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obesity increases the risk for hypertension and is a major driver of morbidity and mortality due to cardiovascular diseases ( dustan , 1983 ; poirier et al . , 2006 ) .
studies in rodents with diet - induced obesity ( dio ) suggest that increased sympathetic nerve activity ( sna ) is an important mediator of obesity... | summaryobesity is associated with increased blood pressure ( bp ) , which in turn increases the risk of cardiovascular diseases .
we found that the increase in leptin levels seen in diet - induced obesity ( dio ) drives an increase in bp in rodents , an effect that was not seen in animals deficient in leptin or lepti... |
hydrogen peroxide - inducible clone 5 or hic-5 is a gene we isolated by subtractive hybridization in 1994 as a cdna clone induced by transforming growth factor ( tgf- ) or hydrogen peroxide . at that time
, we studied tgf- signalling and pursued the possibility that reactive oxygen species ( ros ) function was an in... | hic-5 is a multidomain lim protein homologous to paxillin that serves as a molecular scaffold at focal adhesions and in the nucleus .
it forms mobile molecular units with lim - only proteins , pinch , and crp2 and translocates in and out of the nucleus via a nuclear export signal ( nes ) . of note , nes of hic-5
is... |
numerous systems have been proposed to classify thoracolumbar injuries . among the most influential were the ideas proposed by denis , magerl / ao , and the thoracolumbar injury classification system ( tlics).1
2
3 the denis system was valuable in providing a modern concept of spinal stability and integrating the f... | study design survey of 100 worldwide spine surgeons .
objective to develop a spine injury score for the aospine thoracolumbar spine injury classification system .
methods each respondent was asked to numerically grade the severity of each variable of the aospine thoracolumbar spine injury classification system .... |
autoimmune diseases ( ads ) are a family of more than 80 chronic , and often disabling , illnesses broadly characterized by immune system dysfunction leading to the loss of tolerance to self - antigens , presence of increased level of autoantibodies , inflammatory and mediatory cells and resulting chronic inflammation ... | human genetic diversity is the result of population genetic forces .
this genetic variation influences disease risk and contributes to health disparities . autoimmune diseases ( ads )
are a family of complex heterogeneous disorders with similar underlying mechanisms characterized by immune responses against self . ... |
diabetes mellitus is a syndrome characterized by chronic hyperglycemia and disturbances of carbohydrate , fat , and protein metabolism occurs due to deficiency of insulin ( type 1 ) or insensitivity of the target tissues to insulin ( type 2 ) . when untreated , it leads to multiorgan damage , specially cardiovascular ,... | context : diabetes mellitus is a chronic metabolic disorder of endocrinal origin with multiorgan involement . today 's physician has a lot many options to choose for treating type 2 diabetes , but does not always manages to achieve optimal glycemic control .
the newer drug bromocriptine acts by novel hypothalamic cir... |
a 17-year - old male patient visited our institution with a complaint of a painful movable mass on the lateral distal aspect of the right femur that was not caused by trauma .
the mass had been slowly growing for 6 months and started to cause increasing pain from one month ago .
a firm and movable mass with a size ... | ganglion cysts are common lesions that are most often found around the joints of the hands and feet .
ganglia around the distal femur usually occur within the synovial membrane or tendon sheath , but rarely within muscles .
several cases of intramuscular ganglions in the hand and wrist have been reported , but a ga... |
measuring efficiency has been common in a large range of activities , including health care ( 1 , 2 ) , insurance services ( 3 ) , universities ( 4 , 5 ) , and research activities ( 6 ) . analyzing efficiency through dea ( data envelopment analysis ) is an assessment of output - input ratio in order to find relative ef... | introductionefficiency analysis is necessary in order to avoid waste of materials , energy , effort , money , and time during scientific research .
therefore , analyzing efficiency of knowledge production in health areas is necessary , especially for developing and in - transition countries . as the first step in thi... |
lymphoscintigraphies performed during sentinel lymph node ( sln ) mapping and biopsies in breast cancer have discovered lymphatic extra - axillary drainage in 20 - 27% of cases .
extra - axillary nodes most often located are : ipsilateral internal mammary chain ( imc ) ( 17% ) , intra - mammary ( 3% ) , supraclavicul... | lymphatic drainage outside the ipsilateral axilla in breast cancer is discovered in as many as 25% of all sentinel lymph node procedures and it is evidenced by lymphoscintigraphy .
contralateral axillary drainage is a rare clinical situation , mostly if there is not prior breast surgery , but this situation is extrem... |
in the daily lives of most modern people , the time spent working with the neck bent
forward , working on a computer , riding in cars , and engaging in leisure activities while in
a sitting positions has been increasing .
this sitting causes overloads in the soft tissues
that support the neck , and repeated dam... | [ purpose ] the purpose of the present study was to examine the effects of longus colli
muscle massage on the strength and endurance of the deep neck flexor muscle in adults .
[ subjects ] a total of 60 subjects were divided into an experimental group of 30 subjects
and a control group of 30 subjects .
[ method... |
bacterial strains , growth conditions , and the peptide : b. abortus biotype 1 isolate from korean cattle was used for the
construction of a vaccine by means of gi24 .
b. abortus strain rb51 served as the comparative vaccine ( versus the vaccine candidate ) .
b.
abortus strain 544 ( atcc 23448)smooth , virulent... | brucella abortus cells were lysed by the n - terminal 24-amino acid fragment ( gi24 ) of the 36-amino acid peptide pmap-36 ( porcine myeloid
antimicrobial peptide 36 ) .
next , the protection efficacy of the lysed fragment as a vaccine candidate was evaluated .
group a mice were immunized with sterile
pbs , gro... |
we studied 2 outbreaks of orally transmitted chagas disease ( 120 cases , 5 deaths ) .
the first occurred in chichiriviche , vargas state , a coastal community ( population 800 persons ) 50 km northwest of caracas , venezuela .
the outbreak occurred at a primary school where food was prepared on site . in early apr... | oral outbreaks of chagas disease are increasingly reported in latin america .
the transitory presence of trypanosoma cruzi parasites within contaminated foods , and the rapid consumption of those foods , precludes precise identification of outbreak origin .
we report source attribution for 2 peri - urban oral ou... |
alzheimer s disease ( ad ) is a complex neurodegenerative disease , which can be divided into two major forms : early - onset ad ( eoad ) and late - onset ad ( load ) with dividing age of 65 years , respectively .
three dominant causative genes for eoad are amyloid precursor protein ( app ) , presenilin-1 ( psen1 ) ,... | a 49-year - old korean male patient with dementia was diagnosed with probable early - onset alzheimer s disease ( ad ) .
he presented with memory problems , personality changes , and disorientation .
his family history of dementia was probably negative , since no family member with dementia was found or mentioned .... |
the vitreous humor ( volume of ~4 ml in an adult ) comprises the majority of the eye s volume1 and is responsible for several visually debilitating conditions such as retinal tear and detachment , macular hole , macular pucker , and vitreomacular traction ( vmt ) .
the vitreous has a uniform gel - like consistency at... | backgroundvitreous degeneration begins soon after birth and accelerates throughout life .
vitreous liquefaction with a slowly progressive separation of the posterior hyaloid from the peripheral macula usually leads to complete posterior vitreous detachment .
the purpose of this study is to measure the age - related... |
a 56-year - old man presented with a 12-month history of tingling ulcers on both feet ( figure 1a ) .
he was otherwise well . on examination there were ulcers on both feet , 11.5 cm in diameter with a macerated edge .
skin - colored to red - brown papules were noted on both knees ( figure 1b ) as well as irregular ... | a 56-year - old man presented with tingling ulcers on the feet . on further skin examination , papules on the knees were observed .
biopsies revealed extravascular eosinophilic deposits of igm , and waldenstrm macroglobulinaemia was diagnosed .
the skin manifestations have resolved with chemotherapy .
peripheral ... |
taehwa , danyang - gun , chungcheongbuk - do , korea ( n 3707'01.42 '' , e 12829'05.11 '' ) .
healthy leaves were collected from conifer species growing at the site , including 3 juniper trees ( juniperus rigida siebold et zucc . ) , 4 japanese larch trees [ larix kaempferi ( lamb . ) carr . ] , and 5 pine trees ( pi... | the needled leaves of three conifer species were collected in mt .
taehwa during different seasons of the year .
total 59 isolates and 19 species of endophytic fungi were isolated from the leaves and identified using morphological and molecular characteristics . as a result ,
shannon index was different in its ho... |
convincing evidence continues to emerge from clinical trials that gene therapy is
yielding therapeutic effects in patients suffering from a wide range of
diseases .
in particular , liver - directed gene therapy is
becoming a promising modality to obtain sustained hepatocyte - specific expression
of secreted f... | the robustness and safety of liver - directed gene therapy can be substantially
improved by enhancing expression of the therapeutic transgene in the liver . to
achieve this
, we developed a new approach of rational in silico vector
design .
this approach relies on a genome - wide bio - informatics strategy to... |
overweight and obesity in children are increasing in prevalence in both developing and developed countries ( 1 ) . abdominal obesity and insulin resistance
mets is a combination of disorders that increase the risk of cardiovascular disease and diabetes ( 2 ) .
in contrast to adults ; conflicting results were found ... | background : epicardial fat has a role in cardiovascular diseases.objectives:to assess epicardial fat and its relation with carotid intima - media thickness ( imt ) in obese adolescents with metabolic syndrome ( mets).patients and methods : the study included 60 obese adolescents and 25 control subjects . according to ... |
phosphate - based cathartic agents can be bought over the counter ( otc ) as remedial for constipation .
it is widely prescribed for colon preparation before any form of intra - abdominal surgery or colonoscopy .
we report a 49-year - old female who had a history of end - stage renal failure secondary to iga glomer... | oral sodium phosphate ( osp ) , an effective bowel purgative , is available over the counter ( otc ) and requires a substantially lower volume than polyethylene glycol - based preparative agents . rarely , osp consumption has been associated with acute hypocalcemia and hyperphosphatemia .
we describe a case of chroni... |
the goals of surgical treatment for thoracolumbar burst fractures are to restore vertebral column stability and to decompress neural elements4 ) . due to several problems associated with extensive long - level instrumentation ,
posterior short - segment instrumentation has been recently preferred for the treatment of... | objectivethe purpose of this study was to compare the results of three types of short segment screw fixation for thoracolumbar burst fracture accompanying osteopenia.methodsthe records of 70 patients who underwent short segment screw fixation for a thoracolumbar burst fracture accompanying osteopenia ( -2.5 < mean t sc... |
the traditional approach to drug discovery involves de novo identification and validation of new molecular entities ( nme ) , which is a time - consuming and costly process . despite huge investment in drug discovery and development and explosive advancement in biological / informational technologies during past decade... | drug repositioning ( also referred to as drug repurposing ) , the process of finding new uses of existing drugs , has been gaining popularity in recent years .
the availability of several established clinical drug libraries and rapid advances in disease biology , genomics and bioinformatics has accelerated the pace o... |
six percent of the world population is affected by diabetes mellitus ( dm ) which is a chronic metabolic disorder .
the who defines diabetes mellitus as a metabolic disorder of multiple aetiology characterized by chronic hyperglycemia with disturbances of carbohydrate , fat and protein metabolism resulting from defe... | introduction : diabetes mellitus is on alarming rise in india .
drug utilization studies help to identify the adherence to standard treatment guidelines and to evaluate the rational drug usage.objective:to study prescription pattern , calculate the cost of antidiabetic drugs and to evaluate the adherence to treatment... |
a male neonate weighing 3.9 kg who exhibited whole body cyanosis and desaturation upon birth was diagnosed with dextro - transposition of the great arteries , atrial septal defect , and patent ductus arteriosus associated with a single coronary artery pattern .
the leiden classification is often used in clinical cont... | an eight - day - old neonate was diagnosed with dextro - transposition of the great arteries , atrial septal defect , patent ductus arteriosus , and a single sinus origin of the coronary arteries .
the single coronary artery originated from the left sinus ( sinus 2 ) , had a proximal left circumflex arterial branch ,... |
although the exact embryological mechanism for this condition remains unclear , it is thought to relate to a disruption of development of the lateral folds of rathke during hindgut development.1 several anatomical variants have been described , and the classification system proposed by effman , lebowitz , and colodny h... | duplication of the urethra is a rare congenital anomaly , with approximately 300 cases reported in the literature .
we report a unique case of this condition in a male infant .
this case differs from the classical effman type ii - a2 duplication because of the presence of two hypospadic urethral meati , as opposed ... |
the ageing process is accompanied by an increased prevalence of the signs and symptoms of physical fragility , including sarcopenia , a decrease in exercise tolerance , osteopenia , an increase in visceral adiposity and a worsening of quality of life .
adults with growth hormone deficiency ( ghd ) exhibit similar cli... | growth hormone ( gh ) use has been speculated to improve physical capacity in subjects without gh deficiency ( ghd ) through stimulation of collagen synthesis in the tendon and skeletal muscle , which leads to better exercise training and increased muscle strength . in this context , the use of gh in healthy elderly sh... |
squamous cell carcinoma ( scc ) is a common malignancy , and cutaneous scc accounts for up to 20% of non - melanoma skin cancers in the united states , making it the second most common skin cancer .
other primary sites of scc are locations where squamous epithelium is normally found , including the lung , oropharynx ... | metastatic squamous cell carcinoma ( scc ) involving the gastrointestinal tract as the sole site of metastatic disease is exceedingly rare .
we report a patient with known cutaneous scc that metastasized to regional lymph nodes who , after therapy , appeared to be disease free until a small metastatic lesion was iden... |
giant cell tumor of the bone ( gctb ) is a benign bony tumor accounting for 5 to 8% of all bone tumors ; it is generally observed at the epiphysis of long bones .
it is rare before maturity , and it has a female predilection.1 the axial skeleton above the sacrum , especially the upper cervical spine , is an uncommon ... | study design case report .
objective the purpose of this work is to report the case of a giant cell tumor involving the second cervical vertebra in a pediatric patient .
surgical management included a combined posterior and anterior cervical approach .
there has been no recurrence in 2 years of follow - up .
... |
pedicle screw fixation is a necessary part of various spinal surgeries . despite many advantages of using pedicle screws , their usage in the spine is replete with danger and has the potential for permanent neurologic deficit , especially when placing screws near the spinal cord at the concave apex of a scoliotic spine... | objectiveto improve pedicle screw placement accuracy with minimal radiation and low cost , we developed specially designed k - wire with a marker . to evaluate the accuracy of thoracolumbar pedicle screws placed using the novel guide - pin and portable x-rays.methodsobservational cohort study with computerized tomograp... |
we identified 27 hips in 27 patients who underwent revision tha and showed metallosis from a catastrophic failure of a pe liner in their hip joints during revision tha among all the patients who underwent revision thas in seoul national university hospital between january 1996 and august 2004 .
three patients were lo... | backgroundwear can not be completely prevented after total hip arthroplasty .
if severe polyethylene ( pe ) liner wear develops , the so - called catastrophic failure occurs and metallosis develops .
we postulated that longevity of the new implant may be affected after revision surgery for metallosis following a ca... |
classic neuroimaging findings described in gm2 gangliosidosis is hyperdense signal in bilateral thalami in non - contrast computed tomography ( ncct ) scan and hypointensity in t2 weighted mri images .
hyperdens thalamus in ncct head in a child with neuroregrssion , facial dysmorphism and organomegaly , should lead u... | gm1gangliosidosis is a rare autosomal recessive lysosomal storage disorder caused by deficiency of enzyme -galactosidase , resulting in progressive neural and visceral accumulation of gm1gangliosides .
coarse facial features , bilateral cherry red spots , and dysostosis multiplex are important clue to diagnose this c... |
malignancy is a recognized complication of renal transplantation . in australia , it is estimated that 25% of all renal transplant recipients surviving for 20 years will develop a non - skin cancer .
renal cell carcinoma ( rcc ) accounted for 4.6% of de novo cancer in solid organ transplant recipients , but the major... | the increased risk of malignancies is a well - recognized complication of organ transplantation .
when renal cell carcinoma ( rcc ) occurs in kidney transplant recipients , less than 10% of it affects the allograft .
recent experience suggests that partial allograft nephrectomy for tumours less than 4 cm may be con... |
it is recognized that the growing epidemic of obesity is linked to a recent decline in physical activity levels .
socioeconomic changes have led to profound changes in individual 's lifestyle including the adoption of unhealthy food consumption patterns , prevalent tobacco use , alcohol abuse , and physical inactivit... | background : to assess and compare physical activity based on age , gender , marital status , education , and employment among dental health professionals in hyderabad city , india.materials and methods : a cross - sectional questionnaire study was conducted among dentists and they were personally interviewed by a sing... |
over the last few years , the involvement of the proteasome pathway in ligand - dependent nuclear receptor degradation has been established .
this pathway entails first a polyubiquitination of the substrate , catalyzed by three factors ( e1 , e2 and e3 ) , followed by its proteolysis by the proteasome .
recently , ... | in this perspective we consider new aspects of ligand - induced estrogen receptor ( er ) degradation .
what are the possible roles of csn5/jab1 and the csn complex in this process ?
we compare hormone ( estrogen ) or pure antagonist ( fulvestrant ) induced degradation of er and review the effects of kinase - inhib... |
in many countries , occupational accidents have impaired the health and safety of workers in various professions . in 1998 , france reported 1.35 million occupational accidents among 14.5 million workers , which was a 3% increase in the number of accidents reported in 1997 .
of these accidents , 52% caused injuries (... | background : electrical burns account for a significant percentage of fatal accidents .
each year , a number of consumers in iran suffer from electrical injuries due to technical problems , equipment failures , and the unauthorized use of electricity .
the aim of this study was to examine the root causes of acciden... |
extragonadal occurrence is rare , and it is usually found in the anterior mediastinum , retroperitoneum , and sacrococcygeal region .
primary retroperitoneal teratoma is unusual in patients above the age of 30 years ; only 10% have been reported to occur after that age .
teratomas confined to the adrenal gland are ... | background : teratoma is a germ - cell tumor that commonly affects the gonads .
its components originate in the ectoderm , endoderm , and mesoderm .
extragonadal occurrence is rare .
teratomas confined to the adrenal gland are exceptional ; only 3 cases have been reported in the english - language literature .
... |
non - lichenoid cutaneous reactions secondary to imatinib mesylate are the most common non - hematologic adverse reactions associated with its use.lichenoid drug eruption usually occurs on the photo - exposed parts of the skin .
non - lichenoid cutaneous reactions secondary to imatinib mesylate are the most common no... | imatinib mesylate ( i m ) , an anticancer drug , has been widely used to treat chronic myeloid leukemia ( cml ) , gastrointestinal stromal tumors ( gist ) , and dermato - fibrosarcoma protuberans .
cutaneous reactions to i m have been reported to occur in varying number of patients in different case series .
non - ... |
in older adults , performance of many habitual daily activities and tasks requires moving and controlling the center of gravity ( defined as the vertical projection of the center of mass ) to various positions within the base of support .
however , effective displacement of the center of gravity during either self - ... | backgroundlimits of stability , defined as the ability to maintain the center of gravity within the boundary of the base of support , is critically important for older adults in performing their activities of daily living .
however , few exercise programs specifically tailored to enhance limits of stability exist .
... |
this is in contrast to the regular cytotoxic chemotherapy drugs that either damage the deoxyribonucleic acid or inhibit the microtubules and kill or inhibit the rapidly dividing cancer cells .
maximum tolerated doses ( mtd ) of these drugs are designed to kill as many tumor cells as possible .
such doses require pr... | introduction : metronomic chemotherapy ( mc ) is a novel therapeutic variation for resistant cancers , wherein chemotherapeutic drugs are administrated in low doses with no prolonged drug - free break .
it lessens the level of toxicity , is better tolerated and enhances the quality of life .
this retrospective anal... |
humans ( indeed all biological multicellular organisms ) are made of multiscale hierarchy of structures ranging from subcellular structures ( 10 m ) to cells ( 10 m ) , basic functional units ( the smallest aggregation of diverse cells that behaves like the parent organ 10 m ) , organs ( 1010 m ) , and bodies ( 10 ... | the blood vessels and nerve trees consist of tubular objects interconnected into a complex tree- or web - like structure that has a range of structural scale 5 m diameter capillaries to 3 cm aorta .
this large - scale range presents two major problems ; one is just making the measurements , and the other is the exp... |
deep brain stimulation ( dbs ) is an effective treatment option for a number of neurological disorders , including movement disorders , pain , and epilepsy [ 14 ] . following dbs procedures ,
skin erosion and/or infection can occur , most commonly at the connector site [ 5 , 6 ] .
infection constitutes a serious ad... | infection constitutes a serious adverse event in patients submitted to deep brain stimulation , often leading to removal of the device .
we set to evaluate the potential role of immunoscintigraphy with 99mtc - labelled antigranulocyte antibody fragments ( 99mtc - sulesomab ) in the management of infection following d... |
the ability to grip is one of the most important functions of the hand , and grip strength can be used to reflect overall muscular strength .
several studies have shown that grip strength is inversely associated with all - cause mortality , functional impairments , frailty markers , cognitive impairments , physical d... | objectivesgrip strength has been used as a measure of function in various health - related conditions .
although grip strength is known to be affected by both physical and psychological factors , few studies have looked at those factors comprehensively in a population - based cohort regarding elderly koreans .
the ... |
asbestosis is one of the most frequently studied diseases associated with the inhalation of asbestos fibers .
the exposure to asbestos is known to cause inflammation , fibrous scarring in the lung , and cancer [ 1 , 2 ] .
it has been suggested that , in addition to reactive oxygen species ( ros ) , the reactive nit... | asbestos , a known occupational pollutant , may upregulate the activity of inducible nitric oxide synthase ( inos ) and thus the production of nitric oxide ( no ) .
this study investigated whether inos ( ccttt)n polymorphism is associated with an increased asbestosis risk in exposed workers .
the study cohort cons... |
we conducted a prospective , single - center observational study over 2 time periods ( july to november 2013 and february to april 2014 ) .
semistructured interviews were conducted with consecutive eligible acs patients admitted to a metropolitan tertiary hospital located in melbourne , australia .
the study was ap... | backgroundthe aim of this study was to examine the awareness of a recent mass media campaign , and its influence on knowledge and prehospital times , in a cohort of acute coronary syndrome ( acs ) patients admitted to an australian hospital.methods and resultswe conducted 199 semistructured interviews with consecutive ... |
congenital talipes equinovarus is recognized as the down and in foot , often resembling a club - like appearance .
it is the most important cause of physical disability among all congenital musculoskeletal defects occurring in an otherwise normal child.1 for many years , the kite 's method was used for the correcti... | background : gentle passive manipulation and casting by the ponseti method have become the preferred method of treatment of clubfoot presenting at an early age . however , very few studies are available in literature on the use of ponseti method in older children .
we conducted this study to find the efficacy of pons... |
this is because it can provide site - specific information about protein motions over a large range of time scales .
over the past decade , n nmr relaxation experiments employing model - free analysis ( 1,2 ) have become the de facto standard used to characterize protein motions on a picosecond to nanosecond time sca... | protein motions play important roles in numerous biological processes such as enzyme catalysis , muscle contractions , antigen antibody interactions , gene regulation and virus assembly .
knowledge of protein flexibility is also important in rational drug design , protein docking and protein engineering .
however ... |
parkinson s disease ( pd ) was first known as shaking palsy , a term coined in 1817 by james
parkinson .
it is a progressive neurologic disturbance in which the incidence rate increases
with age1 .
when approximately 6080% of the dopamine produced by the
substantia nigra dopaminergic neurons has been lost , t... | [ purpose ] the purpose of this study was to investigate the effect of muscle vibration in
the lower extremities in patients with parkinson s disease ( pd ) during walking .
[ subjects ]
nine patients with pd participated in this study and were tested with and without
vibration ( vibration at 60 hz ) .
[ met... |
radiation - induced sarcoma ( ris ) is a rare late event after radiation therapy ( rt ) , with a reported incidence of 0.03%- 0.2% in 5 years and overall up to 0.8% .
it is known to have a worse prognosis than sporadic soft tissue sarcoma ( sts ) , with a 5-year disease - specific survival ( dss ) rate of 32%-58% in ... | purposethe purpose of this study is to report on the incidence and the experience in management of radiation - induced sarcoma ( ris ) at a large single center in korea for 15 years.materials and methodswe retrospectively reviewed the sarcoma registry of a large institution from january 2000 to april 2014.resultsout of... |
procalcitonin ( pct ) is elevated in serum of patients with severe infections of bacterial or parasitic origin . increased levels
it has been recently demonstrated that pct levels in falciparum malaria correlate with parasitemia and disease severity , and that markedly elevated values ( > 25 ng / ml ) are associated ... | backgroundprocalcitonin ( pct ) is closely correlated with parasite burden and clinical outcome in falciparum malaria .
the role of pct in tertian malaria has not previously been investigated.patients and methodspct serum levels in 37 patients with tertian malaria were analysed .
clinical and laboratory parameters ... |
kohn sham ( ks )
density functional theory ( dft ) provides
a powerful theoretical framework for performing calculations on a
subsystem exactly embedded in its full , quantum - mechanical environment . the quantity that mediates the interaction between subsystems is
the electronic density , which is partitione... | density functional theory ( dft ) provides a formally exact
framework
for quantum embedding .
the appearance of nonadditive kinetic energy
contributions in this context poses significant challenges , but using
optimized effective potential ( oep ) methods , various groups have devised
dft - in - dft methods... |
nanoparticles are diverse class of small - scale ( < 100 nm ) substances with novel properties like small size , large surface area , specific shape , and surface activity .
toxicity of nanomaterials refers to the interaction of nanomaterials with the biological systems and induction of toxic responses .
once insi... | in this study , dextran coated ferrite nanoparticles ( dfnps ) of size < 25 nm were synthesized , characterized , and evaluated for cytotoxicity , immunotoxicity , and oxidative stress by in vitro and in vivo methods .
cytotoxicity was performed in vitro using splenocytes with different concentrations of dfnps .
g... |
after tooth extraction , the healing process initiates however , alveolar socket never reaches its previous dimensions either buccolingually or apicocoronally .
additionally , the remaining bone structure after healing undergoes a progressive resorption ( catabolic remodeling ) .
resorption in the first 6 months af... | statement of the problem : various researchers have suggested the use of 2-adrenergic receptor antagonists in prevention or treatment of bone resorption .
purpose : this study aimed to evaluate the effect of 2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extracti... |
esthetics can influence the selection of the prosthesis . in screw - retained implant restorations ,
the screw- access hole is unesthetic ; because the gray color of screw hole can not be eliminated by opaque composite materials .
all prostheses have inherent advantages and disadvantages ; clinicians should assess ... | screw - retained implant restorations have an advantage of predictable retention as well as retrievability , and obviate the risk of excessive sub - gingival cement commonly associated with cement retained implant restorations .
screw - retained restorations generally have screw access holes , which can compromise es... |
for a successful bacterial colonization of the oral cavity , adherence mechanisms are essential , otherwise the bacteria get washed away and swallowed by the salivary flow .
oral bacteria have evolved several mechanisms to withstand the salivary flow and succeed in adhesion to and subsequently form biofilm on surface... | previous studies demonstrated that a cranberry high - molecular - mass , nondialyzable material ( ndm ) can inhibit adhesion of numerous species of bacteria and prevents bacterial coaggregation of bacterial pairs .
bacterial coaggregation leads to plaque formation leading to biofilm development on surfaces of oral ca... |
alternative medicine refer to a broad set of health care practices that are not part of that country s own tradition or conventional medicine and are not fully integrated into the dominant health - care system . according to who they are used interchangeably with traditional medicine in some countries .
homeopathi... | some physicians have incorporated some forms of complementary and alternative medicine ( cam ) or related medicinal products in their clinical practices , suggesting that an unconventional treatment approach might be seen as an integration rather than as an alternative to standard medical practice . among the various c... |
samples : serum samples were taken from 337 pet rabbits presented to 34
veterinary facilities in different 20 prefectures in japan .
healthy rabbits were brought to the veterinary clinics for either general
health checks or other disease conditions . among the rabbits ,
the rest showed variable clinical
condi... | abstractthe potential contamination of toxoplasma gondii and
neospora caninum oocysts in the human environment is a concern from the
public health viewpoint .
however , estimation of their seroprevalences in humans can not be
performed in a manner that distinguishes between oocysts and tissue cysts as a source ... |
to investigate the role of the chinese herbal medicine xianhuayin on the reversal of 7,12-dimethylbenz[a]anthracene ( dmba)-induced premalignant mucosal lesions in the oral buccal pouch of golden hamsters .
the animals were randomly divided into a non - diseased control group ( n=5 ) and an experimental group includi... | aimto investigate the role of the chinese herbal medicine xianhuayin on the reversal of 7,12-dimethylbenz[a]anthracene ( dmba)-induced premalignant mucosal lesions in the oral buccal pouch of golden hamsters.methodologythe animals were randomly divided into a non - diseased control group ( n=5 ) and an experimental gro... |
streptococcus pneumoniae ( spn ) may cause a wide spectrum of diseases ranging from otitis and pneumonia to invasive forms such as meningitis or sepsis . among pneumococcal diseases , pneumonia has the higher clinical burden in terms of morbidity , mortality and hospitalization rate , with heavy implications for worldw... | pneumococcal pneumonia has a high clinical burden in terms of morbidity , mortality and hospitalization rate , with heavy implications for worldwide health systems .
in particular , higher incidence and mortality rates of community - acquired pneumonia ( cap ) cases , with related costs , are registered among elderly... |
extracorporeal membrane oxygenation ( ecmo ) , which can support gas exchange or hemodynamics in patients with severe respiratory or cardiac failure , has demonstrated considerable evolution over the last decade , with a steady rise since 2009 in the number of ecmotreated patients and number of centers providing ecmo s... | this article is one of ten reviews selected from the annual update in intensive care and emergency medicine 2017 .
other selected articles can be found online at http://ccforum.com/series/annualupdate2017 .
further information about the annual update in intensive care and emergency medicine is available from http:/... |
early reports of well - differentiated nonmedullary thyroid carcinoma clustering in families [ 17 ] , and studies utilizing population and hospital data bases [ 813 ] demonstrating that such cases occurred in families more often than could be explained by chance have led to the general acceptance of the existence of a ... | background . whether or not the familial form of papillary thyroid carcinoma is more aggressive than the sporadic form of the disease remains controversial . methods . to explore this question and whether or not increased aggressiveness is more apparent in families with multiple affected members , we performed a chi sq... |
it is the third - ranking cause of death , and therefore affects the health care system in thailand.1 one of the common consequences of stroke is spasticity .
it is defined as a motor disorder that is characterized by a velocity - dependent increase in tonic stretch reflexes ( muscle tone ) with exaggerated tendon je... | purposeto study the efficacy of traditional thai massage ( ttm ) versus conventional physical therapy ( pt ) programs in treating muscle spasticity , functional ability , anxiety , depression , and quality of life ( qol ) in thai stroke patients.methodsthis randomized controlled trial with a blinded assessor was carrie... |
it has been reported that stress and anxiety stimulate adrenal gland and sympathetic nervous system which , in a sophisticated process , leads to an increase in bp , respiratory irregularities , dyspnea , an increase in the rate of respiration and hearth rate , and in case of frequent prolonged exposure to chronic stre... | introduction : admission of a family member to hospital would cause stress on other family members also .
one of the most stressful treatment interventions imposing high level of anxiety to the families of patients is when the patients are undergoing a surgery , especially a cardiac surgery .
so , we decided to inv... |
twenty - one premature infants born between 30 and 34 wk ga with a birth weight > 1500 g were recruited for this study .
exclusion criteria included major chromosomal anomalies , intraventricular hemorrhage ( > grade ii ) , necrotizing enterocolitis , excessive drug / alcohol use , data missing regarding the date to ... | the objective of the study is to determine whether salivary foxp2 gene expression levels at the initiation of oral feeding attempts are predictive of oral feeding success in the premature newborn . in this prospective study , saliva samples from 21 premature infants ( 13 males ; birth gestational age [ ga ] : 3034 wk )... |
to report an effect of the full tendon transposition augmented with posterior intermuscular suture and recession - resection surgery , for the patient with monocular elevation deficiency ( med ) and large exotropia .
full tendon transposition augmented with posterior intermuscular suture and recession - resection sur... | purposeto report an effect of the full tendon transposition augmented with posterior intermuscular suture and recession - resection surgery , for the patient with monocular elevation deficiency ( med ) and large exotropia.methodsinterventional case report .
full tendon transposition augmented with posterior intermusc... |
during the last decades , governments across many jurisdictions have been faced by the challenge of controlling increasing health care expenditure , partly due to new medical technologies , within a context of dwindling budgets , exacerbated by the recent economic and financial crisis . as a result ,
demand for evide... | the use of health technology assessment ( hta ) to inform policy - making is established in most developed countries .
compared to licensing agencies , hta agencies have different interests and , therefore , different evidence requirements .
criteria for coverage or reimbursement decisions on pharmaceutical compoun... |
the brachial plexus supplies the upper extremity and is formed by the fusion of the anterior primary rami of the cervical ( c5 - 8 ) and the first thoracic ( t1 ) spinal nerves .
the five roots fuse to form three trunks which further branch into anterior and posterior divisions behind the clavicle .
these divisions... | the knowledge of innervation of pectoral muscles is important to surgeons performing breast surgeries , axillary lymph node dissection , harvesting pectoralis major / minor for flaps , and during neurotization procedures where the pectoral nerves are particularly at risk .
the present case describes the innervation o... |
meningioma has been known to be a common intracranial tumor , accounting for 13% to 19% of all primary brain tumors .
in contrast , extracranial meningioma are uncommon , and particularly those with extension into a middle ear .
especially , ear and temporal bone meningiomas have been reported to show a variety of ... | extracranial meningioma with extension into a middle ear is very uncommon .
a 74-year - old female was admitted to our hospital with right ear bleeding when removing earwax . in this case ,
magnetic resonance imaging , computed tomography , her past history and operative findings would consider as infiltrative grow... |
gold catalysts , both homogeneous and heterogeneous , have seen a meteoric rise in importance in the last three decades , and interest continues unabated .
this has been amply documented , for example , in special editions of major review journals . for organic transformations , gold in the oxidation state
+ i is o... | gold has seen a remarkable transformation from inert noble metal to highly reactive catalyst .
however , its organometallic chemistry contains many unknowns .
how certain can we be about the species involved in catalytic cycles ?
this perspective summarises recent discoveries . |
brown - mclean syndrome ( bms ) is an infrequently diagnosed condition , defined by peripheral corneal edema that spares the center .
clinically , bms is most often seen after cataract extraction but has been described after other surgeries as well ( e.g. , corneal transplantation ) [ 2 , 3 ] .
nonsurgical insults ... | the purpose of this manuscript is to report the case of a 12-year - old patient who presented for routine ophthalmic examination after congenital cataract surgery performed at 2 months of age .
the patient was diagnosed with bilateral brown - mclean syndrome by slit lamp examination .
no treatment was required beca... |
acute poststreptococcal glomerulonephritis ( psagn ) is a common glomerular cause of gross hematuria in children .
it commonly presents as nephritic syndrome with sudden onset of gross hematuria , edema , hypertension , and renal insufficiency .
varied presentations have been reported such as asymptomatic , mild sy... | posterior reversible encephalopathy syndrome ( pres ) is a rare clinicoradiologic condition manifesting with headache , seizures , altered sensorium , visual disturbances , and characteristic lesions on neuroimaging predominantly affecting the posterior regions of the brain .
we report a case of an 8-year - old boy w... |
in recent years , it has been established that in patients maintained on chronic hemodialysis ( hd ) there is a strong association between markers of inflammation , nutritional status , cardiovascular disease and overall morbidity and mortality .
it was found that 3060% of hd patients have evidence of activation of i... | summarybackgroundcd14 is a membrane glycoprotein that acts as a co - receptor for the detection of bacterial lipopolysaccharide ( lps ) .
mutual interaction between cd14 and lps plays an important role in the innate immune system .
increased serum soluble cd14 levels have been described in hemodialysis ( hd ) patie... |
it is believed that physical activity for the prevention of falls should primarily aim to
increase the strength of large groups of muscles , mainly in the lower limbs , as well as
improve gait , balance , and coordination parameters1 . among the organized exercise systems
only tai - chi has been
mentioned in th... | [ purpose ] to assess the effect of 12-weeks nordic walking training on gait parameters and
some elements of postural control .
[ subjects and methods ] sixty - seven women aged 65 to
74 years were enrolled in this study .
the subjects were divided into a nordic walking
group ( 12 weeks of nordic walking tra... |
cardiac rehabilitation ( cr ) is a multidisciplinary multifaceted intervention aiming at physical , psychological and social recovery of cardiac patients after a cardiac event or therapeutic intervention .
traditional indications for cr are related to coronary artery disease ( cad ) , including patients with myocardi... | backgroundin 2004 , the netherlands society of cardiology released the current guideline on cardiac rehabilitation .
given its complexity and the involvement of various healthcare disciplines , it was supplemented with a clinical algorithm , serving to facilitate its implementation in daily practice . although the al... |
type 2 diabetes mellitus ( t2 dm ) is a clinical syndrome characterized by elevated blood glucose caused by a combination of insulin resistance and progressive failure of insulin secretion by the -cells in pancreatic islets of langerhans [ 1 , 2 ] .
the cellular mechanisms underlying -cell failure in t2 dm are not we... | background and aims .
we here assess the effects of pscs on -cell function and apoptosis in vivo and in vitro .
materials and methods .
pscs were transplanted into wistar and goto - kakizaki ( gk ) rats .
sixteen weeks after transplantation , -cell function , apoptosis , and islet fibrosis were assessed . in vi... |
a 79-year - old woman with a history of hypertension was transferred in a near - shock state from a regional hospital where she had presented 10 days previously , complaining of one week of nausea , diarrhea , and nocturnal fever . despite various conservative treatments including antibiotics , dyspnea with palpitation... | the concomitant presence of posterior mitral annular calcification and infectious mitral valve lesions poses a technical challenge with considerable perioperative risk when using previously proposed techniques for mitral valve surgery .
herein , we report a case of the use of a modified surgical technique to successf... |
kawasaki disease ( kd ) is a form of systemic vasculitis , the etiology of which is unknown .
diagnosis is based on clinical signs raising suspicion of the disease , including fever of over 5 days in duration and at least four of the following five symptoms : bilateral bulbar conjunctival infection , changes in the o... | incomplete kawasaki disease ( ikd ) is considered to be a less complete form of kawasaki disease ( ckd ) , and several differences in the laboratory presentations of ikd and ckd have been noted .
we investigated serum procalcitonin levels in patients with ikd , ckd , and other febrile diseases ( a control group ) .
... |
central retinal vein occlusion ( crvo ) is a common cause of vision impairment which can occur at any given age .
most of the cases are unilateral ; bilateral cases are rare , usually having an underlying systemic illness such as a hyperviscosity syndrome or an inflammatory condition.1 here , we present the case of a... | central retinal vein occlusion ( crvo ) is a common pathology of the retinal vasculature .
patients with crvo usually present with a drop in visual acuity .
the condition bears no specific therapy ; treatment is aimed at the management of potentially blinding complications , of which there are many . with majority ... |
cardiac remodelling is central to the pathophysiology of heart failure ( hf ) and is an established prognostic factor in patients with hf .
left ventricular ( lv ) enlargement has been shown to be associated with an increased risk for adverse cardiac events , while reduced lv ejection fraction ( lvef ) is a powerful ... | aimsthe shift echocardiographic substudy evaluated the effects of ivabradine on left ventricular ( lv ) remodelling in heart failure ( hf).methods and resultseligible patients had chronic hf and systolic dysfunction [ lv ejection fraction ( lvef ) 35% ] , were in sinus rhythm , and had resting heart rate 70 bpm .
pat... |
glaucoma is characterized by progressive optic nerve damage resulting in irreversible loss of vision and is a leading cause of blindness worldwide.1 the only available treatment to delay the progression of glaucoma involves lowering the intraocular pressure ( iop ) .
iop reduction is most commonly accomplished by app... | micro - invasive glaucoma surgery with the glaukos istent or istent inject ( glaukos corporation , laguna hills , ca , usa ) is intended to create a bypass through the trabecular meshwork to schlemm s canal to improve aqueous outflow through the natural physiologic pathway .
while the istent devices have been evaluat... |
the process of aligning images so that the corresponding features can be related is called image registration .
image registration methods have been discussed and
classified in books [ 14 ] and surveys [ 510 ] .
a way to reduce the ad hoc nature of registration methods is to
require them to satisfy certain prop... | this paper presents a method for constructing symmetric and transitive algorithms for registration of image sequences from
image registration algorithms that do not have these two properties .
the method is applicable to both rigid and nonrigid registration
and it can be used with linear or periodic image sequenc... |
adrenal failure is a potentially fatal disorder , and the prevalence of primary and secondary adrenal failure is 93140 and 150280 per million , respectively .
because symptoms of adrenal failure such as anorexia , nausea , vomiting , weight loss and fatigue are rather non - specific , they may well be mistaken as tho... | a 62-year - old man , receiving chronic haemodialysis and suffering from alcoholic liver cirrhosis and chronic pancreatitis , presented with hypoglycaemic coma .
plasma cortisol was undetectable
( < 5.5 nmol / l ) with suppressed adrenocorticotropic hormone ( acth ) , which established a diagnosis of adrenal failur... |
chewing gum is a habit practiced regularly by a relatively high proportion of individuals in many countries including india , and its use has increased within the last decade . in 1999 , available data suggested that some 374 billion pieces of chewing gum were sold worldwide , representing approximately u.s .
besides... | background : chewing gum is a habit practiced regularly by a relatively high proportion of individuals in many countries including india , and its use has increased within the last decade .
the aim of this study was to determine the effects of sugar - free and sugar chewing gums on plaque deposition.materials and met... |
the central paradigm of protein science suggests that protein functions are directly controlled by protein structures . with the increasing number of solved protein structures
a number of semi or fully automated structure comparison methods have been developed based on methodologies like alignment of secondary struct... | encoding protein 3d structures into 1d string using short structural prototypes or structural alphabets opens a new front for structure comparison and analysis . using the well - documented 16 motifs of protein blocks ( pbs ) as structural alphabet
, we have developed a methodology to compare protein structures that ... |
connective tissue nevi of the skin are hamartomas , consisting predominantly from one of the components of the extracellular matrix namely collagen , elastic fibres or proteoglycans .
we hereby describe a case of eruptive collagenoma in a child which started at an early age of three and half years .
we report this ... | eruptive collagenomas are non familial connective tissue nevi of unknown etiology presented with an abrupt onset .
while most cases are reported in young adults , there is a paucity of literature in children .
we report a case of a 4-year - old girl , who presented with multiple asymptomatic , papules , plaques and... |
according the latest iteration of the who classification , subcutaneous panniculitis - like t - cell lymphoma(sptcl ) is refer to t - cell derivation cytotoxic tumor .
multiple subcutaneous nodules of varying size or necrotic , mostly located on the trunk , and extremities , may be misdiagnosed as panniculitis becau... | a 25-year - old man was diagnosised subcutaneous panniculitis - like t - cell lymphoma ( sptcl ) through biopsy of a nodule from the anterior chest . after the treatment with prednisone 90 mg 3 weeks and tapered off in 1 month ,
the disease released , but relapsed together with symptions of hemophagocytic syndrome ei... |
the pars plana vitrectomy ( ppv ) is a common procedure for the treatment of vitreoretinal diseases including vitreous hemorrhage , retinal detachment , epiretinal membrane , and macular hole . with the recent introduction of a sutureless vitrectomy technique
, vitreoretinal surgeons are now performing vitrectomies m... | purpose . to evaluate the diurnal intraocular pressure ( iop ) in eyes after vitrectomy compared to that of healthy eyes .
methods .
twenty - one patients who had undergone vitrectomy and 21 age- and gender - matched normal controls were enrolled during the same period .
we measured the diurnal iop every two hour... |
crohn s disease is a chronic relapsing and remitting , inflammatory bowel disease ( ibd ) that has a significant impact on health - related quality of life ( hrqol ) [ 1 , 2 ] .
hrqol has been recognized as an important health outcome and has been defined in the medical setting as a concept encompassing a broad rang... | background and aimscertolizumab pegol , a polyethylene glycolated fc - free fab was efficacious and well tolerated in patients with moderate - to - severe crohn s disease in a previously reported randomized , placebo - controlled study . in this paper , we report the effect of certolizumab pegol on health - related qua... |
obesity is a severe social problem in korea ( kang , 2013 ) . not only social and economic factors ( chung et al . , 2016 ) but also other various risk factors are important factors affecting the pathophysiologic and developing process of obesity . and life style and psychological factors are also related to hormone ch... | a main target of growth hormone ( gh ) is adipose tissue in human body .
the gh secretion in obesity patients is impaired .
it is needless to say that growth hormone receptor ( ghr ) is necessary in gh hormone signaling .
the purpose of the present study is to examine the association between single nucleotide pol... |
mycophenolate mofetil ( mpm ) , chemically known as 2-morpholinoethyl ( e)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate , is an immunosuppressive agent , inosine monophosphate dehydrogenase ( impdh ) inhibitor .
mpm is rapidly absorbed following oral administration and hyd... | two simple , selective , and rapid spectrophotometric methods are described for the determination of mycophenolate mofetil ( mpm ) in pure form and in tablets . both methods
are based on charge - transfer complexation reaction of mpm with p - chloranilic acid ( p - ca ) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone ( ... |
the contribution of nephrolithiasis related to end stage renal disease ( esrd ) in patients requiring renal replacement therapy has never been specifically evaluated .
nephrolithiasis still remains a too frequent and underappreciated cause of esrd and this is all the most unfortunate since such prognosis is now preve... | introduction : nephrolithiasis still remains a too frequent and underappreciated cause of end stage renal disease ( esrd).methods and patients : of the entire cohort of 7128 consecutive patients who started maintenance dialysis in our nephrology department between january 1992 and december 2006 , a total of 45 patients... |
it has been previously established that lung cancer could be induced in rats by exposure to radon and radon daughters .
although the oat - cell carcinomas that are common in humans were not found in rats , other histological types of lung carcinomas , especially squamous cell carcinomas and primitive lung adenocarcin... | |
in oral and maxillofacial surgery , facial bone fracture is a common trauma , resulting from traffic accident ( ta ) , assault , slip down , or industrial accident .
if the facial bone fracture is not appropriately treated , the result may be functional disability and an aesthetic problem . in some cases
bell repor... | purpose : this study examined patients with facial bone fracture visiting pusan national university dental hospital to understand the trends , and to enhance appropriate care and treatment for patients with facial bone fracture.methods:we investigated 531 patients presenting with facial bone fracture in yangsan and 802... |
though many patients suffer from peripheral arterial occlusive disease ( paod ) , diagnosis is often delayed .
if paod is not diagnosed and treated immediately , it is highly probable that the disease will progress to critical limb ischemia ( cli ) .
although treatment options , especially endovascular treatment mo... | abstractcritical limb ischemia ( cli ) , a frequently encountered disorder , is associated with a high rate of limb amputation and mortality . to identify patients at high risk for cli
, we developed a simple risk score for peripheral arterial occlusive disease ( paod).in our cross - sectional study , we first evalua... |
burn injury is a major cause of trauma to the human body , causing death and disability , with a long healing period and high health care costs .
the mortality rate of burn injury is decreasing with new treatment modalities , although secondary infections and long healing periods still affect mortality rates .
earl... | backgroundto investigate the effects of platelet - rich plasma on tissue maturation and burn healing in an experimental partial - thickness burn injury model.material/methodsthirty wistar albino rats were divided into 3 groups of 10 rats each .
group 1 ( platelet - rich plasma group ) was exposed to burn injury and t... |
malaria occurs often in poor , tropical and subtropical areas and still took an estimated 627 000 lives in 2012 , mostly those of children under five years of age in africa .
the culicidae mosquitoes are responsible for transmission of the worm parasites of heart dogs such as dirofileria immitis , dirofileria repense... | background : according to the national strategy plan on monitoring of insecticides resistance , this study was carried out to determine the base line susceptibility of the culicidae mosquitoes to the who - recommended insecticides in an endemic focus of malaria in southeastern iran.methods:larval collection was carried... |
adolescent obesity is a major public health problem in the united states , with prevalence rates disproportionately high among certain youth populations . non - hispanic black and hispanic children and adolescents are consistently more likely to be obese ( body mass index [ bmi ] 95% ) compared with non - hispanic whi... | objective . to understand the relationships between participation in different types of leisure time sport activity and adolescent obesity , and how those relationships might differ based on race , gender , and household income . methods .
data consisted of 6667 students that took part in the 1999 to 2006 national he... |
it is believed that the number of handicapped individuals is increasing in proportion to the general population .
children and adolescents with disabilities appear to have poorer oral health than their non - disabled counterparts .
variable access to dental care , inadequate oral hygiene and disability - related fa... | background and aims
children and adolescents with disabilities appear to have poorer oral health than their non - disabled counterparts .
the aim of this study was to assess the frequency and severity of oral diseases and treatment needs using world health organization criteria of caries , periodontal disease and m... |
a total of 22 mycobacterial strains were included in this work . to study the sequence diversity of t cell antigens in mtbc , we used illumina next - generation dna sequencing to generate nearly complete genome sequences from 20 strains representative of the six main human mtbc lineages , and one strain of mycobacteriu... | mycobacterium tuberculosis is an obligate human pathogen capable of persisting in individual hosts for decades . to determine whether antigenic variation and immune escape contribute to the success of m. tuberculosis , we determined and analyzed 22 genome sequences representative of the global diversity of the m. tuber... |
minimally invasive surgeries for gynecological conditions are becoming more common , especially since the wide - spread adoption of robotic surgery .
as surgeons grow increasingly comfortable with complex laparoscopic and robotic procedures , the rate - limiting step often becomes specimen retrieval through a small i... | introduction . with the widespread adoption of laparoscopic and robotic surgery ,
more and more women are undergoing minimally invasive surgery for complex gynecological procedures .
the rate - limiting step is often the delivery of an intact uterus or an unruptured adnexal mass . to avoid conversion to a minilapar... |
in the past two decades ,
interest in porphyrins with aromatically
extended -systems has been steadily on the rise .
today areas of their application encompass optical limiting , organic light - emitting diodes ( oleds ) and other electronic
devices , upconversion by sensitized triplet
progress in all of thes... | significant effort has been directed
in recent years toward porphyrins
with enhanced two - photon absorption ( 2pa ) .
however , the properties
of their triplet states , which are central to many applications , have
rarely been examined in parallel . here
we report the synthesis of
asymmetrically -extende... |
despite progression in the development of pharmacological therapy , treatment of the alpha synucleinopathy parkinson s disease ( pd ) as well as treatment of atypical parkinsonism proteinopathies , including a range of synucleinopathies and nonsynucleinopathic neurodegenerative disorders , is still challenging .
earl... | despite progression in the development of pharmacological therapy , treatment of alpha synucleinopathies , such as parkinson s disease ( pd ) and some atypical parkinsonism syndromes , is still challenging . to date
, our knowledge of the mechanisms whereby the pathological form of alpha - synuclein causes structural... |
the abdominal organ herniation trough the right diaphragm is even rarer due to the liver protective function .
the case reported concerns about a patient suffering from massive delayed right diaphragmatic hernia with right liver and bowel dislocation .
a 41-year - old patient was referred to our emergency departmen... | abstractright diaphragmatic hernia is an uncommon injury following abdominal trauma .
a case of delayed right post - traumatic diaphragmatic hernia is presented .
the patient referred us with wheezing and cough since 1 month .
a chest - abdominal computed tomography scan demonstrated a large diaphragmatic defect ... |
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