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ameloblastic fibroma ( af ) is an extremely rare true mixed benign tumor that can occur either in the mandible or maxilla .
it is frequently found in the posterior region of the mandible , often associated with an unerupted tooth .
it usually occurs in the first two decades of life with a slight female predilection... | ameloblastic fibroma is a rare odontogenic tumor comprising neoplastic epithelial and mesenchymal tissues .
this lesion was previously considered to be a benign lesion with very limited recurrence rate and malignant transformation .
however , recent reports have suggested that this lesion has the potential for recu... |
the burden of non - communicable disease in the developing countries is increasing and leading to high mortality rates . nowadays , type 2 diabetes ( t2 dm ) is pandemic and there are no signs of reduction in incidence rates .
diabetes is one of the most important risk factors for cardiovascular diseases and is the m... | metabolic syndrome is highly prevalent in type 2 diabetics and is a strong risk factor for cardiovascular diseases in such patients .
the aim of this study was to determine the prevalence of metabolic syndrome according to the three criteria of atpiii , idf and the new criteria for metabolic syndrome diagnosis in ker... |
insulin resistance is a classic risk factor for the development of type 2 diabetes mellitus ( t2 dm ) . a significant predisposition to insulin resistance
obesity and its associated comorbidities are reaching never - seen - before levels worldwide . with sufficient increases in basal and nutrient - stimulated insulin... | the worldwide prevalence of obesity is steadily increasing , nearly doubling between 1980 and 2008 .
obesity is often associated with insulin resistance , a major risk factor for type 2 diabetes mellitus ( t2 dm ) : a costly chronic disease and serious public health problem .
the underlying cause of t2 dm is a fail... |
overactivation of post - synaptic receptors for glutamate places a metabolic stress upon neurons which can contribute to neuronal injury in a wide range of conditions .
the evidence for a contribution of glutamate receptor overactivation ( termed excitotoxicity ) is strongest in conditions like ischemia , prolonged... | since the discovery and molecular characterization of ca2 + -permeable ampa channels just over two decades ago , a large body of evidence has accumulated implicating contributions of these unusual glutamate activated channels to selective neurodegeneration in certain conditions , including ischemia and amyotrophic late... |
transdermal delivery of nonsteroidal anti - inflammatory drugs is a topical treatment routinely used in physiotherapy to reduce pain and inflammation in musculoskeletal disorders.14 in order to weaken the skin barrier and to achieve a clinically effective drug concentration in the target tissues , various transdermal e... | aimthere is scarce information concerning the pharmacodynamic behavior of topical substances used in the physiotherapy setting .
the aim of the present study was to estimate the formation and emptying of the diclofenac ( df ) skin reservoir after passive , semiocclusive , and electrically assisted applications of df.... |
the primary hosts of this parasite are birds such as herons or ducks , and its second intermediate hosts are freshwater fish such as carp , crucian carp , or loach .
the parasite becomes a metacercaria inside the second intermediate host by forming a globular film around its body and waits for an opportunity to infec... | abstracta 64-year - old japanese man visited our outpatient department complaining of an irritable sensation in the throat , occurring two days after eating raw freshwater fish ( carp sashimi ) at a japanese - style inn . during laryngeal endoscopy , a slow - moving worm ( fluke )
was found attached to the surface of... |
it is common in countries with poor socio - sanitary conditions.1 humans act as intermediate hosts and get infected either through contact with definitive host ( dogs , wolves ) or its feces or by ingesting the infected food.2 due to its subtle presentation and absence of characteristic findings in plain radiographs , ... | we present a long term followup ( 13 years ) of spinal hydatid disease with multiple recurrences and intradural dissemination of the disease at the last followup .
intradural extension of the disease in our case was supposedly through the dural rent which has not been reported in english literature .
an early follo... |
acute myeloid leukemia ( aml ) is a clonal hematopoietic disorder characterized by uncontrolled self - renewal of hematopoietic stem cells , maturation arrest at myeloblast level , peripheral blood and bone marrow infiltration of blast cells .
it is demonstrated that pathogenesis of aml is associated with some disord... | abstractintoduction : acute myeloid leukemia ( aml ) is a heterogeneous group of hematologic malignancies with abundant changeability in the pathogenesis .
dna methylation of cpg islands within the promoters of specific genes may play roles in tumor initiation and progression.secreted frizzled - related proteins ( sf... |
this prospective study was conducted among 488 patients admitted to oncology ward of our hospital , over a period of 1 year , after obtaining the approval of the institutional ethics committee ( iec 176/2012 ) .
it was an observational , focused pharmacovigilance study carried out as a part of the pharmacovigilance p... | objectives : the aim of the study was to analyze the adverse drug reaction ( adr ) profile of microtubule - damaging antineoplastic drugs ( taxanes and vinca alkaloids ) and to look for unexpected adrs among the local population .
focused study on these drugs , rampantly used in oncology department for a wide variety... |
ultrasound is increasingly being applied in practical medicine for both clinical diagnosis and therapeutic purposes.1 , 2 for diagnostic applications , a better resolution of the morphological features of organs is desirable .
one of the most important factors in such diagnostic applications is the avoidance of biolo... | abstractdna doublestrand breaks ( dsbs ) caused by ultrasound were evaluated in a quantitative manner by singlemolecule fluorescence microscopy .
we compared the effect of timeinterval ( or pulse ) sonication to that of continuous wave ( cw ) sonication at a fixed frequency of 30 khz .
pulses caused fewer dsbs tha... |
as a result of increased access to dental care , people are retaining their natural dentition to a greater age . nevertheless , the prevalence of edentulism remains significant , especially among the elderly.1 the population continues to age worldwide , especially in developing countries and among groups with high soci... | aimdenture - related stomatitis is a disorder that often affects denture wearers .
the purpose of this study was to evaluate the intensity , genera , and frequency of yeasts in the oral cavity of complete denture wearers in terms of subject gender and age.materials and methodsnine hundred twenty patients ( 307 males ... |
the study subjects were type 2 diabetic patients enrolled in the diabetes management through an integrated delivery system ( dmids ) project ( nct00288678 , clinicaltrials.gov ) ( 6 ) .
the patient recruitment period was between august 2003 and december 2005 , with the project carried out through december 2009 .
al... | objectivean association between insulin resistance and microalbuminuria in type 2 diabetes has often been found in cross - sectional studies .
we aimed to reassess this relationship in a prospective taiwanese cohort of type 2 diabetic subjects.research design and methodswe enrolled 738 normoalbuminuric type 2 diabeti... |
schizophrenia and related psychoses are chronic disorders with an onset usually in early adulthood that affect patients all over their life and generally have moderate prognosis .
several previous [ 1 , 2 ] and more recent [ 3 , 4 ] studies have suggested that early intervention is crucial for the improvement of the ... | this is the first greek study presenting epidemiologic data on first - episode psychosis ( fep ) patients in a defined catchment area .
data for first episode psychotic patients during a two - year period ( 2008 and 2009 ) were obtained by all the mental health providers in the area , public or private .
a total of... |
a new thermodynamic model for calculating the dissociation constants of complexes formed between the aryl hydrocarbon receptor ( ahr ) and polychlorinated biphenyls ( pcbs ) is reported .
the free energies of binding of pcbs to ahr are controlled by their lipophilicities , electron affinities , and entropies .
the ... | |
if i wish to explain it to him who asks me , i do not know .
an initial issue regarding time is that , in our western mode of thinking , we have retained heracleitus ' metaphor of time being a river which we never can enter twice , because it never remains the same .
this is one the main assertions or principles at... | we are unable , using our five senses , to feel time , nor , using our intelligence , to define it , because we stand inexorably within time .
we achieve a representation of time through evaluation of changes in ourselves and in our environment .
this is made possible by memory functions .
what if time only exist... |
current comprehensive cancer care is centered on reducing the bulk of disease through surgery , chemotherapy , and radiation . despite the increasing effectiveness of these cornerstones of treatment and high cure rates of multiple cancer forms
, cancer remains a leading cause of death.1 recent breakthroughs in cancer... | recent us food and drug administration approvals of provenge ( sipuleucel - t ) as the first cell - based cancer therapeutic factor and ipilimumab ( yervoy/anticytotoxic t - lymphocyte antigen-4 ) as the first checkpoint blocker highlight recent advances in cancer immunotherapy .
positive results of the clinical tr... |
the morphologically similar appearing clear cells are ambiguous in nature and believed to be originated from different cell lineages such as epithelial , mesenchymal , melanocytic , or hematopoietic .
clear cell odontogenic carcinoma ( ccoc ) is one among the rare neoplasm with only 74 reported cases in the literarur... | clear cell odontogenic carcinoma is a rare , aggressive neoplasm of the jaw with only 74 reported cases .
it occurs predominantly in the mandibular anterior region during fifth to seventh decades of life .
clinically it manifests as intra - bony swelling with a variable degree of pain .
microscopically , it revea... |
whole blood viscosity ( wbv ) is one of virchow 's triad , which is an established concept of three phenomena including stasis , endothelial dysfunction and atherothrombosis that ultimately lead to , and/or result from cardiovascular complications[14 ] .
each phenomenon represents a subclinical vascular process , whi... | background : anticoagulant and antiplatelet therapies are being used interchangeably or in combination .
while international normalized ratio is assessed to determine anticoagulant 's contraindication / need , whole blood viscosity is not assessed to determine the need for antiplatelet.aims:the objective of this stud... |
the most frequent tumors and simulating lesions in ocular adnexa are lymphoproliferative disorders ( lpds ) , including malignant lymphomas and orbital inflammation with lymphoid hyperplasia or infiltration , some of which are historically called orbital pseudotumors . in japanese studies , goto reported that the r... | the most frequent ocular adnexal tumors and simulating lesions are lymphoproliferative disorders ( lpds ) , including malignant lymphomas and orbital inflammation with lymphoid hyperplasia or infiltration .
igg4-related orbital inflammation ( igg4-roi ) often involves lacrimal glands and other orbital tissues and is ... |
bone metastases affect up to two - thirds of patients with advanced solid tumours such as breast , prostate or lung cancer , and osteolytic bone lesions are typical of multiple myeloma .
individuals with bone metastases or lesions are at a high risk of experiencing skeletal - related events ( sres ) , including patho... | backgroundskeletal - related events ( sres ; pathologic fracture [ pf ] , spinal cord compression and radiation or surgery to bone ) are common complications of bone metastases or bone lesions and can impose a considerable burden on patients and healthcare systems . in this study ,
the healthcare resource utilisation... |
hemangiopericytomas ( hpcs ) were first categorized by stout as malignant tumors arising from the blood vessels and described as a sarcoma .
the cell of origin is thought to be the pericyte which interacts with endothelial cells and is critical for blood vessel maintenance .
hpcs are extremely rare and occur usuall... | hemangiopericytoma ( hpc ) is a rare sarcomatous tumor arising from pericytes , a support cell found in blood vessels .
these tumors can occur throughout the body , particularly in the lower extremities and retroperitoneum . in rare circumstances ,
hpcs can arise from the meninges . in these cases ,
they behave s... |
due to the nature of the job , physical therapists provide medical services in close
relationships with patients1 , 2 .
the turnover of physical therapists is a major loss in
quality improvement of health services and rehabilitation related to human resources3 .
currently , medical services are moving from heal... | [ purpose ] this study was conducted to provide basic data for solutions to reduce the
turnover rate of physical therapists .
it should help create efficient personnel and
organization management by exploring the impact of the work environment and work - related
stress on turnover intention and analyzing the co... |
one of the important risks is the existence of high levels of gasoline vapors including benzene that during work shifts employees are exposed to .
employees in functional units are more vulnerable population because of their continuous contact with harmful substances such as benzene .
based on usepa ( united state ... | background : reliable methods are crucial to cope with uncertainties in the risk analysis process .
the aim of this study is to develop an integrated approach to assessing risks of benzene in the petrochemical plant that produces benzene .
we offer an integrated system to contribute imprecise variables into the hea... |
type i ifns can be produced by almost any cell type in the body in response to stimulation of an array of transmembrane and cytosolic receptors .
in most cell types , the prevalent pathway of type i ifn induction is the activation of cytosolic receptors that recognize viral or other xenogeneic or autologous nucleic a... | although the role of type i interferon ( ifn ) in the protection against viral infections has been known and studied for decades , its role in other immunologically relevant scenarios , including bacterial infections , shock , autoimmunity , and cancer , is less well defined and potentially much more complicated . |
in gynecology endosalpingiosis is a benign condition in which fallopian tube - like epithelium is found outside of the fallopian tube .
endosalpingiosis is associated with the formation of psammoma bodies , which may lead to the misdiagnosis of malignancy such as serous carcinoma.1 the significance of endosalpingiosi... | in gynecology , endosalpingiosis is a benign condition in which the fallopian tube - like epithelium is found outside the fallopian tube .
the thirty - four point five percent of endosalpingiosis cases have concurrent endometriosis and 40% of the endosalpingiosis group are in postmenopausal states .
in contrast wit... |
breast cancer is the most common cancer diagnosed in women worldwide . in the united states the estimates for 2010 were 209,060 new cases of invasive breast cancer and 40,230 deaths .
the overall 5-year relative survival of patients with metastatic breast cancer is 23% , while the relative survival of breast cancer p... | metastasis is an extremely complex process that accounts for most cancer - related deaths .
malignant primary tumors can be removed surgically , but the cells that migrate , invade , and proliferate at distant organs are often the cells that prove most difficult to target therapeutically . there is growing evidence t... |
lumbar spondylolysis , a defect in the pars interarticularis , is a common cause of low back pain in adolescents and young adults .
it occurs in 6% of the general population and has been reported more commonly in men .
spondylolysis commonly occurs at the fourth and fifth lumbar vertebrae , accounting for more than... | abstractthree - level lumbar spondylolyses are extremely rare .
so far , only 11 cases were reported in the literature .
treatment of multilevel spondylolyses has not been consistent .
conservative treatment is commonly considered first in most patients , but those who remain symptomatic may benefit from operativ... |
angina bullosa hemorrhagica is a rare benign subepithelial oral mucosal blisters filled with blood that are not attributable to a systemic disorder or haemostatic defect .
angina bullosa hemorrhagica ( abh ) is a sub epithelial oral mucosal hemorrhagic blister of unknown aetiology .
this condition was first describ... | angina bullosa hemorrhagica ( abh ) is a disorder of unclear aetiology characterized by abrupt and unprovoked presentation of blood - filled blister over the oral mucosa .
histopathology reveals sub epithelial blister containing erythrocytes with superficial perivascular lymphocytic infiltrate .
we report two cases... |
congenital epulis , the rare benign soft - tissue tumors , derived from greek word meaning on the gum present with an aggressive appearance with large size , causing swelling , and difficulties during the breastfeeding . any exophytic , asymptomatic soft - tissue tumor in infants , unifocal / multifocal of the mucogi... | congenital soft - tissue tumors of oral cavity are mostly hyperplastic and benign in nature .
this article presents an unusual case of congenital subcutaneous hamartoma of incisive papilla in a 2-year - old female child causing feeding and breathing difficulty .
total excisional biopsy was done under local anesthes... |
systemic lupus erythematosus ( sle ) is a prototypic autoimmune disease affecting various parts of the body including skin , kidneys , lungs , joints , heart , nervous system , and hematopoietic organs .
it is a disease whereby a diverse array of autoantibody production , complement activation , immune complex deposi... | polymorphisms in genes involved in toll - like receptor / interferon signalling pathways have been reported previously to be associated with sle in many populations .
this study aimed to investigate the role of seven single nucleotide polymorphisms within tnfaip3 , stat4 , and irf5 , which are involved in upstream an... |
ultrasound is widely available in emergency departments and point - of - care ultrasound is increasingly used by emergency physicians .
detection of intraperitoneal free air ( ifa ) is of great value in identifying life - threatening conditions in patients with acute abdominal pain .
ifa usually occurs as a result ... | detection of intraperitoneal free air is important for the diagnosing of life - threatening conditions in patients with acute abdominal pain .
point - of - care ultrasound is an extension of the clinical examination in patients presenting with acute abdomen .
failure of sonographers to detect intraperitoneal free a... |
there is still no evidence to base interventions on neuropsychological rehabilitation or cognitive stimulation related with learning development .
this is not derived at all from a lack of studies but to methodological difficulties finding trials suitable for meta - analysis .
this is a real hazard for translationa... | introductionthere is still no evidence to base interventions on neuropsychological rehabilitation or cognitive stimulation related with learning development .
there are two main problems to solve .
the first is the sustainability of the clinical interventions .
the second one is the lack of evidence .
this is n... |
acute hospital settings do not provide the ideal care environment for older patients with heart failure ( hf ) .
a european integrated home - care model has been developed with the goals that patients will experience participation , safety and have knowledge about their disease and treatment .
to describe the meani... | introductionacute hospital settings do not provide the ideal care environment for older patients with heart failure ( hf ) .
an option is to provide advanced hf care in the patient s home .
a european integrated home - care model has been developed with the goals that patients will experience participation , safety... |
brain and other central nervous system ( cns ) cancers include a variety of histopathologic subtypes , but the most common , by far , are gliomas . these tumours , which arise from the glial cells that surround and support neurons , include astrocytoma , glioblastoma , oligodendroglioma , oligoastrocytoma , and ependym... | mtor / s6k pathway is a crucial regulator of cell growth and metabolism .
deregulated signalling via s6k has been linked to various human pathologies , including metabolic disorders and cancer .
many of the molecules signalling upstream of s6k have been shown to be either mutated or overexpressed in tumours , leadi... |
since its discovery in the mid-1960s , the development of stable ,
well - defined , and functional - group - tolerant olefin metathesis catalysts
has greatly influenced the fields of organic synthesis and polymer
and materials science .
although alkene metathesis has
found a wide range of applications , alkyn... | the pseudo - octahedral
molybdenum benzylidyne complex [ tolcmo(ono)(or)]kor ( r = cch3(cf3)2 ) 1 , featuring a stabilizing ono pincer ligand , initiates
the controlled living polymerization of strained dibenzocyclooctynes
at t > 60 c to give high molecular weight
polymers
with exceptionally low polydispersit... |
conjugated polymers
have been studied extensively because of their
semiconducting and optical properties , which offer great potential
for a diverse range of applications such
as organic light - emitting diodes , field - effect
transistors , and polymer solar cells .
recently , macrocycles have attracted in... | conjugated
polymers with cyclic structures are interesting because
their symmetry leads to unique electronic properties .
recent advances
in vernier templating now allow large shape - persistent fully conjugated
porphyrin nanorings to be synthesized , exhibiting unique electronic
properties .
we examine t... |
with the evolution of radical prostatectomy from an open technique to a laparoscopic or robotic approach , several discussions have ensued regarding the anatomy around the posterior bladder neck ( bn ) , because the antegrade dissection proceeds differently in the new approaches from that used in the open approach [ 1 ... | purposeto evaluate the impact of a retrotrigonal layer backup stitch ( rtbs ) during robot - assisted laparoscopic radical prostatectomy ( ralp ) on post - prostatectomy incontinence.materials and methodswe compared the difference in continence recovery between 94 patients ( group 1 , as historical controls ) and 57 pa... |
postoperative as are well described major and long - term complications of cervical laminoplasty for csm .
the overall incidence ranges from 6% to 60% 1,2 . the incidence and severity of as appears to vary among different types of laminoplasty procedures .
further , various procedural approaches to the cervical spi... | study design : retrospective cohortobjective : to determine if there are differences in important clinical outcomes between patients treated with a preservation of the unilateral posterior muscular - ligament complex ( pmlc ) procedure and a hinge side anchoring procedure ( hsap ) for the treatment of cervical sp... |
caricom countries like many other developing nations are in varying stages of an epidemiologic and nutrition transition , such that the traditional public health problems of infectious disease have decreased in prevalence , only to be largely replaced by the diseases of life style that are associated with western - t... | previous reviews of nutritional status in children under 5 years describe the caribbean grouped with latin america .
this paper focuses specifically on the caribbean and the goals and targets of the millennium declaration that have bearing on childhood development .
the results indicate that caricom countries have ... |
copd is a lifestyle - related disease of the lungs that is primarily caused by regular smoking.1 it is an inflammatory disease associated with damage to the alveolar septa and increased levels of inflammatory mediators , such as c - reactive protein ( crp ) , interleukin-6 , interleukin-1 , and tumor necrosis factor- (... | purposecopd is mainly caused by tobacco smoking and is associated with a high frequency of coronary artery disease .
there is growing recognition that the inflammation in copd is not only confined to the lungs but also involves the systemic circulation and can impact nonpulmonary organs , including blood vessels .
... |
craniopharyngioma is a type of benign tumor that arises from rathke s pouch , a derivative of the oral ectoderm , and accounts for approximately 33.5% of all intracranial tumors3 ) .
although regarded as a world health organization ( who ) grade i tumor , it often demonstrates aggressive local behavior after surgery ... | craniopharyngiomas exhibiting histologic malignancy are extremely rare .
herein , we report the case of a 26-year - old male patient who underwent suprasellar mass excision via an interhemispheric transcallosal approach .
histopathological examination indicated that the craniopharyngioma was of the adamantinomatous... |
since the initial evidence for the existence of transposable elements ( tes ) reported by mcclintock , large - scale sequencing of the genome of a wide range of living organisms has highlighted the abundance of te - derived sequences relative to the coding portion of genomes .
parasitic dna , are mobile genetic elem... | sequences related to transposons constitute a large fraction of extant genomes , but insertions within coding sequences have generally not been tolerated during evolution .
thanks to their unique nuclear dimorphism and to their original mechanism of programmed dna elimination from their somatic nucleus ( macronucleus... |
primary sclerosing cholangitis ( psc ) and primary biliary cirrhosis ( pbc ) are both immune - mediated chronic cholestatic liver conditions .
psc , which is frequently seen in association with inflammatory bowel disease , is a chronic biliary disease which may affect both the intra- and extrahepatic biliary tree whi... | background / aim .
sulphotransferase 2a1 ( sult2a1 ) exerts hepatoprotective effects .
transcription of sult2a1 gene is induced by pregnane - x - receptor ( pxr ) and can be repressed by mir-378a-5p .
we studied the pxr / sult2a1 axis in chronic cholestatic conditions : primary sclerosing cholangitis ( psc ) and ... |
it is estimated that , globally , 466,000 new cases of cervical cancer are diagnosed
each year . as per estimate 231,000 women in a year
die of cervical cancer and 80% of them are from the developing world .
use of cytological screening technique , papanicolaou ( pap ) test , has significantly increased the detec... | the majority of squamous cell carcinomas of cervix are preceded by visible changes in the cervix , most often detected by cervical smear . as cervical cancer is preceded by long precancerous stages , identification of the high - risk population through detection of dna ploidy may be of importance in effective managemen... |
early life events contribute substantially to the likelihood of an individual becoming obese , although underlying mechanisms are not well understood .
obesity in women of reproductive age ( 15 to 44 years ) is increasing rapidly , and up to 50% of women in this age range in the usa are now either overweight or obese... | objective . offspring born to mothers either fed an obesogenic diet throughout their life or restricted to pregnancy and lactation demonstrate obesity , hyperinsulinemia , and hyperleptinemia , irrespective of their postweaning diet .
we examined whether timing of a maternal obesogenic diet results in differential re... |
diabetes is a major threat to public health worldwide , and its prevalence has rapidly increased and even has influenced the younger population .
the world health organization estimates that about 366 million people worldwide will develop diabetes by 2030 , the majority of who develop type 2 diabetes ( t2d ) .
life... | background : organic cation transporter 3 ( oct3 ) is an excellent transporter for metformin , which is used as first - line therapy for type 2 diabetes ( t2d ) .
oct3 genetic variants may influence the clinical response to metformin .
this study aimed to determine the genotype and allele frequency of oct3 - 564g >... |
halogenated inhalational anesthetics are the most commonly used agents for induction and maintenance of general anesthesia .
the choice of anesthetic depends on many factors including ease of administration , cost , availability and permissibility of their effects . for more than 50 years
chloroform the original ha... | context : halogenated inhalational anesthetics are currently the most common drugs used for the induction and maintenance of general anesthesia . postoperative hepatic injury has been reported after exposure to these agents .
based on much evidence , mechanism of liver toxicity is more likely to be immunoallergic .
... |
the most prevalent cause of pelvic floor muscle dysfunction in females is the attenuation
of the pelvic floor muscle , resulting in a state in which the pelvic floor muscle is unable
to be independently recognized and contracted .
this results in pelvic girdle relaxation ,
pelvic organ prolapse , or stress urin... | [ purpose ] the purpose of this study was to verify the efficacy of a pelvic floor muscle
exercise program by comparing subjects muscle thickness with changes in vaginal pressure .
[ subjects ] two groups of female participants without a medical history of pelvic floor
muscle dysfunction were evaluated .
the me... |
helminths employ a range of immunomodulatory strategies to modulate the host immune response and utilize it to extend their longevity in the host and facilitate transmission .
characteristic of infection with helminths such as schistosoma mansoni is the induction of a th2 response .
two products released from egg... | we have shown that schistosoma mansoni egg soluble antigen ( sea ) prevents diabetes in the nonobese diabetic ( nod ) mouse inducing functional changes in antigen presenting cells ( apcs ) and expanding t helper ( th ) 2 and regulatory t cell ( treg ) responses . a th2 response to s. mansoni infection or its antigens i... |
diabetic high blood glucose or hyperglycemia causes mortality and morbidity through dn and dr via disrupting the vascular function in the kidney and retina .
these pathologies are the major cause of death associated with renal failure and blindness among the type 1 and type 2 diabetes patients [ 13 ] .
similar mole... | diabetic nephropathy ( dn ) and diabetic retinopathy ( dr ) are major complications of type 1 and type 2 diabetes .
dn and dr are mainly caused by injury to the perivascular supporting cells , the mesangial cells within the glomerulus , and the pericytes in the retina .
the genes and molecular mechanisms predisposi... |
adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract with an incidence of about 0.1% to 0.2% .
age - adjusted incidence of cancer of the appendix is 0.12 cases per 1 000 000 per year .
these rare tumors are seldom suspected before surgery , and < 1/2 are diagnosed intraoperative... | adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract that most commonly presents as right lower abdominal pain , mimicking acute appendicitis .
presentation caused by loco - regional spread with involvement of adjacent structures is rare .
an accurate and complete preoperative d... |
bronchogenic cysts are not uncommon in either children or adults . in children , they comprise approximately 6% of all mediastinal masses . their presentation can range from an asymptomatic incidental finding to sudden respiratory distress .
video - assisted thoracoscopy was utilized to remove a bronchogenic cyst tha... | background : bronchogenic cysts are not uncommon in either children or adults . in children , they comprise approximately 6% of all mediastinal masses .
their presentation can range from an asymptomatic incidental finding to sudden respiratory distress.case report : video - assisted thoracoscopy was utilized to remov... |
in recent years , medical anthropologists have been turning their ethnographic attention to issues of science and technology , including how science is produced , where it is produced , by whom , and when .
anthropologists have also highlighted how scientific and technological advancements spread around the world , g... | medical anthropological research on science , biotechnology , and religion has focused on the local moral worlds of men and women as they make difficult decisions regarding their health and the beginnings and endings of human life .
this paper focuses on the local moral worlds of infertile muslims as they attempt t... |
rna interference ( rnai ) is a conserved cellular mechanism by which a small double stranded rna ( dsrna ) directs the degradation of complementary mrna and therefore inhibits the expression of a specific gene.(1 ) since its discovery , rnai has become a powerful tool to study gene functions in biological processes .
... | a key challenge for therapeutic application of rna interference is to efficiently deliver synthetic small interfering rnas ( sirnas ) into target cells that will lead to the knockdown of the target transcript ( functional sirna delivery ) . to facilitate rational development of nonviral carriers ,
we have investigate... |
to study mitochondrial nuclear genetic interactions in the nematode caenorhabditis briggsae , our three laboratories independently created 38 intra - species cytoplasmic nuclear hybrid ( cybrid ) lines .
although the cross design combines maternal mitotypes with paternal nuclear genotypes , eight lines ( 21% ) unex... | |
simple anthropometric measures of body composition and fat distribution are widely accepted as being the most practical and valuable approach to diagnose excess body fat , usually classified as overweight and obesity .
excess body fat can have an adverse effect on health , leading to development of various chronic di... | summarybackgroundanthropometric measures of body composition and arterial stiffness are commonly used as indicators of cardiovascular risk .
little is known , however , about the association of the anthropometric measures with arterial stiffness , especially in a healthy , generally non - obese population.material/me... |
subjects : this research was performed within the framework of the ( dpp ) diabetes prevention project , in isfahan , iran .
our aim in dpp was to prevent diabetes by some lifestyle measure or even medication interventions among at risk individuals ( ifg / igt patients ) . in the dpp ,
the first group was the lifes... | background : antropometric measures with biochemical indicators have been used as screening tools for metabolic abnormalities in adolescents and adults .
a few studies have assessed the relation of ewet ( enlarge waist elevated triglyceride ) phenotype with diabetes , especially among individuals with first relative ... |
the evolution of sexually dimorphic traits , such as armaments , bright coloration , or exaggerated traits has long been of interest to evolutionary biologists , as such traits are often thought to reduce fitness through natural selection ( e.g. , ) .
however , in spite of the potential negative consequences of the... | traits involved in sexual signaling are ubiquitous among animals .
although a single trait appears sufficient to convey information , many sexually dimorphic species exhibit multiple sexual signals , which may be costly to signalers and receivers .
given that one signal may be enough , there are many microevolution... |
seasonal affective disorder ( sad ) was first time described as syndrome of recurrent episodes of depression that occur annually ( usually in winter season at same time each year ) by rosenthal et al . in 1984 .
diagnostic and statistical manual of mental disorders , 4 edition , text revision ( dsm - iv - tr ) descri... | background : many therapeutic options have been evaluated and tried for seasonal affective disorder ( sad ) including bright light therapy ( blt ) , anti - depressants , beta - blockers and psychotherapy , but the data supporting use of mood - stabilizing agents is just handful in spite of this condition being understo... |
in patients presenting with their first seizure , identifiable structural brain abnormalities are a risk factor for recurrent seizure and imaging helps guide clinicians in determining whether or not to recommend the initiation of chronic treatment with antiepileptic drugs ( aeds ) after an initial seizure .
the epide... | in hiv - positive individuals with first seizure , we describe neuroimaging findings , detail clinical and demographic risk factors for imaging abnormalities , and evaluate the relationship between imaging abnormalities and seizure recurrence to determine if imaging abnormalities predict recurrent seizures . among 43 p... |
renal cell carcinoma ( rcc ) is among the most frequent malignant tumors with significant morbidity and mortality .
more than 58,000 estimated new cases and more than 13,000 deaths occurred in the united states in 2010 . during the last decades , an increase in the incidence of all clinical stages of renal tumors was... | purpose to evaluate the oncological outcomes , complications , and changes in renal function in patients treated with computed tomography - guided percutaneous radiofrequency ablation ( rfa ) for small renal tumors.materials and methodsthe charts of patients who underwent rfa from 2006 to 2011 at a single institution w... |
anti - n - methyl - d - aspartate receptor ( anti - nmdar ) encephalitis is an increasingly recognized etiology of previously unexplained encephalopathy and encephalitis , since its original description in 2007 , .
the disease has initially been described in women with an ovarian teratoma but can also be seen in seen... | since its original description in 2007 , anti - n - methyl - d - aspartate receptor ( anti - nmdar ) encephalitis associated with an ovarian teratoma is an increasingly recognized etiology of previously unexplained encephalopathy and encephalitis .
extreme delta brush ( edb ) is a novel electroencephalogram ( eeg ) f... |
the european committee for standardization defines bitumen as a virtually nonvolatile , adhesive , and waterproofing dark brown viscous organic material derived from crude oil or present in natural asphalt . due to its binding and hydrophobic properties
, bitumen is commonly used for the construction of pavements and... | over the recent years , bitumen modification with polymers , acids , or mineral fillers has gained relevance to adjust its performance properties .
this work reports the use of polyphosphoric acid ( ppa ) for the modification of formulated bitumen . with this objective ,
an in - depth literature review on ppa modif... |
when a crime is committed and a biological trace such as blood stain or semen is found at the crime scene or the body of the victim , forensic scientists can link the case to the arrested suspect through the matching of the trace evidence to the suspect , using dna profiling . for cases in which no suspect can be ident... | the role of familial database search as a crime - solving tool has been increasingly recognized by forensic scientists . as an enhancement to the existing familial search approach on single source cases ,
this article presents our current progress in exploring the potential use of familial search to mixture cases .
... |
human diseases can be treated by the transfer of therapeutic genes ( transgene ) into specific cells or tissues of patients to correct or supplement defective , causative genes .
the success of gene therapy depends on the ability to deliver therapeutic dna or sirna or other genetic materials to target site .
viral ... | 50 kda chitosan was conjugated with folate , a specific tissue - targeting ligand .
nanoparticles such as chitosan - dna and folate - chitosan - dna were prepared by coacervation process .
the hydrodynamic intravenous injection of nanoparticles was performed in the right posterior paw in normal and arthritic rats ... |
contrast media can lead to acute deterioration in renal function particularly in patients with pre - existing chronic kidney disease .
about 1214% of patients who develop acute renal sufficiency during hospitalization do so after procedures involving radiographic contrast
. the incidence of progressive deterioratio... | contrast media administration can lead to acute deterioration in renal function particularly in patients with pre - existing chronic kidney disease .
this prospective , randomized controlled open - label parallel group study was undertaken at nizam 's institute of medical sciences , hyderabad , from june to december ... |
h2o2 , an endogenous oxidant present in all aerobic cells , was traditionally viewed as a toxic substance ( winterbourn , 2008 ) .
however , research during the last two decades built a compelling case supporting the role of h2o2 as a diffusible signaling messenger that controls many cellular processes by modulating ... | a challenge in the redox field is the elucidation of the molecular mechanisms , by which h2o2 mediates signal transduction in cells .
this is relevant since redox pathways are disturbed in some pathologies .
the transcription factor oxyr is the h2o2 sensor in bacteria , whereas cys - based peroxidases are involved ... |
a 33-year - old woman was admitted to our hospital with a two - month history of abdominal distension and edema . the patient had no prior history of drug usage , including oral contraceptives , and no relevant family medical history . upon admission ,
the patient underwent a physical examination , which revealed dif... | we report an extremely rare case of a diffuse hepatic hemangiomatosis without extrahepatic involvement in an adult .
the imaging findings of this tumor were similar to those of a hepatic hemangioma and included contrast enhancement with a centripetal filling pattern of the entire hepatic tumor on the delayed phase of... |
ectopic neurohypophysis may be accompanied by midline brain defects and some degree of endocrine disorders .
the associated endocrine disease varies from isolated growth hormone ( gh ) deficiency to multiple anterior pituitary hormone deficiencies , but posterior pituitary function remains unchanged .
anterior pitu... | ectopic neurohypophysis is a pituitary gland abnormality , which can accompany growth hormone deficiency associated with dwarfism .
here we present magnetic resonance imaging ( mri ) findings of a rare case of ectopic neurohypophysis , corpus callosum dysgenesis , and periventricular neuronal heterotopia coexisting ,... |
there are an estimated 150,000 surgical amputations per year in the us , most of which are secondary in nature , arising from diabetes mellitus , vascular disease , trauma , and cancer.1 residual pain in amputation stumps can extend beyond the normal recovery time , and is seen in 13%71% of cases.2,3 after the nerve in... | debilitating stump pain following amputation surgery is a major problem when it affects the patient s quality of life , often making the patient totally dependent on others for their day - to - day care .
attempts have been made to treat those patients through pharmacological , psychological , and physical therapies ... |
in excess of one billion people are infected with helminths in developing countries , where these diseases cause substantial morbidity and hundreds of thousands of deaths annually ( may , 2007 ; albonico et al . , 2008 ; hotez , 2011 ; bardosh , 2014 )
. helminths also plague livestock in developing and developed co... | infection with helminth parasites causes morbidity and mortality in billions of people and livestock worldwide . where anthelmintic drugs are available , drug resistance is a major problem in livestock parasites , and a looming threat to public health . monitoring the efficacy of these medicines and screening for new d... |
bacteria and archaea exist in an incessant arms race with various selfish genetic elements ( phages , transposons , and plasmids ) and have evolved a variety of defense systems .
the best known ones probably are the numerous restriction - modification enzyme systems that exploit different methylation patterns of host... | most of the archaea and numerous bacteria possess an elaborate system of adaptive immunity to mobile genetic elements known as the crispr ( clustered regularly interspaced short palindromic repeats)-associated system ( crispr - cas ) , which consists of arrays of short repeats interspersed with unique dna spacers and a... |
ductal carcinoma in situ ( dcis ) increases the risk for developing contralateral breast cancer ( cbc).1 the risk for developing either invasive cancer or dcis in the contralateral breast has been estimated at 0.6% per year.1,2 increasing numbers of women with dcis are electing contralateral prophylactic mastectomy ( c... | the authors retrospectively examined the contralateral prophylactic mastectomy ( cpm ) rate among 100 women with ductal carcinoma in situ who are brca negative .
of 100 women with ductal carcinoma in situ , 31 elected contralateral prophylactic mastectomy ( cpm ) .
factors associated with increased likelihood of un... |
according to popular studies , the attempted resuscitation of patients in traumatic cardiac arrest in the prehospital care environment should not be pursued due to undo risk to the provider and has been shown to be ineffective . however , after review of current literature , sherren and colleagues developed and publish... | traumatic cardiac arrest resuscitation is considered a heroic and futile endeavor . however , newer articles have more promising statistics and divide between prehospital ground and helicopter transport . here
we discuss why there might be a difference in the survivability of this subset of trauma patients . |
following advances in information - tailoring tools and telemedicine , medical information becomes increasingly available and individuals take a more active role in managing their personal health . at the same time , the environment in which patients consume medical and health information has changed dramatically .
t... | background : following the entrance of new technologies in health information era , this study aimed to assess changes in health information sources of iranian people during past decade.methods:totally 3000 people were asked about their main sources of health information .
they were selected as two community - based ... |
like in other branches of medicine , in psychiatry too , most clinicians and researchers are concerned , if not really obsessed , with what is the most recent advance in a particular field or area .
enlightened readers scan the references list and are suitably impressed if there is a generous sprinkling of recent one... | most clinicians and researchers are concerned with recent advances in psychiatry .
this involves the danger whether something time - tested may get sidelined for extra - scientific reasons .
that the pharmaceutical industry and superspecialist researcher may keep churning out new findings to impress audiences is on... |
a 29-year - old woman , being artificially inseminated with twins , was hospitalized to get a cesarean section .
a cesarean section was scheduled for her on the next day , but sudden pain and progression of the childbirth delivery forced her to the childbirth delivery room early . as she had undergone a vaginal deliv... | meralgia paresthetica is commonly caused by a focal entrapment of lateral femoral cuteneous nerve while it passes the inguinal ligament .
common symptoms are paresthesias and numbness of the upper lateral thigh area .
pregnancy , tight cloths , obesity , position of surgery and the tumor in the retroperitoneal spac... |
a large number of patients suffer from sciatica , low back , and postoperative pain , treating which is one of the most important topics for clinicians in orthopedic surgery or anesthesiology .
nonsteroidal anti - inflammatory drugs ( nsaids ) have been commonly used but are effective only for treating inflammatory p... | backgroundadenosine is an endogenous neuromodulator in both the peripheral and central nervous systems .
adenosine inhibits pain signals by hyperpolarizing neuronal membrane.methodsto clarify the effects of adenosine on pain signals , we tested intrathecal adenosine injection in two neuropathic pains ( spinal cord co... |
the phenomenon of
immigration has an immense impact on the health care of population in the united states .
cases of tuberculosis ( tb ) among foreign - born nationals , currently living in
the united states , account for more than half of the total .
also the absence of systemic symptoms does not rule out tb .... | background . with the world becoming a global village ,
tuberculosis is no longer limited to endemic areas .
our case emphasizes the impact of immigration on infectious disease epidemiology and challenges associated with diagnosis and treatment in pregnancy . case .
a 21-year - old hispanic female presented in pr... |
core stabilization exercises may prevent or improve
symptoms of low back pain because it provides the basis for force production by the
limbs2 .
broad benefits of core
stabilization have been reported , including improvement of athletic performance and
prevention of injuries3 .
the core muscles include the ... | [ purpose ] the aim of the present study was to identify the effects of an unstable support
surface ( uss ) on the activities of trunk and lower extremity muscles during pulley - based
shoulder exercise ( pbse ) . [ subjects ] twenty healthy college students were included in this
study .
[ methods ] surface emg... |
data prospectively collected in the canadian alteplase for stroke effectiveness study ( cases ) were analyzed ( 16 ) .
this was a national prospective cohort study that led to the full approval of iv - tpa for acute ischemic stroke in canada .
sixty sites across the country participated over a period of 2.5 years a... | objectiveadmission hyperglycemia has been associated with worse outcomes in ischemic stroke .
we hypothesized that hyperglycemia ( glucose > 8.0
mmol / l ) in the hyperacute phase would be independently associated with increased mortality , symptomatic intracerebral hemorrhage ( sich ) , and poor functional status ... |
in a retrospective observational study recently published in british medical journal , lockey et al . note that trauma patients intubated without sedation before reaching hospital had a poor prognosis .
they looked at the records of 1623 patients registered in a helicopter emergency medical service database over si... | endotracheal intubation is widely used for airway management in a prehospital setting , despite a lack of controlled trials demonstrating a positive effect on survival or neurological outcome in adult patients .
the benefits , in term of outcomes of invasive airway management before reaching hospital , remain controv... |
a 62-year - old female presented with gradually increasing swelling of the right side face for 5-years duration .
extra orally she had a diffuse , bony hard , non - tender swelling involving right side mandible ( expansion of ramus , angle , and posterior body region ) [ figure 1a ] . color and texture of the overlyi... | granular cell ameloblastoma is a rare variant of ameloblastoma , which is histopathologically characterized by the presence of large eosinophilic granular cells within the ameloblastic follicle .
its accurate preoperative diagnosis is based upon clinical , radiological , and incisional biopsy findings .
this articl... |
cardiovascular disease ( cvd ) including sudden cardiac death ( scd ) is a major cause of mortality in chronic kidney disease ( ckd ) .
apart from left ventricular dysfunction , unique factors such as autonomic imbalance and inflammation contribute to the high incidence of scd in ckd .
traditional risk factors fo... | sudden cardiac death and atherosclerosis have a major impact on cardiovascular mortality in chronic kidney disease ( ckd ) .
inflammation with elevated high - sensitive c - reactive protein ( hs - crp ) is involved in both sudden cardiac death and atherosclerosis , and decreased heart rate variability ( hrv ) is a pr... |
it is generally established that the harmful effects of communicable disease and malnutrition on public health are of the utmost importance notably in the poor countries .
consequently , the priority of the health institutions and care workers has been focusing on control and preventive measures of the infectious dis... | background : a school - based surveillance system entitled the childhood and adolescence surveillance and prevention of adult noncommunicable disease ( caspian ) study is implemented at national level in iran .
this paper presents the methods and primary findings of the third survey of this surveillance system.method... |
the effectiveness of endodontic files , rotary instrumentation , irrigating solutions , and chelating agents to clean , shape , and disinfect root canals underpins the success , longevity , and reliability of modern endodontic treatments .
the role of microorganisms in the development and perpetuation of pulp and per... | sodium hypochloride is the most commonly used endodontic irrigant , despite limitations .
none of the presently available root canal irrigants satisfy the requirements of ideal root canal irrigant .
newer root canal irrigants are studied for potential replacement of sodium hypochloride .
this article reviews the ... |
recently , helper - dependent adenoviral vectors ( hdads ) have been used to deliver donor dna into human embryonic stem cells ( escs ) , induced pluripotent stem cells ( ipscs ) , and adult stem cells to achieve high efficiency gene editing by homologous recombination to a wide variety of transcriptionally active and ... | helper - dependent adenoviral vectors mediate high efficiency gene editing in induced pluripotent stem cells without needing a designer nuclease thereby avoiding off - target cleavage . because of their large cloning capacity of 37 kb , helper - dependent adenoviral vectors with
long homology arms are used for gene ... |
effective occupational safety and health ( osh ) management requires appropriate and reliable osh performance measurement .
an indicator can be defined as a concise definition of a concept , meant to provide maximal information on an area of interest,[1 , p.36 ] or a quantitative or qualitative factor or variable t... | improvement of occupational safety and health ( osh ) management is closely related to the development of osh performance measurement , which should include osh outcomes ( e.g. , occupational accidents ) , osh inputs ( including working conditions ) and osh - related activities .
the indicators used to measure the os... |
polymer
nanocomposites that integrate nanoparticles ( nps ) into
polymer melts often possess superior mechanical , thermal , optical ,
or electrical properties in comparison with pure polymeric materials .
fabrication and processing of polymer nanocomposites
require a good understanding of their viscoelastic ... | the motion of nanoparticles
( nps ) in entangled melts of linear
polymers and nonconcatenated ring polymers are compared by large - scale
molecular dynamics simulations .
the comparison provides a paradigm
for the effects of polymer architecture on the dynamical coupling
between nps and polymers in nanocomp... |
micrornas ( mirnas ) are small endogenous post - transcriptional regulators of gene expression found in a wide range of eukaryotes .
these 20- to 24-nucleotide ( nt)-long rnas regulate numerous physiological processes , including cell proliferation , differentiation , apoptosis and development [ 25 ] .
deregulation... | the human genome contains more than 1,000 microrna ( mirna ) genes , which are transcribed mainly by rna polymerase ii .
the canonical pathway of mirna biogenesis includes the nuclear processing of primary transcripts ( pri - mirnas ) by the ribonuclease drosha and further cytoplasmic processing of pre - mirnas by th... |
atonic seizures are characterized by a sudden loss or diminution of muscle tone without an apparent preceding myoclonic or tonic event .
this phenomenon was first described as a postepileptic paralytic phenomenon and is now well known as todd 's paralysis .
currently , such an episode of atonia during an epileptic ... | a focal atonic seizure is a partial seizure in which the ictal manifestation consists of paresis of the extremities or muscles on one side of the body , and this phenomenon can easily be misdiagnosed as a transient ischemic attack .
an 86-year - old woman visited our hospital complaining of transient right upper extr... |
inflammatory activation with increased serum cytokine levels has been described by several authors as an important factor in the progression of the syndrome of chronic heart failure ( chf ) [ 13 ] . in multifactorial analyses ,
elevated levels of tumour necrosis factor-(tnf- ) alpha and interleukin-(il- ) 6 have been... | background . we pooled data from four studies , to establish whether exercise training programs were able to modulate systemic cytokine levels of tumour necrosis factor - alpha ( tnf - alpha ) and interleukin-6 ( il-6 ) .
a second aim was to establish if differences in ext regimens are related to degree of change in ... |
understanding the cellular and molecular basis of nociception is a challenge that has important implications for pain management and the development of new analgesics .
nociception plays a vital role in the survival of the organism , serving to transmit warning signals of impending harm.13 however , beyond this funct... | backgroundpulsed radiofrequency energy ( prfe ) fields are being used increasingly for the treatment of pain arising from dermal trauma . however , despite their increased use , little is known about the biological and molecular mechanism(s ) responsible for prfe - mediated analgesia . in general , current therapeutics... |
kimura 's disease is a rare benign haematological disorder , involving subcutaneous tissue , predominantly in the head and neck region and frequently associated with painless lymphadenopathies .
the disease is endemic in asia , but rare and sporadic in the rest of the world .
it can be associated with eosinophilia ... | we report the case of a young caucasian man presenting with diffuse oedema and nephrotic syndrome .
clinical examination revealed multiple lymphadenopathies .
histological examination was consistent with the diagnosis of kimura 's disease .
a renal biopsy showed focal segmental glomerulosclerosis .
immune throm... |
an increasing number of proteins with unknown function have their 3d structure solved at high resolution ( 1 ) .
this situation , largely due to structural genomics initiatives ( 2 ) , has been stimulating the development of automated structure - based function prediction methods ( 3 ) .
knowledge of residues impor... | better characterization of binding sites in proteins and the ability to accurately predict their location and energetic properties are major challenges which , if addressed , would have many valuable practical applications .
unfortunately , reliable benchmark datasets of binding sites in proteins are still sorely lac... |
vertebral artery injury is a catastrophic complication that can occur during anterior decompression of the cervical foramen .
the distance between the uncinate tip and the vertebral artery was found to be as short as 1 mm on cadaveric specimens.1
2 there are controversies regarding the width of the uncinate proces... | study design computed tomography based cohort study .
objective although there are publications concerning the relationship between the vertebral artery and uncinate process , there is no practical guide detailing the dimensions of this region to use during decompression of the intervertebral foramen .
the purpo... |
urethral catheterization is one of the most commonly performed procedures in healthcare settings worldwide , with more than 5 million urinary catheterization in the united states in the year 2000 alone ( 1 ) . adding to this , it is usually safe and relatively easy if performed by well - trained healthcare personnel . ... | since urethral foley catheterization is usually easy and safe , serious complications related to this procedure have been rarely reported .
herein , we describe a case of intraperitoneally placed urethral catheter via verumontanum presenting as intraperitoneal bladder perforation in a chronically debilitated elderly ... |
traditional bone setters ( tbs ) have been with us for a very long time and they still enjoy patronage by all categories of people , ranging from the uneducated to the very highly educated group in the society . there is a general belief in most african communities that tbs are better at fracture treatment than orthodo... | aims and objectives : the objectives of this study were to analyze the different reasons why patients with fractures patronize traditional bone setters ( tbs ) and their impression of the outcome of the treatment by the tbs.materials and methods : a 24 month prospective observational study was conducted from february 2... |
spontaneous intracerebral hemorrhage ( s - ich ) accounts for 10% to 15% of all strokes and 78% to 88% of intracerebral hemorrhages24 ) .
the 30-day mortality rate of s - ich has been reported to range from 35% to 52%24 ) , and around half of all deaths occur during the first 2 days3 ) .
in addition , s - ich produ... | objectivethe aim of this study was to determine 30-day mortality and 6-month functional recovery rates in spontaneous intracerebral hemorrhage ( s - ich ) patients undergoing hemodialysis treatment for end - stage renal disease ( esrd ) , and to compare the outcomes of these patients and s - ich patients without esrd.m... |
g - protein
coupled receptors ( gpcrs ) are located in the cellular
membrane and act as mediators for cell signaling , making them promising
therapeutic targets . however , drug design for gpcrs has been challenging
due to the paucity of validated 3d structures .
although these integral
membrane proteins ha... | human
cannabinoid type 1 ( cb1 ) g - protein coupled receptor is a
potential therapeutic target for obesity .
the previously predicted
and experimentally validated ensemble of ligand - free conformations
of cb1 [ scott , c. e. et al .
protein sci.2013 , 22 , 10111323184890 ; ahn , k. h. et al .
proteins20... |
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