question stringlengths 1 6.54k | choices listlengths 4 4 | answer stringclasses 4 values | rationale stringlengths 0 22.5k ⌀ | split stringclasses 1 value | dataset stringclasses 6 values | subject stringclasses 1 value |
|---|---|---|---|---|---|---|
The most common clinical manifestation of Multiple Sclerosis is | [
"Intemuclear Ophthalmoplegia",
"Ataxia",
"Optic Neuritis",
"Diplopia"
] | C | (C) Optic Neuritis INITIAL SYMPTOMS OF MULTIPLE SCLEROSISSymptomPercent of CasesSymptomPercent of Cases* Sensory loss37* Lhermitte3* Optic neuritis36* Pain3* Weakness35* Dementia2* Paresthesias24* Visual loss2* Diplopia15* Facial palsy1* Ataxia11* Impotence1* Vertigo6* Myokymia1* Paroxysmal attacks4* Epilepsy1* Bladder4* Falling1# Optic neuritis is the commonest presenting feature of multiple sclerosis out of the given choices. It is roughly seen in 36% of cases.> Sensory loss may be the initial symptom in 37% cases.> Optic neuritis generally presents as decreased acuity, dimness or colour desaturation in central field of vision.> Afferent pupillary response may be detected.> Internuclear (not intranuclear) ophthalmoplegia consists of slow adduction of one eye with nystagmus in the abducting eye.> Impaired adduction is due to lesion in medial longitudinal fasciculus.> Bilateral internuclear ophthalmoplegia is highly suggestive of multiple sclerosis. Lhermitte's symptom (sensation of electric shock on flexion of neck) is seen in multiple sclerosis. Seizure and aphasia are uncommon in multiple sclerosis. Afferent pupillary defect is seen in multiple sclerosis. There is abnormality in visual evoked potential. MRI helps in confirming the diagnosis. | train | med_mcqa | null |
Wof is a disease modifying antirheumatic drug whose active metabolite inhibits the enzyme dihydro-orotate dehydrogenase | [
"Sulfasalazine",
"Nimesulide",
"Leflunomide",
"Colchicine"
] | C | Leflunomide Mech of action:- This immunomodulator inhibits proliferation of stimulated lymphocytes in patients with active RA. Ahritic symptoms are suppressed and radiological progression of disease is retarded. Leflunomide is rapidly conveed in the body to an active metabolite which inhibits dihydro-orotate dehydrogenase and pyrimidine synthesis in actively dividing cells. Antibody production by B-cells may be depressed. The active metabolite has a long t 1/2 of 2-3 weeks. Adverse effects:- Include diarrhoea, headache, nausea, rashes, loss of hair, thrombocytopenia, leucopenia, increased chances of chest infection and raised hepatic transaminases. It is not to be used in children and pregnant/ lactating women. Ref:- kd tripathi; pg num:-212 | train | med_mcqa | null |
A 35 years old female came with multiple inverted sauce shaped ulcer over the body,sensations was near normal . SSS was positive and lepromin test was negative.How do you treat this patient? | [
"T.Rifampicin 600 mg and T.Clofazimine 300 mg once in month and T.Clofazimine 50 mg daily + T. Dapsone 100 mg daily for 12 months",
"T.Rifampicin 600 mg and T.Clofazimine 300 mg once in month and T.Clofazimine 100 mg daily + T. Dapsone 1000 mg daily for 12 months",
"T.Rifampicin 600 mg and T.Clofazimine 300 mg ... | A | Multiple skin lesions,normal sensation indicating no nerve compresion,SSS :positive suggests of multibacillary leprosy | train | med_mcqa | null |
. All of the following statements about the use of spironolactone in CHF are true except | [
"It should be administered in low doses to prevent hyperkalemial",
"It affords prognostic benefit in severe hea failure over and above that afforded by ACE inhibitors",
"It helps to overcome the refractoriness to thiazides",
"It affords rapid symptomatic relief in CHF patients"
] | D | (Ref KDT 6/e p507) Loop diuretics are used to provide rapid symptomatic relief whereas aldosterone antagonists decrease the moality by reversing myocardial remodeling | train | med_mcqa | null |
Finkelstein's test is positive in: | [
"Perilunate dislocation",
"Scaphoid fracture",
"Dislocation of shoulder",
"Dequervain's tenosynovitis"
] | D | Ans. D. Dequervain's tenosynovitisDequervain's disease which is stenosing tenosynovitis of the first extensor compartment of the forearm at the level of the wrist. The physician grasps the patient's thumb and fingers holding the forearm with the other hand then quickly deviates the wrist to the ulnar side, this causes severe pain over the styloid process of the Radius. This is Finkelstein's test. | train | med_mcqa | null |
Ceruloplasmin binds | [
"Iron",
"Copper",
"Zinc",
"Manganese"
] | B | Ceruloplasmin -Transpo of copper(table no32-6).(REF: GANONG'S REVIEW OF MEDICAL PHYSIOLOGY 23rd EDITION page no.532) | train | med_mcqa | null |
Gemcitabine is effective in - | [
"Head and neck cancers",
"Pancreatic cancer",
"Small-cell lung cancer",
"Soft tissue sarcoma"
] | B | Ans. is 'b' i.e., Pancreatic cancer o Gemcitabine is the DOC for pancreatic carcinoma. | train | med_mcqa | null |
Post moem luminescence is associated with ingestion of which of the following? | [
"Dhatura",
"Mercury",
"Armillaria",
"Oleander"
] | C | Luminescence of dead body may occur due to contamination of bacteria like photobacterium, fischeri, luminescent fungi, armillaria mellea etc. | train | med_mcqa | null |
True about thromboxane A2:
A) Formed by platelets
B) Formed from PGG2/PGH2
C) Prothrombogenic
D) Vasoconstricter
E) Vasodilator | [
"ABC",
"ABCDE",
"ABCD",
"ACB"
] | C | null | train | med_mcqa | null |
Selegiline is | [
"Dopa decarboxylase inhibitor",
"MAO-B inhibitor",
"COMT inhibitor",
"MAO-A inhibitor"
] | B | (B) MAO-B inhibitor # Selegiline is a MAO-B inhibitor.> MAO exist in forms MAO-A & MAO-B.> MAO-A predominates in peripheral adrenergic structures & intestinal mucosa.> MAO-B predominates in brain & Blood platelets. Selegline, along c- levodopa, prolongs its action, & wearing-off effect.> Based on the theory that oxidation of DA or toxin MPTP in the striatum by MAO to free radicals is cause for parkinsonism early therapy c- selegiline night delay progression of disorders.> Non selective MAO inhibitors include: Phenelzinec/lsocarboxazide/Tranylcypromine.> Selective MAO-A are: Clorgiline/ Moclobemidee> Selective MAO-B are: Selegiline (Deprenyl), Rasagline, Periphery, BLood brain barrier | train | med_mcqa | null |
Local anaesthetic with prolonged action | [
"Procaine",
"Cocaine",
"Lidocaine",
"Dibucaine"
] | D | Dibucaine is the longest acting local anaestheticChlorprocaine is the shoest acting local anaestheticDecreasing order of duration: Dibucaine >Bupivacine= Tetracaine = Ropivacaine=Etidocaine > Prilocaine = lignocaine =Mepivacaine = Cocaine >Procaine >Chloprocaine(Refer: stoelting's pharmacology and physiology in anaesthetic practice, 5th edition, pg no.290,304) | train | med_mcqa | null |
Infectivity of an organism is measured by | [
"Incidence rate",
"Prevalence rate",
"Secondary attack rate",
"Case fatality rate"
] | A | Infectivity of an organism is measured by incidence rate Incidence rate: It is the number of new cases occuring in a defined population during a specified period of time Prevalence rate: It is the number of new and old cases existing in a population during a specified period of time Case fatality rate: It is the ratio of total number of deaths due to a paicular disease to total number of cases due to same disease Secondary attack rate: It is defined as the number of exposed person developing the disease within the range of the incubation period following exposure to a primary case Ref : Park&;s Textbook of preventive and social medicine; 24th edition; Pg no 60 | train | med_mcqa | null |
Proposed guideline values for Radioactivity in Drinking water is | [
"Gross a activity 1.0 Bq/L and Gross b activity 10.0 Bq/L",
"Gross a activity 1.0 Bq/L and Gross b activity 0.1 Bq/L",
"Gross a activity 0.1 Bq/L and Gross b activity 1.0 Bq/L",
"Gross a activity 10 Bq/L and Gross b activity 1.0 Bq/L"
] | C | Key guideline aspects of WHO recommended drinking water quality: –
Colour < 15 true colour units (TCU)
Turbidity < 5 nephlometric turbidity units (NTU)
pH: 6.5 – 8.5
Total dissolved solids (TDS) < 600 mg/litre
Zero pathogenic microorganisms
Zero infectious viruses
Absence of pathogenic protozoa and infective stages of helminthes
Fluorine < 1.5 ppm (0.5 – 0.8 ppm: Optimum level)
Nitrates < 50 mg/litre
Nitrites < 3 mg/litre
Gross alpha radiological activity < 0.5 Bq/litre (New Guideline — WhO)
Gross beta radiological activity < 1.0 Bq/litre (New Guideline — WhO). | train | med_mcqa | null |
Tetanus prophylaxis for contaminated wound in a paially immune person is | [
"Toxoid x 1, antibiotics",
"Toxoid x 2 , TIG",
"Toxoid x 3 , TIG, antibiotics",
"Toxoid x 1, TIG, antibiotics"
] | D | . | train | med_mcqa | null |
Maximum accepted contamination rate for a blood culture is? | [
"1%",
"4%",
"3%",
"6.20%"
] | C | Ans. is 'c' i.e., 3% style="font-size: 1.04761904761905em; font-family: Times New Roman, Times, serif">"According to the Clinical and Laboratory Standards Institute guidelines, the maximum acceptable percentage of contaminated blood culture in any healthcare facility is 3%" - "The acceptable blood contamination rate benchmark is 2-3%y with rates ranging from 1% to 9%."- style="font-size: 1.04761904761905em; font-family: Times New Roman, Times, serif">"While target rates for contamination have been set at 2 to 3%, actual rates seem to vary widely between institutions, from as little as 0.6% to over 6%" -Blood culture contaminationoBlood culture remains an important diagnostic tool to identify the causative agent of bloodstream infection (BSI) as well as to direct the definitive therapy. Blood culture contamination has been a common problem for decades which continues to be the cause of a diagnostic confusion and frustration for the clinicians and laboratory personnel alike. Prevalence of pathogens causing BSI, and their antibiotic susceptibility pattern do help to develop local antimicrobial guidelines.oOn receiving positive blood culture result, the clinicians should establish whether the isolated organism represents a clinically significant infection or a false positive result of no clinical significance. False positive blood cultures are associated with increased length of hospital stay, inappropriate initiation of antibiotics, additional laboratory testing and increased healthcare cost.oResearch has found that it is virtually impossible to have a contamination free rate (0%) in the modern clinical settings. However, the contamination rate between microbiology laboratories varies, from 0.96%-6%. According to the Clinical and Laboratory Standards Institute guidelines, the maximum acceptable percentage of contaminated blood culture in any healthcare facility is 3%,oFactors associated with blood culture contamination include, but are not limited to, poor technique and procedure used to collect blood, lack of dedicated phlebotomists, improper skin antisepsis. | train | med_mcqa | null |
Connecting sinus between cavernous sinus and transverse sinus | [
"Superior petrosal sinus.",
"Inferior petrosal sinus.",
"Horizontal sinus",
"Horizontal sinus Vertical sinus."
] | A | null | train | med_mcqa | null |
All of the following are not true with respect to erythema multiforme except ? | [
"Targetoid lesions are seen",
"Steroids are the drug of choice",
"Koebner's phenomenon is seen",
"Most commonly due to leukaemia"
] | C | Erythema multiforme Known cause MC- Viral infection, commonly Herpes simplex > Mycoplasma Drugs : antiepileptic, antibiotics,anti gout, anti retroviral etc. Other : (antimalarial >Leukemia) Unknown cause : Idiopathic C/f: Target/ iris /bulls eye lesion are seener CAUTION : ALL ARE NOT TRUE ; MEANS ALL ARE FALSE EXCEPT i.e TRUE STATEMENT IS !!! | train | med_mcqa | null |
ICDS include children upto age of_______ years | [
"3",
"5",
"6",
"14"
] | C | Ans. (c) 6Ref: K. Park 23rd ed. / 590,661, 21st ed. /545, 611* ICDS is Integrated Child Development Services which was started in 1975.* This program include a strong supplementary nutrition component in form of Vitamin A prophylaxis and iron & folic acid distribution.* The workers at village level who deliver the services are called Anganwadi workers.Beneficiaries of ICDS* Preschool children below 6 years.* Adolescent girls 11 to 18 years old.* Pregnant and lactating mothers. | train | med_mcqa | null |
Jarisch Herxheimer reaction is commonly seen in- | [
"Early syphilis",
"Late congenital syphilis",
"Latent syphilis",
"Syphilis of cardiovascular system"
] | A | Jarisch herxheimer reaction acute self limiting febrile reaction that follow antibiotic therapy for syphilis develops after few hrs after initiation of treatment avg-6-7 hrs common in : early syphilis, secondary syphilis subsides in 12-48hrs clinical features: flu like symptoms, myalgia, ahralgias, headache,fever and hypotension lab: elevated neutrophils, and raised esr treatment: rest, asprin prevention : prednisone exercises 5mg aid 2 days prior to Rex, chlorphenaramine maleate prior to penicillin injection iadvl textbook of dermatology page 1836 | train | med_mcqa | null |
Blood in splanchnic area during exercise is decreased due to: | [
"Venoconstriction with decreased blood flow",
"Venodilation with decreased blood flow",
"Venodilation with increased blood flow",
"Venodilation with normal blood flow"
] | A | During exercise venoconstriction in splanchnic vessels dive the blood from splanchnic to skeletal muscle | train | med_mcqa | null |
A 22 year old lady died. The postmoum appearance that will indicate that she has had delivered a child are all, except : | [
"Walls of uterus are convex from inside.",
"Cervix is irregular and external os is patulous",
"Body of uterus is twice the length of cervix.",
"Uterus is bulky, large and heavy than nullipara"
] | A | A i.e. Walls of uterus are convex from inside Walls are concave from inside forming a wide & rounded uterine cavity in parous uterus; while the walls of nulliparous uterus are convex on inner side.Q | train | med_mcqa | null |
All of the following muscles are supplied pharyngeal plexus except | [
"Palatoglossus",
"Salpingopharyngeus",
"Stylopharyngeus",
"Cricopharyngeus"
] | C | Ninth nerve (glossopharyngeal) is the nerve of third branchial arch, and supplies, the stylopharyngeus. Ref: BD Chaurasia's HUMAN ANATOMY, Volume 3,fouh edition. | train | med_mcqa | null |
Fascia of Waldeyer&;s is seen in? | [
"Between prostate and rectum",
"Between rectum and sacrum",
"Between rectum and pouch of douglas",
"Between bladder and vas"
] | B | The fascia of Waldeyer is a connective tissue by which the rectum( ampulla) is attached to the sacrum and coccyx.Fascia of Denonvilliers lies between the prostate and the ampulla of the rectum.Reference: Textbook of anatomy, Abdomen and lower limb, Vishram Singh, 2nd edition, page no.281 | train | med_mcqa | null |
Erythropoetin in fetus is secreted by? | [
"Liver",
"Marrow",
"Spleen",
"Kidney"
] | A | Sources of erythropoietin: Fetus: Liver Adult: Interstitial cells in peritubular capillary bed of kidneys (85%). Perivenous hepatocytes in the liver (15%). Brain (protective effect against excitotoxic damage triggered by hypoxia). | train | med_mcqa | null |
Most common cause of acute superior mesenteric aerial obstruction is: March 2012 | [
"Embolism",
"Thrombosis",
"Non occlusive ischemia",
"Atherosclerosis"
] | A | Ans: A i.e. Embolism Superior mesenteric aerial obstruction An embolus from the hea or aoa to the superior mesenteric aery is responsible for 40-50% of cases of acute small bowel ischemia Thrombosis of underlying atheromatous disease for approximately 25 % and non-occlusive ischemia due to hypotension complicating myocardial infarction, hea failure, arrhythmias or sudden blood loss for approximately 25% of cases of acute small bowel ischemia Chronic mesenteric ischemia results from atherosclerotic stenosis affecting at least two of the celiac axis, superior mesenteric and inferior mesenteric aeries | train | med_mcqa | null |
Cooley's anemia is other name of? | [
"Beta thalassemia major",
"Beta thalassemia minor",
"Aplastic anemia",
"Pernicious anemia"
] | A | null | train | med_mcqa | null |
Which gas is used for Retinal insufflations (Tamponade of retina) ? | [
"SF6 sulfur hexafluoride",
"S3F8",
"S2F6",
"S4FI0"
] | A | Ref: Kanski Clinical Ophthalmology 6th edition; pg no. 727 - 728; Modem Ophthalmology 3rd edition , LC.Dutta, page no 1753 - 1755Explanation:Indication for Tamponades1. To achieve the retinal flattening by replacing the vitreous2. To drain the subretinal fluid3. To provide the internal tamponade of retinal breaks during the postoperative periodTypes:Expanding gases (See the following table /Indication: Superior retinal breaks (Gas will be floating)Post operative: Patient must maintain a particular head position to prevent pupillary block glaucoma & to give the appropriately directed buoyancy effect. SILICONE OIL: Low specific gravity Acts as tamponade, prevents migration of proliferative cells & biochemical mediator like VEGF within the vitreous cavity and provides hemostasis during surgeryComplication:Emulsification - Inverse hypopyon (the emulsified silicone oil is called hyperleon),Cataract,GlaucomaPERFLUOROCARBON LIQUIDS:High specific gravity - it sinksUses: Displaces the subretinal fluid, unfolds the flapduring surgeries. Hence is is also called as THIRDHANDEg. Perfluorobutylamine, perfluoronoctane, peril uorodec ale n | train | med_mcqa | null |
Carbonic anhydrase is which type of enzyme ? | [
"Coenzyme",
"Metalloenzyme",
"Serine protease",
"Endopeptidase"
] | B | Ans. is 'b' i.e., Metalloenzyme The active site of carbonic anhydrase contains a zinc ion, they are therefore classified as metalloenzymes. | train | med_mcqa | null |
Ratio of ventilation to cardiac compression in adult CPR with two rescuers is: | [
"1:15",
"2:30",
"30:02:00",
"2:10"
] | B | During cardiopulmonary resuscitation of adults,the ratio of chest compression to rescue breaths is 30:2 irrespective of the number of rescuers. High-quality CPRinvolves adequatechest compressions to a depth of at least 5 cm in adults. In infants and children, the ratio is 30:2 for a single rescuer and 15:2 if 2 or more rescuers are present. NOTE THAT IN QUESTION: VENTILATION : COMPRESSION is asked so.. , ratio will be 2:30 | train | med_mcqa | null |
In random sampling, the chance of being picked up is - | [
"Same and known",
"Not same and not known",
"Same and not known",
"Not same but known"
] | A | null | train | med_mcqa | null |
Flexion of MCP joint and extension of IP joints is the major action of ? | [
"Palmar interossei",
"Dorsal interossei",
"Lumbricals",
"FDS"
] | C | Ans. is 'c' i.e., LumbricalsAmongs the given options three muscles cause flexion of MCP joint and extension of IP joint.LumbricalsPalmar interosseiDorsal interosseiBut these movements are mainly produced by lumbricals. Palmar and dorsal interossei assist the lumbricals for these movements.Their major action is :?Palmar interossei -4 Adduction of fingersDorsal interossei - Abduction of fingers | train | med_mcqa | null |
Which of the following is not an absolute contraindication for thrombolytic therapy in acute ST segment elevation myocardial infarction? | [
"Significant closed head injury",
"Symptoms suggestive of aoic dissection",
"Presence of metastatic intracranial malignancy",
"Pregnancy"
] | D | Answer- D. PregnancyPregnancy is a relative contraindication for thrombolytic therapy in acute ST segment elevation myocardial infarction and not an absolute contraindication.Historv of any intracranial hemorrhagicHistory of ischemicl stroke within the preceriing thrse months, with the impoant exception of acute ischemic storke seen within three hours, which may be treated with thrombolytic therapy.Presence of a cerebral vascular malformation or a primary or metastatic intracranial malignancy.Symptoms or signs suggestive of an aoic dessection-A bleeding diathesis or active bleeding, with the exception of menses. thrombolytic therapy may increase the risk of moderate bleeding, which is offset by the benefits of thrombolysis. | train | med_mcqa | null |
A child is presenting with vomiting and abdominal pain after 5 hours of eating some food. The most likely causative organism | [
"Bacillus cereus",
"C. perfringens",
"Cl. Botulinum",
"V. cholerae"
] | A | → Food poisoning presenting within 6 hours is seen:
Staph aureus and
B. cereus.
→ Cl. Botulinum causes constipation (not diarrhea) and the incubation period is about 18-24 hours.
→ V. cholerare has incubation period > 16 hours. | train | med_mcqa | null |
Black water fever is a special manifestation of malaria caused by; | [
"P. falciparum",
"P. malariae",
"P. ovale",
"P. vivax"
] | A | Ans. A. P. falciparumBlackwater fever (BWF) is a severe clinical syndrome, characterized by intravascular hemolysis, hemoglobinuria (with passage of black urine), and acute renal failure caused by a variety of factors in patients with P. falciparum infestation. | train | med_mcqa | null |
The scientist who discovered the transmission of malaria by anopheline mosquito - | [
"Laveran",
"Paul muller",
"Ronal Ross",
"Pampana"
] | C | Discovery Malarial parasite-Charles Laveran Life cycle-A.Bignami,B.Grassi, G.Bastianelli Anopheles species are vectors-Ronald Ross Culture malarial parasite-Trager and Jensen (refer pgno:54 baveja 3 rd edition ) | train | med_mcqa | null |
Which of the following is not associated with Down's syndrome? | [
"Trisomy 2l",
"Mosaic 21",
"Translocation (14;21)(q10;q10),+21",
"Deletion of 2l"
] | D | TRISOMY 21: DOWN SYNDROME Incidence: 1 in 700 bihs Karyotypes: Trisomy 21 type: 47,XX, +21 Translocation type: 46,XX,der(14;21)(q10;q10),+21 Mosaic type: 46,XX/47,XX, +21 (Robbins Basic Pathology, 9 th edition. page : 238).. | train | med_mcqa | null |
Vallecula sign is seen in | [
"TB laryngitis",
"Vocal nodule",
"Inveed papilloma",
"Acute epiglottitis"
] | D | Depressing the tongue with a tongue depressor may show red and swollen epiglottis. Indirect laryngoscopy may show oedema and congestion of supraglottic structure. This examination is avoided for fear of precipitating complete obstruction. It is better done in the operation theatre where facilities for intubation are available. Ref: PL Dhingra 7th edition of Ear, Nose and Throat; Pg no 327 | train | med_mcqa | null |
Paranoid psychosis with cocaine is due to: | [
"Tolerance",
"Withdrawal",
"Reverse tolerance",
"Intoxication"
] | D | The occurrence of the psychotic symptoms depends on the dose, the duration of use, and the individual user's sensitivity to the substance. Paranoid delusions are the most frequent psychotic symptoms. Paranoid delusions and hallucinations can occur in up to 50 percent of all persons who use cocaine. Ref: Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical ... By Benjamin J. Sadock, Virginia A. Sadock, 2007, Page 426 | train | med_mcqa | null |
Paralysis of which of the following muscle causes froment's sign? | [
"Opponen's pollicis",
"Abductor pollicis",
"Adductor pollicis",
"Adductor hallucis longus"
] | C | Pen test - Median NerveCard test - Ulnar Nerve Egawas test - Ulnar Nerve Froment's sign - Ulnar N. | train | med_mcqa | null |
Breast Ca good prognostic markers are :a) ER +veb) Progesterone (receptors) +vec) HER- 2/neu (receptors) +ved) CD44 receptor +vee) p53 gene +ve | [
"ac",
"a",
"ab",
"bc"
] | C | null | train | med_mcqa | null |
Which of the following statements best describes the sulcus limitans? | [
"It is found in the interpeduncular fossa",
"It is located between the alar and basal plates",
"It seperates the medulla from the pons",
"It seperates the hypothalamus from the thalamus"
] | B | The sulcus limitans seperates the sensory alar from the motor basal plates. It is found in the developing spinal cord and on the surface of the adult rhomboid fossa of the fouh ventricle. The bulbopontine sulcus (inferior pontine sulcus) seperates the medulla from the pons. The hypothalamic sulcus seperates the thalamus from the hypothalamus. The rhinal sulcus seperates the neocoex from the allocoex. Ref: Lagman's Embryology 14th edition Pgno: 336 | train | med_mcqa | null |
Proteins in nucleosome are made up of - | [
"Histidine",
"Asparagine",
"Aspartate",
"Glutamate"
] | A | Ans. is 'a' i.e., Histidine* Histones are positively charged by virtue of their composition. They are made up of positively charged or basic aminoacids - Histidine and Arginine* Human chromosome when fully extended will measure a few metres long* Such a long chromosome is packed inside a nucleus of few microns in diameter* This is made possible by histones* Histones are basic proteins - in the sense that they are positively charged. They are made up of lysine and arginine (basic aminoacids)* DNA is negatively charged* So there is an electrostatic attraction between positively charged histones and negatively charged DNA and a segment of double stranded DNA(dsDNA) gets wrapped around histone. This gives the first level of compactness. Hence DNA is amphipathic, i.e., it contains both polar and non polar regions.* There are five types of histones. HI, H2A, H2B, H3. H4.* Of these all except HI, the remaining four form dimers to form a histone octamer. This histone octamer sits in the centre and that is surrounded by a segment of dsDNA of length approx. 146 bp (in a left handed supercoiling). This string on bead appearance is called as nucleosome (FIG).* Several such nucleosomes exist, which are connected by a linker fragment. (Imagine you having a string on which you have placed multiple beads at various places and you have allowed the string to wind around the beads) HI histone is found in the linker fragment. | train | med_mcqa | null |
Which of the following blood gas results is most likely in a patient with hyperventilation caused by anxiety? | [
"increased PCO2",
"decreased PO2",
"decreased pH",
"decreased PCO2"
] | D | The behavioral respiratory control system of the brain drives the hyperventilation, which leads to decreased PCO2 and increased pH. If alkalemia is present with the hypocarbia, symptoms can be quite significant. They include dizziness, visual impairment, syncope, and seizures secondary to cerebral vasoconstriction; paresthesia's, carpopedal spasm, and tetany (secondary to decreased free serum calcium); muscle weakness (secondary to hypophosphatemia); and cardiac arrhythmias (secondary to alkalemia). | train | med_mcqa | null |
"RHIME" is: | [
"A form of verbal autopsy",
"A mode of impaing non formal education",
"A method of behaviour therapy",
"A new hormonal contraceptive"
] | A | RHIME is Representative, Re-sampled, Routine Household Interview of Moality with Medical Evaluation. Under the Sample Registration Surveys since 2000, RHIME has been used as an enhanced form of verbal autopsy for categorization of causes of death especially with reference to maternal moality. Ref: Park, 21st Edition, Page 516. | train | med_mcqa | null |
Labyrinthine aery is a branch of: | [
"Posterior inferior cerebellar aery",
"Veebral aery",
"Posterior cerebral aery",
"Anterior inferior cerebellar aery"
] | D | The labyrinthine aery (auditory aery, internal auditory aery), a long slender branch of the anterior inferior cerebellar aery (85%-100% cases) or basilar aery ( Ref: Moon D.A., Foreman K.B., Albeine K.H. (2011). Chapter 19. Ear. In D.A. Moon, K.B. Foreman, K.H. Albeine (Eds), The Big Picture: Gross Anatomy. | train | med_mcqa | null |
Empirical treatment for meningococcal meningitis is: | [
"Ceftriaxone",
"Cefotetan",
"Gentamicin",
"Cefoxitin"
] | A | Ans. (A) Ceftriaxone(Ref: Harrison 19/e p767)Drug of choice for treatment of meningococcal meningitis is Penicillin G. But for empirical treatment we need to cover other likely organisms too. So, ceftriaxone is preferred that will also cover H. influenzae. Vancomycin is usually added to cover other organisms also. | train | med_mcqa | null |
Myoglobin bind with: | [
"1 mol of oxygen per mol",
"2 mol of oxygen per mol",
"3 mol of oxygen per mol",
"4 mol of oxygen per mol"
] | A | Myoglobin is specialized for sustained muscular contraction. It has only one heme group and does not show Bohr effect | train | med_mcqa | null |
Stensons duct of parotid opens opposite to | [
"Upper second premolar",
"Lower second premolar",
"Lower second molar",
"Upper second molar"
] | D | null | train | med_mcqa | null |
Necrotizing Ulcerative Gingivitis has been demonstrated to be | [
"Communicable but not transmissible",
"Both communicable and transmissible",
"Transmissible but not communicable",
"Neither transmissible nor communicable"
] | C | null | train | med_mcqa | null |
All are resected in whipples operation except - | [
"Duodenum",
"Head of pancreas",
"Portal vein",
"Common bile duct"
] | C | Whipples operation (Pancreaticoduodenectomy)
is the most commonly performed operation for carcinoma of head of pancreas.
It includes resection of:
distal stomach
gall bladder
duodenum
proximal jejunum
CBD
regional lymphatics
head of pancreas
Restoration of gastrointestinal continuity requires
pancreaticojejunostomy
choledochojejunostomy &
gastrojejunostomy | train | med_mcqa | null |
Real Time PCR is used for: | [
"Multiplication of RNA",
"Multiplication of specific segments of DNA",
"Multiplication of Proteins",
"To know how much amplification of DNA has occurred"
] | D | Ans. (d) To know how much amplification of DNA has occured P"F 1,m,etz. 25/e 714, 27/e, p 124; Greenwood 18/e 79 Real Time. PCR It is the molecular detection technique that discriminates real time amplification from conventional PCR assays. The real-time polymerase chain reaction (PCR) uses fluorescent repoer molecules to monitor the production of amplification products during each cycle of the PCR reaction. This combines the DNA amplification and detection steps into one homogeneous assay and obtes the requirement for gel electrophoresis to detect amplification products. Its simplicity, specificity, and sensitivity, together with its, more reliable instrumentation, and improved protocols, has made realtime oenLhmark technology for lite ocLuLtion of DNA. Real time PCR is extremely useful in medical microbiology, with greatest impact on virology. | train | med_mcqa | null |
Colliquative liquefaction is seen within -____after death | [
"Immediately",
"24 hours",
"72 hours",
"1 week"
] | D | o Colliquative putrefaction (liquefaction of body) is seen in 7-12 days. | train | med_mcqa | null |
A lesion of the optic radiation involving the Meyer's loop causes- | [
"homonymous hemianopia",
"Superior quadrantopia",
"Inferior quadrantopia",
"central scotoma"
] | B | B i.e. Superior quadrantopia | train | med_mcqa | null |
Irreversible cell injury shows | [
"Large flocculent mitochondrial densities",
"Cellular swelling",
"Plasma membrane blebbing",
"Loss of microvilli"
] | A | Reversible cell injury: Cellular swelling, fatty change, plasma membrane blebbing and loss of microvilli, mitochondrial swelling, dilation of the ER, eosinophilia (due to decreased cytoplasmic RNA)Features of irreversible cell injury are Cell membrane damage, Large flocculent, mitochondrial densities, Myelin figures, Nuclear changes: pyknosis, karyorrhexis, karyolysisRobbins 9th edition p.45-47 | train | med_mcqa | null |
Milkman's Fracture is a type of - | [
"Pseudofracture",
"Clavicular fracture",
"Humeral fracture",
"Metacarpal fracture"
] | A | Osteomalacia means softening of bones.Its primarilay due to deficiency of vitamin D.This results in failure of turnover of calcium and phosphorous in organic matrix of bone. C/f: Bone pains-backache and diffuse bone pains Muscular weakness:patient feels very weak.tetany may manifest as carpopedal spasm and facial twiching. Spontaneous fractures may occur in spine and may result in kyphosis. In Xray :diffuse retarction of bones. LOOSERS ZONE: thatis psuedo fractures-radioluscent zones occuring at sites of stress .common sites are pubic rami,axillary norder of scapula,ribs and medial coex of neck of femur.these are caused by rapid retarction and slow mineralisation and may be surrounded by a collar of callus.Triradiate pelvis in females. REF: Essential Ohopaedics,Maheswari &Mhaskar,Edition 5.Pg no:312 | train | med_mcqa | null |
Dissociative fugue is: Maharashtra 08 | [
"Person has sudden onset of paralysis",
"Person is fearful of a specified object",
"Person has multiple identities",
"Person flees from an immediate life situation"
] | D | Ans. Person flees from an immediate life situation | train | med_mcqa | null |
Amount of amniotic fluid at 12 weeks is - | [
"50 ml.",
"100 ml.",
"200 ml.",
"400 ml."
] | A | Ans-A | train | med_mcqa | null |
A 65 years male weighing 50 kg was admitted with 80% burn and RL was transfused with Parkland method. How much fluid should be infused in first 8 h: UP 11 | [
"200 ml/h",
"500 ml/h",
"1000 ml/h",
"8000 ml/h"
] | C | Ans. 1000 ml/h | train | med_mcqa | null |
Drug effective in ulcerative colitis is - | [
"5 amino salicyclic acid (5-ASA)",
"Steroids",
"Salazopyrin",
"Antibiotics"
] | A | null | train | med_mcqa | null |
Amount of previously unrecognized disease which is diagnosed by screening effo, is - | [
"Yield",
"Sensitivity",
"Specificity",
"PPV"
] | A | Ans. is `a' i.e., Yield Yield of the screening test: Is the amount of previously unrecognized disease that is diagnosed as result of screening effo. Yield of the screening test depends on: Sensitivity of screening test. Specificity of screening test. Prevalence of the disease in population. Paicipation of individuals in the detection programme. Yield of a screening test increases by: selecting high risk population for screening. | train | med_mcqa | null |
Most common etiological variety of uveitis is: | [
"Infective",
"Allergic",
"Toxic",
"Metabolic"
] | B | Ans. Allergic | train | med_mcqa | null |
Which of the following is used for preservation of alcohol? | [
"Potassium acetate",
"Sodium sulphide",
"Sodium fluoride",
"Glycerine"
] | C | (Sodium fluoride)
Sodium fluoride is a useful preservative in a suspected case of alcohol poisoning.
It is done with mixing 10 mL of blood with potassium oxalate & sodium fluoride (enzyme inhibitors)
for suspected alcohol poisoning.
A preservative (sodium fluoride, 0.5 -2% weight by volume) should be added after collecting a vitreous humour sample for ethanol analysis in postmortem toxicology cases.
Gastric contents can be stored in saturated salt solution. | train | med_mcqa | null |
A patient presented with a 1x1.5 cms growth on the lateral border of the tongue. The treatment indicated would be: | [
"Laser ablation",
"Interstitial brachytherapy",
"External beam radiotherapy",
"Chemotherapy"
] | B | Tumor of lateral border of tongue T1 stage (< 2cm in size): Insterstitial irradiation or excision (paial glossectomy). T2 stage (> 2 cm) in size: External beam radiotherapy or hemiglossectomy | train | med_mcqa | null |
HLA B-27 has > 90% association with? | [
"Enteropathic",
"Reactive arthritis",
"Rheumatoid arthritis",
"Ankylosing spondylitis"
] | D | Ans. (d) Ankylosing spondylitis(Ref: Harrison 18th/chapter 325)Prevalence of HLA B27 is 90% in patients with Ankylosing Spondylitis, independent of disease severity. | train | med_mcqa | null |
The virus which causes Herpes Zoster is same as that which causes | [
"Herpes simplex",
"Herpangina",
"Chicken pox",
"Measles"
] | C | null | train | med_mcqa | null |
In Korsakoff's Psychosis, the following in not seen | [
"Memory disturbances",
"Suicidal tendencies",
"Loss of recent memory",
"Pshycosis"
] | B | Suicidal tendencies | train | med_mcqa | null |
Which of the following is Y-linked disease | [
"Adreno Leukodystrophy",
"Fabry disease",
"Diabetes insipidus",
"Leri-weil dyschondrosteosis"
] | D | Y - linked inheritence
Only male to male transmission.
Only males are affected. | train | med_mcqa | null |
Mild dilated fixed pupil seen in - | [
"Acute congestive glaucoma",
"Iridocyclitis",
"Chronic congestive glaucoma",
"Open angle glaucoma"
] | A | Pupil is semi dilated veically oval and fixed. It is non-reactive to both light and accomodation. Ref: Comprehensive Ophthalmology AK Khurana 6th edition chapter-10 page no: 245 | train | med_mcqa | null |
Stone which is sensitive to lithiotripsy | [
"Calcium oxalate",
"Triple phosphate stone",
"Cystine stone",
"Uric acid stone"
] | D | In general CYTINE , calcium phosphate ( specifically brushite ) and Calcium oxalate monohydrate stones are most resistant to ESWL . The remainder of common stone type by order of increasing fragility are struvite , calcium oxalate dihydrate and finally uric acid stones. ( Radio-lucent) ref :- Campbell - Walsh urology 11th edition .chapter 53 , pg no :- 1242 Bailey and Love 27th edition . chapter 76 , pg no 1408 | train | med_mcqa | null |
Organelle that plays a pivotal role in apoptosis: | [
"Endoplasmic reticulum",
"Golgi complex",
"Mitochondria",
"Nucleus"
] | C | Mitochondrion must be recognized not only as an organelle with vital roles in intermediary metabolism and oxidative phosphorylation, but also as a central regulatory structure of apoptosis. | train | med_mcqa | null |
For satisfactory vision the minimium illumination accepted is - | [
"15 to 20 foot candles",
"30 to 40 candles",
"40 to 50 candles",
"70 to 90 candles"
] | A | An illumination of 15 to 20 foot-candles is accepted as a minimum basic requirement for satisfactory vision. 1 FC = 10.76 Lux Park's Textbook of Preventive and Social Medicine, 25th Edition, Pg 799 | train | med_mcqa | null |
Use of morphine should be avoided in all of the following patients EXCEPT? | [
"Ischemic hea disease patients",
"Bronchial asthma patients",
"Elderly male patients",
"Biliary colic patients"
] | A | Morphine is used for the treatment of myocardial infarction (ischemic hea disease) and LVF. Morphine is contra-indicated in extremes of age i.e., very young and elderly persons. It is also contra-indicated in bronchial asthma because it can cause respiratory depression and worsen the condition. By increasing intrabiliary pressure, morphine can worsen the pain of biliary colic. | train | med_mcqa | null |
A patient of total parenteral nutrition develops delayed wound healing, loss of taste, deficient immunity and diarrhea. It could be due to deficiency of: | [
"Selenium",
"Copper",
"Zinc",
"Iron"
] | C | Zinc, a trace mineral, plays a fundamental role in the overall success of many body functions and zinc deficiency can negatively affect wound healing. Plays a rolein cell division, cell growth, wound healing, and the breakdown of carbohydrates. Zincis also needed for the senses of smell and taste | train | med_mcqa | null |
Sec 304A IPC deals with | [
"Professional misconduct",
"Criminal negligence",
"Contributary negligence",
"Vicarious responsibilty"
] | B | Sec 304A IPC deals with criminal negligence " Whoever causes death of any person by doing a rash and negligent act not amounting to culpable homicide shall be punished with imprisonment upto 2 years, with fine or both" Ref: FORENSIC MEDICINE AND TOXICOLOGY Dr PC IGNATIUS THIRD EDITION PAGE 379 | train | med_mcqa | null |
Gastroesophageal reflux disease confirmed by: | [
"Manometry",
"Upper gastrointestinal endoscopy",
"24 hr pH monitoring",
"Barium meal"
] | C | Ans C.24 hr pH monitoringExplanationInvestigation for gastroesophageal reflux disease (GERD)RadiographyBarium radiology is, however, inaccurate in the diagnosis of gastroesophageal reflux, unless reflux is gross.CT to differentiate from neoplasms EndoscopyUpper gastrointestinal endoscopy is most appropriate examination if GERD is associated with dysphasiaEsophageal manometryPressure of lower esophageal shincture is also required24 hour pH and combined pH impedance monitoringGold standard for diagnosis | train | med_mcqa | null |
Chediak-Higashi syndrome is inherited as: | [
"Linked dominant trait",
"Autosomal dominant",
"Autosomal recessive",
"X-linked recessive"
] | C | Chédiak–Higashi syndrome
Autosomal recessive disease characterized by oculocutaneous albinism, immune deficiency, coagulation deficiency and neuropathy; it is that has material basis in mutations in the CHS1 gene.
Chédiak–Higashi syndrome (CHS) is a rare autosomal recessive disorder that arises from a mutation of a lysosomal trafficking regulator protein, which leads to a decrease in phagocytosis. The decrease in phagocytosis results in recurrent pyogenic infections, albinism, and peripheral neuropathy. | train | med_mcqa | null |
Which of the following is not a feature of vernal conjunctivitis | [
"Maxwell lyon sign",
"Tranta spots",
"Follicles",
"Perilimbal papillary hyperophy"
] | C | Maxwell lyon sign is presence of Eosinophils in the ropy discharge Refer: Khurana 6th edition page number 79 | train | med_mcqa | null |
"Brush heap" structure is found in: | [
"Zinc oxide impression material",
"Agar",
"Condensation silicone",
"Polyether"
] | B | null | train | med_mcqa | null |
Which of the following is the aetiological agent most often associated with Epiglottitis in children - | [
"Streptococcus pneumoniae",
"Haemophilus influenzae type b",
"Neisseria sp",
"Moraxella catarrhalis"
] | A | Ans. is (a > b) Streptococcus pneumoniae In recent days because of vaccination, cases of Epiglottitis due to Haemophilus influenzae type b have gone down drastically and thus change in option from B to A. In the past, epiglottitis was most common in children 2 to 5 years old and was usually caused by the bacterium Haemophilus influenzae type b. Now that most children are vaccinated against Haemophilus influenzae type b, the disease is quite rare and is more common among adults. In adults, and also in children now, it is typically caused by Streptococcus pneumoniae, other streptococci, and staphylococci. Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae (see Etiology) can colonize the pharynges of otherwise healthy children through respiratory transmission from intimate contact. These bacteria may penetrate the mucosal barrier, invading the bloodstream and causing bacteremia and seeding of the epiglottis and surrounding tissues. Bacteremia may also lead to infection of the meninges, skin, lungs, ears, joints, and other structures. Hib infection of the epiglottis leads to acute onset of inflammatory edema, beginning on the lingual surface of the epiglottis where the submucosa is loosely attached. Swelling significantly reduces the airway aperture. Edema rapidly progresses to involve the aryepiglottic folds, the arytenoids, and the entire supraglottic larynx. The tightly bound epithelium on the vocal cords halts edema spread at this level. Frank airway obstruction, aspiration of oropharyngeal secretions, or distal mucous plugging can cause respiratory arrest. Noninfectious inflammation of any of the structures around the epiglottis may also result from thermal or chemical injury or from local trauma, including blunt trauma to the neck. | train | med_mcqa | null |
Which is the most active single chemotherapeutic agent in the treatment of Leiomyosarcoma - | [
"Adriamycin",
"Doxorubicin",
"Methotrexate",
"b or a"
] | D | Ans. is 'b' or 'a' i.e., Doxorubicin or Adriamycin o Doxarubicin (adriamycin) has been shown to be an effective agent against leiomyosarcomas arising in the uterus. o The best responses in cases of soft tissue tumors have been observed with doxarubicin (adriamycin) and ifsofamide (not in option) | train | med_mcqa | null |
All are Flaviviruses except: | [
"HCV",
"Chikungunya",
"Yellow fever",
"Japanese B encephalitis virus"
] | B | Ans. B. Chikungunyaa. Chikungunya belongs to the genus alphavirus of the family Togaviridae.b. Two genera of medical importance in Flaviruses-I. Flavivirus: arthropod borne viruses; Yellow fever, JEV, Dengue...II. Hepacivirus: Hepatitis C virus, non-arthropod bornec. Two genera of medical importance in Toga viruses-I. Genus- Alphavirus: Chikungunya, Onyong-nyong, WEE, VEE, EEE.II. Genus- Rubivirus: Rubella. | train | med_mcqa | null |
In CLL basically which cell predominates - | [
"T cell",
"B cell",
"Lymphocyte",
"Monocyte"
] | B | null | train | med_mcqa | null |
In hand injury first structure to be repaired should be- | [
"Skin",
"Nerve",
"Muscle",
"Bone"
] | D | CSDT 13/e p1149 writes -"Bone must first be stabilized with K wires or metal plates before vascular repairs are performed. Arterial and venous repairs are done with microscopic magnification, and the ischemic tissue is reperfused."
Sabiston 18/e p1995 writes-"Although control of active hemorrhage is always a top priority, reconstruction of injured vessels must be carefully orchestrated with the management of bone and soft tissue injuries. It is preferable to achieve bone alignment before vascular reconstruction because orthopedic manipulation and reconstruction takes time and may disrupt the vascular repair. Thus, if the limb is not grossly ischemic, reduction and fixation of fractures is performed first. If the limb is ischemic, a temporary intraluminal shunt is inserted to maintain distal perfusion during the orthopedic procedure." | train | med_mcqa | null |
Daily loss of water from skin in absence of sweating is: | [
"1 litre",
"1.5 litres",
"200-300 ml",
"500-700 ml"
] | C | C i.e. 200 - 300 ml | train | med_mcqa | null |
A non symmetrical frequency distribution is known as - | [
"Normal distribution",
"Skewed distribution",
"Cumulative frequency distribution",
"None of the above"
] | B | . | train | med_mcqa | null |
Which amino acid&;s deamination takes place in liver? | [
"Alanine",
"Aspaic acid",
"Glycine",
"Glutamine"
] | D | Oxidative Deaminaton of Glutamate. Only LIVER iochondria contain glutamte dehydrogenase (GDH) which deaminates glutamteto alpha-ketoglutarate pls ammonia.So,all amino acids are first transaminated to glutamate, which is then finally deaminated ( transdeamination ) Amino acids are deaminated at the rate of about 50-60 gram per day. REFERNCE :DM VASUDEVAN TEXTBOK EIGHTH EDITION :page no; 257 | train | med_mcqa | null |
Increased amylase may be seen in all of the following except - | [
"Pancreatic pseudocyst",
"Appendicitis",
"Perforated peptic ulcer",
"Ruptured ectopic pregnancy"
] | B | null | train | med_mcqa | null |
A 30 year old male patient who has taking haloperidol for the past 1 month is brought to the emergency department with a temperature of 103.5degF, blood pressure of 176/100 mmHg, rigidity and confusion. Which one of the following seems to be the most likely possibility? | [
"Restless Legs Syndrome",
"Neuroleptic Malignant Syndrome",
"Serotonin Syndrome",
"Malignant Hyperthermia"
] | B | Ans. B. Neuroleptic malignant syndromeNeuroleptic malignant syndrome (NMS) is a life-threatening reaction that can occur in response to neuroleptic or antipsychotic medication. Symptoms include high fever, confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. Complications may include rhabdomyolysis, high blood potassium, kidney failure, or seizures.Any medications within the family of neuroleptics can cause the condition, though typical antipsychotics appear to have a higher risk than atypicals. Onset is often within a few weeks of starting the medication but can occur at any time. Risk factors include dehydration, agitation, and catatonia. Rapidly decreasing the use of levodopa may also trigger the condition. | train | med_mcqa | null |
Rose spots are seen in - | [
"Malaria",
"Chikungunya fever",
"Typhoid",
"Tuberculosis"
] | C | Ans. is 'c' i.e., Typhoido Rose spots are round maculopapular lesions seen on abdomen in patients with Enteric Fever (Typhoid), o Rose spots are rare finding :# They are present after the first week of symptoms in only 5-30% cases.# They typically last only 2-3 days.# Although the exact etiology is unclear the histopathological examination of these lesions has shown widely dilated capillaries. | train | med_mcqa | null |
Thornwaldt's abscess treatment does not include | [
"Antibiotics",
"Marsupialization",
"Removal of lining",
"Antihistaminics"
] | D | Treatment includes- Antibiotics to treat infection Marsupialization of cystic swelling Adequate removal of its lining membrane Ref: Textbook of ENT, Dhingra; 6th edition; Pg no: 245 ref img | train | med_mcqa | null |
Major site of protein glycosylation is | [
"ER and golgi body",
"Ribosome and golgi body",
"ER and ribosome",
"Ribosome and cytoplasm"
] | A | Because many glycosylation reactions occur within the lumen of the Golgi apparatus, carrier systems (permeases and transpoers) are required to transpo nucleotide sugars across the Golgi membrane.Ref: Harpers Illustrated Biochemistry, 30th edition, page no: 572 | train | med_mcqa | null |
All are true about Dermatitis herpetiformis EXCEPT : | [
"The lesions are intensely itchy",
"Lesions have epidermal bullae",
"IgA in Papillary tips",
"Associated with gluten enteropathy"
] | B | ANSWER: (B) Lesions have epidermal bullaeREF: Fitzpatrick dermatology 6th ed p. 558-73Dermatitis herpetiformis (DH) is an intensely pruritic, papulovesicular skin disease characterized by lesions symmetrically distributed over extensor surfaces (i.e., elbows, knees, buttocks, back, scalp, and posterior neck).Almost all DH patients have an associated, usually subclinical, gluten-sensitive enteropathy, and >90% express the HLA-B8/DRwT3 and HLA-DQw2 haplotypes. DH may present at any age, including childhood; onset in the second to fourth decades is most common. The disease is typically chronic.Biopsy:Small intestine shows partial villous atrophySkin lesions show sub-epidermal bullae and papillary tip abscess, IgA in papillary tips (on DIF)Treatment:Dapsone and gluten-free diet | train | med_mcqa | null |
In typhoid a permanent carrier is one who excretes bacilli for more than - | [
"3 months",
"6 months",
"1 year",
"3 years"
] | C | <p> Typhoid fever:- Typical continuous fever for 3-4 weeks,relative bradycardia with involvement of lymphoid tissue. Without effective treatment, typhoid kills over 10% of those infected. Causative agent- Salmonella typhi. S.paraA and S.paraB are infrequent. Reservoir- man Case - a case is infectious as long as bacilli appear in stools /urine. Carriers:- 1. Convalescent carriers-excrete bacilli for 6-8 weeks,after which their number dimnishes rapidly. 2. Chronic carriers- persons who excrete bacilli for more than a year after a clinical attack. In most chronic carriers,the organism persists in gall bladder and in biliary tract. Source of infection- faeces and urine of cases/carriers. Age group involved mostly is 5-19 yrs old. Males affected more than females. Incubation period- 10-14 days. Mode of transmission: faecal oral route/ urine oral routes. Treatment of carriers:- Intensive course of ampicillin/ amoxycillin (4-6g/day) together with probenecid for 6 weeks. {Reference: park&;s textbook of preventive and social medicine, 23rd edition, pg no.235}</p> | train | med_mcqa | null |
Congenital long QT syndrome can lead to - | [
"Complete hea block",
"atrial fibrillation",
"Acute myocardial infarction.",
"Recurrent ventricular tachycardia."
] | D | Long QT syndrome (LQTS) is a rare congenital and inherited or acquired hea condition in which delayed repolarisation of the hea following a heabeat increases the risk of episodes of torsades de pointes (TdP, a form of irregular heabeat that originates from the ventricles ). These episodes may lead to fainting and sudden death due to ventricular fibrillations . Episodes may be provoked by various stimuli Ref Harrison 20th edition pg 1445 | train | med_mcqa | null |
Sistrunk operation is for: | [
"Branchial cyst",
"Branchial fistula",
"Thyroglossal cyst",
"Thyroglossal fistula"
] | C | Thyroglossal cyst: - Cystic midline swelling (2-4 cm). - MC in young children. - Increases in size with upper respiratory tract infection and moves with tongue protrusion. Treatment: - Sistrunk operation: Complete surgical excision, including with it the body of the hyoid bone and core of tongue tissue around the tract in the suprahyoid tongue base to the foramen caecum. | train | med_mcqa | null |
Pearls index? | [
"Per 100 woman years",
"Per 10 woman years",
"Per 1000 woman years",
"Per 50 woman years"
] | A | Ans. is 'a' i.e., Per 100 woman years Pearl indexo Contraceptive methods are evaluated by Pearl indexo Pearl index is "failure rate per hundred women years of exposure (HWY)"Total accidental pregnanciesFailure rate per HWY = ------------------------------------------------------------- x 1200Total months of exposureo In applying the above formula, the total accidental pregnancies shown in the numerator, must include every known conception, whatever its outcome. The factor 1200 is the number of months in 100 yrs.o A failure rate of 10 per HWY would mean that in the lifetime of an average women about one fourth or 2.5 accidental pregnancies would result, since the average fertile period of a women is about 25 yrs. | train | med_mcqa | null |
Minimum infective dose of shigella is : | [
"A. 1-10",
"10-100",
"103-106",
"Same as enteric fever"
] | B | Ans: B (10-100) "It has been shown that 106 pathogenic vibrios administered to fasting normochlorhydric volunteers, without food or buffer, did not produce infection, while the same dose along with food or sodium bicarbonate caused dinical cholera in 80-100 % of them"- Ananthanarayan 9th/307"Shigella cause bacillary dysentery. Infection occurs by ingestion. The minimum infective dose is low- as few as 10-100 bacilli are capable of initiating the disease, probably because they survive gastric acidity better than other enterobacteria"- Ananthanarayan 9th/287"Enteric fever(salmonella): In human volunteer experiments, the ID 50(infective dose) was found to be about 103 to 106 bacilli - Ananthanarayan 9th/295 | train | med_mcqa | null |
In Takayasu aeritis, most common aery involved is - | [
"Common carotid aery",
"Subclan aery",
"Renal aery",
"Inferior mesenteric aery"
] | B | . Subclan aery | train | med_mcqa | null |
Which of the following virus is associated with Kaposi sarcoma? | [
"Human papillomaviruses",
"Epstein-Barr virus",
"Merkel cell virus",
"Human herpesvirus 8"
] | D | Association of Viruses with Human Cancer Human papillomaviruses Genital tumors Squamous cell carcinoma Oropharyngeal carcinoma Epstein-Barr virus Nasopharyngeal carcinoma Burkitt lymphoma Hodgkin disease B-cell lymphoma Human herpesvirus 8 Kaposi sarcoma Hepatitis B virus Hepatocellular carcinoma Merkel cell virus Merkel cell carcinoma Human T-lymphotropic virus Adult T-cell leukemia Human immunodeficiency virus AIDS-related malignancies Hepatitis C virus Hepatocellular carcinoma Ref: Brooks G.F. (2013). Chapter 43. Human Cancer Viruses. In G.F. Brooks (Ed), Jawetz, Melnick, & Adelberg's Medical Microbiology, 26e. | train | med_mcqa | null |
all of these are cluster A personality disorders except | [
"anakastic",
"schizoid",
"schizotypal",
"paranoid"
] | A | his is the most repeated question personality disorder are divided into several types and the knowledge of the classification of these disorders helps in answering a lot of questions CLUSTER A=== schizoid, paranoid, schizotypal CLUSTER B====histirionic, narcisstic, borderline, anti social CLUSTER C====anxious, anakastic, dependent Ref.Kaplon and Sadock, synopsis of psychiatry, 11 th edition, pg no.742 | train | med_mcqa | null |
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