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the world health organization ( who ) co - sponsored an international conference on primary health care in alma - ata , ussr ( now in kazakhstan ) in september 1978 .
the declaration of alma - ata stated the need for urgent action by all governments , all health and development workers , and the world community to p... | backgroundglobally there is an increase in incidence of chronic kidney diseases ( ckds ) .
diabetes mellitus ( dm ) , hypertension and stone diseases are the major risk factors for ckd .
we organized kidney disease screening camps in a semi - urban population of gujarat , india on the occasion of world kidney day (... |
mycobacterium malmoense is an acid - fast environmental non - tuberculous mycobacterium ( ntm ) that rarely causes disease in humans but is becoming increasingly clinically significant , especially within europe .
it was first described in 1977 by schroder and juhlin , following isolation in respiratory tract culture... | mycobacterium malmoense is an acid - fast non - tuberculous organism that most commonly causes pulmonary infection .
extrapulmonary infection has also been reported . with an increased emphasis being placed on the clinical importance of this organism , especially within europe , we report the first case of septic art... |
creating peptide - based drugs includes the search of active sites or functionally important sites in the target protein and the selection of peptides capable of specific interaction with these sites .
such a selection usually can be accomplished using peptide libraries containing random fragments of amino acid seque... | a mirror - symmetry motif was discovered in the n - terminus of the influenza virus pb1 protein .
structure of peptide comprised of the corresponding part of pb1 ( amino acid residues 6 - 25 ) was investigated by circular dichroism and in silico modeling .
we found that peptide pb1 ( 6 - 25 ) in solution assumes be... |
cerebral palsy is a condition in which permanent problems affect movements and postural
development due to non progressive lesions in the immature brain .
it is accompanied by
sensory disabilities , cognitive disorders , communication disorders , hypermetamorphosis ,
behavioral disorders , or convulsion1 .
am... | [ purpose ] the purpose of this study was to compare joint angles between normal children
and those with spastic diplegia using three - dimensional gait analysis .
[ subjects and
methods ] the study subjects were eight patients with spastic diplegia and eight normal
children .
three - dimensional gait analysi... |
the insulin signal transduction pathway in pancreatic -cells is similar to that in most other cell types ( fig .
1 ) . we do not dispute evidence that insulin receptors are expressed in -cells .
moreover , it is generally accepted that some elements in the insulin signal transduction pathways play a critical role... | in recent years there has been a growing interest in the possibility of a direct autocrine effect of insulin on the pancreatic -cell .
indeed , there have been numerous intriguing articles and several eloquent reviews written on the subject ( 13 ) ; however , the concept is still controversial .
although many in vi... |
several studies have shown that subjects suffering from low back pain ( lbp ) frequently show
persistent involvement of the lumbar multifidus muscle . for example , atrophy and fatty
infiltration have been reported1,2,3,4,5,6,7 , reduced activity has been
demonstrated in persistent lbp8,9,10,11 , and fiber transf... | [ purpose ] the purpose of this review was to investigate the types of exercises that can
improve the tropism of the multifidus muscles , based on clinical evidence .
[ methods ]
following to the pico ( problem , intervention , comparison , outcome ) model , we considered
studies of subjects with specific or no... |
organophosphate compounds ( opcs ) are widely used for pest control in agriculture worldwide which leads to increased risk of human exposure . as a result of easy and widespread availability
they are also often used as suicidal agents in developing countries killing an estimated 300,000 people per annum .
the opcs ... | background : organophosphate compound ( opc ) poisoning is common in the developing countries such as india .
the acute and later effects of opc poisoning on pituitary and target gland hormones is largely unknown.materials and methods : this prospective study was conducted at postgraduate institute of medical educati... |
its symptomatology could mimic other disease processes such as cholecystitis , diverticulitis , ruptured ovarian cysts and pelvic inflammatory disease .
the diagnosis could be further obscured by underlying undiagnosed anatomical anomalies , for instance intestinal malrotation .
midgut malrotation is a foetal anoma... | appendicitis is a common surgical condition with various clinical presentations .
the diagnosis could be obscured by underlying undiagnosed anatomical anomalies like intestinal malrotation .
intestinal malrotation is a rare foetal anomaly resulting from an incomplete , or failure of midgut rotation and fixation .
... |
internal hernias comprise 1% of hernias , 8% of which are through the foramen of winslow into the lesser sac .
this is the third reported case describing true gastric outlet obstruction secondary to caecal herniation through the lesser foramen .
it is common for this type of herniation to initially be misinterprete... | abstractinternal hernias comprise 1% of hernias , 8% of which are through the foramen of winslow into the lesser sac .
these hernias can mimic gastric outlet obstruction and cause associated morbidity . in this case
, we describe a caecal herniation into the lesser sac presenting as true gastric outlet obstruction ... |
the leukodystrophies are a heterogeneous group of genetic diseases involving dysmyelination of brain white matter as a result of substrate accumulation due to enzymatic defects .
recognition of leukodystrophies has been revolutionized by mri technology because of its increased sensitivity compared to ct scan and beca... | leukoencephalopathy refers to any disease of the white matter including hereditary as well as acquired and toxic causes .
inherited leukodystrophies are diseases of myelin including abnormal myelin development , hypomyelination , or degeneration of myelin .
we report a 6-year old female who presented with absence s... |
bureaucracy has consequences . in 2004 , time magazine attributed the nearly 400,000 european
researchers in the us to two key factors funds and bureaucracy .
although many researchers were attracted by money and opportunity , many more were
escaping constraints that faced them at home .
the european union ( e... | over the past 15 years , the european union ( eu ) has spent around 80 billion on science
research via framework programmes ( fp5 , fp6 and fp7 ) . in 2014 ,
a new programme , horizon
2020 , will likely invest another 70 billion over 6 years .
health research has been a
major part : between 12% and 17% was ... |
although substantial progress has been made in the awareness , prevention , and treatment of cardiovascular disease in women in the united states ( usa ) over the past 10 years , women 's lifetime risk of cardiovascular disease is high .
adverse trends in cardiovascular disease risk factors are a growing concern , pa... | background .
this study investigated the associations of fitness and fatness with metabolic syndrome in rural women , part of a recognized us health disparities group . methods .
fitness , percentage body fat , bmi , and metabolic syndrome criteria were assessed at baseline in 289 rural women with prehypertension ,... |
os objetivos do presente estudo foram avaliar as concentraes de flor ( f ) em leites integrais , desnatados e achocolatados disponveis comercialmente no brasil e estimar a ingesto diria de f a partir destas fontes .
as concentraes de f foram determinadas em 23 marcas de leite , aps difuso facilitada por hmds , usando... | objectives : the aims of the present study were to evaluate the fluoride ( f ) concentrations in whole , defatted and chocolate milks commercially available in brazil and to estimate the daily f intake from these sources.material and methods : f concentrations were determined for 23 brands of milks , after hmds - facil... |
the mode of action of many drugs in clinical use for the treatment of cancer , genetic disorders , and viral diseases is believed to be based on their binding to nucleic acids and subsequent modification of the genetic material [ 1 , 2 ] .
the discovery of the double helical structure of deoxyribonucleic acid ( dna )... | bioactive alkaloids occupy an important position in applied chemistry and play an indispensable role in medicinal chemistry . amongst them , isoquinoline alkaloids like berberine , palmatine and coralyne of protoberberine group , sanguinarine of the benzophenanthridine group , and their derivatives represent an importa... |
within hcfa 's office of the actuary , the office of national health statistics ( onhs ) is charged with the responsibility for maintaining the national health accounts ( nha ) .
these accounts form the structure for maintaining health care expenditure information for the united states . in response to a request by t... | as the first step in a pioneering effort by the health care financing administration ( hcfa ) to measure interstate border crossing for services used by both medicare and non - medicare beneficiaries , the authors study the spending behavior of medicare beneficiaries for 10 medicare - covered services . based on inters... |
bereavement is a common term used to describe having lost someone important or significant through death .
this intense emotion or distress following bereavement is referred to as grief , or the emotional reaction to bereavement .
grief is complex , and incorporates multiple symptoms such as anger and sadness , and... | to date there have been no studies examining complicated grief ( cg ) in aboriginal populations .
although this research gap exists , it can be hypothesized that aboriginal populations may be at increased risk for cg , given a variety of factors , including increased rates of all - cause mortality and death by suicid... |
image - guided tumour ablation is one of the exciting and promising developments in radiology .
radiofrequency ablation ( rfa ) is used in many centres to treat hepato - cellular carcinoma ( hcc ) and hepatic metastases as a complementary method to liver resection .
there is interest in using magnetic resonance ( m... | abstractthere is a sustained interest in using magnetic resonance ( mr ) thermometry to monitor the radiofrequency ablation of liver tumours as a means of visualizing the progress of the thermal coagulation and deciding the optimal end - point . despite numerous technical challenges ,
important progress has been made... |
blood flow rate ( bfr ) < 300 ml / min often is used to define hemodialysis catheter dysfunction , including in the national kidney foundation 's ( nkf ) kidney disease outcomes quality initiative ( kdoqi ) vascular access guidelines [ 1 , 2 ] , and in many research studies . causes of catheter dysfunction include mec... | practice guidelines define hemodialysis catheter dysfunction as blood flow rate ( bfr ) < 300 ml / min .
we conducted a study using data from davita and the united states renal data system to evaluate the impact of catheter dysfunction on dialysis and other medical services .
patients were included if they had 8 c... |
a seventy year - old woman presenting gradual evolution pruritus gets worse recently . at clinical examination ,
both labia were observed as white plates , dispersed , irregular borders and sanded surface , suggestive of high - grade intraepithelial vulvar neoplasia .
she was undergone to a vulvar polyp that rev... | neuroendocrine tumours are rare in the gynaecologic tract , comprising approximately 2% of all gynaecological tumours .
they have an aggressive behaviour and are a diagnostic and clinical challenge , due to their rarity and the lack of standardized therapeutic approaches .
there are a few case reports .
it is def... |
priapism constitutes a urologic emergency in which persistent erection occurs that is not accompanied by sexual desire , usually lasting for more than 6 h and typically involving only the corpora cavernosa .
priapism has been associated with many known different disease states and some situations that constitute risk... | a 15-year - old boy presented with priapism of 46 h duration .
there was no known cause of priapism detected in him . during evaluation , biopsy of the lymph node and bone marrow aspiration detected patient
to be having niemann pick disease .
he was managed with cavernous aspiration , saline irrigation , and int... |
the duodenum is a common location for intestinal obstruction in the newborn requiring surgical intervention .
intrinsic obstruction ranges from complete atresia with a gap to membranous web and to stenosis .
in contrast to small intestinal atresia , ontogeny is thought to be secondary to failure of luminal recanali... | background .
a common site for neonatal intestinal obstruction is the duodenum .
delayed establishment of enteral nutritional autonomy continues to challenge surgeons and , since early institution of nutritional support is critical in postoperative newborns , identification of patients likely to require alternative... |
primary intraosseous odontogenic squamous cell carcinoma ( pioscc ) is a rare and malignant tumor .
the etiology seems to be related to the malignant degeneration of embryological remains . in this line ,
epithelial rests of malassez , dental lamina and epithelium of the dental follicle represent potential suspects... | primary intraosseous odontogenic squamous cell carcinoma ( pioscc ) is a rare tumor .
the incidence is low , and approximately 200 cases are reported in literature .
the etiology is associated with the malignant degeneration of embryological remains .
differential diagnosis includes alveolar carcinomas , jaw meta... |
cerebral microbleeds ( cmbs ) are defined as small perivascular hemosiderin deposits . with the widespread use of magnetic resonance imaging ( mri ) , cmbs are more commonly detected . in studies using sensitive mri technique ,
the prevalence of cmbs is as high as 11.1%23.5% in community - dwelling elderly people . p... | background : with the widespread use of magnetic resonance imaging ( mri ) , cerebral microbleeds ( cmbs ) are commonly detected .
ethnicity seems to play a role in the prevalence of cmb , with higher prevalence in participants from asian origin .
the purpose of the study is to look for the prevalence of cmbs and a... |
dermatitis herpetiformis ( dh ) is one of the subepidermal autoimmune bullous diseases ( abd ) characterized by skin and intestinal lesions .
diagnosis of dh is established based on the results of direct immunofluorescence test ( dif ) and the presence of circulating iga antibodies directed against endomysium and/or ... | dermatitis herpetiformis ( dh ) and bullous pemphigoid ( bp ) are skin diseases associated with eosinophilic and neutrophilic infiltrations . although chemokines are critical for the selective accumulation and activation of various leukocyte subsets in the inflammatory process , there are few findings concerning inflam... |
preservation of hard tissues close to the living state is essential for understanding of cellular and subcellular structures and functions .
the cutting of thin sections by ordinary methods is impossible in the case of tissues such as teeth , bone , teratomas containing bony tissue , lesions that have become partly c... | introduction : the microwave oven has been used quite often for tissue processing , but there are very few studies describing its use in decalcification of bone or teeth . in this study
we have attempted to decalcify bone and teeth using a microwave oven and compare the process and results with conventional decalcifi... |
the ttm trial randomized 950 adult comatose patients resuscitated after out - of - hospital cardiac arrest of presumed cardiac cause from november 2010 to january 2013 .
the trial protocol was approved by the ethics committees in the participating countries and registered at clinicaltrials.gov ( nct01020916 ) .
sed... | objective : to identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine eeg and standardized interpretation according to the terminology proposed by the american clinical neurophysiology society.methods:in this cohort study , 4 eeg specialists , blinded to outcome , evalu... |
daily lifestyle habits , such as physical activity , smoking , alcohol drinking and dietary intake , are associated with the risk of developing impaired glucose tolerance ( igt ) or diabetes mellitus ( dm ) .
recently , sleep duration , one of the daily lifestyle habits , has gained attention with regard to its assoc... | abstractaims / introduction : to examine the crosssectional relationship between sleep duration and impaired glucose tolerance ( igt ) , including diabetes mellitus ( dm ) , we analyzed a largescale healthy workers database in japan.materials and methods : we examined the baseline database of 4143 participants ( 34... |
the online version of this article ( doi:10.1007/s12471 - 014 - 0624-y ) contains supplementary material , which is available to authorized users .
pulmonary vein isolation ( pvi ) has become an important treatment modality for atrial fibrillation ( af ) [ 1 , 2 ] although af recurrences can occur .
several pvi tec... | introductionthe endoscopic laser balloon ablation system ( eas ) is a relatively novel technique to perform pulmonary vein isolation ( pvi ) in the treatment of atrial fibrillation ( af ) .
the present study aimed to report the results of the first 50 patients treated in the netherlands with the eas in terms of proce... |
the archetypal animal mitochondrial dna ( mtdna ) is a 15- to 20-kb circular molecule ( boore 1999 ) .
medusozoan cnidarians ( jellyfish and hydroids ) are among the few metazoans whose mtdnas depart significantly from this traditional architecture .
staurozoans , scyphozoans , and most hydrozoans have linear mon... | animal mitochondrial dnas ( mtdnas ) are typically single circular chromosomes , with the exception of those from medusozoan cnidarians ( jellyfish and hydroids ) , which are linear and sometimes fragmented .
most medusozoans have linear monomeric or linear bipartite mitochondrial genomes , but preliminary data have ... |
denvdengue virusesdc - signdendritic cell - specific intercellular adhesion molecule-3-grabbing non - integrinhsp70heat shock protein 70hsp90heat shock protein 90ssrna+single - stranded positive - sense rna virusesmrcamore recent common ancestorutruntranslated regioneenvelope proteinmmembrane proteinns1non - structural... | dengue is a major threat for public health in tropical and subtropical countries around the world . in the absence of a licensed vaccine and effective antiviral therapies , control measures
have been based on education activities and vector elimination .
current efforts for developing a vaccine are both promising a... |
obesity and overweight have both been described as anomalous accumulation of excessive body fat which may be harmful to health .
there is no single cause to explain all cases of obesity and overweight but most studies implicate imbalance in the amounts of calories consumed and those expended .
the disruption of the... | the aim was to determine the prevalence of obesity and overweight among students in the kumasi metropolis . in a descriptive cross - sectional study ,
500 students aged 10 to 20 years were examined from two junior high schools selected by multistage sampling technique and three randomly selected senior high schools .... |
malaria is a major public health problem in tropical and subtropical countries including india and its dynamics vary from place to place . among all anopheline vectors , anopheles culicifacies ( diptera : culicidae ) is a principal malaria vector in rural , periurban and tribal settings ( mishra et al .
culicifacies ... | background : anopheles culicifacies is an important vector of malaria in southeast asia , contributing to almost 70% of malaria cases in india .
it exists as a complex of five morphologically indistinguishable species a , b , c , d and e with varied geographical distribution patterns . in india
, 8% of the total po... |
cancer is a leading cause of death worldwide and accounts for 7.6 million deaths every year .
the first and second most common causes of cancer death in the world are lung cancer ( 1.37 million deaths , annually ) and gastric cancer ( 736000 deaths , annually ) , respectively ( 1 ) . about 70% of all cancer deaths ha... | background : the incidence rate of gastric cancer in western countries has shown a remarkable decline in the recent years while it is still the most common cancer among males in iran .
the proto - oncogene myc , located at 8q24.1 , regulates almost 15% of human genes and is activated in 20% of all tumors .
the ampl... |
november 2014 , a total of 20 suspected cases of illness were clinically diagnosed as dengue in wenzhou ( 5 cases ) and wuhan ( 15 cases ) .
the cohort comprised 14 male and 6 female patients 761 ( median 31 ) years of age . of the patients from wuhan ,
11 had recently traveled to guangdong province ; 3 had recentl... | in 2014 , 20 dengue cases were reported in the cities of wenzhou ( 5 cases ) and wuhan ( 15 cases ) , china , where dengue has rarely been reported .
dengue virus 1 was detected in 4 patients .
although most of these cases were likely imported , epidemiologic analysis provided evidence for autochthonous transmissio... |
overweight and obesity are serious health problems [ 1 , 2 ] which have increased during the past decades [ 1 , 3 ] in the us , in other
they tend to cause health damages with potentially immense expenditures [ 5 , 6 ] .
an appropriate definition of overweight and obesity is essential to the public health community... | validation of body - mass relationships requires a careful statistical analysis of data of normal weight individuals .
bmi
( ratio between body mass and square of body height ) and bsi values ( ratio between mass and cube of body height ) have been calculated
for 99 persons with ages between 1 day and 76 years . ... |
esophagorespiratory fistula ( erf ) is an uncommon condition , despite of the anatomical proximity of these structures .
malignancy of esophagus , lung , or mediastinum is recognized as the most common cause .
causes of erf development include direct tumor invasion and subsequent perforation or after radiation , la... | the most common cause of esophagorespiratory fistulas ( erfs ) is associated with malignancy .
the use of self - expandable metal stents is effective for the treatment of malignant erfs , but benign erf is rare , which is why its optimal treatment is not defined yet . there have been few reports describing benign eso... |
sjgren 's syndrome is a slowly progressing autoimmune disease characterized by lymphocytic infiltration of the exocrine glands , mainly the lacrimal and salivary glands , resulting in impaired secretory function .
simultaneously , systemic features of cutaneous , respiratory , renal , hepatic , neurologic , and vascu... | primary sjgren 's syndrome ( pss ) is a chronic autoimmune disease characterized by a progressive lymphocytic infiltration of the exocrine glands with varying degrees of systemic involvement .
overt or latent renal tubular acidosis ( rta ) , caused by tubulointerstitial nephropathy , is a common extraglandular manife... |
a 59-year - old
female receiving alemtuzumab for chronic lymphocytic leukemia was admitted to a
local hospital near her home in eastern kentucky in october 2007 for altered
mental status of two weeks duration .
admission laboratory values included a white blood count of 5 900/mm ,
hemoglobin of 10.4 g / dl ... | strongyloides stercoralis affects over 100 million people worldwide .
those people most susceptible to infection are those with an immunocompromising condition , such as cancer or human immunodeficiency virus ( hiv ) .
local disease may spread throughout the body of the host , causing a condition termed disseminate... |
the study was conducted at specialized deaddiction services provided at a tertiary care hospital in south india .
the participants for the study were recruited from an inpatient setting . to be included in the study ,
the patients were required to be older than 18 years of age , fulfilling the diagnostic criteria f... | background : work - related problems are a serious concern among persons with substance use but due to lack of a standardized tool to measure it ; these problems are neither systematically assessed nor appropriately addressed .
most existing measures of work performance cater to the needs of the workplace rather than... |
a cyst is a pathological epithelial cell - lined cavity that is filled with fluid or soft material .
they are frequently found as intra - bony lesions of the jaw , which can expand so drastically that sometimes the facial appearance can change .
although removal of the cyst is necessary in these cases , enucleation... | objectivesthe aim of this study was to verify the clinical effectiveness of decompression in decreasing the size of a cyst .
in addition to the different types of cysts , we tried to reveal what effect host factors , such as the initial size of the lesion and the age of the patient , have on the velocity of cyst shri... |
fracture of dual columns of the acetabulum is the most complicated type of acetabular fracture .
posterior - anterior column fixation is considered to be important for joint stability and early mobilization after surgery .
ochs et al . investigated screw placement into the anterior column with ct analysis for 260... | backgroundthe aim of this study was to provide valid data for a plate - screw fixation model for fractured posterior - anterior columns of the acetabulum.material/methodsnineteen cadaveric bony hemi - pelvis specimens were obtained and 50 healthy adults were enrolled . the modified stoppa approach and computed tomograp... |
on march 6 , 2015 , we conducted an aerial survey covering a 24-km radius around the pope county facility and identified 100 resident mallards ( anas platyrhynchos ) and 21 trumpeter swans ( cygnus buccinator ) . during march 912 , 2015 , we collected 148 representative waterfowl fecal samples , pooled in groups of up ... | in 2015 , a major outbreak of highly pathogenic avian influenza virus ( hpaiv ) infection devastated poultry facilities in minnesota , usa .
to understand the potential role of wild birds , we tested 3,139 waterfowl fecal samples and 104 sick and dead birds during march 9june 4 , 2015 .
hpaiv was isolated from a co... |
type 2 diabetes mellitus ( t2 dm ) has continued to increase worldwide , reaching a figure of about 370 million in 2011 , with 4.6 million associated deaths per year.1 the standard therapy for this epidemic disease includes diet , exercise , use of oral hypoglycemic drugs , and/or subcutaneous insulin injections.2,3 se... | backgroundberberine is an isoquinoline alkaloid widely used to improve the glucidic and lipidic profiles of patients with hypercholesterolemia , metabolic syndrome , and type 2 diabetes .
the limitation of berberine seems to be its poor oral bioavailability , which is affected by the presence , in enterocytes , of p ... |
drug delivery strategies commonly use
endocytosis to access the
cell interior ; however , the potential for disease to affect endocytic
behavior remains relatively unexplored , hindering the design of robust
therapeutics .
endocytosis encompasses several energy - dependent and
highly regulated processes thr... | drugs
often use endocytosis to achieve intracellular delivery ,
either by passive uptake from the extracellular fluid or by active
targeting of cell surface features such as endocytic receptors .
an
example is enzyme replacement therapy , a clinically practiced treatment
for several lysosomal storage diseas... |
the elderly are at risk for nutritional disorders and malnutrition , including undernutrition and nutrient deficiencies and imbalances .
several age - related physical , clinical , economic , and social factors can compromise nutritional status ; furthermore , changes in the body composition of elderly people and sed... | introduction poor diet habits and inadequate intake of nutrients are a concern in the elderly .
nutritional education with guidance may improve the results of the treatment of vertigo .
objective evaluate the presence of benign paroxysmal positional vertigo ( bppv ) associated with feeding habits .
methods cro... |
injuries to the extrahepatic biliary system in blunt abdominal trauma are uncommon [ 17 ] .
extrahepatic hepatic ductal injuries ( ehdis ) occur even less frequently [ 18 ] . because of their rarity and the frequently insidious onset of symptoms ,
ehdis are commonly missed during the initial trauma evaluation , and... | extrahepatic hepatic ductal injuries ( ehdis ) due to blunt abdominal trauma are rare . given the rarity of these injuries and the insidious onset of symptoms , ehdi are commonly missed during the initial trauma evaluation , making their diagnosis difficult and frequently delayed .
diagnostic modalities useful in the... |
diabetes mellitus ( dm ) is a chronic progressive metabolic disorder due to absolute ( type 1 ) or relative ( type 2 ) deficiency of insulin hormone . worldwide ,
366 million people were estimated to have diabetes mellitus in the year 2011 , and numbers are predicted to double by 2030 [ 24 ] .
dm has caused approxi... | the aim of this study was to explore predictors of health related quality of life ( hrqol ) among men and women with type 2 diabetes .
this cross - sectional descriptive study consisted of a random sample of 300 adults with type 2 diabetes in a selected public hospital .
euro - qol and revised summary of diabetes s... |
all subjects were evaluated during a 2010 family forum in chicago , as part of our monogenic diabetes registry ( http://monogenicdiabetes.uchicago.edu ) ( 11 ) . all parents provided informed written consent as approved by the university of chicago institutional review board .
the beery - buktenica developmental test... | objectiveto assess performance on an age - standardized neuromotor coordination task among sulfonylurea - treated kcnj11-related neonatal diabetic patients.research design and methodsnineteen children carrying kcnj11 mutations associated with isolated diabetes ( r201h ; n = 8) , diabetes with neurodevelopmental impairm... |
diagnosis of fronto - temporal dementia ( ftd ) requires beside brain - imagining a careful evaluation of genetic and neuropathological , cognitive processes disorders , and behaviour problems .
the complexity of the symptoms observed after frontal lobe damage creates the necessity for a very careful neuropsycholog... | summarybackgroundthe aim of the paper is the differential diagnosis of various types of fronto - temporal dementia ( ftd ) , with the focus on its behavioural variant ( bvftd).material / methodmaterial and method .
screening was done in order to assess the depth of dementia with the short version of mmse , while eval... |
arterial baroreflex is the main mechanism for the regulation of the cardiovascular system , and sinoaortic denervation ( sad ) is a widely used tool to study its function.1 it is well established that chronic sad increases blood pressure variability ( bpv ) without increasing mean blood pressure.2 previous studies have... | objective : the aim of this study was to evaluate the role of angiotensin i , ii and 17 on left ventricular hypertrophy of wistar and spontaneously hypertensive rats submitted to sinoaortic denervation.methods:ten weeks after sinoaortic denervation , hemodynamic and morphofunctional parameters were analyzed , and the l... |
increased expression of genes necessary for detecting and repairing dna damage can result when cells are exposed to certain genotoxic compounds [ 13 ] .
these same treatments can also induce differential expression of genes in the ubiquitin- ( ub- ) mediated proteolytic pathway [ 4 , 5 ] , suggesting interplay betwee... | regulation of dna repair can be achieved through ubiquitin - mediated degradation of transiently induced proteins . in saccharomyces cerevisiae , rad4 is involved in damage recognition during nucleotide excision repair ( ner ) and , in conjunction with rad23 , recruits other proteins to the site of damage .
we identi... |
a ruptured infected aortic aneurysm with staphylococcal sepsis is rare yet potentially life - threatening condition .
although ruptured infected aneurysm is usually treated surgically , it has still high operative mortality and morbidity , especially high surgical risk . despite recent improvement in endovascular tre... | the generally accepted treatment for infected aortic aneurysms involves open surgical resection and debridement , with in situ or extra - anatomical bypass .
occasionally , endovascular management can be substituted for the standard operation dependent on the patient 's condition .
we report the case of an 81-year ... |
vesicoureteral reflux ( vur ) in children has been referred as the prostate cancer of pediatric urology , as the 2 conditions share many features such as the high prevalence rates in their respective populations , the recent decline in utilization of diagnostic studies for these conditions , the historically high uti... | the da vinci robotic system has improved surgeon dexterity , ergonomics , and visualization to allow for a minimally invasive option for complex reconstructive procedures in children . over the past decade , robot - assisted laparoscopic ureteral reimplantation ( ralur ) has become a viable minimally invasive surgical ... |
clinical manifestations of toxicity are similar to those of cocaine and include sudden death due to cardiac arrhythmia , stroke , seizures , psychosis , and rhabdomyolysis .
neuropathologic alterations of amphetamine abuse include cerebral infarcts and hemorrhage , often caused by emboli associated with cardiac arrhy... | we report the case of a 31-year - old woman , admitted to the hospital for chest pain , dying a few days later from septic multiorgan failure , and showing at autopsy foci of acute demyelination in the occipital lobe .
gas chromatography / mass spectrometry analysis revealed the presence of amphetamine in the demyeli... |
biobanks collect and store human and non - human biological material for diagnostic and research purposes .
these biobanks keep sensitive data and biological samples also for long periods of time , and such data and samples can be used for research even many years after they have been deposited .
therefore , a well... | backgroundthe center for transfusion medicine , cell therapy and cryobiology , milan , northern italy , is the headquarter of the poli - mi biobank . it co - ordinates the biobank activities of the fondazione ca granda ospedale maggiore policlinico of milan .
such activities require specific safeguarding of donors ri... |
all the authors provided substantial contributions to conception and design , acquisition of data , or analysis and interpretation of data ; they assisted in drafting the article or revising it critically for important intellectual content ; and they provided final approval of the version to be published .
extramural... | background and objective the clinical note documents the clinician 's information collection , problem assessment , clinical management , and its used for administrative purposes .
electronic health records ( ehrs ) are being implemented in clinical practices throughout the usa yet it is not known whether they improv... |
the different forms of contamination come from different sources and are dealt with in different ways .
contamination can occur at the source , between source and storage points or in storage tanks .
defective joints , syphonage , rusted pipelines , and crossing over of sewage pipelines are other causes of contamin... | this study is designed to determine the contamination degree of hospital water supplies with pseudomonas aeruginosa , legionella pneumophila , and e. coli in gilan , iran .
samples were collected directly into sterile containers and concentrated by centrifuge .
half part of any sample transferred to yeast extract b... |
the selective modulation of eukaryotic
gene expression by small
molecules may have important implications in the field of chemical
biology and human medicine .
pyrrole - imidazole polyamides are a class
of synthetic ligands that can be programmed to bind the minor groove
of specific dna sequences .
antipa... | cyclic py - im polyamides containing two gaba turn units
exhibit
enhanced dna binding affinity , but extensive studies of their biological
properties have been hindered due to synthetic inaccessibility .
a
facile modular approach toward cyclic polyamides has been developed
via microwave - assisted solid - p... |
an osteochondroma or exostosis is a benign bone tumour consisting of a bony outgrowth covered by a cartilage cap that occurs commonly in the metaphysis of long bones ( distal femur , proximal tibia , proximal humerus ) and pelvis .
osteochondromas are rarely localized in the foot and ankle , except in cases of multip... | introductionan osteochondroma or exostosis is a benign bone tumour consisting of a bony outgrowth covered by a cartilage cap that occurs commonly in the metaphysis of long bones , mainly the distal femur , proximal tibia and proximal humerus.presentation of casewe describe an unusual case of a distal tibia osteochondro... |
intraductal papillomas are relatively common benign breast lesions , and represent about 5% of proliferative benign breast lesions
1 . they may clinically present either as mammographically detected or palpable breast masses , with or without nipple discharge .
giant intraductal breast papillomas are uncommon and t... | key clinical messagethe differential diagnosis of a large breast mass in a post - menopausal woman can include both benign and malignant etiologies . although rare , diagnosis of giant intraductal papilloma must be considered in the differential .
furthermore , although benign , papillomas presenting as a large breas... |
immortalized human nscs using a retroviral vector carrying v - myc and vascular endothelial growth factor ( hb1.f3.vegf ) were maintained at a density of 1 10 cells/100-mm dish ( sarstedt , sparks , nv ) in dulbecco 's modified eagle 's medium with high glucose ( dmem , hyclone , logan , ut ) containing 10% fetal bovi... | objectiveto access the feasibility of clinically available 3 t mri to detect the migration of labeled neural stem cells ( nscs ) in intracerebral hemorrhage ( ich ) in a rat model.materials and methodsthe ethics committee of our institution approved this study .
ich was induced by the injection of collagenase type iv... |
alpha spectrometry is the most widely used method for the determination of plutonium isotopes in environmental samples .
however , this method does not permit the determination of beta - emitting pu , a radionuclide abundant in the environment .
the best way to determine pu in an environmental sample is by liquid s... | a simple and rapid procedure for the determination of plutonium isotopes in the environment is presented .
the procedure combines alpha spectrometry , solvent extraction and liquid scintillation measurements to ensure that both alpha- and beta - emitting isotopes are determined . of five tested extractants , bis-(2-e... |
the groups of suprahyoid muscles include four muscles : the digastric , the geniohyoid , stylohyoid and mylohyoid .
the bellies of the digastric are joined together by an intermediate tendon that passes through a fibrous sling that is attached to the body of the hyoid bone .
these muscle groups anchor the hyoid bon... | the digastric muscle is composed by two muscle bellies : an anterior and a posterior , joined by an intermediate tendon . this muscle is situated in the anterior region of the neck .
the region between the hyoid bone and the mandible is divided by an anterior belly into two triangles : the submandibular situated late... |
staphylococcus aureus is a main source of hospital - acquired infections causing pneumonia , endocarditis , osteomyelitis , soft - tissue , and skin infections .
s. aureus also causes serious nail infections ( paronychia ) and is a common cause of food poisoning due to the production of enterotoxin .
a main problem... | the regulation of rna decay is now widely recognized as having a central role in bacterial adaption to environmental stress . here
we present an overview on the diversity of ribonucleases ( rnases ) and their impact at the posttranscriptional level in the human pathogen staphylococcus aureus .
rnases in prokaryotes... |
partial gonadal dysgenesis ( pgd ) , one of the 46,xy disorders of sex development ( dsd ) , is a rare disorder characterized by sex ambiguity due to variable degrees of testicular dysgenesis in individuals without a syndromic picture who have a normal male karyotype .
the histology of dysgenetic testes may vary from... | background / aims .
studies on 46,xy partial gonadal dysgenesis ( pgd ) have focused on molecular , gonadal , genital , and hormone features ; little is known about follow - up .
our aim was to analyze long - term outcomes of pgd .
methods .
retrospective longitudinal study conducted at a reference service in b... |
the ingestion of instruments or materials used in various dental procedures may occur accidentally in dentistry .
foreign bodies vary in size and shape and range from burs , posts , root pieces , teeth , orthodontic brackets , endodontic instruments ( files , broaches ) , impression materials , implant components , a... | one of the complications during a routine dental implant placement is accidental ingestion of the implant instruments , which can happen when proper precautions are not taken .
appropriate radiographs should be taken to locate the correct position of foreign body ; usually the foreign body passes asymptomatically fro... |
clinical studies of the efficacy of fingolimod ( fty ) investigated fty as first line medication in relapsing - remitted multiple sclerosis ( rrms ) in comparison to placebo or once weekly intramuscular interferon--1a showing its superiority regarding relapse rate , progression of disability and end points of mri .... | although fingolimod is registered as a second - line drug in relapsing - remittend multiple sclerosis ( rrms ) in europe there are no clinical studies available comparing fingolimod ( fty ) and natalizumab ( n ) .
this observational cohort - study used health data routinely collected in outpatient neurology practices... |
spinal epidural angiolipomas are uncommon , benign tumors accounting for 0.041.2% of spinal axis tumors and 23% of extradural spinal tumors .
all angiolipomas show iso- or hyperintensity on t1-weighted images and hyperintensity on t2-weighted images of magnetic resonance imaging ( mri ) and most lesions enhance with ... | spinal epidural angiolipomas are rare , benign tumors composed of mature lipocytes admixed with abnormal blood vessels
. only 128 cases of spinal epidural angiolipomas have been reported in literature till now .
spinal angiolipomas are predominantly located in the mid - thoracic region .
we report a case of dorsa... |
advances in three - dimensional imaging resulted in a better understanding of the craniofacial structures .
one of the modern techniques , cone beam computed tomography ( cbct ) , which was invented for angiography in 1982 , was then used for maxillofacial imaging .
in contrast to the common cephalometric radiograp... | background : bone density measurement in a radiographic view is a valuable method for evaluating the density of bone quality before performing some dental procedures such as , dental implant placements . it seems that cone - beam computed tomography ( cbct ) can be used as a diagnostic tool for evaluating the density o... |
neuroendocrine tumors ( nets ) of the pancreas are rare , comprising 12% of all pancreatic malignancies .
the vast majority of these are primary pancreatic malignancies , as metastases to the pancreas are rare , and metastases of neuroendocrine tumors from other primary sources to the pancreas are even rarer .
pulm... | introductionprimary pancreatic neuroendocrine tumors are a well - established disease entity , however , neuroendocrine metastases to the pancreas from other sites have been scarcely documented .
specifically , pancreatic metastases from a pulmonary carcinoid tumor have only previously been described in a single case... |
obesity , an excessive accumulation of fat in an individual , is an important public health issue and contributes to serious health problems and extensive economic costs worldwide .
a common measure of adult obesity is body mass index , defined as a person 's weight ( in kilograms ) divided by the square of his or he... | psychological distress and deficits in executive functioning are likely to be important barriers to effective weight loss maintenance .
the purpose of this paper is twofold .
first , in the light of recent evidence in the fields of neuropsychology and obesity , particularly on the deficits in the executive function... |
the term comorbidity was introduced in 1970 by feinstein , a doctor of internal medicine and epidemiologist who studied cooccurrence of diseases among persons with diabetes .
any distinct clinical entity that has existed or that may occur during the course of a patient who has the index disease under study , in whic... | type 2 diabetes and depression are regarded as comorbid conditions , and three possible directions of the association between the diseases can underlie this observation of comorbidity .
first , common etiology can increase a person 's risk of both diseases ; second , persons with type 2 diabetes have increased preval... |
nearly all types of malignant cells and many types of diseased tissue cells demonstrate alterations in their glycosylation patterns when compared to their normal counterparts .
alterations in glycosyltransferases expression , sugar nucleotide donors , and disruption of the golgi contribute to the development of disea... | background .
tumor cells show alterations in their glycosylation patterns when compared to normal cells .
lectins can be used to evaluate these glycocode changes .
chemiluminescence assay is an effective technique for quantitative analysis of proteins , nucleic acids , and carbohydrates due to its high sensitivit... |
access to public ltss programs varies across states and across disability and age groups , resulting in inequities based on where one lives , whether one s disability is lifelong or acquired , and which functions it affects .
a complex , fragmented system is at the root of the problem , along with the institutional ... | in response to a new federal initiative to improve the u.s . long - term services and supports ( ltss )
system , this commentary discusses an array of policies and practices that could potentially improve ltss provision by shifting from institutional to community - based services , increasing equity across population... |
to evaluate the role of high resolution ultrasonography ( us ) and endoscopic ultrasonography ( eus)-elastography in predicting malignant lymphadenopathy .
this prospective study included 88 patients who underwent eus or us examination of different groups of lymph nodes ( lns ) .
the classification as benign or mal... | objective : to evaluate the role of high resolution ultrasonography ( us ) and endoscopic ultrasonography ( eus)-elastography in predicting malignant lymphadenopathy.methods:this prospective study included 88 patients who underwent eus or us examination of different groups of lymph nodes ( lns ) .
the classification ... |
it classically occurs in the second decade of life , has its onset during puberty , and affects both sex and all ethnicities .
the estimated prevalence in the general population is 54 per 100,000 . using a combination of four indices , ie ,
central k ( descriptive of central steepening ) , the i - s value ( inferio... | this case report describes a 17-year - old boy with sensory strabismus due to keratoconus and an ipsilateral nodular lesion of the bulbar conjunctiva . the aligned eye was the right eye and keratoconus in this eye was of late onset .
vision in the left eye was poor and keratoconus was advanced in this eye . due to th... |
in the current issue of critical care , venkatesh and colleagues present a novel study on adiponectin in critical illness .
this article , along with the concept of adipose tissue and adipocytokines being involved in the mechanisms of critical illness , requires some commentary .
historically , adipose tissue was t... | historically , adipose tissue was thought to be a passive tissue that stores energy and protects the body from temperature and injury .
in contrast to this concept , it is now evident that adipose tissue is an active endocrine organ secreting many kinds of adipocytokines , including adiponectin . presumably , adipose... |
it has now been 20 years since the first reports appeared demonstrating that interleukin-2 is required to prevent the development of systemic autoimmune disease .
subsequent studies by sakaguchi and colleagues identified cd25 , the interleukin-2 receptor chain ( il2r ) , as one of the first useful markers for the id... | interleukin-2 and its downstream target stat5 have effects on many aspects of immune function .
this has been perhaps best documented in regulatory t cells . in this review
we summarize the initial findings supporting a role for il2 and stat5 in regulatory t cell development and outline more recent studies describi... |
the light microscopic study was performed on 40 human horizontal rectus muscles obtained from 3 normal subjects and 34 patients with oculomotor disorders .
six control horizontal rectus muscles were obtained from the right globe of 3 multiorgan donors ( 2 muscles from each ) a few hours after postmortem in conformity... | purposeto analyze innervated myotendinous cylinders ( imcs ) in the extraocular muscles ( eoms ) of normal subjects and strabismic patients.methodsthe rectus muscles of 37 subjects were analyzed .
distal myotendinous specimens were obtained from 3 normal subjects , 20 patients with acquired strabismus , 11 with infan... |
incomplete spinal cord injury ( sci ) is characterized by partial functional loss , with
varying degrees of voluntary motor and sensory functions remaining in the three segments
below the injury at a neurological level1 , 2 .
the majority of patients with incomplete
sci showed impaired upper extremity function ... | [ purpose ] in this study , we examined effects of modified constraint - induced movement
therapy ( m - cimt ) and functional bimanual training , when applied to a patient with
incomplete spinal cord injury , on upper extremity function and daily activities .
[ subject
and methods ] one patient , diagnosed with... |
the classic scenario for crc progression is the lymphatic , hematogenous ( to the liver , the lungs , etc ) and peritoneal metastases .
there have been standard treatment strategies for the first two forms of metastases , but a unified treatment guideline is yet to be formulated for the third form of metastasis , whi... | backgroundadvanced colorectal cancer ( crc ) is prone to developing peritoneal carcinomatosis ( pc ) .
this case - control study was to compare the efficacy and safety of cytoreductive surgery ( crs ) versus crs plus hyperthermic intraperitoneal chemotherapy ( hipec ) in chinese patients with crc pc.methodsthe 62 con... |
traumatic brain injury ( tbi ) is known to cause several secondary effects , which lead to peripheral organs dysfunction .
the close relationship between brain injury and subsequent intestinal mucosal injury has been recognized [ 1 , 2 ] .
this pathologic course may not only influence the intestinal mucosa itself b... | traumatic brain injury ( tbi ) can induce intestinal inflammatory response and mucosal injury .
antioxidant transcription factor nuclear factor erythroid 2-related factor 2 ( nrf2 ) has been shown in our previous studies to prevent oxidative stress and inflammatory response in gut after tbi .
the objective of this ... |
microencapsulation has gained importance in the fields of cell and tissue engineering , as well as in the development of drug formulations and oral delivery systems .
the term microencapsulation , in this work , encompasses the terms microcapsules , microparticles , microspheres , and microemulsions .
generally , t... | microencapsulation is a technology that has shown significant promise in biotherapeutics , and other applications .
it has been proven useful in the immobilization of drugs , live mammalian and bacterial cells and other cells , and other biopharmaceutics molecules , as it can provide material structuration , protecti... |
cutaneous leishmaniasis ( cl ) is a serious and increasing health problem worldwide and is endemic in nearly 90 countries , including iran ( 1 ) . in iran , the disease is mainly caused by leishmania major and l. tropica , although leishmania infantum has been infrequently isolated from patients with cutaneous leishman... | background : cutaneous leishmaniasis ( cl ) is a parasitic disease with a relatively wide distribution in different areas of the world , including iran .
the parasite is mainly diagnosed microscopically , but serological approaches might be useful for diagnosis as well .
this study aimed to assess the efficacy of a... |
every year , more than one million cases of scorpion stings are reported in the world ( 1 ) .
most of these cases are reported in mexico , tunisia , and brazil ( 2 ) .
the hemiscorpius genus of scorpions is distributed throughout asia ( iran , iraq , oman , pakistan , saudi arabia , yemen , and the united arab emir... | scorpion stings are significant causes of death in the western and southern regions of iran . to date
, reports have indicated that the h. lepturus species is the main cause of mortality due to scorpion stings .
one of the species that belongs to this genus is hemiscorpius acanthocercus ( h. acanthocercus ) .
thi... |
the study population consisted of overweight ( bmi 25 kg / m ) adults without diabetes who were abdominally obese ( waist circumference > 40 inches in males and > 35 inches in females ) and who lived in eight rural underserved communities in southwestern pennsylvania .
we excluded individuals who reported a diagnosis... | objectiveto determine the comparative effectiveness of three lifestyle intervention modalities in decreasing risk for diabetes.research design and methodsfive hundred and fifty - five individuals ( 86.1% female , 95.1% white , and 55.8% obese ) from eight rural communities were screened for bmi 25 kg / m2 and waist cir... |
prostate cancer is the second most common cancer in male worldwide , which accounts for 14.5% of all cancer , according to globocan 2012 from world health organization . in united states and europe , it is amounting to 25% of newly diagnosed cancer . in korea ,
annual incidence of prostate cancer in korea was 8.5 per... | purposewe compared location of positive cores in biopsy and location of positive surgical margin ( psm ) following radical prostatectomy.materials and methodsthis retrospective analysis included patients who were diagnosed as prostate cancer by standard 12-core transrectal ultrasonography guided prostate biopsy , and w... |
during the past decade , organic light - emitting diodes ( oled ) have been one of the most intensively explored topics in chemistry and applied physics owing to their wide applications in full - color displays with color filters , backlighting for liquid crystal displays , and general lighting sources [ 13 ] .
while... | the benzothiadiazole arylene alternating conjugated oligomers have been designed and synthesized via suzuki coupling reaction . the structures and properties of the conjugated oligomers were characterized by 1hnmr , 13cnmr , uv vis absorption spectroscopy , photoluminescence ( pl ) spectroscopy .
the luminescent me... |
ami and scd are among the most serious and catastrophic of acute cardiac disorders , accounting for hundreds of thousands of deaths each year worldwide .
although the incidence of ami has been decreasing in the us according to the american heart association , heart disease is still the leading cause of mortality in a... | acute myocardial infarction ( ami ) and sudden cardiac death ( scd ) are among the most serious and catastrophic of acute cardiac disorders , accounting for hundreds of thousands of deaths each year worldwide .
although the incidence of ami has been decreasing in the us according to the american heart association , h... |
although considerable evidences have demonstrated that percutaneous coronary intervention ( pci ) is the most advantageous and rewarding reperfusion strategy available in patients with acute st - segment - elevation myocardial infarction ( stemi ) , but they fail to restore optimal myocardial reperfusion in a sizeable ... | background : no - reflow phenomenon after percutaneous coronary intervention ( pci ) in patients with acute st - segment - elevation myocardial infarction ( stemi ) is relatively common and has therapeutic and prognostic implications .
cigarette smoking is known as deleterious in patients with coronary artery disease... |
fibromatoses / desmoid tumors are fibroblastic proliferations with an intermediate dignity between benign fibroblastic tumors and fibrosarcoma . they are characterized by an infiltrative growth pattern , high rate of local recurrence , and the inability to metastasize [ 13 ] . referring to weiss and goldblum
there ar... | background .
magnetic resonance imaging is considered as imaging modality of choice in diagnosis of desmoid tumors , though even this technique can lack the ability to distinguish aggressive fibromatosis from other benign or malignant soft tissue tumors .
the aim of this study was to investigate if desmoid tumors w... |
osseointegrated implants have provided alternative treatments to conventional prostheses for patients who lost their teeth and achieved predictable long - term results.1,2 an accurate and passively fitting prosthesis as well as successful surgical operation is suggested as one of the critical requirements for long term... | purposethe aim of this study was to evaluate the effect of dimensional stability of splinting material on the accuracy of master casts.materials and methodsa stainless steel metal model with 6 implants embedded was used as a master model .
implant level impressions were made after square impression copings were splin... |
schizophrenia is a chronic and often debilitating illness affecting approximately 1% of the world population.1 it is a complex disorder characterized by profound disturbance of perception , cognition , emotion , and social function .
the onset of schizophrenia is typically in late adolescence or early adulthood , and... | accumulating evidence suggests that neuroinflammation affecting microglia plays an important role in the etiology of schizophrenia , and appropriate control of microglial activation may be a promising therapeutic strategy for schizophrenia .
minocycline , a second - generation tetracycline that inhibits microglial ac... |
endodontic treatment of teeth is a routine therapy to treat inflammation or necrosis of the pulp .
it is established that the success rate of conventional endodontic therapy is 85% to 95% .
inspite of this high success rate , root canal therapy occasionally fails for which retreatment is needed .
however , some c... | objectives : to evaluate the efficacy of 35% orthophosphoric acid , 24% ethylenediaminetetraacetic acid ( edta ) and 10% citric acid in the removal of smear layer from retrocavities prepared with ultrasonic retro - tips using scanning electron microscopy.materials and methods : root canals of fifty single - rooted teet... |
vascular calcification is often observed in advanced vascular lesions and is a common consequence of aging , diabetes mellitus , and chronic kidney disease .
patients with diabetes mellitus or chronic kidney disease often exhibit more severe atherosclerosis and a higher prevalence of vascular calcification .
vascul... | vascular calcification , abnormal mineralization of the vessel wall , is frequently associated with aging , atherosclerosis , diabetes mellitus , and chronic kidney disease .
vascular calcification is a key risk factor for many adverse clinical outcomes , including ischemic cardiac events and subsequent cardiovascula... |
outpatients with mucocele of the glands of blandin nuhn treated with absolute ethanol at the department of oral and maxillofacial surgery , tianjin hospital for stomatology , totaled 14 patients from 2013 to 2015 . of them ,
the age range was from 6 to 30 years , with an average age of 14.4 years .
lesion dimensio... | abstractmucocele of the anterior lingual salivary glands is a more common cystic lesion , especially in patients aged less than 20 years .
the study is aimed to observe the effect of treatment by injection of absolute ethanol instead of surgery .
fourteen outpatients diagnosed as mucocele of the glands of blandin ... |
a 73-year - old man was admitted to our intensive care unit ( icu ) via the emergency department with severe diarrhea , oliguria , and generalized edema .
the patient 's vital signs were blood pressure ( bp ) 85/50 mmhg , heart rate 120 beats / min , and drowsy mental status .
his medical history included diabetes ... | coronary air embolism is a rare event .
we report a case in which an acute myocardial infarction occurred in the region supplied by the right coronary artery after the removal of a double - lumen hemodialysis catheter .
emergent coronary angiography revealed air bubbles obstructing the mid - segment of the right co... |
although differential diagnosis of deep t - wave inversion includes life - threatening conditions , such as myocardial infarction and stroke , even a thorough workup may not reveal its etiology 2 .
deep t - wave inversion is commonly associated with takotsubo cardiomyopathy or takotsubo - like myocardial dysfunction ... | key clinical messagethe electrocardiogram ( ecg ) of a 73-year - old , asymptomatic woman showed deep t - wave inversion .
the complete workup was negative .
ten years later , she developed takotsubo cardiomyopathy with abnormal ecg again .
isolated deep t - wave inversion might be an aftereffect of takotsubo car... |
cells of the immune system continually monitor a host for invading pathogens and participate in clearing those pathogens so the body remains free of infection .
this active response is an immunogenic response . under non - infectious conditions , cells of the immune system
are also continually exposed to proteins o... | dendritic cells ( dc ) are central to the immune system because of their role in antigen presentation leading to either tolerance or immunity among cells of the adaptive immune response .
it is becoming increasingly evident that dc show extensive plasticity in terms of their origin and function , giving rise to a num... |
lung cancer can be mainly classified into squmous cell carcinoma , adenocarcinoma , small cell carcinoma and the other subtypes .
it is very important to diagnose the subtype of lung cancer fast and accurately as the therapy is different .
endobronchial ultrasound - guided transbronchial needle aspiration ( ebus - ... | aims : endobronchial ultrasound ( ebus ) is a relatively new modality that can be used to guide transbronchial needle aspiration ( tbna ) of mediastinal lymph nodes . at present , researches on the sensitivity and specificity of cytopathology based on the ebus - tbna are deficient ; therefore , we want to evaluate the ... |
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