article stringlengths 0 826k | abstract stringlengths 174 4.34k |
|---|---|
the transurethral suprapubic endo - cystostomy device ( t - spec ) is a novel disposable medical device used for insertion of a suprapubic catheter ( spc ) via a transurethral approach ( fig .
t - spec device compensates for abdominal girth to allow accurate and efficient catheter placement from an inside - out dire... | objectives
to prospectively evaluate the new medical device transurethral suprapubic endo - cystostomy ( t - spec ) , used for suprapubic catheter ( spc ) placement via the transurethral ( inside - to - out ) approach , and examine the 30-day outcomes in the first us series.methodsirb approval was obtained for this p... |
the 13th world congress on medical and health informatics ( medinfo ) was held in 2010 between 12 and 15 september in cape town , south africa .
this triennial international gathering is the official conference of the international medical informatics association ( imia ) and brings together leading health informatic... | |
testicular torsion occurs at a frequency of 1 in 4000 in men who are younger than 25 years old .
it is a common urologic emergency that leads to testicular necrosis and results in decreased fertility .
the primary pathophysiologic event in testicular torsion is ischemia followed by reperfusion ; thus , testicular t... | purpose . to investigate the protective effects of lipoxin a4 ( lxa4 ) in rat testis injury following testicular torsion / detorsion
. methods .
a rat testicular torsion model has been established as described .
rats were randomly divided into 6 groups : sham group , torsion group , torsion / detorsion ( t / d ) ... |
bleeding is a common complication of antithrombotic treatments of acute coronary syndrome ( acs ) , and invasive procedures are one of the important risk factors of bleeding.1)2 ) contrast media ( cm ) and heparin are used during coronary angiography ( cag ) and play a role as anticoagulants.3 ) the reported overall bl... | we report a patient who developed subarachnoid hemorrhage ( sah ) just after coronary angiography ( cag ) with non - ionic contrast media ( cm ) and minimal dose of heparin .
the 55-year - old man had a history of acute st elevation myocardial infarction that had been treated with primary percutaneous coronary interv... |
breast cancer is the most common cancer among women ( about one of every 3 cancers diagnosed ) in the united states , excluding cancers of the skin 1 . in 2008 in the united states , 182,460 new female breast cancer cases are estimated to occur and 40,480 are expected to die from this cause 2 . even though mortality ra... | objectives : breast cancer mortality is higher among african americans than for whites , though their breast cancer incidence is lower .
this study examines whether this disparity may be due to differential receipt of treatment defined as standard of care or
addition to standard of care by the national comprehen... |
they are seen in sun - exposed areas of the skin , usually in fairer skin types ( fitzpatrick types i iii ) . commonly occurring as a sign of photoageing
, they may also be seen in younger age groups , especially in those with fair skin .
the sites involved include , the nose and malar area ( most common sites ) ,... | aim : to study and compare the efficacy of tca ( 70% ) and phenol ( 80% ) in the treatment of freckles.settings and design : a prospective study was done , over one year , on patients having freckles on the face .
the freckles on the right side of the face were treated with tca ( 70% ) and those on the left side of t... |
manipulating the interactions between dc and nave t cells is an important part of the design of strategies for the immunotherapy of both solid and hematological cancers . in vitro
, dc can be generated from cd34 cells by culture with cytokines such as gm - csf , il-4 , flt3l , cd40 ligand , scf , and tgf-. alternativ... | most anti - cancer immunotherapeutic strategies involving dendritic cells ( dc ) as vaccines rely upon the adoptive transfer of dc loaded with exogenous tumour - peptides .
this study utilized human acute myeloid leukemia ( aml ) cells as progenitors from which functional dendritic - like antigen presenting cells ( d... |
a 12-year - old male presented with the chief complaint of a 1-month - history of decreased visual acuity in his right eye . at the time of admission , the best corrected visual acuity was 0.5 in the right eye and 1.0 in the left eye .
based on fundoscopy , the serous detachment had a well - defined margin of 1 disc ... | a 12-year - old male presented with a chief complaint of a 1-month - history of decreased visual acuity in his right eye .
the patient had no past history of steroid use or other systemic diseases .
on fundus examination , which included fluorescent angiography ( fag ) and optical coherence tomography ( oct ) , the... |
archwires are the most important parts of commonly used orthodontic appliances.1 the surface roughness of orthodontic arch wires is an essential factor in determining the effectiveness of archwire - guided tooth movement , corrosion behavior , surface contact and friction , biocompatibility , esthetics , hygiene , and ... | objectivethe purpose of this study was to evaluate the surface roughness ( sr ) of 2 types of orthodontic archwires made by 4 different manufacturers.methodsthis in vitro experimental study was conducted on 35 specimens of 7 different orthodontic archwires , namely , 1 nickel - titanium ( niti ) archwire each from the ... |
six men and four women aged between 20 and 45 years were selected for this study after getting approval from institutional ethics committee .
patients with oral submucous fibrosis falling in grades 3 and 4 were only selected for the study [ table 1 ] .
superiorly based platysma myocutaneous flap was raised as descr... | various surgical procedures are available for treating oral submucous fibrosis , but all of them have their inherent drawbacks .
the superiorly based platysma myocutaneous flap is a common reconstruction option for intraoral defects followed after excision of fibrous bands in oral submucous fibrosis .
the superiorl... |
the human placenta is unique among species . as a matter of fact , of all mammalian organs
the placenta shows the greatest variation in terms of anatomy . however , in all species it has the same fundamental function , to nourish the growing fetus , by establishing contact with the maternal blood circulation .
in a... | the human placenta is a difficult tissue to work with using proteomic technology since it contains large amounts of lipids and glycogen .
both lipids and glycogen are known to interfere with the first step in the two - dimensional polyacrylamide gel electrophoresis ( 2d - page ) , the isoelectric focusing . in order ... |
the federal government has begun implementing the prospective payment system , which is designed to improve the efficiency of hospital care for medicare patients . to achieve this goal
, the prospective payment system will pay hospitals a fixed payment rate for each category of illness based on the diagnosis - relate... | the medicare prospective payment system , which is based on the diagnosis - related group patient - classification system , identifies previously unrecognized redistributions of revenue among diagnosis - related groups and hospitals .
the redistributions are caused by two artifacts .
one artifact results from the u... |
pancreatic pseudocysts ( ppcs ) may develop in 10% to 20% of patients with acute pancreatitis and may be present in 20% to 40% of patients with chronic pancreatitis.1,2 during the last decade , the treatment strategies for ppcs have evolved dramatically in terms of indications , patient selection , and dedicated treatm... | during the last decade , great progress has been made in minimally invasive endoscopic techniques . for pancreatic pseudocysts ( ppcs ) ,
endoscopic drainage has become the first - line therapeutic option .
recent advances in therapeutic endoscopic ultrasound ( eus)-related techniques have focused on eus - guided t... |
in the setting of a competitive health care marketplace , factors influencing patient decisions concerning where to obtain medical services have been the focus of considerable study . some health care consumers may base their choice mainly on convenience rather than characteristics of care delivery,1 although hospital ... | backgroundthis investigation evaluated standardized process of care data collected on selected hospitals serving a remote rural section of westernmost north carolina.methodscenters for medicare and medicaid services data were analyzed retrospectively for multiple clinical parameters at fannin regional hospital , murphy... |
insulinoma is a rare pancreatic islet cell tumor with an estimated incidence of 0.4 per 100,000 person - years ( 1 ) .
the characteristic clinical manifestation of insulinoma is fasting hypoglycemia with neuroglycopenic symptoms including confusion , visual changes , and unusual behaviors ( 2 ) .
however , hypeinsu... | insulinoma is a rare , usually benign , pancreatic neuroendocrine tumor .
the clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior , while hypertension is usually not associated with the disease .
we herein report a patient with insulinom... |
patient satisfaction with care is a useful measure that evaluates care , including the quality of care and provider - patient relationships .
further , being considerate in dental care is a vital feature of the value of care and affects the future utilization of the facility .
therefore , it is necessary to access ... | aims and objectives : to evaluate the level of parents satisfaction with pediatric dental care provided by dental students at the college of dentistry and explore the factors associated with various parents demographics.materials and methods : a cross - sectional study was conducted among parents ( n = 150 ) whose chil... |
the two popular protein classification schemes , cath ( 1 ) and scop ( 2 ) , partition the protein structure universe hierarchically , proceeding from coarse - grained to fine - grained partitions .
the initial , coarse - grained partitioning of structure space is based on the secondary structure content . because th... | the fragnostic ( ) web tool implements a novel and useful view of protein structure space .
we mined a non - redundant subset of the pdb for common fragments shared between proteins inhabiting different scop folds .
subsequently , we formulated an inter - fold similarity measure based on fragment sharing .
fold s... |
clivo - cervical chordomas are locally destructive , invasive , slow - growing tumors that originate from the extra - axial remnants of the notochord
. definitive local resection can be curative ; however , these tumors are characterized by direct extension , local recurrence , and more rarely systemic and cerebrospi... | objective clival chordomas are slow - growing aggressive tumors that originate from the extra - axial remnants of the notochord .
current management of these tumors use surgical resection combined with radiation therapy . given the location and invasive nature of these tumors , complete resection is difficult . a va... |
pain , bleeding , infection , paresthesia , temporomandibular disorders , abscess formation , and dry socket have been known as common complications following extraction of impacted wisdom teeth [ 1 , 2 ] .
this syndrome is characterized by severe pain in the extraction and periextraction site accompanying by blood c... | background and purpose .
dry socket syndrome is one of the most irritating complications after tooth extraction .
this study aims to investigate the efficacy of pastille gecb compared to zoe .
materials and methods .
30 patients with dry socket syndrome were selected and divided into two groups .
gecb pastill... |
maintaining a patent airway becomes more essential when the surgery is being performed in the positions other than supine .
the situation would become a nightmare if inadvertent extubation occurs in prone position intraoperatively , and would require immediate intervention to maintain a patent airway .
there are an... | background : accidental extubation during surgery in prone position can be life - threatening .
supraglottic airway devices ( sad ) have been used successfully in such situations to rescue the airway . however , which sad would be most appropriate in this setting has not been described in the literature.aims:the aim ... |
sporothrix schenckii , the causative agent of sporotrichosis , is a relatively rare infection seen mainly in farmers , gardeners and carpenters .
infection usually occurs when either a contaminated thorn or a splinter directly inoculate the organism through the skin .
sporotrichosis is most frequently encountered a... | abstract
sporothrix schenckii , the causative agent of sporotrichosis , is a relatively rare infection .
local infection usually occurs through direct inoculation of the organism through the skin ; disseminated disease is rarely seen .
this article describes a case of disseminated sporotrichosis in a middle - age... |
homosexuality is rarely discussed publically as it is considered a taboo subject by both indian civil society and the government .
since the decriminalization of homosexual intercourse between consenting adults , there has been an increased acceptance of homosexuality and msms have come out more openly with their pro... | background : men who have sex with men ( msms ) are a vulnerable population for spread of sexually transmitted diseases ( stds ) and human immunodeficiency virus ( hiv ) .
apart from being important for hiv transmission , they tend to have a different distribution patterns of stds .
few indian studies have looked i... |
a patient was prescribed oyster shell calcium ( 500 mg / day ) with vitamin d3 ( 250 iu / day ) as supplement and developed parotid enlargement after two doses .
parotid gland may enlarge due to obstruction in parotid duct , inflammation , alcohol intake , diabetes mellitus , cancer , mumps and rheumatoid arthritis .... | a 59 year old female consumer was started on therapy with oyster shell calcium in combination with vitamin d3 and she presented with swelling below the ear , after two doses .
she stopped the drug by herself and the swelling disappeared in one day .
she started the drug one day after recovery and again she develope... |
spinal cord infarction ( sci ) is uncommon compared to cerebral stroke , but the outcome may be more disabling . due to its rarity , reliable estimates of incidence are scarce ; however , one study noted sci accounted for 1.2% of all strokes.1,2 sci due to occlusion of the anterior spinal artery , the principal vascula... | spinal cord infarction is uncommon and usually presents with sudden onset of paralysis and sensory disturbances .
a variety of causes are described , but rarely with multiple factors involved .
we report a case of a 63-year - old man with a history of diabetes mellitus , hypertension , and osteoarthritis who presen... |
about 1 million suicides occurred worldwide in the year 2000 . rate of suicide has shown an increasing trend over the last half century .
this results in about 20 million years of lost life , which means huge economic burden to society and families .
these have increased the need for attention of public health offi... | objective : to evaluate the possible interaction between religious beliefs and psychiatric disorders among black americans.methods:in this study , we used data of 5181 adult black americans who had participated in national survey of american life ( nsal ) from february 2001 to june 2003 .
variables such as socio - de... |
rheumatoid arthritis ( ra ) , a chronic and systemic inflammatory disease , can cause severe disability and increase the mortality rate because of deformed and painful joints .
previous studies have indicated an increased risk of cerebrovascular and neurodegenerative diseases and depression in patients with ra .
fu... | abstractrheumatoid arthritis ( ra ) , a chronic , systemic inflammatory disorder , primarily affects joints .
several studies have indicated that early inflammation , cardiovascular disease , and depression in patients were associated with a considerably increased risk of dementia .
nonsteroidal anti - inflammatory... |
mitosis is a highly
coordinated process , which is complex and dynamic
in nature .
errors in this process may
lead to the formation of cells with abnormal ploidy , a hallmark of
malignant cells .
understanding various biochemical
aspects of mitosis in cancer cells requires a systematic investigation
of ... | owing
to the dynamic and complex nature of mitosis , precise and
timely executions of biomolecular events are critical for high fidelity
cell division . in this context ,
visualization of such complex events
at the molecular level can provide vital information on the biomolecular
processes in abnormal cells... |
pathology , as with most medical specialties , is currently facing a growing demand to improve quality , patient safety and diagnostic accuracy because there is an increasing emphasis on sub - specialization .
these factors , coupled with economic pressures to consolidate and centralize diagnostic services , are driv... | objective : the purpose of this study was to assess the current status and future trends in telepathology ( tp ) and digital pathology ( dp ) in central india.materials and methods : a self - constructed questionnaire including 12 questions was designed with five specialists , to improve the design ambiguity .
the st... |
human immunodeficiency virus ( hiv ) has become a serious health , economic , and social problem with 35.3 million people living with hiv globally and 2.6 million people only in india till the year 2012 .
the first case of hiv in india was found in 1986 in a female sex worker of calcutta .
although the incidence of... | purpose : highly active antiretroviral therapy has significantly extended survival of human immunodeficiency virus ( hiv ) infected patients .
these drugs suppress replication of hiv but at the same time , have many physical and mental side effects which may affect daily activities of the patients .
the present stu... |
a clinic ( either an out - patient clinic or an ambulatory care clinic ) is a health care facility that is primarily devoted to the care of patients .
clinics can be privately operated or publicly managed and funded , and typically cover the primary health care needs of populations in local communities .
the out - ... | the out - patient renal clinic ( orc ) represents an important part of the nephrology service in general hospitals .
the majority of renal diseases are chronic and patients need a systematic follow - up according to the severity and progression of kidney failure .
the most important clinical manifestation is chroni... |
cellular therapy has been an area of intense research over few decades , which is widely used for treatment of cardiovascular disease .
bone - marrow - derived mesenchymal stem cells ( bm - mscs ) were isolated from adult bone marrow , along with the ability for self - renewal and multilineage differentiation into ca... | bone - marrow - derived mesenchymal stem cells ( bm - mscs ) were found to markedly increase atherosclerotic lesion size .
the aim of this paper was to investigate whether bm - mscs contribute to vascular remodeling and calcification after balloon injury in hyperlipidemic rats .
labeled bm - mscs were found in the ... |
sarcoidosis is defined as a multisystem granulomatous disorder of unknown cause .
venous thrombosis ( vt ) in the sarcoidosis is rare .
the routine use of 18f - fluorodeoxyglucose positron emission tomography / computed tomography ( 18f - fdg pet / ct ) has resulted in clinicians detecting many incidental findings ... | |
the uremic state is associated with an altered immune response ( 2 ) and intermittent stimulation by endotoxins from the dialysis water supply and artificial vein grafts or bio incompatibility caused the increased inflammatory proteins , such as c - reactive protein ( crp ) ( 3 ) .
in addition to inflammatory marker ... | background : inflammatory and procoagulant markers are potential mediators for the cardiovascular risk in hemodialysis patients . lipoprotein ( a ) [ lp(a ) ] , is another important risk factor with inflammatory and procoagulant effects.materials and methods : in 78 hemodialysis patients and 40 controls , c - reactive ... |
a phacoantigenic reaction to sequestered lens protein usually occurs following capsular rupture or dehiscence , secondary to trauma or surgery .
straub was the first to suggest that liberated lens proteins could incite a reaction within the eye .
verhoeff and lemoine further refined this concept and coined the term... | a 72-year - old phakic male with immature cataract underwent vitrectomy with silicone oil injection in his left eye for rhegmatogenous retinal detachment .
the surgery was uneventful except for lens touch during vitrectomy .
two weeks postoperatively , he presented with circumcorneal congestion , hypopyon , and abs... |
the online version of this article ( doi:10.1007/s12348 - 012 - 0078 - 6 ) contains supplementary material , which is available to authorized users .
video 1video showing the surgical removal of the worm ( mpg 9,945 kb ) video showing the surgical removal of the worm ( mpg 9,945 kb )
this article is distributed u... | we describe a case of subconjunctival dirofilariasis from south india .
the worm was identified by detailed morphologic study.electronic supplementary materialthe online version of this article ( doi:10.1007/s12348 - 012 - 0078 - 6 ) contains supplementary material , which is available to authorized users . |
healthy humans maintain blood glucose within relatively tight limits , a feat of homeostasis that is particularly remarkable considering the wide variations in the amount and timing of carbohydrate intake .
an essential feature of the maintenance of glucose tolerance is the ability of the endocrine pancreas to rapidl... | abstractglucagonlike peptide1 ( glp1 ) is a product of proglucagon cleavage synthesized in l cells in the intestinal mucosa , cells in the pancreatic islet , and neurons in the nucleus of the solitary tract .
glp1 is essential for normal glucose tolerance and acts through a specific glp1 receptor that is expressed b... |
at its heart there are essentially only two categories of stem cells : the embryonic stem cell ( es cell ) and the postnatal stem cell ( i.e. , adult stem cell ) . the es cell , as its name implies , is derived from the embryo more specifically , from the blastocyst 's inner cell mass . the adult stem cell , in contra... | in 2002 , researchers at ucla published a manuscript in molecular biology of the cell describing a novel adult stem cell population isolated from adipose tissue the adipose - derived stem cell ( asc ) .
since that time , the asc has gone on to be one of the most popular adult stem cell populations currently being us... |
large - scale comparison of complete microbial genomes reveals that numerous gene clusters are conserved across species ; i.e. sets of genes occur in the same physical arrangement in two or more species .
such gene clusters often , but not always , represent co - transcribed units , or operons , which are sets of gen... | the fast pace of bacterial genome sequencing and the resulting dependence on highly automated annotation methods has driven the development of many genome - wide analysis tools .
operondb , first released in 2001 , is a database containing the results of a computational algorithm for locating operon structures in mic... |
the hypothalamus has long been known to play an important role in feeding behavior . as far back as 1951 , anand and brobeck reported that bilateral destruction of the lateral hypothalamus ( lh ) in rats resulted in the complete absence of eating , leading them to term this area of the brain the feeding center . sh... | transcribed within the lateral hypothalamus , the neuropeptides orexin / hypocretin ( ox ) and melanin - concentrating hormone ( mch ) both promote palatable food intake and are stimulated by palatable food . while these two neuropeptides share this similar positive relationship with food , recent evidence suggests tha... |
technetium-99 m
is widely used in over 90% of all current diagnostic nuclear medicinal applications [ 15 ]
due to its favourable nuclear properties ( t1/2 = 6.02 hours ,
y = 140 kev 100% ) and availability from a generator .
it is routinely used for brain , heart , liver , kidney , and bone imaging .
technet... | a kinetic study of the aqua substitution in the [ tco(oh2)(cn)4] complex by different thiourea ligands ( tu = thiourea , nmtu = n - methyl thiourea , nndmtu = n , n-dimethylthiourea ) yielded second - order formation rate constants ( 25c ) as follows [ nndmtu , nmtu , tu , respectively ] : kf = 11.5 0.1 , 11.38 0.0... |
male health professionals age 4075 years at baseline in 1986 who returned a mailed questionnaire about diet and medical history .
we also excluded men who had implausible nutritional information ( 70 missing food items or estimated daily energy intake < 800 or > 4,200 kcal ) .
furthermore , we excluded men who had ... | objectivethe objective of this study was to investigate the association of 4-year changes in alcohol consumption with a subsequent risk of type 2 diabetes.research design and methodswe prospectively examined 38,031 men from the health professionals follow - up study who were free of diagnosed diabetes or cancer in 1990... |
a sixty - year - old man was admitted to the emergency department with sharp , stabbing chest pain .
the symptom had first appeared a month ago , and had aggravated in the 5 days prior to presentation .
the patient 's medical history showed that he had undergone a fixation operation using kirschner wire for treatme... | a sixty - year - old man was admitted due to chest pain . he had a history of pelvic bone fracture fixation with kirschner wire about 20 years earlier . on examination
, we detected a kirschner wire that had migrated into the right ventricle . without cardiopulmonary bypass
, we removed the migrating kirschner wire... |
multisite coordinated production systems are the common method of swine production in the united states .
these systems consist of multiple farms operating in tandem , with each farm responsible for 1 stage of the production process ( figure 1 ) .
these systems are closed , meaning there are no introductions of ani... | to clarify the epidemiology of influenza a viruses in coordinated swine production systems to which no animals from outside the system are introduced , we conducted virologic surveillance during september 2012september 2013 . animal age , geographic location , and farm type were found to affect the prevalence of these ... |
ovarian cancer is the fifth leading cause of cancer - related deaths among women , and the most lethal of the gynecological cancers.1 the high mortality rate in patients with ovarian cancer is primarily attributable to late diagnosis , when metastases have already formed , and to development of chemoresistant clones th... | background and methodsnanoparticles engineered to carry both a chemotherapeutic drug and a sensitive imaging probe are valid tools for early detection of cancer cells and to monitor the cytotoxic effects of anticancer treatment simultaneously .
here we report on the effect of size ( 1030 nm versus 50 nm ) , type of m... |
sequence analysis of mirna positions in the human genome reveals the majority of mirnas are located in intergenic regions , , although a few located within exonic or intronic regions have been described .
the canonical pathway for mirna biogenesis begins with transcription of primary mirna ( pri - mirna ) by rna poly... | in recent years , it has become increasingly apparent that noncoding rnas ( ncrna ) are of crucial importance for human cancer .
the functional relevance of ncrnas is particularly evident for micrornas ( mirnas ) and long noncoding rnas ( lncrnas ) .
mirnas are endogenously expressed small rna sequences that act as... |
cerebral palsy ( cp ) is a disorder of movement and posture that appears during infancy or
early childhood .
it is caused by non - progressive damage to the developing brain before ,
during , or shortly after birth .
spastic cp is the most common form of cp ( accounting for
approximately 7080% of cases of cp ... | [ purpose ] the purpose of this study was to determine whether strength training programs
for hip extensors and knee extensors improve gross motor function of children with
cerebral palsy in myanmar .
[ subjects and methods ] forty children ( 25 boys and 15 girls ,
mean age : 6.07 2.74 years ) from national r... |
type 2 diabetes ( t2d ) is a complicated and chronic metabolic disease characterized by insulin resistance and pancreatic - cell dysfunction ( 1 ) .
, many t2d susceptibility genes were identified ( 213 ) due to the completion of the hapmap project , an international collaborative effort to help researchers identify... | abstractbackgroundthere are much heterogeneity in the genetic variation of type 2 diabetes ( t2d ) .
the purpose of this study was to investigate the association of seven novel genetic loci identified in a recent genome - wide association studies ( gwas ) with t2d in chinese dong populations.methodsa case - controlle... |
loss of posterior teeth may result in loss of neuromuscular stability of the mandible , reduced masticatory efficiency , loss of vertical dimension of occlusion and attrition of the anterior teeth.1 kennedy classified those patients suffering from bilateral missing posterior teeth as kennedy class i removable partial d... | background : this study was conducted to compare and evaluate the effect of two different attachments ( locator attachment and ball and socket [ b&s ] attachment ) on implants and natural abutments supporting structures , in cases of limited inter - arch spaces in mandibular kennedy class i implant supported removable ... |
gpr39 is a member of the ghrelin receptor family , all of which are peptide receptors described to be involved in the peripheral and/or central control of appetite , gi tract function , energy homeostasis , and metabolism [ 15 ] .
the gpr39 locus is rather complex with an overlapping antisense gene lypd1 and the occu... | mice deficient in the zinc - sensor gpr39 , which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro , display moderate glucose intolerance and impaired glucose - induced insulin secretion . here
, we use the tet - on system under the control of the proinsulin promoter to sele... |
type 2 diabetes mellitus ( t2 dm ) has two major characteristics : reduced insulin sensitivity linked to obesity and impaired insulin secretion due to -cell dysfunction .
-cell dysfunction occurs when the demand for insulin finally overwhelms the capacity of the -cell to respond , which results in severely reduced in... | glucagon like peptide-1 ( glp-1 ) receptor agonists such as exendin-4 have been widely used but their short half - life limits their therapeutic value . the recombinant protein , e2hsa , is a novel , long - acting glp-1 receptor agonist generated by the fusion of exendin-4 with human serum albumin . in mouse pancreatic... |
a diffuse interstitial infiltrative pattern is rare and can be misdiagnosed as more commonly accompanying conditions including pulmonary edema or drug - induced pneumonitis .
we experienced a 37-year - old man with diffuse interstitial infiltrative lung metastasis of malignant melanoma and report findings of computed... | a diffuse interstitial infiltrative pattern of lung metastasis in a patient with malignant melanoma is rare and can be confused with benign conditions such as pulmonary edema or drug - induced pneumonitis .
we experienced a case of diffuse interstitial infiltrative lung metastasis in malignant melanoma in a 37-year -... |
the protozoan parasite toxoplasma gondii ( t. gondii ) which causes toxoplasmosis , is primarily hosted not only in cats but also in mice , rabbits , dogs , farmyard and wild animals , and domestic fowl , and is transmissible to man [ 15 ] .
it has been implicated in the pathogenesis of many diseases , most notably s... | toxoplasma gondii is not only implicated in schizophrenia and related disorders , but also in alzheimer 's or parkinson 's disease , cancer , cardiac myopathies , and autoimmune disorders . during its life cycle
, the pathogen interacts with ~3000 host genes or proteins .
susceptibility genes for multiple sclerosis... |
a biomarker used in a clinical trial can be prognostic or predictive , and it is important to distinguish between these two types of biomarkers .
a prognostic biomarker is associated with how well patients will do with a given treatment .
predictive biomarkers tend to be more useful because they can improve outcome... | on february 2 , 2012 , the national cancer institute ( nci ) sponsored a 2-day workshop with the nci thoracic malignancies steering committee and the food and drug administration to bring together leading academicians , clinicians , industry and government representatives to identify challenges and potential solutions ... |
juvenile hyaline fibromatosis ( jhf ) is a rare , autosomal - recessive hereditary disease with distinct clinical and histopathological features .
a scan of the world literature revealed that less than 70 cases have been reported so far.[13 ] the clinical onset is usually noted from birth up to 5 years of age .
it ... | juvenile hyaline fibromatosis is a rare , autosomal - recessive disease characterized by papular and nodular skin lesions , gingival hyperplasia , joint contractures and bone involvement in variable degrees .
it is a connective tissue disorder with aberrant synthesis of glycosaminoglycans by fibroblasts .
we report... |
hospital supply systems should ensure adequate stock of all the required items to maintain uninterrupted supply .
advances in medical care and drugs have disproportionately increased the expenditure on health care delivery .
therefore , about one - third of the hospital budget is spent on purchasing various materia... | economic analysis plays a pivotal role in the management of medical store .
the main objectives of this study were to consider always better control - vital , essential and desirable ( abc - ved ) analysis with economic order quantity ( eoq ) , comparison of indexed cost and the actual cost , and to assess the expend... |
listeria monocytogenes can rarely infect atherosclerotic abdominal aortic aneurysms ( aaa ) in nonimmunocompromised patients .
in contrast to listerial meningitis and bacteraemia , where over 90% of patients have immunosuppression due to neoplasia or other reasons , it has been suggested that patients with listerial ... | a rare case of an abdominal aortic aneurysm ( aaa ) infected by listeria monocytogenes in a 72-year - old male diabetic farmer , is reported .
our patient had a history of a recent pneumonia that could have been caused by listeria too .
aneurysm infection was manifested by fever and abdominal and back pain , which ... |
the catalytic functionalization
of aldehyde c h bonds represents
a mild and atom - economical approach to prepare esters . while there has been much progress in developing hydroacylation
of aldehydes , the hydroacylation of ketones is relatively unexplored and warrants
attention due to its potential for constr... | under rh(i ) catalysis ,
-ketoamides undergo intermolecular
hydroacylation with aliphatic aldehydes . a newly designed josiphos
ligand enables access to -acyloxyamides with high atom - economy
and enantioselectivity . on the basis of mechanistic and kinetic
studies ,
we propose a pathway in which rhodium pl... |
in recent years , there has been an increase in the incidence of invasive candidiasis ( ic ) and a shift toward non - albicans candida species , some of them resistant to fluconazole . despite advances in the diagnostic and therapeutic management ,
the crude mortality associated with ic is as high as 40 - 50% . among... | candida norvegensis is an emerging fluconazole - resistant pathogen isolated in most cases from skin and mucous membranes of immunocompromized patients .
documented invasive candidiasis ( ic ) due to c. norvegensis has been rarely reported , thus the clinical features of patients at risk for this pathogen are poorly ... |
exercise facilitates metabolic functions in the human body and benefits physical health by
preventing disease , controlling weight , and maintaining homeostasis1 .
the american heart association reported that a lack of
exercise is one of the main factors of heart disease ( along with high blood pressure ,
hyper... | [ purpose ] the purpose of this study was to investigate the effects of exercise on
myocardial injury in male sprague - dawley rats .
two groups of rats were trained with either
moderate- or high - intensity treadmill running for four weeks .
subsequently , the
concentrations of cardiac troponin and the n - t... |
semiconductors usually exhibit quantum size effects and electric and optical properties different from bulk materials , when their particle size decreases to nanometer scale .
the fabrication strategy for semiconductor nanostructure includes a wide variety of vapor , liquid , and solid state processing routes .
dif... | the two - solvent method was employed to prepare zno encapsulated in mesoporous silica ( zno / sba-15 ) .
the prepared zno / sba-15 samples have been studied by x - ray diffraction , transmission electron microscope , x - ray photoelectron spectroscopy , nitrogen adsorption desorption isotherm , and photoluminescenc... |
prepregnancy obesity is associated with adverse pregnancy and birth outcomes , including increased risk of gestational diabetes , preeclampsia , caesarean section , and having a large - for - gestational - age neonate [ 1 , 2 ] .
prepregnancy obesity rates in the us are high , affecting approximately 1 in 5 pregnanci... | introduction .
menarche is a critical time point in a woman 's reproductive system development ; exposures at menarche may influence maternal health . living in a poorer neighborhood
is associated with adult obesity ; however , little is known if neighborhood factors at menarche are associated with prepregnancy obe... |
a 33-year - old man with ebstein anomaly and klinefelter syndrome was referred to severance cardiovascular hospital for the surgical treatment of severe tricuspid regurgitation ( tr ) .
the patient underwent surgical repair of carpentier type b ebstein anomaly when he was nine years old using the danielson technique ... | the management of recurrent tricuspid regurgitation after tricuspid valve repair in patients with ebstein anomaly is difficult , and tricuspid valve replacement is most commonly performed in such patients .
we report two cases of recurrent tricuspid regurgitation in patients with ebstein anomaly that were successfull... |
tourette syndrome is a neurodevelopmental disorder that is characterized by both multiple motor and one or more vocal tics present some time during the illness with onset before 18 years . a large majority of the patients with gilles de la tourette syndrome are known to have psychiatric comorbidities with attention - d... | tourette syndrome and bipolar disorder are frequent comorbidities in pediatric age group .
they provide a clinician with certain unique challenges . while on one hand the tics mask manifestation of affective symptomatology , the latter makes it difficult to elicit tics with certainty .
data suggest that they might ... |
advances in genetic epidemiology have revealed that some genetic variants increase the risk for is .
evidence suggests that genetic variation in the rennin angiotensin - aldosterone system ( raas ) contributes to the risk of ischemic stroke . among the various sequence variations in raas ,
the insertion / deletion ... | the possible association of ace polymorphism with ischemic stroke ( is ) was evaluated in 65 patients with is and 330 age and bmi - matched controls .
ace genotypes were determined by polymerase chain reaction ( pcr ) .
there was no significant difference in ace genotype / allele frequencies between case and contro... |
neuroendocrine tumor ( net ) is a relatively rare tumor with predominant neuroendocrine differentiation and it is found in most organs of the body ( 1 ) .
most nets are located in the gastrointestinal tract , pancreas , and bronchopulmonary system ( 2 ) .
well - differentiated nets were originally classified as car... | rectal neuroendocrine tumor ( net ) is a relatively rare tumor .
net is classified as g1 , g2 , or g3 according to the degree of mitosis or ki-67 proliferation index , which reflect the malignant potential of the tumor , such as metastasis .
advanced cases with metastasis are indicated for chemotherapy treatment . ... |
an ideal endodontic material should be bio - compatible , radiopaque , antibacterial , dimensionally stable and easy to manipulate
. it should be able to adhere to the root - end cavity walls and remain in place under dislocating forces ( i.e. mechanical stresses caused by tooth function or operative procedures ) [ 1... | objective : the aim of this study was to compare the effect of an acidic environment on dislocation resistance ( push - out bond strength ) of endosequence root repair material ( errm putty and errm paste ) , a new bioceramic - based material , to that of mineral tri - oxide aggregate ( mta).materials and methods : one... |
sepsis is a systemic disease characterized by microbial infection and systemic inflammatory response syndrome ( sirs ) , which has high morbidity and mortality rates in intensive care units ( icus ) .
the exacerbation of sepsis is always accompanied by the dysfunction of the innate and adaptive immune responses [ 2 ,... | microrna-146a ( mir-146a ) acts as a pivotal regulatory molecule in immune response and various diseases , such as carcinoma and autoimmune diseases .
growing evidences have demonstrated the association of mir-146a gene single - nucleotide polymorphisms ( snps ) with risk of several diseases , but no genetic relevanc... |
a 56-year - old male with a history of deep vein thrombosis located in left common iliac vein and hypertension underwent thromboembolectomy in july 2015 .
contrast - enhanced computed tomography ( ct ) scan revealed a renal cyst with internal enhancing structure in the upper pole of the right kidney , which measured ... | granulomatous reaction associated with clear cell renal cell carcinoma ( ccrcc ) is a rare finding , and only a few cases have been described in the literature .
it is postulated to occur due to cancer - related antigenic factors such as cancer cells themselves or soluble tumor antigens shed into the blood .
herein... |
counties with a high incidence of lyme disease were identified by using satscan version 9.1.1(4 ) .
numbers of confirmed lyme disease cases reported at the county level during 19932012 were aggregated into 5-year intervals ( 19931997 , 19982002 , 20032007 , 20082012 ) to minimize the influence of travel - associated ... | lyme disease occurs in specific geographic regions of the united states .
we present a method for defining high - risk counties based on observed versus expected number of reported human lyme disease cases . applying this method to successive periods shows substantial geographic expansion of counties at high risk for... |
computational
drug discovery efforts are generally focused on calculation
of equilibrium protein ligand binding affinities .
there is
no question that the equilibrium binding affinity is an important
predictor of ligand efficacy , and achieving adequate values of this
quantity is a necessary ( although not... | computer
simulations are used to determine the free energy landscape
for the binding of the anticancer drug dasatinib to its src kinase
receptor and show that before settling into a free energy basin the
ligand must surmount a free energy barrier . an analysis based on using
both the ligand - pocket separatio... |
marijiuna is the most widely used illicit drug in the united states and , marijiuana smoking is rapidly increasing in europe and in some regions of turkey.1)2 ) it is well known that marijiuana has several well - defined effects , such as irregularity of heart rate or blood pressure , vasospasm , vasodilation , and alt... | marijuana is known to have been used for medicinal and recreational purposes for thousands of years .
although marijuana has some diverse effects on cardiovascular system , there is insufficient knowledge concerning acute myocardial infarction ( ami ) associated with marijuana and its underlying mechanism .
we repo... |
through the use of chemical probes , chemical genetics allows elucidation of the biological role and therapeutic significance of proteins [ 1 , 2 ] .
chemical genetics is similar to classical genetics ( knock - outs , mutations , knock - downs ) , but alters a different point in the gene protein
classical genetics... | graphical abstractin conventional chemical genetics , cell - active small - molecules directly block protein activity , altering phenotype .
however these molecules may not be sufficiently selective or effective at modulating complex epigenetic pathways . by mutating the target protein , and creating a mutant - selec... |
apart from the impact of leishmania on world health , leishmaniasis represents an elegant infection model that can teach us a lot about host - parasite interactions and immune evasion .
this parasite has the ability to enter host macrophages ( ms ) safely and replicate inside the very same phagocytes that were recrui... | leishmania parasites are able to secure their survival and propagation within their host by altering signalling pathways involved in the ability of macrophages to kill pathogens or to engage adaptive immune system .
an important step in this immune evasion process is the activation of host protein tyrosine phosphatas... |
opioids are potent analgesics that are often necessary for treating moderate to severe pain . however , experimental studies report that opioids may also elicit hyperalgesia and allodynia 1 .
it is , therefore , likely that tolerance develops more rapidly with a rapid offset drug such as remifentanil than with longer... | background : the aim of this prospective , randomized , placebo - controlled study was to compare the effects of ketamine and paracetamol on preventing remifentanil induced hyperalgesia.methods : ninety patients undergoing total abdominal hysterectomy were randomly assigned to one of three groups to receive ( i ) eithe... |
the principal role of hospital pharmacists in japan has changed from drug compounding works
for outpatients to total inpatient care as a member of the medical team1 , 2 .
drug compounding
and filling of prescriptions for outpatients have been transferred to dispensing pharmacists
in community pharamacies3 .
w... | in japan , the principal role of hospital pharmacists has changed from that of
dispensing medicines for outpatients to provision of clinical pharmacy services for
inpatients . a self - administered questionnaire about subjective symptoms , working patterns ,
work environments and job satisfaction was administered... |
wikipedia defines personalized medicine as the " use of information and data from a patient 's genotype , or level of gene expression to stratify disease , select a medication , provide a therapy , or initiate a preventative measure that is particularly suited to that patient at the time of administration . "
a mor... | personalized medicine is typically described as the use of molecular or genetic characteristics to customize therapy .
this perspective at best provides an incomplete model of the patient and at worst can lead to grossly inappropriate practices .
personalization of medicine requires two characterizations : a well -... |
with advancement in trauma care , the evaluation and management of vascular injuries of neck are of primary concern as they cause significant mortality . clinical examination along with computed tomography ( ct ) angiography plays a major role in assessment of vascular injury in neck.2 , 3 vascular injuries are managed... | neck , being not protected by skeleton , is vulnerable to external trauma and injury which involves blood vessels , trachea , esophagus and other endocrine and nervous system organs .
vascular injuries can not only cause potentially life - threatening hemorrhage but also need profound surgical expertise in management... |
recent data suggest that mean birth weight has increased over time in many developed nations [ 1 , 2 ] .
birth weight shows a u shaped relationship with adult obesity , such that both small and large babies are at increased risk [ 3 , 4 ] .
the long - term effects of higher body fat at birth are now attra... | background / aim . dietary glycemic index ( gi ) has received considerable research interest over the past 25 years although its application to pregnancy outcomes is more recent .
this paper critically evaluates the current evidence regarding the effect of dietary gi on maternal and fetal nutrition .
methods .
a ... |
irritable bowel syndrome ( ibs ) is one of the most common cases referred to a general practitioner and consultation with gastroenterologists .
based on the rome ii criteria , 10%20% of people in different communities have ibs , which is two times more common in women .
celiac disease ( cd ) has many symptoms which... | background : the prevalence of irritable bowel syndrome ( ibs ) in the community is 10%20% and have symptom based diagnostic criteria
. many symptoms of celiac disease ( cd ) with 1% prevalence in some communities can mimic ibs .
sensitive and specific serologic tests of cd can detect asymptomatic cases .
the pur... |
eosinophilic granuloma ( eg ) is the benign form of three clinical variants of langerhans cell histiocytosis ( lch ) .
the other two variants are letterer - siwe disease and hand - schller - christian disease .
the term , eosinophilic granuloma was first introduced by lichtenstein and jaffe in 1940 .
eg is char... | eosinophilic granuloma is a variety of histiocytosis - x with unknown etiology .
eosinophilic granuloma occurs as single or multiple lesions of bone destruction .
it is seen more commonly in children or young adults although it may be found at all ages .
other sites like the lung and the gastrointestinal tract ma... |
a 70-year - old man ( 155 cm and 52.7 kg ) presented with progressive dysphagia underwent an endoscopic examination and was diagnosed with esophageal cancer .
he did not have a prior medical history of diabetes or hypertension but he had undergone esophageal stent insertion one month earlier due to an esophageal stri... | the breakage of an epidural catheter is a rare complication during the removal of a thoracic epidural catheter .
there are many causes to breakage of an epidural catheter , such as the characteristics of the catheter itself , patient 's factors ( anatomy , position during insertion and removal of the catheter , and t... |
idiopathic scoliosis is a three - dimensional spine deformity that frequently occurs during
adolescence ( adolescent idiopathic scoliosis : ais ) ; however , its aetiology remains unclear
and is probably multifactorial1 .
kuo et
al.2 showed that patients with ais
demonstrate asymmetric muscle activation durin... | [ purpose ] the objective of the study was to evaluate the symmetry of the thickness of the
abdominal muscles at rest and while standing in patients with adolescent idiopathic
scoliosis . [ subjects and methods ] an ultrasound assessment was performed of the
side - to - side differences of the external oblique ( ... |
despite the enormous investment in critical care resources , severe sepsis mortality ranges from 28% to 50% or greater .
moreover , cases of severe sepsis are expected to rise in the future for several reasons , including : increased awareness and sensitivity for the diagnosis ; increasing numbers of immunocompromise... | background : early diagnosis and appropriate therapy of sepsis is a daily challenge in intensive care units ( icus ) despite the advances in critical care medicine . procalcitonin ( pct ) ; an innovative laboratory marker , has been recently proven valuable worldwide in this regard.objectives:this study was undertaken ... |
pain can be produced by activation of the nociceptive pathways following damage to tissues , or by damage to nerves ( 1 ) .
neuropathic pain is defined by the international association for the study of pain ( iasp ) as pain that arises as a direct consequence of a lesion or disease affecting the somatosensory system ... | objective(s):neurotrophins ( nts ) exert various effects on neuronal system .
growing evidence indicates that nts are involved in the pathophysiology of neuropathic pain .
however , the exact role of these proteins in modulating nociceptive signaling requires being defined .
thus , the aim of this study was to ev... |
knee dislocation is a complex trauma often characterized by association of several capsulo - ligamentous lesions ; its treatment remains controversial . for rational planning and treatment , it is important to define exactly the degree of dislocation and the complexity of the associated lesions .
various scales have ... | irreducibility of the knee following complete dislocation is a rare event determined by the interposition of various capsulo - ligamentous structures in the joint space .
such cases often require urgent surgical treatment .
we report the case of a healthy 70-year - old man with a sprain of the left knee that occurr... |
an 82-year - old man presented at our institution with a chief complaint of an abdominal mass and associated abdominal discomfort .
he had first noticed it 4 years before the consultation , and it was revealed as a lipomatous retroperitoneal tumor by computed tomography ( ct ) performed at a local clinic .
the clin... | retroperitoneal liposarcoma is an infrequent , locally aggressive malignancy .
we report two cases of huge retroperitoneal liposarcomas .
the presence of a palpable abdominal mass was a common symptom of the two patients .
preoperative imaging study showed huge retroperitoneal tumors .
both patients underwent c... |
being highly accessible and facilitating simultaneous doppler signal and b - mode image , ultrasonography enabled an unique , non - invasive , imaging method of the portal system .
the primary studies on this technique investigated blood flow in the portal veins and its tributaries quantitatively . using this data , ... | we report a case of a 17-year - old patient referred to our outpatient doppler department due to clinical suspicion of liver cirrhosis .
the patient presented with non - specific symptoms , such as malaise , pain in the right subcostal region , peripheral oedema . until then , diagnostic imaging , including echocardi... |
enzyme - catalyzed reactions organized into sequential pathways are responsible for producing the molecules needed to sustain life .
while many essential metabolic pathways are present in all known life forms , there are also significant differences between microbial and mammalian metabolism .
most microbial specie... | the aspartate pathway of amino acid biosynthesis is essential for all microbial life but is absent in mammals .
characterizing the enzyme - catalyzed reactions in this pathway can identify new protein targets for the development of antibiotics with unique modes of action .
the enzyme aspartate -semialdehyde dehydro... |
visual loss in cryptococcal meningitis may occur from chronically elevated intracranial pressure , adhesive arachnoiditis , or direct invasion of the visual sensory pathway by the organism ( kupfer and mccrane 1974 ; ofner and baker 1987 ; tan 1988 ; lipson et al 1989 ; garrity et al 1993 ) .
medical therapy with ant... | a patient with acquired immunodeficiency syndrome ( aids ) developed crytpococcal meningitis , complicated by papilledema and severe progressive visual loss despite medical therapy .
bilateral optic sheath fenestration resulted in significant improvement in vision and resolution of papilledema .
histopathologic eva... |
the reca gene was first identified in escherichia coli more than 40 years ago , and hundreds ( if not thousands ) of papers have shown this gene to be centrally important to both the recombination and repair of dna . while genetic recombination helps create genetic diversity and therefore increases the fitness of a pop... | the reca protein has been the most intensively studied protein involved in homologous genetic recombination , but until recently very little has been known about the molecular details of how reca can bring two dna molecules into juxtaposition and switch strands between them .
a recent reca - dna crystal structure pro... |
age estimation of has to be done in both living and dead individual 's for legal procedures , to identify victims during mass disasters , and for anthropological studies . in deceased individual 's age estimation ; post - mortem environment can modify the body parts and render estimation difficult .
when different pa... | objective : to develop an independent procedure for estimating age for indian individuals using radiographs of multi - rooted posterior teeth with accuracy needed in forensic age prediction.materials and methods : orthopantomography ( opg ) was obtained for 88 subjects .
the subjects were divided into two sub sets ; ... |
craniofacial fibrous dysplasia ( fd ) is a bone development anomaly characterized by hamartoma proliferation of fibrous tissue within the medullary bone , with secondary bony metaplasia , producing immature , newly formed and weakly calcified bone without maturation of osteoblast which appears on radiographs as a radio... | craniofacial fibrous dysplasia ( fd ) is one of three types of fd which can affect the craniofacial complex .
it is the proliferation of cellular fibrous connective tissue intermixed with irregular bony trabecules .
it is a developmental tumor - like condition that is characterized by replacement of normal bone .
... |
concerns about the integrity of the research enterprise have been raised for many years ( e.g. , 7 , 8 , 13 , 18 ) .
one proposed remedy has been to promote training of new scientists in responsible conduct of research ( rcr ) .
this has been tried now for approximately 25 years ( 14 , 23 ) , beginning with a natio... | requirements for training in responsible conduct of research have significantly increased over the past 25 years , but worries about the integrity of science have only intensified .
the approach to training has relied largely on short - term experiences , either online or in person .
even if done well , such strate... |
long - term hyperglycemia not only significantly impairs the microstructure of the kidney , leading to diabetic nephropathy ( dn ) , but also causes renal artery stenosis ( ras ) in diabetic patients [ 1 , 2 ] . the ras detection rate in type 2 diabetes patients was recently reported to be 36.9% using duplex ultrasound... | objective .
revascularization of aortorenal bypass is a preferred technique for renal artery stenosis ( ras ) in diabetic nephropathy ( dn ) patients .
restenosis of graft vessels also should be considered in patients lacking good control of blood glucose . in this study
, we explored a combined strategy to preve... |
primary renal squamous cell carcinoma ( scc ) constitutes less than 1% of all urinary tract neoplasms .
renal scc is more frequently reported in the urinary bladder and male urethra than in the renal pelvis .
although this malignancy is rare in the upper urinary tracts , this diagnosis should be included in the dif... | squamous cell carcinoma ( scc ) of the renal pelvis is a rare neoplasm and is usually associated with long standing renal stone disease .
this tumor is aggressive in nature and usually has a poor prognosis .
we report a case who presented with sudden significant weight loss . during the radiologic investigation ,
... |
insomnia , in terms of a diagnostic entity , is defined as having difficulties to fall asleep or to maintain sleep during the night , or early morning wakening and consequently experiencing impairments in daytime functioning for at least 4 weeks .
consequently , patients worry and ruminate about their symptoms at nig... | insomnia is the most prevalent sleep disorder worldwide .
a number of studies evaluated the efficacy of pharmacological and nonpharmacological treatment approaches . to obtain long - term effects in the management of chronic insomnia , cognitive - behavioral therapy for insomnia ( cbt - i ) is the treatment of first ... |
spillage of bile and gallstones due to accidental perforation of the gallbladder wall is often encountered during laparoscopic cholecystectomy .
although spilled stones were once considered harmless , there is increasing evidence that they can result in septic or other potential complications .
we report a case of ... | background : spillage of bile and gallstones due to accidental perforation of the gallbladder wall is often encountered during laparoscopic cholecystectomy .
although spilled stones were once considered harmless , there is increasing evidence that they can result in septic or other potential complications.case report... |
progressive outer retinal necrosis ( porn ) is a rare but devastating infectious retinitis associated with varicella zoster virus ( vzv ) and responsible for severe visual loss .
a 59-year - old man treated for generalized myasthenia with oral azathioprine and prednisone presented with severe unilateral necrotizing r... | introductionprogressive outer retinal necrosis ( porn ) is a rare but devastating infectious retinitis associated with varicella zoster virus ( vzv ) and responsible for severe visual loss.case reporta 59-year - old man treated for generalized myasthenia with oral azathioprine and prednisone presented with severe unila... |
cancer is the second
leading cause of death in the united states
after heart disease , yet a cure for this
disease remains elusive .
soybean isoflavones have been shown to exhibit
anticancer and antiproliferative activity toward cancerous cells .
much of the health - related research concerning soy - derive... | glyceollin - related
metabolites produced in rats following oral
glyceollin administration were screened in plasma , feces , and urine ,
and these metabolites were identified by precursor and product ion
scanning using liquid chromatography coupled online with electrospray
ionization tandem mass spectrometry ... |
concentrated drinking water extracts prepared by adsorption onto xad-2 resin have been tested for their ability to induce chromosome damage in mammalian cells .
extracts prepared from drinking waters derived from upland and lowland sources have been found to induce chromosome aberrations in chinese hamster ovary ( ch... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.