bala1524/Drug_Combination_Extraction · Datasets at Hugging Face

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Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase .	[{'class': 'POS', 'spans': ['imatinib', 'cytarabine'], 'is_context_needed': True}]
Patient-reported outcomes of patients with advanced biliary tract cancers receiving gemcitabine plus capecitabine : a multicenter , phase II trial of the Swiss Group for Clinical Cancer Research .	[{'class': 'POS', 'spans': ['gemcitabine', 'capecitabine'], 'is_context_needed': True}]
as neoadjuvant chemotherapy , and two cycles of doxorubicin/cisplatin and ifosfamide , and two cycles of high-dose methotrexate ( 10 - 12 g/m(2 ) ) were given post-operatively .	[{'class': 'POS', 'spans': ['doxorubicin/cisplatin', 'ifosfamide', 'methotrexate'], 'is_context_needed': True}]
Reported is a case of a 58-year-old female treated in the past with cytostatics and rituximab for follicular lymphoma , in whom HBV infection was detected during a follow-up of the contacts of her partner diagnosed with acute viral hepatitis B. At the beginning , the patient had a very high serum level of HBV DNA ( 4.3 × 108 IU/mL ) and therefore she was treated with combined antiviral therapy ( lamivudine and tenofovir ) .	[{'class': 'POS', 'spans': ['lamivudine', 'tenofovir'], 'is_context_needed': True}]
Patients with wild-type KRAS exon 2 mCRC previously treated with fluorouracil- , oxaliplatin- and irinotecan-based chemotherapies were randomised ( 1:1 ) to either panitumumab plus irinotecan ( panitumumab arm ) or cetuximab plus irinotecan ( cetuximab arm ) .	[{'class': 'COMB', 'spans': ['panitumumab', 'irinotecan'], 'is_context_needed': True}, {'class': 'POS', 'spans': [6, 7], 'is_context_needed': True}]
Epirubicin , oxaliplatin , and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer ( REAL3 ):	[{'class': 'POS', 'spans': ['Epirubicin', 'oxaliplatin', 'capecitabine'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 2, 3], 'is_context_needed': True}]
In 2005 , after a significant disease-free survival benefit was reported for letrozole as compared with tamoxifen , a protocol amendment facilitated the crossover to letrozole of patients who were still receiving tamoxifen alone ; Cox models and Kaplan-Meier estimates with inverse probability of censoring weighting ( IPCW ) are used to account for selective crossover to letrozole of patients ( n=619 ) in the tamoxifen arm .	[{'class': 'NEG', 'spans': ['letrozole', 'tamoxifen'], 'is_context_needed': True}]
CEA response is associated with tumor response and survival in patients with KRAS exon 2 wild-type and extended RAS wild-type metastatic colorectal cancer receiving first-line FOLFIRI plus cetuximab or bevacizumab ( FIRE-3 trial ) .	[{'class': 'POS', 'spans': ['FOLFIRI', 'cetuximab'], 'is_context_needed': True}]
The Tamoxifen Exemestane Adjuvant Multinational ( TEAM ) phase 3 trial was conducted in hospitals in nine countries .	[{'class': 'COMB', 'spans': ['Tamoxifen', 'Exemestane'], 'is_context_needed': True}]
Patients used 2.16 ( range 0.0 - 6.3 ) formoterol and 2.34 ( range 0.1 - 7.5 ) terbutaline relief inhalations x day(-1 ) .	[{'class': 'COMB', 'spans': ['formoterol', 'terbutaline'], 'is_context_needed': True}]
Preoperative chemotherapy with FLOT ( 5-FU , leucovorin , oxaliplatin and docetaxel ) without radiation therapy is the standard treatment in the West .	[{'class': 'POS', 'spans': ['5-FU', 'leucovorin', 'oxaliplatin', 'docetaxel'], 'is_context_needed': False}]
Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway .	[{'class': 'POS', 'spans': ['Digoxin', 'gemcitabine'], 'is_context_needed': False}]
Tumor suppression was further enhanced when rapamycin was combined with 5-fluorouracil and/or oxaliplatin .	[{'class': 'POS', 'spans': ['rapamycin', '5-fluorouracil', 'oxaliplatin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]
Metformin inhibits obesity but has no effect in reducing myocardial hypertrophy caused by Rosiglitazone .	[{'class': 'NEG', 'spans': ['Metformin', 'Rosiglitazone'], 'is_context_needed': True}]
The primary endpoint of this study was to determine the maximal tolerated dose of the combination of dose-escalating curcumin and standard dose of docetaxel chemotherapy in advanced and metastatic breast cancer patients .	[{'class': 'POS', 'spans': ['curcumin', 'docetaxel'], 'is_context_needed': False}]
This case highlights the potential efficacy of combining nivolumab and regorafenib in the treatment of SBAs .	[{'class': 'POS', 'spans': ['nivolumab', 'regorafenib'], 'is_context_needed': False}]
Cutaneous T-cell lymphoma-like drug eruption in an HIV-positive patient taking vancomycin and rifampin .	[{'class': 'NEG', 'spans': ['vancomycin', 'rifampin'], 'is_context_needed': False}]
Our findings suggest that roflumilast reduces exacerbations and hospital admissions in patients with severe chronic obstructive pulmonary disease and chronic bronchitis who are at risk of frequent and severe exacerbations despite inhaled corticosteroid and longacting β2 agonist therapy , even in combination with tiotropium .	[{'class': 'POS', 'spans': ['roflumilast', 'tiotropium'], 'is_context_needed': False}]
Induction chemotherapy with cisplatin , doxorubicin , and cyclophosphamide ( CAP ) in a combined modality approach for locally advanced and inflammatory breast cancer .	[{'class': 'POS', 'spans': ['cisplatin', 'doxorubicin', 'cyclophosphamide'], 'is_context_needed': True}]
Hypertensive rats in separate groups were treated with either candesartan ( 1 mg/kg body weight ) alone or a combination of candesartan ( 1 mg/kg body weight ) and rofecoxib ( 10 mg/kg body weight ) orally and daily for 6 weeks .	[{'class': 'NEG', 'spans': ['candesartan', 'rofecoxib'], 'is_context_needed': True}]
The highest weight gain in the cyclophosphamide , methotrexate and fluorouracil group was 2·9 kg ( 5 % ) vs. 0·9 kg ( 1 % ) in the anthracycline-based group .	[{'class': 'COMB', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}]
Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma with everolimus ( RAD001 ) and alemtuzumab : a Phase I/II study .	[{'class': 'NEG', 'spans': ['everolimus', 'alemtuzumab'], 'is_context_needed': True}]
Capecitabine and oxaliplatin have been shown to be as effective as fluorouracil and cisplatin , respectively .	[{'class': 'POS', 'spans': ['Capecitabine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}]
To compare cardiopulmonary and sedative effects following administration of dexmedetomidine alone or with butorphanol , methadone , morphine or tramadol in healthy sheep .	[{'class': 'COMB', 'spans': ['dexmedetomidine', 'methadone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}]
We found that melatonin in combination with all-trans retinoic acid and somatostatin potentiated the effects of melatonin alone on MCF-7 cell viability and growth inhibition ; this phenomenon was associated with altered conductance through Ca²⁺ and voltage-activated K⁺ ( BK ) channels , and with substantial impairments of Notch-1 and epidermal growth factor (EGF)-mediated signaling .	[{'class': 'POS', 'spans': ['melatonin', 'all-trans retinoic acid', 'somatostatin'], 'is_context_needed': True}]
It was concluded that cytosine arabinoside in combination with vincristine and prednisone is an effective but toxic antileukemic regimen which did not produce a major improvement in remission duration .	[{'class': 'NEG', 'spans': ['cytosine arabinoside', 'vincristine', 'prednisone'], 'is_context_needed': False}]
Celecoxib induced a synergistic or an additive cytotoxic effect in combination with doxorubicin , etoposide , irinotecan or vincristine in vitro .	[{'class': 'POS', 'spans': ['Celecoxib', 'doxorubicin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]
Treatment of GIST882-R with imatinib in combination with gefitinib , an EGFR inhibitor , partially prevented cell growth , implying that EGFR may be involved in acquisition of secondary imatinib resistance in GIST .	[{'class': 'POS', 'spans': ['imatinib', 'gefitinib'], 'is_context_needed': False}]
This is the first paper suggesting the possibility of combination treatment of tamoxifen with risperidone in breast cancer patients , providing a conceivable resolution of tamoxifen-induced side effects without interfering the efficacy of tamoxifen against breast cancer .	[{'class': 'POS', 'spans': ['tamoxifen', 'risperidone'], 'is_context_needed': False}]
Amoxicillin , erythromycin , and levofloxacin at supra-MIC concentrations were very active against planktonic cells of 3 selected strains but lower on biofilm-associated organisms in 2 strains and null against the third .	[{'class': 'POS', 'spans': ['Amoxicillin', 'erythromycin', 'levofloxacin'], 'is_context_needed': False}]
A double-blind , parallel , placebo-controlled study was performed to assess the efficacy of a combination drug product containing the antihistamine , triprolidine , and the sympathomimetic , pseudoephedrine , in the treatment of allergic rhinitis .	[{'class': 'POS', 'spans': ['triprolidine', 'pseudoephedrine'], 'is_context_needed': True}]
After surgery , 1,384 patients were randomly assigned to receive epirubicin plus cyclophosphamide ( EC ; 90 and 600 mg/m(2 ) , respectively , × four cycles ) , followed by docetaxel ( 100 mg/m(2 ) × four cycles ; EC-T ) or epirubicin plus docetaxel ( ET ; 90 and 75 mg/m(2 ) , respectively , × four cycles ) , followed by capecitabine ( 1,250 mg/m(2 ) twice a day on days 1 to 14 , × four cycles ; ET-X ) ; all regimens were given every 3 weeks .	[{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide', 'docetaxel'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [3, 4, 5], 'is_context_needed': True}]
This prospective study recruited 152 patients with locally advanced breast cancer who underwent four-cycle weekly paclitaxel plus carboplatin without trastuzumab .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]
High response rate and acceptable toxicity of a combination of rituximab , vinorelbine , ifosfamide , mitoxantrone and prednisone for the treatment of diffuse large B-cell lymphoma in first relapse : results of the R-NIMP GOELAMS study .	[{'class': 'POS', 'spans': ['rituximab', 'vinorelbine', 'ifosfamide', 'mitoxantrone', 'prednisone'], 'is_context_needed': False}]
A second complete remission was obtained with RFC chemotherapy regimen ( rituximab , fludarabine , and cyclophosphamide ) .	[{'class': 'POS', 'spans': ['rituximab', 'fludarabine', 'cyclophosphamide'], 'is_context_needed': False}]
A favourable response to chemotherapy can be expected in up to 60 % of patients receiving a combination of streptozocin plus doxorubicin , and in up to 40 % of patients receiving dacarbazine .	[{'class': 'POS', 'spans': ['streptozocin', 'doxorubicin'], 'is_context_needed': False}]
This phase II study was conducted to establish whether induction chemotherapy with carboplatin ( CBDCA ) and paclitaxel ( PTX ) plus bevacizumab prior to surgery reduces the risk of progression .	[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'bevacizumab'], 'is_context_needed': True}]
Patients with clinically localized , intermediate- or high-grade non-Hodgkin 's lymphoma usually receive initial treatment with a doxorubicin-containing regimen such as cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) .	[{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': False}]
To evaluate the effects of a fixed combination of olmesartan/amlodipine compared with olmesartan or amlodipine alone on some parameters of endothelial damage in diabetic , hypertensive patients .	[{'class': 'POS', 'spans': ['olmesartan', 'amlodipine'], 'is_context_needed': True}]
Numerous phase II and III clinical trials have demonstrated a higher activity of combined gemcitabine plus docetaxel schedules against non-small cell lung cancer ( NSCLC ) than that of both agents in monotherapy .	[{'class': 'POS', 'spans': ['gemcitabine', 'docetaxel'], 'is_context_needed': False}]
While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an objective response rate around 20 % , the administration of combinations of irinotecan with 5-fluorouracil/folinic acid or oxaliplatin with 5-fluorouracil/folinic acid results in significantly increased response rates and improved survival .	[{'class': 'POS', 'spans': ['irinotecan', '5-fluorouracil/folinic'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}]
[ Effect of nedaplatin , 5-FU , and leucovorin combined with radiation therapy in unresectable esophageal carcinoma ] .	[{'class': 'POS', 'spans': ['nedaplatin', 'leucovorin', '5-FU'], 'is_context_needed': True}]
( 4 mg/day ) ; in group 3 , 69 patients administered metformin ( 1,000 mg/day ) and rosiglitazone ( 4 mg/day ) for 6 months ,	[{'class': 'POS', 'spans': ['metformin', 'rosiglitazone'], 'is_context_needed': True}]
The patient was treated with dexamethasone and ethinyl estradiol with cessation of anti-hypertensive therapy .	[{'class': 'COMB', 'spans': ['dexamethasone', 'ethinyl'], 'is_context_needed': True}]
When compared with the combination of amphotericin B plus flucytosine , fluconazole was similarly effective in early treatment of acute and subacute disseminated candidiasis .	[{'class': 'POS', 'spans': ['amphotericin', 'flucytosine'], 'is_context_needed': False}]
Treatment of patients over 50 years of age with acute myelogenous leukemia with a combination of rubidazone and cytosine arabinoside , vincristine , and prednisone ( ROAP ) .	[{'class': 'POS', 'spans': ['rubidazone', 'cytosine arabinoside', 'vincristine', 'prednisone'], 'is_context_needed': True}]
To compare the therapeutic effect of α(2 ) and α(4 ) integrin-blocking antibodies to conventional inflammatory bowel disease drugs methotrexate , 5-aminosalicylic acid and azathioprine in the dextran sulphate sodium mouse colitis model .	[{'class': 'POS', 'spans': ['methotrexate', '5-aminosalicylic acid', 'azathioprine'], 'is_context_needed': True}]
Further analyses demonstrated that gemcitabine could significantly interfere with the cytotoxic effects of paclitaxel on both mitotic arrest and apoptotic cell death unless paclitaxel is administered before gemcitabine .	[{'class': 'POS', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}]
Molecular targeting of Aurora A by curcumin restores chemosensitivity by increasing the efficacy of doxorubicin in breast cancer.	[{'class': 'POS', 'spans': ['curcumin', 'doxorubicin'], 'is_context_needed': True}]
Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma .	[{'class': 'POS', 'spans': ['Daratumumab', 'Lenalidomide', 'Dexamethasone'], 'is_context_needed': True}]
Randomized phase II trial of carboplatin and paclitaxel with or without lonafarnib in first-line treatment of epithelial ovarian cancer stage IIB-IV .	[{'class': 'NEG', 'spans': ['carboplatin', 'paclitaxel', 'lonafarnib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1], 'is_context_needed': True}]
One subject who received oxaprozin for 12 days and , in addition , aspirin for the last five days developed a rash that subsided after both drugs were discontinued ; one subject treated with aspirin experienced tinnitus .	[{'class': 'NEG', 'spans': ['oxaprozin', 'aspirin'], 'is_context_needed': False}]
To determine the long-term tolerability of prophylactic administration of pyrazinamide and levofloxacin in patients possibly exposed to multidrug-resistant tuberculosis ( MDRTB ) after undergoing solid organ transplantation .	[{'class': 'NEG', 'spans': ['pyrazinamide', 'levofloxacin'], 'is_context_needed': True}]
Additive effect of the combination of griseofulvin and ketoconazole against Microsporum canis in vitro .	[{'class': 'POS', 'spans': ['griseofulvin', 'ketoconazole'], 'is_context_needed': True}]
Aprepitant plus ondansetron may increase acute-CR , may have benefit regarding CINV 's effect on QoL , and is safe for 5-day temozolomide compared to ondansetron .	[{'class': 'POS', 'spans': ['Aprepitant', 'ondansetron'], 'is_context_needed': True}]
Finally , a further synergistically improved myeloma cell lysis with the daratumumab-IPH2102 combination was observed by adding lenalidomide , which suggests that more effective treatment strategies can be designed for multiple myeloma by combining daratumumab with agents that independently modulate natural killer cell function .	[{'class': 'POS', 'spans': ['lenalidomide', 'daratumumab'], 'is_context_needed': False}]
Both liposomal doxorubicin ( LD ) and docetaxel ( D ) have a broad range of activity against solid tumors , including advanced pancreatic cancer ( APC ) , as single agents , while their combination has produced encouraging response rates in the treatment of several malignancies .	[{'class': 'POS', 'spans': ['doxorubicin', 'docetaxel'], 'is_context_needed': False}]
A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats .	[{'class': 'POS', 'spans': ['cimetidine', 'L-carnitine'], 'is_context_needed': True}]
However , combination of pioglitazone and sulfasalazine has shown greater efficacy .	[{'class': 'POS', 'spans': ['pioglitazone', 'sulfasalazine'], 'is_context_needed': False}]
Phase II Study of Sorafenib Combined with Concurrent Hepatic Arterial Infusion of Oxaliplatin , 5-Fluorouracil and Leucovorin for Unresectable Hepatocellular Carcinoma with Major Portal Vein Thrombosis .	[{'class': 'POS', 'spans': ['Sorafenib', 'Oxaliplatin', '5-Fluorouracil', 'Leucovorin'], 'is_context_needed': True}]
Sprague-Dawley male rats were treated with levodopa ( LD ) , betaine ( Bet ) , levodopa plus betaine ( LD/Bet ) , levodopa plus benserazide ( LD/Ben ) , levodopa plus betaine-benserazide ( LD/Bet-Ben ) , and the controls with vehicle for 10 consecutive days , orally .	[{'class': 'POS', 'spans': ['levodopa', 'benserazide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 6, 7], 'is_context_needed': True}]
We designed a phase I trial to determine the maximum-tolerated dose ( MTD ) and pharmacodynamic effects of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer refractory to standard therapies .	[{'class': 'POS', 'spans': ['Cixutumumab', 'temsirolimus'], 'is_context_needed': True}]
Forty-seven percent of patients were sequentially treated with an amphotericin B-containing product followed by itraconazole , 31 % received itraconazole alone , and 7 % received an amphotericin B-containing product only .	[{'class': 'COMB', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}]
From August 2008 to May 2011 , consecutive chemo-naïve patients with stage IV non-squamous non-small cell lung cancer ( NSCLC ) received pemetrexed 500mg/m(2 ) , oxaliplatin 100mg/m(2 ) and bevacizumab 7.5mg/kg every 3 weeks for 6 cycles , in the outpatient setting .	[{'class': 'POS', 'spans': ['pemetrexed', 'oxaliplatin', 'bevacizumab'], 'is_context_needed': True}]
To determine if antiseptic central venous catheters impregnated with silver sulfadiazine and chlorhexidine ( antiseptic ) reduce bacterial adherence and biofilm formation without producing local or systemic toxicity .	[{'class': 'POS', 'spans': ['sulfadiazine', 'chlorhexidine'], 'is_context_needed': True}]
More than one-third ( 36 % ) of AA patients in our study received Danazol as monotherapy , whereas less than a third ( 32 % ) each received standard doses of IST with equine Anti Thymocyte Globulin ( ATG ) and Cyclosporine combination , or Cyclosporine and Danazol combination , respectively .	[{'class': 'NEG', 'spans': ['Cyclosporine', 'Danazol'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': True}]
Furthermore , our group has shown that the combination of paclitaxel and carboplatin is effective in anthracycline-resistant ABC .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': False}]
Cyclosporine ( 25 mg/kg per day , s.c . ) was given for 7 days to rats either alone or in combination with resveratrol ( 10 mg/kg per day , i.p . ) .	[{'class': 'POS', 'spans': ['Cyclosporine', 'resveratrol'], 'is_context_needed': True}]
The diagnosis was confirmed by comparative double diagnostic block of the medial branch with bupivacaine and lidocaine .	[{'class': 'COMB', 'spans': ['bupivacaine', 'lidocaine'], 'is_context_needed': True}]
Pemetrexed with bortezomib is feasible and tolerable at recommended single-agent doses .	[{'class': 'POS', 'spans': ['Pemetrexed', 'bortezomib'], 'is_context_needed': False}]
Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy ( TANIA ): an open-label , randomised phase 3 trial .	[{'class': 'POS', 'spans': ['bevacizumab', 'TANIA'], 'is_context_needed': True}]
Goserelin plus tamoxifen after cyclophosphamide , doxorubicin and 5-fluorouracil ( CAF ) chemotherapy resulted in improved disease-free survival compared with CAF alone .	[{'class': 'POS', 'spans': ['Goserelin', 'tamoxifen', 'cyclophosphamide', 'doxorubicin', '5-fluorouracil'], 'is_context_needed': False}]
An 82-year-old white female developed a 36-hour episode of unresponsiveness/drowsiness after a single dose of triazolam 0.5 mg in combination with cimetidine .	[{'class': 'NEG', 'spans': ['triazolam', 'cimetidine'], 'is_context_needed': False}]
The combination of melatonin at concentrations of 50 μM with increasing doses of irinotecan ( 7.5 , 15 , 30 , and 60 μM ) resulted in an increase in the amount of DNA damage in A549 and HT29 cancer cells , but was not effective in inducing DNA damage in healthy human lymphocytes .	[{'class': 'POS', 'spans': ['melatonin', 'irinotecan'], 'is_context_needed': False}]
Peripheral blood progenitor cells were harvested by leukapheresis after treatment with cyclophosphamide and filgrastim and then re-infused after the high-dose cycle .	[{'class': 'NEG', 'spans': ['cyclophosphamide', 'filgrastim'], 'is_context_needed': True}]
Although cisplatin is generally the favoured platinum agent , gemcitabine partnered with carboplatin is convenient to administer and has a favourable toxicity profile .	[{'class': 'POS', 'spans': ['gemcitabine', 'carboplatin'], 'is_context_needed': False}]
In group B , epirubicin 90 mg/m2 was combined with paclitaxel 175 mg/m2 , given in the same manner as in group A.	[{'class': 'POS', 'spans': ['epirubicin', 'paclitaxel'], 'is_context_needed': True}]
We assessed the safety and activity of ceritinib plus nivolumab in these patients .	[{'class': 'COMB', 'spans': ['ceritinib', 'nivolumab'], 'is_context_needed': True}]
A Phase II Randomized Study of Neoadjuvant Letrozole Plus Alpelisib for Hormone Receptor-Positive , Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer ( NEO-ORB ) .	[{'class': 'NEG', 'spans': ['Letrozole', 'Alpelisib'], 'is_context_needed': True}]
Treatment with bromocriptine and pyridoxine showed no improvement .	[{'class': 'NEG', 'spans': ['bromocriptine', 'pyridoxine'], 'is_context_needed': False}]
Bactericidal activity of trimethoprim alone and in combination with sulfamethoxazole on susceptible and resistant Escherichia coli K-12 .	[{'class': 'COMB', 'spans': ['trimethoprim', 'sulfamethoxazole'], 'is_context_needed': True}]
In a phase II trial , patients with primary gastric cancer and clinical involvement of para-aortic nodes ( PAN ) were treated by neo-adjuvant chemotherapy with capecitabine and oxaliplatin combination , and responders were then submitted to gastrectomy with D2 lymphadenectomy .	[{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': True}]
Three eyes had both bevacizumab and ranibizumab ( 1.58 % ) .	[{'class': 'COMB', 'spans': ['bevacizumab', 'ranibizumab'], 'is_context_needed': True}]
Newer treatment regimens , including etoposide , prednisone , vincristine , cyclophosphamide , doxorubicin , rituximab ( EPOCH-R ) , show promise for these patients .	[{'class': 'POS', 'spans': ['etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin', 'rituximab'], 'is_context_needed': False}]
The pupillary dilation caused by amantadine is not abolished by pretreatment with reserpine , or by combined pretreatment with reserpine and alpha-methyl-p-tyrosine , although the mydriasis is reduced by approximately 25 % .	[{'class': 'NEG', 'spans': ['amantadine', 'reserpine'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2, 3], 'is_context_needed': True}]
Rats were treated with curcumin for 23 days and etoposide was administered for the final 3 days of the experiment .	[{'class': 'POS', 'spans': ['curcumin', 'etoposide'], 'is_context_needed': True}]
Combination Chemotherapy with Mitomycin C , Vinorelbine , and Cisplatin ( MVrP ) in Patients with Advanced Non-Small Cell Lung Cancer .	[{'class': 'POS', 'spans': ['Mitomycin', 'Vinorelbine', 'Cisplatin'], 'is_context_needed': True}]
Bitches were also treated with amoxicillin ( 15 mg/kg body wt/48 h ) and/or gentamicin ( 4 mg/kg body wt/day ) administered as intramuscular ( i.m . ) injections .	[{'class': 'COMB', 'spans': ['amoxicillin', 'gentamicin'], 'is_context_needed': True}]
Fifty-seven patients with advanced measurable urothelial tract cancer , 52 of whom had an adequate trial , were treated weekly with 3 to 4 mg . per m.2 vinblastine and 30 to 40 mg . per m.2 methotrexate .	[{'class': 'POS', 'spans': ['vinblastine', 'methotrexate'], 'is_context_needed': True}]
Synergistic effects were seen between zeaxanthin and resveratrol or meclofenamic acid .	[{'class': 'POS', 'spans': ['resveratrol', 'zeaxanthin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}]
The combination of trastuzumab with paclitaxel ( Taxol ) is well approved .	[{'class': 'POS', 'spans': ['trastuzumab', 'paclitaxel'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]
Intensive regimen of combined immunosuppressive therapy ( high-dose corticosteroids , oral cyclosporin and intravenous cyclophosphamide ( IVCY , 900 - 1000 mg/m(2 ) in every other week ) ) improved the survival rate of anti-MDA5-positive patients .	[{'class': 'POS', 'spans': ['cyclosporin', 'cyclophosphamide', 'corticosteroids'], 'is_context_needed': False}]
No previous case of pulmonary interstitial changes that appeared in association with regorafenib administration for HCC and that were exacerbated by subsequent treatment with lenvatinib has been reported .	[{'class': 'NEG', 'spans': ['regorafenib', 'lenvatinib'], 'is_context_needed': False}]
Serious adverse events were reported by 24 ( 34 % ) of 71 patients receiving olaparib and abiraterone ( seven of which were related to treatment ) and 13 ( 18 % ) of 71 patients receiving placebo and abiraterone ( one of which was related to treatment ) .	[{'class': 'POS', 'spans': ['olaparib', 'abiraterone'], 'is_context_needed': True}]
Chemotherapy with methotrexate , cyclophosphamide , vincristine , doxorubicin , etoposide , and dexamethasone was effective , and the patient has been free from the disease for 1 year since completion of consolidation treatment with autologous peripheral blood stem cell transplantation .	[{'class': 'POS', 'spans': ['methotrexate', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'etoposide', 'dexamethasone'], 'is_context_needed': False}]
The effect of combined therapy with tamsulosin hydrochloride and meloxicam in patients with benign prostatic hyperplasia symptoms and impact on nocturia and sleep quality .	[{'class': 'POS', 'spans': ['tamsulosin', 'meloxicam'], 'is_context_needed': True}]
We investigated two human ( RD2 and TE 671 ) cell lines by cultivating them with doxorubicin , cisplatinum , and etoposide .	[{'class': 'COMB', 'spans': ['doxorubicin', 'etoposide', 'cisplatinum'], 'is_context_needed': True}]
Retrospective study on antihyperlipidemic efficacy and safety of simvastatin , ezetimibe and their combination in Korean adults .	[{'class': 'POS', 'spans': ['simvastatin', 'ezetimibe'], 'is_context_needed': True}]
The primary melanoma was surgically resected , and combination hepatic arterial infusion ( HAI ) therapy using dacarbazine , nimustine , vincristine ( DAV ) , and cisplatin was applied to the metastatic focus .	[{'class': 'POS', 'spans': ['dacarbazine', 'nimustine', 'vincristine', 'cisplatin'], 'is_context_needed': True}]
These results were similar to those of previously reported salvage therapies for relapsed AML including intensive chemotherapy consisting of intermediate-dose Ara-C and sequential mitoxantrone with or without etoposide ( MC/MEC ) , which we previously adopted .	[{'class': 'COMB', 'spans': ['Ara-C', 'mitoxantrone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}]

Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase .

[{'class': 'POS', 'spans': ['imatinib', 'cytarabine'], 'is_context_needed': True}]

Patient-reported outcomes of patients with advanced biliary tract cancers receiving gemcitabine plus capecitabine : a multicenter , phase II trial of the Swiss Group for Clinical Cancer Research .

[{'class': 'POS', 'spans': ['gemcitabine', 'capecitabine'], 'is_context_needed': True}]

as neoadjuvant chemotherapy , and two cycles of doxorubicin/cisplatin and ifosfamide , and two cycles of high-dose methotrexate ( 10 - 12 g/m(2 ) ) were given post-operatively .

[{'class': 'POS', 'spans': ['doxorubicin/cisplatin', 'ifosfamide', 'methotrexate'], 'is_context_needed': True}]

Reported is a case of a 58-year-old female treated in the past with cytostatics and rituximab for follicular lymphoma , in whom HBV infection was detected during a follow-up of the contacts of her partner diagnosed with acute viral hepatitis B. At the beginning , the patient had a very high serum level of HBV DNA ( 4.3 × 108 IU/mL ) and therefore she was treated with combined antiviral therapy ( lamivudine and tenofovir ) .

[{'class': 'POS', 'spans': ['lamivudine', 'tenofovir'], 'is_context_needed': True}]

Patients with wild-type KRAS exon 2 mCRC previously treated with fluorouracil- , oxaliplatin- and irinotecan-based chemotherapies were randomised ( 1:1 ) to either panitumumab plus irinotecan ( panitumumab arm ) or cetuximab plus irinotecan ( cetuximab arm ) .

[{'class': 'COMB', 'spans': ['panitumumab', 'irinotecan'], 'is_context_needed': True}, {'class': 'POS', 'spans': [6, 7], 'is_context_needed': True}]

Epirubicin , oxaliplatin , and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer ( REAL3 ):

[{'class': 'POS', 'spans': ['Epirubicin', 'oxaliplatin', 'capecitabine'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 2, 3], 'is_context_needed': True}]

In 2005 , after a significant disease-free survival benefit was reported for letrozole as compared with tamoxifen , a protocol amendment facilitated the crossover to letrozole of patients who were still receiving tamoxifen alone ; Cox models and Kaplan-Meier estimates with inverse probability of censoring weighting ( IPCW ) are used to account for selective crossover to letrozole of patients ( n=619 ) in the tamoxifen arm .

[{'class': 'NEG', 'spans': ['letrozole', 'tamoxifen'], 'is_context_needed': True}]

CEA response is associated with tumor response and survival in patients with KRAS exon 2 wild-type and extended RAS wild-type metastatic colorectal cancer receiving first-line FOLFIRI plus cetuximab or bevacizumab ( FIRE-3 trial ) .

[{'class': 'POS', 'spans': ['FOLFIRI', 'cetuximab'], 'is_context_needed': True}]

The Tamoxifen Exemestane Adjuvant Multinational ( TEAM ) phase 3 trial was conducted in hospitals in nine countries .

[{'class': 'COMB', 'spans': ['Tamoxifen', 'Exemestane'], 'is_context_needed': True}]

Patients used 2.16 ( range 0.0 - 6.3 ) formoterol and 2.34 ( range 0.1 - 7.5 ) terbutaline relief inhalations x day(-1 ) .

[{'class': 'COMB', 'spans': ['formoterol', 'terbutaline'], 'is_context_needed': True}]

Preoperative chemotherapy with FLOT ( 5-FU , leucovorin , oxaliplatin and docetaxel ) without radiation therapy is the standard treatment in the West .

[{'class': 'POS', 'spans': ['5-FU', 'leucovorin', 'oxaliplatin', 'docetaxel'], 'is_context_needed': False}]

Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway .

[{'class': 'POS', 'spans': ['Digoxin', 'gemcitabine'], 'is_context_needed': False}]

Tumor suppression was further enhanced when rapamycin was combined with 5-fluorouracil and/or oxaliplatin .

[{'class': 'POS', 'spans': ['rapamycin', '5-fluorouracil', 'oxaliplatin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]

Metformin inhibits obesity but has no effect in reducing myocardial hypertrophy caused by Rosiglitazone .

[{'class': 'NEG', 'spans': ['Metformin', 'Rosiglitazone'], 'is_context_needed': True}]

The primary endpoint of this study was to determine the maximal tolerated dose of the combination of dose-escalating curcumin and standard dose of docetaxel chemotherapy in advanced and metastatic breast cancer patients .

[{'class': 'POS', 'spans': ['curcumin', 'docetaxel'], 'is_context_needed': False}]

This case highlights the potential efficacy of combining nivolumab and regorafenib in the treatment of SBAs .

[{'class': 'POS', 'spans': ['nivolumab', 'regorafenib'], 'is_context_needed': False}]

Cutaneous T-cell lymphoma-like drug eruption in an HIV-positive patient taking vancomycin and rifampin .

[{'class': 'NEG', 'spans': ['vancomycin', 'rifampin'], 'is_context_needed': False}]

Our findings suggest that roflumilast reduces exacerbations and hospital admissions in patients with severe chronic obstructive pulmonary disease and chronic bronchitis who are at risk of frequent and severe exacerbations despite inhaled corticosteroid and longacting β2 agonist therapy , even in combination with tiotropium .

[{'class': 'POS', 'spans': ['roflumilast', 'tiotropium'], 'is_context_needed': False}]

Induction chemotherapy with cisplatin , doxorubicin , and cyclophosphamide ( CAP ) in a combined modality approach for locally advanced and inflammatory breast cancer .

[{'class': 'POS', 'spans': ['cisplatin', 'doxorubicin', 'cyclophosphamide'], 'is_context_needed': True}]

Hypertensive rats in separate groups were treated with either candesartan ( 1 mg/kg body weight ) alone or a combination of candesartan ( 1 mg/kg body weight ) and rofecoxib ( 10 mg/kg body weight ) orally and daily for 6 weeks .

[{'class': 'NEG', 'spans': ['candesartan', 'rofecoxib'], 'is_context_needed': True}]

The highest weight gain in the cyclophosphamide , methotrexate and fluorouracil group was 2·9 kg ( 5 % ) vs. 0·9 kg ( 1 % ) in the anthracycline-based group .

[{'class': 'COMB', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}]

Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma with everolimus ( RAD001 ) and alemtuzumab : a Phase I/II study .

[{'class': 'NEG', 'spans': ['everolimus', 'alemtuzumab'], 'is_context_needed': True}]

Capecitabine and oxaliplatin have been shown to be as effective as fluorouracil and cisplatin , respectively .

[{'class': 'POS', 'spans': ['Capecitabine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}]

To compare cardiopulmonary and sedative effects following administration of dexmedetomidine alone or with butorphanol , methadone , morphine or tramadol in healthy sheep .

[{'class': 'COMB', 'spans': ['dexmedetomidine', 'methadone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}]

We found that melatonin in combination with all-trans retinoic acid and somatostatin potentiated the effects of melatonin alone on MCF-7 cell viability and growth inhibition ; this phenomenon was associated with altered conductance through Ca²⁺ and voltage-activated K⁺ ( BK ) channels , and with substantial impairments of Notch-1 and epidermal growth factor (EGF)-mediated signaling .

[{'class': 'POS', 'spans': ['melatonin', 'all-trans retinoic acid', 'somatostatin'], 'is_context_needed': True}]

It was concluded that cytosine arabinoside in combination with vincristine and prednisone is an effective but toxic antileukemic regimen which did not produce a major improvement in remission duration .

[{'class': 'NEG', 'spans': ['cytosine arabinoside', 'vincristine', 'prednisone'], 'is_context_needed': False}]

Celecoxib induced a synergistic or an additive cytotoxic effect in combination with doxorubicin , etoposide , irinotecan or vincristine in vitro .

[{'class': 'POS', 'spans': ['Celecoxib', 'doxorubicin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]

Treatment of GIST882-R with imatinib in combination with gefitinib , an EGFR inhibitor , partially prevented cell growth , implying that EGFR may be involved in acquisition of secondary imatinib resistance in GIST .

[{'class': 'POS', 'spans': ['imatinib', 'gefitinib'], 'is_context_needed': False}]

This is the first paper suggesting the possibility of combination treatment of tamoxifen with risperidone in breast cancer patients , providing a conceivable resolution of tamoxifen-induced side effects without interfering the efficacy of tamoxifen against breast cancer .

[{'class': 'POS', 'spans': ['tamoxifen', 'risperidone'], 'is_context_needed': False}]

Amoxicillin , erythromycin , and levofloxacin at supra-MIC concentrations were very active against planktonic cells of 3 selected strains but lower on biofilm-associated organisms in 2 strains and null against the third .

[{'class': 'POS', 'spans': ['Amoxicillin', 'erythromycin', 'levofloxacin'], 'is_context_needed': False}]

A double-blind , parallel , placebo-controlled study was performed to assess the efficacy of a combination drug product containing the antihistamine , triprolidine , and the sympathomimetic , pseudoephedrine , in the treatment of allergic rhinitis .

[{'class': 'POS', 'spans': ['triprolidine', 'pseudoephedrine'], 'is_context_needed': True}]

After surgery , 1,384 patients were randomly assigned to receive epirubicin plus cyclophosphamide ( EC ; 90 and 600 mg/m(2 ) , respectively , × four cycles ) , followed by docetaxel ( 100 mg/m(2 ) × four cycles ; EC-T ) or epirubicin plus docetaxel ( ET ; 90 and 75 mg/m(2 ) , respectively , × four cycles ) , followed by capecitabine ( 1,250 mg/m(2 ) twice a day on days 1 to 14 , × four cycles ; ET-X ) ; all regimens were given every 3 weeks .

[{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide', 'docetaxel'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [3, 4, 5], 'is_context_needed': True}]

This prospective study recruited 152 patients with locally advanced breast cancer who underwent four-cycle weekly paclitaxel plus carboplatin without trastuzumab .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]

High response rate and acceptable toxicity of a combination of rituximab , vinorelbine , ifosfamide , mitoxantrone and prednisone for the treatment of diffuse large B-cell lymphoma in first relapse : results of the R-NIMP GOELAMS study .

[{'class': 'POS', 'spans': ['rituximab', 'vinorelbine', 'ifosfamide', 'mitoxantrone', 'prednisone'], 'is_context_needed': False}]

A second complete remission was obtained with RFC chemotherapy regimen ( rituximab , fludarabine , and cyclophosphamide ) .

[{'class': 'POS', 'spans': ['rituximab', 'fludarabine', 'cyclophosphamide'], 'is_context_needed': False}]

A favourable response to chemotherapy can be expected in up to 60 % of patients receiving a combination of streptozocin plus doxorubicin , and in up to 40 % of patients receiving dacarbazine .

[{'class': 'POS', 'spans': ['streptozocin', 'doxorubicin'], 'is_context_needed': False}]

This phase II study was conducted to establish whether induction chemotherapy with carboplatin ( CBDCA ) and paclitaxel ( PTX ) plus bevacizumab prior to surgery reduces the risk of progression .

[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'bevacizumab'], 'is_context_needed': True}]

Patients with clinically localized , intermediate- or high-grade non-Hodgkin 's lymphoma usually receive initial treatment with a doxorubicin-containing regimen such as cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) .

[{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': False}]

To evaluate the effects of a fixed combination of olmesartan/amlodipine compared with olmesartan or amlodipine alone on some parameters of endothelial damage in diabetic , hypertensive patients .

[{'class': 'POS', 'spans': ['olmesartan', 'amlodipine'], 'is_context_needed': True}]

Numerous phase II and III clinical trials have demonstrated a higher activity of combined gemcitabine plus docetaxel schedules against non-small cell lung cancer ( NSCLC ) than that of both agents in monotherapy .

[{'class': 'POS', 'spans': ['gemcitabine', 'docetaxel'], 'is_context_needed': False}]

While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an objective response rate around 20 % , the administration of combinations of irinotecan with 5-fluorouracil/folinic acid or oxaliplatin with 5-fluorouracil/folinic acid results in significantly increased response rates and improved survival .

[{'class': 'POS', 'spans': ['irinotecan', '5-fluorouracil/folinic'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}]

[ Effect of nedaplatin , 5-FU , and leucovorin combined with radiation therapy in unresectable esophageal carcinoma ] .

[{'class': 'POS', 'spans': ['nedaplatin', 'leucovorin', '5-FU'], 'is_context_needed': True}]

( 4 mg/day ) ; in group 3 , 69 patients administered metformin ( 1,000 mg/day ) and rosiglitazone ( 4 mg/day ) for 6 months ,

[{'class': 'POS', 'spans': ['metformin', 'rosiglitazone'], 'is_context_needed': True}]

The patient was treated with dexamethasone and ethinyl estradiol with cessation of anti-hypertensive therapy .

[{'class': 'COMB', 'spans': ['dexamethasone', 'ethinyl'], 'is_context_needed': True}]

When compared with the combination of amphotericin B plus flucytosine , fluconazole was similarly effective in early treatment of acute and subacute disseminated candidiasis .

[{'class': 'POS', 'spans': ['amphotericin', 'flucytosine'], 'is_context_needed': False}]

Treatment of patients over 50 years of age with acute myelogenous leukemia with a combination of rubidazone and cytosine arabinoside , vincristine , and prednisone ( ROAP ) .

[{'class': 'POS', 'spans': ['rubidazone', 'cytosine arabinoside', 'vincristine', 'prednisone'], 'is_context_needed': True}]

To compare the therapeutic effect of α(2 ) and α(4 ) integrin-blocking antibodies to conventional inflammatory bowel disease drugs methotrexate , 5-aminosalicylic acid and azathioprine in the dextran sulphate sodium mouse colitis model .

[{'class': 'POS', 'spans': ['methotrexate', '5-aminosalicylic acid', 'azathioprine'], 'is_context_needed': True}]

Further analyses demonstrated that gemcitabine could significantly interfere with the cytotoxic effects of paclitaxel on both mitotic arrest and apoptotic cell death unless paclitaxel is administered before gemcitabine .

[{'class': 'POS', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}]

Molecular targeting of Aurora A by curcumin restores chemosensitivity by increasing the efficacy of doxorubicin in breast cancer.

[{'class': 'POS', 'spans': ['curcumin', 'doxorubicin'], 'is_context_needed': True}]

Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma .

[{'class': 'POS', 'spans': ['Daratumumab', 'Lenalidomide', 'Dexamethasone'], 'is_context_needed': True}]

Randomized phase II trial of carboplatin and paclitaxel with or without lonafarnib in first-line treatment of epithelial ovarian cancer stage IIB-IV .

[{'class': 'NEG', 'spans': ['carboplatin', 'paclitaxel', 'lonafarnib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1], 'is_context_needed': True}]

One subject who received oxaprozin for 12 days and , in addition , aspirin for the last five days developed a rash that subsided after both drugs were discontinued ; one subject treated with aspirin experienced tinnitus .

[{'class': 'NEG', 'spans': ['oxaprozin', 'aspirin'], 'is_context_needed': False}]

To determine the long-term tolerability of prophylactic administration of pyrazinamide and levofloxacin in patients possibly exposed to multidrug-resistant tuberculosis ( MDRTB ) after undergoing solid organ transplantation .

[{'class': 'NEG', 'spans': ['pyrazinamide', 'levofloxacin'], 'is_context_needed': True}]

Additive effect of the combination of griseofulvin and ketoconazole against Microsporum canis in vitro .

[{'class': 'POS', 'spans': ['griseofulvin', 'ketoconazole'], 'is_context_needed': True}]

Aprepitant plus ondansetron may increase acute-CR , may have benefit regarding CINV 's effect on QoL , and is safe for 5-day temozolomide compared to ondansetron .

[{'class': 'POS', 'spans': ['Aprepitant', 'ondansetron'], 'is_context_needed': True}]

Finally , a further synergistically improved myeloma cell lysis with the daratumumab-IPH2102 combination was observed by adding lenalidomide , which suggests that more effective treatment strategies can be designed for multiple myeloma by combining daratumumab with agents that independently modulate natural killer cell function .

[{'class': 'POS', 'spans': ['lenalidomide', 'daratumumab'], 'is_context_needed': False}]

Both liposomal doxorubicin ( LD ) and docetaxel ( D ) have a broad range of activity against solid tumors , including advanced pancreatic cancer ( APC ) , as single agents , while their combination has produced encouraging response rates in the treatment of several malignancies .

[{'class': 'POS', 'spans': ['doxorubicin', 'docetaxel'], 'is_context_needed': False}]

A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats .

[{'class': 'POS', 'spans': ['cimetidine', 'L-carnitine'], 'is_context_needed': True}]

However , combination of pioglitazone and sulfasalazine has shown greater efficacy .

[{'class': 'POS', 'spans': ['pioglitazone', 'sulfasalazine'], 'is_context_needed': False}]

Phase II Study of Sorafenib Combined with Concurrent Hepatic Arterial Infusion of Oxaliplatin , 5-Fluorouracil and Leucovorin for Unresectable Hepatocellular Carcinoma with Major Portal Vein Thrombosis .

[{'class': 'POS', 'spans': ['Sorafenib', 'Oxaliplatin', '5-Fluorouracil', 'Leucovorin'], 'is_context_needed': True}]

Sprague-Dawley male rats were treated with levodopa ( LD ) , betaine ( Bet ) , levodopa plus betaine ( LD/Bet ) , levodopa plus benserazide ( LD/Ben ) , levodopa plus betaine-benserazide ( LD/Bet-Ben ) , and the controls with vehicle for 10 consecutive days , orally .

[{'class': 'POS', 'spans': ['levodopa', 'benserazide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 6, 7], 'is_context_needed': True}]

We designed a phase I trial to determine the maximum-tolerated dose ( MTD ) and pharmacodynamic effects of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer refractory to standard therapies .

[{'class': 'POS', 'spans': ['Cixutumumab', 'temsirolimus'], 'is_context_needed': True}]

Forty-seven percent of patients were sequentially treated with an amphotericin B-containing product followed by itraconazole , 31 % received itraconazole alone , and 7 % received an amphotericin B-containing product only .

[{'class': 'COMB', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}]

From August 2008 to May 2011 , consecutive chemo-naïve patients with stage IV non-squamous non-small cell lung cancer ( NSCLC ) received pemetrexed 500mg/m(2 ) , oxaliplatin 100mg/m(2 ) and bevacizumab 7.5mg/kg every 3 weeks for 6 cycles , in the outpatient setting .

[{'class': 'POS', 'spans': ['pemetrexed', 'oxaliplatin', 'bevacizumab'], 'is_context_needed': True}]

To determine if antiseptic central venous catheters impregnated with silver sulfadiazine and chlorhexidine ( antiseptic ) reduce bacterial adherence and biofilm formation without producing local or systemic toxicity .

[{'class': 'POS', 'spans': ['sulfadiazine', 'chlorhexidine'], 'is_context_needed': True}]

More than one-third ( 36 % ) of AA patients in our study received Danazol as monotherapy , whereas less than a third ( 32 % ) each received standard doses of IST with equine Anti Thymocyte Globulin ( ATG ) and Cyclosporine combination , or Cyclosporine and Danazol combination , respectively .

[{'class': 'NEG', 'spans': ['Cyclosporine', 'Danazol'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': True}]

Furthermore , our group has shown that the combination of paclitaxel and carboplatin is effective in anthracycline-resistant ABC .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': False}]

Cyclosporine ( 25 mg/kg per day , s.c . ) was given for 7 days to rats either alone or in combination with resveratrol ( 10 mg/kg per day , i.p . ) .

[{'class': 'POS', 'spans': ['Cyclosporine', 'resveratrol'], 'is_context_needed': True}]

The diagnosis was confirmed by comparative double diagnostic block of the medial branch with bupivacaine and lidocaine .

[{'class': 'COMB', 'spans': ['bupivacaine', 'lidocaine'], 'is_context_needed': True}]

Pemetrexed with bortezomib is feasible and tolerable at recommended single-agent doses .

[{'class': 'POS', 'spans': ['Pemetrexed', 'bortezomib'], 'is_context_needed': False}]

Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy ( TANIA ): an open-label , randomised phase 3 trial .

[{'class': 'POS', 'spans': ['bevacizumab', 'TANIA'], 'is_context_needed': True}]

Goserelin plus tamoxifen after cyclophosphamide , doxorubicin and 5-fluorouracil ( CAF ) chemotherapy resulted in improved disease-free survival compared with CAF alone .

[{'class': 'POS', 'spans': ['Goserelin', 'tamoxifen', 'cyclophosphamide', 'doxorubicin', '5-fluorouracil'], 'is_context_needed': False}]

An 82-year-old white female developed a 36-hour episode of unresponsiveness/drowsiness after a single dose of triazolam 0.5 mg in combination with cimetidine .

[{'class': 'NEG', 'spans': ['triazolam', 'cimetidine'], 'is_context_needed': False}]

The combination of melatonin at concentrations of 50 μM with increasing doses of irinotecan ( 7.5 , 15 , 30 , and 60 μM ) resulted in an increase in the amount of DNA damage in A549 and HT29 cancer cells , but was not effective in inducing DNA damage in healthy human lymphocytes .

[{'class': 'POS', 'spans': ['melatonin', 'irinotecan'], 'is_context_needed': False}]

Peripheral blood progenitor cells were harvested by leukapheresis after treatment with cyclophosphamide and filgrastim and then re-infused after the high-dose cycle .

[{'class': 'NEG', 'spans': ['cyclophosphamide', 'filgrastim'], 'is_context_needed': True}]

Although cisplatin is generally the favoured platinum agent , gemcitabine partnered with carboplatin is convenient to administer and has a favourable toxicity profile .

[{'class': 'POS', 'spans': ['gemcitabine', 'carboplatin'], 'is_context_needed': False}]

In group B , epirubicin 90 mg/m2 was combined with paclitaxel 175 mg/m2 , given in the same manner as in group A.

[{'class': 'POS', 'spans': ['epirubicin', 'paclitaxel'], 'is_context_needed': True}]

We assessed the safety and activity of ceritinib plus nivolumab in these patients .

[{'class': 'COMB', 'spans': ['ceritinib', 'nivolumab'], 'is_context_needed': True}]

A Phase II Randomized Study of Neoadjuvant Letrozole Plus Alpelisib for Hormone Receptor-Positive , Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer ( NEO-ORB ) .

[{'class': 'NEG', 'spans': ['Letrozole', 'Alpelisib'], 'is_context_needed': True}]

Treatment with bromocriptine and pyridoxine showed no improvement .

[{'class': 'NEG', 'spans': ['bromocriptine', 'pyridoxine'], 'is_context_needed': False}]

Bactericidal activity of trimethoprim alone and in combination with sulfamethoxazole on susceptible and resistant Escherichia coli K-12 .

[{'class': 'COMB', 'spans': ['trimethoprim', 'sulfamethoxazole'], 'is_context_needed': True}]

In a phase II trial , patients with primary gastric cancer and clinical involvement of para-aortic nodes ( PAN ) were treated by neo-adjuvant chemotherapy with capecitabine and oxaliplatin combination , and responders were then submitted to gastrectomy with D2 lymphadenectomy .

[{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': True}]

Three eyes had both bevacizumab and ranibizumab ( 1.58 % ) .

[{'class': 'COMB', 'spans': ['bevacizumab', 'ranibizumab'], 'is_context_needed': True}]

Newer treatment regimens , including etoposide , prednisone , vincristine , cyclophosphamide , doxorubicin , rituximab ( EPOCH-R ) , show promise for these patients .

[{'class': 'POS', 'spans': ['etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin', 'rituximab'], 'is_context_needed': False}]

The pupillary dilation caused by amantadine is not abolished by pretreatment with reserpine , or by combined pretreatment with reserpine and alpha-methyl-p-tyrosine , although the mydriasis is reduced by approximately 25 % .

[{'class': 'NEG', 'spans': ['amantadine', 'reserpine'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2, 3], 'is_context_needed': True}]

Rats were treated with curcumin for 23 days and etoposide was administered for the final 3 days of the experiment .

[{'class': 'POS', 'spans': ['curcumin', 'etoposide'], 'is_context_needed': True}]

Combination Chemotherapy with Mitomycin C , Vinorelbine , and Cisplatin ( MVrP ) in Patients with Advanced Non-Small Cell Lung Cancer .

[{'class': 'POS', 'spans': ['Mitomycin', 'Vinorelbine', 'Cisplatin'], 'is_context_needed': True}]

Bitches were also treated with amoxicillin ( 15 mg/kg body wt/48 h ) and/or gentamicin ( 4 mg/kg body wt/day ) administered as intramuscular ( i.m . ) injections .

[{'class': 'COMB', 'spans': ['amoxicillin', 'gentamicin'], 'is_context_needed': True}]

Fifty-seven patients with advanced measurable urothelial tract cancer , 52 of whom had an adequate trial , were treated weekly with 3 to 4 mg . per m.2 vinblastine and 30 to 40 mg . per m.2 methotrexate .

[{'class': 'POS', 'spans': ['vinblastine', 'methotrexate'], 'is_context_needed': True}]

Synergistic effects were seen between zeaxanthin and resveratrol or meclofenamic acid .

[{'class': 'POS', 'spans': ['resveratrol', 'zeaxanthin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}]

The combination of trastuzumab with paclitaxel ( Taxol ) is well approved .

[{'class': 'POS', 'spans': ['trastuzumab', 'paclitaxel'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]

Intensive regimen of combined immunosuppressive therapy ( high-dose corticosteroids , oral cyclosporin and intravenous cyclophosphamide ( IVCY , 900 - 1000 mg/m(2 ) in every other week ) ) improved the survival rate of anti-MDA5-positive patients .

[{'class': 'POS', 'spans': ['cyclosporin', 'cyclophosphamide', 'corticosteroids'], 'is_context_needed': False}]

No previous case of pulmonary interstitial changes that appeared in association with regorafenib administration for HCC and that were exacerbated by subsequent treatment with lenvatinib has been reported .

[{'class': 'NEG', 'spans': ['regorafenib', 'lenvatinib'], 'is_context_needed': False}]

Serious adverse events were reported by 24 ( 34 % ) of 71 patients receiving olaparib and abiraterone ( seven of which were related to treatment ) and 13 ( 18 % ) of 71 patients receiving placebo and abiraterone ( one of which was related to treatment ) .

[{'class': 'POS', 'spans': ['olaparib', 'abiraterone'], 'is_context_needed': True}]

Chemotherapy with methotrexate , cyclophosphamide , vincristine , doxorubicin , etoposide , and dexamethasone was effective , and the patient has been free from the disease for 1 year since completion of consolidation treatment with autologous peripheral blood stem cell transplantation .

[{'class': 'POS', 'spans': ['methotrexate', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'etoposide', 'dexamethasone'], 'is_context_needed': False}]

The effect of combined therapy with tamsulosin hydrochloride and meloxicam in patients with benign prostatic hyperplasia symptoms and impact on nocturia and sleep quality .

[{'class': 'POS', 'spans': ['tamsulosin', 'meloxicam'], 'is_context_needed': True}]

We investigated two human ( RD2 and TE 671 ) cell lines by cultivating them with doxorubicin , cisplatinum , and etoposide .

[{'class': 'COMB', 'spans': ['doxorubicin', 'etoposide', 'cisplatinum'], 'is_context_needed': True}]

Retrospective study on antihyperlipidemic efficacy and safety of simvastatin , ezetimibe and their combination in Korean adults .

[{'class': 'POS', 'spans': ['simvastatin', 'ezetimibe'], 'is_context_needed': True}]

The primary melanoma was surgically resected , and combination hepatic arterial infusion ( HAI ) therapy using dacarbazine , nimustine , vincristine ( DAV ) , and cisplatin was applied to the metastatic focus .

[{'class': 'POS', 'spans': ['dacarbazine', 'nimustine', 'vincristine', 'cisplatin'], 'is_context_needed': True}]

These results were similar to those of previously reported salvage therapies for relapsed AML including intensive chemotherapy consisting of intermediate-dose Ara-C and sequential mitoxantrone with or without etoposide ( MC/MEC ) , which we previously adopted .

[{'class': 'COMB', 'spans': ['Ara-C', 'mitoxantrone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}]