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gamma - aminobutyric acid ( gaba ) receptora ( gabaa ) receptors are members of the large cys - loop super - family of evolutionarily related and structurally similar ligand - gated ion channels that also includes the nicotinic acetylcholine , glycine , and 5-ht3 receptors . the gaba receptor is predominantly expresse... | in a previous report , we demonstrated that ginsenoside rc , one of major ginsenosides from panax ginseng , enhances -aminobutyric acid ( gaba ) receptora ( gabaa)-mediated ion channel currents .
however , little is known about the effects of ginsenoside metabolites on gabaa receptor channel activity .
the present ... |
the bael fruit ( aegle marmelos correa ) has been attributed with various nutritional and therapeutic properties .
the bael fruit pulp contains many functional and bioactive compounds such as carotenoids , phenolics , alkaloids , coumarins , flavonoids , terpenoids , and other antioxidants which may protect against c... | the effect of incubation time , incubation temperature , and crude enzyme concentration was observed on the yield , viscosity , and clarity of the juice obtained from bael fruit pulp .
the recommended enzymatic treatment conditions from the study were incubation time 475 min , incubation temperature 45c , and crude ... |
hypoparathyroidism - deafness - renal dysplasia ( hdr ) syndrome ( mim 146255 ) , also known as barakat syndrome , is a rare autosomal dominant disorder named from a triad of hypoparathyroidism , sensorineural deafness , and renal dysplasia .
sensorineural deafness could be the most common clinical feature , while hy... | background : hypoparathyroidism - deafness - renal dysplasia ( hdr ) syndrome is an autosomal dominant disorder primarily caused by haploinsufficiency of gata binding protein 3 ( gata3 ) gene mutations , and hearing loss is the most frequent phenotypic feature .
this study aimed at identifying the causative gene muta... |
the prevalence of type 2 diabetes mellitus ( t2 dm ) is rising globally , especially in asian indians . decreased bone mineral density ( bmd )
is an established complication of type 1 diabetes mellitus and has been attributed to early age at diagnosis leading to decreased bone accrual , long duration , prolonged poor... | objective : to assess bone mineral density ( bmd ) in type 2 diabetes mellitus ( t2 dm ) patients and its relation , if any , to clinical , hormonal and metabolic factors.materials and methods : a prospective evaluation of 194 t2 dm patients ( 97 men and 97 women ) was carried out .
bmd was done with dual energy x - ... |
zostao dobrze udokumentowane , e starszy wiek , przewleke choroby wspistniejce ( takie jak cukrzyca , przewleka obturacyjna choroba puc itp . )
i pogorszy oglne wyniki operacji pomostowania aortalno - wiecowego ( coronary artery bypass cabg ) z jednoczesn napraw niedokrwiennej niedomykalnoci zastawki mitralnej .
p... | introductionit is well documented that older age , chronic concomitant diseases ( such as diabetes mellitus , chronic obstructive lung disease , etc . ) , and poor left ventricular function can increase the postoperative complication rate and worsen the general outcomes of coronary artery bypass ( cabg ) and concomitan... |
in view of the fact that in the kitchens used for communal catering , microroganisms are often introduced through raw foodstuffs and personnel , several legal measures aimed at infection prevention have been enacted ( infection control policies , temperature control regulations for assurance of the cold - hot chain , r... | a problem that is often overlooked or simply not given enough attention : the food served to patients from the kitchen is not sterile . if food is allowed to stand at room temperature for a long time , both in the case of food cooked for lunch and of food intended for supper which has been previously chilled , there is... |
severe combined immunodeficiency ( scid ) refers to a group of life - threatening fatal , congenital disorders characterized by absent or reduced t - cell number and reduced or non - functional b - cells .
an early diagnosis of scid allows for avoidance of exposure to infections , live virus vaccines and non - irradi... | purposesevere combined immunodeficiency ( scid ) encompasses a group of disorders characterized by reduced or absent t - cell number and function and identified by newborn screening utilizing t - cell receptor excision circles ( trecs ) .
this screening has also identified infants with t lymphopenia who lack mutation... |
in vertebrates , melatonin and its signaling through g - protein - coupled receptors ( gpcrs ) play a fundamental role in the circadian modulation of physiology and behavior .
melatonin is a highly diffusible hormone secreted at night by the pineal organ , which in nonmammalian vertebrates is directly light sensitive... | summarymelatonin , the hormone of darkness , is a key regulator of vertebrate circadian physiology and behavior . despite its ubiquitous presence in metazoa
, the function of melatonin signaling outside vertebrates is poorly understood . here
, we investigate the effect of melatonin signaling on circadian swimmin... |
superoxide dismutases ( sod , ec 1.15.1.1 ) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide [ 13 ] .
they play an important antioxidant defense role in skins exposed to oxygen . in this regard ,
for the treatment of systemic inflammatory diseases including skin u... | superoxide dismutase ( sod , ec 1.15.1.1 ) plays an important antioxidant defense role in skins exposed to oxygen .
we studied the inhibitory effects of al3 + on the activity and conformation of manganese - containing sod ( mn - sod ) .
mn - sod was significantly inactivated by al3 + in a dose - dependent manner . ... |
the glycerol 3-phosphate can then be reduced to dihydroxyacetone phosphate which enters the glycolytic pathway , or be used as the backbone for the formation of glycerolipids ( triglycerides and plasmalogens ) as well as glycerol phospholipids .
glycerol kinase deficiency ( gkd : mim : 307030 ) is an x - linked inbor... | glycerol kinase deficiency ( gkd ) is an x - linked inborn error of metabolism at the interface of fat and carbohydrate metabolism .
we report a male patient with gkd and a novel insertion of tt in exon 5 at position 378 of the gk cdna ( 378379instt ) .
this resulted in a premature stop codon and 0.8% normal gk act... |
caffeine and theophylline are two methylxanthines that have been used to treat asthma , although their exact mechanisms of action are still unknown [ 1 , 2 ] .
the bronchodilating property of theophylline is largely attributed to inhibition of phosphodiesterase ( pde ) activity or the release of catecholamines , ther... | bronchodilators are the first line therapy during acute asthmatic exacerbations to reverse airway obstruction primarily by relaxing airway smooth muscle
. only three categories of bronchodilators exist in clinical practice : -adrenergic agonists , anticholinergics , and methylxanthines .
each of these categories ha... |
dmd is an inherited x - linked disorder with an incidence of 1 in 3,500 male births , and is due to the absence of dystrophin , a large protein linking the intracellular cytoskeleton to the extracellular matrix .
it follows a predictable clinical course marked by progressive skeletal muscle weakness , myocyte hypertr... | summarybackgroundduchenne muscular dystrophy ( dmd ) is a genetic neuromuscular disorder that affects skeletal muscles and cardiac muscle tissue . in some cases ,
myocardial injury secondary to hypoxia can lead to dilative cardiomyopathy ( dcm ) .
a genetic defect in the dystrophin gene may increase the susceptibil... |
lots of research is performed on epitaxial thin films and heterostructures of complex oxides because of the wide range of functional properties that can be obtained by tuning the composition and structure of the materials . due to the development of several growth techniques
, nowadays it is possible to make a large ... | atomically defined substrate surfaces are prerequisite for the epitaxial growth of complex oxide thin films . in this protocol ,
two approaches to obtain such surfaces are described .
the first approach is the preparation of single terminated perovskite srtio3 ( 001 ) and dysco3 ( 110 ) substrates .
wet etching w... |
pseudomyxoma peritonei ( pmp ) is an extremely rare disease , with an annual incidence of approximately one case per million .
although such tumours are typically slow - growing , they vary highly in their invasive and metastatic capacity . due to the heterogenous nature of pmp ,
proposed dividing pmp into 3 catego... | peritoneal mucinous carcinomatosis is an aggressive subtype of pseudomyxoma peritonei , which often leads to inoperable bowel obstruction and , ultimately , death . due to the poor prognosis , treatment is often symptomatic and aimed at alleviating the symptoms pain , nausea , and vomiting associated with gastrointes... |
bupropion extended - release ( xl ) is an important pharmacological option except nicotine for the treatment of smoking cessation .
it is thought to act on nicotine addiction by blocking dopamine reward pathway and reducing withdrawal symptoms that arise due to noradrenaline pathway furthermore , bupropion is used fo... | present report describes a 46 year old male patient with a diagnosis of major depression who developed tardive dyskinesia during bupropion therapy .
our patient had no history of neuroleptic use and his laboratory and neurologic examinations were normal .
he had no family history of neurologic diseases .
although... |
subepithelial tumors ( sets ) in the stomach are usually found incidentally during endoscopic examinations .
most gastric sets do not cause symptoms and were formerly considered to have a benign nature , such as lipomas , inflammatory fibroid polyps , or several neural origin tumors ( i.e. , schwannomas ) . however ,... | endoscopic resection of gastric subepithelial tumors ( sets ) has several advantages over biopsy techniques , such as superior diagnostic yield and definite diagnosis .
removal of gastric sets and histopathologic confirmation should be considered whenever gastric sets are highly suspected to have malignant potential ... |
bacterial vaginosis ( bv ) is the most common cause of vaginal discharge in reproductive age women , is present in approximately 29% of women in the united states , and is characterized by vaginal colonization with anaerobic bacterial species along with loss of lactobacilli .
the clinical sequelae of bv are significa... | objective : evaluate predictors of vaginal colonization with lactobacilli after treatment for bacterial vaginosis ( bv ) . methods .
vaginal fluid specimens from women with bv underwent qpcr for lactobacillus crispatus , l. jensenii , and l. iners pre- and posttreatment .
results .
few women with bv were colonize... |
3 full factorial design was used for the optimization . the levels for the selected independent variables
y = b0 + b1x1 + b2x2 + b12x1x2 + b11x12 + b22 x22 on the basis of the preliminary trials a 3 full factorial design was employed to study the effect of independent variables i.e. drug - to - polymer - to - polymer... | the purpose of this research was to design , and evaluate multiparticulate systems for chronotherapeutic delivery of beta blocker containing biodegradable polymers coated with ph sensitive polymers in hypertension .
chitosan was used as a carrier for drug delivery and eudragit s100 was used as an enteric coating poly... |
the concept behind personalized / precision medicine is intuitive : patients are better modeled by a subgroup of patients that are most like them , rather than a larger , more general population of patients .
conceivably relevant biomarkers can be used to define subgroups of patients , and a patient s subgroup affili... | there are still many open questions in data - analytic research pertaining to biomarker development in the era of personalized / precision medicine and big data . among them
is the question of what constitutes best practice for the extraction of prioritized lists of candidate biomarkers from smaller studies that are ... |
long regarded as a uniform group of tumors that differed only as a function of anatomic site , ongoing studies indicate that hnsccs may not be as homogenous as previously supposed .
recognition of distinct molecular genetic profiles now permits finer resolution of hnscc into distinct subtypes that differ with respect... | the longstanding notion that head and neck squamous cell carcinoma ( hnscc ) is a uniform disease process is changing .
divergence in epidemiologic trends among hnsccs arising in different anatomic subsites has introduced a view that hnscc is a heterogeneous group .
analysis of molecular genetic changes discloses n... |
x - ray crystallographic studies on multisubunit rna polymerases ( rnaps ) from eukaryotes , bacteria and archaea have revealed highly related enzymes with structurally conserved active sites . for eukaryotic and bacterial enzymes , crystal structures of transcribing complexes have been solved , showing the locations o... | a comprehensive survey of single amino - acid substitution mutations critical for rna polymerase function published in journal of biology supports a proposed mechanism for polymerase action in which movement of the polymerase ' bridge helix ' promotes transcriptional activity in cooperation with a critical substrate - ... |
regression models are developed using statistical techniques to measure the response of outcomes of interest to predictor variables . in general ,
model development begins by employing a combination of literature search and expert panel knowledge to select factors believed to influence outcome variables of interest s... | clinical risk - adjustment , the ability to standardize the comparison of individuals with different health needs , is based upon 2 main alternative approaches : regression models and clinical categorical models . in this article , we examine the impact of the differences in the way these models are constructed on end ... |
fat tissue is a source of many significant cytokines , such as leptin , adiponectin , and resistin , affecting metabolism , energetic balance , and modifying peripheral insulin sensitivity of tissues , as well as carbohydrate metabolism .
cytokine with mostly multipotential performance is leptin , encoded by the so -... | childhood cancer survivors are in augmented risk for developing obesity . for many factors leptin and leptin receptor gene polymorphism play an important role in the development and metabolism not only of fat , but also , bone tissue . the aim of the analysis was to find the relationships between q223r , leptin levels ... |
the online version of this article ( doi:10.1007/s10886 - 010 - 9821 - 3 ) contains supplementary material , which is available to authorized users .
most insects rely on chemical compounds ( pheromones ) to identify and attract conspecific mates ( wyatt , 2003 ) .
the chemical composition of mating pheromones may ... | male orchid bees collect volatiles , from both floral and non - floral sources , that they expose as pheromone analogues ( perfumes ) during courtship display .
the chemical profile of these perfumes , which includes terpenes and aromatic compounds , is both species - specific and divergent among closely related line... |
an extended -conjugated system
is generally considered to
be a prerequisite for high electron mobility and , consequently , a
good performance in organic thin film devices .
pentacene and rubrene
are typical examples of this class of molecules . from the point of
view of mesomeric structures , 5,12-dihydro ... | quinacridone ( qa ) has recently gained
attention as an organic semiconductor
with unexpectedly high performance in organic devices .
the strong
intermolecular connection via hydrogen bonds is expected to promote
good structural order . when deposited on a substrate ,
another relevant
factor comes into pl... |
liver tumors are the third most common malignancies of the gastrointestinal tract worldwide . in the western world
, secondary liver tumors are more frequent than primary ones , even though the incidence of hepatocellular carcinoma ( hcc ) has been increasing over the last 20 years , especially in males .
nearly 80... | purpose .
available tumor markers have low sensitivity / specificity for the diagnosis of liver tumors .
the present study was designed to evaluate the oxidoreductive status of the liver as surrogates of tumor subsistence and growth .
methods .
glutathione species ( gsh : gssg ) , ophthalmate ( oa ) concentrati... |
primary hyperparathyroidism ( phpt ) is one of the most common endocrine conditions particularly in postmenopausal women .
phpt is being diagnosed with increasing frequency mainly as a result of the introduction of routine serum calcium measurements .
many new clinical features , such as hypertension , mental distu... | background . primary hyperparathyroidism ( phpt ) is one of the most common endocrine conditions and is accompanied by hypertension and increased cardiovascular mortality .
the purpose of this study was to evaluate the effect of parathyroidectomy on systolic and diastolic blood pressure ( bp ) in hypertensive patient... |
forensic dentistry is a challenging and fascinating branch of forensic science that involves the application of dental sciences in the identification of deceased individuals through the comparison of ante- and post - mortem records . from ad 66 until date , dental identification has proved vital in identifying deceased... | background : forensic science is defined as a discipline concerned with the application of science and technology to the detection and investigation of crime and administration of justice , requiring the coordinated efforts of a multidisciplinary team .
dental identification remains one of the most reliable and frequ... |
physicochemical gradients have long been documented , but only recently has environmental shotgun sequencing allowed the associated functional ( gene - based ) gradients of an ecosystems biota to be addressed .
macroscale functional gradients have been inferred from oceanic metagenomic data sets , both horizontally (... | to investigate the extent of genetic stratification in structured microbial communities , we compared the metagenomes of 10 successive layers of a phylogenetically complex hypersaline mat from guerrero negro , mexico .
we found pronounced millimeter - scale genetic gradients that were consistent with the physicochemi... |
chronic inflammation induced by biological , chemical , and physical factors has been found to be associated with the increased risk of cancer in various organs [ 13 ] ( table 1 ) .
inflammation activates a variety of inflammatory cells , which trigger oxidant - generating enzymes such as inducible nitric oxide synth... | chronic inflammation induced by biological , chemical , and physical factors has been found to be associated with the increased risk of cancer in various organs .
we revealed that infectious agents including liver fluke , helicobacter pylori , and human papilloma virus and noninfectious agents such as asbestos fiber ... |
sudden cardiac arrest is linked more with structural heart disease ; however it is also associated with pulmonary embolism ( pe ) .
the conventional treatment of pe is anticoagulation but the risk of bleeding is high in the situations where patients undergo prolonged cardiac arrest and hypothermia management .
we h... | a 52-year - old non - smoking caucasian male , who was admitted to our emergency room after he was found unconscious in the bathroom , went into cardiac arrest requiring prolonged cardiopulmonary resuscitation ( cpr ) and hypothermia therapy .
cardiac catheterization showed non - obstructive coronary arteries and fur... |
acute lymphoblastic leukemia ( all ) arises from immature hematopoietic progenitors that are destined to develop into lymphocytes but acquire somatic gene mutations , which results in altered proliferation and arrest of differentiation .
although regulation of growth and differentiation is altered in these cells , th... | acute lymphoblastic leukemia ( all ) arises from immature b and t lymphoblasts .
an increasing array of cytogenetic and molecular markers have been identified in all , which allows for increasingly sophisticated prognostication , as well as identification of potential new targets for therapy .
the treatment of all ... |
a 39 year - old female patient with ovarian cancer ( stage iii ) underwent tah with bso ( total abdominal hysterectomy and bilateral salpingo - oophorectomy ) at another hospital . during chemotherapy with paclitaxel and carboplatin ( day 9 , pod 16 ) , she showed melena followed by hematochezia .
she was diagnosed w... | there are various causes to a low level of consciousness in patients in the intensive care unit . neurological injury , infection , and metabolic disarray
are considered as some of the causes .
a 39 year - old female patient was transferred to our hospital with septic shock due to ascending colon perforation .
th... |
the most common indication for hysterectomy is uterine fibroids , followed by dysfunctional uterine bleeding . regarding the procedure
traditionally , abdominal hysterectomy ( ah ) has been used for gynecological malignancy or if the uterus is enlarged . vaginal hysterectomy ( vh )
was originally used only for prol... | the objective of this study was to compare surgical outcomes for laparoscopically assisted vaginal hysterectomy ( lavh ) with total laparoscopic hysterectomy ( tlh ) in three teaching hospitals in the netherlands .
this study is a multicenter cohort retrospective analysis of consecutive cases ( canadian task force cl... |
such a condition is also termed malignant or pathologic myopia when accompanied by choroid retinal degeneration and a series of pathological changes in the macular region .
high myopia is very common , found in 921% of asian adults , and its incidence is increasing worldwide . with the advent of optical coherence t... | objective . to observe the fellow eye in patients undergoing surgery on one eye for treating myopic traction maculopathy
. methods .
99 fellow eyes of consecutive patients who underwent unilateral surgery to treat mtm were retrospectively evaluated .
all patients underwent thorough ophthalmologic examinations , i... |
thirteen patients with php type 1 visited the department of pediatrics at chiba university
hospital between 1995 and 2004 .
the diagnosis of php was based on the following criteria:(1 )
the presence of hypocalcemia ( serum calcium less than 8.5 mg / dl ) with elevated serum pth
levels ( above twice the upper no... | pseudohypoparathyroidism ( php ) is a metabolic disorder characterized by organ resistance
to the action of parathyroid hormone .
php type 1 is subclassified into two apparent
disorders , type 1a ( php1a ) and type 1b ( php1b ) .
patients with php1a show albright
hereditary osteodystrophy including short stat... |
use of three to four psychoactive medicines concurrently doubled the risk of falls resulting in hospitalization , while concurrent use of five or more tripled the riskuse of psychoactive medicines at any dose increased the risk of hospitalization for falls .
there was a fourfold increased risk of hospitalization for ... | backgroundlittle is known about the impact of taking multiple psychoactive medicines on the risk of hospitalization for falls.objectiveto identify the association between multiple psychoactive medicine use and hospitalization for falls.methodsa retrospective cohort study was conducted between july 2011 and june 2012 in... |
although ovarian cancer is usually diagnosed in postmenopausal women , 12% of ovarian cancer cases occur in women of child - bearing age .
several reports have estimated that 3% to 17% of all eocas occur in woman younger than 40 years of age .
ovarian germ cell tumors ( gcts ) account for 20% to 25% of all ovarian ... | objective : to show the feasibility and safety of robotic - assisted laparoscopic fertility - sparing surgery for early - stage ovarian cancer in women of reproductive age.methods and design : the first patient was a 29-year - old para 0 woman with well - differentiated endometrioid adenocarcinoma of the ovary and comp... |
thyroid cancer is the most common endocrine cancer ( approximately 1.0%1.5% of all new cancers diagnosed each year in the usa ) , and its incidence has continuously increased in the last three decades all over the world .
this trend is present on every continent ( table 1 ) except africa , where detection is possibly... | background . in the last decades
, thyroid cancer incidence has continuously and sharply increased all over the world .
this review analyzes the possible reasons of this increase . summary .
many experts believe that the increased incidence of thyroid cancer is apparent , because of the increased detection of sma... |
a 27-year - old pregnant g4p2 ( 28th gw ) , born in western africa but living in italy since 2012 , presented to the emergency department ( ed ) of our institution with headache , vomiting , diarrhea , and pelvic and low back pain .
she contracted malaria in 2007 in western africa , but did not mention this on admiss... | malaria is associated with high rates of morbidity and mortality worldwide , particularly in africa , southeast asia and south america .
nonetheless , several cases of malaria have been reported in western countries involving travelers from endemic areas , though very few involve pregnant women . in this article
, ... |
a common characteristic of these enzymes is that they are normally tightly regulated in unstimulated cells .
stimulation ( e.g. , by binding of a growth factor to the extracellular domain of a receptor tyrosine kinase ) leads to a rapid , transient increase in tyrosine kinase activity .
most oncogenic tyrosine kina... | the insulin - like growth factor i receptor ( igf1r ) is overexpressed in several forms of human cancer , and it has emerged as an important target for anticancer drug design .
cancer genome sequencing efforts have recently identified three somatic mutations in igf1r : a1374v , a deletion of s1278 in the c - terminal... |
at present , tuberculosis ( tb ) remains to be one of the world 's most serious health concerns . in 2014 , the who reported 9 million new tb cases and about 1.5 million deaths .
the increasing incidence of infection with antibiotic - resistant strains of mycobacterium tuberculosis is an alarming trend of recent year... | the search for factors that account for the reproduction and survival of mycobacteria , including vaccine strains , in host cells is the priority for studies on tuberculosis . a comparison of bcg - mycobacterial loads in granuloma cells obtained from bone marrow and spleens of mice with latent tuberculous infection and... |
lipid - rich carcinoma is a very rare histological variant of breast cancer that accounts for less than 1% of all breast cancers .
it is composed of clear to vacuolated cytoplasm with abundant neutral lipid present within 90% of the tumor cells .
lipid - rich carcinomas are considered to behave aggressively and hav... | a 57-year - old japanese woman with schizophrenia , who had received long - term treatment with neuroleptics , noticed a painless , pea - sized lump in her right breast .
she was admitted to our hospital and a malignant tumor was diagnosed .
the patient underwent a conservative radical mastectomy ( patey 's operati... |
health profession schools use interviews during the admissions process to identify certain non - cognitive skills that are needed for success in diverse , inter - professional settings .
this study aimed to assess the use of interviews during the student admissions process across health disciplines at schools in the ... | |
stent assisted coiling ( sac ) has been increasingly performed in patients with wide necked complex aneurysm.1)15)18)27)28 ) however , the risk of complications increases with the use of stent assistance.14)22)25)30 ) these complications include thromboembolism , such as parent artery occlusion , distal embolic infarct... | stent assisted coiling ( sac ) is a useful technique for the treatment of wide necked complex aneurysm . as the frequency of sac increases , stent - related complications such as thromboembolism , aneurysm rupture , and vessel rupture have been reported .
however , to the best of our knowledge , carotid - cavernous f... |
these voiding problems may result from medication , cognitive changes ,
physical impairments , or neurological etiologies1 .
patients with spinal cord injury in the thoracic region were
selected for this study , and we monitored changes in their bowel function after performing
manual therapy along the colon . a... | [ purpose ] the purpose of this study was to observe the effects of manual therapy on
bowel function of patients with spinal cord injury . [ subjects ]
the participants were 20
patients with spinal cord injury .
[ methods ] manual therapy was applied to the intestine
and along the colon ascendens , transverse... |
cataract surgery with intraocular lens ( iol ) implantation is a successful surgical procedure which has dramatically improved because of development in new techniques and devices , making it safer than it was two decades ago .
sutureless clear corneal incision , continuous curvilinear capsulorhexis ( ccc ) , phacoem... | posterior chamber intraocular lens ( pc - iol ) subluxation is uncommon but represents one of the most serious complications following phacoemulsification .
late spontaneous iol - capsular bag complex dislocation is defined as occurring three months or later following cataract surgery . unlike early iol dislocation ,... |
tumor necrosis factor- ( tnf- ) is a pleiotropic cytokine which plays a major role in the development , homeostasis , and adaptive responses of the immune system .
in fact , it is central to the initiation and maintenance of inflammation in multiple autoimmune and nonautoimmune disorders .
tnf- , which is released... | tumoral necrosis factor plays a central role in both the inflammatory response and that of the immune system .
thus , its blockade with the so - called anti - tnf agents ( infliximab , etanercept , adalimumab , certolizumab pegol , and golimumab ) has turned into the most important tool in the management of a variet... |
the natural homeostatic processes in the human body often result in a physical decline with age .
we lose bone mineral density ( bmd ) , muscle mass , and strength and we have an increase in fat mass , ultimately resulting in reduced physical performance [ 14 ] . as such , with aging there is generally an increased r... | chronological aging is associated with a decrease in skeletal muscle mass and bone mineral density , an increase in fat mass , frequency of falls and fractures , and the likelihood of obesity , diabetes , and coronary heart disease .
resistance exercise has been shown to counter all of these effects of aging and , in... |
poland 's syndrome is characterised by unilateral chest wall and upper limb abnormalities , with an incidence of 1:30,000 - 100,000 live births .
the thoracic manifestations may vary from mild hypoplasia to complete absence of the pectoralis major muscle and/or costal cartilages , breast and nipple hypoplasia or apla... | this study aims to present the case of a female patient with poland 's syndrome and pectus excavatum deformity who underwent breast and chest wall reconstruction with a pre - shaped free deep inferior epigastric perforator flap . a 57-year - old female patient with poland 's syndrome and pectus excavatum presented with... |
hospital care utilization increases directly with age : the population aged 75 years or older spends , on average , 2.6 days per year in the hospital compared with 0.6 days for all other age groups.1 this can be a concern as the hospital setting is an immobilizing environment where patients may have multiple tethers f... | backgroundfunctional decline of hospitalized older adults is common and triggers health care expenditures .
physical therapy can retard the functional decline that occurs during hospitalization .
this study aims to examine whether shared situational awareness ( ssa ) intervention may enhance the benefits of physica... |
prurigo nodularis ( pn ) of hyde , also known as nodular prurigo , is a chronic skin disease of unknown etiology .
the hyperkeratotic lesions tend to be symmetrical and occur over the extensor surfaces of the extremities .
pn has been associated with a range of systemic conditions such as hiv / aids , depression , ... | prurigo nodularis ( pn ) is a chronic dermatoses characterized by intensely pruritic , excoriated , or lichenified nodules .
standard therapy includes corticosteroids , antihistamines , and phototherapy ; however , treatment results are often inadequate or transient .
thalidomide and its analogue lenalidomide are i... |
hepatic sinusoidal obstruction syndrome ( sos ) , also known as veno - occlusive disease ( vod ) , is a serious , life - threatening complication that is sometimes observed after hematopoietic - stem cell transplantation ( hsct ) ( 1,2 ) .
pathophysiologically , sos results from the activation of the sinusoidal endot... | hepatic sinusoidal obstruction syndrome ( sos ) , a serious complication that mainly occurs after hematopoietic - stem cell transplantation ( hsct ) , is caused by damage to the sinusoidal endothelial cells after the obstruction of the sinusoid .
recently , hepatic sos was reported to occur after non - hsct chemother... |
o objetivo deste estudo foi avaliar , in vitro , a qualidade do preenchimento de canais radiculares curvos com a pasta de hidrxido de clcio [ ca(oh)2 ] ultracal ( ultradent ) , associada ou no a cones de guta - percha contendo hidrxido de clcio ( calcium hydroxide plus points , roeko ) .
cento e vinte razes de dentes... | purposethe aim of this study was to evaluate , in vitro , the quality of calcium hydroxide [ ca(oh)2 ] paste filling ( ultracal , ultradent ) associated or not with ca(oh)2-containing gutta - percha points ( calcium hydroxide plus points , roeko ) in curved root canals.material and methodsone hundred and twenty roots o... |
the proteins pspa , im30 ( vipp1 ) , liah and yjfj belong to the pspa / im30 protein family .
structurally , all family members are predicted to be mainly helical , and pspa , im30 and liah form high - molecular weight homo - oligomeric ring structures .
solely yjfj is reported to not form such complexes , and , in... | abstractpspa , im30 ( vipp1 ) and liah , which all belong to the pspa / im30 protein family , form high molecular weight oligomeric structures . for all proteins membrane
binding and protection of the membrane structure and integrity has been shown or postulated . here
we discuss the possible membrane chaperoning a... |
the risks of systemic inflammation measured by distinct profiles of inflammatory proteins in newborn blood associated with placental colonization by specific groups of bacteria are presented as odds ratios in tables 1 and 2 .
the number of samples that tested positive for each organism or group of organisms is state... | the fetal response to intrauterine inflammatory stimuli appears to contribute to the onset of preterm labor as well as fetal injury , especially affecting newborns of extremely low gestational age . to investigate the role of placental colonization by specific groups of microorganisms in the development of inflammatory... |
increases for population have been observed in almost every country due to recent medical and technological advances . it is expected that an increase from 11% to 22% in the number of individuals that are 60 + between the years of 2000 and 2050 will occur in the world .
the population rate of individuals who were 65 ... | abstractbackgroundthis study examined the factors that affect loneliness of older people and their relationship with quality of life.methodsdata in this cross - sectional study were collected through survey form , ucla loneliness scale and quality of life ( qol ) short form ( sf-36 ) scale .
the total number of elder... |
the ability and efficiency of mastication is the first step in the digestion of food , and this ability declines with age ( locker , 2002 ; morley , 2001 ; takata et al . , 2006 ) .
masticatory ability is closely associated with maintaining adequate nutrition in older populations ( de morais et al . , 2013 ; kwon , s... | objective : the aim of the present study was to elucidate the influence of self - rated masticatory ability on independent living in community - dwelling older adults . method : a total of 1,377 subjects aged 65 and over who lived in kumamoto city , japan were participated in a survey to investigate critical factors fo... |
since the emergence of electroporation ( ep ) in the early 1980s , it has received appreciable attention in both chemotherapy and gene therapy . with this method , reversible perturbation of the lipid membrane
the ep could be induced by a large variety of pulses : high - voltage pulses which are typically short , low... | purposetransdermal electroporation has become one of the most promising noninvasive methods for drug administration , with greatly increased transport of macromolecules through the skin .
the cecal - contracting effects of repeated transdermal electroporation delivery and intravenous administration of neostigmine wer... |
while a great deal of attention has been given to the factors that determine cholesterol homeostasis , cholesterol excretion via bile in patients with cad has not been thoroughly examined [ 13 ] .
clinically , it became obvious that , despite effective cholesterol - modulating treatment ( e.g. , statins ) , the devel... | the impact of cholesterol and different classes of lipoproteins on the development of coronary artery disease ( cad ) has been investigated in extensively during the past 50 years .
the cholesterol metabolism is dependent on numerous factors , including dietary fat , fractional absorption of dietary cholesterol , tis... |
dental implantation is considered as one of the most widely employed procedures in dental practice . even though biocompatible osseointegrated dental materials are used for fabrication of dental implant
moreover , placement of dental implants in the maxilla may be complicated by certain anatomical landmarks such as t... | background : dental implantation is considered as one of the most widely employed procedures in dental practice .
nasopalatine duct cyst ( npdc ) is one of the most common developmental cysts in the oral cavity that develops from the proliferation of embryological epithelial remnants of nasopalatine duct.aim:the aim ... |
details of the design and methods for the select study and the selection extension study have been described previously . briefly , select was a double - blind parallel - group trial in which 621 male and female patients with rrms were randomized 1:1:1 to treatment with once - monthly subcutaneous injections of dac hyp... | objective : to assess the relationship between cd56bright natural killer ( nk ) cells and multiple sclerosis ( ms ) disease activity in patients with relapsing - remitting ms treated with daclizumab high - yield process ( dac hyp).methods : data were from patients enrolled in a 52-week randomized , double - blind , pla... |
central pontine myelinolysis ( cpm ) is a demyelinating condition affecting the pons characterized by an acute progressive quadriplegia , dysarthria , dysphagia , and alterations of consciousness .
pathologic features include prominent demyelination in the central pons with sparing of axons and neurons .
this condi... | central pontine myelinolysis is a demyelinating condition affecting the pons characterized by an acute progressive quadriplegia , dysarthria , dysphagia , and alterations of consciousness .
pathologic features include prominent demyelination in the central pons with sparing of axons and neurons .
this condition is ... |
perilymphatic fistula ( plf ) is an abnormal communication between the middle ear and the perilymphatic space , mostly due to laceration of the oval and/or round window , or congenital defects in the area of fissula ante fenestram or fossula post fenestram .
plf may be caused by external injury such as head trauma , ... | this study was designed to verify an eventual perilymphatic fistula ( plf ) in 264 patients with sensorineural hearing loss ( snhl ) and/or vertigo .
the patients were exposed to a low - frequency sound stimulation ( lfs ) on posturography to objectively test tullio 's phenomenon and hennebert 's sign .
endoscopes ... |
during september 2003 through may 2004 , serum samples were collected from 512 adult blood donors 1864 years old ( median 42 years ) and 188 children 24 years old .
the blood donors were unpaid voluntary donors ; the children were hospitalized in toulouse for surgery or trauma .
the prevalence of hev igg was determ... | using a validated sensitive assay , we found hepatitis e virus ( hev ) igg in 52.5% of voluntary blood donors in southwestern france .
this finding suggests hev is highly endemic to this region
. the high hev prevalence may reflect local dietary practices , such as eating uncooked pork and game products . |
in this issue of critical care , thiel and colleagues present a new method for tracking the changes in cardiac output in response to passive leg raising ( plr ) , one of the tests recently proposed to predict volume responsiveness in critically ill patients .
recent review articles have emphasised the relevance of ... | policies of fluid administration / restriction in critically ill patients have evolved over recent years .
abundant fluid resuscitation is encouraged during the early stage of severe sepsis . but a conservative fluid strategy is recommended in later stages , in particular when lungs are injured . both strategies are ... |
metabolic syndrome ( mets ) , a collection of cardiometabolic risk factors that includes obesity , insulin resistance , hypertension , and dyslipidemia , confers increased risks of coronary heart disease and cardiovascular disease ( cvd ) [ 15 ] . in terms of mechanism , both adipocytokine and vitamin d
a low adipone... | metabolic syndrome ( mets ) confers increased risks of cardiovascular disease ( cvd ) .
both vitamin d3 and adipocytokines ( especially adiponectin and leptin ) have a great impact on cvd and mets . in vitamin d3 metabolism ,
the vitamin d3 25-hydroxylase ( cyp27a1 ) and 25-hydroxyvitamin d3 1-alpha - hydroxylase (... |
this type of examination has been considered an important tool for diagnosis since its discovery .
however , awareness of the risks of using ionizing radiation for diagnostic purposes emerged soon after its discovery .
therefore , methods that selectively expose a patient to x - rays have been proposed , such as a ... | professionals performing radiographic examinations are responsible for maintaining optimal image quality for accurate diagnoses .
these professionals must competently execute techniques such as film manipulation and processing to minimize patient exposure to radiation .
improper performance by the professional and/... |
type 2 diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia in association with insulin resistance , impaired relative and/or absolute insulin production , and altered glucagon secretion [ 1 , 2 ] . at the onset of diabetes
two main processes are involved in its pathogenesis : progressive ... | metformin ( metf ) , historical antihyperglycemic drug , is a likely candidate for lifespan extension , treatment and prevention of sedentariness damages , insulin resistance , and obesity .
skeletal muscle is a highly adaptable tissue , capable of hypertrophy response to resistance training and of regeneration after... |
the specialty of family medicine emphasizes the importance of assessing the patient 's health , illness and disease within the context of family and community .
providing family - oriented primary care is one of the distinguishing features of this specialty .
conventionally , physician training focuses on an encoun... | background : companions often accompany the patient in family medicine clinics and may influence the consultation .
this study aims to determine the patients perspective regarding the role and influence of the companion in the consultation process.materials and methods : a cross - sectional study was conducted at the... |
chronic recurrent non - specific parotitis is characterized by recurrent episodes of swelling and pain of unknown etiology in the parotid gland .
sialography is a hallmark in the diagnosis of salivary gland disorders ; newer imaging modalities like ct - sialography , sialoendoscopy and mri can be used .
various tre... | backgroundchronic recurrent non - specific parotitis is characterized by recurrent episodes of swelling and pain of unknown etiology in the parotid gland .
sialography is a hallmark in the diagnosis of salivary gland disorders ; newer imaging modalities like ct - sialography , sialoendoscopy and mri can be used .
v... |
natural killer ( nk ) cells are large granular lymphocytes that have the ability to kill cells without prior sensitisation and therefore play an important role in host defence .
nk cell - mediated target cell killing is mainly implemented by two pathways , namely the perforin / granzyme pathway and the fas ligand ( f... | backgroundhepatic natural killer ( nk ) cells , the most cytotoxic cells of the natural occurring nk cells , are located in the liver sinusoids and are thus in a strategic position to kill arriving metastasising tumour cells , like colon carcinoma cells .
it is known that major histocompatibility complex ( mhc ) clas... |
the incidence of fungal liver abscess is rare compared to pyogenic or amebic liver abscess .
routes of exposure of bacteria can occur by biliary tree , portal vein , hepatic artery , direct extension , and cryptogenic abscess .
a 65-year - old female patient admitted with a complaint of upper abdominal pain for 15 ... | liver abscess is mostly either pyogenic or amebic .
fungal and mycobacterial liver abscesses are rare and mostly associated with immunosuppression .
the occurrence of fungal liver abscess with hydatid cyst was never reported previously .
this case created diagnostic difficulty , whether we are dealing with liver ... |
this cross - sectional study was conducted in the rural and urban field practice area of mahatma gandhi medical college and research institute , puducherry , from 1 december 2007 to 31 may 2008 on 214 elderly participants of age 60 years and above with no interventions .
we identified 225 eligible individuals from th... | background : the geriatric health problems are related to chronic disease as a result of increasing life expectancy.objective:this study was undertaken to assess the health problems of the elderly in puducherry.materials and methods : this cross - sectional study was carried out on 214 elderly persons from the age grou... |
bubble hair is an acquired hair shaft deformity characterized by bubble - like areas in the hair shaft seen with light microscopy and corresponding cavitary defects with scanning electron microscopy .
it occurs due to thermal injury caused to the hair by hair dryers , heating tongs or hot curls .
hair appears dry ,... | bubble hair is an acquired hair shaft abnormality characterized by multiple airfilled spaces within the hair shaft .
it is a result of thermal injury .
we report a classic case of 22-year - old female who complained of dry brittle hair of two - week duration .
patient had used hot iron on wet hair twice to straig... |
assessment of maximum aerobic capacity or vo2max has immense importance in the field of work physiology .
it is the primary determinant of physical work capacity and reflects the functional efficiency of cardiovascular , respiratory , and neuromuscular systems of our body .
assessment of this parameter is of pivota... | miners fitness test was assessed in terms of determination of maximum aerobic capacity by an indirect method following a standard step test protocol before going down to mine by taking into consideration of heart rates ( telemetric recording ) and oxygen consumption of the subjects ( oxylog - ii ) during exercise at di... |
protein - energy malnutrition ( pem ) is frequently found in patients with chronic renal failure and is reported to occur in 40% of dialysis patients . besides inadequate intake of proteins and calories , various other factors are involved in the development of pem in patients with renal failure including acidosis , in... | protein - energy malnutrition is frequently found in dialysis patients . many factors play a role in its development including deficient nutrient intake as a result of anorexia .
peritoneal dialysis ( pd ) solutions containing a mixture of amino acids and glucose in an appropriate ratio could serve as a source of foo... |
the recovery of exfoliated cells from biological fluids is a non - invasive technology which is in high demand in the field of translational research as well as during long - term experiments designed to minimize the sacrifice of long - lived or precious animals .
exfoliated epithelial cells can be used as surrogate ... | the recovery of exfoliated cells from biological fluids is a noninvasive technology which is in high demand in the field of translational research .
exfoliated epithelial cells can be isolated from several body fluids ( i.e. , breast milk , urines , and digestives fluids ) as a cellular mixture ( senescent , apoptoti... |
when patients with spinal cord injuries have pain as an accessory symptom , training in the
activities of daily living ( adl ) is affected and sometimes does not progress smoothly1 .
transcranial magnetic stimulation ( tms )
pulses have been used as a noninvasive and painless means of stimulating the brains of
... | [ purpose ] the aim of the present study was to determine whether repetitive transcranial
magnetic stimulation can improve sensory recovery of the lower extremities in
subacute - stage spinal cord injury patients .
[ subjects and methods ] this study was
conducted on 20 subjects with diagnosed paraplegia due to... |
supraorbital neuralgia is a form of localized headache in or above the eyebrow with possible extension in the entire skin region of nerve v1 .
supraorbital neuralgia is defined by the international classification of headache disorders by the following diagnostic criteria : paroxysmal or constant pain in the region of... | supraorbital neuralgia is a rare disorder accounting for 4% of incidence with hallmark of localized pain in or above the eyebrow , clinically characterized by the following triad : ( 1 ) forehead pain in the area supplied by the supraorbital nerve , ( 2 ) tenderness on either the supraorbital notch and ( 3 ) absolute ,... |
the european youth heart study ( eyhs ) is a population - based mixed longitudinal cohort study comprising two age - groups of 9-year - old children and 15-year - old adolescents from four european countries : denmark , portugal , estonia , and norway .
the aim of the eyhs was to investigate the personal , environmen... | objectivelower birth weight has been associated with a greater risk of metabolic diseases . the aim of this study was examine whether physical activity and aerobic fitness may modify associations between birth weigh and metabolic risk.research design and methodsthe european youth heart study is a population - based stu... |
the medical literature is replete with articles verifying the usefulness of laparoscopic procedures under local anesthesia .
recent research has examined the efficacy of microendoscopy with local anesthesia . in this series of patients , we focused on new technology to determine if microendoscopy could be utilized in... | background : the medical literature is replete with articles verifying the usefulness of laparoscopic procedures under local anesthesia .
recent research has examined the efficacy of microendoscopy with local anesthesia . in this series of patients , we focused on new technology to determine if microendoscopy could b... |
the sequencing of the human genome and the tentative identification of genes ' underlying susceptibility to mental disorders suggest the possibility of developing novel and more effective treatments for these disorders .
increased knowledge of the pathways for the pathophysiology of major mental illnesses can , it is... | pharmacogenomic developments hold promise for personalized medicine in psychiatry with adjusted therapeutic doses , predictable responses , reduced adverse drug reactions , early diagnosis , and personal health planning .
the prospects are exciting , but at the same time , these new techniques stand faced with import... |
coronary artery disease , as an important manifestation of atherosclerosis , is one of the most frequent causes of death and disability in the western world .
it has been proposed that inflammation is the driving force in atherosclerosis [ 2 , 3 ] , and strong evidence supports the central role of proinflammatory cyt... | the effects of anti - inflammatory plant extracts , such as black tea extract ( bte ) and resveratrol ( rsv ) could modulate cell activation leading to atherosclerosis , however there is little comparative information about how different endothelial cell types are affected by these compounds . in order to compare human... |
benign prostatic hyperplasia ( bph ) is the most common benign tumor in men , and its incidence is age - related .
symptoms of bph are caused by either obstructive components of the prostate glands or secondary changes to the bladder resulting from bladder outlet obstruction .
there are many treatment alternatives ... | purposetransurethral resection of the prostate ( turp ) is still considered the gold standard in the treatment of benign prostatic hyperplasia ( bph ) . however , open prostatectomy is indicated for prostate glands over 75 ml
. there have been few reports concerning the use of turp for large prostate glands over 100 ... |
the structure and the role of microvasculature has been progressively clarified in this last decade ( 1 , 2 ) .
we now have adequate information on the time course and percentage occurrence of microvascular obstruction ( mo ) .
we know that the venules are the site of leukocyte adhesion during inflammation and that... | background.about one third of patients with timi 3 after reperfusion have evidence of microvascular obstruction ( mo ) which represents an independent predictor of myocardial wall rupture .
this explains all efforts made to prevent mo .
magnetic resonance imaging ( mri ) has proved to be particularly useful in dete... |
solitary fdg avid liver lesion in oncological setting is often metastatic in nature . at the same time , such lesions are less likely to be of tuberculous etiology .
however , we report an unusual scenario in a 15 year old boy , of a solitary liver lesion in a case of round cell tumor , which on follow up imaging , t... | finding of focal 18f - fluoro - deoxyglucose ( fdg ) uptake in liver on fdg positron emission tomography / computed tomography ( fdg pet / ct ) in a known case of malignancy is often considered to be metastases .
we report a similar finding on fdg pet / ct in a case of ewing 's sarcoma of thigh , which turned out to ... |
the current understanding of multiple sclerosis ( ms ) as a progressive and long - term disabling disease has been based on studies of clinical course of the disease in areas of high disease prevalence [ 1 , 2 ] .
( 1989 ) have reported that approximately 50% of relapsing - remitting cases required an unilateral supp... | background . studies on the clinical course of multiple sclerosis have indicated that certain initial clinical factors are predictive of disease progression . regions with a low prevalence for disease , which have environmental and genetic factors that differ from areas of high prevalence , lack studies on the progress... |
es cell lines including the g9a knockout were cultured based on the standard protocol of the es core laboratory at johns hopkins university ( see full methods for details ) .
we differentiated es cells for 1824 days by removing leukemia inhibitory factor ( lif , chemicon ) from the medium and culturing in plates with... | higher eukaryotes must adapt a totipotent genome to specialized cell types with a stable but limited repertoire of functions .
one potential mechanism for lineage restriction is changes in chromatin , and differentiation - related chromatin changes have been observed for individual genes12 .
we have taken a genome ... |
ultrasound imaging is currently a commonly acknowledged and widely used method in the diagnosis of rheumatic diseases . in the recent years
modern equipment enables imaging of structures with the resolution up to 0.1 mm , which helps detect slight inflammatory foci and early joint damage .
additionally , doppler mo... | in the past years , ultrasound imaging has become an integral element of the diagnostic process in rheumatic diseases .
it enables the identification of a range of inflammatory changes in joint cavities , sheaths and bursae , and allows their activity to be assessed . in 2012 , experts of the european society of musc... |
major depressive disorder ( mdd ) is a highly prevalent psychiatric disorder affecting an estimated 1015% of the population worldwide ( bromet et al . , 2011 ) .
it is characterized by the persistent presence of several emotional , psychological and somatic symptoms including , but not limited to depressed mood , an... | major depressive disorder ( mdd ) is one of the most debilitating psychiatric diseases , affecting a large percentage of the population worldwide . currently , the underlying pathomechanisms remain incompletely understood , hampering the development of critically needed alternative therapeutic strategies , which furthe... |
a 75-year - old man with congestive heart failure and atrial fibrillation was transferred to our hospital for the management of dyspnea and coughing .
he had received posterolateral fusion with pedicle screw fixation of l4 and l5 foramina 5 years previously .
however , he suffered from sustained painful dysesthesia... | cerebrospinal fluid ( csf ) leak or shunt overdrainage is a well - known cause of orthostatic headaches and low csf pressures .
we report two cases of orthostatic headache with pneumocephalus on brain imaging .
the orthostatic headache developed after drainage of spinal operation site and epidural block .
brain m... |
pancreatic ductal adenocarcinoma ( pdac ) is a dismal disease with a 5-year survival rate of < 7%.1 despite tremendous efforts in pdac research and therapeutic development , no significant improvement in survival has been achieved within the last decades .
research efforts in pdac have traditionally focused on geneti... | pancreatic ductal adenocarcinoma ( pdac ) constitutes one of the most aggressive malignancies with a 5-year survival rate of < 7% . due to growing incidence , late diagnosis and insufficient treatment options , pdac is predicted to soon become one of the leading causes of cancer - related death .
although intensified... |
vaccines have been developed for many infectious diseases since the early twentieth century and they have provided numerous benefits to human society .
one of these benefits is the increased lifespan caused by the prevention of infectious diseases .
however , the types of diseases have changed alongside the increas... | chronic diseases such as obesity and diabetes are major causes of death and disability throughout the world .
many causes are known to trigger these chronic diseases , and infectious agents such as viruses are also pathological factors . in particular
, it is considered that adenovirus 36 infections may be associat... |
because the initial deposition pattern of inhaled particles of various toxic agents determines their future clearance and insult to tissue , respiratory tract deposition is important in assessing the potential toxicity of inhaled aerosols .
factors influencing the deposition of inhaled particles can be classified int... | |
when the treatment of acute heart failure and respiratory failure is difficult with existing conventional methods , treatment with an extracorporeal membrane oxygenator ( ecmo ) has become an alternative ( 1 ) . although heparin has been used as an anticoagulant among a variety of methods to reduce bleeding complicatio... | although the incidence of bleeding complications during extracorporeal membrane oxygenator ( ecmo ) support has decreased in various trials , bleeding is still the most fatal complication .
we investigated the ideal dosage and efficacy of nafamostat mesilate for use with ecmo in patients with acute cardiac or respira... |
menopause is a biological event rising from ovary failure , for which a diagnosis is retrospectively made after 12 consecutive months of amenorrhea that is not explainable through pathological causes and is associated with plasma values of follicle - stimulating hormone higher than 40 iu / l.1 it is preceded by a trans... | aim : to analyze the influence of the duration of habitual physical activity ( pa ) on the symptoms of climacterium / menopause and on several domains of the health - related quality of life ( qol ) in middle - aged women.methods:one hundred and four 45- to 59-year - old women were placed into three groups : group a , ... |
ramipril ( see scheme 1 ) contains not less than
98.0% of c23h32n2o5 ; ( 2s,3as,6as)-1-[(2s)-2-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a - hexahydro-2h - cyclopenta[d]pyrrole-2
carboxylic acid .
it belongs in a class of drugs
called angiotensin converting enzyme ( ace ) inhibitors ... | the fabrication and electrochemical evaluation of two pvc membrane - based ion - selective electrodes responsive for ramipril drug have been proposed .
the sensitive membranes were prepared using ramipril - phosphomolibdate and ramipril - tetraphenylborate ion - pair complexes as electroactive sensing materials in pl... |
natural
product modification with photoredox catalysis allows for
mild , chemoselective access to a wide array of related structures
in complex areas of chemical space , providing the possibility for
novel structural motifs as well as useful quantities of less abundant
congeners .
while amine additives have... | |
this may be accomplished by free dissection and clamping of the branches , which add time and operative trauma to the operation , or by occluding balloons introduced into branch ostia for , for example , visceral and large segmental arteries and stay sutures for small segmental ones , both of which clutters the operati... | during vascular surgical operations , there is a need for a simpler and more reliable method of temporary arterial occlusion than those currently employed , especially of heavily calcified arteries .
a thermosensitive polymer , legoo ( lg ) ( pluromed , woburn , ma ) , has been used successfully for temporary vascula... |
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