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dural arteriovenous fistulas are not rare in japan , especially examples involving the cavernous sinus .
however , reports of large series are few , and the clinical entity is not widely known .
the classical triad [ 2 , 3 ] of pulsating exophthalmos , conjunctival chemosis , and pulsatile - innitus are well - esta... | introduction .
the purpose of this paper is to clarify the clinical course , with the dural carotid cavernous fistula ( ccf ) , featuring a pallet of symptoms , paying special attention to radiological findings
. methods .
seventy - six consecutive patients with dural ccfs were investigated in detail , all of who... |
disease mapping contains a set of statistical methods , which leads to generate accurate maps based on estimations of incidence , prevalence , and mortality of diseases .
the oldest example of disease mapping is the address of cholera victims based on distance from water resources , which was presented in 1854 by joh... | introduction : disease mapping includes a set of statistical techniques that provides maps based on estimates of diseases rates .
bayesian ones are the most important models in this field .
they consider prior information on changes in the disease rates in overall map and spatial pattern of the disease .
these in... |
a few studies have found that abnormal findings on diffusion - weighted magnetic resonance imaging ( mri ) are useful for diagnosing cerebral fat embolism in the acute stage .
we applied serial mri to a case of cerebral fat embolism with cognitive impairment lasting for 2 months .
although marked resolution of the ... | backgrounda few studies have found that abnormal findings on diffusion - weighted magnetic resonance imaging ( mri ) are useful for diagnosing cerebral fat embolism in the acute stage.case reportwe applied serial mri to a case of cerebral fat embolism with cognitive impairment lasting for 2 months .
although marked r... |
dermatitis herpetiformis ( dh ) is an autoimmune skin disorder frequently associated with gastrointestinal disease characterized by intensely itchy , chronic papulo - vesicles , distributed symmetrically on extensor surfaces .
it has also been found associated with a number of other autoimmune illnesses including aut... | we report a case of 15-year - old girl who was diagnosed as a case of pituitary macroadenoma on computed tomography and magnetic resonance imaging ( mri ) scans for her complains of diminished vision in the left eye and headache . on investigation
she was found to have optic atrophy of left eye and primary hypothyroi... |
until recently , surgical management of breast cancer ( bc ) has focused on two main choices : tumor resection using breast conserving therapy ( bct ) and mastectomy with optional tissue displacement by breast reconstruction . from 2003
, the techniques that combine the skill of resection and reconstruction in one pr... | surgical management of breast cancer has evolved considerably over the last two decades
. there has been a major shift toward less - invasive local treatments , from radical mastectomy to breast - conserving therapy ( bct ) and oncoplastic breast surgery ( obs ) . in order to investigate the efficacy of each of the t... |
cardiovascular disease is one of the major causes of morbidity and mortality worldwide , especially among patients of chronic kidney disease ( ckd ) [ 1 , 2 ] .
there is an increasing evidence of cardiometabolic syndrome ( cms ) involvement in ckd [ 3 , 4 ] , but a causal relationship has not been proven .
cardiome... | objective was to assess whether the concentration of malondialdehyde ( mda ) as a marker of lipid peroxidation and serum concentration of matrix metalloproteinase-9 ( mmp-9 ) are involved in the process of atherosclerosis in chronic kidney disease ( ckd ) patients nondialysis - dependent and those on peritoneal dialysi... |
the most common disorders are depression , substance abuse , disturbance of attention , and eating disorders .
it is defined by who as a state of well - being in which every individual realizes his or her own potential , can cope with the normal stresses of life , can work productively and fruitfully , and is able to... | while developing mental health work in schools , it is very important to consider the viewpoint of pupils .
parents can also give remarkable information on their children 's viewpoint .
the purpose of this study was to produce a description of the concepts used by schoolchildren aged 1216 years and their families a... |
integrins are heterodimeric membrane receptors that mediate cell adhesion to ecm or to another cell ( hynes , 2002 ) .
ligand binding provides transmembrane mechanical links to transmit forces from extracellular contacts to intracellular structures ( e.g. , the cytoskeleton ) and signals for a wide variety of cellula... | binding of integrins to ligands provides anchorage and signals for the cell , making them prime candidates for mechanosensing molecules .
how force regulates integrin ligand dissociation is unclear .
we used atomic force microscopy to measure the force - dependent lifetimes of single bonds between a fibronectin fr... |
herpes simplex virus ( hsv ) is the most common cause of infectious esophagitis after candidiasis .
herpes simplex esophagitis ( hse ) in immunocompromised hosts is well documented in the literature , particularly among those diagnosed with human immunodeficiency virus ( hiv ) infection .
however , rare cases have ... | herpes simplex esophagitis ( hse ) has rarely been reported in immunocompetent individuals . in a search of medline until october 2012 , we found only one case of hse in a pregnant female .
we present the first case of hse in a healthy 36-year - old female at 27 weeks gestation who recovered without antiviral therapy... |
families are regarded as a crucial part of specialized childcare during illness ( 1 ) .
the concept of family - centered care includes the values of individuality , flexibility , cultural competence , and partnership with families ( 2 ) .
the involvement of family members carries particular weight in pediatric care... | introduction : family - centered care sustains the unity of the child s and the family s health . the aim of this study was to determine nurses attitudes toward parents participation in the care of their hospitalized children in iran in 2015.methods:in this experimental study , 200 pediatric nurses from hospitals affil... |
these patients can have associated urethrovaginal or vesicovaginal fistula , requiring early or delayed surgical repair .
spontaneous closure of the fistula associated with obstetric or gynecological injury has been described in the literature . to the best of our knowledge ,
a 45-year - old female sustained pelvic... | female urethral injury following pelvic fracture is a rare entity . due to the absence of large series , management guidelines are still not standardized .
patients can have associated urethrovaginal or vesicovaginal fistula , management of which poses a major challenge to the reconstructive urologist .
spontaneous... |
nephrotic syndrome is a heterogeneous group of childhood disorders associated with proteinuria , hypoalbuminaemia , oedema and failure to thrive , and is usually managed by glucocorticoid treatment .
between 10% and 20% of the patients fail to respond to this therapy and are diagnosed with steroid - resistant nephrot... | we report the case of a paediatric patient with steroid - resistant nephrotic syndrome due to a novel dominant wilms tumour 1 mutation .
the nucleotide change c1184a , identified in exon 9 , results in amino acid substitution ser395tyr .
genotyping of parents and healthy controls indicated that this is a de novo mu... |
the nonenzymatic replication
and transmission of genetic information
may have played an important role in the transition from prebiotic
chemistry to cellular life by enabling the evolution of selectively
advantageous ribozyme catalysts prior to the emergence of ribozyme
rna polymerases .
the chemistry of no... | the
nonenzymatic replication of rna oligonucleotides is thought
to have played a key role in the origin of life prior to the evolution
of ribozyme - catalyzed rna replication .
although the copying of oligo - c
templates by 2-methylimidazole - activated g monomers can be quite efficient ,
the copying of mix... |
cell behavior is regulated by numerous distinct cues that impinge on them in vivo . alongside chemical gradients
geard and willadsen , 2009 ; niehrs , 2010 ; ben - zvi et al . , 2011 ; gershenson , 2012 ) and physical forces ( beloussov and grabovsky , 2006 ; beloussov , 2008 ; nelson , 2009 ; von dassow and davidso... | in addition to biochemical gradients and transcriptional networks , cell behavior is regulated by endogenous bioelectrical cues originating in the activity of ion channels and pumps , operating in a wide variety of cell types .
instructive signals mediated by changes in resting potential control proliferation , diffe... |
type 2 diabetes mellitus ( t2 dm ) is the most common endocrine disorder and its incidence
is increasing worldwide .
this condition is a serious public health concern due to the
need for lifelong care , premature death and the fact that it remains incurable .
insulin resistance , whereby target tissues do
not... | diabetes has been associated with periodontitis , but the mechanisms through which
periodontal diseases affect the metabolic control remain unclear.objective this study aimed to evaluate serum leveis of inflammatory markers , il-8 , il-6 and
monocyte chemoattractant protein 1 ( mcp-1 ) , in type 2 diabetic patients... |
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\begin{d... |
a 28-year - old man presented with swelling and redness on the right inguinal and buttock area of two weeks duration .
initial laboratory findings showed elevated esr ( 66 mm / hr ) and crp ( 15.4 mg / dl ) levels .
mri was performed to identify the infection focus and guide treatment planning , and showed a thin -... | the authors report two cases with distension of the obturator internus bursa identified on mr images , and describe the location and characteristic features of obturator internus bursitis ; the " boomerang "- shaped fluid distension between the obturator internus tendon and the posterior grooved surface of the ischium ... |
a pandemic caused by the new influenza a ( h1n1/09 ) virus resurged in march 2009 .
this new virus is a quadruple - reassortant influenza a virus composed of human , swine and avian strains .
clinical disease generally appears mild , but complications can occur , especially in those with underlying disease , pregna... | the pandemic new influenza a ( h1n1/09 ) virus may be especially threatening for immunosuppressed renal transplant patients as they are at increased risk for complications , prolonged infection and mortality .
this is the first case report of renal transplant patients with pcr - confirmed h1n1 respiratory tract infec... |
the trypanosomatids trypanosoma cruzi , trypanosoma brucei , and leishmania major are the causative agents of chagas disease , african sleeping sickness and leishmaniasis , respectively .
these protozoan pathogens affect over 27 million people , primarily in developing countries within tropical and subtropical region... | a wide variety of dna lesions arise due to environmental agents , normal cellular metabolism , or intrinsic weaknesses in the chemical bonds of dna .
diverse cellular mechanisms have evolved to maintain genome stability , including mechanisms to repair damaged dna , to avoid the incorporation of modified nucleotides ... |
verruca vulgaris is caused by a human papillomavirus ( hpv ) infection of the epidermis .
verruca in the external auditory canal ( eac ) has rarely been reported . a previous case report introduced surgical excision for verruca treatment because there was no available nonsurgical treatment for verruca in the eac .
... | verruca vulgaris is caused by human papillomavirus ( hpv ) infections .
verruca in the external auditory canal ( eac ) has rarely been reported . a previous case report introduced surgical excision as a treatment for verruca in the eac .
we present a case of verruca vulgaris in both eacs that was successfully treat... |
italy has recently ratified the framework convention on tobacco control ( fctc ) , approved by world health assembly ( wha ) in 2003 , and was among first countries to promote a smoke free society implementing effective strategies for smoking prevention . in italy , as in all developed countries , cigarette smoking i... | this retrospective study aims to evaluate epidemiologic characteristics of patients attending stop smoking courses , based on group therapy , testing their influence on smoking cessation in univariate and multivariate model .
a total of 123 patients were included in this study .
mean age was 53 ( 11 ) .
sixty - s... |
the alterations in plasma lipids related to obesity that contribute to the higher incidence of cardiovascular disease in obese subjects mainly involve hypertriglyceridemia1,2 and low serum high - density lipoprotein ( hdl ) cholesterol .
increases in low - density lipoprotein ( ldl ) cholesterol levels are less frequ... | introduction : obesity increases triglyceride levels and decreases high - density lipoprotein concentrations in plasma . artificial emulsions resembling lipidic plasma lipoprotein structures
have been used to evaluate low - density lipoprotein metabolism . in grade iii obesity , low density lipoprotein metabolism is ... |
arginine vasopressin ( avp ) is an antidiuretic hormone produced in the hypothalamus and stored in the posterior pituitary gland 1 .
avp acts principally on renal collecting tubules to increase water reabsorption through stimulating v2 vasopressin receptors and also has direct roles in regulating cardiovascular funct... | key clinical messagecentral diabetes insipidus ( cdi ) results from a deficiency of arginine vasopressin ( avp ) secretion .
it is treated by replacement therapy with the synthetic avp analogue desmopressin . to prevent heart failure in patients with cdi accompanied by cardiac dysfunction ,
controlling sodium and w... |
carotid atherosclerosis is a progressive , multifactorial artery disease , associated with high risks of morbidity and mortality .
several underlying environmental and modifiable factors , such as increased , elevated systolic blood pressure ( sbp ) , dyslipidemia , smoking , and increased body mass index ( bmi ) , p... | objective .
altered calcium homeostasis has been linked to increased intima - media thickness ( imt ) and plaques .
we aimed to investigate whether serum 25-hydroxyvitamin d ( 25(oh)d ) and serum calcium are associated with imt and plaques in nonsmoking population .
methods .
ultrasound of the right carotid art... |
enzymatic catalysis , defined as the degree
to which an enzyme is
able to accelerate the rate of a given chemical reaction , remains to be fully understood .
enzymes are able
to achieve rate enhancements in the range of 1010 in comparison to uncatalyzed reactions , exceeding those of any artificial catalysts by... | how
evolution has affected enzyme function is a topic of great
interest in the field of biophysical chemistry .
evolutionary changes
from escherichia coli dihydrofolate reductase ( ecdhfr )
to human dihydrofolate reductase ( hsdhfr ) have resulted in increased
catalytic efficiency and an altered dynamic lan... |
antigen - presenting cells ( apcs ) activate t cells through a two - signal mechanism : one is initiated by t cell receptor ( tcr ) binding to antigenic peptide presented by major histocompatibility complex ( mhc ) molecules and the second signal involves costimulatory molecules that interact with costimulatory recepto... | ycp , as a kind of natural polysaccharides from the mycelium of marine filamentous fungus phoma herbarum ys4108 , has great antitumor potential via enhancement of host immune response , but little is known about the molecular mechanisms . in the present study , we mainly focused on the effects and mechanisms of ycp on ... |
metastasis to the bone is a common complication of breast , lung , prostate , gastrointestinal , haematological , melanoma , and other tumours , , . in many patients with primary breast ,
prostate and lung primary tumours , bone metastases ( bom ) are signs associated with the presence of disseminated disease .
the... | purposethis study assesses the incidence of distal bone metastases in palliative radiotherapy ( rt ) patients.material and methodsall courses of rt for bone metastases from 20072011 for patient living in british columbia ( bc ) were identified in a provincial rt programme . treated bone metastases ( bom ) were categori... |
skeletal muscle tissues are responsible for the provision of postural control , the coordination of excitation - contraction - relaxation cycles for voluntary movements , the integration of key metabolic and biochemical pathways , and the regulation of heat homeostasis . under normal physiological conditions ,
hence ... | x - linked muscular dystrophy is a highly progressive disease of childhood and characterized by primary genetic abnormalities in the dystrophin gene .
senescent mdx specimens were used for a large - scale survey of potential age - related alterations in the dystrophic phenotype , because the established mdx animal mo... |
over the last twenty years , china has achieved unprecedented economic growth , with an accompanying growth of large numbers of wealthy and middle classes , which has led to the requirement of the building of a well - off society in a comprehensive way . to this end , china is currently in the process of reforming it... | with its huge population and vast territory , china faces a great challenge in providing modern advanced health care services to all parts of the country .
the advances of information communication technologies ( icts ) and the advent of internet have revolutionised the means in the delivery of healthcare via telemed... |
atrichia congenita without ectodermal defects ( isolated form ) is a rare autosomal recessive condition characterized by the shedding of scalp hairs between one and six months of age , after which no growth occurs .
eyebrow , eyelash and body hair may also be sparse or absent ; patients may have a few pubic and axill... | atrichia congenita is a rare genodermatoses is characterized by a mutation of the human hairless ( hr ) gene on chromosome 8p22 .
there is loss of scalp hair between one to six months of age , after which no growth occurs .
eyebrow , eyelash , and body hair may also be sparse or absent ; patients may have a few pub... |
coeliac disease ( cd ) , also called gluten - sensitive enteropathy or nontropical sprue , is a unique autoimmune disorder which results from the interaction between gluten and immune , genetic and environmental factors .
originally cd was considered as a malabsorption syndrome of childhood , whereas it is now recogn... | coeliac disease ( cd ) is an autoimmune disorder which leads to chronic inflammation of the gut .
furthermore , cd is associated with upper gastrointestinal malignancies , particularly lymphoma of the small intestine .
besides lymphoma , an increased frequency of associated small bowel carcinoma has been described ... |
gaucher disease is an autosomal - recessive lysosomal storage disorder caused by mutations in the gene encoding acid beta - glucosidase ( gba1 ) .
the decreased enzymatic activity leads to accumulation of glucocerebroside within characteristic gaucher cells of mononuclear phagocyte origin identified in most tissues... | backgroundgaucher disease is a lysosomal storage disorder due to deficiency of glucocerebrosidase enzyme . in this study ,
a case of enzyme - treated woman during her pregnancy was reported.case presentationa 27-year old woman with type i gaucher disease was managed for pregnancy until delivery .
she underwent elec... |
the immune system has a complex but flexible network of cellular and molecular components to deal with the constraints of limited genetic space in responding to almost limitless types of infectious organisms , i.e. , viral , bacterial , fungal and parasitic variants .
these components are broadly divided into innate ... | differential use of cellular and molecular components shapes immune responses , but understanding of how these are regulated to promote defense and health during infections is still incomplete .
examples include signaling from members of the janus activated kinase - signal transducer and activator of transcription ( ... |
a 48-year - old female presented to the emergency department ( ed ) with syncope .
her past medical history was significant for mild mental retardation , former tobacco use , and hernia repair .
the patient stated that while cooking she felt lightheaded , subsequently lost consciousness , and fell to the ground rec... | infective endocarditis has different presentations depending on the involvement of valvular and perivalvular structures , and it is associated with high morbidity and mortality .
aortocavitary fistula is a rare complication .
we introduce the case of a 48-year - old female with native valve endocarditis , complicat... |
it is a point of convergence of the sutures between the frontal , sphenoid , parietal , and squamous temporal bones .
there are varied patterns of articulation of these bones and sometimes a small epipteric bone may be present .
there are four types of sutural pattern : sphenoparietal , the sphenoid and parietal bo... | the pterion which marks the union of 4 bones of the cranium is located superior to the zygomatic arch and posterior to the frontozygomatic suture .
it is an important neurosurgical landmark for the lateral / pterional approach and has racial differences in both its location and pattern of union of the bones .
this ... |
pregnant women are at increased risk of 2009 influenza a / h1n1 infection and its complications [ 13 ]
. the viral infection does not only cause significant maternal morbidity , but also have a negative impact on pregnancy outcome in women hospitalized because of the infection .
preterm birth rates and stillbirth h... | introduction . pandemic influenza
a / h1n1 infection during pregnancy has a negative impact on several aspects of pregnancy outcome .
as yet , no elucidating mechanism has been revealed for these effects .
we investigated whether placentas of pregnancies complicated by 2009 influenza a / h1n1 infection demonstrat... |
traf6-flag , traf6-flag ( or traf6 298522 ) , traf2flag ( or traf2 87501 ) , myd88-au1 , myd88-au1 ( or myd88 152296 ) , irak , nik(kk - aa ) , and ha - p46sapk-pcdna3 expression vectors have been described ( 8 , 18 ) .
expression vectors for nh2-terminal flag - tagged htoll and htoll ( amino acids 1666 ) wer... | the human homologue of drosophila toll ( htoll ) is a recently cloned receptor of the interleukin 1 receptor ( il-1r ) superfamily , and has been implicated in the activation of adaptive immunity .
signaling by htoll is shown to occur through sequential recruitment of the adapter molecule myd88 and the il-1r assoc... |
from march 2003 though november 2004 , admitting physicians in district and provincial hospitals within 9 provinces of thailand in the north , northeast , central , and southern regions were invited to recruit patients of all ages suspected on clinical grounds to have leptospirosis .
clinical features considered were... | we defined the positive predictive accuracy of a hospital - based clinical diagnosis of leptospirosis in 9 provinces across thailand .
of 700 suspected cases , 143 ( 20% ) were confirmed by laboratory testing .
accuracy of clinical diagnosis varied from 0% to 50% between the provinces and was highest during the rai... |
central giant cell granuloma of the jaws and giant cell tumor of long bones are well - recognized entities revealing benign nature16 .
their clinical behavior8,13,29 , prognostic factors and the histogenesis have been subject of several studies . in spite of that , these questions remain unclear
11,16,23,26
.
m... | objective : this study investigated whether some components of the extracellular matrix and cd68 expression may drive the differences between the central giant cell granuloma ( cgcg ) of the jaws and giant cell tumor ( gct ) of long bones , which present distinct evolution and clinical behavior.material and methods : e... |
dna double - stranded breaks ( dsbs ) are potentially lethal lesions if unrepaired , and their misrepair can give rise to genome instability , a hallmark of cancer ( jeggo and lavin , 2009 ) . to maintain genome stability in response to such lesions ,
cells employ either homologous recombination ( hr ) or nonhomologo... | summarymodulating chromatin through histone methylation orchestrates numerous cellular processes .
setd2-dependent trimethylation of histone h3k36 is associated with active transcription . here
, we define a role for h3k36 trimethylation in homologous recombination ( hr ) repair in human cells .
we find that depl... |
acute diarrhea still remains a leading cause of mortality and morbidity in children of the developing countries .
the appropriate management of acute childhood diarrhea consists of fluid and electrolyte therapy , suitable antibiotics ( e.g. in case of shigellosis , severe cholera , etc . ) , and adequate nutritional ... | objectivefew reports are available on some benefits , such as shortened duration of diarrhea and better weight gain , for lactose - free over lactose - containing formula in acute childhood diarrhea .
we evaluated the effects of lactose - free formula in dietary management of acute diarrhea in formula - fed children.... |
rotavirus ( rv ) is the primary etiological agent causing severe gastroenteritis ( ge ) in children . in 2008 , rv accounted for approximately 453,000 ( 420,000494,000 ) worldwide deaths and 36% of diarrheal hospitalizations among children under 5 years of age.1,2 each year , approximately 65,000 deaths can be attribut... | purposerotavirus ( rv ) is the leading cause of morbidity and mortality in children under 5 years of age worldwide .
this study assessed the role of rv as a cause of gastroenteritis ( ge)-associated hospitalization in children , generating baseline information to evaluate the potential impact of the rv vaccine in red... |
endometriosis is a common benign gynecological disease characterized by the presence of ectopic endometrial tissue outside the uterus .
it is a well - known fact that endometriosis most commonly affects such organs as the ovaries , utero - sacral ligaments , uterine tubes , pouch of douglas , and rectum .
the bladd... | background and objectives : genital endometriosis is still an unclear enigma of the female .
it occurs in approximately 20% to 35% of all women of reproductive age .
the urinary tract is seldom affected.methods:we report on a patient with bladder endometriosis with recurrent heavy pain at menstruation within the fr... |
a 5-month - old feral kitten developed worsening respiratory signs , including tachypnea , coughing and wheezing after standard anthelmintic treatment with fenbendazole at a local shelter .
the kitten was referred to the university of california , davis , william r pritchard veterinary medicine teaching hospital for ... | case summarya 5-month - old feral kitten developed worsening respiratory signs , including tachypnea , coughing and wheezing after standard anthelmintic treatment with fenbendazole at a local shelter .
the kitten was referred to the university of california , davis , william r pritchard veterinary medicine teaching h... |
tooth formation is an advancing process that is regulated by reciprocal interactions between the epithelial and mesenchymal tissues .
these interactions stimulate a subpopulation of mesenchymal cells to differentiate into odontoblasts , which , in turn , form the primary dentin .
but , after dentinal damage these p... | statement of the problem : stem cells from human exfoliated deciduous teeth ( sheds ) are a population of highly proliferative cells , being capable of differentiating into osteogenic , odontogenic , adipocytes , and neural cells .
vitamin d3 metabolites such as 1 , 25-dihydroxyvitamin d3 are key factors in the regul... |
philosophical , religious , and cultural differences in the concept of death and ways it is defined make discussions of the subject very complex .
advances in medicine and technology that have made it possible to support , repair , or replace failing organs challenge commonly held notions of life and death .
the la... | introduction and methodsthis report summarizes the results of the first phase in the development of international guidelines for death determination , focusing on the biology of death and the dying process , developed by an invitational forum of international content experts and representatives of a number of professio... |
single cell suspensions of lymph node cells and thymocytes were prepared from c57bl/6 or cd8 mice thymi .
purified populations of cd4cd8 thymocytes > 96% pure were obtained by anti - cd8 panning of whole thymocyte populations and selecting the adherent cells , as described previously 17 .
cells ( 0.53 10 , as indi... | linker for activation of t cells ( lat ) is an adaptor protein whose tyrosine phosphorylation is critical for transduction of the t cell receptor ( tcr ) signal .
lat phosphorylation is accomplished by the protein tyrosine kinase zap-70 , but it is not at all clear how lat ( which is not associated with the tcr ) enc... |
recently , the number of laparoendoscopic single - site surgery ( less ) procedures performed has increased because of advancements in surgical instrumentation , cosmetic considerations and trends toward minimal invasiveness.1 the less procedure was developed due to the unique characteristics of the umbilicus , ie , it... | objectiveto compare the operative outcomes , postoperative pain , and subsequent convalescence after laparoendoscopic single - site surgery ( less ) or conventional laparoscopic surgery for adnexal preservation.study designfrom december 2009 to september 2010 , 63 patients underwent less ( n = 33 ) or a conventional la... |
a significant association between n - ras oncogene activating point mutations and testicular cancer has recently been reported .
we have studied dna samples from the blood and fresh tumor tissues of 17 norwegian testicular cancer patients ( 11 seminomas/6 nonseminomas ) .
point mutations in k - ras-2 and n - ras ex... | |
in coronary artery bypass grafting surgery ( cabgs ) , the vessels that must be used are internal mammary arteries ( i m a ) and saphenous veins ( sv ) ; however , svs present a greater risk of occlusion .
nitric oxide ( no ) could be involved in the improvement of sv graft patency rates [ 2 , 3 ] since no plays a pi... | objective . to evaluate the impact of oxidative stress on vascular reactivity to vasoconstrictors and on nitric oxide ( no ) bioavailability in saphenous vein ( sv ) graft with endothelial dysfunction from hypertensive patients ( ht )
. methods .
endothelial function , vascular reactivity , oxidative state , nitrit... |
streptococcus pyogenes is the major causative agent for pharyngitis and tonsillitis , but may also cause , although relatively rarely , invasive infections such as meningitis , sepsis , and necrotizing fasciitis . for such infections , treatment with antimicrobial agents exhibiting superior activity against s. pyogenes... | minimal inhibitory concentrations ( mics ) and minimal bactericidal concentrations ( mbcs ) of various antimicrobial agents were measured against 12 strains of streptococcus pyogenes isolated from children with invasive infections between 2003 and 2012 .
the patients ranged in age from 1 day to 15 years , with pati... |
clear cell adenocarcinoma of the urethra ( ccau ) is rare in both sexes but has been more commonly described in the female urethra . even in the female ccau is very rare .
information regarding ccau has been obtained from single case reports and small case series [ 1 , 2 ] .
the ensuing paper contains a review of t... | background .
clear cell adenocarcinoma of the urethra ( ccau ) is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour . aims . to review the literature on ccau
. methods .
various internet databases were used .
results / literature review .
( i ) ccau occurs... |
a 39-year - old male with medical history of gastric bypass surgery and chronic alcoholism was admitted for a syncopal episode .
previously , the patient underwent roux - en - y gastric bypass in 2008 after failed lifestyle modifications in effort to reduce body weight . additionally , in the last two and half years ... | acquired adult - onset zinc deficiency is occasionally reported in patients with malnutrition states , such as alcoholism , or malabsorptive states , such as post - bariatric surgery .
the defining symptoms of hypozincemia include a classic triad of necrolytic dermatitis , diffuse alopecia , and diarrhea .
we repor... |
-amyloid ( a ) peptide is the main cause of alzheimer 's disease ( ad ) [ 1 , 2 ] .
a has two major types , a40 and a42 , which are derived from a ubiquitous type i transmembrane protein
amyloid precursor protein ( app ) by a two - step secretase ( - and -secretase ) pathway [ 35 ] .
the amyloid cascade hypothesi... | the neurotoxicity of a is associated with the formation of free radical by interacting with redox active metals such as cu2 + .
however , the relationship between ion - interaction , ion - driven free radical formation , and a conformation remains to be further elucidated . in the present study , we investigated the ... |
despite differing estimates , about 4 - 8% of the population in india are differently abled .
one in every 10 children is born with or acquires a physical , mental or sensory disability .
these translate into 40 - 90 million children 's , which is a substantial number .
only 35.29% of all people living with disab... | background : persons with disabilities comprise at least 4 to 8 percent of the indian population .
children with disabilities in india are subject to multiple deprivations and limited opportunities in several dimensions of their lives . their families and caregivers also go through lot of stress and challenges in hav... |
mixed cortical cell cultures containing both glia and neurons , were prepared from icr mouse brains at 15 - 16 days of gestation . briefly , dissociated neocortical cells ( 3.510 cells / well ) were plated onto primaria - coated 24-well plates ( falcon ) containing a glial bed in plating medium consisting of eagle 's m... | recently , loss of endogenous glutathione during n - methyl - d - aspartate ( nmda ) receptor - mediated excitotoxic injury , and the resultant overproduction of reactive oxygen species ( ros ) through an arachidonic acid cascade process in brain , have been implicated in neuronal damage in various neurodegenerative di... |
maxillofacial trauma represents one of the greatest challenges to public health services worldwide , because of their high incidence and significant financial cost .
they are often associated with morbidity and varying degrees of physical , functional , and esthetic damage .
the road traffic accidents ( rtas ) are ... | introduction : the incidence of maxillofacial injuries is on the rise due to motor vehicle accidents and increased incidence of violence in recent times .
the aim of this retrospective study was to determine the incidence , etiology , and the pattern of fractures in the maxillofacial region.materials and methods : af... |
improvement in the standard of living and changes in diet have led to an increase in the
prevalence of hypertension , arteriosclerosis , and diabetes mellitus . moreover ,
cerebrovascular diseases are
the second - highest cause of death , followed by cancer , in korea1 . among the cerebrovascular diseases ,
the... | [ purpose ] the purpose of this study was to examine the effects of transcranial direct
current stimulation ( tdcs ) applied to the cerebral cortex motor area on the upper
extremity functions of hemiplegic patients .
[ subjects and methods ] twenty four patients
with hemiplegia resulting from a stroke were divi... |
a body mass index ( bmi ) of 30 or greater is defined as obesity with a bmi less than 35 classified as grade 1 obesity , bmi equal to or greater than 35 but less than 40 classified as grade 2 obesity , whereas a bmi 40 categorized as grade 3 obesity . the risk of coronary heart disease , stroke , diabetes , and cancer ... | objectives : the aim of this research was to study the socio - demographic and behavioral determinants of obesity and body mass index ( bmi ) in the united states , using a nationally representative sample.methods:we used data from the 2010 us national health interview survey .
analyses were limited to adults 18 year... |
all aspects of the study were conducted in accordance with the declaration of helsinki and received a favorable ethical opinion from the surrey research ethics committee and the university of surrey ethics committee .
they then attended a prescreening session at the university of surrey , typically within 1 month of ... | objectiveprevious animal studies suggest a functional relationship between metabolism , type 2 diabetes , and the amplitude of daily rhythms in white adipose tissue ( wat ) .
however , data interpretation is confounded by differences in genetic background and diet or limited sampling points .
we have taken the nove... |
an aortoenteric fistula ( aef ) is a rare but life - threatening cause of gastrointestinal ( gi ) bleeding .
patients with an aef are commonly encountered as a medical emergency associated with acute gi bleeding .
although the reported incidence of aef is low , immediate recognition and management is essential for ... | in order to establish optimal management for aortoenteric fistula ( aef ) the records of five patients treated for aef ( four aortoduodenal and one aortogastric fistula ) were retrospectively reviewed .
the arterial reconstruction procedures were selected according to the surgical findings , underlying cause , and pa... |
the widely used 450k dna methylation array ( infinium humanmethylation450 beadchip ) includes 485,577 cytosine positions in human dna distributed among all 22 autosomal and 1 sex chromosome pair .
when correlated to rna transcripts , 74.4% of cpgs correspond to coding messenger rna genes , 0.85% are associated to non... | aim : dna methylation is the best known epigenetic mark .
cancer and other pathologies show an altered dna methylome .
however , delivering complete dna methylation maps is compromised by the price and labor - intensive interpretation of single nucleotide methods.material & methods : following the success of the hu... |
rheumatoid factors ( rfs ) , a class of immunoglobulins ( igs ) that have different isotypes and affinities , were first detected more than 70 years ago , but there is still much to discover about the mechanisms underlying their production , physiological role , and pathological effects .
waaler described an antibody... | rheumatoid factors are antibodies directed against the fc region of immunoglobulin g. first detected in patients with rheumatoid arthritis 70 years ago , they can also be found in patients with other autoimmune and nonautoimmune conditions , as well as in healthy subjects .
rheumatoid factors form part of the workup ... |
primary biliary cirrhosis ( pbc ) is a chronic cholestatic liver disease recognized at histology as chronic nonsuppurative destructive cholangitis with an autoimmune pathogenesis supported by th1 or th17 cells producing ifn- or il-17 [ 1 , 2 ] .
several inflammatory cell populations , including t and b cells , are fo... | primary biliary cirrhosis ( pbc ) is characterized by the autoimmune injury of small intrahepatic bile duct . on this basis
, it has been suggested that the targeted biliary epithelial cells ( bec ) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion . to address... |
periodontitis is a multifactorial disease caused by the presence of periodontopathogenic species in a susceptible host and this susceptibility maybe influenced by environmental and genetic factors .
the most important goal of periodontal therapy is to reduce or eliminate the sub gingival microorganisms , which cause ... | background : the purpose of this study was to clinically evaluate the benefits of sub gingival chlorhexidine ( chx ) varnish and biodegradable chx chip application used as an adjunct to scaling and root planning ( srp ) as combined therapy and also to compare the effect of combined therapy with srp alone.materials and ... |
decays of b mesons to two - body final states containing a charmonium resonance such as a j/ or (2s ) offer a powerful way of studying electroweak transitions .
such decays probe charmonium properties and play a role in the study of cp violation and mixing in the neutral b system .
the relative branching fraction... | the relative rates of b - meson decays into j/ and (2s ) mesons are measured for the three decay modes in pp collisions recorded with the lhcb detector .
the ratios of branching fractions ( \documentclass[12pt]{minimal }
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\usepackage{amsfonts }
\usepa... |
physical activity ( pa ) has been identified as a hallmark contributor to individuals ' quality of life , most notably among women .
indeed , several research endeavours have converged on trying to understand the principal determinants of pa , and in particular , those factors that can be associated with individuals ... | there is evidence that affective experiences surrounding physical activity can contribute to the proper self - regulation of an active lifestyle .
motivation toward physical activity , as portrayed by self - determination theory , has been linked to positive affect , as has the intensity of physical activity , especi... |
ingestion of some amino acids has presumable roles in performance improvement in athletes.[13 ] among them , -alanine supplementation has been suggested to improve performance during high - intensity exercises . on the other hand
, it has been shown that large amounts of h are produced in the muscles during high - in... | objectives : supplementation with -alanine has been proposed to improve performance in some exercises such as cycling and running .
also , it has been demonstrated that great deals of proton ions are produced in the skeletal muscles during exercise that result in acidosis , whereas -alanine may reduce this effect .
... |
this study supports the main characteristics of a new genus pygmaiobacter and a new species
pygmaiobacter massiliensis strain marseille - p3336 ( csur p3336 ) ; that was isolated from a stool sample of a healthy 47-year - old pygmy woman.the institut fdratif de recherche ethics committee , gave approval for this stu... | |
in india among the urban women , the numbers of breast cancer patients were increasing annually , both to aging of the population and increase in age - specific incidences .
case control studies in mumbai and chennai have identified the factors such as null parity , late age at marriage , and late age at first pregna... | breast cancer is a leading cause of death in women worldwide both in the developed and developing countries .
thus effective treatment of breast cancer with potential antitumour drugs is important . in this
paper , human breast cancer cell line mcf-7 has been employed to evaluate the antiproliferative activity of r... |
a 64-year - old male who suffered from osteoarthritis of the right knee underwent a uka ( biomet , swindon , uk ) on the right knee . preexisting
however , 4 months postoperatively , he began to feel a painful snapping sensation on the posteromedial side , particularly when he rose from a chair after prolonged sittin... | snapping pes syndrome is defined as a snapping sensation in the medial knee caused by pes anserinus and rarely occurs .
snapping pes syndrome after unicompartmental knee arthroplasty ( uka ) has not been reported yet .
we experienced two cases with this syndrome after uka .
conservative treatment was effective in... |
retrograde nailing is an effective and increasingly more popular method of distal femoral fracture fixation1 - 4 ) , and has been shown to produce good clinical outcomes5 - 10 ) .
however , concern remains regarding potential articular damage and angular deformities for comminuted or incompletely reduced fractures11 ... | purposeto identify the effects of using a ti - ni shape memory alloy ring shaped bone fixator ( sma - rbf ) during the retrograde nailing of supracondylar femoral fractures.materials and methodsthe authors reviewed 25 patients with a supracondylar femoral fracture treated by retrograde intramedullary nailing with or wi... |
tumor samples were collected from 505 consecutive lung adenocarcinoma patients who underwent curative surgical resection at seoul national university bundang hospital between may 2003 and december 2012 .
clinicopathological information and follow - up data were obtained by reviewing the medical and the pathological r... | background : aquaporin 1 ( aqp1 ) overexpression has been shown to be associated with uncontrolled cell replication , invasion , migration , and tumor metastasis . we aimed to evaluate aqp1 expression in lung adenocarcinomas and to examine its association with clinicopathological features and prognostic significance . ... |
since 1980 , when the first implantable cardiac defibrillator ( icd ) was implanted , the use of cardiovascular implantable electronic devices ( cied ) including permanent pacemaker and icd has become more popular . with growing indications ,
infectious endocarditis is a rare complication following implantation of th... | the usage of implantable cardiac defibrillator ( icd ) since 1980s is becoming more popular these days .
the rate of both , endocarditis and constrictive pericarditis are low but it still needs attention .
we are reporting a rare case of icd endocarditis as a result of toe infection in a diabetic patient .
this w... |
in the past , traditional dental luting agents such as zinc phosphate were commonly used
for cementation of crowns . in spite
of disadvantages , such as solubility , lack of retention and low ph ,
this luting agent has been successfully
used and was the most
researched cement for over a century . nowadays , s... | the need to develop new dental luting agents in order to improve the success of
treatments has greatly motivated research.objectivethe aim of this study was to evaluate the diametral tensile strength ( dts )
and film thickness ( ft ) of an experimental dental luting agent derived from castor
oil ( cop ) with or w... |
many epidemiological studies have shown that regular flavonoid rich fruit intake is associated with delayed parkinson 's disease ( pd ) , alzheimer 's disease ( ad ) , ischemic diseases and aging effects ( ono et al . , 2003 ; savaskan et al . , 2003 ; marambaud et al . , 2005 ;
data from in vitro and animal studies ... | recent clinical research has demonstrated that berry fruits can prevent age - related neurodegenerative diseases and improve motor and cognitive functions .
the berry fruits are also capable of modulating signaling pathways involved in inflammation , cell survival , neurotransmission and enhancing neuroplasticity .
... |
ovarian cancer is a highly fatal gynecologic cancer and the fifth leading cause of cancer mortality in women , with 14,030 deaths occurring in the united states per year ( 1 ) . in korea ,
ovarian cancer is the ninth leading cause of death with an age - standardized cancer mortality rate of 2.3 per 100,000 women d... | controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in asia .
this study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer ( eoc ) using asian body mass index ( bmi ) criteria .
the medical records of patients undergoing sur... |
subfoveal choroidal neovascularization ( cnv ) is a leading cause of visual loss in the geriatric population .
peripapillary cnv membranes ( ppcnvm ) have been associated with multiple etiologies [ 2 , 3 ] .
while ppcnvm , associated with optic nerve head drusen ( onhd ) , is a well - described entity in the pediat... | optic nerve head drusen can be associated with peripapillary choroidal neovascularization , in both the pediatric and adult population .
these membranes can involve the macula , causing significant visual loss . herein , we present a case that required treatment with an anti - vegf agent .
the patient failed to res... |
yttria tetragonal zirconia polycrystal ( y - tzp ) ceramics serve as an upcoming material for engineering applications and are also considered important for restoration medicine .
the excellent mechanical characteristics such as high strength and fracture resistance are attributed to the ceramic 's unique ability kno... | the effects of ceo2 addition on the sintering behavior and mechanical properties of y - tzp have been investigated over a wide sintering regime by pressureless sintering .
it has been revealed that small additions of ceo2 ( 0.31.0 wt% ) to y - tzp were beneficial in enhancing the mechanical properties and hydrotherm... |
transcranial magnetic stimulation ( tms ) and transcranial direct current stimulation ( tdcs ) are non - invasive brain stimulation techniques that , by means of magnetic fields and low intensity electrical current , respectively , aim to interefere with and modulate cortical excitability , at the level of dorsolateral... | |
metabolism lies in the heart of cell biology . understanding how cancer cells cope with metabolic needs for their unique biology
it began with the landmark observation reported more than 80 years ago by otto warburg that cancer cells consumed more glucose and produced a large amount of lactate even in a well - oxygen... | aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells , owing to its ability to divert glucose metabolites from atp production towards the synthesis of cellular building blocks ( nucleotides , amino acids , and lipids ) to meet the demands of proliferation .
the m2 isoform of pyruvate kinase (... |
relapsing polychondritis ( rp ) is an uncommon disorder of unknown etiology that is characterized by recurrent and progressive inflammation of cartilaginous structures .
a minority of patients with rp develop central nervous system ( cns ) manifestations , and limbic encephalitis has also been reported .
glucocorti... | abstractcentral nervous system ( cns ) manifestations are rare complications of relapsing polychondritis ( rp ) .
the majority of patients respond well to glucocorticoid therapy , but need to maintain it .
some patients are refractory to initial glucocorticoid therapy and to additional immunosuppressants , and end ... |
during the late 1970s and early 1980s , the lack of commercial development for drugs that treat rare diseases became an important political issue in the us . these so - called
orphan drugs were largely neglected by the pharmaceutical industry because they represented small markets that were unlikely to be profitable ... | advances in pharmacogenomic research and increasing industry interest in personalized medicine have important implications for the way that orphan drug policies are interpreted and applied .
concerns have been raised about the potential impact of pharmacogenomics and new genomic technologies on our understanding of h... |
nod / ltj female mice were purchased from charles river ( calco , italy ) .
animal care procedures were performed according to protocols approved by the hospital san raffaele institutional animal care and use committee ( iacuc no .
blood glucose was measured in the morning three times a week using a glucometer asce... | objectivenon fc - binding anti - cd3specific antibodies represent a promising therapy for preserving c - peptide production in subjects with recent - onset type 1 diabetes
. however , the mechanisms by which anti - cd3 exerts its beneficial effect are still poorly understood , and it is questionable whether this the... |
zinc is an essential element in the
nutrition of animals , human beings , and plants [ 1 , 2 ] .
zinc plays an important role in replications , gene expressions , and the metabolism of
nucleic acids and different proteins
there are many methods for
zinc determination such as spectrophotometry
[ 35 ] , atomi... | a simple , sensitive , reliable and flexible flow injection spectrophotometric method is proposed for on - line preconcentration and determination of trace amounts of zinc in water . at the presence of tween-80 in ph 9.3
buffer solutions , the shade of color of zn ( ii)-pan complex is in a linear relation to the zinc... |
noise is one of the physical factors in industries , and , today , more attention is being paid to its harmful effects . after smoking and air pollution , noise pollution
world health organization ( who ) also considers noise as the third dangerous pollutant of megacities .
moreover , damage to the hearing system ,... | background and objectives .
this study aimed to investigate the effect of noise exposure on blood pressure and heart rate of steel industry workers . materials and methods . in the present cross - sectional study ,
50 workers were selected from a steel company in fars province , iran , and exposed to 85 , 95 , and ... |
for many years , the identity of components of microtubule - organizing centers ( mtocs ) that nucleate microtubule assembly and establish microtubule polarity was a central unanswered question in the field of mitosis and the cytoskeleton .
the discovery of -tubulin ( oakley and oakley , 1989 ) , the key finding that... | tremendous progress has been made in understanding the functions of -tubulin and , in particular , its role in microtubule nucleation since the publication of its discovery in 1989 .
the structure of -tubulin has been determined , and the components of -tubulin complexes have been identified .
significant progress ... |
although uncommon in pregnancy , liver disease may cause a significant risk for the mother and fetus .
liver diseases presenting during pregnancy are usually specific to pregnancy including preeclampsia , hellp syndrome ( haemolysis , elevated liver enzymes , low platelets ) , obstetric cholestasis , hyperemesis grav... | primary sclerosing cholangitis is a progressive disease , and coincidentally in pregnancy it is rare .
it is characterized by progressive inflammation and destruction of bile ducts finally resulting in liver failure .
a rare case of primary sclerosing cholangitis in pregnancy is presented .
the course of the preg... |
genitourinary involvement causes untoward symptoms of atrophic vaginitis including dryness , burning , dyspareunia , vulvar pruritus , and discharge .
these symptoms are localized , affect up to 50% of postmenopausal women , and significantly reduce their quality of life .
for this reason , many investigations have... | background : atrophic vaginitis is a disease , which affects up to 50% of postmenopausal women .
this study compared the effectiveness and user - friendliness of vagifem ( an estradiol vaginal tablet ) and vaginal estrogen cream in the treatment of atrophic vaginitis.materials and methods : one hundred and sixty post... |
there is a plethora of tools that focus in proteomics sequence analysis , alignment and visualization but there are few examples for web servers and other software tools dedicated to peptide analysis .
there are three major classes where the tools for peptide analysis can be classified : ( i ) the peptide / protein i... | peptides , either as protein fragments or as naturally occurring entities are characterized by their sequence and function features .
many times the researchers need to massively manage peptide lists concerning protein identification , biomarker discovery , bioactivity , immune response or other functionalities .
w... |
although not the most prevalent of human malignancies , a unique combination of physiology , anatomy and biology leads to an extremely poor prognosis for all but a few patients diagnosed with pancreatic ductal adenocarcinoma ( pdac ) .
pancreatic cancer is known for its early metastasis and aggressive invasion of sur... | pancreatic cancer is one of the most devastating forms of human cancer .
the lack of effective clinical treatments for pancreatic cancer has led to one of the lowest five - year survival rates among all cancers .
recently , our laboratory has developed a novel series of isoprenylated coumarin derivatives that have ... |
helicases are enzymes that separate in an energy - dependent manner stretches of duplexed dna and/or rna into single - stranded components . currently , based on characteristic motifs and the sequence comparisons , three superfamilies ( sf1 through 3 ) and two smaller families ( f4 , f5 ) of helicases have been identif... | viruses are replication competent genomes which are relatively gene - poor .
even the largest viruses ( i.e. herpesviruses ) encode only slightly > 200 open reading frames ( orfs ) .
however , because viruses replicate obligatorily inside cells , and considering that evolution may be driven by a principle of econom... |
one of the major risk factors for the development of coronary heart disease is high low - density lipoprotein ( ldl ) cholesterol .
ldl is a lipoprotein made up of outer phospholipids , apolipoproteins , free cholesterol and inner triglycerides ( tgs ) and cholesterol ester .
-quantification is the standard method ... | background : one of the risk factors for the development of coronary heart disease is high low - density lipoprotein ( ldl ) cholesterol levels .
national cholesterol education program atp iii guidelines suggest drug therapy to be considered at ldl - cholesterol levels > 130 mg / dl .
this makes accurate reporting ... |
heavy metal toxicity due to occupational and domestic exposures raises apprehension over their potential effects on human health and the environment .
chronic arsenic toxicity , also known as arsenicosis , is a global health problem affecting millions of people and mainly caused by drinking of arsenic - contaminated ... | background : arsenic toxicity is a major global health problem and exposure via contaminated drinking water has been associated with hematological and other systemic disorders .
the present investigation has been conducted in adult male rats to evaluate the protective ability of -lipoic acid ( ala ) against such hema... |
cultures , susceptibility testing and dna extraction - one hundred and
eight cultures had previously been tested for drug susceptibility using the ogawa - kudoh
standard proportion method ( canetti et al .
1963 )
at the central laboratory of rio grande do sul ( ipb / lacen - rs ) , the regional reference
labo... | drug - resistant tuberculosis ( tb ) threatens global tb control and is a major public
health concern in several countries .
we therefore developed a multiplex assay
( line - tb / mdr ) that is able to identify the most frequent mutations related to
rifampicin ( rmp ) and isoniazid ( inh ) resistance .
the as... |
radiographers understand the importance of getting the most diagnostic information from as few radiographs as possible . in the world of pediatric scoliosis imaging , pediatric orthopedic surgeons , radiologists and orthotists must obtain more than just spine data from each and every radiograph .
scoliosis is a later... | background : whole spine scanography ( wss ) is a radiologic examination that requires whole body x - ray exposure .
consequently , the amount of patient radiation exposure is higher than the radiation dose following routine x - ray examination.objectives:several studies have evaluated the patient effective dose ( ed... |
in the last few decades , computer simulation has become an important tool to investigate various phenomena in cardiac biology , including studies of single ion channel properties , action potentials of the myocyte [ 3 , 5 ] , dynamics of action potential propagation in tissue , subcellular calcium dynamics , etc . in ... | in this technical note we show the promise of using graphic processing units ( gpus ) to accelerate simulations of electrical wave propagation in cardiac tissue , one of the more demanding computational problems in cardiology .
we have found that the computational speed of two - dimensional ( 2d ) tissue simulations ... |
ebus echobronchoscopy is a relatively recent examination method , introduced in clinical practice in 1992 .
it is a combination of echography and bronchoscopy , allowing the physician to directly examine the tumors and adenopathies situated next to the airways , both extrabronchial and extratracheal ones , inaccessi... | background and aimendobronchial ultrasound ( ebus ) is a recent minimally invasive , safe examination method for the mediastinum , with a good diagnostic precision.this method makes possible real time examination with transbronchial fine needle aspiration , diagnostic transbronchial needle aspiration ( tbna ) and stagi... |
there is some evidence that proliferation of pleural mesothelial cells ( mc ) occurs soon after deposition of asbestos fibers . to study this effect
, we instilled a single dose of 0.1 mg crocidolite into the lungs of mice for 1 and 6 weeks and counted labeled nuclei after 3h - thymidine ( 3ht ) injection .
short f... | |
snake bite was added to the world health organization ( who ) neglected list of tropical diseases in 2009 .
an estimated 5.5 million people are bitten by snakes per year resulting in 400,000 amputations and between 20,000 and 125,000 deaths annually .
a relatively recent report highlighted that one of the highest b... | abstractsnake bites occur commonly in the rural areas of south africa .
hospitals where snake bites are uncommon should always have protocols on standby in the event of such cases presenting .
this is the first reported case documenting the effect of human immunodeficiency virus ( hiv ) on snake bite in south afric... |
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