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subcutaneous panniculitis - like t - cell lymphoma ( sptl ) is a rare subgroup of primary cutaneous t - cell lymphoma with major manifestation in the subcutaneous tissues .
histologically , sptl is characterized by infiltration of pleomorphic t cells in the subcutis , mimicking lobular panniculitis [ 2 , 3 ] .
give... | subcutaneous panniculitis - like t - cell lymphoma ( sptl ) of the / type is a rare subtype of non - hodgkin 's lymphoma of the skin .
although these tumors usually run an indolent course , disease - related morbidity is often severe .
clinical findings include subcutaneous tumors located on the extremities or trun... |
cardiac procedures have some of the highest risks of bleeding , with almost 50% of patients experiencing some type of bleeding - related consequence.1 other common surgical procedures have bleeding rates ranging from < 10% to 35%.1 uncontrolled bleeding is associated with increased risk of death,2 blood transfusions , ... | backgroundadjunctive hemostats are used to assist with the control of intraoperative bleeding .
the most common types are flowables , gelatins , thrombins , and oxidized regenerated celluloses ( orcs ) . in the us , surgicel products are the only us food and drug administration - approved orcs.objectiveto compare the... |
helminths have developed a unique evolutionary dialogue with their hosts ' immune system due to their longevity within the host , their complex life cycles , and multicellular nature .
these pathogens induce very different immune responses in comparison to bacteria , fungi , viruses , or protozoa .
cells of the inn... | helminths are master regulators of host immune responses utilising complex mechanisms to dampen host protective th2-type responses and favour long - term persistence .
such evasion mechanisms ensure mutual survival of both the parasite and the host . in this paper
, we present recent findings on the cells that are ... |
while opportunistic infections continue to be enameled care of patients infected with acquired immunodeficiency , cancer remains overlooked in the care of these patients in developing countries . according to center disease control ( cdc ) ,
the revised definition of aids criteria includes the biological criteria ( c... | aim . to determine the prevalence of hiv infection among patients seen at the surgical oncology unit of donka ( conakry , guinea )
. method .
we conducted a retrospective and descriptive study of hiv infection in cancer patients from may 2007 to december 2012 .
social characteristics ( age , gender , marital stat... |
interest in tomosynthesis and its clinical applications has been revived by recent advances in digital x - ray detector technology . in tomosynthesis , an x - ray tube and an x - ray receptor
tomosynthesis captures only one set of discrete x - ray projections that can be used to reconstruct any plane of the object re... | the purpose of this paper is to identify indications for volumetric x - ray digital linear tomosynthesis ( dlt ) with single- and dual - energy subtraction techniques for artificial pulmonary nodule detection and compare x - ray dlt , x - ray digital radiography , and computed tomography . |
endothelial dysfunction causes different disorders in human body including preeclampsia during pregnancy . the pathogenesis may be due to inflammatory responses that trigger pregnancy - induced hypertension consequently
preeclampsia complicates up to 510 and 3% of pregnancies in developed and developing countries , r... | background : preeclampsia complicates up to 3% of pregnancies in developing countries .
endothelial dysfunction plays an important role in pathogenesis of preeclampsia . in this study
, we aim to evaluate the effect of low - dose aspirin on endothelial dysfunction in preeclamptic patients.materials and methods : in... |
eyfp - actin and eyfp - nls - actin expression plasmids were kindly provided by primal de lanerolle ( university of illinois , chicago ) .
eyfp tagged actin behaves like an endogenous actin and has been used to visualize actin dynamics in the inner cells .
we have confirmed that the expressed eyfp - nls - actin ... | actin , an integral component of the cytoskeleton , plays crucial roles in a variety of cell functions , including cell migration , adhesion , polarity and shape change .
studies performed during the last couple of decades have revealed that the actin also exists in the nucleus .
however , the function and properti... |
urticaria is a condition characterized by localized or widespread pruritic wheals that typically exist for no more than 24 h. by definition acute urticaria lasts no longer than six weeks , whereas chronic urticaria lasts longer , often several years .
autoimmune urticaria is not a well - defined term but it is genera... | omalizumab is a recombinant humanized monoclonal antibody that blocks the high - affinity fc receptor of ige .
omalizumab has been approved for the treatment of moderate to severe asthma ; however , there is currently more and more data showing promising results in the management also of chronic urticaria .
we pres... |
post - laser - assisted in situ keratomileusis ( lasik ) ectasia ( ple ) consists of progressive corneal steepening with stromal thinning due to a reduction in biomechanical stability of the cornea.14 although ple is a rare adverse outcome of laser refractive surgery , it is a significant sight - threatening complicati... | purposecollagen cross - linking ( cxl ) for post - laser - assisted in situ keratomileusis ( lasik ) ectasia ( ple ) is traditionally performed either epi - on or epi - off on the corneal surface .
this study describes a novel technique in treating early ple with under - flap cxl ( ufcxl ) to the stromal bed and repo... |
point - of - care ( poc ) is , essentially , the delivery of care wherever the patient may be and a point - of - care technology is defined as a technology that is used for bringing care to the patient rather than taking the patient to care . realizing the full potential of point - of - care technologies ( poct ) repre... | to advance the development of point - of - care technology ( poct ) , the national institute of biomedical imaging and bioengineering established the poct research network ( poctrn ) , comprised of centers that emphasize multidisciplinary partnerships and close facilitation to move technologies from an early stage of d... |
wegener 's granulomatosis or granulomatosis with polyangiitis ( gpa ) is a multisystem autoimmune disease of unknown aetiology .
its hallmark features include necrotizing granulomatous inflammation and pauci - immune vasculitis in small and medium - sized blood vessels of the respiratory tract and renal tract .
gpa... | backgroundgranulomatosis with polyangiitis ( gpa ) ( formerly known as wegener 's granulomatosis ) is a multisystem autoimmune disease of unknown aetiology .
renal disease manifests as a crescentic glomerulonephritis , with varying degrees of renal failure .
ten percent of patients progress to end - stage kidney di... |
leptomeningeal carcinomatosis ( lmc ) is defined as a diffuse or multifocal malignant infiltration of the pia matter and arachnoid membrane .
it is clinically diagnosed in 510% of all cancer patients [ 1 , 2 ] .
the most commonly reported cancers associated with lmc are breast , lung , and hematological malignancie... | leptomeningeal carcinomatosis ( lmc ) is a diffuse or multifocal malignant infiltration of the pia matter and arachnoid membrane .
the most commonly reported cancers associated with lmc are breast , lung , and hematological malignancies .
patients with lmc commonly present with multifocal neurological symptoms .
... |
muscle biopsies ( 50100 mg ) were obtained from the vastus lateralis of lean ( bmi 22.4 0.9 kg / m ; n = 12 ) and extremely obese ( bmi 45.3 1.4 kg / m ; n = 9 ) women with the percutaneous needle biopsy technique .
satellite cells were isolated and cultured into myoblasts as previously described ( 18,19 ) . after ... | objectiveto determine whether the obesity - related decrement in fatty acid oxidation ( fao ) in primary human skeletal muscle cells ( hskmc ) is linked with lower mitochondrial content and whether this deficit could be corrected via overexpression of peroxisome proliferator
activated receptor- coactivator-1 ( pgc-1)... |
a 35-year - old male , diagnosed with obsessive - compulsive disorder ( ocd ) for the past 5 years was prescribed on fluoxetine up to 80 mg / day .
he was receiving this treatment for the past 1 year with partial improvement of symptoms despite adequate compliance .
cognitive behavior therapy was not possible due t... | melasma is a hyperpigmented dermatological condition common in females .
drugs such as steroids , cosmetics , and photosensitizing agents are known to cause melasma .
we report here a case of an adult male with obsessive - compulsive disorder , receiving clomipramine , who developed melasma . |
research is pivotal in the practice and development of medicine . it helps to discover new evidence , provides impetus to further research , draws attention to areas of interest and is instrumental in improving and innovating patient care .
the results obtained from research can be made available to the medical commu... | background : to assess the quality of research presentations made in conferences , its success or failure to be published in a peer - reviewed journal is a well - accepted marker .
however , there is no data regarding the publication of research presentations made in indian conferences of anesthesiology.objective:the... |
in the previous issue of critical care nathani and colleagues have assessed kl-6 , a specific marker of type 2 alveolar epithelial cell injury , as a biomarker in acute lung injury ( ali ) .
biomarkers allow identification of patients at risk of developing disease or can be used as surrogate measures for clinical out... | studies have indicated that measuring biochemical measures of epithelial injury in plasma and alveolar fluid may be useful in predicting outcome in acute lung injury .
the present commentary briefly reviews the evidence supporting the use of these biochemical biomarkers of epithelial injury in acute lung injury , and... |
autoimmune pancreatitis ( aip ) is a distinct type of pancreatitis with a presumed autoimmune etiology .
its clinical features , treatment , and prognosis are significantly different from those of non - aip chronic pancreatitis ( cp ) .
presently , epidemiological information about aip mainly comes from japan , sou... | backgroundautoimmune pancreatitis ( aip ) is a distinct type of pancreatitis associated with a presumed autoimmune mechanism .
the aim of this study was to analyze the clinical features and expressions of forkhead box p3 ( foxp3 ) and interleukin-17 ( il-17 ) in type 1 aip in china and to identify factors for differe... |
the relatively small and non - repetitive nature of microbial genomes , coupled with the rapid advancement of sequencing technology in the last decade , have led to the generation of a staggering amount of bacterial genome records .
the national center for biotechnology information ( ncbi ) genome database currently ... | the last 20 years of advancement in sequencing technologies have led to sequencing thousands of microbial genomes , creating mountains of genetic data . while efficiency in generating the data improves almost daily , applying meaningful relationships between taxonomic and genetic entities on this scale requires a struc... |
visual field assessment is a valuable test in the neuro - ophthalmology clinic for determining presence of visual field deficit , aiding localisation of pathological lesion , and for recording improvement , stabilization , or deterioration of the underlying condition .
static perimetry is often undertaken with the hu... | aim . to compare semikinetic perimetry ( skp ) on octopus 900 perimetry to a peripheral static programme with humphrey automated perimetry
. methods .
prospective cross - section study comparing humphrey full field ( ff ) 120 two zone programme to a screening protocol for skp on octopus perimetry .
results were i... |
the online version of this article ( doi:10.1007/s11032 - 013 - 9929 - 6 ) contains supplementary material , which is available to authorized users .
supplementary material 1 ( pdf 29 kb ) supplementary material 2 ( pdf 87 kb ) supplementary material 3 ( pdf 299 kb ) | high fruit and wine quality combined with good climatic adaptation and disease resistance are essential objectives of grape breeding
. while several molecular markers are available for pyramiding resistance to fungal pathogens , molecular tools for predicting fruit composition are still scarce .
muscat flavor , cau... |
aric is a longitudinal study of 15,792 adults aged 4564 years at enrollment in 19871989 in four communities : forsyth county , nc ; jackson , ms ( african americans only ) ; the northwestern suburbs of minneapolis , mn ; and washington county , md .
participants attended three subsequent examinations approximately ev... | objectivewe examined the association between high blood pressure and incident type 2 diabetes in african americans and whites aged 3554 years at baseline.research design and methodswe combined data from the atherosclerosis risk in communities ( aric ) study , the coronary artery risk development in young adults ( cardi... |
empowerment of women and improvement of their conditions and positions in the society are the salient issues to achieve mental health .
body image is one of the important psychological concepts , which has always been a concern for men and women .
body image is a subjective concept and one of the important concepts... | background : body image is related to cognitive , emotional , and physical aspects of women 's life .
therefore , it is expected to have an important role in women 's sexual health and marital adjustment too .
this issue seems to be salient in infertile women who suffer from psychological consequences of infertilit... |
a nonhealing corneal ulcer is defined as an ulcer which does not show any indication of healing within two weeks , despite the administration of proper medical treatment .
suspicious causes of a nonhealing corneal ulcer include persistent infection , neurotrophic keratopathy , exposure keratopathy , dry eye , treatme... | introduction . the objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation ( amt ) in treating nonhealing corneal ulcers .
material and methods .
eleven patients ( 11 eyes ) with nonhealing corneal ulcer who underwent the combined surger... |
we review 4 patients with severe gbs and one patient with miller fisher syndrome ( mfs ) admitted to our institution from 2012 to 2013 .
all patients received very high - dose ivig ( total dose of at least 4 g / kg , equivalent to 2 standard treatment courses [ 2 g / kg ] ) administered over fewer than 14 days . all ... | objective : we describe an underrecognized side effect of high - dose iv immunoglobulin ( ivig ) , hemolytic anemia.background:there are no established guidelines on treating patients with guillain - barr syndrome ( gbs ) who relapse or do not improve after a standard course of treatment ( ivig or plasma exchange ) .
... |
the effective administrators are those who dedicate themselves to success of the organization not showy presentation of their own achievements ( 1 ) .
while narcissism is a disordered sense of self - admiration ( 2 , 3 ) , self - confidence was always a necessary psychological need , which has recently changed into a... | backgroundself - confidence is a glorious feature of an effective administrator .
their main goal is the organizational success .
therefore , we approached this idea by evaluating the self - confidence of nursing administration in tehran university of medical sciences ( tums ) teaching hospitals and its relation to... |
malignant transformation may occur in mftthis malignant change denotes loss of heterozygosity in clyd genethe differentiation between bcc and immature te represents a diagnostic challenge
malignant transformation may occur in mft this malignant change denotes loss of heterozygosity in clyd gene the differentiation b... | trichoepithelioma ( te ) is a benign tumor of follicular origin that presents as small , skin - colored papules predominantly on the face . when more than one family member is affected , the disease is known as multiple familial trichoepithelioma ( mft ) .
it is a rare autosomal dominant ( ad ) skin disease .
malig... |
sertoli - leydig cell tumours ( sclts ) are rare sex - cord stromal tumors of the ovary .
retiform sclt 's are rare histological variant of sclt with an average age of presentation being 16 years . to the best of our knowledge
the retiform variant of sertoli leydig tumors reported so far are seen in less than 10 ye... | sertoli - leydig cell tumors are the uncommon sex - cord stromal tumors of the ovary .
we report a case of 42-year - old female with retiform variant of sertoli - leydig cell tumour .
she presented with the complaint of mass in abdomen for 7 years .
ultrasound revealed bilateral ovarian mass suggestive of maligna... |
the term taxonomy is used to describe the classification of various things , so the term drug taxonomy refers to the science of listing and describing drugs , according to various properties , in a manner which allows easy comprehension and understanding of their usage .
traditionally , only pharmaceutical proper... | this article describes a number - based system for the classification of insulin regimes .
it utilizes a patient - centered variable ( number of injections per day ) and pharmacokinetic / dynamic characteristics to craft a taxonomic system that is able to incorporate all available insulin preparations and coformulati... |
honey has been reported to show a significant antibacterial activity against a wide range of bacteria .
it has been demonstrated in many studies that the antibacterial effects of honey are attributed to its high osmolarity , low ph , hydrogen peroxide content , and other non - peroxide factors such as lysozyme , phen... | background : honey has previously been shown to have wound healing and antimicrobial properties , but this is dependent on the type of honey , geographical location , and flower from which the final product is derived .
we tested the antimicrobial activity of a natural honey originating from the ziziphus spina - chri... |
diphthamide , the
target of diphtheria toxin , is a unique posttranslational
modification on translation elongation factor 2 ( ef2 ) in archaea and
eukaryotes .
the biosynthesis of diphthamide was proposed to involve
three steps .
the first step is the transfer of the 3-amino-3-carboxypropyl
group from s ... | |
the prostamide bimatoprost 0.03% and the prostaglandin analogs travoprost 0.004% and latanoprost 0.005% are ocular hypotensive lipids , the newest class of drugs indicated for the lowering of intraocular pressure ( iop ) in patients with glaucoma and ocular hypertension .
these medications , administered once daily ,... | objectiveto evaluate efficacy and patient preference retrospectively among intraocular pressure ( iop)-lowering prostamide and prostaglandin medications in a real - world clinical setting.methodschart review of patients with uncontrolled glaucoma or ocular hypertension seen at a private practice clinic ( n = 55 ) who r... |
personalized medicine has gained a lot of attention in recent years with improved understanding of the contribution of genetic factors to benign and malignant diseases and responses to pharmacological interventions , and the availability of a wide spectrum of genetic tests at low costs .
although the term " personali... | there are seven approved drugs for treatment of hepatitis b. professional guidelines provide a framework for managing patients but these guidelines should be interpreted in the context of the individual patient 's clinical and social circumstances .
personalized management of hepatitis b can be applied based on predi... |
congenital pouch colon ( cpc ) is an unusual abnormality in which a pouch - like dilatation of a shortened colon is associated with an anorectal malformation ( arm ) .
this report describes a girl with type - iii cpc and uterus didelphys with a septate vagina . at puberty , the child had primary amenorrhea that was f... | this report describes a girl with congenital pouch colon ( cpc ) , uterus didelphys with septate vagina , and a cloacal anomaly .
the girl underwent cloacal reconstruction at the age of 15 months .
subsequently , at puberty , the child had primary amenorrhea with severe cyclic abdominal pain due to endometriosis of... |
solid pseudopapillary tumor ( spt ) of the pancreas has been variously designated as solid and cystic tumors , solid and papillary epithelial neoplasms , papillary cystic neoplasms , papillary cystic tumors , and frantz 's tumors .
the world health organization renamed this tumor as spt in the international histologi... | solid pseudopapillary tumor of the pancreas is a rare tumor that affects young females with low malignant potential and good prognosis with more than 90% survival at 5 years .
metastasis is very rare .
we report the case of a 74-year - old female who had pancreatic solid - pseudopapillary tumor and synchronous hepa... |
the choroid plays several important functions within the eye , providing metabolic support to retinal pigment epithelium ( rpe ) and outer retina , contributing to the blood vascularization of the preliminary portion of the optic nerve and absorbing excess of light entering the retina and rpe thanks to the presence of ... | to portray usher syndrome type 2 , analyzing choroidal thickness and comparing data reported in published literature on rp and healthy subjects .
methods .
20 eyes of 10 patients with clinical signs and genetic diagnosis of usher syndrome type 2 .
each patient underwent a complete ophthalmologic examination inclu... |
nursing education aims to provide an appropriate level of knowledge and skills in nursing students .
improving the quality of nursing care requires obtaining high levels of knowledge and skills during nursing training period ( 1 ) .
however , skills acquisition is a complex process and needs students to acquire a c... | background : development of practical skills in the field of nursing education has remained a serious and considerable challenge in nursing education . moreover , newly graduated nurses may have weak practical skills , which can be a threat to patients safety.objectives:the present study was conducted to compare the ef... |
retinoblastoma is the most common intraocular tumor of childhood and accounts for 11% of all cancers that occur during the first year of life ( 1 ) . because treatments for retinoblastoma cure over 90% of patients , organ and vision preservation and the minimization of late treatment side - effects are important second... | the authors reviewed their experiences of external beam radiotherapy ( ebr ) as an initial treatment in retinoblastoma patients to determine its long - term effect on subsequent tumor control and complications .
a total of 32 eyes in 25 patients that underwent ebr for retinoblastoma were reviewed retrospectively .
... |
vascular complications include hematoma , pseudoaneurysm , arteriovenous ( av ) fistula , thromboembolism , arterial laceration and infection3,4,9 ) .
it is important to know the risk of complications and how to avoid possible causes that may cause such problems .
the presence of an accessory renal artery is not un... | vascular complications after percutaneous angiography include hematoma , pseudoaneurysm , arteriovenous fistula , thromboembolism , arterial laceration and infection .
hematomas may occur in the groin , thigh , retroperitoneal , intraperitoneal , or abdominal wall .
a 54-year - old female underwent percutaneous tra... |
world health organization ( who ) estimated that over 237 million people required treatment for schistosomiasis in 2010 with estimates of up to an additional 779 million at risk globally .
schistosomiasis is endemic in 76 countries worldwide and besides malaria is the second important parasitic disease for public h... | the objectives of this study was to conduct a survey on schistosomiasis and soil - transmitted helminth ( sth ) infections in order to come up with feasible control strategies in lake victoria basin , tanzania .
depending on the size of the school , 150 - 200 schoolchildren were recruited for the study .
duplicate ... |
linkage analyses performed in the early 1990s and centered on early onset alzheimer s disease families identified the only fully penetrant mutations known to date to be involved in this disease .
three genes were found to carry these mutations : app , psen1 and psen2 ( amyloid beta ( a4 ) precursor protein , presenil... | the analyses of genetic factors contributing to alzheimer s disease ( ad ) and other dementias have evolved at the same pace as genetic and genomic technologies are developed and improved .
the identification of the first genes involved in ad arose from family - based studies , but risk factors have mainly been ident... |
recent clinical studies have shown that treatment with angiotensin ii type 1 ( at1 ) receptor blockers or angiotensin - converting enzyme ( ace ) inhibitors protects against the development of insulin resistance in hypertensive patients and new onset of diabetes in at - risk patients , indicating that the renin - ang... | handle region peptide ( hrp ) , which was recognized as a blocker of ( pro)renin receptor ( ( p)rr ) , may block the function of ( p)rr .
the aim of this study was to investigate the effect of hrp with a large dose of 1 mg / kg / d on glucose status in the rats treated neonatally with monosodium l - glutamate ( msg ... |
a modified gyrb cdna fragment was generated as previously described ( 10 ) and ligated at the 3 end of a human l - selectin cdna ( 11 ) via an xbai site introduced at the l - selectin translation - termination codon .
all constructs were verified by dna sequencing , subcloned into the pmt-2 expression vector ... | l - selectin binding activity for its ligand expressed by vascular endothelium is rapidly and transiently increased after leukocyte activation . to identify mechanisms for upregulation and assess how this influences leukocyte
/ endothelial cell interactions , cell - surface dimers of l - selectin were induced usi... |
the ev surveillance system in south korea consists of 62 clinics ( 8 primary clinics , 14 secondary hospitals , and 40 tertiary hospitals located nationwide ) managed by pediatric physicians ( figure ) . during 2009 ,
a total of 2,427 cases of viral disease were reported to the korea centers for disease control and p... | we assessed neurologic sequelae associated with an enterovirus 71 ( ev71 ) outbreak in south korea during 2009 .
four of 94 patients had high signal intensities at brainstem or cerebellum on magnetic resonance imaging .
two patients died of cardiopulmonary collapse ; 2 had severe neurologic sequelae .
severity an... |
cronkhite - canada syndrome ( ccs ) is a rare nonfamilial polyposis syndrome characterized by two kinds of marked epithelial disturbances .
the first is epidermal manifestations including alopecia , onychodystrophy , and hyperpigmentation , and the second is gastrointestinal tract expressions involving hamartomatous ... | cronkhite - canada syndrome ( ccs ) is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances both in the gastrointestinal tract and in the epidermis .
the pathologic finding of the polyp is usually a hamartomatous polyp of the juvenile type ; however , the possibility of serrated adenoma asso... |
antiretroviral therapy ( art ) suppresses efficiently the replication of human immunodeficiency virus type 1 ( hiv-1 ) to undetectable levels with standard techniques in most treated patients , but there is still an ongoing low - grade replication in most or all patients .
also , immune activation is a central featur... | objective . we hypothesized that hmgb1 in complex with bacterial components , such as flagellin , cpg - odn , and lps , promotes hiv-1 replication .
furthermore , we studied the levels of antiflagellin antibodies during hiv-1-infection . methods .
chronically hiv-1-infected u1 cells were stimulated with necrotic ex... |
fragile x syndrome ( fxs ) is the most common mental disorder caused by a cgg trinucleotide amplification on xq27.3 in the 5 untranslated region of fmr1 gene cloned and named in 1991 , which suppresses production of fragile x mental retardation protein ( fmrp ) [ 1 , 2 ] .
fmrp is widely expressed in neuron and glia ... | fragile x syndrome ( fxs ) is an inheritable neuropsychological disease caused by expansion of the cgg trinucleotide repeat affecting the fmr1 gene on x chromosome , resulting in silence of the fmr1 gene and failed expression of fmrp .
patients with fxs suffer from cognitive impairment , sensory integration deficits ... |
a single examination does not fulfill all the functions of assessment , such as assessing knowledge , comprehension , skills , motivation , and feedback .
written examinations ( essays and multiple choices ) test cognitive knowledge , which is only one aspect of the competency .
structuring of questions and assessm... | background : undergraduate medical examination is undergoing extensive re evaluation with new core educational objectives being defined .
consequently , new exam systems have also been designed to test the objectives .
objective structured practical examination ( ospe ) is one of them.objectives:to introduce ospe a... |
an ongoing outcomes follow - up project with a prospective inception cohort in western canada was started in 1996 . as described previously , infants were identified at the time of complex cardiac surgery and were followed prospectively.11 in this study , we included all infants aged 6 weeks who were admitted to the p... | backgroundwe aimed to determine whether sepsis is associated with neurocognitive outcomes 4.5 years after congenital heart disease surgery in early infancy.methods and resultsa secondary analysis from a prospective inception cohort included all children having congenital heart disease surgery done at 6 weeks of age wit... |
hypertension is an important worldwide public - health challenge because it is one of the most common chronic conditions [ 1 , 2 ] .
the prevalence of hypertension in sub - saharan africa is between 12.5 and 26.9% . in 2005
the world health organization stepwise approach to surveillance of noncommunicable diseases ... | background .
since the treatment of hypertension is beneficial for the elderly , we have undertaken this study that aims to evaluate the management of hypertension in elderly patient in cte d'ivoire .
methods .
a retrospective study was conducted among 854 hypertensive elderly patients of abidjan cardiology insti... |
in the case of older adults over 65 years of age , physiological changes caused by aging
lead to much greater vulnerability with regard to safety issues compared to younger age
groups1 . due to physiological changes
resulting from aging , elders face a 10 times greater risk of falls than those in other age
gro... | [ purpose ] this research aims to identify the relationships among visual perceptual
skills , cognitive functioning , and fall efficacy of older adults based on whether they are
at risk for falls .
[ subjects and methods ] subjects included 116 older adults over 65 years
of age who use d seniors welfare center... |
it is the fourth most common form of cancer in the us and the third leading cause of cancer - related death in the western world . in patients with localized disease ,
standard treatment includes surgical resection of the tumor , followed by adjuvant chemotherapy in case of regional lymph node metastases .
though c... | colorectal carcinomas are among the most common tumor types and are generally treated with palliative chemotherapy in case of metastatic disease . here , we describe the case of a 46-year - old patient with metastatic rectal carcinoma who received second - line therapy with irinotecan and developed isolated transient d... |
human adult gut microbiota is estimated to consist of up to 100 trillion microorganisms , comprising at least 500 different species , mostly anaerobic bacteria .
although the advent of modern molecular microbiological methods has expanded the degree of bacterial detection from stool samples , it does not allow for th... | clostridium phoceensis sp . nov .
, strain gd3 t (= csur p1929 = dsm 100334 ) is the type strain of c. phoceensis sp . nov .
, a new species within the genus clostridium .
this strain was isolated from the gut microbiota of a 28-year - old healthy french man .
c.
phoceensis is a gram - negative , spore - f... |
primary cutaneous malignant melanoma ( cmm ) is an increasingly frequent malignancy in the white population of western countries .
the tumour size is closely associated with cell proliferation including the size of the growth fraction [ 2 , 3 ] . in recent years
, some progress has been reached in the understanding... | the homeobox family and its subset of hox gene products represent a family of transcription factors directing dna - protein and protein - protein interactions . in the embryo , they are central regulators in cell differentiation during morphogenesis . a series of genes of the four hox gene clusters a , b , c , and d we... |
the mortality rate following neurosurgical treatment of an unruptured cerebral aneurysm varies from 0.4% to 1.5% , and age of the patient and size and location of the aneurysm are generally accepted factors that affect surgical outcome.9 ) for achievement of acceptable surgery - related morbidity and mortality rates , ... | objectiveatherosclerotic cerebral aneurysms are known to increase occurrence of thromboembolic events and occlusion of perforator vessels intraoperatively due to pathological changes in the vessels themselves . in the current study
, we analyzed the points to be considered during surgery for atherosclerotic cerebral ... |
preeclampsia is the most frequently encountered medical complication of pregnancy , causing considerable maternal and fetal morbidity and mortality ( 1 ) .
preeclampsia affects approximately 5% of all pregnancies and in up to 10% to 20% of nulliparous women ( 2 ) . despite intensive studies ,
placental ischemia cau... | backgroundpreeclampsia is a pregnancy - specific syndrome that may be life - threatening , especially to the fetus .
several causes have been reported that may have a possible role in the development of the disorder . interleukin-10
affect maternal intravascular inflammation , as well as endothelial dysfunction .
... |
bartonella species are gram - negative , facultative intracellular bacilli , and the genus includes more than 20 species or subspecies . among these species and subspecies ,
bartonella henselae is the primary species that causes human illnesses , including lymphadenopathy , bacteremia , bacillary angiomatosis , and o... | bartonella henselae causes cat - scratch disease , bacteremia , and various focal infections . despite the worldwide occurrence of b. henselae infections , reports in humans
are rare in korea .
the clinical manifestation of all 5 previously reported cases was lymphadenopathy . herein , we report a case of bacteremi... |
influenza is potentially fatal in the elderly , as it can be complicated by pneumonia and other serious diseases in this subpopulation . in several studies ,
influenza vaccination in the elderly has been reported to reduce influenza - associated mortality by 3954% and pneumonia - associated hospitalization by 2773% 1... | key clinical messagewe report a case of an elderly man who developed myositis of the deltoid muscle 8 days after influenza vaccination .
adverse reactions to influenza vaccine are generally immediate reactions .
however , delayed - type hypersensitivity reactions , although rare , can occur after routine influenza... |
the spiritual dimension of humans has a multidimensional and complex nature with cognitive , emotional , and behavioral aspects .
the emotional dimension of spirituality mixes with individual hope , love and dependence , internal peace , comfort , support , and experiences .
behavioral aspects include inner spiritu... | background : spiritual care is an important part of health - care provision .
spiritual care can improve patients ' health .
one of the requirements for providing appropriate spiritual care for patients is having the required competence.aim:this study was conducted to investigate the perception of health - care pro... |
venoarterial extracorporeal membrane oxygenation ( va - ecmo ) can maintain hemodynamic stability in the absence of an intrinsic cardiac rhythm or effective cardiac output and provide excellent mechanical circulatory support in such urgent or emergent situations .
va - ecmo has been shown to be effective in patients ... | a healthy teenage japanese girl was admitted to our hospital after experiencing out - of - hospital cardiac arrest .
she had attempted to commit suicide by taking 4,950 mg of disopyramide and 12 mg of flunitrazepam .
mechanical cardiopulmonary support was started with percutaneous cannulation of the femoral vessels... |
neuropeptides are a subclass of peptides
that can function as neuromodulators ,
neurotransmitters and hormones and have a critical role in many biological
processes such as growth , learning , memory , metabolism and neuronal
differentiation and disorders such as depression , parkinson s
disease , and eating ... | neuropeptide identification in mass spectrometry experiments
using
database search programs developed for proteins is challenging . unlike
proteins
, the detection of the complete sequence using a single spectrum
is required to identify neuropeptides or prohormone peptides .
this
study compared the perfor... |
in addition to transmission of genetic information from dna to proteins , rna is capable of performing a wide range of biological functions in cells , including catalysis , genetic control and molecular recognition ( 1 ) . because the functions of rnas are largely determined by their diverse three - dimensional ( 3d ) ... | since its first release in 2010 , iparts has become a valuable tool for globally or locally aligning two rna 3d structures .
it was implemented by a structural alphabet ( sa)-based approach , which uses an sa of 23 letters to reduce rna 3d structures into 1d sequences of sa letters and applies traditional sequence al... |
polycystic liver disease ( pld ) is a genetic inherited entity associated with polycystic renal disease due to mutations in pkd1 or pkd2 genes .
surgical intervention is needed in cases presenting with massive hepatomegaly , or when complications such as cyst rupture , infection , hemorrhage or jaundice occur .
obs... | although jaundice rarely complicates polycystic liver disease ( pld ) , secondary benign or malignant causes can not be excluded . in a 72-year - old female who presented with increased abdominal girth , dyspnea , weight loss and jaundice , ultrasound and computed tomography confirmed the diagnosis of pld by demonstrat... |
one of the six main strategies recommended by the world health organization ( who ) ( mpower ) for controlling the epidemic of tobacco use was providing smoking cessation services for individuals who are dependent upon tobacco .
according to article 14 of the who framework convention on tobacco control , these servic... | background : in recent years , electronic cigarettes ( ecs ) have been heavily advertised as an alternative smoking device as well as a possible cessation method .
we aimed to review all published scientific literature pertaining to ecs and to present a simple conclusion about their effects for quitting smoking and r... |
we report a case of hairy cell leukemia ( hcl ) initially misdiagnosed as plasma cell dyscrasia due to various clinical , morphological and immunophenotypic confounders .
in a patient diagnosed of marrow plasmacytosis and serum monoclonal protein elsewhere and referred to our hospital , morphological evaluation of bo... | objectiveswe report a case of hairy cell leukemia ( hcl ) initially misdiagnosed as plasma cell dyscrasia due to various clinical , morphological and immunophenotypic confounders.methods and resultsin a patient diagnosed of marrow plasmacytosis and serum monoclonal protein elsewhere and referred to our hospital , morph... |
one common procedure to translate a tooth in the dental arch is sliding it along an arch - wire , which is associated with advantages such as decreased clinical treatment time , patient satisfaction , and three - dimensional control of tooth movements .
however , a frictional force between the bracket and wire is una... | background : in the sliding technique , the reduced frictional forces are associated with rapid tooth movements and better control of the anchorage . recently , wire coating with different nanoparticles has been proposed to decrease frictional forces .
this in vitro study was carried out to coat stainless steel ( ss ... |
composite transposons are common mobile genetic elements ( mges ) responsible for the dissemination of genes responsible for bacterial adaptation and survival including those conferring antibiotic resistance and xenobiotic degradation ( nojiri , shintani and omori 2004 ; bennett 2008 ) .
they consist of two insertion... | a composite transposon is a mobile genetic element consisting of two insertion sequences ( iss ) flanking a segment of cargo dna often containing antibiotic resistance ( ar ) genes .
composite transposons can move as a discreet unit .
there have been recently several reports on a novel mechanism of movement of an i... |
beta - catenin - dependent signaling pathways play essential roles in various cellular processes and in normal tissue homeostasis . although -catenin was primarily known as a central component of the canonical wnt signaling , several other signaling pathways like those mediated by tyrosine kinases , pi3-kinases , and h... | background : the canonical wnt signal transduction ( or the wnt/-catenin pathway ) plays a crucial role in the development of animals and in carcinogenesis .
beta - catenin is the central component of this signaling pathway .
the activation of wnt/-catenin signaling results in the cytoplasmic and nuclear accumulati... |
although it has been
known for five decades that guanine - rich nucleic
acids can form four - stranded structures , research into quadruplex
dna has rapidly escalated in recent years .
one reason for continued
interest is the demonstration that telomeres can and do fold into
quadruplex structures in vivo . ... | we report dna binding studies of
the dinuclear ruthenium ligand
[ { ru(phen)2}2tpphz]4 + in enantiomerically
pure forms . as expected from previous studies of related complexes ,
both isomers bind with similar affinity to b - dna and have enhanced
luminescence .
however , when tested against the g - quadrup... |
microglia are a type of neuroglia that support , nurture , and
protect neurons which maintain homeostasis of the fluid that bathes neurons .
it is an innate immune component of the central
nervous system ( cns ) parenchyma . under physiological conditions , residential
microglia are quiescent and scattered ... | microglia activated in response to brain injury release neurotoxic factors including nitric oxide ( no ) and proinflammatory cytokines such as tumor necrosis factor-
( tnf- ) and interleukin-1 ( il-1 ) .
ketamine , an anesthetic induction agent , is generally reserved for use in patients with severe hypotension or... |
cancer is a multifactorial disease and is one of the leading causes of death worldwide .
the contributing factors include specific genetic background , long - term exposure to various environmental stresses , and bias diet habit .
all these risk factors finally reflect on the accumulation of molecular changes in ce... | recent advances in cancer therapy encounter a bottleneck . relapsing / recurrent disease
almost always developed eventually with resistance to the initially effective drugs .
tumor microenvironment has been gradually recognized as a key contributor for cancer progression , epithelial - mesenchymal transition of the... |
the rate of infant hiv infection in the usa has plummeted with the advent of routine hiv testing during pregnancy and the availability of potent antiretroviral therapy .
these public health advances shift focus to prevention of other comorbid conditions in hiv - infected women and their infants .
herpes simplex vir... | objective . to compare genital hsv shedding among hiv - positive and hiv - negative women . methods . women with and without known hiv infection who delivered at the university of washington medical center between 19891996 had hsv serologies done as part of clinical care .
genital swabs from hsv-2-seropositive women ... |
a four - month - old female infant presented to the emergency department of the children s hospital in winnipeg , manitoba , with full - thickness burns of the anterior lower limbs . according to the infant s mother , the burns had been sustained two weeks previously while visiting family in karachi , pakistan , when a... | a case of osteomyelitis in an infant following a burn injury sustained in pakistan caused by a ges-13-producing pseudomonas aeruginosa ( the first reported in canada ) and an oxa-48 producing klebsiella pneumoniae is described .
the present case serves to highlight the importance of international travel as a risk fac... |
essential properties
of transition - metal complexes that are intimately linked to the electronic
and steric aspects of ligands in the primary coordination sphere include
redox properties , light absorption , and emission .
additionally , in
supermolecule complexes where spatially distinct chromophores are
... | a cyclometalated iridium complex
is reported where the core complex comprises naphthylpyridine as the
main ligand and the ancillary 2,2-bipyridine ligand is attached
to a pyrene unit by a short alkyl bridge . to obtain the complex with
satisfactory purity
, it was necessary to modify the standard synthesis
... |
hairtail ( trichiurus lepturus ) , ecologically warm water fish species , belonging to family trichiuridae , widely distributed on the coast of the yellow sea , south sea and jeju island in the korean peninsula and the several sea areas in china under the natural ecosystem .
the food consumption of this species has i... | pcr analysis generated on the genetic data showed that the geographic hairtail ( trichiurus lepturus ) population from korea in the yellow sea was more or less separated from geographic hairtail population from china in the south sea .
the average bandsharing value ( meansd ) within hairtail population from korea sho... |
key clinical messagethis case demonstrates the rare coexistence of a prolactinoma with craniopharyngioma and documents its radiological growth .
this case suggests that patients with pituitary neoplasms should be followed closely and although prolactinomas can often be managed medically , a coexistent other lesion ma... | |
though pregnancy and labor are considered a physiological process the potential for catastrophic complications is constant and may develop in a matter of minutes .
. global prevalence of samm ( defined as severe life threatening obstetric complication necessitating urgent medical intervention in order to prevent like... | aim : to analyze the hdu requirement in an obstetric population in terms of utilization rate , indications for admission , interventions required and gestational outcome.setting and design : a retrospective observational study was carried out from may 2007 to may 2011 in the dept . of obstetrics and gynecology and hdu ... |
worldwide , more than 14 million new cases of cancer were diagnosed in 2012 ( ferlay et al . , 2013 ) , and
the annual number of incident cancers is expected to reach 24 million in the next two decades , reflecting population ageing , trends towards earlier detection and increasing exposure to risk factors .
it is ... | the increasing number of new cases of cancer highlights the relevance of primary prevention for cancer control , which is influenced , among other factors , by the population s health - related knowledge .
therefore , we aimed to describe cancer - related knowledge in portugal , including perception of risk , awarene... |
one
of the major infectious diseases that causes significant mortality
around the world is malaria .
currently , primaquine ( pq , figure 1 ) has been used as the drug to treat the liver stage
of this disease . however , a major concern
for primaquine is that its metabolites are able to cause hemolytic
anem... | the effect of an
exocyclic substituent on the ionization potential
of primaquine , an important antimalarial drug , was investigated using
density functional theory methods .
it was found that an electron - donating
group ( edg ) makes the ionization potential decrease .
in contrast ,
an electron - withdr... |
flightless i ( flii ) is a multifunctional protein of the gelsolin family of actin - remodelling proteins .
there are eight members of this family in mouse and humans , each containing one or two gelsolin domains consisting of three repeated gelsolin motifs of between 125 and 150 amino acids in length .
flii contai... | intracellular flightless i ( flii ) , a gelsolin family member , has been found to have roles modulating actin regulation , transcriptional regulation and inflammation . in vivo flii
can regulate wound healing responses .
we have recently shown that a pool of flii is secreted by fibroblasts and macrophages , cells ... |
to evaluate the association of elevated serum lipids with retinal hard exudates formation , the occurrence clinically significant macular edema ( csme ) , occurrence and severity of diabetic retinopathy ( dr ) and loss of vision in type 2 diabetics .
type 2 diabetic patients seeking ocular evaluation for diabetic ret... | aim : to evaluate the association of elevated serum lipids with retinal hard exudates formation , the occurrence clinically significant macular edema ( csme ) , occurrence and severity of diabetic retinopathy ( dr ) and loss of vision in type 2 diabetics.materials and methods : type 2 diabetic patients seeking ocular e... |
vaginismus is defined according to dsm iv - tr as recurrent or persistent involuntary spasm of the musculature of the outer third of the vagina , which interferes with coitus and causes distress and interpersonal difficulty .
the inclusion of spasm in the definition has been questioned as it has not been consistently... | vaginismus is defined as recurrent or persistent involuntary spasm of the musculature of the outer third of the vagina , which interferes with coitus and causes distress and interpersonal difficulty . in this report
, we describe the successful treatment of vaginismus in a 25-year - old lady based on a model proposed... |
the determination of an accurate working length is a critical step in endodontic therapy . establishing the working length at the apical constriction
the apical constriction ( minor apical diameter ) is the narrowest apical portion of the root canal with a variety of morphological variations that make its identificat... | aim : this study was designed to compare the accuracy of root zx and sybronendo mini , electronic apex locators ( eals ) , in the presence of various irrigants.materials and methods : sixty extracted , single - rooted human teeth were decoronated and the root canals coronally flared .
the actual length ( al ) was ass... |
during 20092013 , a total of 31 adult foxes with signs of a neurologic disorder were brought to the rspca norfolk wildlife hospital in east winch , united kingdom .
the foxes exhibited abnormal behavior , lack of fear , reduced alertness , aimless wandering , circling , facial muscle twitching , hind limb paresis , a... | a fox circovirus was identified in serum samples from foxes with unexplained neurologic signs by using viral metagenomics .
fox circovirus nucleic acid was localized in histological lesions of the cerebrum by in situ hybridization .
viruses from the family circoviridae may have neurologic tropism more commonly than... |
she was diagnosed with subfoveal cnv secondary to age - related macular degeneration ( amd ) and the best - corrected visual acuity of the right eye was 20/50 .
pdt with verteporfin was performed according to the standard protocol of the treatment of age - related macular degeneration with photodynamic therapy invest... | we report a case of serous retinal detachment following combined photodynamic therapy ( pdt ) and intravitreal bevacizumab injection in subfoveal choroidal neovascularization ( cnv).a 53-year - old woman was diagnosed with subfoveal cnv secondary to age - related macular degeneration ( amd ) and treated with combined p... |
to assess attitudes and practices of documentation and coding education for emergency medicine residents ( emrs ) .
questions regarding documentation teaching methods were formulated into online surveys for program directors ( pds ) and emrs .
fifty - three of 104 pds and 446 of 576 emrs who received the survey com... | purposes : to assess attitudes and practices of documentation and coding education for emergency medicine residents ( emrs).methods : questions regarding documentation teaching methods were formulated into online surveys for program directors ( pds ) and emrs.results:fifty-three of 104 pds and 446 of 576 emrs who recei... |
in 2008 a 57-year old man was referred for treatment of polycythemia vera ( pv ) .
one year earlier he had been admitted with symptoms resembling an episode of transitory cerebral ischemia ( tci ) .
the patient also had a history of multiple sclerosis ( ms ) , vitamin b12 deficiency and tobacco smoking .
the ms w... | we report a 57-year old man with polycythemia vera , who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate .
the patient was treated with this combination for 56 months , and during this period the patient has been in complete hematological remission . the jak2-v6... |
case 1 was a 6-year - old , previously healthy girl from the family of 7 siblings of consanguineous parents living in a rural area of kuwait . for the last 10 days , she complained for pain in muscles of lower limbs , clumsiness , and difficult walking .
, she had limping gait and symmetrically painful muscles on pal... | contamination or transcutaneous absorption of organophosphates ( op ) is rare and there exist only few reports of such manner of poisoning . we report four children from the same family in whom temporal proximity of the disease onset , a detailed interrogation of parents and exclusion of other clinical differentials , ... |
a drug intended for use in humans should have an ideal balance of pharmacokinetics and safety , as well as potency and selectivity .
human oral bioavailability is an important pharmacokinetic property which describes the fraction of an administered drug that reaches the systematic circulation and its site of action ,... | objective : a computational model for predicting oral bioavailability is very important both in the early stage of drug discovery to select the promising compounds for further optimizations and in later stage to identify candidates for clinical trials . in present study , we propose a support vector machine ( svm)-base... |
patients diagnosed with diffuse dme at samsung medical center between september 2003 and august 2004 were enrolled .
diffuse dme was defined as macular thickening corresponding to csme on biomicroscopy with findings of diffuse fluorescein leakage without a responsible microaneurysm on angiography and increased cmt ( ... | purposeto report the three - year outcomes of macular laser photocoagulation following intravitreal injection of triamcinolone acetonide ( ivta ) for diffuse diabetic macular edema ( dme).methodsa prospective , randomized controlled study was completed .
eighty - six eyes of 74 patients with diffuse dme were randomiz... |
dexmedetomidine , an 2 agonist , has been studied widely as an adjuvant to local anaesthetics in regional anaesthesia techniques to enhance the quality and duration of analgesia .
dexmedetomidine is highly selective ( 8 times more selective than clonidine ) and a specific 2 adrenergic agonist , having analgesic , sed... | background and aims : the ideal dose of dexmedetomidine for brachial plexus block is a matter of debate .
this study was carried out to evaluate 50 g or 100 g of dexmedetomidine added to 0.5% levobupivacaine , with regard to the duration of analgesia .
our study also sought to assess the onset and duration of senso... |
aseptic technique should be used for all survival surgical procedures . disinfect the surgical work surface with commercial disinfectant and prepare sterile surgical packs of instruments , drapes , gauze , swabs , sutures , and scalpel blades by autoclaving . a surgical mask , hair bonnet and sterile gloves should be w... | stroke is the leading cause of disability and the third leading cause of death in adults worldwide1 . in human stroke
, there exists a highly variable clinical state ; in the development of animal models of focal ischemia , however , achieving reproducibility of experimentally induced infarct volume is essential .
... |
the contura multi - lumen balloon ( mlb ) by senorx is a five - channel breast brachytherapy balloon developed for accelerated partial breast irradiation ( apbi ) using high dose rate iridium-192 .
the device is designed to improve upon the utility of single channel breast brachytherapy by offering multiple channels ... | purposea study was conducted to determine the dosimetric effects resulting from air pockets and high atomic number ( z ) contrast medium within a multichannel breast brachytherapy device.material and methodsa 5 - 6 cm diameter contura ( senorx ) brachytherapy device was inflated using 37 cm3 of saline .
baseline dose... |
five of the articles deal directly or indirectly with children 's mental health matters in the context of medicaid .
this overview compares and discusses the findings of these articles in some detail before briefly outlining the remaining articles on more specialized topics .
the president 's new freedom commission... | the following overview discusses and compares the findings and implications of the articles in this issue of the health care financing review that deal with mental health topics particularly children 's mental health in the medicaid context .
it also briefly describes articles concerning prospective payments for psy... |
medulloblastoma ( mb ) is the most common malignant brain tumor in children , but in adults the disease is rare and accounts for less than 1 % of all intracranial malignancies . due to the infrequent occurrence of this disease in adults ,
not much was known until recently about the biology and genetics of adult mb a... | medulloblastoma encompasses a group of aggressively growing cancers that arise either in the cerebellum or brain stem .
they present primarily in children , with 8085 % of medulloblastomas being diagnosed in patients of 16 years and younger . in adults ,
medulloblastomas are rare and account for less than 1 % of ... |
anxiety disorders , such as post - traumatic stress disorder , social phobia , specific phobias , panic and obsessive - compulsive disorders , are among the most common mental disorders in humans ( olesen et al . , 2012 ) .
these disorders are associated with problems to extinguish learned fear responses and also to... | anxiety disorders are characterized by persistent , excessive fear . therapeutic interventions that reverse deficits in fear extinction represent a tractable approach to treating these disorders .
we previously reported that 129s1/svimj ( s1 ) mice show no extinction learning following normal fear conditioning .
we... |
globally , alcohol causes 4% of all deaths and contributes 5% to the global burden of disease .
alcohol consumption has increased globally over years and india being one of the most populous countries contributes significantly to the alcohol - attributable burden . among 1549-year - old men in india ,
the prevalenc... | background : studying personality profiles allows researchers to generate important hypotheses in risk factors and correlates of alcohol use / misuse .
studies examining the association between personality traits and treatment outcome are limited in india .
we studied the correlation between personality and treatme... |
acute liver failure ( alf ) is a critical condition that can occasionally lead to death .
ho et al . have reported that infectious diseases , alcohol abuse , and malignancy are several risk factors associated with poor prognosis in alf patients .
on - line hemodiafiltration ( olhdf ) uses a large amount of steril... | on - line hemodiafiltration ( olhdf ) is one of the treatment options in the management of acute liver failure ( alf ) in japan .
it is essential to avoid infection in the management of alf .
in fact , infection is one of the prognostic factors in alf . in this report
, we present a middle - aged japanese man wit... |
nevoid hyperkeratosis of the nipple and the areola ( nhna ) of the breast is a rare condition which is characterized by verrucose thickening and caf au lait pigmentation of the nipple and areola .
first described in the medical literature by tauber in 1923 as a benign dermatologic change in the nipple and areola , ... | nevoid hyperkeratosis of the breast is a rare condition affecting the nipple , the areola or both .
it appears in both sexes and it can by lateral or unilateral .
it can also accompany other skin diseases or systemic conditions including malignancies .
treatment may not be easy due to aesthetic consequences but s... |
caesarean section in the second stage of labour is a technically difficult procedure , especially when performed after an operative vaginal delivery has been attempted and when the fetal head is deeply impacted within the pelvis .
therefore , a second stage caesarean section may be associated with increased materna... | objectives . to review the determinants for a failed operative vaginal delivery and to examine associated fetal and maternal morbidity . design .
retrospective observational study . setting .
large london teaching hospital . method .
a retrospective review of case notes during a 5-year period was carried out .
... |
congenital hypothyroidism ( cht ) is the most common congenital endocrine disorder with a world - wide incidence around 1 in 3500 to 4000 live births .
reduced thyroid hormone production in babies with cht has a major detrimental effect on central nervous system development and growth .
most babies with cht have th... | previous studies of congenital hypothyroidism have suggested an increasing incidence and seasonal variation in incidence , which may suggest nongenetic factors involved in aetiology .
this study describes the incidence of elevated thyroid stimulating hormone ( tsh ) values in newborns , a surrogate for congenital hyp... |
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