, also known as FLJ36880 protein, is an enzyme that in humans is encoded by the FAHD1 gene on chromosome 16. # Structure The FAHD1 gene encodes for a 24-kDa protein that is localized to the mitochondrion and belongs to the fumarylacetoacetate hydrolase fam...
FAHD1 Fumarylacetoacetate hydrolase domain-containing protein 1, also known as FLJ36880 protein, is an enzyme that in humans is encoded by the FAHD1 gene on chromosome 16.[1] # Structure The FAHD1 gene encodes for a 24-kDa protein that is localized to the mitochondrion and belongs to the fumarylacetoacetate hydrolase...
https://www.wikidoc.org/index.php/FAHD1
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FANCA
FANCA Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene. It belongs to the Fanconi anaemia complementation group (FANC) family of genes of which 12 complementation groups are currently recognized and is hypothesised to operate as a pos...
FANCA Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene.[1] It belongs to the Fanconi anaemia complementation group (FANC) family of genes of which 12 complementation groups are currently recognized and is hypothesised to operate as a...
https://www.wikidoc.org/index.php/FANCA
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wikidoc
FANCB
FANCB Fanconi anemia group B protein is a protein that in humans is encoded by the FANCB gene. # Function The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically heterogeneous recessive d...
FANCB Fanconi anemia group B protein is a protein that in humans is encoded by the FANCB gene.[1][2][3] # Function The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically heterogeneous r...
https://www.wikidoc.org/index.php/FANCB
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FANCE
FANCE Fanconi anemia, complementation group E protein is a protein that in humans is encoded by the FANCE gene. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically heterogeneous recess...
FANCE Fanconi anemia, complementation group E protein is a protein that in humans is encoded by the FANCE gene.[1][2][3] The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically heterogene...
https://www.wikidoc.org/index.php/FANCE
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wikidoc
FANCF
FANCF Fanconi anemia group F protein is a protein that in humans is encoded by the FANCF gene. # Interactions FANCF has been shown to interact with Fanconi anemia, complementation group C, FANCG, FANCA and FANCE. # Function FANCF is an adaptor protein that plays a key role in the proper assembly of the FA core comple...
FANCF Fanconi anemia group F protein is a protein that in humans is encoded by the FANCF gene.[1][2] # Interactions FANCF has been shown to interact with Fanconi anemia, complementation group C,[3][4] FANCG,[3][4][5][6] FANCA[3][4][7] and FANCE.[3][8] # Function FANCF is an adaptor protein that plays a key role in t...
https://www.wikidoc.org/index.php/FANCF
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FANCG
FANCG Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene. # Function FANCG, involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid p...
FANCG Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene.[1][2][3] # Function FANCG, involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-am...
https://www.wikidoc.org/index.php/FANCG
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FANCL
FANCL E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene. # Function The clinical phenotype of mutational defects in all Fanconi anemia (FA) complementation groups is similar. This phenotype is characterized by progressive bone marrow failure, cancer proneness and typical birth...
FANCL E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene.[1] # Function The clinical phenotype of mutational defects in all Fanconi anemia (FA) complementation groups is similar. This phenotype is characterized by progressive bone marrow failure, cancer proneness and typical b...
https://www.wikidoc.org/index.php/FANCL
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wikidoc
FANCM
FANCM Fanconi anemia, complementation group M, also known as FANCM is a human gene. # Function The protein encoded by this gene, FANCM displays DNA binding against fork structures and an ATPase activity associated with DNA branch migration. It is believed that FANCM in conjunction with other Fanconi anemia- proteins r...
FANCM Fanconi anemia, complementation group M, also known as FANCM is a human gene.[1][2] # Function The protein encoded by this gene, FANCM displays DNA binding against fork structures[3] and an ATPase activity associated with DNA branch migration. It is believed that FANCM in conjunction with other Fanconi anemia- ...
https://www.wikidoc.org/index.php/FANCM
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wikidoc
FARP2
FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene. # Model organisms Model organisms have been used in the study of FARP2 function. A conditional knockout mouse line, called Farp2tm1a(KOMP)Wtsi was generated as part of the International Knockout Mous...
FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.[1][2][3] # Model organisms Model organisms have been used in the study of FARP2 function. A conditional knockout mouse line, called Farp2tm1a(KOMP)Wtsi[8][9] was generated as part of the Internation...
https://www.wikidoc.org/index.php/FARP2
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wikidoc
FARS2
FARS2 Phenylalanyl-tRNA synthetase, mitochondrial (FARS2) is an enzyme that in humans is encoded by the FARS2 gene. This protein encoded by FARS2 localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene have been associated with combined oxidative phosphorylation defi...
FARS2 Phenylalanyl-tRNA synthetase, mitochondrial (FARS2) is an enzyme that in humans is encoded by the FARS2 gene.[1] This protein encoded by FARS2 localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene have been associated with combined oxidative phosphorylation ...
https://www.wikidoc.org/index.php/FARS2
ea7c49c841bbabd95b9257c72d837a912aae17ed
wikidoc
FATE1
FATE1 Fetal and Adult Testis-Expressed 1, encoded by the FATE1 gene in humans, is a protein identified as a cancer-testis antigen (CTA) in hepatocellular carcinomas and gastric and colon cancers. It is testis-specific in the fetus (aged 6 – 11 weeks). In adults, it is expressed predominantly in the testis and adrenal g...
FATE1 Fetal and Adult Testis-Expressed 1, encoded by the FATE1 gene in humans, is a protein identified as a cancer-testis antigen (CTA) in hepatocellular carcinomas and gastric and colon cancers.[1][2][3] It is testis-specific in the fetus (aged 6 – 11 weeks). In adults, it is expressed predominantly in the testis and...
https://www.wikidoc.org/index.php/FATE1
802e602681f67d9eecdbdcfd66c0dddee0643f9c
wikidoc
FBLN1
FBLN1 FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein. # Function Fibulin-1 is a secreted glycoprotein that is found in association with extracellular matrix structures including fibronectin-containing fibers, elastin-containing fibers and basement membranes. Fibulin-1 binds to a numbe...
FBLN1 FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein.[1][2][3] # Function Fibulin-1 is a secreted glycoprotein that is found in association with extracellular matrix structures including fibronectin-containing fibers, elastin-containing fibers and basement membranes. Fibulin-1 binds ...
https://www.wikidoc.org/index.php/FBLN1
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wikidoc
FBLN2
FBLN2 Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene. This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart,...
FBLN2 Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.[1][2] This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of...
https://www.wikidoc.org/index.php/FBLN2
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wikidoc
FBLN5
FBLN5 Fibulin-5 (also known as DANCE (developmental arteries and neural crest epidermal growth factor (EGF)-like)) is a protein that in humans is encoded by the FBLN5 gene. # Function The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding ...
FBLN5 Fibulin-5 (also known as DANCE (developmental arteries and neural crest epidermal growth factor (EGF)-like)) is a protein that in humans is encoded by the FBLN5 gene.[1][2] # Function The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-b...
https://www.wikidoc.org/index.php/FBLN5
da3592669634892085417d87d1457dd0c24af322
wikidoc
FBXL3
FBXL3 FBXL3 is a gene in humans and mice that encodes the F-box/LRR-repeat protein 3 (FBXL3). FBXL3 is a member of the F-box protein family, which constitutes one of the four subunits in the SCF ubiquitin ligase complex. The FBXL3 protein participates in the negative feedback loop responsible for generating molecular c...
FBXL3 FBXL3 is a gene in humans and mice that encodes the F-box/LRR-repeat protein 3 (FBXL3).[1][2] FBXL3 is a member of the F-box protein family, which constitutes one of the four subunits in the SCF ubiquitin ligase complex.[3] The FBXL3 protein participates in the negative feedback loop responsible for generating m...
https://www.wikidoc.org/index.php/FBXL3
a61d693a5cc4190991a32ca025a9d33c467dc10d
wikidoc
FBXL5
FBXL5 F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called S...
FBXL5 F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.[1][2] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex c...
https://www.wikidoc.org/index.php/FBXL5
46023e47e036479356012465a62eecb5a0a9b0f6
wikidoc
FBXO5
FBXO5 F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene. # Function This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase comple...
FBXO5 F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.[1][2][3] # Function This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein lig...
https://www.wikidoc.org/index.php/FBXO5
cc48133e721db3680d6b140eb836414517876a2b
wikidoc
FBXW7
FBXW7 F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. # Function This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein l...
FBXW7 F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene.[1][2][3] # Function This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin...
https://www.wikidoc.org/index.php/FBXW7
fe063c1bfba22ac92c2a623619ac2b38732aadcb
wikidoc
FCER1
FCER1 The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in the allergy disorder and parasites immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. I...
FCER1 The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in the allergy disorder and parasites immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE.[...
https://www.wikidoc.org/index.php/FCER1
50cbfa5ed2c8cd2fef0eff9d2e3e735932836cf7
wikidoc
FGF10
FGF10 Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene. # Function The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processe...
FGF10 Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.[1][2] # Function The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological p...
https://www.wikidoc.org/index.php/FGF10
dab0d46d590cda1516877d2738e31bc59721ee9a
wikidoc
FGF16
FGF16 Fibroblast growth factor 16 is a protein which in humans is encoded by the FGF16 gene. # Function The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological process...
FGF16 Fibroblast growth factor 16 is a protein which in humans is encoded by the FGF16 gene.[1][2] # Function The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological ...
https://www.wikidoc.org/index.php/FGF16
934c0951e5d676987641a86a362569e985f73fab
wikidoc
FGF19
FGF19 Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders. # ...
FGF19 Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene.[1] It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders....
https://www.wikidoc.org/index.php/FGF19
6d8012e656b8864f7884cac7aaabe08203fb5380
wikidoc
FGF21
FGF21 Fibroblast growth factor 21 is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19. FGF21 is the primary endogenous agonist of the FG...
FGF21 Fibroblast growth factor 21 is a protein that in mammals is encoded by the FGF21 gene.[1][1][2] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19. FGF21 is the primary endogenous agonist...
https://www.wikidoc.org/index.php/FGF21
7645d1873d1864bd186a8182de79a0ea0ffc2163
wikidoc
FHAD1
FHAD1 Forkhead-associated domain containing protein 1 (FHAD1) is a protein encoded by the FHAD1 gene. As the name suggests, it has a forkhead-associated domain and an extensive coiled coil structure. It is predicted to have a function related to DNA transcription. It is localized to the nucleus and has a nuclear locali...
FHAD1 Forkhead-associated domain containing protein 1 (FHAD1) is a protein encoded by the FHAD1 gene. As the name suggests, it has a forkhead-associated domain and an extensive coiled coil structure. It is predicted to have a function related to DNA transcription. It is localized to the nucleus and has a nuclear local...
https://www.wikidoc.org/index.php/FHAD1
9ad490555c4ff0b6ecf2c8a5b44db7ec0e680e6e
wikidoc
FIGLA
FIGLA Folliculogenesis-specific basic helix-loop-helix, also known as factor in the germline alpha (FIGalpha) or transcription factor FIGa, is a protein that in humans is encoded by the FIGLA gene. The FIGLA gene is a germ cell-specific transcription factor preferentially expressed in oocytes that can be found on human...
FIGLA Folliculogenesis-specific basic helix-loop-helix, also known as factor in the germline alpha (FIGalpha) or transcription factor FIGa, is a protein that in humans is encoded by the FIGLA gene.[1][2] The FIGLA gene is a germ cell-specific transcription factor preferentially expressed in oocytes that can be found o...
https://www.wikidoc.org/index.php/FIGLA
95a610a9cf9e073e3e55fab2b0b6eaf11c22844c
wikidoc
FITM2
FITM2 Fat storage-inducing transmembrane protein 2 is a protein that in humans is encoded by the FITM2 gene. It plays a role in fat storage. Its location is 20q13.12 and it contains 2 exons. It is also a member of the FIT protein family that has been conserved throughout evolution. Conserved from Saccharomyces cerevisi...
FITM2 Fat storage-inducing transmembrane protein 2 is a protein that in humans is encoded by the FITM2 gene. It plays a role in fat storage. Its location is 20q13.12 and it contains 2 exons.[1] It is also a member of the FIT protein family that has been conserved throughout evolution. Conserved from Saccharomyces cere...
https://www.wikidoc.org/index.php/FITM2
823465152525382d402ec092c17e55d3d7646935
wikidoc
FKBP3
FKBP3 FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene. # Function The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis...
FKBP3 FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene.[1][2][3] # Function The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protei...
https://www.wikidoc.org/index.php/FKBP3
862d8d96d9dcba050c24be91b0db115da0b10b5c
wikidoc
FKBP5
FKBP5 FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene. # Function The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This e...
FKBP5 FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene.[1] # Function The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Th...
https://www.wikidoc.org/index.php/FKBP5
6b8149a57122d349c2f3c6b22b83cf6c53ea656d
wikidoc
FKBP6
FKBP6 FK506 binding protein 6, also known as FKBP6, is a human gene. The encoded protein shows structural homology to FKBP immunophilins, which bind to the immunosuppressants FK506 and rapamycin. FKBP6 is essential for homologous chromosome pairing in meiosis during spermatogenesis. Targeted inactivation of FKBP6 in ...
FKBP6 FK506 binding protein 6, also known as FKBP6, is a human gene. The encoded protein shows structural homology to FKBP immunophilins, which bind to the immunosuppressants FK506 and rapamycin. FKBP6 is essential for homologous chromosome pairing in meiosis during spermatogenesis. Targeted inactivation of FKBP6 in...
https://www.wikidoc.org/index.php/FKBP6
02097e86185437703c3ad8bfee8706cec05bcb5c
wikidoc
FKBPL
FKBPL FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene. # Function FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thoug...
FKBPL FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.[1] # Function FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is t...
https://www.wikidoc.org/index.php/FKBPL
9f6cd9f9037d8fce8690e12a169e724925092b01
wikidoc
FLOT2
FLOT2 Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene. Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transducti...
FLOT2 Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene.[1][2] Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal tra...
https://www.wikidoc.org/index.php/FLOT2
70cee9c7612c8384c2f5bdd26d3ff25518761614
wikidoc
FMNL1
FMNL1 Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene. This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been dete...
FMNL1 Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene.[1][2] This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not be...
https://www.wikidoc.org/index.php/FMNL1
f8f7483f926cde690184a59b25159b2d40419d93
wikidoc
FMNL2
FMNL2 Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene. # Expression Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described. The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2) is regulated throu...
FMNL2 Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[1][2] # Expression Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[1] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[3]) is re...
https://www.wikidoc.org/index.php/FMNL2
14efe23fd56a2a0007e44d543c5864205d7eba7f
wikidoc
FNAEG
FNAEG The Fichier National Automatisé des Empreintes Génétiques (Automated National File of Genetic Prints) is the French national DNA database, used by both the national police force and local gendarmerie. # Origins of FNAEG In 1996 Alain Marsaud, the former chief of the French central antiterrorist service, proposed...
FNAEG The Fichier National Automatisé des Empreintes Génétiques (Automated National File of Genetic Prints) is the French national DNA database, used by both the national police force and local gendarmerie. # Origins of FNAEG In 1996 Alain Marsaud, the former chief of the French central antiterrorist service, propose...
https://www.wikidoc.org/index.php/FNAEG
1a52cf16ce1d00777d189ecbf4c7bd6f4295b2f3
wikidoc
FNDC5
FNDC5 Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris. Fibronectin domain-containing protein 5 is a membrane protein comprising a short cytoplasmic domain, a tra...
FNDC5 Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.[1] Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris.[2] Fibronectin domain-containing protein 5 is a membrane protein comprising a short cytoplasmic domain...
https://www.wikidoc.org/index.php/FNDC5