article stringlengths 0 826k | abstract stringlengths 174 4.34k |
|---|---|
the aging process is associated with heterogeneity and interindividual variability , depending on biological , psychological , social , and economic factors.1 the rate of growth of the elderly population ( persons aged 65 years and above ) in the world is on a continued increase.24 demographic projections indicate that... | backgroundthe objective of the study was to evaluate health aspects in elderly individuals in social , institutional , and home care in poland.methodsa total of 300 elderly individuals in care in poland were included in the study .
the subjects were divided into three groups : residents of long - term care institutio... |
osteoporosis , a disorder characterized by the progressive loss of bone tissue and microarchitectural deterioration , remains a public health problem and reduces the quality of life for the aging population .
it has been estimated that with increasing age , bone mineral density ( bmd ) in women decreases 1 - 2% per y... | osteoporosis and its associated fractures are common complications of aging and most strategies to prevent and/or treat bone loss focused on antiresorptive medications .
however , aerobic exercise ( aex ) and/or whole - body vibration ( wbv ) might have beneficial effect on bone mass and provide an alternative approa... |
as stated by who , each year over two million people die from diarrheal diseases , many of which are acquired from eating contaminated food from food service .
food borne diseases remain responsible for high levels of morbidity and mortality in the general population .
the most frequently reported food worker 's er... | introduction : the us centers for disease control and prevention ( usdhhs - cdc 1996 ) revealed that the outbreaks of food borne diseases include inadequate cooking , heating , or re - heating of foods consumption of food from unsafe sources , cooling food inappropriately and allowing too much of a time lapse . as we a... |
opuntia vulgaris mill ( sappattukkalli in tamil , nagophema in oriya , family : cactaceae ) is a large succulent shrub common throughout india , found widely in the northern india .
various parts of this plant were used in tribal medicine as bitter , laxative , stomachic , c native , antipyretic and cures biliousness... | the in vitro antioxidant activity of stems of opuntia vulgaris mill had been investigated by estimating degree of non - enzymatic haemoglobin glycosylation measured colorimetrically at 520 urn .
it was found that benzene and chloroform extract of o. vulgaris had better antioxidant activity than petroleum ether , ethy... |
an intubation is called difficult if a conventionally trained anaesthesiologist needs more than three attempts or more than ten minutes for a successful endotracheal intubation .
it has been estimated that inability to successfully manage difficult airways has been responsible for as many as 30% of deaths attributabl... | background and aims : diabetic patients are prone for the limited joint mobility syndrome .
the atlanto - occipital joint involvement limits adequate extension of head and neck during laryngoscopy making intubation difficult .
the collagen glycosylation starts in the fourth and fifth inter - phalangeal joints .
t... |
atrial fibrillation ( af ) is the most common permanent cardiac arrhythmia with an increased risk of stroke , congestive heart failure and overall mortality .
recent studies have shown the superiority of catheter ablation methods compared to antiar - rhythmic drug therapy with an even smaller rate of treatment - rela... | thromboembolic events are known complications of left atrial ablation therapy .
we describe a complication which may also lead to systemic thromboembolism that has not been reported so far : the formation of a moving structure attached to the fossa ovalis after an attempted transseptal puncture in a 66-year old patie... |
the skeletal muscle is the most abundant tissue in the human body comprising 4050% of body mass .
skeletal muscle protein undergoes rapid turnover , which is regulated by the balance between the rates of protein synthesis and degradation . physical activity ( exercise training ) and anabolic hormones and drugs ( spor... | we discuss the functional roles of 2-adrenergic receptors in skeletal
muscle hypertrophy and atrophy as well as
the adaptive responses of 2-adrenergic receptor expression to anabolic and catabolic conditions .
2-adrenergic receptor stimulation using
anabolic drugs... |
it is characterized by persistent , progressive limitations in airflow , which are usually associated with enhanced airway and lung - inflammatory responses to noxious particles or gases.1 systemic inflammation is associated with an accelerated decline in lung function , and is heightened during episodes of exacerbatio... | backgroundmuscle wasting and chronic inflammation are predominant features of patients with copd .
systemic inflammation is associated with an accelerated decline in lung function . in this study , the prevalence of sarcopenia and the relationships between sarcopenia and systemic inflammations in patients with stable... |
the prevalence of childhood obesity continues to increase , and obesity - related adverse conditions , such as high blood pressure , increased left ventricular mass , insulin resistance , and type 2 diabetes , are now being seen in children with increasing frequency [ 2 , 3 ] .
the association of obesity with type 2 ... | obese adolescents have high concentrations of saturated fatty acids and low omega-3 long - chain polyunsaturated fatty acids ( lcufas ) in plasma phospholipids .
we aimed to investigate effects of omega-3 lcpufa supplementation to obese adolescents on skeletal muscle lipids and glucose and insulin homeostasis .
twe... |
the current treatment recommendations for patients with oropharyngeal squamous cell carcinoma ( opscc ) remain based largely on clinical parameters such as clinical stage and performance status with less emphasis on underlying tumor biology .
the current national comprehensive cancer network ( nccn ) treatment guidel... | we evaluated a panel of 8 immunohistochemical biomarkers as predictors of clinical response to definitive intensity - modulated radiotherapy in patients with oropharyngeal squamous cell carcinoma ( opscc ) .
106 patients with opscc were treated to a total dose of 6670 gy and retrospectively analyzed for locoregional... |
panic attack is a discrete period of intense fear or discomfort , accompanied by cognitive and physical symptoms of arousal .
these include tachycardia , sweating , shortness of breath , chest pressure , choking sensations , dizziness or lightheadedness , depersonalization or derealization , stomach discomfort , and ... | panic disorder with agoraphobia is a psychological disorder . we are presenting a case report of male client ,
visted as out door patient in the counseling centre of national institute of psychology .
client reported the symptoms such as palpitations , pounding heart , accelerated heart rate , sweating , trembling ... |
pseudorabies virus ( prv ) is a member of the family herpesviridae , subfamily alphaherpesvirinae and the causative agent of pseudorabies ( pr ) or aujezsky 's disease .
infections with prv result in nervous disorders , respiratory distress , weight loss , young piglet death , and abortion .
the virus has a doubl... | pseudorabies virus ( prv ) is a double - stranded , dna - based swine virus with a genome approximating 150 kb in size .
prv has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation .
recombinant prvs expressing both native and... |
the role of endobronchial ultrasound - guided transbronchial needle aspiration ( ebus - tbna ) in the diagnosis and staging of non - small cell lung cancer has been well established as the first modality of choice . the overall sensitivity and
the negative predictive value ( npv ) of ebus - tbna in mediastinal stagin... | background and objectives : endobronchial ultrasound - guided transbronchial needle aspiration ( ebus - tbna ) is a minimally invasive procedure that has a well - established role in the diagnosis and staging of lung cancer .
this technology is also widely used for the diagnosis of mediastinal masses and cysts as wel... |
the goal of the transition strategy is to ensure a sustained hiv response through an effective transition. this goal thus emphasizes both the need for an effective transition and also the broader purpose which is to sustain impact .
the bmgf program team has been actively planning and refining the transition strate... | backgroundsustainability is the holy grail of many development projects , yet there is limited evidence about strategies that effectively support transition of programs from donor funding to national governments . the first phase of avahan , the india aids initiative supported by the bill and melinda gates foundation (... |
research describes increasing rates of obesity in women of childbearing age [ 1 , 2 ] . with more than 40% gaining in excess of institute of medicine recommendations
, pregnancy is now emerging as an important risk factor for excessive weight gain and an important target for obesity prevention studies .
although ... | few studies have investigated if compliance with energy intakes , physical activity , and weight gain guidelines attenuate postpartum weight retention ( ppwr ) in mothers attending prenatal classes .
we investigated whether ( a ) daily energy intakes within 300 kcal of estimated energy requirements ( eers ) , ( b ) ... |
, over one million people die each year and a similar number are disabled from brain injuries , often with profound effects on the quality of life of the affected individuals and their carers .
road traffic crashes account for most of the deaths , and car use is rapidly increasing in many countries .
it is estimate... | the global epidemic of head injuries is just beginning .
many are caused by road traffic crashes .
it is estimated that , by 2020 , road traffic crashes will have moved from its present position of ninth to third in the world disease burden ranking , as measured in disability adjusted life years . in developing cou... |
in their january 2013 study , fang et al . reviewed almost 20 years of cases of scientific misconduct reported by the u.s .
fang et al . further found that 65% of those who committed misconduct were male and that of the 72 faculty members who committed misconduct , 88% were male .
these norms support the possibili... | abstract in their study published in january 2013 in mbio , fang et al . reviewed records from the office of research integrity ( ori ) and found more cases of scientific misconduct committed by men than women , particularly by faculty ( f. c. fang , j. w. bennett , and a. casadevall , mbio 4:13 , 2013 ) .
powerful s... |
brachytherapy as a boost or monotherapy plays an important role in treating breast cancer [ 1 , 2 ] . in the recent years , accelerated partial breast irradiation ( apbi ) with its 4 - 5 day treatment course has been widely used worldwide to treat early stage breast cancer patients .
different techniques are availab... | in the last decades , treatment planning for multicatheter interstitial breast brachytherapy has evolved considerably from fluoroscopy - based 2d to anatomy - based 3d planning . to plan the right positions of the catheters , ultrasound or computed tomography ( ct ) imaging
can be used , but the treatment plan is alw... |
other than surgery , treatment for crc patients relies primarily on chemotherapy , especially the patients with advanced crc . among the chemotherapeutic agents for crc , 5-fluorouracil ( 5-fu ) , which is a classical chemotherapy agent ,
has been the first line regimen for treating crc over several decades [ 2 , 3 ]... | dichloroacetate ( dca ) , an inhibitor of pyruvate dehydrogenase kinase ( pdk ) , has been recently demonstrated as a promising nontoxic antineoplastic agent that promotes apoptosis of cancer cells . in the present study
, we aimed to investigate the antitumor effect of dca combined with 5-fluorouracil ( 5-fu ) on co... |
lactoferrin , the transferrin family member , is an iron - binding glycoprotein that displays anti - inflammatory , antibacterial , and immunomodulatory activities .
lactoferrin can be secreted by exocrine epithelial cells , and its concentration in normal human serum varies within the range of 27 10g / ml .
serum... | objectives . to investigate the role of the igf-1r by which lactoferrin induces osteoblast growth . methods .
osteoblast received 5 d lactoferrin intervention at a concentration of 0.1 , 1 , 10 , 100 , and 1000 g / ml , and the igf-1 and igf-1r were detected using rt - pcr and western blot .
the osteoblast into t... |
late - onset neonatal sepsis due to e. coli infection is a life - threatening condition that frequently progresses to multiple organ failure ( mof ) and carries a high mortality risk .
recent data report unfavorable outcomes in almost 50% of affected children [ 1 , 2 , 3 ] .
the milestone of septic shock treatment ... | neonatal sepsis due to e. coli is often complicated by multiple organ failure ( mof ) and a high mortality risk .
we report the case of a term newborn discharged in good condition who suddenly fell into septic shock after 11 days and required immediate resuscitation , volume expansion and a high - dosage amine infusi... |
the data in the proteomexchange archive ( pxd002264 ) provide a novel description of the human pulp proteome and n - terminome as seen by tails n - terminomics .
these data were analyzed using four different database search engines , namely mascot , x !
tandem , comet , and ms - gf+ in combination with peptidepro... | the data described here provide the in depth proteomic assessment of the human dental pulp proteome and n - terminome ( eckhard et al . , 2015 ) [ 1 ] .
a total of 9 human dental pulps were processed and analyzed by the positional proteomics technique tails ( terminal amine isotopic labeling of substrates ) n - termi... |
fungal septic arthritis is a rare disease usually caused by aspergillus species . in most of the cases
, it occurs in immunocompromised patients.1 septic arthritis is considered a medical and surgical emergency .
delay in treatment can lead to chronic irreversible joint damage and osteomyelitis.2 typically , it aff... | aspergillus septic arthritis is a rare and serious medical and surgical problem .
it occurs mainly in immunocompromised patients .
aspergillus fumigatus is the most common causative organism followed by aspergillus flavus .
the most common site affected is knee followed by shoulder , ankle , wrist , hip and sacro... |
cervical cancer is a malignancy that is the second most common cause of death from cancer in women throughout the world and different types of treatment are used for its management ( 1 ) .
based on the international federation of gynecology and obstetrics ( figo ) division , cervical cancer is a neoplasia including 4... | objective(s):cervical cancer is a malignancy that is the second most common cause of death from cancer in women throughout the world .
paederus beetle ( paederus fuscipes ) extract ( pbe ) , contains bioactive compounds such as pederine which has cytotoxic properties and blocks dna and protein synthesis at very low c... |
it was first described by burns ( 1 ) in 1811 , and named " chloroma " by king ( 2 ) in 1853 because of its green color , which is due to the presence of myeloperoxidase enzymes in the immature myeloid cells .
this disease usually arises during the course of acute myelogeneous leukemia , although it also occurs infre... | granulocytic sarcoma is a rare extramedullary tumor composed of myeloid progenitor cells .
primary involvement of the biliary tract without evidence of leukemia is exceedingly rare . here , we report an isolated biliary granulocytic sarcoma in a 30-yr - old man who presented with jaundice , fever , and chill without ... |
oral
inhalation ( oi ) is not only the preferred mode of administration
of therapeutics intended for the regional delivery to the lungs , but
it has also been recognized as a promising route for the noninvasive
delivery of drugs through the lungs , as suggested
by the many ongoing clinical trials of oi formul... | the purpose of this study was to
determine the effect of pegylation
on the interaction of poly(amidoamine ) ( pamam ) dendrimer nanocarriers
( dncs ) with in vitro and in vivo models of the pulmonary epithelium .
generation-3 pamam dendrimers
with varying surface densities of peg 1000 da were synthesized and ... |
cd2 + provokes an immediate production of inositol trisphosphate and the release of ca2 + from internal stores in human fibroblasts and some other mammalian cells .
ni2 + , co2 + , fe2 + , and mn2 + evoke the release of stored ca2 + , but are less potent than cd2 + ( apparent k0.5 = 40 nm ) .
zn2 + and cu2 + compet... | |
most transcripts encode proteins that contain a ras association domain ( ra ) , an n - terminal c1-type zinc finger , and a c - terminal sarah ( sav rassf hippo ) domain ( [ 813 ] and figure s1a ) .
rassf family members , most notably rassf1a , are frequently silenced in a variety of solid tumors , mainly by promote... | summarycorrect organ size is determined by the balance between cell death and proliferation .
perturbation of this delicate balance leads to cancer formation [ 1 ] .
hippo ( hpo ) , the drosophila ortholog of mst1 and mst2 ( mammalian sterile 20-like 1 and 2 ) is a key regulator of a signaling pathway that control... |
the sampling procedure included a random selection of three universities ( peyam noor , islamic azad and tabriz university ) at the undergraduate level in the city tabriz .
within the three universities , a total sample size of 300 freshman students with a mean age of 23.6 years ( sd=3.2 years , range=21 to 29 were s... | objectivethe present study examined the psychometric properties of the persian version of the revised cheek and buss shyness scale ( rcbs ) using confirmatory factor analysis among ( n = 300 ) college students.methoda total of 300 undergraduate students participated in this study and completed the revised cheek and bus... |
monoamine oxidase a ( mao - a ) has an important role in processes such as monoamine neurotransmitter metabolism and oxidation as well as the pathophysiology of major depressive disorder ( meyer et al , 2006 , 2009 ) , cigarette smoking ( fowler et al , 1996 ) , and aggression ( alia - klein et al , 2008 ) .
the mao ... | monoamine oxidase a ( mao - a ) is an important target in the pathophysiology and therapeutics of major depressive disorder , aggression , and neurodegenerative conditions . we measured the effect of changes in mao - a substrate on mao - a binding in regions implicated in affective and neurodegenerative disease with [ ... |
the facial nerve ( fn ) is the main anatomical structure that the surgeon should consider in performing a surgical approach to the temporomandibular joint ( tmj ) .
preservation of the functional integrity of the fn is a critical measure of success in tmj surgery .
impairment of fn function interferes with emotiona... | background : preservation of the functional integrity of the facial nerve ( fn ) is a critical measure of success in temporomandibular joint ( tmj ) surgery . in spite of the development of a myriad of surgical approaches to the tmj , fn remains at risk .
the deep subfascial approach provides an additional layer of p... |
gastric cancer is the fourth most prevalent malignancy worldwide , and is responsible for the third greatest number of deaths due to cancer .
the spread of gastric cancer can occur as a consequence of lymphatic dissemination or by direct invasion of adjacent structures .
recurrence of gastric cancer is common , wit... | gastric cancer is a common malignancy with high recurrence rates following surgical resection .
a common site of disease recurrence is the peritoneum .
we report the case of a 73-year - old female who had previously undergone a total gastrectomy for gastric cancer who presented acutely with features classical of ac... |
waste management practices , especially the solid waste , differ significantly for developed and developing countries , for urban and rural areas , and for residential , commercial , and industrial producers .
for instance , in ghana , urban domestic waste collection services are often provided by local government au... | the comparative analysis of solid waste management between rural and urban ghana is largely lacking .
this study investigated the solid waste situation and the organisation of solid waste management in both urban and rural settings from the perspective of households .
the study employed cross - sectional survey cov... |
cannabis contains a series of compounds , but it has been found that the major psychoactive ingredient is 9-tetrahydrocannabinol ( thc ) ( mechoulam and gaoni 1967 ) .
two selective cannabinoid receptor subtypes have been identified so far ( matsuda et al 1990 ; munro et al 1993 ) , cb1 and cb2 , that are expressed i... | the endocannabinoid system and cannabinoid - based treatments have been involved in a wide number of diseases . in particular
, several studies suggest that cannabinoids and endocannabinoids may have a key role in the pathogenesis and therapy of multiple sclerosis ( ms ) . in this study
we highlight the main findin... |
we report an osteoarthritic patient with huge sub - chondral cyst - like lesions in the anterior part of distal femur .
deep and large bone defects and severe lateral laxity due to advanced osteoarthritis was successfully treated with semi - constrained type total knee arthroplasty with long stem .
she was posted f... | introduction : we report an osteoarthritic patient with huge sub - chondral cyst - like lesions in the anterior part of distal femur . deep and large bone defects and severe lateral laxity due to advanced osteoarthritis was successfully treated with semi - constrained type total knee arthroplasty with long stem.case re... |
the turner syndrome is caused by the absence of 1 set of genes from the short arm of 1 x chromosome and presents with characteristic physical abnormalities such as short stature , amenorrhea due to ovarian failure , retruded mandible , ptosis , low hair line , low - set ears , webbed necks , renal structural anomalies ... | chromosomal translocations constitute one of the most important , yet uncommon , causes of primary amenorrhea and gonadal dysgenesis .
although x - autosome translocations are frequently associated with streak gonads and clinical features of the turner syndrome , the majority of x - autosome carriers may present with... |
human immunodeficiency virus ( hiv ) causes incurable disease of adaptative immunodeficiency syndrome ( aids ) , as one of the major global health problems ( 1 , 2 ) . the world health organization ( who ) maintains that more than 35.9 million people worldwide are living with hiv / aids ( 3 ) .
the most common source... | background : cell - mediated immunity ( cmi ) by cd4 + th ( t helper)-type cells is the predominant host defense mechanism against oral candidiasis ( oc ) in hiv - infected individuals . weakened cmi and depletion of cd4 + t cells are the main factor contributing to the output of oc in hiv - positive individuals .
th... |
the process of tissue healing is very complex and involves vascular and cellular changes , epithelial proliferation , fibroblast proliferation , synthesis and deposition of collagen , production of elastin and proteoglycans , revascularization , and wound contraction .
the incorporation of laser as a therapeutic tool... | background : the effectiveness of low power lasers on incisional wound healing , because of conflicting results of previous studies , is uncertain .
therefore , the aim of this study was to evaluate the effects of low - level helium - neon ( he - ne ) laser irradiation on wound healing in rat 's oral mucosa.materials... |
pruritus is a common and serious problem among hemodialysis patients.1 a brief literature review showed that pruritus is a problem with a large variation of incident rates between countries as well as between facilities ( 36%50% and 5%75% , respectively).1 in japan , severity of patient - reported pruritus symptoms exp... | introduction and objectivewhile pruritus is a common complication in hemodialysis patients , the pathophysiological mechanisms remain obscure .
recently , b - type ( brain ) natriuretic peptide ( bnp ) has been defined as an itch - selective neuropeptide in pruriceptive neurons in mice , and higher serum levels of bn... |
breast cancer is a complex disease that results from the most frequent non - skin cancer to affect women a multi - stage process involving the deregulation of worldwide , and remains one of the top public health a number of different signalling cascades .
there are about 212,930 new cases of breast cancer diagnosed e... | abstractthe thiazolidinediones ( tzds ) are a class of synthetic antidiabetic drugs exerting its action primarily upon acti - vation of the peroxisome proliferator - activated receptor- ( ppar ) . given the widespread incidence of diabetes type ii and lifelong exposure of these patients to tzds
, there is a possibili... |
primary lymphoma of the bone ( pbl ) is a rare neoplasm accounting for less than 5% of all malignant bone tumors and almost 7% of all extranodal lymphomas.1 occasionally , it may involve the vertebrae and encroach upon the nerve root , causing claudication and radicular syndrome mimicking spinal stenosis.1 we report a ... | primary bone lymphoma ( pbl ) comprises less than 5% of all malignant bone tumors and almost 7% of all extranodal lymphomas .
only 1.7% of all pbls have been reported to involve the vertebrae . in our case ,
osteomyelitis was accidentally found during surgery , which might have resulted in the rapid collapse of ver... |
in the brain , glutamate mediates excitatory synaptic transmission , responsible for learning , memory formation and cognition .
glutamate transporters are electrochemically driven pumps that maintain a low neurotransmitter background at glutamatergic synapses , allowing for repeated rounds of signaling and preventin... | summaryglutamate transporters are integral membrane proteins that catalyze neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons1 .
their mechanism involves transitions between extracellular- ( outward- ) and intracellular- ( inward- ) facing conformations , whereby substrate b... |
proteomics is the use of gel electrophoresis and/or chromatography combined with mass spectrometry ( ms)-based methods to identify and quantify proteins from complex samples , e.g. blood or urine , with the aim of increasing our understanding of the proteins , their function , interactions , expression control and othe... | controlled vocabularies ( cvs ) , i.e. a collection of predefined terms describing a modeling domain , used for the semantic annotation of data , and ontologies are used in structured data formats and databases to avoid inconsistencies in annotation , to have a unique ( and preferably short ) accession number and to gi... |
optical coherence tomography ( oct ) based on low coherence interferometry is a well - established imaging technique thanks to its prominent axial resolution . since 2006 , commercially available oct systems perform visualization of tissue microstructure in the so - called fourier domain ( fd - oct ) . differently to t... | this paper presents a novel processing technique which can be applied to corneal in vivo images obtained with optical coherence tomograms across the central meridian of the cornea .
the method allows to estimate the thickness of the corneal sublayers ( epithelium , bowman 's layer , stroma , endothelium , and whole c... |
chronic diseases are considered as the major public health problems of today s world ( or within contemporary societies ) .
diabetes is one of the most important metabolic dysfunctions which is often asymptomatic in the early stages that manifests as chronic hypoglycemia which causes damage to body organs while incre... | background : gestational diabetes ( gd ) is one of the major public health issues . the purpose of the present study was to perform a systematic review and meta - analysis to assess the risk factors and prevalence rate of this disorder in iran.methods:this systematic review and meta- analysis article was prepared using... |
the most popular class of models seeking to explain perceptual alternations during binocular rivalry are built on the concepts of mutual inhibition , an idea dating back over a century ( breese , 1899 ) .
while the details vary among models , the general idea is that pools of neurons representing possible alternative... | fluctuations in perceptual dominance during binocular rivalry exhibit several hallmark characteristics .
first , dominance switches are not periodic but , instead , stochastic : perception changes unpredictably .
second , despite being stochastic , average durations of rivalry dominance vary dependent on the streng... |
muscle power is defined as high - intensity muscular performance in a short term and is composed of speed and strength .
both familial and twin studies suggest that genetic factors in power , speed and strength account for 35%~80% of inter - individual variation [ 6,28 - 30 ] . during the last two decades
, there h... | [ purpose]the aim of this study is to examine the association between the distribution of actn3 genotypes and alleles in power , speed , and strength - oriented athletics.[methods]actn3 genotyping was carried out for a total of 975 korean participants : top - level sprinters ( n = 58 ) , top - level strength athletes (... |
the antitumor agent bleomycin is the prototypic
sequence - selective
dna cleaving agent . that property has been studied intensively for
decades in the belief that it must form the basis for the antitumor
activity of bleomycin ( blm ) .
of special interest was the finding of double - strand
dna cleavage at ... | clinically
used bleomycin a5 has been employed in a
study of double - strand cleavage of a library of 10 hairpin dnas originally
selected on the basis of their strong binding to bleomycin .
each of
the dnas underwent double - strand cleavage at more than one site , and
all of the cleavage sites were within ... |
infection by cytomegalovirus ( cmv ) is not a rare disease and is frequently observed in immunocompromised hosts with hematological / immunological diseases or under treatment with glucocorticoids or immunosuppressants .
the majority of patients with cmv infection are asymptomatic or minimally symptomatic , while cmv... | cytomegalovirus ( cmv)-associated gastric ulcers can be found not only in immunocompromised hosts but also in normal individuals .
the accurate endoscopic diagnosis of cmv ulcers is not easy because of the absence of characteristic morphological features .
we present a case of cmv - associated gastric ulcer in an i... |
as a part of the age - associated deterioration of the immune system [ 13 ] , there is a chronic proinflammatory state even in the absence of clinically - apparent disease .
inflamm - aging is characterized by elevated circulating levels of proinflammatory factors ( il-1 , il-6 , tnf , and prostaglandin e2 ) and... | here , we studied in vitro cytokine production by splenic macrophages obtained from young and aged balb / c wild type ( wt ) and il-6 knockout ( il-6 ko ) mice .
relative to macrophages obtained from young wt mice given lipopolysaccharide ( lps ) , those from aged wt mice had decreased production of proinflammatory c... |
advances in biomedical science and technology have brought the hope of survival to more and more children and youth with complex needs .
many of them now live into adulthood and function in the community . accordingly ; a growing interest has emerged in the children 's quality of psychosocial life in spite of the c... | purpose . to explore the associations and interactions among ecological factors and explain the psychosocial quality of life of children with complex needs
. methods . in this cross - sectional survey
consenting parents were identified by the children 's treatment network .
families were eligible if the child fro... |
prostate cancer has historically been considered a chemotherapy - resistant disease.1,2 however , over the past few decades , with the development of better cytotoxic agents and improved trial designs focused on clinically relevant endpoints , an important role for chemotherapy in the treatment of castration resistant ... | castration resistant prostate cancer has historically been considered chemotherapy insensitive . however , the approval of estramustine phosphate , mitoxantrone , and docetaxel , over the past few decades , has challenged this notion . despite these advances , until recently , only docetaxel had been shown to improve s... |
the innate immune system or the nonspecific immune system is the first and the oldest line of defense in organisms [ 1 , 2 ] .
it was the most dominant form of immunity before the evolution of the more sophisticated adaptive immunity .
it is comprised of various mechanisms which are responsible for rapid defense of... | lactoferrin is a multifunctional , iron - binding glycoprotein which displays a wide array of modes of action to execute its primary antimicrobial function .
it contains various antimicrobial peptides which are released upon its hydrolysis by proteases .
these peptides display a similarity with the antimicrobial ca... |
primary lung leiomyosarcoma is a rare malignant tumor , arising from the smooth muscle of the bronchi , bronchioles or bronchial arterioles occurs in adults .
the endobronchial form is exceptional in that only 14 patients older than 20 years have been reported .
we report two cases of primary endobronchial leiomyos... | primary leiomyosarcoma of the lung is an unusual malignant tumor . among this entity ,
the endobronchial form is very rare and the preoperative diagnosis is extremely difficult .
we present two different presentations and outcomes of primary endobronchial leiomyosarcoma of the lung . in both cases ,
the histologi... |
endometrial carcinoma is one of the most common gynecologic malignancies . although it is primarily a disease of postmenopausal women , 25% of patients are in the premenopausal period , and 3 - 5% are < 40 years of age .
obesity and chronic anovulation are major risk factors of endometrial carcinoma in young women [ ... | a 20-year - old obese thai woman with polycystic ovary syndrome and clinical stage i well - differentiated endometrial carcinoma denied surgical staging .
chest x - ray and magnetic resonance imaging of the whole abdomen suggested neither distance metastasis nor local invasion of the cancer .
after 3 months of syst... |
worldwide , there is a consensus that low - and middle - income countries are passing through an epidemiological transition .
the pattern of childhood mortality and morbidity is changing from infectious diseases to noncommunicable diseases and injuries in these countries .
although , childhood injuries are a major ... | introduction . the paper aims to explore the magnitude and distribution of unintentional injuries among bangladeshi children ( < 18 years ) . methodology .
a cross sectional survey was conducted during 2003 ( january to december ) in 12 randomly selected districts and dhaka metropolitan city of bangladesh .
nationa... |
empd is an intraepithelial adenocarcinoma characterized by a chronic eczema - like rash and/or dermatophyte infection - like lesion mainly in the external genital and axillary regions .
empd in its early stage is usually not invasive and metastatic ; therefore , it is simply treated by surgical excision . however , o... | extramammary paget 's disease ( empd ) is an uncommon cutaneous adenocarcinoma arising from the apocrine glands within the epidermis or underlying skin appendages in the anogenital and axillary regions .
surgical excision is basically performed as a treatment for empd . however , therapeutic options for empd in an ad... |
a 44-year - old lady presented to us with complaints of dull aching continuous pain in the right flank region for 1 year .
she had intermittent acute exacerbations of pain associated with nausea / vomiting requiring hospitalization for pain relief .
there was no associated fever , hematuria , lithuria , or lower ur... | schwannoma is a benign soft tissue tumor of neural origin arising from the schwann cells of the neural sheath .
it has rarely been reported in renal or perirenal region .
the preoperative diagnosis has mostly been confused with renal cell carcinoma in this location in most previous reports .
we report a case that... |
histone proteins package eukaryotic dna into chromatin , a multilevel array in which nucleosomes comprise the basic unit .
the nucleosome consists of a core , ~147 base pairs ( bp ) wrapped around a histone octamer in 1.67 left - handed turns , in addition to a variable length of linker dna . by influencing dna site ... | high mobility group n proteins ( hmgns ) bind specifically to the nucleosome core and act as chromatin unfolding and activating factors .
using an all - xenopus system , we found that hmgn1 and hmgn2 binding to nucleosomes results in distinct ion - dependent conformation and stability .
hmgn2 association with nucle... |
calciphylaxis is characterized by painful , necrotic ulcerations that often manifest in small to medium sized arteries ( < 0.6-mm diameter ) .
the most commonly affected sites are the lower extremities but reports of calciphylaxis occurring in hands , fingers , tongue , abdomen , and buttocks have also been noted .
... | calciphylaxis or uremic arteriolopathy is a complex process typically seen in patients with end - stage renal disease , but has also been reported in patients with normal renal function .
however , therapies for calciphylaxis are based on reports of traditional patients ( i.e. , end - stage renal disease ) .
a main... |
dental anomalies that might affect the size , shape , or number of teeth are often detected during a routine clinical examination or incidentally .
early detection and diagnosis of such anomalies are essential for proper management and treatment to prevent future clinical problems and complications .
a supernumerar... | objective : there is no data specific to the qatari population on the prevalence and distribution of hyperdontia .
the aim of this study was to investigate the prevalence and distribution of hyperdontia in the permanent teeth among a group of qatari sample and to compare the present results with findings from other p... |
treatment with vitamin k antagonists ( vka ) is complex and requires frequent analytical work - ups and visits to monitor the international normalized ratio ( inr ) .
this treatment can affect patients ' assessment of health - related quality of life ( hrqol ) in that it requires changes in lifestyle and not provide ... | new oral anticoagulants ( noac ) have demonstrated their efficacy as an alternative to vitamin k antagonists ( vka ) in the prophylaxis of cardioembolic events in patients with atrial fibrillation ( af ) .
however , evidence on the benefits of noac in health - related quality of life ( hrqol ) is lacking.we evaluated... |
meckel 's diverticulum ( md ) is a true diverticulum that develops from the incomplete obliteration of the omphalomesenteric duct during embryonic development .
the common complications caused by md include hemorrhage associated with peptic ulceration from heterotopic gastric mucosa located within the diverticulum an... | meckel 's diverticulum ( md ) is a common congenital anomaly of the gastrointestinal tract , the majority of cases of which are clinically silent .
patients with asymptomatic md can unexpectedly develop acute abdominal pain . making a diagnosis of md
is often difficult due to the lack of specific symptoms caused by... |
kasabach - merritt syndrome ( kms ) describes a consumptive coagulopathy associated with certain vascular tumors .
it is thought that platelets are destroyed as they circulate through the aberrant endothelial surfaces associated with these tumors .
most published literature describes infants with kaposiform hemangi... | |
over the past decades , improvements have been made in the design and hemodynamics of mechanical valve prostheses in order to reduce valve dysfunction and increase durability . however , prosthetic stenosis due to thrombus or pannus is still one of the most frequent complications and it can be severe , evolving into ca... | pannus - related prosthetic valve dysfunction , a complication of mechanical prosthetic valve replacement , is rare , with a slowly progressive evolution , but it can be acute , severe , requiring surgical reintervention .
we present the case of a patient with a mechanical single disc aortic prosthesis , with moderat... |
in 2001 , the default mode network ( dmn ) was first proposed as an interconnected set of brain regions that is active when the brain is in a resting state and typically deactivated during memory encoding and other cognitively demanding tasks focused on processing of external stimuli .
the dmn includes the dorsal and... | the spatial correlations between the brain 's default mode network ( dmn ) and the brain regions known to develop pathophysiology in alzheimer 's disease ( ad ) have recently attracted much attention . in this paper , we compare results of different functional and structural imaging modalities , including mri and pet ,... |
adolescents with type 1 diabetes were eligible for this study if they did not have a major psychiatric / neurocognitive disorder that would inhibit ability to participate , a significant medical disease other than type 1 diabetes , or the inability to read or understand english . at the northeastern clinical site ,
a... | objectiveto determine whether the association between depressive symptoms and glycemic control is mediated by blood glucose monitoring ( bgm).research design and methodsa total of 276 adolescents with type 1 diabetes ( mean age sd , 15.6 1.4 years ) completed a measure of depressive symptoms .
sociodemographic and ... |
the american heart association reports that
one in five americans over the age of 40 will develop congestive heart failure
( chf ) .
this common clinical syndrome is among the top
diagnostic - related
groups ( drgs ) , and is a leading cause of hospitalizations and
rehospitalization in industrialized countr... | an estimated 5 million americans have congestive heart failure ( chf ) and one in five over the age of 40 will develop chf .
there are numerous examples of chf patients living beyond the years normally expected for people with the disease , usually attributed to taking an active role in disease management .
a relat... |
desmosomes and fasciae adhaerentes ( sing . , fascia adhaerens ) , the latter also termed adherens junctions are responsible for cell cell adhesion and are often subsumed under the collective term adhering junctions . in various epithelia , like in the multistratified skin epithelium , desmosomes , and adherens juncti... | in contrast to epithelial cells , cardiomyocytes are connected by complex hybrid - type adhering junctions , termed composite junctions ( areae compositae ) .
composite junctions are found to be composed of typical desmosomal as well as adherens junction proteins .
therefore , in adult mammalian cardiomyocytes desm... |
the annual occurrence of malignant melanoma has been dramatically increasing over the past few decades , and the exposure to ultraviolet light is assumed to be a major risk factor .
other risk factors including the high number of typical melanocytic nevi , presence of atypical nevi , personal history of melanoma , an... | melanocytic nevus is the benign proliferation of melanocytes .
the most common location of melanocytic nevus is the skin of the extremities ; however , there are few case reports of melanocytic nevus at the rectal mucosa .
no prior case of malignant melanoma from melanocytic nevus at the rectal mucosa has been repo... |
unified , structured vocabularies and classifications freely provided by the gene ontology ( go ) consortium ( ) are widely accepted in most of the large scale gene annotation projects .
three ontologies ( molecular function , biological process and cellular component ) were developed to represent common and basic bi... | unified , structured vocabularies and classifications freely provided by the gene ontology ( go ) consortium are widely accepted in most of the large scale gene annotation projects .
consequently , many tools have been created for use with the go ontologies .
wego ( web gene ontology annotation plot ) is a simple b... |
heat - shock proteins
are a highly conserved family of molecular
chaperones that facilitate the folding , stability , and cellular localization
of their substrate proteins .
up - regulation
of the pathways associated with the heat - shock response has been implicated
in a number of disease areas , including... | hsp70 is a molecular
chaperone and a key component of the heat - shock
response . because of its proposed importance in oncology
, this protein
has become a popular target for drug discovery , efforts which have
as yet brought little success .
this study demonstrates that adenosine - derived
hsp70 inhibit... |
in mammalian organisms , the circadian machinery ( ie , the biological time - keeping mechanisms which maintain 24-hour oscillations in cellular and physiological processes ) is organized as a hierarchical , interconnected network of clocks .
the peripheral clocks are distributed across all cells and need to be synch... | the feeding and fasting cycles are strong behavioral signals that entrain biological rhythms of the periphery .
the feeding rhythms synchronize the activities of the metabolic organs , such as liver , synergistically with the light / dark cycle primarily entraining the suprachiasmatic nucleus .
the likely phase mis... |
avaliar a prevalncia da experimentao de cigarro em adolescentes com asma ou de rinite alrgica .
estudo transversal envolvendo escolares com 13 - 14 anos de idade na cidade de belo horizonte ( mg ) .
os escolares preencheram os questionrios do centers for disease control and prevention e do international study of as... | objective : to determine the prevalence of smoking experimentation among adolescents with asthma or allergic rhinitis . methods : this was a cross - sectional study involving adolescent students ( 13 - 14 years of age ) in the city of belo horizonte , brazil .
the participants completed the centers for disease contro... |
the reconstruction of the elbow area is always a challenge in the field of plastic surgery .
a very soft skin is covering noble anatomical tissues that include the brachial , radial and ulnar arteries as well as the ulnar , radial and median nerves [ 13 ] .
moreover , the elbow joint is very sensitive to trauma a... | covering the elbow soft tissue defects is a difficult task for the plastic surgeon . because of , the important anatomical structures situated superficially and the high tendency for stiffness of the elbow
, the reconstructive method must be chosen carefully .
traditionally the free flaps were the choice method for... |
colorectal endoscopic submucosal dissection ( c - esd ) is a promising , minimally invasive treatment developed as an alternative to surgery .
however , this may result in the creation of a large mucosal defect , which sometimes causes adverse events ( aes ) , such as bleeding , perforation , and electrocoagulation s... | background and study aims complete closure of large mucosal defects after colorectal endoscopic submucosal dissection ( c - esd ) is considered impossible in most cases because of the limited width of the open clip .
we therefore invented a simple closure technique using clip - and - line , named line - assisted co... |
the study was conducted in 2 health care and demographic surveillance sites in hanoi province , vietnam : ba vi district ( rural ) and dong da district ( urban ) .
each site contained 11,000 households that were selected by cluster sampling to represent the district population ( 12 ) .
this study was approved by et... | we assessed consumption of raw pig blood , which is a risk factor for streptococcus suis infection in vietnam , by using a mix - method design .
factors associated with consumption included rural residency , age , sex , occupation , income , and marital status .
we identified risk groups and practices and perceptio... |
celiac disease ( cd ) , or gluten - sensitive enteropathy ( gse ) , is an autoimmune disorder characterized by reversible small bowel mucosal inflammation with villous atrophy affecting patients with a specific genetic predisposition ( hla dr3-dq2 and hla dr4-dq8 ) .
the mucosal lesion develops after ingestion of die... | this communication reviews recent literature and summarizes hepatobiliary abnormalities that may complicate the clinical course of celiac disease .
a wide spectrum of hepatobiliary diseases has been described , including asymptomatic elevations of liver enzyme levels , nonspecific hepatitis , nonalcoholic fatty liver... |
idiopathic nephrotic syndrome ( ins ) is defined by altered permselectivity of the glomerular filter associated with non - specific histological abnormalities of the kidney ( 1 , 2 ) .
it is the most common type of nephrotic syndrome ( ns ) in children worldwide as compared to hereditary or secondary types .
its in... | introductionimmunosuppressive agents are recommended for the management of children with steroid - resistant ( srns ) , frequently - relapsing ( frns ) , and steroid - dependent idiopathic nephrotic syndrome ( sdns ) .
this study evaluated the efficacy of immunosuppressive agents in these cases.methodsthis is a retro... |
thirty years ago virtually nothing was known of the genetics of the retina , and none of the genes responsible for any of the various inherited pathologies of the retina in man had been identified .
but since 1980 a veritable zoo of more than 200 genes causing human retinal pathologies ( retnet , http://www.sph.uth.t... | despite the intensity of the search for genes causing inherited retinal degenerations over the past 3 decades , of the approximately 200 disease genes identified to date , all appear to be ordinary housekeeping genes specifying proteins playing basic structural and functional roles in the mature photoreceptor cells . n... |
word frequency is the most important variable in predicting word processing efficiency : high - frequency words are processed faster than low - frequency words , as measured , for instance , with lexical decision and word naming . in recent years , however , it has become clear that not all word frequency estimates are... | in this perspective article we assess the usefulness of google 's new word frequencies for word recognition research ( lexical decision and word naming ) .
we find that , despite the massive corpus on which the google estimates are based ( 131 billion words from books published in the united states alone ) , the goog... |
cancer caused 7.6 million deaths in 2008 , and it is estimated that it will cause 13.1 million deaths in 2030 ( globocan 2008 , iarc ) .
accordingly , the cancer drug market is rapidly evolving to keep up with the increasing numbers of cancer patients .
interestingly , 18% of all global sales of the top 100 drugs ,... | cancer remains a lethal disease , and many scientists are currently trying to develop more effective therapies .
natural compounds are potential sources of anti - cancer therapies and are obtained from diverse sources including marine organisms , microorganisms and plants . in this paper , we evaluated natural compou... |
mental retardation is a constant state of regression and inadequacy in effective adaptive behaviours that arises as a result of ongoing senescence , discontinuation and regression in development and functionality due to various reasons before birth , during birth and after birth . according to the world health organisa... | background : the study was carried out with the aim of determining the factors affecting and to evaluate anxiety situations and self - esteem of children with and without mentally retarded siblings.materials and methods : the sampling included 227 healthy children : 108 of them have mental retarded sibling and 119 of t... |
in the following section it will be seen that we do not yet understand what determines the gravitational potentials within the universe on scales from galaxies upwards .
one suggestion is that the universe is full of material that does not emit electromagnetic radiation and which is thus hard to
see. there are a tr... | there is now an enormously rich variety of experimental techniques being brought to bear on experimental searches for dark matter , covering a wide range of suggested forms for it .
the existence of dark matter , in some form or other , is inferred from a number of relatively simple observations and the problem has... |
fasting in the holy month of ramadan is one of the five pillars of islam .
individuals must refrain from eating , drinking , and using oral medication between dawn and sunset .
depending on the season and geographic setting , the duration of the daily fast may range from 12 to 20 h. ramadan fasting has several pote... | background and objective : studies have shown that pre - ramadan structured educational program for patients with diabetes mellitus ( dm ) is beneficial . in this study ,
our aim was to evaluate the degree of adherence of treating physicians to such programs and their influence on the patient 's knowledge and behavio... |
dexmedetomidine ( dex ) is a 2 adrenoceptor ( 2-ar ) agonist and has been widely used in clinical anesthesia and intensive care units ( icu ) because of its sedative and analgesic effects .
emily et al . found that dex at low concentration ( 10 to 310 m ) has a vascular relaxation effect , while dex at higher conce... | backgroundstudies in vivo have shown that dexmedetomidine ( dex ) could protect the myocardium and modulate the coronary blood flow .
this study aimed to investigate the direct and concentration - dependent effects of dex on the tone of porcine coronary artery in vitro and the underlying mechanisms.material/methodsdi... |
it is an opportunistic fungal infection that is caused by normal saprobic organisms of the class zygomycetes including such genera as mucor , absidia , rhizopus and cunninghamella .
numerous spores may be liberated into the air and inhaled by human hosts , from where it can spread to the brain .
infection commonly ... | mucormycosis is a rare opportunistic infection caused by fungus belonging to the order mucorales .
a case of a controlled diabetic male with rhino maxillary mucormycosis , with cerebral extension , is described .
the patient presented with hemifacial swelling , a nasal twang in his voice , fever , ocular signs , gr... |
improved outcome in the treatment of locally advanced rectal cancer ( larc ) is related to the introduction of total mesorectal excision ( tme ) and neoadjuvant treatment [ 13 ] . in locally advanced rectal cancer ( larc )
the use of neoadjuvant chemoradiotherapy ( crt ) reduces locoregional recurrence and can lead t... | goal . to evaluate the prognostic value of mandard and dworak grading systems regarding neoadjuvant chemoradiotherapy ( crt ) response on rectal cancer .
materials and methods .
we queried our center 's database for patients with colo rectal cancer with locally advanced rectal cancer ( larc ) who received neoadjuva... |
information literacy is the ability to recognize the need for information , locate relevant information , evaluate information , and use information in an ethical way ( 1 , 2 , 25 ) .
it is crucial that undergraduate biology students develop information literacy and scientific writing skills early in their undergradu... | many undergraduate students lack a sound understanding of information literacy . the skills that comprise information literacy are particularly important when combined with scientific writing for biology majors as they are the foundation skills necessary to complete upper - division biology course assignments , better ... |
host systems that can
spontaneously self - assemble and stably encapsulate
guest molecules under one set of conditions , but disassemble and release
the guest molecules when external conditions change , have been of
great interest in supramolecular chemistry due to implications in
a variety of biomedical appl... | we use monodisperse
dendrons that allow control over functional
group presentation to investigate the influence of the location of
a ligand on protein - induced disassembly and release of encapsulated
small molecules . based on both experiments and molecular dynamics
simulations ,
we demonstrate that ligand... |
postural anomalies are widespread and are exhibited by people of all demographics . while
commonly attributed to lack of physical activity , poor posture is especially prominent in
individuals who spend long periods of time sitting at a desk or computer , as is necessary
with many jobs in developed countries1,2,3... | [ purpose ] to determine the intra- and inter - rater agreement of a mobile application ,
posturescreen mobile ( psm ) , that assesses static standing posture .
[ subjects
and methods ] three examiners with different levels of experience of assessing posture , one
licensed physical therapist and two untrained u... |
cervical mediastinoscopy can provide minimally invasive access to the para - tracheobronchial mediastinum within its reachable range , but its operability is substantially limited because of its narrow operative field , poor visualisation , and one - handed operation .
the invention of the linder - dahan video medias... | highlightsschwannoma / parathyroid cyst was resected using linder - dahan video mediastinoscope.resection with video , spreadable blades , and a scope - holding device was excellent.linder-dahan video mediastinoscopy improves safety , preciseness , and operability.linder-dahan video mediastinoscopy has similar invasive... |
obesity and osteoporosis are two important and growing public health problems worldwide [ 13 ] , and osteoporotic fractures are among the main concerns of elderly population . low bone mineral density ( bmd ) is a major risk factor for osteoporosis and its related fractures .
relationship between body mass index ( bm... | objective .
although several studies have investigated the association between body mass index ( bmi ) and bone mineral density ( bmd ) , the results are inconsistent .
the aim of this study was to further investigate the relation between bmi , weight and bmd in an iranian men population . methods . a total of 230 ... |
the association between smoking and periodontal disease has consistently demonstrated negative effects and greater probabilities of established periodontal disease among smokers in comparison with non - smokers .
as we get closer to the effects , it has been established that smoking is a significant risk factor in th... | objective : smoking is detrimental to gingival and periodontal health .
it has been reported to produce changes in gingival crevicular fluid ( gcf ) flow , but the cumulative effects of smoking on gcf have not been studied till date . the present study was designed to discover and evaluate transitional dynamics , if ... |
post - exercise hypotension ( peh ) is characterized by a blood pressure ( bp ) value that is lower than the pre - exercise value that persists for minutes or hours after an exercise session.1 although the first report on peh2 was published over 100 years ago , systematic investigations of this phenomenon did not begin... | background : several studies have reported the phenomenon of post - exercise hypotension . however , the factors that cause this drop in blood pressure after a single exercise session are still unknown.objective:to investigate the effects of aerobic exercise on the acute blood pressure response and to investigate the i... |
glomangiopericytoma is a sinonasal type hemangiopericytoma that accounts for less than 0.5% of all sinonasal tumors .
histologically , this tumor is composed of very diffuse subepithelial proliferation of closely - packed spindle cells growing in various patterns .
immunohistochemical staining reveals a strong posi... | a 60-year - old woman suffered from recurrent femur neck fracture .
laboratory data showed serum hypophosphatemia , elevated alkaline phosphatase , normal serum calcium levels , and normal parathyroid hormone levels .
radiological examinations revealed a tumor in the right maxillary alveolar bone .
the nasal cavi... |
in fact , it is a worldwide problem that is growing in unprecedented dimensions . globally ,
, it was estimated that over 171,000 canadian 's faced a new diagnosis of cancer and a staggering 75,300 canadians died of cancer . the growing number of individuals diagnosed with cancer is primarily related to the increasin... | having enough staff to provide high - quality care to cancer patients will become a growing issue across canada over the next decades .
statistical predictions indicate that both the number of new diagnoses and the prevalence of cancer will increase dramatically in the next two decades .
when combining these trends... |
the importance of adenosine and atp in regulating many biological functions has long been recognized , especially for their effects on the cardiovascular system [ 1 - 5 ] .
it is known that adenosine and atp are key factors in the regulation of coronary blood flow , inhibition of platelet aggregation , protection of ... | objective : to study the effect of exercise preconditioning on adenosine 5triphosphate ( atp ) metabolism in red blood cells and cardiovascular protection against injury induced by isoproterenol in vivo .
methods : male sprague dawley rats ( sdr ) were each exercised on a treadmill for 15 minutes at 10 m / min and 10... |
since 1998 , thirteen complete rickettsia genome sequences have been reported ( www.ncbi.nlm.nih.gov/genbank/index.html ) . in addition , the national center for biotechnology information ( ncbi ) genome project for r. japonica strain yh has recently concluded ( project i d 38487 ) .
results of this project show spec... | we developed a specific and rapid detection system for rickettsia japonica and r. heilongjiangensis , the causative agents of spotted fever , using a taqman minor groove binder probe for a particular open reading frame ( orf ) identified by the r. japonica genome project .
the target orf was present only in r. japoni... |
the au nanowires were fabricated by electrodeposition into nanoporous alumina templates in a three - electrode set up 30 . a thick cu layer ( ~ 2 m ) sputtered at the back of the template served as the working electrode , ag / agcl served as a reference electrode , and a pt mesh served as counter electrode .
a dc vol... | precise delivery of molecular doses of biologically active chemicals to a pre - specified single cell among many , or a specific sub - cellular location , is still a largely unmet challenge hampering our understanding of cell biology .
overcoming this could allow unprecedented levels of cell manipulation and targeted... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.