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adverse reaction to metal debris ( armd ) in arthroplasty surgery of the hip is a well - known problem and has resulted in several products being withdrawn from the marketplace . complications related to the release of metal ions can be devastating for patients and represent a significant surgical challenge . altho...
adverse reaction to metal debris ( armd ) in total hip arthroplasty surgery is a well - known problem . we present the case of a unipolar hemiarthroplasty requiring revision within 18 months of insertion secondary to an adverse reaction to metal debris . this case demonstrates a rare cause for failure of a hemiarth...
type 2 diabetes ( t2 dm ) is a global public health problem and the number of affected individuals is increasing at an alarming rate [ 1 , 2 ] . the pathogenesis of t2 dm is characterized by a progressive insulin resistance with eventual insulin deficiency . both environmental and genetic factors are known to contr...
recent studies have demonstrated that the expression of mir-34a is significantly upregulated and associated with cell apoptosis in pancreatic -cell treated with palmitate . nevertheless , the underlying detailed mechanism is largely unknown . here , we showed that mir-34a was significantly induced in min6 pancreati...
neonatal diabetes mellitus ( ndm ) is a form of diabetes that is diagnosed under the age of 6 months . the most common causes of neonatal diabetes are activating mutations in the adenosine triphosphate ( atp)-sensitive potassium ( katp ) channel . this review discusses functional effects and therapy implications of...
adenosine triphosphate ( atp)-sensitive potassium ( katp ) channels in pancreatic -cells play a crucial role in insulin secretion and glucose homeostasis . these channels are composed of two subunits : a pore - forming subunit ( kir6.2 ) and a regulatory subunit ( sulphonylurea receptor-1 ) . recent studies identif...
mixed methods research uses both quantitative and qualitative data to improve understanding of a research problem beyond what is possible with either approach alone . mixed methods studies are challenging for health researchers to plan and implement due to their design complexity and difficulties related to appropria...
little is known about how to systematically integrate complex qualitative studies within the context of randomized controlled trials . a two - phase sequential explanatory mixed methods study was conducted in canada to understand how women decide to disclose intimate partner violence in emergency department settings ...
cross - sectional studies of community - residing samples revealed that 19%50% of elderly who developed dementia experienced disruptions in their sleep.13 moreover , sleep disruption appears to worsen as the disease progresses;4 it has been estimated that elderly in the later stages of dementia spend as much as 40% of ...
purposeelderly with dementia are often afflicted with sleep problems . recent studies have suggested that acupuncture may be a feasible alternative to traditional sleep medicine for treating sleep disturbance . this study investigated the effectiveness of acupuncture on sleep quality of elderly with dementia.patien...
ventriculostomy catheters , also known as external ventricular drains ( evds ) , are frequently used in neurosurgery to monitor and relief intracranial pressure . complications arising from evds include hemorrhage , misplacement , dislodgement , blockage , and , most significantly , infection , which may be complicat...
external ventricular drainage ( evd ) is frequently used in neurosurgery to drain cerebrospinal fluid in patients with raised intracranial pressure . we performed a retrospective single center study in order to evaluate the incidence of evd - related infections and to identify underlying risk factors . 246 evds wer...
malignant peripheral nerve sheath tumors ( mpnsts ) are very rare high - grade sarcomas with a poor prognosis at childhood and adolescence , and only 10%20% of mpnsts are seen in these periods.14 mpnsts often present with pain associated with mass lesions or neuronal involvement in the head neck , abdomen , chest wall...
malignant peripheral nerve sheath tumors ( mpnsts ) are rare sarcomas of children and adolescents , and they are aggressive tumors with a high rate of local recurrence . we present a 15-year - old boy with neurofibromatosis type 1 ( nf1 ) , who had a giant mpnst on the right thigh taking into account the available li...
it was a pleasure to read the report from dunham and coworkers concerning the relationship between hypocholesterolemia and outcome in patients following severe trauma . although their study involved only 28 patients , these patients were severely injured ( injury severity score 31 9 ) and they required at least 7 ...
hypocholesterolemia is an important observation following trauma . in a study of critically ill trauma patients , mean cholesterol levels were significantly lower ( 119 44 mg / dl ) than expected values ( 201 17 mg / dl ) . in patients who died , final cholesterol levels fell by 33% versus a 28% increase in survi...
cryptosporidium , a spore - forming protozoon , has been recognized as a human pathogen since 1976 . the species most frequently involved in human infections are cryptosporidium hominis , which primarily infects humans , and cryptosporidium parvum , which infects humans and animals such as cattle , although infection...
cryptosporidium has emerged as an important cause of diarrheal illness worldwide , especially amongst young children and patients with infectious or iatrogenic immune deficiencies . the authors describe a case of mild cryptosporidiosis in a well - nourished , immunocompetent , one - year - old child . rapid clinica...
in recent years , sedentary living and physical activity have become an important topic of research . sedentary lifestyle presents a significant risk factor for human health ( 13 ) . on the other hand , it was proven that habitual physical activity or exercise causes not only a reduction of the incidence of obesity...
background : sedentary lifestyle represents a growing health problem and considering that there is already a range of unhealthy habits that are marked as health risk factors and the increasing prevalence of sedentary lifestyle worldwide , we aimed to investigate association of sedentary way of living in suburb , workin...
lung parenchymal calcifications are uncommon , but may occur in numerous conditions so their main differential diagnosis should be known by the radiologist . we demonstrate a rare etiology for lung calcifications in a 87 year - old male that came to our emergency department complaining of dyspnea and was diagnosed wi...
diffuse pulmonary ossification ( dpo ) is a rarely diagnosed entity that may present with characteristic imaging features . it is listed in the differential diagnosis of lung parenchymal calcifications and should be considered by the radiologist if the appropriate findings are identified . we report a case of dpo s...
it is well known that in type 1 diabetes mellitus , optimal glycemic control is extremely important to prevent or postpone long - term complications . in general , glycemic control in children with type 1 diabetes is monitored by measuring glycated hemoglobin ( hba1c ) and self - monitoring of blood glucose ( smbg ) . ...
background : in children with type 1 diabetes , intensive diabetes management has been demonstrated to reduce long - term microvascular complications . at present , self - monitoring of blood glucose ( smbg ) by patients at home and glycated hemoglobin estimation every 3 months are used to monitor glycemic control in...
enzymes , of which structures and functions are prescribed in genes , basically mediate all metabolisms needed for the development and functions of living organisms . among the many enzymes , protein tyrosine kinases ( ptks ) are known to play key roles in intracellular signaling for the development and functions of ...
recent observations on environment - linked control of genetically prescribed signaling systems for either cell activation or cell death have been reviewed with a focus on the regulation of activities of protein tyrosine kinases ( ptks ) . the environment - linked redox reactions seem to primarily affect cell surface...
metastatic or loco - regionally advanced non - small cell lung carcinoma ( nsclc ) is one of the leading causes of death attacked with cancer in india and though treatment outcomes in advanced disease remain modest , with the paradigm shift in the approach to treatments customized treatment based on the tumor histolo...
background : platinum based doublets chemotherapy are the standard of care for metastatic or advanced non - small cell lung carcinoma . this leads to modest survival advantage and improve quality - of - life . however , patients with advanced or metastatic disease eventually present disease progression and needs se...
one concept that unites all therapeutic modalities including the surgical , medical , pharmacological , physiotherapeutic ( as well as other health professions - related ) and the psychological , is change ; specifically the valid confirmation of an improvement in a patient s health status due to intervention . this ...
the valid confirmation of a positive change ( improvement ) in a patient s health status due to intervention has been at the core of medicine and rehabilitation since their very inception as clinicians always aspired to ensure that treating their patients had led to successful outcomes both in acute and chronic conditi...
functional popliteal artery entrapment syndrome ( paes ) is an important and possibly underrecognized cause of exertional leg pain . it shares many features with other causes of exertional leg pain , and more than one condition can be present at once , confusing the clinical picture . an understanding of the typica...
functional popliteal artery entrapment syndrome ( paes ) is an important and possibly underrecognized cause of exertional leg pain ( elp ) . as it is poorly understood , it is at risk of misdiagnosis and mismanagement . the features indicative of paes are outlined , as it can share features with other causes of elp...
the cardiovascular health study ( chs ) is a national institutes of health national heart , lung , and blood institute funded , population - based longitudinal study of adults aged 65 years ( 7 ) . ( a full list of principal chs investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm . ) the...
objectiveto examine the relationship of parity with diabetes and markers of glucose homeostasis in older women.research design and methodswe used data from the female participants in the cardiovascular health study , a longitudinal cohort of adults aged 65 years . these data included an assessment of parity ( baselin...
the use of nickel - titanium ( niti ) rotary instruments for root canal system preparation has increased due to their undeniably favorable qualities ; however , unexpected fracture is an important disadvantage of these instruments [ 13 ] . controversy remains regarding the contribution of torsional fracture , fatigue...
objectives : the purpose of this study was to evaluate the resistance to fatigue failure of five different nickel - titanium rotary files in three different curved trajectories.materials and methods : a total of 150 neoniti a1 , race 25.06 , mtwo 25.06 , twisted file 25.06 and protaper next x2 files with the tip size o...
congenital hereditary endothelial dystrophy ( ched ) is a corneal dystrophy characterized by bilateral diffuse clouding of the corneas , causing impaired vision . depending on the mode of inheritance , it manifests either in infancy or young childhood with a cloudy cornea , light sensitivity , tearing , and sometimes n...
congenital hereditary endothelial dystrophy ( ched ) , presents in infancy or early childhood with bilateral clouding of corneas . this condition has previously been managed surgically with penetrating keratoplasty ( pkp ) . performing pkp in pediatric patients has its own set of difficulties . more recently , th...
adrenohepatic fusion is a relatively common condition that has been reported in the literature and explained as a result of normal aging . however , the presence of a neoplastic process in the adrenohepatic fusion is relatively uncommon , especially when it is a malignant neoplasm . here , we present a patient with a...
abstractadrenohepatic fusion is a relatively common condition that has been reported in the literature and explained as a result of normal aging . however , the presence of a neoplastic process in the adrenohepatic fusion is relatively uncommon . a 48-year - old male presented with ruq abdominal pain with findings of a...
d - amino acid oxidase ( ec 1.4.3.3 , daao ) is a flavoprotein that catalyzes the enantioselective oxidative deamination of d - amino acids to yield the corresponding -imino acids , which are spontaneously hydrolyzed to -oxoacids and ammonia . reoxidation of the reduced fad by molecular oxygen is accompanied by the r...
inhibition of recombinant d - amino acid oxidase from trigonopsis variabilis ( tvdaao ) activity in the presence of different sodium salts and potassium chloride is reported . a competitive inhibition pattern by sodium chloride was observed , and an inhibition constant value of ki = 85 mm was calculated . direct c...
the long - appreciated beneficial properties of the trifluoromethyl group in medicinal chemistry and the imperatives of green chemistry provide the impetus for the current resurgence of interest in the development of trifluoromethylation methods . the ability to produce ever more complex trifluoromethylated s...
the synthesis of a series of -trifluoromethylcyclohexanols and analogous trimethylsilyl ethers by addition of the ruppert prakash reagent to substituted cyclohexanones is presented . a method for the assignment of configuration of such compounds , of related -trifluoromethylcyclohexylamines and of quaternar...
moringa oleifera lam . found in most parts of ghana belongs to the monogenetic family moringaceae ( order brassicales ) . its nonmedical uses include use of the seeds in wastewater treatment due to their coagulant properties [ 1 , 2 ] . its medicinal uses stem from the fact that the entire plant has high protein , ...
moringa oleifera is a multipurpose plant used in ghana and most parts of africa . its high mineral , protein , and vitamins content has enabled its use as a nutraceutical and panacea for various diseases . this study aimed at measuring the micro- and macroelements content of dried moringa oleifera leaves using ener...
chronic hepatitis b ( chb ) virus ( hbv ) infection is the principal cause of cirrhosis and hepatocellular carcinoma ( hcc ) . the pathogenesis of hbv - related chronic liver disease is not well understood . however , it is clear that the immune mechanisms associated with the antiviral response are responsible for ch...
humoral immunity constitutes major defense mechanism against viral infections . however , the association of hepatic injury and b - cells population in chronic hepatitis b virus ( hbv ) carriers has not been studied well . in this study , fifty seven hepatitis b surface antigen ( hbsag ) positive and hbeag negative...
its raw or processed roots are the only organ source for clinical uses of traditional chinese medicine , and the leaves are not utilized at all . however , r. glutinosa leaves have the pharmacological effects and can nourish yin , tonify qi and kidney , and promote blood circulation . in the folk , the fresh leaves a...
although r. glutinosa roots are currently the only organ source in clinics , its leaves are a potential supplement for the roots especially in extraction of some important bioactive compounds . our early work found that the contents of catalpol and total iridoid glycosides varied among different developmental stages ...
leiomyoma , a benign smooth muscle neoplasm is classified by world health organization on the basis of histopathology into three types : 1 ) solid , 2 ) vascular ( angiomyoma , angioleiomyoma ) and 3 ) epithelioid . leiomyoma is a common neoplasm of uterus and gastrointestinal tract mostly occurring in solid variant ...
gingival angioleiomyoma are rarely encountered lesions and most of these lesions are excised in toto in view of reactive gingival epulitic lesions . however , due to the vascular nature of these lesions , many a times surgeons experience unexpected hemorrhage and require extensive hemostatic management . a preoperati...
a 36-year - old woman presented at our institution ( gachon university gil hospital ) with erythematous confluent maculopatches on her face , trunk , and palms ; jaundice ; fatigue ; pruritus ; and aggravation of skin lesions over the previous week . she had been previously diagnosed as having erythema multiforme 2 w...
a 36-year - old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice after 8 months of dapsone therapy . her symptoms had developed progressively , and a physical examination revealed bilateral cervical lymphadenopathy and splenomegaly . excisional bio...
we report a case of a female patient on aspirin and warfarin who developed a retropharyngeal haematoma following minor blunt head and neck trauma . an 84 year old woman had a mechanical fall at ground level resulting in neck hyperextension . a rigid cervical collar was applied and anterior neck and chest swelling a...
retropharyngeal haematoma is a rare and potentially fatal cause of airway obstruction . the treatment of retropharyngeal haematoma is contentious . we report a case of an 84 year old woman on aspirin and warfarin who developed a retropharyngeal haematoma following minor blunt head and neck trauma . the patient pr...
this type of infection is related , among others , to the type of the transplanted organ . invasive candidiasis occurs more often in liver recipients , and invasive aspergillosis in lung recipients [ 13 ] . invasive candidiasis is one of the main post transplant complications , presenting a high risk of death . t...
solid organ transplant recipients are at high risk of fungal infections , because of ongoing immunosuppressive treatment . there are three post organ transplant phases : early , intermediate , and late , all of them at risk of candida infections . since conventional tests are insufficient , specific secondary diagn...
asthma is a disease that is caused by inflammation in the lung and bronchus and is affected by genetic and environmental influences . aspirin - exacerbated respiratory disease ( aerd ) , which was first reported in 1922 , is a type of asthma . aerd is characterized by the following three symptoms : bronchial asthma...
the tyrosine - protein kinase tec ( tec ) is a member of non - receptor tyrosine kinases and has critical roles in cell signaling transmission , calcium mobilization , gene expression , and transformation . tec is also involved in various immune responses , such as mast cell activation . therefore , we hypothesized...
the dengue virus strains sequenced for this study as well as sequences obtained from genbank for this study are listed in table 1 . the virus isolates were obtained from the centers for disease control and prevention , dengue branch , puerto rico , and division of vector - borne infectious diseases , ft . collins ,...
over the past two decades , dengue virus serotype 3 ( denv-3 ) has caused unexpected epidemics of dengue hemorrhagic fever ( dhf ) in sri lanka , east africa , and latin america . we used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks . isolates fr...
adult attention deficit hyperactivity disorder ( adhd ) is an extremely debilitating neurodevelopmental disorder that often persists beyond childhood , affecting 2.5%5% of adults in the general population.1 it is one of the most frequent psychiatric disorders that affect the childhood population , and recent data sugge...
objectivealthough adult attention deficit hyperactivity disorder ( adhd ) often persists beyond childhood , daily clinical practices and transition of adult patients with adhd into adult mental health services in turkey are not well studied . the aim of this study was to provide data about the presentation of adult p...
with estimated 80,000 deaths among children in 2013 , tuberculosis ( tb ) continues to be major infectious disease among children . low- and middle - income countries bear disproportionate burden with more than 50% of the global cases occurring in southeast asia and the western pacific . india alone accounts for 27% ...
majority of children with tuberculosis are treated in private sector in india with no available data on management practices . the study assessed diagnostic and treatment practices related to childhood pulmonary tuberculosis among paediatricians in mumbai 's private sector in comparison with international standards f...
monocytes and macrophages , which are categorized among the leukocytes , play a pivotal role in the innate immune system [ 13 ] . their origin lies in a common myeloid precursor , while they both play important roles in innate immunity . macrophages , which are produced from monocytes after their exposure to certai...
it is well known that the innate immunity system , involving the contribution of monocytes and macrophages , may dysfunction in fetuses and preterm neonates . monocytes are capable of differentiating into dendritic cells ( dcs ) or into mucosal macrophages during certain infections and of producing inflammatory media...
emergence agitation ( ea ) was described at first by eckenhoff et al in the early 1960s . ea has been described as a dissociated state of consciousness in which the child is inconsolable , irritable , uncooperative , typically thrashing , crying , moaning or incoherent . nowadays , about 4 million children undergo ...
abstractobjectivepostanesthetic emergence agitation is a common problem in pediatric postanesthetic care unit with an incidence ranging from 10 to 80% . this study was done to determine the prevalence of emergence agitation and associated risk factors in pediatric patients who underwent general anesthesia.methodsthis...
the study included 79 obese patients undergoing weight - reducing surgery and 14 lean patients who underwent elective cholecystectomy . participants were included if they had fasting blood glucose levels < 7.0 mmol / l , no history of diabetes or use of glucose- or lipid - lowering drugs , and no weight changes > 3% ...
objectiveto assess the potential role of foxp3-expressing regulatory t cells ( tregs ) in reversing obesity - linked insulin resistance and diabetic nephropathy in rodent models and humans.research design and methodsto characterize the role of tregs in insulin resistance , human visceral adipose tissue was first evalua...
cardiac events are a leading cause of death worldwide and despite our best life support efforts outcomes after cardiac arrest are still poor . the european resuscitation council ( erc ) cardiopulmonary resuscitation ( cpr ) 2010 guidelines emphasize the importance of minimizing the interruption of chest compression t...
abstractthe aim of this study was to assess the performance of the etview vivasight sl ( etview ) single - lumen airway tube with an integrated high - resolution imaging camera in a manikin - simulated cardiopulmonary resuscitation scenario with and without chest compression.this was a randomized crossover manikin tria...
intacs ( addition technology inc , des plaines , il , usa ) are intrastromal corneal rings consisting of two thin , clear hexagonal polymethyl methacrylate segments . they are placed in surgically created semicircular channels between the stromal lamella at two - thirds the stromal depth during an outpatient procedur...
this case report describes the clinical and histopathologic features , including molecular confirmation , of fungal keratitis after intrastromal corneal ring segments placement for keratoconus . a 52-year - old woman underwent insertion of intacs corneal implants for treatment of keratoconus . extrusion of the impl...
apoptosis is a type of genetically regulated programmed cell death that controls the development of multicellular organisms and tissues by eliminating physiologically redundant , physical damaged , and abnormal cells . studies focusing on the genes and signals regulating apoptosis have played an important role in bas...
backgroundthe aim of this study was to evaluate the ability of dual acridine orange / ethidium bromide ( ao / eb ) staining to detect tumor cell apoptosis . according to apoptosis - associated changes of cell membranes during the process of apoptosis , a clear distinction is made between normal cells , early and late a...
the spect acquisition in lung perfusion scan provides higher sensitivity and specificity to detect pulmonary thromboemboli ( pte ) compared to planar imaging ( 1 , 2 ) . because of higher specificity , there are hopes that the lung perfusion spect could be interpreted without a ventilation study . the value of higher...
a 22-year - old woman presented with acute left - sided pleuritic chest pain and dyspnea 6 days after surgery for revision of the stenotic central aortopulmonary shunt . she had a history of tetralogy of fallot ( tof ) , pulmonary valve stenosis , ventricular septal defect and major aortopulmonary collateral artery ....
the primary complaint of most patients with this tumor is testicular swelling , which is usually painless . it is not uncommon for this tumor to be of an advanced stage at the time of the diagnosis , and the prognosis is dismal . although scrotal swelling is the most common manifestation , the clinical presentation...
primary adenocarcinoma of the rete testis is a rare malignant testicular tumor with a poor prognosis . here we report the case of a 54-year - old man with right hydronephrosis that was detected before the diagnosis of the primary testicular lesion . during the evaluation of the right hydronephrosis by use of abdomino...
functional fitness not only accounts for the traditional physical fitness parameters such as muscle strength , cardiorespiratory endurance , and flexibility , but also includes balance . however , it is well known that , with age , functional fitness declines , resulting in a reduced ability to perform activities such ...
the purpose of this study was to determine the effects of periodic task - specific test feedback on performance improvement in older adults undertaking community- and home - based resistance exercises ( chbre ) . fifty - two older adults ( 6583 years ) were assigned to a muscular perfsormance feedback group ( mpg , n...
participants were chinese women with a hong kong permanent identity card who were : aged 1865 years;able to read chinese or english;not pregnant . able to read chinese or english ; the study was approved by the institutional review board of the university of hong kong . a total of 379 women were recruited in a pr...
purpose : cervical cancer screening has been consistently shown to be effective in reducing the incidence rate and mortality from cervical cancer . however , cervical screening attendance rates are still far from satisfactory in many countries . strategies , health promotion and education programs need to be develope...
we report on the prevalence of different antimicrobial - drug resistance profiles among danish salmonella ser . furthermore , we show results indicating that a dt104 outbreak strain lost resistance genes by shifting to the sgi1-b variant during the outbreak . consequently , the outbreak included isolates with both th...
the prevalence of different antimicrobial resistance profiles and variants of the salmonella genomic island 1 ( sgi1 ) was reported for salmonella enterica serovar typhimurium dt104 strains isolated from patients in denmark . variation in antimicrobial resistance and corresponding changes of sgi1 were shown among iso...
the connection may occur as a result of iatrogenic causes during root canal treatment ( at the level of the floor of the cameral cavity or at different levels of the root ) or during prosthetic treatment for postcanal penetration . prognoses for perforated roots depend on the time lapsed before the perforation is sea...
the aim of this in vitro study is to compare the microleakage of a root perforation sealed with mta ( mineral trioxide aggregate ) ( group m ) to that sealed with mta following er : yag laser irradiation ( group ml ) . forty - two recently extracted human monoroot teeth were used . two cavities were prepared on eac...
in teeth with extensive coronal tissue loss , a post - and - core foundation is usually needed to retain a definitive restoration.in the past decades , a commonly employed system included a prefabricated fiber post and adhesive cement followed by core build - up . advantages of using prefabricated adhesive posts incl...
objective : the effects of closely adapting a prefabricated fiber to the post space remain unknown . the purpose of this study was to quantify the microleakages of a custom adapted fiber - reinforced post , a prefabricated quartz fiber post and a cast post using nondestructive methods.materials and methods : sixty - ...
diseases that belong to spondyloarthritides ( spa ) are frequently manifested as asymmetric peripheral arthritis of the large joints with knee involvement . tumour necrosis factor ( tnf ) inhibitors are highly effective for the treatment of peripheral arthritis in patients with ankylosing spondylitis ( as ) [ 1 , 2 ]...
our aim was to evaluate the effectiveness of tumour necrosis factor ( tnf ) inhibitors as add - on therapy for knee synovitis that did not respond to disease - modifying antirheumatic drugs ( dmards ) and other standard treatments in patients with peripheral spondyloarthritis ( spa ) . we retrospectively studied 27 s...
type 1 diabetes is an autoimmune disease resulting from destruction of pancreatic - cells by infiltrating immune cells . the nod mouse is an important model of spontaneous autoimmune diabetes that has been used to understand type 1 diabetes pathogenesis and develop therapeutics to prevent - cell destruction . sim...
immune phenotyping provides insight into disease pathogenesis and prognostic markers . trajectories from age of 4 to 36 weeks were modeled for insulin autoantibodies and for leukocyte subpopulations in peripheral blood from female nod ( n = 58 ) and nor ( n = 22 ) mice . nod mice had higher trajectories of insulin ...
lagophthalmos is defined as the inability to close the eyelids completely.1,2 orbicularis oculi muscle that closes eyelids is innervated by facial nerve ( cnvii ) . paresis of the orbicularis oculi muscle leads to diminished blink , lagophthalmos , and impairment of the nasolacrimal pumping system . lagophthalmos m...
lagophthalmos is defined as the inability to close the eyelids completely . this situation may lead to corneal problems such as epithelial defects , stromal thinning , exposure keratitis , bacterial infection , perforation , and blindness . a patient with lagophthalmos underwent insertion of a custom - made gold we...
superior mesenteric artery syndrome ( smas ) is a rare condition causing acute or chronic compression of the third part of the duodenum , due to a reduction in the aortomesenteric angle . laparoscopic duodenojejunostomy is a minimally invasive option that has been reported in up to 10 cases . we describe our operat...
background : superior mesenteric artery syndrome ( smas ) is a rare condition causing acute or chronic compression of the third part of the duodenum , due to a reduction in the aortomesenteric angle . traditionally , an open duodenojejunostomy is recommended when conservative management fails . laparoscopic duodeno...
bipolar disorder ( bd ) is a clinically severe psychiatric disorder , characterized by recurrent alternating episodes of mania and depression , with a lifetime prevalence of 0.7%6% [ 13 ] . given its high morbidity , disability , and premature mortality , bd is a major health problem with severe socioeconomic imp...
bipolar disorder ( bd ) is a chronic and often severe psychiatric illness characterized by manic and depressive episodes . among the most effective treatments , mood stabilizers represent the keystone in acute mania , depression , and maintenance treatment of bd . however , treatment response is a highly heterogeneou...
the inhibition of 1 on cell - free melan - a tyrosinase was demonstrated by a lineweaver burk plot . the results shown in figure 1 revealed both 1 and resveratrol to be noncompetitive inhibitors of tyrosinase , with kojic acid being a competitive inhibitor . thus , the addition of 1 to the reaction mixture...
2,3,5,4-tetrahydroxystilbene-2-o--d - glucopyranoside ( 1 ) , isolated from polygonum multiflorum , is a noncompetitive inhibitor of tyrosinase in cell - free kinetics ; it reduced the vmax values in a dose - dependent manner . compound 1 inhibited pka - induced melanogenesis , reduced the protein expression ...
in africa , the health impact of schistosomiasis , whether caused by schistosoma haematobium or by s. mansoni , is a well - known public health problem , one that is now receiving well - deserved attention . this attention is focused primarily on the most vulnerable part of the community , that part of the population...
schistosomes are long - lived parasites , hence schistosomiasis is a chronic disease with severe long - term implications . however , definitive diagnosis of active infection has been difficult because demonstration of infection has depended on detecting parasite eggs in urine and/or stool . in the case of schistosom...
the online version of this article ( doi:10.1007/s11032 - 015 - 0192-x ) contains supplementary material , which is available to authorized users . supplemental table 1 primer pairs used in this study ( xls 32 kb ) supplemental fig . 1 graphical genotype of a bc2f5 line ( hk114 ) used for substitution mapping o...
bacterial grain rot ( bgr ) , caused by the bacterial pathogen burkholderia glumae , is a destructive disease of rice . at anthesis , rice panicles are attacked by the pathogen , and the infection causes unfilled or aborted grains , reducing grain yield and quality . thus , increasing the level of bgr resistance is...
vigabatrin ( vgb ) is an antiepileptic drug that irreversibly inhibits brain -aminobutyric acid ( gaba ) transaminase ( 1 ) . vgb is used as first - line treatment for infantile spasms , especially those secondary to tuberous sclerosis , and as an adjunct therapy for medically resistant localization - related childho...
we studied the prevalence , type and severity of vigabatrin ( vgb)-attributed visual field defects ( vfds ) , and used these data to assess the associated risk factors in pediatric patients . medical records were retrospectively reviewed for 67 pediatric patients who received vgb alone or in combination with other an...
paraneoplastic pemphigus ( pnp ) is an extremely severe autoimmune blistering disease associated with neoplasms ; the disease is most commonly of lymphoproliferative origin and presents a high mortality 1 . follicular dendritic cell ( fdc ) sarcoma is rare and classified either as a conventionaltype or as an inflamma...
key clinical messageparaneoplastic pemphigus ( pnp ) is an autoimmune blistering disease associated with neoplasms . the disease is most commonly of lymphoproliferative origin and presents high mortality . we describe a patient with pnp and myasthenia gravis associated with inflammatory pseudotumorlike follicular d...
the 2-year survival of patients starting rrt has progressively increased for cohorts from 2001 to 2006 , measured either as overall survival for patients starting rrt ( to 82.2% for the cohort starting in 2006 reported in the era - edta registry 2012 report ) , on dialysis ( 79.7% ) or receiving living - related kidney...
the 2012 era - edta registry annual report contains both good news and bad news . on the bright side , the 2-year survival of patients starting renal replacement therapy ( rrt ) for chronic kidney disease ( ckd ) , on dialysis or receiving a living - related kidney transplantation , has progressively increased to 82....
since serum prostate specific antigen ( psa ) was introduced as an early detection marker of prostate cancer ( pca ) in the 1980s , several trials involving novel and more precise biomarkers have failed to provide new markers with definitive clinical relevance and applicability . considering the low sensitivity of ps...
purposeprostate specific antigen is not reliable in diagnosing prostate cancer ( pca ) , making the identification of novel , precise diagnostic biomarkers important . since chemokines are associated with more aggressive disease and poor prognosis in diverse malignancies , we aimed to investigate the diagnostic relevan...
homozygous loss - of - function mutations in the gba1 gene cause gaucher disease ( gd ) , the commonest lysosomal storage disorder . this gene encodes glucocerebrosidase ( gcase ) , a lysosomal enzyme responsible for the hydrolysis of the glycolipid substrate glucosylceramide ( glccer ) to ceramide and glucose . re...
gaucher disease ( gd ) , the commonest lysosomal storage disorder , results from the lack or functional deficiency of glucocerebrosidase ( gcase ) secondary to mutations in the gba1 gene . there is an established association between gba1 mutations and parkinson 's disease ( pd ) , and indeed gba1 mutations are now co...
data were derived from the third national health and nutrition examination survey ( nhanes iii , 19881994 ) , a representative survey of the civilian , noninstitutionalized us population conducted by the national center for health statistics ( nchs ) of the center for disease control and prevention . details of the s...
abstractintroductionperiodontitis may add to the systemic inflammatory burden in individuals with chronic kidney disease ( ckd ) , thereby contributing to an increased mortality rate . this study aimed to determine the association between periodontitis and mortality rate ( allcause and cardiovascular diseaserelated )...
syndrome research reveals detailed insight into different aspects of congenital malformation of several body components . such a wide - spread field of interest requires multidisciplinary teamwork , including clinicians and researchers with different backgrounds . in the last decade a complete overview of craniofac...
the paper consists of three parts . part 1 : definition of syndromes . focus is given to craniofacial syndromes in which abnormal traits in the dentition are associated symptoms . in the last decade , research has concentrated on phenotype , genotype , growth , development , function , and treatment . part 2 : ...
unilateral ventriculomegaly is well - described in children secondary to neoplastic or infectious causes , and also due to congenital atresia , with or without the presence of a membrane . idiopathic occlusion of the foramen of monro in adulthood is exceedingly rare , with only 14 cases previously described . these...
asymmetric ventriculomegly due to idiopathic occlusion of the foramen of monro is rare . such patients present with clinical features of raised intracranial pressure ( icp ) . presentation as chronic headache has not been previously described . in the absence of raised icp , pursuing surgical treatment raises a cli...
although even the complete absence of attached gingiva is compatible with oral health , certain clinical situations require definitive gingival augmentation . an epithelized autogenous masticatory mucosal graft procured from palate is preferred by most of the clinicians to increase the zone of keratinized tissue . ...
the indications to increase the width of keratinized gingiva have not been proven beyond doubt ; however it becomes indispensable in certain clinical situations . inspite of frequently encountered complications , palate is considered most preferred area to harvest the free gingival graft ( fgg ) . this procedure ai...
cysteine - rich peptides are of significant and growing interest due to the increasing use of tetracysteine tags for fluorescence imaging of living cells(1 ) and as tools for bioremediation and phytoremediation of toxic heavy metal contaminants such as cadmium and mercury.(2 ) a library of 205 designed tetracysteine pe...
cysteine - rich peptides are valued as tags for biarsenical fluorophores and as environmentally important reagents for binding toxic heavy metals . due to the inherent difficulties created by cysteine , the power of one - bead one - compound ( oboc ) libraries has never been applied to the discovery of short cysteine...
cell culture and reagents293 t cells were maintained in dulbecco 's modified eagle 's medium supplemented with 10% fetal bovine serum and transfected in 6- or 12-well plates by using the calcium phosphate method leading usually to > 70% transfection efficiency . 0.25 g of htt73 encoding plasmid were trans...
deposition of misfolded proteins with a polyglutamine expansion is a hallmark of huntington disease and other neurodegenerative disorders . impairment of the proteolytic function of the proteasome has been reported to be both a cause and a consequence of polyglutamine accumulation . here we found that the ...
cardioembolic stroke , which is an important subtype of ischemic stroke , involves a large infarct volume and multiple vascular territories . the neurologic deficits are grave and develop abruptly.1,2 because cardioembolic stroke is generally severe and frequently recurs , its long - term mortality is high.3,4 in add...
stroke associated with non - valvular atrial fibrillation ( nvaf ) is one of the most important subtypes of ischemic stroke , and its importance is becoming even more apparent in an aging population . to assess the risk of stroke associated with nvaf , the chads2 and cha2ds2-vasc scores are mainly used . such scores ...
this occurs mostly through the action of dedicated transcription factors ( tfs ) , as in the well - known case of the lac operon ( jacob et al . , 1960 ) . on the other hand , gene expression is continuously adjusted to adapt to varying environmental conditions , leading to quantitative relationships between the mol...
summarycoordination of transcription in bacteria occurs at supra - operonic scales , but the extent , specificity , and mechanisms of such regulation are poorly understood . here , we tackle this problem by profiling the transcriptome of the model organism mycoplasma pneumoniae across 115 growth conditions . we ide...
the face is widely regarded as a symbol of self and a smile as a window into one 's personality . in this , the teeth play important roles in the maintenance of a positive self - image , and loss of teeth may result in significant disabilities that can profoundly disrupt social activities . tooth loss may be trauma...
aim : a survey was set out to evaluate the knowledge of patients about tooth replacement as a whole , and assess their awareness of implant - retained prosthesis as an option of tooth replacement.materials and methods : information on sociodemographic characteristics , knowledge about implant - retained tooth as an opt...
cronkhite - canada syndrome ( ccs ) was first described in 1955 by cronkhite and canada . the main symptoms of ccs are diarrhea , weight loss , abdominal pain , and other gastrointestinal complications , such as protein - losing enteropathy and malnutrition with diffuse polyposis in the digestive tract . ccs is a r...
the etiology of cronkhite - canada syndrome ( ccs ) remains unknown and many cases are refractory to treatment . therefore , new therapies are urgently needed . furthermore , a number of ccs cases with gastrointestinal carcinoma have been reported . our patient had rapid onset of ccs and early development of colo...
we used data from the 2006 brazos valley community health assessment ( bvha ) , which was developed by a collaboration of local and regional academic and community - based organizations in the brazos valley of central texas . participants were recruited from adult community residents who resided in one of six rural a...
backgroundsugar - sweetened beverage ( ssb ) consumption is associated with the increasing prevalence of overweight and obesity in the united states ; however , little is known about how less - healthy eating behaviors influence high levels of ssb consumption among rural adults.objectivewe assessed the frequency of ssb...
thunderclap headache attributed to reversible cerebral vasoconstriction ( tharcv ) is a clinical - radiological entity observed in a number of cases reported since 1978 . the tharcv syndrome may include several of the patients experiencing thunderclap headache [ 28 ] , headache associated with sexual activity [ 2 , 8...
thunderclap headache attributed to reversible cerebral vasoconstriction ( tharcv ) is a syndrome observed in a number of reported cases . in this article we reviewed this new headache entity ( idiopathic form ) using the clinical - radiological findings of 25 reported patients . in this series of patients 72% were wome...
97% of the deaths related to childhood cancer occur in the developing world and with the poor resources and multiple other associated problems the survival rates of most childhood cancers do not approach the figures for the developed world . nephroblastoma or wilms tumour is the most common renal tumour seen in child...
background . nephroblastoma is the commonest renal tumour seen in children . it has a good prognosis in developed countries with survival rates estimated to be between 80% and 90% , while in africa it remains low . method . retrospective study of patients diagnosed with nephroblastoma who are seen at 4 paediatr...
chip - seq , gro - seq , or rna - seq libraries were also generated from imr90 , huvec , mcf7 or lncap cells and sequenced on the illumina hi - seq2000 platform . more information about the experiments and detailed descriptions of hi - c data analysis pipeline , including data filtering , normalization , statistical ...
a large number of cis - regulatory sequences have been annotated in the human genome1,2 , but defining their target genes remains a challenge3 . one strategy is to identify the long - range looping interactions at these elements with the use of chromosome conformation capture ( 3c ) based techniques4 . however , pr...
thromboembolic complications have been described in hiv infected patients with higher incidence seen in patients with active opportunistic infections ( oi ) or malignancy , and in patients with acquired immunodeficiency syndrome ( aids ) . various abnormalities predisposing to hypercoagulable state have been reported...
though thromboembolic complications in hiv infected patients have been described in literature , recurrent thrombosis is very rare . we present a six - year - old hiv infected boy who presented with recurrent thrombosis . he initially had renal artery thrombosis , then middle cerebral artery thrombosis and finally ...
mitochondria are highly dynamic organelles that frequently fuse and divide in disease , aging , and development . in vertebrates , mitofusin-1 and -2 ( mfn1 and mfn2 ) are involved in mitochondrial fusion , whereas drp1 and mitochondrial fission factor ( mff ) control mitochondrial fission . recently , it was re...
dynamin - related protein 1 ( drp1 ) is a member of the dynamin family of large gtpase , which cycles between the cytosol and the mitochondrial outer membrane , and mediates mitochondrial fission . using microarray analysis of gene expression in the livers of wild - type and drp1 knockout mice , we have previously id...
medication overuse headache ( moh ) is a chronic headache disorder due to overuse of analgesic medicines , taken to treat a primary headache , and remitted by drug discontinuation . moh has long been considered as a biobehavioural disorder , in which the biological predisposition to develop a chronic headache inter...
medication overuse headache ( moh ) can be considered a clinical condition at the boundaries between drug addiction and chronic pain disorder . the common 196 g > a single - nucleotide polymorphism of bdnf gene , resulting in a valine 66 to methionine ( val66met ) , is related with behaviour disorders and substance...
accurate functional assessment of lesion severity is crucial for clinical decision making in patients with intermediate coronary stenosis . fractional flow reserve ( ffr ) is determined by the ratio of pressure distal to the lesion ( pd)/pressure proximal to the lesion ( pa ) under maximal hyperemia . the pressure ...
objectiveto analyze the influencing factors of the functional significance determined by fractional flow reserve ( ffr ) in intermediate coronary artery stenosis.methodsthe study enrolled 143 patients with 203 intermediate coronary lesions . pressure - derived ffr of these lesions was gained at maximal hyperemia indu...
type 2 diabetes ( t2d ) is one of the leading causes of mortality worldwide , largely due to vascular complications including myocardial infarction and stroke [ 1 , 2 ] . endothelial function , a key determinant of vascular health , is impaired in the diabetic vasculature primarily due to reduced nitric oxide ( no ) ...
vascular dysfunction is an early feature of diabetic vascular disease , due to increased oxidative stress and reduced nitric oxide ( no ) bioavailability . this can lead to endothelial cell senescence and clinical complications such as stroke . cells can become senescent by shortened telomeres and oxidative stress ...
ribonucleotide reductases ( rnrs ) catalyze the conversion of nucleotides to deoxynucleotides in all organisms providing the monomeric precursors required for dna replication and repair.(1 ) the escherichia coli class ia rnr is composed of two subunits : r1 ( 2 ) and r2 ( 2 ) . each subunit is homodimeric and a 1:1 c...
the escherichia coli ribonucleotide reductase ( rnr ) catalyzes the conversion of nucleoside diphosphates to deoxynucleotides and requires a diferric - tyrosyl radical cofactor for catalysis . rnr is composed of a 1:1 complex of two homodimeric subunits : and . incubation of the e441q- mutant rnr with substrate cdp ...
systemic lupus erythematosus ( sle ) is a chronic autoimmune disease of unknown cause which can affect several parts of the body even central nervous system ( cns ) .. among cns manifestations , cerebrovascular accident ( cva ) is one of the severe complications . previous cohort studies revealed that 3 - 20% of sle ...
background : the aim of the present study was to determine the prevalence and prognosis of cerebrovascular accident ( cva ) and its subtypes among iranian patients with systemic lupus erythematosus ( sle).methods : in a cross - sectional study , medical records of 575 sle patients were reviewed . the patients develop...
illumina hi - seq 2500 data is deposited at the ncbi gene expression omnibus ( geo ) database under geo series and is available at the following link : http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=gse64507 . s2 cells were maintained at 28 c in schneider 's drosophila medium ( invitrogen ) , supplemented with 10...
in eukaryotes , nucleosomes participate in all dna - templated events by regulating access to the underlying dna sequence . however , nucleosome dynamics during a genome response have not been well characterized [ 1 ] , [ 2 ] . we stimulated drosophila s2 cells with heat - killed gram - negative bacteria salmonella...
collapse of the hard and soft - tissues occur following extraction and the severity of the horizontal and vertical loss of tissue may reach up to 60% after 2 years . considerable volume of post extraction ridge loss is encountered in the 1 year of tooth loss . these localized ridge defects are characterized by regi...
the aim of the article is to describe a modification of the roll flap , performed at the implant second surgical stage , allowing the correction of small horizontal defects by enhancing the soft - tissue thickness and improving the buccal soft - tissue profile . the advantages for this modification lies in the fact t...
the majority of the developed countries try to associate economic growth with the provision of certain social services and , in this manner , aim at progressively improving the well - being of citizens . accordingly , a social welfare model was developed to guarantee that everyone had , among other things , access to...
explicit forms of rationing have already been implemented in some countries , and many of these prioritization systems resort to norman daniels accountability for reasonableness methodology . however , a question still remains : is accountability for reasonableness not only legitimate but also fair ? the objec...
platform switching , also known as diameter shifting , is a technique combining an implant with a reduced diameter abutment.12 the concept was introduced in the early 1990s after development of a wide diameter implant that was connected to the standard abutment.2345 since it was introduced , the technique has been eval...
purposethe purpose of this study was to analyze the influence of the platform switching concept on an implant system and peri - implant bone using three - dimensional finite element analysis.materials and methodstwo three - dimensional finite element models for wide platform and platform switching were created . in the...
mitochondria are essential organelles whose replication , development , and physiology depend upon coordinated interactions between gene combinations from both the mitochondrial and the nuclear genomes . when genes from both genomes interact , their differing modes of inheritance , bi - parental versus maternal , can r...
mitochondria are essential organelles whose replication , development , and physiology are dependent upon coordinated gene interactions with both the mitochondrial and the nuclear genomes . the evolution of coadapted ( ca ) nuclear mitochondrial gene combinations would be facilitated if such nuclear genes were locat...
the only naturally fluorescent amino acids are the aromatics , i.e. , tryptophan , tyrosine , and phenylalanine , but in general tryptophan fluorescence dominates tyrosine fluorescence , and both dominate phenylalanine fluorescence . the endogenous fluorescence from tryptophan has been used to study propert...
three - photon excitation fluorescence correlation spectroscopy was used to detect oligomerization equilibria of rat liver phosphofructokinase . the fluorescence intensity produced by the three - photon excitation of tryptophan was collected using the diver microscope . in this home - built upright microsco...
the differential diagnoses of a groin mass include inguinal hernia , round ligament varicosities ( rlv ) , mesothelial cysts , lymphadenopathy , endometriosis , subcutaneous lipoma , cyst of nuck ( persistent embryonic remnants of the process vaginalis with cyst formation ) , vascular aneurysms , soft tissue malignanci...
round ligament varicosities during pregnancy are rare , and can easily be mistaken for an inguinal hernia . on physical examination , round ligament varicosities and groin hernia are difficult to distinguish . the diagnosis of round ligament varicosities can be established on gray - scale and color doppler sonograp...
acute myocardial infarction ( ami ) results from total coronary artery occlusion , usually due to thrombus formation on complicated atherosclerotic plaque . the patients with ami have higher mortality rates , especially during the first 30 days . platelets play an important role in development , destabilization , a...
backgroundplatelet - to - lymphocyte ratio ( plr ) is a new prognostic marker in coronary artery disease . we aimed to evaluate the relationship between plr and in - hospital mortality in patients with st - elevated acute myocardial infarction ( ami).material / methodsthe present study included 636 patients with st -...
popliteal artery stenosis or occlusive disease is a common occurrence in elderly patients , diabetics , smokers and those with cardiovascular disease . it leads to significant morbidity and mortality by reducing or completely blocking blood supply through the popliteal artery and into the lower leg . we describe an...
here , we present a case report of a young male who had been travelling in thailand . the patient sustained a relatively minor trauma to the soft tissue under his left third metatarsal head on a piece of coral reef . he subsequently developed an infected ulcer , which did not heal despite appropriate antibiotic the...
laparoscopic posterior mesh rectopexy ( lpmr ) is a good surgical option for rectal prolapse with low morbidity and mortality . specific complication like mesh erosion into the rectum following lpmr is very rare with only one such case , in which mesh got expelled via rectum , reported in literature till date . we ...
laparoscopic posterior mesh rectopexy ( lpmr ) is now an accepted surgical treatment for complete rectal prolapse . it is associated with complications such as partial mucosal prolapse , fecal impaction , constipation , and rarely recurrence . erosion of the mesh into the rectum after lpmr is very rare . we repor...
its phenotype is predominantly characterized by sensorimotor polyneuropathy and/or infiltrative cardiomyopathy ( cm).1,2 moreover , ttr causes a nongenetic disease with deposition of wild - type ( wt ) ttr amyloid ( attr ) mainly in the heart of elderly males.2 in contrast to the hereditary form , no typical mutation i...
backgroundcausative treatment of patients with wild - type transthyretin amyloid cardiomyopathy ( wtattr - cm ) is lacking . recent reports indicate the potential use of epigallocatechin-3-gallate ( egcg ) , the most abundant catechin in green tea , to inhibit amyloid fibril formation . we sought to investigate cha...
eligible patients were required to have histologically or cytologically proven inoperable stage iiia or iiib nsclc as defined in the tnm classification of malignant tumors ( 6th edition ) , no previous chemotherapy or radiation therapy , a performance status of 01 on the eastern cooperative oncology group scale , adequ...
the purpose of this study is to determine the recommended dose ( rd ) of proton beam therapy ( pbt ) for inoperable stage iii nonsmall cell lung cancer ( nsclc ) . we tested two prescribed doses of pbt : 66 gy ( relative biological effectiveness [ rbe ] ) in 33 fractions and 74 gy ( rbe ) in 37 fractions in arms 1 an...
root canal preparation is performed with the use of endodontic instruments and auxiliary chemical substances , seeking to achieve cleaning , shaping , and disinfection , in order to fill the root canal later . the use of rotary nickel titanium ( niti ) instruments has increased considerably due to their safe use , w...
aim : the aim of this study was to evaluate the cutting efficiency of rotary nickel - titanium ( niti ) instruments k3 , niti tee , profile , and quantec with taper size 04/25.materials and methods : the number of samples was 10 for each group ( n = 10 ) . the cutting efficiency was measured by the mass loss from eac...
duchenne muscular dystrophy ( dmd ) is a recessive x - chromosome - linked disease that affects ~1/36006000 liveborn males . the muscular weakness is progressive , causing loss of ambulation by early adolescence ( between 9 and 12 years of age ) . dmd is caused by mutations in the dmd gene that code for dystrophin ...
aim . our aim was ( 1 ) to determine the frequency of insulin resistance ( ir ) in patients with duchenne / becker muscular dystrophy ( dmd / bmd ) , ( 2 ) to identify deleted exons of dmd gene associated with obesity and ir , and ( 3 ) to explore some likely molecular mechanisms leading to ir . materials and methods...
scleroderma , or systemic sclerosis , is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases a 58-year - old woman was informed of her scleroderma , while receiving oral prosthetic rehabilitation . the psychological load of the disease itself , along with dental ...
introduction : scleroderma , or systemic sclerosis , is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseasescase presentation : a 58-year - old woman was informed of her scleroderma , while receiving oral prosthetic rehabilitation . mouth opening limitation had unfo...
bloodstream infection is a leading cause of morbidity and mortality in neonatal intensive care units . the microbiological diagnosis of sepsis in newborns ( nbs ) is a difficult task , because blood culture ( bc ) , which is currently the gold standard for diagnosing nbs ( 1 ) has the disadvantage of producing an ele...
background : nosocomial sepsis ( ns ) in newborns ( nbs ) is associated with high mortality rates and low microbial recovery rates . to overcome the latter problem , new techniques in molecular biology are being used.objectives:to evaluate the diagnostic efficacy of septifast test for the diagnosis of nosocomial seps...
adenoid cystic carcinoma ( acc ) is a malignant tumor characterized by perineural invasion , slow growth , and insidious destruction of surrounding tissues . it usually arises in the major salivary gland , but also in minor salivary gland occasionally . acc arising in the pterygopalatine fossa is extremely rare , o...
abstractadenoid cystic carcinoma ( acc ) arising in the pterygopalatine fossa was rare , only 3 cases have been reported . in previous literature , few authors reported whether the visual deficit could be resolved following the resection of the tumor.one patient with visual dysfunction induced by acc arising in the pte...
lead poisoning has been recognized as a major public health risk , particularly in developing countries . the release of lead into the environment from automobile emissions , lead - based paint or kitchenware , incineration of waste containing lead additives , and the burning of coal and its subsequent bioaccumulatio...
a 19-year - old woman was referred to the emergency surgery department with severe abdominal pain , icterus , and anemia . the patient s clinical and paraclinical findings in addition to her occupational and social history , convinced us to assay blood lead level ( bll ) , which was 41/5 g / dl . therefore toxicolo...
papillary thyroid carcinoma ( ptc ) is the most common form of thyroid gland carcinoma which accounts for 1% of all human malignant tumors . it was reported that the prognosis of ptc is excellent with a 10-year survival exceeding 90% . however , approximately 2050% of ptc patients were found to have central lymph n...
background . papillary thyroid carcinoma ( ptc ) with central lymph node metastases ( clnms ) is common . the objective of this study was to investigate the incidence and risk factors of lymph node metastasis patients with ptc . patients and methods . between january 2013 and february 2015 , a retrospective study...
fasting during ramadan , the 9th month in the islamic calendar , is not mandatory for patients with diabetes mellitus ( dm ) , but many insist on fasting . glucose - lowering therapies are cornerstone for treating all type 2 dm patients to ensure tight glycemic control to prevent acute complications like hyperosmolar...
hypoglycemia is the most common side effects for most glucose - lowering therapies . it constitutes a serious risk that faces diabetic patients who fast during ramadan ( the 9th month in the islamic calendar ) . new glucose - lowering classes like dipeptidyl peptidase-4 ( dpp-4 ) inhibitors , glucagon - like peptid...