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In this phase I study , we combined cyclophosphamide , alvocidib and rituximab ( CAR ) in a schema designed to mitigate tumor lysis syndrome ( TLS ) seen previously with alvocidib . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'alvocidib', 'rituximab'], 'is_context_needed': True}] |
Sixty-two analyzable patients with predominantly intermediate-grade non-Hodgkin lymphoma received cyclophosphamide ( 200 mg/m(2 ) per day ) , doxorubicin ( 12.5 mg/m(2 ) per day ) , and etoposide ( 60 mg/m(2 ) per day ) ( CDE ) by continuous intravenous infusion for 4 days ( 96 hours ) every 3 weeks for a maximum of 8 cycles . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'doxorubicin', 'etoposide'], 'is_context_needed': True}] |
The combination carboplatin 35 mg/m2 , etoposide 50 mg/m2 , and ifosfamide 1,200 mg/m2 was administered intravenously daily for 3 consecutive days . | [{'class': 'POS', 'spans': ['carboplatin', 'etoposide', 'ifosfamide'], 'is_context_needed': True}] |
Eighty-three patients were in the control group who have performed a surgical intervention with pre-operative 120-hour antibiotic prophylaxis by Claforan ( cefotaxime ) combining with Metrogel ( metronidazole ) . | [{'class': 'POS', 'spans': ['cefotaxime', 'metronidazole'], 'is_context_needed': True}] |
The regimen was CD DP 40 mg/m2 day 1 and 6 , 5-FU 600 mg/m2 day 2 and 4 , leucovorin 20 mg/m2 day 2 and 4 , etoposide 60 mg/m2 day 3 and 5 , and doxorubicin 20 mg/m2 day 7 , with repetition every 28 days . | [{'class': 'POS', 'spans': ['CD DP', 'leucovorin', 'etoposide', 'doxorubicin', '5-FU'], 'is_context_needed': True}] |
A German Hodgkin 's lymphoma ( HL ) study group designed the BEACOPP ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , prednisolone ) regimen . | [{'class': 'POS', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisolone'], 'is_context_needed': True}] |
High-risk node-negative or low-risk node-positive breast cancer patients received AC given : ( arm I ) concurrently ( AC ) doxorubicin 54 mg/m2 and cyclophosphamide 1.2 g/m2 intravenously ( IV ) every 3 weeks for six cycles ; or ( arm II ) in sequence ( A C ) doxorubicin 40.5 mg/m2 IV days 1 and 2 every 3 weeks for four cycles followed by cyclophosphamide 2.4 gm/m2 IV every 2 weeks for three cycles . | [{'class': 'COMB', 'spans': ['doxorubicin', 'cyclophosphamide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
The CAV/PE-W consisted of 4 alternating cycles of cyclophosphamide : 500 mg/m2 , doxorubicin : 30 mg/m2 , and vincristine : 1 mg/m2 ( day 1 ) and cisplatin : 50 mg/m2 ( day 8) and etoposide : 75 mg/m2 ( days 8 and 9 ) . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'cisplatin', 'etoposide'], 'is_context_needed': True}] |
Cyclophosphamide , methotrexate , 5-fluorouracil , and folinic acid ( CMFF ) as first line chemotherapy for treatment of advanced breast cancer . | [{'class': 'COMB', 'spans': ['Cyclophosphamide', 'methotrexate', '5-fluorouracil', 'folinic acid'], 'is_context_needed': True}] |
High doses of rosuvastatin are superior to low doses of rosuvastatin plus fenofibrate or n-3 fatty acids in mixed dyslipidemia . | [{'class': 'NEG', 'spans': ['rosuvastatin', 'fenofibrate'], 'is_context_needed': False}] |
Patients were divided randomly into 3 groups ( Group A : 0.5 % bupivacaine 5 mL , n = 12 ; Group B : 0.5 % bupivacaine 4.5 mL + 20 mg of triamcinolone 0.5 mL , n = 10 ; and Group C : 0.5 % bupivacaine 4 mL + 40 mg of triamcinolone 1 mL , n = 10 ) . | [{'class': 'POS', 'spans': ['bupivacaine', 'triamcinolone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [3, 4], 'is_context_needed': True}] |
Irinotecan and etoposide were combined using the ( d x 5)2 i.v . schedule for both drugs , in which irinotecan was given 2 h before or 2 h after the administration of etoposide . | [{'class': 'NEG', 'spans': ['Irinotecan', 'etoposide'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [2, 3], 'is_context_needed': True}] |
Combination of sofosbuvir , pegylated-interferon and ribavirin for treatment of hepatitis C virus genotype 1 infection : a systematic review and meta-analysis . | [{'class': 'POS', 'spans': ['sofosbuvir', 'pegylated-interferon', 'ribavirin'], 'is_context_needed': True}] |
Immunosuppressive protocol : preoperative : Cyclosporin + Azathioprine . | [{'class': 'COMB', 'spans': ['Cyclosporin', 'Azathioprine'], 'is_context_needed': True}] |
First , we searched for the most synergistic combination of KPT-8602 with dexamethasone , vincristine , or doxorubicin | [{'class': 'POS', 'spans': ['KPT-8602', 'dexamethasone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}] |
Epidural analgesia during labor--0.5 % lidocaine with fentanyl vs. 0.08 % ropivacaine with fentanyl . | [{'class': 'COMB', 'spans': ['lidocaine', 'fentanyl'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
The proactive intense care strategy was applied , which includes : ( i ) an education and training course on the topic of SLE-PAH for ED physicians ; ( ii ) a SLE-PAH patient triage protocol with prompt specialist consultation and admission ; and ( iii ) intensive care with prompt initiation of combination PAH-targeted therapy , that is , at least two drugs from the three categories as represented by iloprost , bosentan and sildenafil . | [{'class': 'POS', 'spans': ['iloprost', 'bosentan', 'sildenafil'], 'is_context_needed': True}] |
Adding sulbactam to piperacillin resulted in increased susceptibility rates among piperacillin-resistant P. aeruginosa ( 53 - 57 % in either 2:1 or 4:1 ratios ) and A. baumannii ( 38 - 46 % in either 2:1 ratio or a fixed 8 mg/L concentration of sulbactam ) isolates . | [{'class': 'POS', 'spans': ['sulbactam', 'piperacillin'], 'is_context_needed': False}] |
Preoperative treatment was 5 fractions radiation therapy ( 25 Gy to involved mesorectum , 20 Gy to elective nodes ) , followed by 4 cycles of FOLFOX [ 5-fluorouracil , oxaliplatin , leucovorin ] . | [{'class': 'POS', 'spans': ['oxaliplatin', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
The cost-effectiveness of dapagliflozin versus sulfonylurea as an add-on to metformin in the treatment of Type 2 diabetes mellitus . | [{'class': 'POS', 'spans': ['dapagliflozin', 'metformin'], 'is_context_needed': True}] |
This study aimed to investigate the efficacy and safety of iguratimod ( T-614 ) in combination with methotrexate ( MTX ) for active rheumatoid arthritis ( RA ) patients . | [{'class': 'POS', 'spans': ['iguratimod', 'methotrexate'], 'is_context_needed': True}] |
Cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) or CHOP-like regimens have been the backbone while more intensive regimens such as cyclophosphamide , vincristine , doxorubicin , high-dose methotrexate/ifosfamide , etoposide , high-dose cytarabine ( CODOX-M/IVAC ) , or dose-adjusted etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( DA-EPOCH ) are possible options . | [{'class': 'COMB', 'spans': ['Cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5, 6, 7, 8, 14], 'is_context_needed': True}, {'class': 'COMB', 'spans': [9, 10, 11, 12, 13], 'is_context_needed': True}] |
[ Intraoperative anaphylactic shock induced by methylergometrine and oxytocin ] . | [{'class': 'COMB', 'spans': ['methylergometrine', 'oxytocin'], 'is_context_needed': True}] |
[ An elderly patient with myelodysplastic syndrome successfully treated with combination of granulocyte-colony stimulating factor and continuous-drip infusion of low-dose cytarabine and etoposide ] . | [{'class': 'POS', 'spans': ['cytarabine', 'etoposide'], 'is_context_needed': False}] |
Among the GNB , a higher prevalence of resistance was observed against cefoxitin ( 93.1 % ) followed by ampicillin ( 79.4 % ) , chloramphenicol ( 72.6 % ) , ceftizoxime ( 65.7 % ) , aztreonam ( 64.9 % ) , cefotaxime ( 53.6 % ) , imipenem ( 38.3 % ) , ceftazidime ( 33.5 % ) , gentamicin ( 32.6 % ) , tetracycline ( 22.2 % ) , and ciprofloxacin ( 19.8 % ) . | [{'class': 'COMB', 'spans': ['cefoxitin', 'ampicillin', 'chloramphenicol', 'ceftizoxime', 'aztreonam', 'cefotaxime', 'imipenem', 'ceftazidime', 'gentamicin', 'tetracycline', 'ciprofloxacin'], 'is_context_needed': True}] |
The results suggested that irinotecan , 5-FU and leucovorin combination chemotherapy in a biweekly schedule is a practical and tolerable treatment option in patients with advanced colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', '5-FU', 'leucovorin'], 'is_context_needed': False}] |
Terlipressin administration in rats pre-treated with octreotide further decreased portal pressure , portal tributary blood flow and increased hepatocollateral vascular resistance ; terlipressin increased arterial pressure and further decreased cardiac index . | [{'class': 'COMB', 'spans': ['Terlipressin', 'octreotide'], 'is_context_needed': True}] |
Docetaxel and cisplatin were given at 75 mg/m(2 ) , while capecitabine was initially given at 500 mg/m(2 ) twice a day and subsequently escalated . | [{'class': 'NEG', 'spans': ['Docetaxel', 'cisplatin', 'capecitabine'], 'is_context_needed': True}] |
A colorectal cancer cell line ( LOVO cell ) treated by curcumin combined with irinotecan in different ways respectively was used as our comparative model . | [{'class': 'POS', 'spans': ['curcumin', 'irinotecan'], 'is_context_needed': True}] |
The use of ceftriaxone plus doxycycline as an initial empiric therapy for patients hospitalized with CAP appears safe and effective , and its potential superiority should be evaluated prospectively . | [{'class': 'POS', 'spans': ['doxycycline', 'plus'], 'is_context_needed': False}] |
Metformin ( 50 mg/kg/day ) , genistein ( 20 mg/kg/day ) and combination of genistein and metformin was administered in alloxan-induced diabetic rats . | [{'class': 'POS', 'spans': ['genistein', 'metformin'], 'is_context_needed': True}] |
Here we report the results of a multicenter retrospective trial evaluating ASCT in patients with transformed lymphoma using the Z-BEAM conditioning regimen , which combines yttrium-90-labeled ibritumomab tiuxetan ( Zevalin ) with high-dose BEAM ( carmustine , etoposide , cytarabine , melphalan ) chemotherapy . | [{'class': 'POS', 'spans': ['ibritumomab tiuxetan', 'carmustine', 'etoposide', 'cytarabine', 'melphalan'], 'is_context_needed': True}] |
Palbociclib is a selective cyclin-dependent kinase ( CDK ) 4/6 inhibitor used in combination with aromatase inhibitors or fulvestrant for patients with hormone receptor-positive ( HR+ ) human epidermal growth factor receptor 2 (HER2)-negative advanced/metastatic breast cancer ( ABC/MBC ) . | [{'class': 'POS', 'spans': ['Palbociclib', 'fulvestrant'], 'is_context_needed': True}] |
Triplet schedule of weekly 5-fluorouracil and alternating irinotecan or oxaliplatin in advanced colorectal cancer : a dose-finding and phase II study . | [{'class': 'POS', 'spans': ['5-fluorouracil', 'irinotecan', 'oxaliplatin'], 'is_context_needed': True}] |
Concomitant and sequential treatment with paclitaxel and gemcitabine had no significant difference in terms of PFS . | [{'class': 'COMB', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}] |
We compared such treatment with docetaxel plus prednisone in men with this disease . | [{'class': 'POS', 'spans': ['docetaxel', 'prednisone'], 'is_context_needed': True}] |
Combination chemotherapy has been established to have superior response rates and progression-free survival and -- in some instances , for fluorouracil and irinotecan combinations -- improved overall survival compared to fluorouracil alone . | [{'class': 'POS', 'spans': ['fluorouracil', 'irinotecan'], 'is_context_needed': False}] |
Phase IV study of bevacizumab in combination with infusional fluorouracil , leucovorin and irinotecan ( FOLFIRI ) in first-line metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['bevacizumab', 'fluorouracil', 'leucovorin', 'irinotecan'], 'is_context_needed': True}] |
Nine patients received a combination of cisplatin and etoposide ( EP ) , 5 had cyclophosphamide , doxorubicin and vincristine , 1 had cyclophosphamide , etoposide and vincristine and 1 had monotherapy with oral etoposide . | [{'class': 'COMB', 'spans': ['cisplatin', 'etoposide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [5, 6, 7], 'is_context_needed': True}] |
Comparing the combination of nalidixic acid and metronidazole with metronidazole alone , 17.5 % more children treated with the combination recovered by day 3 of treatment ( p = 0.08 ) and the mean stool frequency ascertained on day 7 for the previous 24 h was 26.8 % less in them ( p = 0.05 ) . | [{'class': 'POS', 'spans': ['nalidixic acid', 'metronidazole'], 'is_context_needed': False}] |
The management is primarily based on pharmacological agents and in clinical practice propranolol and primidone are considered the first-line therapy . | [{'class': 'POS', 'spans': ['propranolol', 'primidone'], 'is_context_needed': True}] |
ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy . | [{'class': 'COMB', 'spans': ['oxaliplatin', 'fluorouracil'], 'is_context_needed': True}] |
7 patients ( 53 % ) receiving pamidronate and thalidomide therapy demonstrated good response involving at least 25 % reduction of monoclonal protein levels in comparison with baseline . | [{'class': 'POS', 'spans': ['pamidronate', 'thalidomide'], 'is_context_needed': False}] |
A similar relapse rate was also obtained with a 6-month completely oral regimen including TMC207 , moxifloxacin and pyrazinamide but excluding both amikacin and ethionamide . | [{'class': 'POS', 'spans': ['TMC207', 'moxifloxacin', 'pyrazinamide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2, 3, 4], 'is_context_needed': True}] |
Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma : Safety , Tolerability , and Preliminary Evidence of Antitumor Activity . | [{'class': 'POS', 'spans': ['Propranolol', 'Pembrolizumab'], 'is_context_needed': True}] |
Sequential exposure of vinorelbine preceding paclitaxel or prolonged exposure to both agents concurrently needs to be tested clinically to determine whether the antitumor activity of this combination can be enhanced . | [{'class': 'POS', 'spans': ['vinorelbine', 'paclitaxel'], 'is_context_needed': True}] |
Favorable Response of Metastatic Hepatocellular Carcinoma to Treatment with Trans-arterial Radioembolization Followed by Sorafenib and Nivolumab . | [{'class': 'POS', 'spans': ['Sorafenib', 'Nivolumab'], 'is_context_needed': True}] |
In 23 adult patients , surgery , postoperative radiotherapy ( 60 Gy in 30 daily fractions within 6 weeks ) , and adjuvant modified chemotherapy ( procarbazine 60 mg/m(2 ) on Days 1 - 14 , lomustine 100 mg/m(2 ) on Day 1 , and vincristine 1.4 mg/m(2 ) [ maximum 2 mg ] on Days 1 and 8) were administered every 6 weeks for up to six cycles or until progression occurred . | [{'class': 'POS', 'spans': ['procarbazine', 'lomustine', 'vincristine'], 'is_context_needed': True}] |
This phase 1 trial determined the safety , pharmacokinetics , and antitumor activity of LY3022855 in combination with durvalumab or tremelimumab in patients with advanced solid cancers who had received standard anti-cancer treatments . | [{'class': 'POS', 'spans': ['LY3022855', 'durvalumab'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}] |
Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with Type 2 diabetes . | [{'class': 'POS', 'spans': ['vildagliptin', 'voglibose'], 'is_context_needed': True}] |
Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning . | [{'class': 'POS', 'spans': ['paroxetine', 'fluvoxamine'], 'is_context_needed': True}] |
Phase 3 data support the use of sunitinib , bevacizumab plus interferon-α and pazopanib for patients with low and intermediate risk of clear-cell renal cell carcinoma . | [{'class': 'POS', 'spans': ['sunitinib', 'bevacizumab', 'pazopanib', 'interferon-α'], 'is_context_needed': True}] |
This study is designed to find out the efficacy and toxicity of the combination of oxaliplatin and gemcitabine in the treatment of advanced non-small cell lung cancer ( NSCLC ) . | [{'class': 'POS', 'spans': ['oxaliplatin', 'gemcitabine'], 'is_context_needed': True}] |
All patients received 900 mg/m2 bolus of cyclophosphamide intravenously daily for 3 consecutive days with a concurrent infusion of 150 mg/m2 of paclitaxel over 72 h ( 50 mg/m2/d ) . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'paclitaxel'], 'is_context_needed': True}] |
Rituximab combined with a small dose of melphalan for a refractory follicular lymphoma patient . | [{'class': 'POS', 'spans': ['Rituximab', 'melphalan'], 'is_context_needed': True}] |
Accumulated doses of cyclophosphamide , procarbazine , doxorubicin , mitoxantrone , and etoposide were 18,300 mg , 3000 mg , 580 mg , 100 mg , and 4150 mg , respectively , which had been administered for the treatment of NHL . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'procarbazine', 'doxorubicin', 'mitoxantrone', 'etoposide'], 'is_context_needed': True}] |
In newly diagnosed patients with MCL ineligible for intensive therapy and ASCT , the standard-of-care has generally been R-CHOP ( rituximab , cyclophosphamide , doxorubicin , vincristine , and prednisone ) , followed by rituximab , maintenance . | [{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone', 'rituximab'], 'is_context_needed': False}] |
The results indicate that BU and IPSA behave additively with verapamil and carbamazepine , which may be due to a common action on the same subtype of calcium channels . | [{'class': 'POS', 'spans': ['BU', 'IPSA', 'verapamil', 'carbamazepine'], 'is_context_needed': False}] |
The combination of docetaxel and trastuzumab is well tolerated and has clinically meaningful antitumor activity . | [{'class': 'POS', 'spans': ['docetaxel', 'trastuzumab'], 'is_context_needed': False}] |
Combined treatment using insulin-like growth factor-I with prednisolone or ursodeoxycholic acid additively increased bile flow volume . | [{'class': 'POS', 'spans': ['insulin-like growth factor-I', 'prednisolone'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells . | [{'class': 'POS', 'spans': ['gemcitabine', 'trabectedin'], 'is_context_needed': True}] |
Conversely , down-regulation of cyclin E1 gene expression or inhibition of cyclin E1 by the cyclin-dependent kinase ( CDK ) inhibitors dinaciclib ( DIN ) or flavopiridol sensitized HCC cells to regorafenib and sorafenib by inducing apoptosis . | [{'class': 'POS', 'spans': ['flavopiridol', 'regorafenib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}] |
Cytarabine and etoposide intensification exceeded the acceptable toxic death rate of 10 % . | [{'class': 'NEG', 'spans': ['Cytarabine', 'etoposide'], 'is_context_needed': False}] |
After initiating warfarin plus lenvatinib , INR assays are necessary . | [{'class': 'COMB', 'spans': ['warfarin', 'lenvatinib'], 'is_context_needed': True}] |
Merimepodib ( MMPD ) is an orally administered , inosine monophosphate dehydrogenase inhibitor that has shown antiviral activity in nonresponders with chronic hepatitis C ( CHC ) when combined with pegylated interferon alfa 2a ( Peg-IFN-alfa-2a ) and ribavirin ( RBV ) . | [{'class': 'POS', 'spans': ['interferon alfa', 'ribavirin', 'Merimepodib'], 'is_context_needed': False}] |
[ Effects of endostatin and doxycycline on microcirculation patterns in melanoma and their relevant molecular mechanisms ] . | [{'class': 'COMB', 'spans': ['endostatin', 'doxycycline'], 'is_context_needed': True}] |
Subsequent investigation of therapeutic responsiveness upon treatment with the current systemic gold standard EDP-M ( etoposide , doxorubicin , cisplatin and mitotane ) demonstrated maintenance of the clinically observed drug resistance for MUC-1 exclusively . | [{'class': 'POS', 'spans': ['etoposide', 'doxorubicin', 'cisplatin', 'mitotane'], 'is_context_needed': True}] |
Oxaliplatin is active in NSCLC , offers advantage in terms of toxicity , and shows synergism with gemcitabine . | [{'class': 'POS', 'spans': ['Oxaliplatin', 'gemcitabine'], 'is_context_needed': False}] |
Doxorubicin and lapatinib combination nanomedicine for treating resistant breast cancer . | [{'class': 'POS', 'spans': ['Doxorubicin', 'lapatinib'], 'is_context_needed': True}] |
The HIV protease inhibitor ritonavir , a strong CYP3A4 inhibitor , decreased first-pass metabolism of orally administered docetaxel . | [{'class': 'POS', 'spans': ['ritonavir', 'docetaxel'], 'is_context_needed': False}] |
Ramucirumab plus osimertinib demonstrated encouraging safety and antitumor activity in T790M-positive EGFR-mutant NSCLC . | [{'class': 'POS', 'spans': ['Ramucirumab', 'osimertinib'], 'is_context_needed': False}] |
The patient was complicated with hemophagocytic lymphohistiocytosis ( HLH ) and invasive aspergillosis ( IPA ) after re-induction treatment with FLAG-IDA following etoposide , cytarabine , and mitoxantrone . | [{'class': 'COMB', 'spans': ['etoposide', 'cytarabine', 'mitoxantrone'], 'is_context_needed': True}] |
Pretreatment of the rats with methamphetamine ( MAP ) for 8 days prior to chronic haloperidol significantly enhanced the DOPAC and HVA increase produced by the challenge with haloperidol in both brain areas . | [{'class': 'POS', 'spans': ['methamphetamine', 'haloperidol'], 'is_context_needed': False}] |
The quantity and composition of bacterial communities were altered by treatment with the five-antibiotic cocktail and by treatment with vancomycin and ampicillin . | [{'class': 'COMB', 'spans': ['vancomycin', 'ampicillin'], 'is_context_needed': True}] |
Successful treatment of an elderly Langerhans cell sarcoma patient by EPOCH ( etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ) chemotherapy . | [{'class': 'POS', 'spans': ['etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': False}] |
Tremelimumab plus gemcitabine demonstrated a safety and tolerability profile , warranting further study in patients with metastatic pancreatic cancer . | [{'class': 'POS', 'spans': ['Tremelimumab', 'gemcitabine'], 'is_context_needed': True}] |
Longer progression-free survival ( PFS ) and overall survival ( OS ) were observed with T-DM1 compared with capecitabine plus lapatinib in all biomarker subgroups . | [{'class': 'COMB', 'spans': ['capecitabine', 'lapatinib'], 'is_context_needed': True}] |
Pharmacokinetics , Safety , and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer : Phase Ib Study . | [{'class': 'POS', 'spans': ['Apalutamide', 'Abiraterone', 'Prednisone'], 'is_context_needed': True}] |
Combined treatment with nintedanib ( 200 mg/bid ) plus letrozole ( 2.5 mg/day ) effectively suppressed FGFR1 and aromatase activity , and these respective doses can be used as starting doses in any subsequent trials . | [{'class': 'POS', 'spans': ['nintedanib', 'letrozole'], 'is_context_needed': False}] |
A significant response to a combination of trastuzumab and vinorelbine in HER2-negative metastatic breast cancer with HER2 V777L mutation . | [{'class': 'POS', 'spans': ['trastuzumab', 'vinorelbine'], 'is_context_needed': False}] |
Patients ( n = 28 ) with metastatic solid tumors were randomized to receive pretreatment with Dex or GM-CSF or no pretreatment prior to courses 1 or 2 of carboplatin and ifosfamide . | [{'class': 'POS', 'spans': ['carboplatin', 'ifosfamide', 'Dex'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 3], 'is_context_needed': True}] |
After a thyroidectomy , she was treated with intravenous methylprednisolone pulse therapy and oral prednisolone followed by tacrolimus therapy . | [{'class': 'NEG', 'spans': ['methylprednisolone', 'prednisolone', 'tacrolimus'], 'is_context_needed': True}] |
The vinca alkaloid , vinorelbine , and the multi-targeted antifol , pemetrexed , were additive with imexon in both cell lines . | [{'class': 'POS', 'spans': ['vinorelbine', 'pemetrexed', 'imexon'], 'is_context_needed': False}] |
Supine blood pressures ( group means ) were 171/97 ( placebo ) , 147/85 ( enalapril ) , 154/84 ( atenolol ) and 144/78 ( enalapril plus atenolol ) ( S.E.M. + /- 2/+/- 1-ANOVA ) , and standing blood pressures were 170/105 ( placebo ) , 146/92 ( enalapril ) , 154/92 ( atenolol ) and 147/86 ( enalapril plus atenolol ) ( S.E.M. + /- 3/+/- 1 ) . | [{'class': 'POS', 'spans': ['enalapril', 'atenolol'], 'is_context_needed': False}] |
To evaluate the toxicity and activity of infusional fluorouracil ( FU ) , folinic acid ( FA ) , and oxaliplatin , administered every 2 weeks in patients with metastatic gastric cancer . | [{'class': 'POS', 'spans': ['fluorouracil', 'folinic acid', 'oxaliplatin'], 'is_context_needed': True}] |
Bevacizumab in combination with interferon alfa is now approved for treatment-naïve advanced renal cell carcinoma ( RCC ) in both the US and Europe . | [{'class': 'POS', 'spans': ['Bevacizumab', 'interferon alfa'], 'is_context_needed': False}] |
YM155 in combination with rituximab was tolerable with encouraging antitumor activity and durable responses in relapsed aggressive B-cell NHL patients . | [{'class': 'POS', 'spans': ['YM155', 'rituximab'], 'is_context_needed': False}] |
Similarly , a significant benefit in progression-free survival for carboplatin plus gemcitabine versus carboplatin monotherapy was seen in the Gynecologic Cancer InterGroup trial . | [{'class': 'POS', 'spans': ['carboplatin', 'gemcitabine'], 'is_context_needed': False}] |
We report a case series of 10 patients that were treated with betamethasone valerate foam ( 0.12 % ) in the morning and topical tazarotene cream ( 0.1 % ) in the evening for a total of 12 weeks or until plaques cleared . | [{'class': 'POS', 'spans': ['betamethasone', 'tazarotene'], 'is_context_needed': True}] |
Valsartan and sulfasalazine also reduced markers of oxidative stress after DSS administration . | [{'class': 'POS', 'spans': ['Valsartan', 'sulfasalazine'], 'is_context_needed': False}] |
Metronomic 5-fluorouracil , oxaliplatin and irinotecan in colorectal cancer . | [{'class': 'COMB', 'spans': ['5-fluorouracil', 'oxaliplatin', 'irinotecan'], 'is_context_needed': True}] |
Combination of mefloquine and praziquantel gave better curative effects than praziquantel or mefloquine given alone . | [{'class': 'POS', 'spans': ['mefloquine', 'praziquantel'], 'is_context_needed': False}] |
The aim of this study was to evaluate whether trastuzumab modifies the pharmacokinetics of epirubicin and its metabolites . | [{'class': 'COMB', 'spans': ['trastuzumab', 'epirubicin'], 'is_context_needed': True}] |
Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial . | [{'class': 'POS', 'spans': ['doxorubicin', 'cyclophosphamide', 'paclitaxel'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 2, 3], 'is_context_needed': True}] |
Bupropion differentially alters the aversive , locomotor and rewarding properties of nicotine in CD-1 mice . | [{'class': 'POS', 'spans': ['Bupropion', 'nicotine'], 'is_context_needed': False}] |
The first trial was a multicenter randomized phase III study of chemotherapy ( doxorubicin/cyclophosphamide or paclitaxel ) + /- trastuzumab , and the second was a multicenter phase II trial of vinorelbine + trastuzumab . | [{'class': 'COMB', 'spans': ['doxorubicin/cyclophosphamide', 'trastuzumab'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4], 'is_context_needed': True}] |
Peginterferon alfa-2a ( 40KD ) plus ribavirin has given an overall sustained virological response of 18 % in F3/F4 previous nonresponder US patients . | [{'class': 'POS', 'spans': ['Peginterferon alfa-2a', 'ribavirin'], 'is_context_needed': False}] |
We conducted a phase I and pharmacokinetic study with the erlotinib and celecoxib combination in patients with advanced premalignant lesions . | [{'class': 'POS', 'spans': ['erlotinib', 'celecoxib'], 'is_context_needed': True}] |
[ Efficacy of combination therapy of lamivudine and adefovir dipivoxyl for patients with hepatitis B-induced decompensated liver cirrhosis ] . | [{'class': 'POS', 'spans': ['lamivudine', 'adefovir'], 'is_context_needed': True}] |
The effervescent aspirin preparation is at least as effective as the combination of aspirin plus metoclopramide , but has fewer side effects . | [{'class': 'COMB', 'spans': ['aspirin', 'metoclopramide'], 'is_context_needed': True}] |
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