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Vision Statement The goal of the e-Health Code of Ethics is to ensure that people worldwide can confidently and with full understanding of known risks realise the potential of the Internet in managing their own health and the health of those in their care. Introduction The Internet is changing how people give and rece...
11720928
PMC1761853
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2000 May 24; 2(2):e9
Introduction Developments on the Internet have transformed our approach to communication and dissemination of information in a number of areas. Current approaches will develop further as the dramatic growth in Internet use continues. It is particularly relevant in the area of healthcare, where the ways in which informa...
11720930
PMC1761854
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2000 Jun 23; 2(2):e11
Introduction Note: An accompanying editorial, "A Question of Duty: Legal Issues Resulting from Physician Response to Unsolicited Patient Email Inquiries,"by P. Kuszler, MD, JD, has been published in this issue. Many patients are using the Internet as a source of medical information. Mains...
11720939
PMC1761855
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2000 Sep 18; 2(3):e16
Introduction The avowed, logical, and admirable purpose of a trustmark system such as MedCERTAIN is to "establish a fully functional self- and third-party rating system enabling patients and consumers to filter harmful health information and to positively identify and select high quality information" [1]. A ratings sys...
11720941
PMC1761856
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2000 Sep 19; 2(3):e18
Commentary The topic discussed in the paper of James Till [1] is very interesting and urgent, now that medicine has also joined the preprint era with other scientific fields. The author suggests that journals may use the preprints archives as a source for finding papers to be published, going into competition to obtai...
11720938
PMC1761857
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2000 Sep 12; 2(3):e15
Patients have eagerly embraced the Internet and its email capacity to increase their knowledge and access to medical information. Along with access to countless patient support "chat rooms" and an ever-increasing volume of full text health and medical literature, the Internet also offers a virtually barrier-less opport...
11720940
PMC1761858
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2000 Sep 18; 2(3):e17
Background The establishment of BMJ's Clinical Medicine NetPrints [1] and The Lancet's Electronic Research Archive [2] websites marks an extension to clinical medicine of a novel experiment in scientific publishing. The experiment involves public access to electronic preprints, without prior peer review. The arXiv arch...
11720937
PMC1761859
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2000 Sep 1; 2(3):e14
Introduction The software used by World Wide Web (WWW) search engines continues to evolve so rapidly that keeping abreast of search features is a never-ending task. Search engines, such as Northern Light, HotBot, and AltaVista, undergo constant overhauls. Search engine software changes so frequently that help screens, ...
11720942
PMC1761860
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2000 Sep 27; 2(3):e19
Full paper published as: Terry NP. Rating the "Raters": Legal Exposure of Trustmark Authorities in the Context of Consumer Health Informatics. Journal of Medical Internet Research 2000;2(3):e18. (http://www.jmir.org/2000/3/e18/)
0
PMC1761866
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e8
An analogy to medical journals and their selection process First some general remarks: it is interesting to note that every argument brought forward by Tony against the feasibility of selecting websites for recommendation to consumers can in principle be generalized to the problem of selecting, evaluating and endorsing...
0
PMC1761867
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Dec 12; 2(Suppl 2):e14
Full paper published as: A. R. Jadad, R. B. Haynes, D. L. Hunt, and G. P. Browman. The Internet and evidence-based decision-making: a needed synergy for efficient knowledge management in health care. CMAJ 162 (3):362-365, 2000. (http://www.cma.ca/cmaj/vol-162/issue-3/0362.htm)
0
PMC1761869
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e2
Warning - this is an unedited draft, which will be replaced by a final version mid of October [will be posted at this URL]. Following a meeting convened to discuss the EU-funded MedCERTAIN project on improving information quality on the Internet, a broad group of individuals from 4 continents and 21 countries, drawn ...
0
PMC1761870
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 22; 2(Suppl 2):e11
(full paper submitted to a peer-reviewed journal) Table 1 Proposed conceptual and methodological framework for describing, comparing, and analyzing the structure and quality of e-health Structural Quality Process (Performance) Quality Outcome Quality What do we want to evaluate / improve? Communication setti...
0
PMC1761871
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e9
Full paper published as: Rippen H, Risk A, for the e-Health Ethics Initiative. e-Health Code of Ethics. Journal of Medical Internet Research 2000;2(2):e9. http://www.jmir.org/2000/2/e9/)
0
PMC1761873
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e3
In a workshop discussing the worldwide first publicly funded international trustmark project for health information on the web (MedCERTAIN), workshop participants discussed aims, possible beenfits and concerns relating to trustmarks for health information on the web. The following document attempts to summarize the iss...
0
PMC1761874
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e12
(full paper submitted to a peer-reviewed journal) Table 1 Proposed conceptual and methodological framework for describing, comparing, and analyzing the structure and quality of e-health Structural Quality Process (Performance) Quality Outcome Quality What do we want to evaluate / improve? Communication setti...
0
PMC1761875
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e13
Background The evolution of the "information age" is mirrored in the exponential growth in the number of web sites and online accessible databases, and expanding services and publications available on the Internet [1]. Many consumers and patients directly apply the information they have read on the Internet to their ow...
0
PMC1761877
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e1
Figure 1 Photograph of workshop attendees. More than 80 eHealth experts from 20 different countries and four continents attended an international workshop in Heidelberg/Germany to agree on an international scientific collaboration in the field of ehealth, to work on a metadata structure for ehealth providers and to di...
0
PMC1761878
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e10
Full paper published as: Guidelines for medical and health information sites on the Internet: principles governing AMA Web sites by Margaret A. Winker; Annette Flanagin; Bonnie Chi-Lum; John White; Karen Andrews; Robert L. Kennett; Catherine D. DeAngelis; Robert A. Musacchio (JAMA 2000 Mar22/29; 283 (12)::1600-1606)....
0
PMC1761879
CC BY
2021-01-04 22:42:36
no
J Med Internet Res. 2000 Sep 13; 2(Suppl 2):e4
Introduction Today's healthcare environments use clinical electronic records that are shared between computer systems and which may be distributed over many locations and between organizations, in order to provide information to internal users, to payers and to respond to external requests. With increasing mobility of ...
11720951
PMC1761880
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e9
Introduction In recent years, the number of people accessing the World Wide Web (WWW) has increased beyond expectation. All manner of users, from the casual surfer to the professional can avail themselves of this vast information resource, with health information and health promotion resources being prominent [1]. The ...
11720948
PMC1761881
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e6
Benefits of Online Drug Sales The use of the Internet by our nation's citizens, from school age children to seniors, has opened up vast new opportunities for the exchange of information and for enhancing commerce in all types of consumer products. Electronic mail and chat groups have dramatically facilitated communicat...
11720945
PMC1761882
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Jan 31; 3(1):e3
Introduction Electronic medical consultation as a means of health delivery is available worldwide. Although only in its infancy in New Zealand, it is likely to gain momentum and acceptance and will have an impact on both the health deliverer and the consumer. The adoption of electronic consultation could radically chan...
11720955
PMC1761883
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e13
Introduction Hospitals are rapidly adopting Intranet technology. According to a survey by PriceWaterhouseCoopers and Zinn Enterprises, the proportion of large hospitals (number of acute care beds greater than 500) with an Intranet rose from less than half of the respondents in 1999 to nearly three-quarters in 2000 [1]....
11720952
PMC1761884
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e10
Introduction Parts of patients' medical records are located in all the places where they have received clinical services (eg, community doctors, primary care, and secondary care). All of these segments, which are related to personal healthcare delivery and well being, reside in places that are disparate and, in most ca...
11720949
PMC1761885
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e7
Introduction The Global System for Mobile communication (GSM) digital wireless network that is used to transmit audio communication in cellular phones may also be used to transmit data at rates that are typically limited to 9600 bits/s. However, for access to the Internet a mobile phone needs connection to a computing ...
11720946
PMC1761886
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e4
This issue of JMIR features a provocative study which will almost certainly lead to great controversies: A "cyberdoctor" who prescribed sildenafil online compared the collected data and outcomes of his online patients with those from a traditional clinic [1]. His conclusions, based on more than 2,000 online encounters:...
11720943
PMC1761887
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Jan 31; 3(1):e1
Introduction Many European countries aim to introduce Electronic Patient Records (EPRs) as part of the modernization of their public health services. Indeed, the UK NHS (United Kingdom National Health Service) Executive [1] reported that: 2.7 The arguments for a move towards an electronic record are compelling. Such r...
11720950
PMC1761888
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e8
Introduction The U.K. National electronic Library for Health (NeLH) [1] is a Web-based, "library without walls" project announced in 1998 as part of the National Health Service (NHS) "Information for Health" strategy of the U.K. Department of Health [2]. It will be one of the cornerstones of the new NHS health informat...
11720947
PMC1761889
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e5
Introduction As the population with Internet access increases in Japan, there is a notable trend toward the use of this new information communication medium in the fields of medicine and welfare. The words "e-commerce" and "e-business" may be taken as indications of a new human economic activity based on the latest inf...
11720954
PMC1761890
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e12
Information Technology, Globalization, and Social and Geographic Inequality Two initial observations come to mind upon noting the facility with which the term "globalization" is applied to virtually everything: Enormous socio-economic differences exist, and it is known that the Internet network is mainly spreading in c...
11720953
PMC1761891
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Mar 17; 3(1):e11
Introduction Erectile dysfunction is an extremely common condition: according to the Massachusetts Male Aging Study, 52% of surveyed men aged 40 to 70 had some degree of erectile dysfunction, with dysfunction being moderate to complete in approximately half of the 70-year-old men [1]. Similarly, the National Health and...
11720944
PMC1761892
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Jan 31; 3(1):e2
Introduction The practice of medicine is rooted in a covenant of trust among patients, physicians, and society. The ethic of medicine must seek to balance the physician's responsibility to each patient and the professional, collective obligation to all who need medical care. The Council of Medical Specialty Societies...
11720965
PMC1761893
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Jun 28; 3(2):e23
Introduction Everybody talks about e-health these days, but few people have come up with a clear definition of this comparatively new term. Barely in use before 1999, this term now seems to serve as a general "buzzword," used to characterize not only "Internet medicine", but also virtually everything related to compute...
11720962
PMC1761894
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Jun 18; 3(2):e20
Introduction There are an increasing number of formats by which digital health information can be disseminated. The media that have been employed to disseminate health information since the "digital revolution" include the Internet, CD-ROMs, WAP (Wireless Application Protocol) phones, touch screen public kiosks, videoc...
11720960
PMC1761895
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 May 23; 3(2):e18
Introduction Increasingly, individuals around the world are turning to the Internet for health-related knowledge [1]. In the United States, more than 52 million adults have searched the World Wide Web for health and medical information [2]. An increasing number of health-related Web sites are now becoming available for...
11720957
PMC1761896
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Apr 9; 3(2):e15
Introduction Image-communication systems for medical images have bandwidth (data-transfer capacity) and image-size constraints that result in time-consuming connections for uncompressed raw-image data. Image compression is a key factor to improving transmission speed and storage, but it risks losing relevant medical in...
11720963
PMC1761897
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Jun 22; 3(2):e21
Introduction For the past 100,000 years, people have been able to produce, distribute, and process information in a synchronized manner. About 500 years ago, the situation started to change rapidly. With the advent of the mobile typepress, our ability to produce and distribute information started to accelerate, outpaci...
11720961
PMC1761898
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Jun 7; 3(2):e19
Introduction Continuous education is vital in the health sciences field due to the huge amounts of new data generated by the rapid growth of knowledge in the area. This gives rise to new challenges, not only for graduate professionals, but also for universities, which have to extend their role to continuous education a...
11720958
PMC1761899
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Apr 19; 3(2):e16
The first time I heard the term "e-health" I was at the 7th International Congress on Telemedicine and Telecare in London, at the end of November 1999. John Mitchell from Sidney, Australia, spoke about a national government study whose main result was the recognition that "cost-effectiveness of telemedicine and telehea...
11720964
PMC1761900
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Jun 22; 3(2):e22
Introduction A High Level Security Policy (HLSP) is a set of high-level statements intended to guide Health Care Establishment (HCE) personnel who are involved in the processing and management of sensitive health care information. It provides a set of mandatory regulations to ensure adequate security of personal health...
11720956
PMC1761901
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 Apr 6; 3(2):e14
Introduction Sophisticated consumer health information systems, supported by emerging technologies, are expected to become integral components of future medical practice [1]. Online resources have created not only the potential for health care providers to complement their usual delivery of services, but also to fundam...
11720959
PMC1761902
CC BY
2021-01-04 19:40:13
no
J Med Internet Res. 2001 May 17; 3(2):e17
Introduction Health informatics is not just information science for health professionals. One definition of health or medical informatics is that it: "Comprises the theoretical and practical aspects of information processing and communication, based on knowledge and experience derived from processes in medicine and hea...
11720968
PMC1761904
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Sep 29; 3(3):e26
We are very excited and proud to announce that in July 2001 the Journal of Medical Internet Research (JMIR) has been selected by the National Library of Medicine (NLM) to be indexed in Medline/Index Medicus, the world's most important biomedical bibliographical database. NLM uses an advisory committee, the Literature S...
11720967
PMC1761905
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Aug 28; 3(3):e25
Introduction It is crucial that patients have adequate medical information to educate, sensitize, and prepare themselves before and after undergoing medical procedures. Despite this, many fields of medicine remain unexplored by and unknown to the general public. Open-heart surgery remains one of the least-known fields,...
11720969
PMC1761906
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Sep 30; 3(3):e27
Introduction The consumer vocabulary problem Digital information technology can facilitate informed decision making by individuals and can contribute to the realization of 2 important goals of the United States (US) health care establishment. The first of these goals is the US Healthy People 2010 goal of increasing "li...
11720966
PMC1761907
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Aug 28; 3(3):e24
Introduction The main objective for a European electronic marketplace for medical devices is to establish an environment hosting all the interactions of consumers (health care organizations and professionals) and providers (manufacturers, distributors, and resellers of medical devices). This objective is to be accompli...
11772547
PMC1761912
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Dec 26; 3(4):e32
Introduction Current situation of health information on the Internet A global medium and a seismic shift There is an explosion in the amount of health information available on the Internet. This increase does not show signs of slowing down. For example, entering the word "health" in a generic search engine like Google ...
11772543
PMC1761913
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Dec 26; 3(4):e28
"An ontology is a specification of a conceptualization, i.e., a formal description of the concepts and their relations for a universe of discourse." [1] In this issue of the Journal of Medical Internet Research, Risk and Dzenowagis present a review of quality initiatives of health information on ...
11772549
PMC1761914
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Dec 31; 3(4):e34
Introduction The explosion of health information on the Internet is shifting the focus of traditional medical informatics (medical information science) from health professionals to consumers [1]. Consumer informatics is the branch of medical informatics that is concerned with studying consumers' needs for information, ...
11772546
PMC1761915
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Dec 26; 3(4):e31
Introduction Several investigators have shown that cancer patients consider information to be of great importance; further, informing patients and relatives is now an important part of cancer treatment [1,2]. During the last decade, information requests to health care workers in the Western world have steadily increase...
11772545
PMC1761916
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Dec 26; 3(4):e30
The report of Ahmad Risk and Joan Dzenowagis for the World Health Organization [1] provides a useful compendium and commentary for those who are trying to get a handle on the proliferation of quality improvement mechanisms for the health Internet. The authors identify the prevention of harm and citizen protection as th...
11772544
PMC1761917
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Dec 26; 3(4):e29
Introduction Beta-thalassaemia is a hereditary disease, which results from a mutation in the genes that are responsible for the production of hemoglobin. The hemoglobin found in healthy persons is substituted by a nonfunctional protein, thus leading to severe anemia, the onset of which usually lies between the fourth a...
11772548
PMC1761918
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2001 Dec 26; 3(4):e33
Current estimates suggest that 25 million people in the UK have access to the World Wide Web, and 14 million use it regularly [1]. Worldwide over 500 million people have logged on [2]. They have access to over 3 billion Web documents [3], and at least 2% of Web sites are health related [4]. Indeed, accessing health inf...
11956036
PMC1761925
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2002 Feb 18; 4(1):e4
Introduction Management of patients with chronic conditions is a long-standing challenge for health care organizations. These conditions include diabetes, chronic heart failure (CHF), chronic obstructive pulmonary disease (COPD), Asthma, HIV/AIDS, and cancer. Patients are required to adopt lifelong exercise, diet, and ...
11956033
PMC1761926
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2002 Jan 10; 4(1):e1
Introduction It is well recognized that cognitive behavior therapy (CBT) is an effective treatment for depression when delivered face-to-face, via self-help books (bibliotherapy), and through computer administration [1,2,3]. CBT programs have also been shown to be effective in preventing depression [4,5,6]. However, th...
11956035
PMC1761927
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Feb 15; 4(1):e3
Introduction While predictions have been made [1], little is known about how patient use of the Internet currently affects frontline clinicians. High quality information on the Internet is assumed to be vital for patients. Poor quality information presents obvious risks, including self-mistreatment and misdiagnosis (wh...
11956037
PMC1761928
CC BY
2021-01-04 19:40:14
no
J Med Internet Res. 2002 Mar 31; 4(1):e5
Introduction The importance of the Internet for contemporary public health has been acknowledged for some time. People have used the Internet for many years to access health-related information. Pallen points out that, although health professionals originally assumed that health-related Internet sites would be somethin...
11956034
PMC1761929
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Jan 17; 4(1):e2
Introduction Physicians have traditionally been the sole providers of information to patients about their diagnosis, prognosis, and treatment options. Until recently, many physicians believed that patients could not cope with bad news and should be kept ignorant of many details about their illness [1]. Many patients n...
12554556
PMC1761930
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Nov 22; 4(2):e9
Disease Management and the Internet Disease Management refers to "a set of coordinated healthcare interventions and communications for populations with conditions in which patient self-care efforts are significant." [1] Disease management supports the care plan and enhances the provider-patient relationship. It emphasi...
12554553
PMC1761931
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Nov 25; 4(2):e6
Identifying issues for qualitative research As the most comprehensive archive of written material representing our world and people's opinions, concerns, and desires (in industrialized countries), the Internet can be used to identify `issues' for qualitative (descriptive) research and to generate hypotheses. Material p...
12554560
PMC1761932
CC BY
2021-01-04 19:40:15
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J Med Internet Res. 2002 Nov 22; 4(2):e13
Introduction "We've all heard that a million monkeys banging on a million typewriters will eventually reproduce the entire works of Shakespeare. Now, thanks to the Internet, we know this is not true" [1]. Robert WilenskyThe results of a recent major national survey found that about 110 million people in the U.S. — ove...
12554557
PMC1761933
CC BY
2021-01-04 19:40:15
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J Med Internet Res. 2002 Nov 22; 4(2):e10
Introduction Health information on the Internet is pervasive with thousands of Web sites, chat rooms, and support groups [1]. Some in the medical community have espoused the potential positive impact of the Internet on increasing health education and promoting self-care [2-4]. Others have cautioned about the public hea...
12554554
PMC1761934
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Nov 22; 4(2):e7
Introduction A Decade of Development of Decision-support Tools If, 10 years ago, health communicators had learned that they could deliver programs to peoples' homes on demand, with video, data tailored to the individual user, and with a social support network in place through these programs, many may have jumped at the...
12554558
PMC1761935
CC BY
2021-01-04 19:40:15
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J Med Internet Res. 2002 Nov 22; 4(2):e11
Introduction "Every eight seconds a person dies of a tobacco-related disease and almost as quickly another victim is recruited." [1] The World Health Organization (WHO) attributes about 4 million deaths a year to tobacco use, a figure expected to rise to about 10 million deaths a year by 2030 [2]. Smoking kills 19000 ...
12554555
PMC1761936
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Nov 22; 4(2):e8
Privacy `Privacy' is a vaguely defined term that, in an online context, includes the right of an individual to: Determine what information is collected about them and how it is used. Sometimes we are not aware what data are being collected about us (e.g. via `cookies' on a Web site--see Glossary) or how it may be used...
12554559
PMC1761937
CC BY
2021-01-04 19:40:15
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J Med Internet Res. 2002 Nov 22; 4(2):e12
Critical, evidence-based evaluation of the effectiveness of information and communication technology should be one important component of eHealth [1]. In clinical medicine, randomized controlled trials (RCTs) are considered the "gold-standard" to assess the effectiveness of a treatment: next to systematic reviews, a we...
12554548
PMC1761938
CC BY
2021-01-04 19:40:15
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J Med Internet Res. 2002 Oct 17; 4(3):e17
Introduction Many persons with clinical depression or subdiagnostic symptoms of depression obtain traditional medication and/or psychotherapy services [1,2]. However,many of them, as many as 50% or more, do not obtain such traditional treatments [3]. The reasons for this seeming disconnect between disorder and treatmen...
12554545
PMC1761939
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Dec 17; 4(3):e14
Introduction It is widely recognized that utilization of information and communication technologies (ICT) can be of great benefit for the Hellenic, as well as any other, National Health System (NHS). The current penetration of information and communication technologies in the Hellenic health care sector can be summariz...
12554551
PMC1761940
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Dec 31; 4(3):e20
Introduction The Internet and emergent telecommunications infrastructures are transforming health care management as well as the dynamics of health care service markets. The costs of health care delivery systems, products, and services continue to rise everywhere, but performance of health care delivery is associated w...
12554552
PMC1761941
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Dec 31; 4(3):e21
Introduction The Internet continues to evolve as an increasingly-important source of health information for millions. Based on a national survey in March 2002, an estimated 73 million Americans have used the Internet for health information, with approximately 6 million Americans going online for health advice each day ...
12554550
PMC1761942
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Dec 31; 4(3):e19
Introduction The increased use of the Internet by ordinary people is changing the way health care providers and the general population search for and retrieve medical information, which, in turn, modifies user-provider interaction and health care delivery. Studies have evaluated the use of the Internet in different med...
12554547
PMC1761943
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Dec 20; 4(3):e16
Plastic bag suffocation as a method of suicide has been reported before but still remains unusual [1]. On the other hand, accidental deaths are not uncommon among children who play with shopping bags and among adolescents who are solvent abusers. The combination of a plastic bag and an organic solvent is highly unusual...
12554549
PMC1761944
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Oct 17; 4(3):e18
Introduction Health related web sites are now amongst the most frequently accessed sites on the internet with current estimates indicating that there are now over 100,000 sites offering health related information [1]. As a result of the wealth of information available and its apparent popularity, a number of organisati...
12554546
PMC1761945
CC BY
2021-01-04 19:40:15
no
J Med Internet Res. 2002 Nov 29; 4(3):e15
Introduction One of the common findings of research on Web-based behavior change programs is that participants spend only a relatively meager amount of time accessing their online intervention [1]. This implies minimal participant exposure to the critical behavior change ingredients of the program, which could potentia...
16954125
PMC1761946
CC BY
2021-01-04 19:40:21
no
J Med Internet Res. 2006 Aug 30; 8(3):e15
Findings Severe combined hyperlipidaemia with comparable elevation of both triglycerides and cholesterol usually has an inherited basis, such as familial dysbetalipoproteinaemia. The expression of the genetic potential for these lipid disorders is a complex process which only occurs when genetically inherited predispos...
17173705
PMC1762005
CC BY
2021-01-04 16:27:02
no
Lipids Health Dis. 2006 Dec 17; 5:29
Background Standard microarray analyses use cDNA synthesized from the poly-A tail of RNA. It requires highly intact RNA to be successful. Specimens must be obtained from intact tissues and processed immediately to avoid degradation of the RNA. Avoiding damage is difficult in clinical settings. Autopsy samples may under...
17144909
PMC1762006
CC BY
2021-01-04 16:20:12
no
BMC Clin Pathol. 2006 Dec 4; 6:9
Background In the last decade, model plants have been the subject of rapid advances in genomics, including the completion of the sequence of both Arabidopsis thaliana [1] and rice [2,3]. Knowledge gained from these studies and associated technological and methodological progresses create new prospects in a variety of b...
17166278
PMC1762007
CC BY
2021-01-04 16:20:13
no
BMC Plant Biol. 2006 Dec 13; 6:28
Background Lameness of fattening dairy and meat bulls is an animal welfare issue that also has significant economic consequences. Affected animals often suffer from osteoarthritis (OA) [1]. OA is a degenerative joint disease affecting the articular-epiphyseal cartilage complex. The aetiopathogenesis in growing bulls is...
17156437
PMC1762008
CC BY
2021-01-04 16:27:19
no
Acta Vet Scand. 2006 Dec 8; 48(1):25
Background Chromatin structure plays a critical role in all processes involving the genome of eukaryotic organisms. The first step in chromatin establishment de novo is the deposition of an (H3/H4)2 heterotetramer onto DNA by one or more of several histone chaperones including Asf1, CAF-1, and the HIR Complex. The pre-...
17166288
PMC1762009
CC BY
2021-01-04 16:20:13
no
BMC Struct Biol. 2006 Dec 13; 6:26
Background Attention deficit hyperactivity disorder (ADHD) may be the most common childhood DSM-IV diagnosis [1], with 30% to 50% of cases persisting into adulthood [2]. Research in pediatric ADHD has progressed to documenting differences in neuropsychological functioning at the level of the DSM-IV subtypes: Combined (...
17173676
PMC1762010
CC BY
2021-01-04 16:27:09
no
Behav Brain Funct. 2006 Dec 15; 2:43
Background Chronic Pancreatitis (CP) is a major health care problem worldwide and is associated with varied etiologies. CP is identified clinically by loss of endocrine and/or exocrine functions and pathologically by the presence of chronic inflammation and fibrosis of the pancreas [1,2]. Tropical calcific pancreatitis...
17163998
PMC1762011
CC BY
2021-01-04 16:20:13
no
BMC Gastroenterol. 2006 Dec 12; 6:42
Background Temperate phages integrate into the bacterial chromosome through a site-specific recombination event catalyzed by a phage-encoded recombinase. This process involves a common core present in the phage attP and the bacterial attB genomic DNA sequences, which are identical [1]. Genetic tools based on phage syst...
17173678
PMC1762012
CC BY
2021-01-04 16:22:27
no
BMC Mol Biol. 2006 Dec 15; 7:47
Background As the production and consumption of spatial data continues to increase, the subsequent use and abuse of spatially referenced data is also on the rise. Jacquez [1] provides a timely review of the key issues, outlining a number of limitations to working with spatial and temporal data. For example, one of the ...
17166283
PMC1762013
CC BY
2021-01-04 16:27:11
no
Int J Health Geogr. 2006 Dec 13; 5:58
Background Diabetes affects approximately 5% of all Canadians aged 20 years or older, with the prevalence rising with age [1] Type 2 diabetes accounts for 90% of the diagnosed cases of diabetes in Canada, while approximately 10% of diabetes cases are attributed to type 1 diabetes [1]. The National Diabetes Surveillance...
17164006
PMC1762014
CC BY
2021-01-04 16:20:13
no
BMC Health Serv Res. 2006 Dec 12; 6:159
Background Shoulder pain is common with a one-year prevalence ranging between 5% and 47% [1,2]. [3,4] In a general practice population a one-week prevalence of 21% and one-month prevalence of 18% were reported [5]. A Finnish study [6] reported a one-year incidence of shoulder pain of 14% among forestry workers. Shoulde...
17150087
PMC1762015
CC BY
2021-01-04 16:20:13
no
BMC Musculoskelet Disord. 2006 Dec 6; 7:97
Background Current estimates indicate that 30,000 people will be diagnosed with squamous cell carcinoma (SCC) of the head and neck region each year in the USA and greater than 8,000 of these patients will die of their disease. Despite recent advances in surgical reconstruction permitting larger resections in addition t...
17147827
PMC1762016
CC BY
2021-01-04 16:26:53
no
World J Surg Oncol. 2006 Dec 5; 4:87
Background Huntington disease (HD) is an autosomal dominant disorder resulting from a trinucleotide CAG expansion in the HD gene. While the expression of mutant htt is sufficient to cause HD-like symptoms with normal expression levels of wild-type htt [1-3], recent data suggests that decreased levels of wild-type htt i...
17147801
PMC1762017
CC BY
2021-01-04 16:20:13
no
BMC Neurosci. 2006 Dec 5; 7:80
Background In eukaryotic cells, histones play an important role in transcription control by packing the genomic DNA into an array of nucleosomes and higher order chromatin structure [1-3]. The amino-terminal tails of histones are rich in positively charged lysine residues which form tight contacts with the negatively c...
17156483
PMC1762018
CC BY
2021-01-04 16:26:49
no
Mol Cancer. 2006 Dec 11; 5:71
Background Tumor cell invasion is a complex process involving genetic and cellular alterations which lead to proteolysis and dispersion through three-dimensional biological barriers [1-4]. Type I collagen is the most abundant component of the extracellular matrix (ECM), and is therefore a significant obstacle for tumor...
17156449
PMC1762019
CC BY
2021-01-04 16:26:49
no
Mol Cancer. 2006 Dec 8; 5:69
Background The paradigm that cancer progression is a multi-step process, associated with multiple molecular changes as it progresses from preneoplasia to invasive carcinoma [1], has been challenged by recent molecular data. Gene expression profiling and comparative genomic hybridization (CGH) studies of breast cancer d...
17147824
PMC1762020
CC BY
2021-01-04 16:20:13
no
BMC Cancer. 2006 Dec 5; 6:275
1 Background The Outer Islands Health Care System (OIHCS) is an integral component of the Bureau of Primary Health Care (PHC), in the Republic of Marshall Island's (RMI) Ministry of Health (MOH). The OIHCS is responsible for the operations of the primary health care services to approximately 17 000 people dwelling on 1...
17173693
PMC1762021
CC BY
2021-01-04 16:27:16
no
Hum Resour Health. 2006 Dec 15; 4:27
Background Urine cytology for screening of transitional cell carcinoma (TCC) has been used for long time. Despite the advent of several newer techniques for screening and diagnosis of urothelial malignancies, cytomorphology still remains an important tool [1]. "Atypical cells" in urine have been recognized and studied ...
17169162
PMC1762022
CC BY
2021-01-04 16:26:10
no
Cytojournal. 2006 Dec 15; 3:28
Commentary In 1981 the first indication of a disturbing new illness that defied medical classification appeared in the Center for Disease Control and Prevention's Morbidity and Mortality Weekly Report [1]. Little could have prepared the scientific community – or the world – for the human catastrophe that followed. We a...
17140432
PMC1762023
CC BY
2021-01-04 16:27:10
no
Retrovirology. 2006 Dec 1; 3:85
Background Diabetes is prevalent and an important risk factor for the development of ischemic heart disease (IHD). Approximately 20% of patients with diabetes have IHD, and patients with both conditions are at particularly high risk of for adverse outcomes [1,2]. Practice guidelines recommend at least four pharmacologi...
17173679
PMC1762024
CC BY
2021-01-04 16:30:09
no
BMC Cardiovasc Disord. 2006 Dec 15; 6:48
Background With the increase in multi-center studies has come an increased need to perform cellular studies that can be standardized. The responses of blood mononuclear cells are commonly used as surrogates for in vivo immune responses to adaptive and innate immune stimuli. Performing cellular assays at a single centra...
17156490
PMC1762025
CC BY
2021-01-04 16:28:46
no
BMC Immunol. 2006 Dec 12; 7:29
I. Background Depression is a widespread condition associated with significant functional and social deterioration as well as extensive direct and indirect health care costs. A recent review of epidemiological studies estimates the annual prevalence rate of major depression at approximately 5% in Europe [1]. Within the...
17147790
PMC1762026
CC BY
2021-01-04 16:26:14
no
Cost Eff Resour Alloc. 2006 Dec 5; 4:19
Background Eukaryotic transcription is controlled by multiple factors, which may need to bind to DNA in a specific arrangement in a gene's transcriptional control region. This type of regulation system is called a cis-regulatory module (CRM). The DNA motifs (specific patterns of nucleotides) to which these factors bind...
17147812
PMC1762027
CC BY
2021-01-04 16:29:06
no
BMC Bioinformatics. 2006 Dec 5; 7:528
pmcBackground The estimation of evolutionary distances between biological sequences is at the basis of many bioinformatics problems: it plays a particularly important role in phylogenetic tree inference [1,2] and in an increasing number of comparative genomics analyses over large sets of genes or proteins (e.g. [3-5])...
17147817
PMC1762028
CC BY
2023-04-19 23:17:18
no
BMC Bioinformatics. 2006 Dec 5; 7:529
Background Mycobacterium tuberculosis complex strains (MTBC) are the causative agents of tuberculosis (TB), a disease that has a considerable detrimental impact on human and animal health worldwide [1]. This group of slow growing pathogens includes the classical M. tuberculosis, M. bovis, M. africanum, M. microti, as w...
17163995
PMC1762029
CC BY
2021-01-04 16:29:49
no
BMC Evol Biol. 2006 Dec 12; 6:107