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acute lung injury ( ali)/acute respiratory distress syndrome ( ards ) is a frequent complication of sepsis affecting approximately from 25 to 40% of septic patients and carries a mortality of 40% . pathogenesis of sepsis - induced ali proceeds through an early phase characterized by granulocyte migration inside capil...
gadolinium chloride ( gdcl3 ) , a kupffer cells inhibitor , attenuates acute lung injury ; however , the mechanisms behind this effect are not completely elucidated . we tested the hypothesis that gdcl3 acts through the inhibition of lung parenchymal cellular apoptosis . two groups of rats were injected intraperito...
tyrosine phosphorylation of proteins , controlled by tyrosine kinases and protein tyrosine phosphatases , plays a key role in cellular growth and differentiating . a wide variety of hormones , growth factors , and cytokines modulate cellular tyrosine phosphorylation to transmit signals across the plasma membrane to t...
the translabyrinthine ( tl ) approach for resection of a vestibular schwannoma ( vs ) is considered the most reliable method for complete tumor removal . in addition , it is generally associated with better facial nerve function.1 2 however , it is thought to lead to complete hearing loss . the other two common app...
objectives to describe a unique case report of a patient who had partial hearing preservation after translabyrinthine ( tl ) removal of a vestibular schwannoma ( vs ) . study design case report . methods the patient 's chart was reviewed for hearing levels before and after surgery . preoperative magnetic reson...
the attractive and safe ( at safe ) hospital project was initiated in 2006 with the aim of bringing a finnish university hospital into compliance with the magnet standards . the project received national funding during the period between 2009 and 2011 , which significantly increased its scope and made it possible t...
this paper describes the changes in transformational leadership and quality outcomes that occurred between 2008 and 2011 in a finnish university hospital that is aiming to meet the magnet standards . measurements were conducted in 2008 - 2009 and subsequently in 2010 - 2011 by surveying nursing staff and patients . ...
acromegaly is characterized by excessive growth hormone ( gh ) secretion and is primarily caused by a gh - secreting pituitary adenoma , which stimulates the growth of various tissues and impairs the structures and functioning of the heart and great vessels [ 13 ] . cardiovascular disease is known to be the most impo...
background . cardiovascular complications are known to be the main determinants of reduced life expectancy and decreased quality of life in acromegaly patients . our study aimed to provide insight into the cardiovascular changes that occur in acromegaly patients and to investigate the correlative risk factors . metho...
the proportion of cases of the kidney cancer in poland in 2010 was about 3.3% of all new cases , while the upper urinary tract tumors are relatively rare and the rate of new cases is about 0.22% . among kidney cancers , three histological types are the most common : clear cell , papillary and chromophobe . histopatho...
urothelial carcinoma of the upper urinary tract is relatively rare . the standard treatment is invariably radical nephroureterectomy . in selected cases organ sparing surgery is justified . we present the case of the tumor of the kidney pelvis in a solitary organ where laparoscopic approach was successfully appli...
multi - drug resistant bacteria are associated with persistent disease and are continuously expanding around the world , warranting increased attention.1 extended - spectrum -lactamases ( esbls ) are enzymes produced by enterobacteriaceae , including escherichia coli and klebsiella pneumoniae , which invalidate -lactam...
recent studies have reported a widespread distribution of extended - spectrum -lactamase ( esbl)-producing bacteria , not only in the nosocomial setting , but also in the community ; some local communities in southeast asia have been reported to show a high prevalence of esbl - producing bacteria . however , the detail...
the study series included children who took part in the finnish type 1 diabetes prediction and prevention ( dipp ) study ( 12 ) . in dipp , the families of all newborn infants at the university hospitals of oulu , tampere , and turku are offered a possibility for screening of newborn infants for hla risk genes for ty...
objectiveto assess whether the detection of enterovirus rna in blood predicts the development of clinical type 1 diabetes in a prospective birth cohort study . further , to study the role of enteroviruses in both the initiation of the process and the progression to type 1 diabetes.research design and methodsthis was ...
the world in which we live has been under the influence of an extensive territory of goal - oriented human efforts . we are moving from destiny - based societies toward the societies where evolution is made by human factors . dealing with this ever - changing world requires a kind of trust in the people who make mo...
background : in all areas of life including health , choices have widely increased and concerns over getting hold of further choices have made trust a necessary element . this study , taking into consideration the interconnection of three concepts of trust , risk , and body , aims at describing and interpreting diffe...
the aim of this article is to attempt a concise review of the state of the art of the nondestructive biomarkers approach in vertebrates , establishing a consensus on the most useful and sensitive nondestructive biomarker techniques , and proposing research priorities for the development and validation of this promising...
cancer is a leading health problem in india with approximately 1 million new cases occurring every year . out of this , 2 lacks occur in head and neck compared to 30,000 new cases in the united states . carcinoma of the buccal mucosa is the most common oral cavity cancer in india . as per the data available from th...
introduction : head and neck cancer is a leading health problem in india due to the habit of chewing tobacco and bad oral and dental hygiene . carcinoma buccal mucosa is more common and is 2.5% of all malignancies at our center . most of the patients present in stage iii and iv and the survival in these cases is not ...
the adherence rate for chronic medications may be as low as 50%.1 this is of concern as low adherence may negatively affect morbidity and mortality.2 to increase adherence , patient information leaflets have been included in the medication box . however , a study showed that after reading information leaflets on thei...
objectiveto investigate the beliefs of norwegian outpatients about medicines , and to explore if some patient - specific factors and drug use are associated with the beliefs.methodspatients from an outpatient clinic for chronic cardiovascular diseases were referred by physicians to a pharmacist - led medication outpati...
myelodysplastic syndromes ( mds ) are a diverse group of clonal hematopoietic malignancies characterized by ineffective hematopoiesis , progressive bone marrow failure , cytogenetic and molecular abnormalities , and unpredictable risk of further deteriorating into acute myeloid leukemia ( aml ) . pathogenesis of mds ...
th17 cells are a newly found subset of distinct cd4 + th effector cells ' family and are found to play an important role in cancers . myelodysplastic syndromes ( mds ) are a common malignant hematological disease . here , we showed that both the percentage and the function of th17 cells were elevated in low - risk ...
the role of endodontic sealers is to establish a perfect and hermetic periapical environment seal . ideally , these materials should be biocompatible with periradicular tissues , non - absorbable , adaptable to dentin walls and should present good handling characteristics and no cytotoxicity . mineral triox...
objectivethe aim of the present study was to evaluate the radiopacity of portland and mta - based cements using the digora tm digital radiographic system.material and methodsthe performed tests followed specification number 57 from the american national standard institute / american dental association ( 2000 ) for ...
influenza remains thus far a serious problem for many countries in connection with the worldwide spread of this disease . influenza virus infection is an important cause of respiratory infection in the population over the winter season , with peaks in italy , from the end of december to the middle of march . influe...
clinical and epidemiological surveillance of influenza and other acute respiratory infections ( ari ) are currently a major objective of public health . the aim was to describe the epidemiology of influenza using the italian surveillance system . vaccination coverage ( vc ) rates were calculated during 1999 - 2009 ...
quantitative transmission ultrasound ( qtus ) is an imaging modality based on tomographic techniques extended to ultrasound . while transmission ultrasound has been investigated as an adjunct to mammography for quite some time [ 1 , 2 ] , recent developments in hardware and imaging algorithms have enabled marked impr...
quantitative transmission ultrasound ( qtus ) is a tomographic transmission ultrasound modality that is capable of generating 3d speed - of - sound maps of objects in the field of view . it performs this measurement by propagating a plane wave through the medium from a transmitter on one side of a water tank to a hig...
metal - ceramic restorations combine the esthetic advantages of ceramics with the durability and marginal fit of cast substrates . in recent years , titanium has become a material of great attention in dentistry , because of its good biocompatibility and mechanical properties . the high melting temperature and viol...
purpose of the study : it is difficult to achieve a reliable bond between the titanium and veneering porcelain . the aim of this study was to evaluate the bond strength between titanium ceramic crowns.materials and methods : the surfaces of titanium copings were divided in two groups . group a sandblasted with 250 um...
recent advances in nano / microparticle technology have accelerated the application of these particles in biomedicine . various promising and potential applications of these particles have been reported , including tissue engineering,1 diagnostics,2 cancer therapy,3 and drug delivery.4,5 however , many papers on the ...
pulsed laser interaction with small metallic and dielectric particles has been receiving attention as a method of drug delivery to many cells . however , most of the particles are attended by many risks , which are mainly dependent upon particle size . unlike other widely used particles , biodegradable particles ha...
since the deinstitutionalization in the 1960s and 1970s , several community - based care services have been developed for persons with severe mental health problems , such as assertive community treatment ( act ) , brokerage and clinical and strengths case management ( bedell , cohen , & sullivan , 2000 ; burns , 2001 ...
background and aims : interferential care differs from the current community - based care programs in that it targets a larger , heterogeneous group and combines brokerage and full service elements in a multi - organizational care team . the team provides all the services itself , but with the aim to prepare clients ...
the prevalence of childhood obesity in the usa has tripled since 1980 and now affects 12.5 million school - age children and adolescents [ 1 , 2 ] . associated with this epidemic is the rising prevalence of metabolic syndrome among adolescents , particularly in obese teens ( 12.4 to 44.2% ) . the components of metabo...
adolescents committed to improvement of nutrition and physical activity ( action ) was undertaken to determine feasibility of a school - based health center ( sbhc ) weight management program . two urban new mexico sbhcs were randomized to deliver action or standard care . action consisted of eight visits using mot...
war wounds caused by firearms , represent damage to the body , whose features are extensive destruction of the tissue , primary contamination with polymorphic bacterial flora and altered reactivity of the organism ( 1 ) . war trauma injuries are usually injuries to the extremities ( about 70% ) , out of which about 4...
introduction : results of the treatment of open fractures primarily depend on the treatment of connected soft tissue injuries.objective:the aim was to present the experience and methods gained during the treatment of diaphyseal bone defects as a consequence of gunshot fracture soft war trauma.patients and methods : the...
the prognosis in patients with refractory / relapsed adult acute lymphoblastic leukemia ( all ) is dismal . currently , there is no standard salvage therapy for such patients and the only realistic strategy resides in getting another complete remission ( cr ) followed by a successful allogeneic hematopoietic stem cel...
nine pretreated patients aged > 19 years with relapsed / refractory acute lymphoblastic leukemia ( all ) were treated with a combination of bortezomib plus chemotherapy before allogeneic hematopoietic stem cell transplantation ( allo - hsct ) . eight ( 88.9% ) patients , including two philadelphia chromosome - positi...
alzheimer disease ( ad ) is one of the most prevalent health problems among seniors . it is a chronic neurodegenerative disease characterized by progressive cognition impairment and short - term memory loss , which usually deteriorates with aging . it suggests that the initial pathological event in ad is triggered ...
backgroundalzheimer disease ( ad ) is a chronic neurodegenerative disease that is one of the most prevalent health problems among seniors . the cause of ad has not yet been elucidated , but many risk factors have been identified that might contribute to the pathogenesis and prognosis of ad . we conducted a meta - a...
chronic obstructive pulmonary disease ( copd ) is primarily a smoking - related lung disease and afflicts more than 200 million people worldwide . , airway inflammation leads to increased mucus production and reduced mucociliary clearance , causing bronchoconstriction and airflow limitation . patients with copd fre...
background . chronic obstructive pulmonary disease ( copd ) is a common , smoking - related lung disease . patients with copd frequently suffer disease exacerbations induced by bacterial respiratory infections , suggestive of impaired innate immunity . low - dose oxygen is a mainstay of therapy during copd exacerba...
under general anesthetics , decreased hearing sensitivity is common in both animal research and clinical settings . several studies have demonstrated that different anesthetics increase auditory brainstem response thresholds [ 13 ] and depress neural excitability in the auditory midbrain [ 4 , 5 ] and cortex [ 68 ] ....
the cochlea converts sound vibration into electrical impulses and amplifies the low - level sound signal . urethane , a widely used anesthetic in animal research , has been shown to reduce the neural responses to auditory stimuli . however , the effects of urethane on cochlea , especially on the function of outer h...
the lazio region is known for certain products of animal origin , some of which are protected by trademarks of origin with a large - scale marketing and others characterised by handicraft production , limited , entering in a commercial circuit most private and exclusive . consumer safety must be guaranteed for these ...
gentile di maiale is a typical meat product prepared in some traditional plants of latina province ( central italy ) . it is obtained from dehydration , salting , smoking and ripening of swine rectum . aim of this study was to evaluate the influence of the traditional smoking process on polycyclic aromatic hydrocar...
diabetes mellitus ( dm ) is a major global health problem affecting , according to the world health organization , more than 346 million people worldwide . it is one of the most severe metabolic disorders in humans characterized by hyperglycemia due to a relative or an absolute deficiency of insulin or the resistance...
diabetes mellitus ( dm ) induces a large number of diseases of the nervous , cardiovascular , and some other systems of the organism . one of the main causes of the diseases is the changes in the functional activity of hormonal signaling systems which lead to the alterations and abnormalities of the cellular processe...
within the oral cavity exists a biofilm colonized by more than 500 different microbial species , very few of which are actually associated with periodontal disease [ 13 ] . these periopathogenic gram - negative bacteria contain multiple virulence factors , including lipopolysaccharide ( lps ) , which can induce the h...
in periodontal disease , host recognition of bacterial constituents , including lipopolysaccharide ( lps ) , induces p38 mapk activation and subsequent inflammatory cytokine expression , favoring osteoclastogenesis and increased net bone resorption in the local periodontal environment . in this paper , we discuss evi...
haitian immigrant women residing in little haiti , a large ethnic enclave in miami - dade county , experience the highest cervical cancer incidence rates in south florida . between 20072009 , disease incidence in little haiti ( 34 per 100,000 women ) was nearly four times higher than that reported for the miami metro...
background . haitian immigrant women residing in little haiti , a large ethnic enclave in miami - dade county , experience the highest cervical cancer incidence rates in south florida . while this disparity primarily reflects lack of access to screening with cervical cytology , the burden of human papillomavirus ( ...
many liposome studies have been undertaken to develop a wide variety of amphiphilic - associated conjugates containing a polyethylene glycol ( peg ) segment as a modifier , such as peg bonded to dimyristoyl phosphatidylethanolamine ( dmpe - peg)1 or to distearoyl phosphatidylethanolamine / methoxypolyethylene glycol ( ...
backgroundthe abc phenomenon is described as a syndrome of accelerated clearance of polyethylene glycol ( peg)-modified liposomes from the bloodstream when repeatedly injected , with their increased accumulation in the liver and spleen.methodsto clarify this immune response phenomenon , we evaluated a novel modified ph...
to improve patient safety , knowledge of the scale of patient safety incidents and the prevention thereof is important , but the response to patient safety incidents that have already occurred is also valuable . the response to patient safety incidents encompasses how they are dealt with and how their damage can be m...
objectiveswe performed a systematic review to assess and aggregate the available evidence on the frequency , expected effects , obstacles , and facilitators of disclosure of patient safety incidents ( dpsi).methodswe used the preferred reporting items for systematic reviews and meta - analyses ( prisma ) guidelines for...
dental treatment in young children between 15 months and 6 years of age may be a challenge for both the child and the dentist . some current behavior management techniques may help to reduce resistant negative behaviors and facilitate the acceptance of the treatment by the child . although such techniques are effecti...
abstractobjectiveproviding a safe and efficient dental treatment for a young patient is a challenge for the dentist and the child . the purpose of this study was to investigate the effectiveness , safety and acceptability of buccal midazolam in dental pediatric patients and to compare it with oral midazolam.methodsei...
to describe how case management can improve the transition between services for returning servicemen injured in war zones who often have very complex and multiple injuries . studies ; literature relating to care of casualties from war zones ; statistical evidence on casualty numbers and type of injuries . this p...
purposeto describe how case management can improve the transition between services for returning servicemen injured in war zones who often have very complex and multiple injuries.contextreviews a project undertaken for the ministry of defence in the uk.data sourcescase management across secondary and primary care stu...
gastric volvulus is a rare condition that comes in two subsets : organoaxial and the less frequent mesenteroaxial volvulus ( 29% ) . an organoaxial volvulus rotates around the long axis of the stomach that bisects from the gastroesophageal junction and the pylorus of the stomach . on the other hand , a mesenteroaxial...
mesenteroaxial volvulus is a form of gastric volvulus that rotates around the short axis of the stomach . mesenteroaxial volvulus typically presents secondary to an anatomical defect with symptoms that include epigastric pain , retching , dysphagia and early satiety . our patient presented with episodic abdominal pai...
temporal bone metastasis of hepatocellular carcinoma ( hcc ) has rarely been reported.1 only one case of facial nerve palsy due to temporal bone metastasis of hcc has been reported and it was detected by autopsy.2 we encountered a case of metastatic hcc to the temporal region of the skull that initially presented as fa...
facial nerve palsy due to temporal bone metastasis of hepatocellular carcinoma ( hcc ) has rarely been reported . we experienced a rare case of temporal bone metastasis of hcc that initially presented as facial nerve palsy and was diagnosed by surgical biopsy . this patient also discovered for the first time that h...
during 2012 , we collected fecal specimens from sheltered dogs in northern hungary to detect enteric viruses . of 63 samples obtained from 50 animals , 37 randomly selected samples ( from 33 animals ) were subjected to random primed reverse transcription pcr and semiconductor sequencing by using the ion torrent pgm pla...
we identified unusual rotavirus strains in fecal specimens from sheltered dogs in hungary by viral metagenomics . the novel rotavirus species displayed limited genome sequence homology to representatives of the 8 rotavirus species , a h , and qualifies as a candidate new rotavirus species that we tentatively named ...
crohn 's disease ( cd ) is a chronic relapsing and remitting inflammatory disorder of any part of the gastrointestinal tract . to date , the incidence and prevalence of cd are increasing in china [ 1 , 2 ] . although accumulating evidence indicates that cd is the consequence of a dysregulation of innate and adaptiv...
this study was undertaken to evaluate the efficacy of infliximab ( ifx ) in treatment of crohn 's disease ( cd ) patients . 106 cd patients were undergoing treatment with ifx from five hospitals in shanghai , china . clinical remission to ifx induction therapy was defined as crohn 's disease activity index ( cdai )...
the chinese population in the netherlands , as in many other countries , has increased greatly in the last ten years . this population is currently approaching 100,000 [ 1 , 2 ] , making it the fourth largest ethnic minority in the country as well as one of the longest established . in this paper chinese not only ...
this study examines utilisation of the dutch health care system by chinese people in the netherlands as well as their attitudes to the system , paying special attention to mental health . information was gathered by semistructured interviews ( n = 102 ) . the main issues investigated are access , help - seeking beh...
introduction : symptomatic cervical disc disease ( scdd ) causing radiculopathy is a common diagnosis traditionally treated surgically with anterior cervical discectomy and fusion ( acdf ) . objective : the purpose of this trial is to compare the safety and efficacy of total disc arthroplasty ( tda ) using the prodis...
selected abstracts delivered at the 10th annual aospine north america fellows forumconsistent with ebsj 's commitment to fostering quality research , we are pleased to feature some of the most highly rated abstracts from the 10th annual aospine north america fellows forum in banff , canada . enhancing the quality of ev...
they are involved in almost all cellular processes of living organisms such as communication with the outside world , transport of molecules and ions across membranes and energy generation processes . their vital importance is reflected in their high frequencies ( 2030% of total number of proteins ) in various genome...
the topology data bank of transmembrane proteins ( topdb ) is the most complete and comprehensive collection of transmembrane protein datasets containing experimentally derived topology information currently available . it contains information gathered from the literature and from public databases available on the in...
the azorean archipelago is in the middle of the north atlantic ocean and is sometimes in the route of tropical cyclones and lesser storms . this archipelago is made of nine islands and the fruit production in each island is intimately related to their own geographic location and topographic conditions ( batista...
population dynamics studies are very important for any area - wide control program as they provide detailed knowledge about the relationship of medfly [ ceratitis capitata ( wiedemann ) ] life cycle with host availability and abundance . the main goal of this study is to analyse seasonality of c. capitata in te...
mammals express three aurora kinases , aurora a , aurora b , and aurora c , encoded by the genes aurka , aurkb , and aurkc . aurora c expression is mainly restricted to testis , where it functions during meiosis , whereas aurora a and b play key functions regulating mitosis . aurora a is localized to the ...
we present the structure of the human aurora b kinase domain in complex with the c - terminal aurora - binding region of human incenp and the aurora kinase inhibitor vx-680 . the structure unexpectedly reveals a dimeric arrangement of the aurora b : incenp complex , which was confirmed to exist in solution ...
a 67-year - old man visited severance hospital due to persistent and aggravated lower urinary tract symptoms ( luts ) following a ktp laser pvp 3-month ago in another hospital . the international prostate symptom score ( ipss ) was 21 , the qol score was 5 . a bladder neck contracture was considered , and transuret...
we report on a case of a 67-year - old man who presented with persistent lower urinary tract symptoms following a potassium titanyl phosphate laser photoselective vaporization of prostate . upon further diagnostic examinations were performed , he was noted to have an obliterative bladder neck contracture with an inci...
the clinical outcome of phase i trials is usually descriptive due to small patient numbers . still , there is evidence that a significant number of patients with acrc derive clinical benefit , at least in the form of meaningful prolonged disease stabilisation . moreover , patient selection based on clinical paramet...
introduction . a survey was sent to referring oncologists ( ros ) to explore the reasons behind their referral patterns and perceptions of phase i studies before and after being provided with outcome data from advanced colorectal cancer ( acrc ) patients who participated in phase i trials at the royal marsden hospita...
several parameters of the immune system exhibit circadian rhythms which refer to daily oscillations with a period of approximately 24 hours [ 1 , 2 ] . for instance , the number of specific immune cells ( e.g. , monocytes , neutrophils , and lymphocytes ) in circulation and plasma levels of cytokines ( e.g. , tnf- ...
several parameters of the immune system exhibit oscillations with a period of approximately 24 hours that refers to circadian rhythms . such daily variations in host immune system status might evolve to maximize immune reactions at times when encounters with pathogens are most likely to occur . however , the mecha...
infections by endoscopes have been described as a consequence of insufficient cleaning and disinfection , . reports regard duodenoscopes , coloscopes , and bronchoscopes , and concern exists regarding the possible transmission of infective agents like hepatitis b-/c- virus , hiv , mycobacterium tuberculosis and hel...
insufficient performance of cleaning and disinfection of flexible endoscopes can pose an infection risk to patients . actually quality of reprocessing is checked by performing microbiological cultures . unfortunately , their results are not available on the same day so that more rapid methods are desirable . we c...
arrhythmogenic right ventricular cardiomyopathy / dysplasia ( arvc / d ) is a myocardial disease that predominantly affects the right ventricle ( rv ) , although biventricular involvement may occur in advanced cases . arvc / d is characterized by structural derangements that may cause a broad range of signs and sympt...
purposearrhythmogenic right ventricular cardiomyopathy / dysplasia ( arvc / d ) is a myocardial disease that predominantly affects the right ventricle ( rv ) . its hallmark feature is fibro - fatty replacement of rv myocardium . however , patchy inflammatory infiltrates in the rv are also consistently reported usin...
metal ceramic crowns and fixed dental prosthesis have been widely used in clinical practices because of their good mechanical properties and acceptable aesthetics,12 regardless of the development of all ceramic crowns.34 noble metal ceramic alloys have been frequently used for the fabrications of metal ceramic restorat...
purposethe purpose of this study was to evaluate the efficacy of two different metal conditioners for non - precious metal alloys for the bonding of porcelain to a cobalt - chromium ( co - cr ) alloy.materials and methodsdisk - shaped specimens ( 2.510.0 mm ) were cast with co - cr alloy and used as adherend materials ...
europe , and africa from 2006 to 2008 to define the relationship between hba1c and average glucose levels . because a full description of this observational study has been published ( 14 ) , a total of 268 individuals with type 1 diabetes and 159 individuals with type 2 diabetes ( age 1870 years ) completed the study...
objectivethe a1c - derived average glucose ( adag ) study demonstrated a linear relationship between hba1c and mean plasma glucose ( mpg ) . as glucose variability ( gv ) may contribute to glycation , we examined the association of several glucose variability indices and the mpg - hba1c relationship.research design and...
the innate immune system senses microorganisms through germ - line encoded receptors , the pattern recognition receptors ( prrs ) , which include the membrane associated toll - like receptors ( tlrs ) . based on the knowledge that stimulation of prrs by pathogen - associated molecular patterns ( pamps ) has a determi...
novel and more effective immunization strategies against many animal diseases may profit from the current knowledge on the modulation of specific immunity through stimulation of innate immune receptors . toll - like receptor ( tlr)2-targeting formulations , such as synthetic lipopeptides and antigens expressed in fus...
forty six clinical cryptococcus isolates obtained from asan medical center and seoul national university hospital in seoul , korea , between 2008 and 2012 were used . all the isolates were grown on yeast peptone dextrose medium ( difco , detroit , mi , usa ) prior to subsequent analysis . the species identification...
cryptococcal infection is primarily caused by two species , cryptococcus neoformans and c. gattii . between the two species , c. neoformans var . grubii is the major causative agent of cryptococcosis in asia . we investigated the molecular characteristics of 46 isolates of c. neoformans from patients with cryptococ...
obesity in adults and in adolescents significantly increases the risk for several chronic diseases including cardiovascular diseases ( cvd ) and type 2 diabetes ( t2d ) [ 1 , 2 ] . excess accumulation of fat inside the abdominal cavity ( visceral adipose tissue : vat ) is associated with altered insulin sensitivity ,...
the dusp1 gene encodes a member of the dual - specificity phosphatase family previously identified as being differentially expressed in visceral adipose tissue ( vat ) of severely obese men with versus without the metabolic syndrome . objective . to test the association between dusp1 polymorphisms , obesity - related m...
candida albicans represents the most permeative fungal pathogen colonizing humans . c. albicans is an unicellular yeast of the cryptococcaceae family with a single bud . as a member of the normal microflora , it is present on the skin and the mucous membranes of the upper respiratory tract , gastrointestinal tract and ...
candida albicans represents the most common commensal and opportunistic fungal pathogen colonizing humans . as a member of the normal microflora , it is present on the skin and the mucous membranes of the upper respiratory tract , gastrointestinal tract and female genital tracts . it is therefore not transmitted . ...
obesity has emerged as a public health problem worldwide . indeed , it is now so common that it is replacing the more traditional public health concerns ( i.e. , under nutrition and infectious diseases ) . the prevalence of obesity has increased in the last century and was dramatically accentuated in recent decades ....
background . because the use of bmi ( body mass index ) alone as a measure of adiposity has been criticized , in the present study our aim was to fit a latent variable model to simultaneously examine the factors that affect waist circumference ( continuous outcome ) and obesity ( binary outcome ) among iranian adults...
the sedentary mixed crop livestock smallholding system encompasses > 50 % of poor people resident in east africa . these resource - poor subsistence farmers own only a few animals , yet these animals are one of their principal capital assets . subsistence farmers rely on livestock for food security , financial inco...
this paper is the first attempt to accurately describe the hematological parameters for any african breed of cattle , by capturing the changes in these parameters over the first 12 months of an animal s life using a population - based sample of calves reared under field conditions and natural disease challenge . using...
humans and organisms are exposed to complex mixtures of hazardous chemicals at superfund sites or in waters impacted by oil spills . characterizing exposure and associated risks in these scenarios for example , natural ultraviolet b ( uvb ) radiation and technologies used for in situ contaminant remediation ( chemica...
the authors investigated coupling passive sampling technologies with ultraviolet irradiation experiments to study polycyclic aromatic hydrocarbon ( pah ) and oxygenated pah transformation processes in real - world bioavailable mixtures . passive sampling device ( psd ) extracts were obtained from coastal waters impac...
mta is indicated as the material of choice for root - end - fillings and root perforation treatment . the bioactivity of mta led to the interest at the development of new dental materials based on calcium silicates , including root canal sealers . mta fillapex ( angelus industry dental products s / a , londrina...
mineral trioxide aggregate ( mta ) is a calcium silicate - based material . new sealers have been developed based on calcium silicate as mta fillapex and mta plus . objective the aim of this study was to evaluate biocompatibility and bioactivity of these two calcium silicate - based sealers in culture of human dent...
the occlusal relationship and spacing in deciduous dentition is known to have a vital bearing on the setting up of the normal occlusal relationship in permanent dentition.1 the ideal occlusion and spacing in primary dentition acts as mirror for the prevalence of malocclusion in the permanent dentition . the properly ...
background : the aim of the current study was carried to determine the relation of spacing , closed dentition , and occlusal relation with malocclusion in the primary dentition in children during deciduous dentition period among school children of davangere.materials and methods : a total of 945 school children all hav...
the dcct was a multicenter randomized trial of intensive versus conventional diabetes therapy for type 1 diabetes in the development and progression of microvascular diabetes complications . all participants were between the ages of 13 and 39 years and had baseline a1c levels greater than 3 sds above the mean for ind...
objective progressive nephropathy represents a substantial source of morbidity and mortality in type 1 diabetes . increasing albuminuria is a strong predictor of progressive renal dysfunction and heightened cardiovascular risk . early albuminuria probably reflects vascular endothelial dysfunction , which may be medi...
patients with atypical skull base osteomyelitis ( sbo ) are difficult to diagnose because multiple cranial nerve deficits mimicking symptoms caused by mass located at a posterior fossa often develop , even without definite abnormalities suspicious of ear problems ( 1 ) . mastoiditis can result in intracranial complic...
skull base osteomyelitis ( sbo ) is difficult to diagnose when a patient presents with multiple cranial nerve palsies but no obvious infectious focus . there is no report about sbo with septic pulmonary embolism . a 51-yr - old man presented to our hospital with headache , hoarseness , dysphagia , frequent choking , ...
data from 8,301 patients with type 2 diabetes referred to the royal prince alfred hospital diabetes centre in sydney , australia , from 1989 to 2007 were available for study . these patients had a full complications assessment , and data were collected following a standardized protocol as described previously ( 5 ) ....
objective to test the hypothesis that age of type 2 diabetes onset influences inherent susceptibility to diabetic retinopathy , independent of disease duration and degree of hyperglycemia.research design and methods retinopathy data from 624 patients with a type 2 diabetes duration of 2030 years ( group a ) were anal...
viruses are common habitants of the human population , where they establish different forms of infection , including an acute , a chronic , or a persistent infection with production of low levels of virions . some viruses can exist in a true latent state in which infectious particles are only produced upon reactivati...
viruses are intracellular parasites that ensure their existence by converting host cells into viral particle producing entities or into hiding places rendering the virus invisible to the host immune system . some viruses may also survive by transforming the infected cell into an immortal tumour cell . micrornas are...
congential absence of the posterior atlas arch is rare . cases may appear as partial clefts or even total agenesis of the posterior arch . they are mostly found incidentally in asymptomatic patients , but symptoms vary from mild neck pain to neurologic deficitis after traumatic injury . partial clefts are prevalent...
posterior atlas arch anomalies are relatively common , but have a variety of presentations ranging from partial clefts to complete agenesis of the posterior arch . partial clefts are prevalent in 4% of patients and are generally asymptomatic . however , complete agenesis of the posterior arch is extremely rare . we...
oral candidiasis is an infectious condition caused by the fungus of the genus candida , the most common of which is candida albicans . oral candidiasis significantly occurs to the immunocompromised individuals , namely , patients with aids immunosuppression , cancer chemotherapy / radiation therapy , corticosteroid t...
the mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral candidiasis . the mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol ) by freeze / thaw crosslinking technique . 32 full factorial design was employed to optimiz...
many devastating and currently untreatable human diseases arise from the loss or malfunction of specific cell types in the body . this is particularly true for age - related diseases such as lung diseases , neurologic degenerative diseases , type 2 diabetes , and heart failure,1 as well as for other medical condition...
regenerative or stem cell therapy is an emerging field of treatment based on stimulation of endogenous resident stem cells or administration of exogenous stem cells to treat diseases or injury and to replace malfunctioning or damaged tissues . current evidence suggests that in the lung , these cells may participate i...
the denture cleansing agents , composition , and their manufacturer information are listed in table 1 . chemical composition , product name , manufacturers of chemical disinfectants a total of 100 samples were made using a custom - made metallic mold , which consists of a base , middle plate , and a lid . six recta...
aims : the aim was to evaluate and compare the effects of three chemically different commercially available denture cleansing agents on the surface topography of two different denture base materials.materials and methods : three chemically different denture cleansers ( sodium perborate , 1% sodium hypochlorite , 0.2% c...
its main characteristics are : limited social interests , stereotypic behaviors , limited social communications , and impaired social interactions . in addition , more evidence must be provided for many of the suggested interventional approaches in children with autism . n - acetylcysteine ( nac ) is a precursor to...
there are a limited number of food and drug administration ( fda)-approved medications for the treatment of autism . meanwhile , oxidative stress and neuroinflammation are supposed to play a causative role in autism . n - acetylcysteine may provide cystine , a precursor for glutathione ( gsh ) , which is an importa...
modern clinical psychology tries to reduce suffering from diseases and improve quality of life by reducing depression and anxiety effects . positive psychology is a new field that tries to identify what makes life more worthwhile . among different subjects in positive psychology , hope , happiness , and life satisf...
backgroundin spite of a significant relation between spirituality and hope , happiness and life satisfaction , the effectiveness of spiritual interventions in the mentioned mental strengths has been less dealt with . the present study is conducted in order to determine the effectiveness of spiritual group interventio...
spermatogonial stem cells ( sscs ) provide the foundation for spermatogenesis that begins with self - renewal and differentiation of spermatogonial stem cells ( sscs ) ( 1 ) . sscs reside within a specialized microenvironment called niche that regulates testicular homeostasis by balancing ssc self - renewal and diffe...
backgroundspermatogonial stem cells are subpopulation of spermatogonial cells in testis tissue that support beginning and maintenance of spermatogenesis . ubiquitin carboxy - terminal hydrolase l1 ( uchl1 ) could be a specific marker for identification of spermatogonial stem cells including spermatogonial sperm cells...
both attention and consciousness refer to complex concepts in search of consensus for definition . consciousness can indicate a state of vigilance or wakefulness , which ranges between comatose states to being awake . it can also refer to the conscious processing of a given piece of information , such as being...
the relationships between spatial attention and conscious perception are currently the object of intense debate . recent evidence of double dissociations between attention and consciousness cast doubt on the time - honored concept of attention as a gateway to consciousness . here we review evidence from behavioral ...
a six - month - old cyanotic child diagnosed with double outlet right ventricle ( dorv ) with ventricular septal defect ( vsd ) and pulmonary stenosis ( ps ) was admitted to the emergency room . the patient s birth weight was 3.3 kg and the patient weighed 7.1 kg at arrival . echocardiography revealed dorv , a larg...
double outlet right ventricle ( dorv ) and transposition of the great arteries ( tga ) with ventricular septal defect ( vsd ) and pulmonary stenosis ( ps ) are complex heart diseases , the treatment of which remains a surgical challenge . the rastelli procedure is still the most commonly performed treatment . aorti...
perivascular nerves have been identified in close proximity to smooth muscle layers in the cerebral vessel[13 ] and the density of innervations of cerebral resistance vessels have been reported to be similar to the mesenteric and/or the femoral arterial beds.[45 ] astrocytes and vascular cells in association with the p...
cerebral vasculature is richly innervated by the -1 adrenergic receptors similar to that of the peripheral vasculature . however , the functional role of the -1adrenergic receptors in cerebral blood flow ( cbf ) regulation is yet to be established . the traditional thinking being that during normotension and normoc...
cutaneous polyarteritis nodosa ( cpan ) is an uncommon and rare form of cutaneous vasculitis . it should be differentiated from systemic polyarteritis nodosa ( pan ) due to the different clinical course and management of the two conditions . the diagnosis is based on skin biopsy , as there are no specific serologic...
cutaneous polyarteritis nodosa ( cpan ) is a rare form of cutaneous vasculitis that involves small and medium sized arteries of the dermis and subcutaneous tissue without systemic involvement . it presents with tender subcutaneous nodules , digital gangrene , livedo reticularis and subcutaneous ulcerations . the di...
the channels for the droplet production are 25 m . to make the microfluidic devices , crosslinker and pdms were added together at a ratio of 1:10 crosslinker : pdms and the solution was poured on the wafers ( which were cleaned with isopropanol ) . thereafter , the devices were put in the oven at 65 c for at least tw...
understanding the dynamics of complex enzymatic reactions in highly crowded small volumes is crucial for the development of synthetic minimal cells . compartmentalised biochemical reactions in cell - sized containers exhibit a degree of randomness due to the small number of molecules involved . however , it is unkn...
numerous neck muscles are involved in neck movements , and so isolated neck weakness is extremely uncommon in cerebral infarction . we report herein the case of a 65-year - old woman with hypertension and acute cortical infarction , presenting with ipsilateral head tilt and contralateral sensory changes in the neck a...
backgroundnumerous neck muscles are involved in neck movements , and so isolated neck weakness is extremely uncommon in cerebral infarction.case reportwe report herein the case of a 65-year - old woman with hypertension and acute cortical infarction , presenting with ipsilateral head tilt and contralateral sensory chan...
the lifetime prevalence of urinary stones is around 1% to 15% , and the peak age of incidence is at 30 years . ureteral stones account for 20% of the calculi in urolithiasis and about 70% of ureteral stones are present in the distal third of the ureter at the time of presentation . almost 50% of ureteral stones wil...
purposethis study aimed to compare the safety and efficacy of tamsulosin and tadalafil as medical expulsive therapy for distal ureteral stones.materials and methodsthis prospective randomized study was conducted at the department of urology of bir hospital over a period of 12 months in patients with distal ureteral sto...
depression is becoming a very important issue in modern society . with ensuing social problems to be expected , it may become the disease with the greatest social burden after ischemic heart disease1 , 2 . considering that depression is the most common psychological problem in old age3 , more psychological pr...
[ purpose ] the purpose of this study was to investigate the prevalence of depression among elderly patients and identify the factors influencing depression in a geriatric hospital in korea . [ subjects ] a self - report questionnaire was administered to the patients in community geriatric hospitals . partici...
oral anticoagulants are widely used in the prevention and treatment of venous and arterial thrombotic events . bleeding is the major side effect of warfarin therapy , but other nonhemorrhagic adverse reactions are also considerable . warfarin - induced skin changes are relatively uncommon side effects of warfarin t...
warfarin is typically prescribed for patients with thromboembolic diseases and atrial fibrillation . in addition to the complications of bleeding , allergic skin reaction is one of its rare adverse effects . we herein report a case of a 79 year old male patient with leukocytoclastic vasculitis and proteinuria secon...
hand , foot , and mouth disease ( hfmd ) is a viral infectious disease that commonly occurs in infants and young children ( mostly 5 years of age ) . it is typically characterized by the sudden appearance of erythematous papulovesicular eruptions on the hand , feet , perioral area , knees , and buttocks and inside th...
enterovirus 71 ( ev71 ) is a major pathogen for severe hand , foot , and mouth disease ( hfmd ) , which leads to severe neurological complications and has high morbidity and mortality . reliable biomarker for the prediction of deterioration in ev71-infected children with central nervous system ( cns ) involvement may...
the angiogenic effect of vascular endothelial growth factor [ vegf ] , mediated by two receptors , fms - like tyrosine kinase ( flt ) and kinase insert domain protein receptor ( flk ) receptor that play important role for implantation in decidual angiogenesis and uterine vascular permiability ( 1 ) . hormonally contr...
objective(s):progestrone is a prequisite for pre - implantation angiogenesis and induce decidual angiogenesis . it is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre - implantation time.material and methods : adult female nmri mice were divided in three groups [ cont...
the ultimate goal of root canal treatment is to eliminate bacteria and their by - products . thus , the conjunction of instrumentation along with various irrigation solutions and medicaments has been suggested . as the infections of the root canal system are known to be polymicrobial in nature , antibiotic combinatio...
aim : to evaluate the effects of calcium hydroxide ( ch ) , triple and double antibiotic pastes ( daps ) on the bond strength of smart - seal obturation , c - points with endosequence bio - ceramic ( bc ) sealer to the root canal dentin.materials and methods : sixty - four freshly extracted single - rooted human mandib...
hypertension and its cardiac , cerebrovascular , and renal complications are the most important causes of morbidity and mortality , and poor hypertension control is an important factor in the rising epidemic of cardiovascular disease in the developing countries . as in the rest of the world , however , little was kno...
worldwide , both hypertension and chronic kidney disease are major public health problems , due to their epidemic proportions and their association with high cardiovascular mortality . in 2003 , the first prevalence , awareness , treatment , and control of hypertension in turkey ( the patent ) study was conducted in ...
about 8 - 10% of normal northern europeans are heterozygous carriers of common flg mutations , while only 1 - 4% of southern europeans display these mutations , and only very rarely are mutations detected in african populations . although mutations are found in asians , they are different from those encountered in no...
a living kidney donor can improve the quality of life and offer a survival advantage to the recipient . since 1998 , as per organ procurement and transplantation network data , there have been approximately 309,319 kidney transplantations and of these approximately 108,150 are from living kidney donors . the shorta...
evaluation of the potential kidney donor is a complex activity that differs substantially from other types of preoperative assessments . the well being of the donor , who derives no medical benefit from this surgery , must be assured in both the short term and long term , and the potential adverse consequences to the...
diabetes is a common chronic disease that affects millions of americans . as of 2011 , 11.3% of people 20 years or older had diagnosed and undiagnosed diabetes ( 1 ) . forecasts suggest a continued increase in the population burden of diabetes during the next few decades , with 1 in 3 adults in the u.s . at risk fo...
objectivetype 2 diabetes is increasingly common and associated with substantial morbidity and mortality . this study examines trends in the patterns and costs of drug treatment of type 2 diabetes from 1997 to 2012.research design and methodswe conducted descriptive analyses of cross - sectional data using the ims hea...
studies have shown that gingival tissue can be affected in pregnancy . although pregnancy itself does not result in gingivitis typical feature of pregnancy gingivitis is that the gums appear red , swollen with smooth texture and increased bleeding tendency . the pregnancy - related gingival changes usually resolve ...
aim : to compare pregnant and non - pregnant females for vitamin d level and periodontal status and to determine if there is any association between the periodontal health and hypovitaminosis d in pregnant women.materials and methods : a cross - sectional study was conducted in jhelum , pakistan . participants were p...
when considering exercise in cancer , several factors have to be taken into consideration , in particular those alterations that could limit the capacity to perform exercise and consequently the resulting beneficial or detrimental effects . actually , many cancer patients suffer from chronic fatigue , either from the d...
cancer cachexia is a complex syndrome characterized by inflammation , body weight loss , muscle , and adipose tissue wasting that is responsible for the death of a considerable percentage of cancer patients . in addition , during cachexia muscle strength and endurance are dramatically reduced , limiting the ability t...
a 41-year - old female patient presented to the emergency room with sudden weakness of the legs that began one hour previously . the initial heart rate was at 75 beats / min and blood pressure was at 101/63 mmhg . in addition , the femoral , popliteal , and dorsalis pedis arterial pulses were markedly diminished bi...
abdominal aortic occlusion ( aao ) caused by detachment of cardiac myxoma ( cm ) is a very rare complication in patients with cm . although the nature of cms has been well established , detachment of cm may cause unexpected serious complications such as vicious embolic events . actually , in several cases of aao ca...
on september 16 , 2008 , a 16-year - old boy came to the clnica de olhos do par in par , brazil , with low visual acuity ( 0.54 m ) , an intraocular pressure of 44 mm hg , and pain in the left eye . ophthalmologic examination showed a nematode ( video ) in the anterior chamber of the left eye . the patient ...
a case of human intraocular dirofilariasis is reported from northern brazil . the nematode was morphologically and phylogenetically related to dirofilaria immitis but distinct from reference sequences , including those of d. immitis infesting dogs in the same area . a zoonotic dirofilaria species infesting ...
type 2 diabetes is a metabolic disease categorized , primarily , by reduced insulin sensitivity , -cell dysfunction , and elevated hepatic glucose production . insulin resistance is widely accepted as the starting point for the progression from glucose intolerance to overt type 2 diabetes . therefore understanding th...
although the mechanisms are largely unidentified , the chronic or intermittent hypoxic patterns occurring with respiratory diseases , such as chronic pulmonary disease or obstructive sleep apnea ( osa ) and obesity , are commonly associated with glucose intolerance . indeed , hypoxia has been widely implicated in the d...
the microcrystalline rare - earth - doped ceria - based materials are very good oxide ionic conductors at intermediate temperatures , and these materials have been considered as alternative of the yttria - stabilized zirconia as the electrolyte of the solid oxide fuel cell ( sofc ) . major problem associated with the...
the ionic transport properties of nanocrystalline 20 mol% eu , gd , dy , and ho doped cerias , with average grain size of around 14 nm were studied by correlating electrical , dielectric properties , and various dynamic parameters . gd - doped nanocrystalline ceria shows higher value of conductivity ( i.e. , 1.8 104...
myopathy has frequently been associated with repeated intramuscular injections of narcotic analgesics such as pentazocine , butarphanol , propoxyphene , heroin , piritramide , methadone , and meperidine . pentazocine is a commonly used synthetic narcotic analgesic for moderate to severe pain secondary to various cond...
pentazocine is a commonly used synthetic opioid analgesic for moderate to severe pain secondary to various conditions . complications of parenteral opioid abuse including localized ulcerations , abscess , indurations , and sclerosis are well - documented . we present a rare case of drug abuse due to pentazocine ( f...
the bidirectional signaling pathway between the brain and the gastrointestinal system has been recognized and it has been underlined that emotional feeling can influence the function of the gut and vice versa , the condition of gastrointestinal ( gi ) tract can alter brain functions . one of the first notions in this...
backgroundmajor depressive disorder is a common , debilitating psychiatric disorder , which originates from the interaction of susceptibility genes and noxious environmental events , in particular stressful events . it has been shown that dysregulation of hypothalamus - pituitary - adrenal ( hpa ) axis , imbalance be...
the importance of bacteria in the etiology of periodontal disease and also the association of specific groups of gram ve organisms ( 75% ) is well established . this increasing knowledge of specific bacteria as predominant agents in the development of periodontal diseases led to the use of systemic antimicrobials in ...
background : conventional anti - microbial therapy largely consisted of systemic administration of various drugs effective against periodontal pathogens , but fraught with several problems . based on the concept of local drug delivery a bioresorbable device made of pure fibrillar collagen has been developed . the a...
current information on ebola aimed at the public was downloaded from various websites ; a list is provided in technical appendix . information was retrieved from the european centre for disease control ( ebola factsheet for the general public ) ; the us centers for disease prevention and control ( cdc ; questions and...
public involvement in efforts to control the current ebola virus disease epidemic requires understandable information . we reviewed the readability of ebola information from public health agencies in non ebola - affected areas . a substantial proportion of citizens would have difficulty understanding existing info...
irritable bowel syndrome ( ibs ) is a syndrome that is characterised by spells of abdominal discomfort and pain . according to the rome iii criteria , the diagnosis is based on clinical symptoms in the absence of structural or tissue abnormalities . ibs patients are defined by reporting abdominal complaints at leas...
objectivethe irritable bowel syndrome ( ibs ) population is heterogeneous , harbouring a variety of abdominal symptoms . therefore , ibs is often termed a diagnosis of exclusion. chronic abdominal wall pain ( cawp ) is a poorly recognized entity , frequently caused by the anterior cutaneous nerve entrapment syndrome...
it constitutes about 3 and 0.5% of all intracranial tumors in children and adults respectively . the common sites of these tumors are the lateral ventricles in children and the fourth ventricle in adults . , we describe a series of seven cases of pediatric cpp and also discuss the clinical features , radiological c...
background : choroid plexus papilloma ( cpp ) is a benign neoplasm that arises from the ventricular choroid plexus . the clinical features , radiological characteristics , and treatment have been discussed in this study for a pediatric population.methods:over an eight - year period , seven pediatric ( 12 years ) cpp ...
it requires aggressive treatment and close monitoring in the intensive care unit ( icu ) . intravenous fluids , vasopressor administration , early and appropriate antibiotic therapy , source of infection control as well as ventilator support are essential for the treatment of these patients . however , once there h...
background : fluid management is important in critically patients . the aim of this study was to determine the relationship between fluid balance and adverse outcomes of septic shock.methods:a retrospective study was conducted in the medical intensive care unit ( icu ) of a tertiary university hospital in thailand , ov...
severe left main coronary artery ( lmca ) disease is a critical condition and it requires prompt management when it manifests in the setting of acute coronary syndrome ( acs ) . interventional management with percutaneous coronary intervention ( pci ) or coronary artery bypass graft ( cabg ) is mandatory in this sett...
we report on an octogenarian patient presenting with an acute coronary syndrome due to significant left main coronary artery disease and severe ostial stenosis of the left anterior descending artery disease . emergent bypass graft performed with beating heart consisted of left internal mammary graft to the mid left...
dynamic susceptibility - contrast perfusion magnetic resonance ( mr ) imaging is a commonly used method for the noninvasive assessment of cerebral blood perfusion because of the availability of mr imaging units and lack of exposure to ionizing radiation [ 110 ] . after a bolus injection of intravascular contrast agent ...
perfusion magnetic resonance brain imaging induces temporal signal changes on brain tissues , manifesting distinct blood - supply patterns for the profound analysis of cerebral hemodynamics . we employed independent factor analysis to blindly separate such dynamic images into different maps , that is , artery , gray ...