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renal transplantation ( rtx ) is best therapeutic modality for end - stage renal disease ( esrd ) . compared with dialysis
, a transplant leads to a longer life , enhances quality of life , and is cost - effective for the health care system . in india ,
175,000 new patients develop esrd annually , and < 10% are abl... | renal transplantation ( rtx ) is the best therapeutic modality for patient suffering from end - stage renal disease ( esrd ) .
deceased donor organ transplantation ( ddot ) accounts for < 4% of rtx in india .
we report 4 years single centre experience on ddot vis - - vis patient / graft survival , graft function i... |
herbal medicines , with their effective pharmacological functions , low toxicity , and less side effects , have been widely used for thousands of years all over the world , which are becoming more and more popular and promising type of medicines [ 15 ] .
however , the same species of herbal medicines with different g... | as an effective method , the fingerprint technique , which emphasized the whole compositions of samples , has already been used in various fields , especially in identifying and assessing the quality of herbal medicines .
high - performance liquid chromatography ( hplc ) and near - infrared ( nir ) , with their uniqu... |
to address the need for sensitive multiplex assays in diagnostic molecular microbiology , we created a polymerase chain reaction ( pcr ) platform in which microbial gene targets are coded by a library of 64 distinct masscode tags ( qiagen masscode technology , qiagen , hilden , germany ) .
microbial nucleic acids ( r... | naturally emerging and deliberately released pathogens demand new detection strategies to allow early recognition and containment .
we describe a diagnostic system for rapid , sensitive , multiplex discrimination of microbial gene sequences and report its application for detecting 22 respiratory pathogens in clinical... |
nerve sheath myxoma ( neurothekeoma ) is an uncommon benign soft tissue tumor of the peripheral nerves with fairly distinctive histological features .
a recent immunohistochemical pattern enables a differentiation between myxoid neurothekeoma , melanocytic tumors , and nervous system tumors .
we report a rare case ... | neurothekeomas are rare benign neoplasms , typically occurring in young patients with a remarkable predilection for the female population . patients usually present with a small nodule in different anatomical sites , commonly involving the face and the upper limb .
we report a case of a three - year - old boy , who p... |
abnormalities in their normal circulating number either in the form of thrombocytosis or thrombocytopenia are associated with many pathologic conditions .
cytokines that stimulate thrombopoiesis are often elevated in cancer , and as a result , various cancers have been associated with thrombocytosis . in addition thr... | background .
an elevated platelet count is often associated with malignancies , and it has been confirmed as an adverse prognostic factor in various cancers including early stage breast cancer .
we sought to determine if thrombocytosis is also a prognostic factor in metastatic breast cancer .
patients and methods... |
proske and
gandevia described proprioception as collective information from specialized peripheral
neural endings , located at the muscle spindle , golgi tendon , or joints , which are capable of
alerting the central nervous system as to joint position , muscle force , and movement via the
dorsal roots of the s... | [ purpose ] the aim of this study was to determine the reliability of a newly designed
dynamometric device for use in frequent force producing / reproducing tasks on the knee
joint . [ subjects and methods ] in this cross - sectional study ( development &
reliability ) , 30 young healthy males and females ( age 2... |
crohn 's disease ( cd ) is one of the clinical forms of inflammatory bowel disease ( ibd ) resulting from a defective regulation of mucosal immune responses to commensal microbiota in genetically susceptible individuals .
the last years have contemplated substantial progress in the identification of the genes involve... | substantial proportion of crohn 's disease ( cd ) patients shows no response or a limited response to treatment with infliximab ( ifx ) and to identify biomarkers of response would be of great clinical and economic benefit .
the expression profile of five genes ( s100a8-s100a9 , g0s2 , tnfaip6 , and il11 ) reportedly... |
we
employ glass microtube structures fabricated by rolled - up nanotechnology
to infer the influence of scaffold dimensionality and cell confinement
on neural stem cell ( nsc ) migration .
thereby , we observe a pronounced
morphology change that marks a reversible mesenchymal to amoeboid
migration mode tran... | |
the discovery that the majority of body tissues and cells harbor vitamin d receptors and that several possess the enzymatic equipment to convert the primary form in circulation into the active form , has provided new insights into the function of this steroid hormone .
there is great interest in the role that vitamin... | objectivethe aim of the study reported here was to determine the prevalence of vitamin d deficiency among elderly men and its association with sun exposure and skin phototypes.subjects and methodsthis was an analytical cross - sectional study , which involved 284 men aged 60 years or over , randomly recruited from a ba... |
the research was conducted at 4 islands on lake victoria ( kibuogi , ngodhe , takawiri , mfangano ) and 1 shoreline community of mbita district ( ungoye ) in western kenya ( figure ) . in this area , the pfpr210 ( community p. falciparum parasite rate standardized to the 2- to 10-year age group )
although in some are... | we looked for mutations in the plasmodium falciparum k13 propeller gene of an artemisinin - resistant parasite on islands in lake victoria , kenya , where transmission in 20122013 was high .
the 4 new types of nonsynonymous , and 5 of synonymous , mutations we detected among 539 samples analyzed provide clues to unde... |
chronic environmental conditions are a growing concern and a significant burden to the health care system due to the magnitude of the problem ( geertrudis and van den bos 1995 ; weiss and sullivan 2001 ; kipen and fiedler 2002 ; litt et al 2004 ; druss et al 2001 ; bowles 2006 ) and lack of efficient and effective mana... | the nova scotia environmental health centre is a treatment facility for individuals with chronic environmental conditions such as multiple chemical sensitivity , chronic fatigue syndrome , fibromyalgia , chronic respiratory conditions and in some cases chronic pain .
the premise of care is to provide a patient - cent... |
idiopathic giant cell myocarditis is a rapid progressive disease with an enormously high mortality because of pump failure or arrhythmias.1 in many cases , clinical course is acute to fulminant , and time span between clinical presentation and start of treatment should be as short as possible .
the diagnostic tool of... | abstracta healthy woman with acute onset of pulmonary oedema and severely depressed left ventricular function underwent endomyocardial biopsy under the clinical suspicion of fulminant myocarditis . while awaiting the results of biopsy , the situation deteriorated to interagency registry for mechanically assisted circul... |
it is characterized by excessive lateral translation of the patella relative to the femur and induction of pain in full knee extension1,2 ) . in most cases , patellar tracking
is assessed in non - weight - bearing conditions where the patient is placed in the sitting position for clinical examination and in the supin... | purposethis research was conducted to compare supine and standing merchant views , to observe radiographic changes of the patellofemoral joint according to weight - bearing conditions , and to evaluate correlation factors affecting patellofemoral joint indices.materials and methodsforty - four patients without skeletal... |
laser photocoagulation is widely used for treating various retinal diseases , including diabetic retinopathy , branch retinal vein occlusion , and central serous retinopathy .
unfortunately , conventional laser treatments are destructive procedures used to create whole - layer damage to retinal tissue .
such invasi... | purpose / aim of the study .
subthreshold micropulse diode laser photocoagulation is an effective treatment for macular edema .
the molecular mechanisms underlying treatment success are poorly understood .
therefore , we investigated the effects of sublethal laser energy doses on a single layer of densely culture... |
obesity , defined as a body mass index ( bmi ) 30 kg / m , is a chronic disease with major health and economic implications and is recognized as one of the greatest contributors of excessive morbidity and mortality in the 21st century .
approximately 30% of the american population is obese , making it the leading n... | introduction .
few data are available on vitamin a deficiency in the gastric bypass population
.
methods .
we performed a retrospective chart review of gastric bypass patients ( n = 69 , 74% female ) .
the relationship between serum vitamin a concentration and markers of protein metabolism at 6-weeks and 1-y... |
methylene blue dye ( mbd ) has been successfully used worldwide with few complications in patients undergoing breast surgery .
we herein describe 2 different complications in 2 patients : 1 ) skin and parenchymal necrosis when mbd was injected subdermally and 2 ) mycoplasma infection caused by contaminated mbd in bre... | introduction : methylene blue dye has been used worldwide successfully with few complications in breast surgery .
we present two different complications involving methylene blue : 1 ) skin and parenchymal necrosis when dye was injected in a subdermal fashion and 2 ) mycoplasma infection caused by contaminated methyle... |
is a lecturer at the institute of chemical technology and engineering at the pozna university of technology in poland .
her areas of scientific interest include the technique of separation , adsorption , surface , and interfacial tension and surfactants .
is a lecturer in the department of technology and instrument... | surfactants are important ingredients of personal care products and household products .
the main characteristic of these compounds is to decrease the surface tension of solvent and resulting many properties such as contact angle , foam properties etc .
the coexistence of other ingredients in the product may affect... |
as the common benign tumor in male , benign prostatic hyperplasia ( bph ) develops as a age - related phenomenon in almost all men , starting at approximately 40 years of age .
clinically , bph leads to a progressive enlargement of the prostate gland , causing both obstructive and irritative lower urinary tract sympt... | purposethe metabolic syndrome ( ms ) has been accepted as an important cause of benign prostatic hyperplasia ( bph ) in old age . however , there are no studies of the influence of ms on prostate volume in relatively young adults .
we evaluated the relationship between parameters of ms and prostate volume in men unde... |
physical dependency is described as an adaptive state that manifests itself as intense physical disturbance when drug use is suspended .
most people believe that addiction or drug dependency is a male phenomenon and females are less involved in these issues . in the islamic republic of iran ,
although there is no... | introduction . addiction in women can expose them to malnutrition , high blood pressure , cancer , and some other dangerous diseases like hepatitis , aids , or other sexual transmitted diseases .
the aim of this study was to assess illegal sexual relations in three groups of women .
methods .
this is a cross - se... |
it is a common misconception that microorganisms isolated in pure culture from an environment represent the numerically dominant and/or functionally significant species in that environment . in fact , microorganisms isolated using standard cultivation methods are rarely numerically dominant in the communities from whic... | our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - proteobacteria , firmicutes , actinobacteria and bacteroidetes - out of 35 bacterial and 18 archaeal phylum - level lineages .
this bias is beginning ... |
breast cancer is a heterogeneous disease comprising numerous distinct entities with different biological features and clinical behaviors ( reis - filho and pusztai , 2011 , weigelt and reis - filho , 2009 ) .
invasive ductal carcinomas of no special type ( idc - nst ) , the commonest histologic type of breast cancer ... | papillary carcinoma ( pc ) is a rare type of breast cancer , which comprises three histologic subtypes : encapsulated pc ( epc ) , solid pc ( spc ) and invasive pc ( ipc ) .
microarray - based gene expression and affymetrix snp 6.0 gene copy number profiling , and rna - sequencing revealed that pcs are luminal breast... |
residual provisional cements and debris on prepared abutment teeth may negatively influence the performance of the definitive luting agent.1 apart from the choice of restorative materials , clinical outcome may be influenced by factors such as tooth preparation , preparation coarseness , type of luting agent , fit of r... | purposeto evaluate the shear bond strength of resin luting agent to dentin surfaces cleansed with different agents like pumice , ultrasonic scaler with chlorhexidine gluconate , edta and the influence of these cleansing methods on wetting properties of the dentin by axisymmetric drop shape analysis - contact diameter t... |
a 42-year - old male patient visited the oral medicine and radiology unit of nhdc , mumbai in 2009 .
he was referred by his family dentist , complaining pain in the left mandibular angle region .
he had difficulty in chewing on the left side and the mouth opening was normal . on the examination ,
the left mandibu... | hyperdontia or supernumerary teeth without associated syndrome is a rare phenomenon , as supernumerary teeth are usually associated with cleft lip and palate or other syndromes such as gardner 's syndrome , cleidocranial dysplasia , and so on .
five patients with supernumerary teeth visited our department .
they ha... |
infantile hemangioma ( ih ) is the most common benign tumor of infancy,1 affecting nearly 10% of children under 1 year old and 30% of premature babies .
prematurity , older maternal age , preeclampsia , and multiple gestations have been suggested to be risk factors of the development of ih.2 approximately 60% of hema... | objectiveto evaluate the efficacy and adverse effects of interferon-2a in the treatment of alarming infantile hemangiomas in the head and neck region.patients and methodsfrom january 2009december 2010 , a subcutaneous injection of interferon-2a was applied to eleven infants with giant multifocal or segmental hemangioma... |
age - related changes in human salivary glands have been described by some studies in humans
and animals
.
the literature regarding aging alterations in human sublingual glands is limited by the number of reports , and some phenomena are still unclear . despite the different methodologies used in... | there are several age - related microscopic changes in the salivary glands , including the increase in the number of duct - like structures ( dls )
. however , the true origin and the phenotype of the dls are not known .
objective to evaluate the phenotype and the cell proliferation index of the dls of human sublin... |
rna recombination is one of the major factors responsible for the generation of new rna viruses and retroviruses
. the biological mechanisms of recombination differ across organisms , but in broad terms recombination results in the creation of mosaic sequences where the evolutionary history at each site may be differ... | a detailed study of putative recombination events and their evolution frequency in the whole genome of the currently known members of the family tombusviridae , comprising 79 accessions retrieved from the international databases , was carried out by using the recco and rdp version 3.31 algorithms .
the first program ... |
one of the fundamental building blocks necessary for the development of nanotechnology are semiconductor nanodots ( nds ) , nanocrystals ( ncs ) or nanoparticles ( nps ) viz .
these are completely quantised , zero dimensional ( 0d ) semiconductors with discrete energy levels whose electronic and optoelectronic proper... | indium oxide ( in2o3 ) nanocrystals ( ncs ) have been obtained via atmospheric pressure , chemical vapour deposition ( apcvd ) on si(111 ) via the direct oxidation of in with ar:10% o2at 1000 c but also at temperatures as low as 500 c by the sublimation of ammonium chloride ( nh4cl ) which is incorporated into the in u... |
upper - limb pain and dysfunction are frequent complaints associated with manual wheelchair
propulsion , which is physically demanding and involves repetitive movements1 .
about 73% of wheelchair users suffer from
chronic upper - limb pain , which is primarily attributed to two factors : wheelchair propulsion
a... | [ purpose ] this study investigated the optimal thickness of the wheelchair backrest for
lumbar load and increased comfort .
[ subjects ] fifteen healthy people participated .
[ methods ] the study examined three randomized backrest conditions : no pad ; a 3-cm - thick
lumbar pad ; and a 6-cm - thick lumbar pad... |
the successful development of novel first - in - class therapeutic agents in the cns has been lagging with respect to other disease areas .
moreover , only 8% of cns drugs that enter phase 1 are approved , with about 65% of the failures due to lack of efficacy or sufficient differentiation in phase iii .
this high ... | we discuss whether a new paradigm , quantitative systems pharmacology ( qsp ) , based on computational neuroscience modeling combined with proper drug target engagement and pharmacology , human pathology , imaging studies , and calibration and validation using clinical studies in human subjects might improve the succes... |
the oec tissue samples were obtained during surgical operations performed at pusan national university hospital , korea , from 1999 to 2008 . a total of 123 patients ( mean age , 49.5 years ; range , 15 to 82 years ) who underwent surgical resection for oec were examined .
pathological data , such as pathologic stage... | backgroundepithelial - mesenchymal transition ( emt ) is associated with tumor hypoxia .
emt is regulated , in part , by the action of twist , which inhibits of e - cadherin expression and may interfere with the p53 tumor - suppressor pathway.methodswe examined the expression of twist , e - cadherin , hypoxia - induc... |
fluoride is an ubiquitous element in the environment and has a remarkable prophylactic effect at low concentrations by inhibiting dental caries , while at higher concentrations it causes dental and skeletal fluorosis .
endemic fluorosis is prevalent in many parts of the world and causes damage not only to hard tissue... | the generation of ros and lipid peroxidation has been considered to play an important role in the pathogenesis of chronic fluoride toxicity . in the present study
, we observed that fluoride activated bv-2 microglia cell line by observing ox-42 expression in immunocytochemistry .
intracellular superoxide dismutase ... |
malaria is caused by one or a combination of four species of plasmodia and leads to over one million deaths , of which over 75% occur in african children under 5 years infected mainly with plasmodium falciparum ( pf ) .
pf and plasmodium vivax ( pv ) are identified as the plasmodium species responsible for causing th... | introduction . the estimation of malaria parasite density using a microscope heavily relies on white blood cells ( wbcs ) counts
. an assumed wbcs count of 8000/l has been accepted as reasonably accurate in estimating malaria parasite densities due to the challenge to accurately determine wbcs count . method .
the ... |
anatomical cadaver studies have shown that vastus medialis oblique ( vmo ) fibers originate
from the distal part of the adductor magnus .
thus , vmo fibers provide stability during the
contraction that occurs in hip adduction1 .
hip adduction also stretches the vmo fibers , adjusting the length and tension prop... | [ purpose ] the purpose of this study was to provide data for decision making regarding
the optimal and maximal hip adduction loads for clinical and fitness purposes ,
respectively .
[ subjects ] forty - eight ( 24 males , 24 females ) asymptomatic adults
participated in this study . [ methods ]
subjects perf... |
the technology
opens new exciting research and technological possibilities in dissipative
systems out of equilibrium .
a plethora of applications , such as lab - on - a - chip
analysis , diagnostics , and particle synthesis , can be accessed , to
mention a few examples .
one particularly important highlight... | in this work we investigate the interplay
between flow and boundary
condition effects on the orientation field of a thermotropic nematic
liquid crystal under flow and confinement in a microfluidic device .
two types of experiments were performed using synchrotron small - angle
x - ray - scattering ( saxs ) . ... |
postoperative pain is a critical concern affecting the choice between open and endoscopic surgical techniques and it is the main outcome parameter in both techniques .
thus , postoperative pain is frequently assessed in studies comparing the results of open and endoscopic release in carpal tunnel syndrome ( cts ) , a... | background : results of open and endoscopic carpal tunnel surgery were compared with many studies done previously . to the best of our knowledge ,
difference in pain after endoscopic carpal tunnel release ( ectr ) and open carpal tunnel release ( octr ) has not been objectively documented in literature .
the aim of... |
the activation of membrane receptors by hormones and growth factors results in the localized generation of intracellular second messengers .
the hydrolysis of membrane phospholipids and the generation of biologically active products play important roles in the regulation of cell function and cell fate .
well known ... | hydrolysis of phosphatidylcholine by phospholipase d ( pld ) leads to the generation of the versatile lipid second messenger , phosphatidic acid ( pa ) , which is involved in fundamental cellular processes , including membrane trafficking , actin cytoskeleton remodeling , cell proliferation and cell survival .
pld ac... |
one possible option for radical prostate cancer treatment is the highly efficacious radical prostatectomy ( rp ) .
however , treatment failures still occur in a significant percentage of patients [ 1 , 2 ] .
therefore , methods to improve the treatment results continue to be sought ; one of these methods is adjuvan... | this article is an attempt to present a contemporary view on the role of the kinetics of psa levels as defined by psa doubling time ( psadt ) and psa velocity ( psav ) in the decision - making process to initiate salvage radiotherapy in patients with prostate cancer after radical prostatectomy ( rp).the dynamics of the... |
in sweden , approximately 400 patients per year are newly diagnosed with cancer of the esophagus and an additional 200 with cancer of the cardia .
there are several methods to determine this diagnosis : computed tomography ( ct ) , endoscopic examination of the esophagus ( esophagoscopy ) combined with endoscopic ult... | background . while the surface of a cell normally has some amount of somatostatin receptors , these receptors are overexpressed to a very high degree in multiple neoplastic diseases .
no data exist for esophageal carcinoma .
purpose . to find out whether esophageal carcinoma could be imaged using somatostatin recep... |
neurodegenerative diseases represent a large group of neurological disorders with heterogeneous clinical and pathological expressions , affecting specific groups of neurons , in specialized functional anatomic systems .
a mixture of environmental and genetic factors seems to engender neurodegenerative diseases , and ... | in few years our understanding of microrna ( mirna ) biogenesis , molecular mechanisms by which mirnas regulate gene expression , and the functional roles of mirnas has been expanded .
interestingly , numerous mirnas are expressed in a spatially and temporally controlled manner in the nervous system , suggesting that... |
approximately 20 million people in the united states are infected with genital human papillomavirus ( hpv ) .
an estimated 5.5 million people will acquire a new genital hpv infection each year , and the incidence of infection is highest among sexually active adolescent girls and young women between the age of 18 and ... | background . hpv vaccination may prevent thousands of cases of cervical cancer . we aimed to evaluate the understanding and acceptance of the hpv vaccine among adolescents
. methods .
a questionnaire was distributed to adolescents at health clinics affiliated with a large urban hospital system to determine knowledg... |
low back pain ( lbp ) is thought to have originated from intervertebral lesion ( 739% ) .
most patients with discogenic lbp respond well to conservative care , but 5% of patients suffer from constant pain313 ) .
various treatment modalities , such as injection therapy , fusion surgery , total disc replacement , and... | objectivelow back pain , caused intervertebral disc degeneration has been treated by thermal annuloplasty procedure , which is a non - surgical treatement .
the theoretical backgrounds of the annuloplasty are thermal destruct of nociceptor and denaturization of collagen fiber to induce contraction , to shrink annulus... |
facial angiofibromas seen in tuberous sclerosis are usually bilateral.unilateral facial angiofibromas are seen rarely .
unilateral facial angiofibromas , however , represent a rare variant of tsc , as only few cases are reported in the literature .
we describe a case of a 30-year - old male who presented with unila... | tuberous sclerosis ( tsc ) is an autosomal dominant hereditary condition with many varied forms of clinical presentation .
the most frequent cutaneous findings in tsc include multiple angiofibromas , hypopigmented macules , periungual fibromas , and shagreen patch . rarely , unilateral multiple facial angiofibromas h... |
anaphylaxis is a rapid , potentially fatal , multiorgan system , allergic reaction caused by the excessive release of mediators including histamine and cytokines / chemokines from mast cells and basophils upon allergen / ige stimulation .
it typically causes a number of symptoms including an itchy rash , throat swell... | anaphylaxis is a severe systemic allergic reaction which is rapid in onset and potentially fatal , caused by excessive release of mediators including histamine and cytokines / chemokines from mast cells and basophils upon allergen / ige stimulation .
increased prevalence of anaphylaxis in industrialized countries req... |
today , cancer is one of the important , fundamental problems in health and treatment worldwide , and its importance is increasing in countries . colorectal cancer ( crc ) is the most prevalent gastrointestinal cancer and the cause of 10% of the cancer mortalities . in iran
in addition , lifestyle is an important ris... | background : type 2 diabetes mellitus ( dm ) and hypertension are worldwide epidemic .
association between dm and colon cancer was obtained in previous studies .
prevalence of dm and hypertension in the patients with colorectal cancer ( crc ) has not been reported in iran .
the present study was aimed to investig... |
twenty - four different integrins are expressed in humans , each composed of non - covalently associated and chains ( hynes , 2002 ) .
integrins have large extracellular domains , single - pass transmembrane segments , and short intracellular tails . lacking enzymatic activity ,
the short integrin cytoplasmic dom... | lymphocyte function - associated antigen-1 ( lfa-1 ) is a heterodimeric integrin consisting of l ( gene name , itgal ) and 2 ( gene name , itgb2 ) subunits expressed in all leukocytes .
lfa-1 is essential for neutrophil recruitment to inflamed tissue .
activation of lfa-1 by chemokines allows neutrophils and other ... |
airway acidification has been shown to be attained by either the exogenous way , that is , the microaspiration of acid contents into the airway during gastroesophageal reflux and inhalation of low ph pollutant aerosol , or the endogenous way , that is , ischemia and inflammation of the airways in inflammatory diseases ... | an acidic microenvironment has been shown to evoke a variety of airway responses , including cough , bronchoconstriction , airway hyperresponsiveness ( ahr ) , infiltration of inflammatory cells in the lung , and stimulation of mucus hyperproduction . except for the participation of transient receptor potential vanillo... |
healthcare expenditure is substantial since syncope is a common symptom with a variety of potential underlying causes leading to patient visits to physicians , the emergency department , and to hospitalizations after syncope with or without associated trauma .
syncope was the fifth most common cause for an emergency ... | aimsthe observational picture ( place of reveal in the care pathway and treatment of patients with unexplained recurrent syncope ) registry enrolled 570 patients with unexplained syncope , documented their care pathway and the various tests they underwent before the insertion of an implantable loop recorder ( ilr ) .
... |
the competition for solar photons among
aquatic photosynthetic
organisms striving to maintain viability at various depths in the
water column is fierce , often requiring adaptation of the species
for survival .
a prime example of the development of adaptive traits
is found in the purple photosynthetic bacte... | rhodopin , rhodopinal , and their glucoside
derivatives are carotenoids
that accumulate in different amounts in the photosynthetic bacterium , rhodoblastus ( rbl . ) acidophilus strain 7050 , depending on the intensity of the light under which
the organism is grown .
the different growth conditions also have a ... |
multiple sclerosis ( ms ) is a chronic inflammatory demyelinating disease of the central nervous system , characterized by various levels of physical , emotional , cognitive , and social difficulties .
thirty to fifty - five percent of ms patients consider fatigue as the most disabling symptom .
fatigue can occur i... | background and purpose . fatigue and memory impairment are common symptoms in multiple sclerosis ( ms ) and both may interact with cognition . this can contribute to making a complaint misrepresentative of the objective disorder .
we sought to determine whether fatigue complaint in ms reflects memory impairment and i... |
placental abruption occurs when the placenta partially or completely detaches from the uterine wall during the pregnancy or during parturition before the delivery of the fetus ; it occurs in 0.5 - 1.5% of all pregnancies .
clinical presentation varies depending on the degree of placental detachment . however , blood ... | a 40-year old woman , gravida 4 , para 4 , presented with sudden lower abdominal pain and severe vaginal bleeding at 17 weeks of gestation . clinical symptoms and ultrasonographic finding revealed placental abruption .
the volume of bleeding was heavy and led to disseminated intravascular coagulation and hypovolemic ... |
the majority of women with human immunodeficiency virus 1 ( hiv ) are of reproductive age and may use an efavirenz- ( efv- ) containing antiretroviral ( arv ) regimen [ 1 , 2 ] .
efv is a nonnucleoside reverse transcriptase inhibitor ( nnrti ) indicated in combination with other antiretroviral agents for the treatmen... | objectives . compare the plan b levonorgestrel ( lng ) area under the concentration- time curve ( auc12 ) prior to and with efavirenz ( efv ) . design .
prospective , open - label , single - arm , equivalence study . methods .
healthy hiv - negative subjects underwent 12 hr intensive pharmacokinetic ( pk ) samplin... |
artemisinin , derived from sweet wormwood , artemisia annua , is the spearhead of anti - malarial chemotherapy . in 2004 ,
the world health organization ( who ) recommendation that artemisinin - based combination therapy ( act ) should be the norm for the treatment of falciparum malaria in most endemic countries came... | artemisinins are the most important anti - malarial drugs in use today , but are more costly than previous anti - malarials and production and price tend to fluctuate .
alternative ways of producing artemisinins are discussed here in the light of a recent paper in bmc biotechnology on improving the yield of the precu... |
the battle with diseases started since the advent of man on earth and it will continue in an endless warfare .
the discovery of antibiotics in the 1950s has turned the result of this war in favor of man , but few years later microbes returned with mutant strains , resistant to almost all inventive antibiotics .
stu... | background : hibiscus sabdariffa l. is a plant native to tropical africa and intensively cultivated in sudan . its calyces are widely consumed with many uses in sudanese folk medicine.materials and methods : the dried calyces of h. sabdariffa were subjected to soak in 80% v / v methanol to get the methanolic extract , ... |
laparoscopic cholecystectomy is one of the most commonly practiced surgeries for gall bladder diseases in the present era . due to its well - known advantages like less post - operative pain , shorter hospitalization and faster functional recovery , laparoscopic cholecystectomy is also termed as patient friendly surger... | background and aim : dexmedetomidine is a 2 agonist with sedative , sympatholytic and analgesic properties and hence , it can be a very useful adjuvant in anaesthesia as stress response buster , sedative and analgesic .
we aimed primarily to evaluate the effects of low dose dexmedetomidine infusion on haemodynamic re... |
a 58-year - old man was admitted to our opthalmology department with the complaint of decreased visual acuity .
best - corrected visual acuity ( bcva ) was 0.2 on snellen 's acuity chart in the right eye , 1.0 in the left eye and bilateral intraocular pressure meaurements were in normal limits .
fundus fluorescein ... | a 58-year - old man admitted to our opthalmology department with the complaint of branch retinal vein occlusion .
he was treated with intravitreal ozurdex in the right eye .
two days after the injection , the patient presented with ocular pain and the visual acuity was hand movement .
a diagnosis of endophthalmit... |
retained foreign body granulomas in the intervertebral disc space due to penetrant traumas are very rare like other paraspinal ones2,3,57,10 ) . to our knowledge ,
all of the reported retained foreign bodies in the intervertebral disc space were from missile injuries and there was not any report involving a retained ... | we report a patient with a wooden foreign body granuloma in the intervertebral disc space being symptomatic 17 years after a paraspinal penetrant trauma . according to the our result of the search for wooden foreign body granulomas ,
this is the first case suffered from a wooden foreign body granuloma in the interver... |
due to the increased incidence of cancer , the production and use of antitumor drugs is on the rise . majority of antitumor drugs , cytotoxic , which may cause cancer , mutations , and other effects .
several studies revealed side - effects of these drugs on health workers , for instance , the increasing chance of ch... | context : the use of antineoplastic agents for the treatment of cancer is an increasingly common practice in hospitals . as a result , workers involved with handling antineoplastic drugs may be accidentally exposed to these agents , placing them at potential risk for long - term adverse effects .
this study aimed to ... |
this randomized , double blind , placebo - controlled , 2-period , 2-treatment crossover trial evaluated the safety and efficacy of 21 days of twice daily ( bid ) treatment with tv-45070 ointment in phn patients .
the study was conducted between august , 2010 and march , 2011 at 24 sites in the united states .
the ... | objective : the objective was to evaluate the safety and efficacy of tv-45070 ointment , as a treatment for postherpetic neuralgia , and to explore the response in patients with the nav1.7 r1150w gain - of - function polymorphism.materials and methods : this was a randomized , placebo - controlled , 2-period , 2-treatm... |
pyrexia ( fever ) is an important clinical sign / symptom that occurs either as an isolated event or as part of a constellation of signs and symptoms of some hazards of blood transfusion .
transfusion pyrexia ( tp ) is the elevation of temperature 1c from baseline or temperature > 38c , with or without chills or rigo... | background / purpose . transfusion pyrexia ( fever ) is an important clinical sign / symptom occurring either as an isolated event or as part of a constellation of signs and symptoms in relation to blood transfusion .
it is an important cause of morbidity and may be an important sign of life - threatening complicatio... |
thyroid - stimulating hormone ( also known as thyrotropin , tsh ) stimulates the thyroid gland to produce thyroxine ( t4 ) and triiodothyronine ( t3 ) , which is a metabolism - stimulating hormone .
tsh is synthesized and secreted by thyrotrope cells in the anterior pituitary gland and regulates the endocrine functio... | the aim of this study is to investigate differences in thyroid - stimulating hormone ( tsh ) level in patients with acute schizophrenia , unipolar depression , bipolar depression and bipolar mania .
serum level of tsh was measured in 1,685 caucasian patients ( 1,064 women , 63.1 % ; mean age 46.4 ) .
mean serum ts... |
trauma history refers to an individual 's total range of experiences of possibly distressing events during a defined period of time , either a lifetime or a shorter period . in accordance with the diagnostic and statistical manual of mental disorders , 4th edition ( dsm - iv ) ptsd a1a2 criteria ( american psychiatric ... | backgroundnews journalists are an occupational group with a unique task at the scene of an unfolding crisis to collect information and inform the public about the event . by being on location , journalists put themselves at risk for being exposed to the potentially traumatic event.objectiveto compare potentially traum... |
uterine artery anatomic variants have been the subject of detailed study , since the beginning of last century , given fibromyoma role in the pathogenesis of arterial vasculature .
according to various studies , there are certain classifications of uterine artery anatomical variants and paper proposes such a classifi... | uterine artery embolization as a therapeutic method in fibromyoma requires a good knowledge of the origin of the uterine artery to the success of this procedure involving selective catheterization .
this study presents a classification of anatomical variants of uterine artery as a retrospective review of consecutive ... |
the
major reactive aldehyde produced during peroxidation of polyunsaturated
fatty acids , malondialdehyde ( mda ) , reacts with nucleophilic sites
of dna and protein to form oxopropenyl adducts .
reaction of mda with
dna produces primarily 3-(2-deoxy--d - erythro - pentofuranosyl)pyrimido[1,2-]purine-10(3h)-o... | base propenals are products of the
reaction of dna with oxidants
such as peroxynitrite and bleomycin .
the most reactive base propenal ,
adenine propenal , is mutagenic in escherichia coli and reacts with dna to form covalent adducts ; however , the reaction
of adenine propenal with protein has not yet been i... |
cyclic episodes result in the momentary closure , partial or complete , of the upper airway at the level of the pharynx .
the repeated pauses in breathing can lead to intermittent hypoxia ( ih ) and increased reactive oxygen species ( ros ) .
the increase of ros in osa is likely due to the repeated oxygen depletion... | sleep apnea is a breathing disorder that results from momentary and cyclic collapse of the upper airway , leading to intermittent hypoxia ( ih ) .
ih can lead to the formation of free radicals that increase oxidative stress , and this mechanism may explain the association between central sleep apnea and nonalcoholic ... |
spermatocytic seminoma ( ss ) is an uncommon testicular germ cell neoplasm with distinct histopathological features .
it usually occurs in older men with mean age of 53.6 years ( range 19 - 72 years ) .
it bears an excellent prognosis but tends to behave aggressively and renders a poor prognosis if associated with ... | the sarcomatous differentiation occurring in spermatocytic seminoma ( ss ) renders an aggressive behavior with metastatic potential to this relatively indolent neoplasm .
correct identification of this sarcomatous component is essential as further management differs .
herein , we report a case of young male with ss... |
in the previous issue of critical care , joulin and colleagues describe an animal model of lipopolysaccharide ( lps)-induced impaired myocardial systolic and diastolic function .
diastole is composed of two physiological phenomena : myocardial stiffness , which is energy independent , and active relaxation , which ... | sepsis - induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function .
one of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize , visualize , and measure . with the advent of preload - independent measurements fo... |
hepatitis a virus ( hav ) infection is considered as an important public health concern .
it is estimated that about 1.4 million cases of hav infection occur every year worldwide ( 1 , 2 ) .
healthcare workers ( hcws ) can always be exposed to hav infected patients and if they were non - immune , they will also be ... | context : hepatitis a virus ( hav ) infection is an important public health problem . it is estimated that about 1.4 million cases of hav infection occur every year worldwide .
non - immune healthcare workers ( hcws ) can be at higher risk of hav infection in comparison to general population and an appropriate preven... |
dna - based therapeutics may become a new generation of drugs for the treatment of brain disorders provided that the problem of its delivery across the blood - brain barrier ( bbb ) and into brain cells is solved .
a global distribution of the transgene throughout the brain is needed for most of the enzyme replacemen... | the application of blood - borne gene therapy protocols to the brain is limited by the presence of the blood - brain barrier ( bbb ) .
viruses have been extensively used as gene delivery systems . however , their efficacy in brain is limited by the lack of transport across the bbb following intravenous ( iv ) adminis... |
adjuvant radiotherapy ( rt ) after conservative surgery for early stage breast cancer is a standard of care that is well tolerated by the patients in terms of compliance and risk of adverse effects . in most cases ,
breast cancer patients have a long life expectancy with a risk of late normal tissue complications tha... | purposethis study was conducted to investigate the role of four polymorphic variants of dna methyltransferase genes as risk factors for radiation - induced fibrosis in breast cancer patients .
we also assessed their ability to improve prediction accuracy when combined with mitochondrial haplogroup h , which we previo... |
g protein - coupled receptors ( gpcrs ) are regarded to take up more than one - fourth of marketed human medicines [ 1 , 2 ] .
drugs targeting gpcrs account for the majority of the best - selling drugs and about 40% of all prescription pharmaceuticals in the marketplace .
histamine receptors belong to one family of... | to learn the differences between the structure - activity relationship and molecular vibration - activity relationship in the ligand - receptor interaction of the histamine receptor , 47 ligands of the histamine receptor were analyzed by structural similarity and molecular vibrational frequency patterns .
the radial ... |
neurologic complications from mycoplasma pneumoniae have been known since the 1940s.1 encephalitis is the most common complication , and occurs most often in children .
a review by lerer and kalavsky2 found that 53% of patients with central nervous system ( cns ) disease associated with m. pneumoniae were between the... | we report a rare cause of encephalitis that is not often described in the adult clinical setting . our case was a 16-year - old female who presented with a clinical picture of viral encephalitis ; however , magnetic resonance imaging showed a demyelinating lesion of the left frontal lobe . in this age group ,
differe... |
the term " temporomandibular disorders " ( tmd ) refers to clinical alterations characterized by signs and symptoms involving the masticatory muscles or the temporomandibular joint ( tmj ) or both30 .
tmd have been studied since the beginning of the last century and became worldwide known when costen4 published an ar... | objective : the aims of this study were to compare the prevalence of temporomandibular disorders ( tmd ) in individuals submitted to either orthodontic or ortho - surgical class iii malocclusion treatment and to assess the influence of occlusal aspects on tmd severity.material and methods : the sample consisted of 50 i... |
bridging conduits ( bc ) also termed thick tunneling nanotubes ( tnt ) are cellular processes that sustain long distance intercellular transport of rna , organelles , and receptors . in immunocytes , they enable antigen presentation and pro - inflammatory immune responses.(5 ) supported by both actin filament and micro... | bridging conduits ( bc ) are tubular protrusions that facilitate cytoplasm and membrane exchanges between tethered cells .
we now report that the human immunodeficiency virus type i ( hiv-1 ) exploits these conduits to accelerate its spread and to shield it from immune surveillance .
endosome transport through bc d... |
in general , endodontically treated teeth are considered to have increased susceptibility to fracture than vital teeth .
the reasons attributed to this are the dehydration and loss of dentin caused during the endodontic therapy along with the pressure applied during obturation of the filling material as in lateral co... | aim : to compare and assess the fracture resistance of endodontically treated teeth with those that have been subjected to endodontic retreatment.materials and methods:30 extracted mandibular premolars were decoronated at cementoenamel junction and randomly divided into 2 groups . in group i endodontic treatment was pe... |
one of the reasons for the changes is concern for the patient 's safety .
to err is human , a landmark report released by the institute of medicine ( iom ) in 1999 estimated that medical errors cause injury to approximately 3% of hospital patients and results in a minimum of 44,000 and perhaps as many as 98,000 deat... | one of the most important steps in curriculum development is the introduction of simulation- based medical teaching and learning .
simulation is a generic term that refers to an artificial representation of a real world process to achieve educational goals through experiential learning .
simulation based medical ed... |
autologous bone grafts remain the gold standard for the treatment of congenital craniofacial bone disorders , such as alveolar cleft [ 18 ]
. however , autologous bone grafts have potential problems , which include donor site morbidity and limitations to the amount of bone that can be harvested [ 913 ] .
porous bet... | autologous bone grafts remain the gold standard for the treatment of congenital craniofacial disorders ; however , there are potential problems including donor site morbidity and limitations to the amount of bone that can be harvested .
recent studies suggest that granulocyte colony - stimulating factor ( g - csf ) p... |
prostate cancer is a significant cause of death among men in europe and the united states . in the united states ,
the incidence increased to 24.8 per 100,000 men in 2009 , with a two - fold increase over that in 2008 .
however , all available treatments , including prostatectomy , may significantly impact the pati... | purposeto evaluate the validity of the cancer of the prostate risk assessment ( capra ) score , a newly developed nomogram for preoperative prediction of recurrence after radical prostatectomy , in a single institution in korea.materials and methodswe retrospectively studied 115 men who had undergone radical prostatect... |
brca1 and brca2 are tumour - suppressor genes located on chromosomes 17q21 and 13q12 , respectively .
functional brca proteins are involved in the maintenance of genome stability through repair of dna double - strand breaks ( dsbs ) by homologous recombination ( hr ) , cell growth regulation and control of cell divis... | brca1 and brca2 are tumour - suppressor genes encoding proteins that are essential for the repair of dna double - strand breaks by homologous recombination ( hr ) .
cells that lack either brca1 or brca2 repair these lesions by alternative , more error - prone mechanisms .
individuals carrying germline pathogenic mu... |
intraventricular tendons was first observed 115 years ago.1 they are usually thin , fibrous or fibromuscular structures that traverse the left ventricular cavity.2 they may be single or multiple and have no connection to the valvular cusps.2 false tendons can be an isolated finding or can be associated with cardiac abn... | intraventricular tendons are structures that was identified more than a hundred years ago .
it has been suggested that they represent intracavitary radiations of the bundle of his and that they may be an isolated finding or be associated with structural cardiac abnormalities.loukas et al divided these structures into... |
supplementary material is available for this article at 10.1007/s13659 - 011 - 0001 - 0 and is accessible for authorized users .
| 6/7-seco rearranged spiro - indolone alkaloids , meloyunines a ( 1 ) and b ( 2 ) and a monoterpenoid quinoline alkaloid meloyunine c ( 3 ) together with its possible intermediate 14,15-dehydromelohenine b ( 4 ) , and their precursor 14-vincamenine ( 5 ) were isolated from melodinus yunnanensis .
all structures were e... |
multiple myeloma ( mm ) is a clonal b - cell dyscrasia characterized by the accumulation of monotypic paraprotein - secreting cells in the bone marrow ( bm ) , in close contact with adjacent cells in its microenvironment .
a recent study reported that angiogenesis plays a significant role in the pathogenesis of mm . ... | backgroundangiogenesis plays a significant role in complex inflammatory and angiogenic processes and is also involved in multiple myeloma ( mm ) pathogenesis .
il-37 is a proinflammatory cytokine in antitumor activity .
our purpose was to evaluate the il-37 clinical significance on mm.material/methodswe measured se... |
the vast majority of women in prison have experienced some sort of interpersonal or sexual violence in their lives , with estimates as high as 90% ( commonwealth of ma , 2005 ; women in prison project , 2006 ) . yet , ironically , women , especially those who were homeless , drug addicted or living with dangerous partn... | backgroundrates of posttraumatic stress disorder and exposure to violence among incarcerated males and females in the us are exponentially higher than rates among the general population ; yet , abrupt detoxification from substances , the pervasive authoritative presence and sensory and environmental trauma triggers can... |
tho tho cattle ( bos indicus ) is a local indigenous bovine species of north eastern hilly ( neh ) region especially in nagaland state of india .
the bull is half of the herd in animal husbandry , which indicates that the sire is one of the parents of all the calves in the herd .
since the bull has more genetic inf... | the present study was undertaken to assess the relationship between the scrotal circumference and testicular parameters with body weight and age in tho tho bulls ( bos indicus ) , which were maintained at around the villages of national research centre on mithun ( icar ) , jharnapani , nagaland , india .
a total of 3... |
leptin , an adipocyte derived cytokine , primarily was known to be involved in the regulation of food intake and energy expenditure ( dardeno et al . , 2010 ) .
later on studies showed the role of leptin in the immune system modulation ( lord et al . , 1998 ) .
the studies describing the role of leptin in diabetes ... | in vitro and in vivo studies have shown conflicting results regarding heat shock protein ( hsp ) and leptin correlation .
more importantly both hsp70 and leptin are correlated with c reactive proteins .
the purpose of the present study was to study the correlation between serum hsp70 and leptin levels in patients w... |
p73 is a member of the p53 family , although p73 ( and p63 ) are more closely related to the ancestral form of the protein than p53 .
these three mammalian genes encode transcription factors that play key roles as regulators of proliferation , differentiation , cell death , stem cell renewal , and cell fate commitmen... | p73 , a transcription factor of the p53 family , plays a key role in many biological processes including neuronal development .
indeed , mice deficient for both tap73 and np73 isoforms display neuronal pathologies , including hydrocephalus and hippocampal dysgenesis , with defects in the ca1-ca3 pyramidal cell layers... |
rna - guided machineries
provide highly selective and rationally
programmable tools for the site - specific manipulation of nucleic acids .
several endogenous riboproteins are known that are steered toward
their endogenous targets by nucleic acid hybridization and that are
readily re - addressed toward new ta... | site - directed
rna editing allows for the manipulation of rna and
protein function by reprogramming genetic information at the rna level .
for this we assemble artificial rna - guided editases and demonstrate
their transcript repair activity in cells and in developing embryos
of the annelid platynereis dumer... |
in the human gut , trillions of bacteria interact with the host 's systemic immune system in a complex balance between immune activation and tolerance .
pathogen recognition receptors ( prrs ) have been shown to play an important role in the differentiation between commensal and pathogenic bacteria .
the detection ... | the activation of specific cytosolic pathogen recognition receptors , the nucleotide - binding - oligomerization - domain- ( nod- ) like receptors ( nlrs ) , leads to the assembly of the inflammasome , a multimeric complex platform that activates caspase-1 .
the caspase-1 pathway leads to the upregulation of importan... |
telomeres , unique structures at the physical ends of linear eukaryotic chromosomes , were first described almost 70 yearsago by hermann muller in his classic studies of the fruit fly drosophilia melanogaster ( 1 ) .
he noted that chromosomal inversions resulting from ionizing radiation ( ir)-induced double - strand ... | telomeres are composed of repetitive g - rich sequence and an abundance of associated proteins that together form a dynamic cap that protects chromosome ends and allows them to be distinguished from deleterious dsbs .
telomere - associated proteins also function to regulate telomerase , the ribonucleoprtotein respons... |
extensive epidemiological investigations have indicated that the incidence of type 1 diabetes mellitus ( t1 dm ) in children and adolescents is increasing steadily year by year and is presumably to be doubled by 2020 [ 15 ] . however , the etiology and pathogenesis of t1 dm are complex and have not been fully elucidate... | type 1 diabetes mellitus ( t1 dm ) is an organ - specific autoimmune disease characterized by chronic and progressive apoptotic destruction of pancreatic beta cells . during the initial phases of t1 dm
, cytokines and other inflammatory mediators released by immune cells progressively infiltrate islet cells , induce ... |
nurses must be aware of and consider implementing novel strategies to ensure that all community members healthcare needs , which are a basic human right , are addressed .
clear data are available on refugees and migrants who take formal routes to gain asylum and residency .
more than 625,000 asylum applications wer... | abstractpurposeto describe a novel strategy using linking social capital to provide healthcare access to irregular migrants with low literacy , low numeracy , and limited cultural assimilation in a european metropolitan area.organizing constructpublic data show numerous shortcomings in meeting the healthcare needs of r... |
toxic epidermal necrolysis ( ten ) is a rare , life - threatening medical emergency in which there is extensive epidermal sloughing and mucositis .
it is caused by a variety of different drugs ( most commonly sulfonamides , non - steroidal anti - inflammatory drugs , anti - malarials , anticonvulsants and allopurinol... | toxic epidermal necrolysis ( ten ) is a rare , but life - threatening medical emergency with significant morbidity and mortality .
current treatment standards for ten patients include stopping all possible drugs associated with the new onset of symptoms , prompt referral and treatment in a specialized center with flu... |
postpartum depression ( ppd ) is considered as an important health problem in modern societies .
the prevalence of pnd ranges from 7.6% to 39% in various areas of the world and differs according to the population tested and screening tools used [ 14 ] .
the diagnostic and statistical manual of mental disorders defi... | there are various factors related to postpartum depression . in this study
we have aimed to determine the effect of mode of delivery on the risk of postpartum depression .
a total of 318 women who applied for delivery were included in the study .
previously diagnosed fetal anomalies , preterm deliveries , stillbi... |
there is no question that obesity is a major health problem for developed countries , and has recently been identified more frequently in children .
it contributes to type 2 diabetes mellitus , arteriosclerosis ( including stroke and coronary artery disease ) , musculoskeletal disorders , and some cancers .
it is a... | the views expressed are those of the author and may not necessarily reflect the views of the editorial board.abstract : this essay is an opinion article addressed to the busy practitioner .
it provides information on nutrition , diet , nutritional science , and obesity to serve as a reference in teaching his patients... |
cardiovascular diseases ( cvds ) are currently the major cause of mortality and morbidity around the world . among the cvds , coronary artery disease ( cad )
coronary angiography ( cag ) is the best tool and gold standard for diagnosis of cad .
cag is an invasive procedure which is routinely used for the assessment... | background : coronary angiography is recognized as the gold test for diagnosis of coronary artery diseases . based on the literature review ,
little is known about patients expectations about this procedure .
understanding the patient 's expectations is an important way to achieve patient - centered care .
the pu... |
the nasopalatine canal ( npc ) originates from the incisive papilla in the oral cavity and opens in the floor of the nasal cavity .
the canal shape is classified based on different indices in the sagittal plane . a study by mardinger et al .
classified the canal shape into cylindrical , funnel , hourglass and banan... | background : implant placement plays a vital role in oral rehabilitation following loss of the incisors .
thus , having knowledge of anatomical variations of adjacent neurovascular structures especially the nasopalatine canal ( npc ) is essential . due to the lack of basic information in iran about the morphology of ... |
navigation - guided procedure has been widely conducted in the neurosurgical filed to perform anatomy - oriented approach8 ) .
however , the approach can not reflect the real - time intracranial image due to differential spatial displacement caused by cerebrospinal fluid drainage , volume change after surgical evacua... | objectiveobtaining real - time image is essential for neurosurgeons to minimize invasion of normal brain tissue and to prompt diagnosis of intracranial event .
the aim of this study was to report our three - year experience with a mobile computed tomography ( mct ) for intraoperative and bedside scanning.methodsa tot... |
mobile - bearing knee prostheses were designed to increase the congruity of the articular surface and decrease polyethylene wear and component loosening after total knee arthroplasty ( tka)1,2 ) .
restoration of flexion after tka is crucial for successful clinical outcome and patient satisfaction especially in easter... | purposethis study compared the results of rotating - platform high - flexion ( rp - f ) total knee arthroplasty with low contact stress ( lcs ) for clinical and radiographical assessment after a short - term period.materials and methods68 total knee arthroplasties using a rp - f and lcs system were analyzed retrospecti... |
charles bonnet syndrome ( cbs ) was first described by charles bonnet in 1769 in his 89 years old grandfather who started experiencing visual hallucinations of men , women , carriages and building after vision loss due to cataract and who was aware about the false nature of his perceptions .
it is characterized by vi... | charles bonnet syndrome ( cbs ) is not uncommon disorder .
it may not present with all typical symptoms and intact insight . here , a case of atypical cbs
is reported where antipsychotics were not effective .
patient improved completely after restoration of vision . |
a 62-year - old man ( 169 cm in height and 69 kg in weight ) was admitted to hospital with dizziness and paresthesia of both hands .
he was diagnosed with cerebral infarction , and while doing additional examination , cerebral infarction was assumed to be due to infective endocarditis .
he was scheduled to have mit... | minimally invasive cardiac surgery ( mics ) requires lung isolation .
lung isolation is usually achieved with double - lumen endotracheal tube ( dlt ) .
patients with idiopathic thrombocytopenic purpura ( itp ) have an increased risk of bleeding events .
we suspected endobronchial hemorrhage after exchange of dlt... |
upon myocardial infarction , cardiomyocytes are lost and scar tissue is formed . to compensate this loss , cardiac hypertrophy and morphological remodelling responses try to restore the cardiac output , but can ultimately lead to heart failure .
heart transplantation is currently the only treatment option , but the n... | abstractpatients suffering from heart failure as a result of myocardial infarction are in need of heart transplantation .
unfortunately the number of donor hearts is very low and therefore new therapies are subject of investigation .
cell transplantation therapy upon myocardial infarction is a very promising strate... |
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