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the use of metals in orthopedics is widespread , and there has been increasing concern with regards to the possibility of developing cutaneous and systemic hypersensitivity reactions to constituent metals in implant devices .
although hypersensitivity reactions to metals are not common , they require evaluation and m... | total hip and knee replacement surgery using metal alloy devices is common .
type iv allergic reactions to these implants occur , though infrequently .
while uncommon , peri - implant metal allergic reactions may cause significant morbidity for the affected individual including aseptic loosening , pseudotumor form... |
the ichd - ii divides headache attributed to infection into four categories : ( 1 ) headache attributed to intracranial infection , ( 2 ) headache attributed to systemic infection , ( 3 ) headache attributed to hiv / aids , and ( 4 ) chronic post - infection headache .
a diagnosis of headache attributed to an infec... | post - infectious disease syndrome includes both neurological and non - neurological disorders .
however , headache as an isolated or a presenting complaint of post - infectious illness has not been well acknowledged in the literature . in this retrospective observation , patients having daily headache of more than 1... |
there is a scanty literature support describing the incidence , mechanism of lateral dislocations of thoracolumbar spine and its management describing the reduction techniques .
hereby we present an interesting case of extruded disc acting as buttonhole preventing the reduction of lateral dislocation of l1-l2 vertebr... | introduction : there is a scanty literature support describing the incidence , mechanism of lateral dislocations of thoracolumbar spine and its management describing the reduction techniques .
hereby we present an interesting case of extruded disc acting as buttonhole preventing the reduction of lateral dislocation o... |
am fungi and their cmns play a significant role in plant ecosystems and control the fitness and competitiveness of the plant individuals within their cmns .
our current understanding about resource exchange in the am symbiosis is primarily based on experiments with root organ cultures or with single plants that are c... | abstractarbuscular mycorrhizal ( am ) fungi form mutualistic interactions with the majority of land plants , including some of the most important crop species .
the fungus takes up nutrients from the soil , and transfers these nutrients to the mycorrhizal interface in the root , where these nutrients are exchanged ag... |
all of the archival hematoxylin and eosin ( h&e ) stained slides for each patient were reviewed .
the nuclear grades and histologic grades were evaluated according to the nottingham grading system.9 the tumor stages were evaluated according to the 7th edition of the american joint committee on cancer ( ajcc ) criteri... | backgroundthe hedgehog ( hh ) signaling pathway is known to play a critical role in various malignancies , but its clinicopathologic role in breast cancer is yet to be established.methodstissue microarray blocks from 334 cases of breast cancer were prepared .
the expression of six hh signaling proteins including soni... |
the vascular endothelium provides a cellular interface between the circulating blood and the vascular smooth muscle of the blood vessel walls
. it also has an important role in maintaining the balance of the endovascular environment .
many factors , such as peroxide , ox - low density lipoprotein ( ldl ) , angioten... | storage protein 2 ( sp2 ) not only is an important source of energy for the growth and development of silkworm but also has inhibitory effects on cell apoptosis .
endothelial cell ( ec ) apoptosis is an important contributing factor in the development of atherosclerosis ; therefore , study of the antiapoptotic activi... |
it mostly develops in early childhood and is characterized by recurrent episodes of wheezing , breathlessness , and coughing due to airway inflammation and airway hyperresponsiveness .
however , in the majority of children symptoms are virally induced and transient ( so - called transient wheezers ) .
so , the asso... | background .
a reliable asthma diagnosis is challenging in preschool wheezing children .
as inhaled corticosteroids ( ics ) are more effective in asthmatics than in children with transient wheeze , an ics response might be helpful in early asthma diagnosis .
methods .
175 children ( aged two four years ) with ... |
in contrast to genome sequences , which are quickly becoming a commodity , the functional connectivity within a proteome is a much more challenging problem .
the various protein complexes , transient interactions and functional pathways are all context - dependent , and the experimental techniques for their elucidati... | functional partnerships between proteins are at the core of complex cellular phenotypes , and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling , data reduction and annotation .
string is a database and web resource dedicated to protein
protein interactions , includ... |
the study was approved by the local ethics committee and written informed consent was obtained from all study participants . all procedures involving animals were authorized by the local institutional ethical animal committee and by the italian general direction for animal health at the ministry for health .
blood wa... | objective : to track the effects of fingolimod , an approved drug for multiple sclerosis ( ms ) , on the activation of myeloid cells from the periphery to the cns.methods:in vitro and ex vivo immunologic studies coupled with flow cytometry were performed to evaluate the action of fingolimod on lipopolysaccharide ( lps)... |
the treatment of primary and metastatic human brain tumors ( hbts ) faces important challenges due to the presence of the blood brain barrier that limits the diffusion of anticancer drugs .
for instance , while the serum concentrations of etoposide after a dose of 50 mg / m can reach values > 1 mg / l ( ~1.7 m ) ,... | the anticancer drugs screening program is a long and expensive process .
it is estimated that only 5% of drugs entering clinical trials are approved by the fda . moreover , many of the drugs that enter clinical trials are often of limited use in clinical practice , and most cancers remain untreatable .
brain tumors... |
the aim of this report is to present a previously unreported causative organism associated with brown - pigmented hypopyon in a patient with endophthalmitis .
vitreous cultures demonstrated streptococcus bovis infection resulting in a brown - pigmented hypopyon , with uveal pigment found intra- and extracellularly... | purposethe aim of this report is to present a previously unreported causative organism associated with brown - pigmented hypopyon in a patient with endophthalmitis.methodsthis is a retrospective case report which includes clinicopathologic correlations.resultsvitreous cultures demonstrated streptococcus bovis infection... |
oocyte growth is accompanied by follicular growth . once the primordial follicle is activated , a few flattened
granulosa cells become cuboidal and increase in number , while the oocytes increase in size .
follicles are
classified based on morphology and size : primary follicles are surrounded by a single layer o... | in vitro growth of immature oocytes provides opportunities to increase gametic resources and
to understand the mechanisms underlying oocyte development .
many studies on the in vitro
growth of oocytes have been reported thus far ; however , only a few cases have been reported , which
demonstrated that oocytes c... |
hepatitis c virus ( hcv ) is the most common blood - borne infection and a major cause of chronic liver disease , cirrhosis , and primary hepatocellular carcinoma and one of the leading indications for liver transplant . the current standard therapy for chronic hcv ( pegylated - interferon- ( pegifn- ) combined with... | predicting the efficacy of antiviral treatment of hepatitis c virus ( hcv ) is of importance for both patient well - being and health care expense .
the expression of interferon - stimulated genes ( ifn - sgs ) in the liver was suggested as a marker of response to anti - viral therapy .
ifn - sgs encode the guanosi... |
multiple chemical sensitivity ( mcs ) , also known as chemical intolerance ( ci ) or chemical hypersensitivity , is an emerging disabling illness characterized by chronic adverse effects from exposure to low levels of chemicals in the modern human environment .
symptoms can range from mild to disabling and commonly i... | in this paper , we summarize the results of an online survey of persons in the united states with chemical intolerance / multiple chemical sensitivity who sought help from mental health providers , including counselors , psychologists , psychiatrists , and others .
respondents reported on their most recent contact wi... |
a brain computer interface ( bci ) provides an alternative communication channel for healthy or disabled users from their brains to external environment .
a bci system can detect changes of the state of mind from the on - going eeg and control an external device ( e.g. , text - entry system , prosthesis , and comput... | to allow a routinely use of brain computer interfaces ( bci ) , there is a need to reduce or completely eliminate the time - consuming part of the individualized training of the user . in this study
, we investigate the possibility of avoiding the individual training phase in the detection of movement intention in a... |
zotepine is being marketed in india since september 2010 for the treatment of schizophrenia . by presenting this report
, our aim is to share our clinical experience regarding the tolerability and the side effects of zotepine treatment in schizophrenia patients . to our knowledge
, there has been no study conducted... | zotepine is an antipsychotic used in japan and europe for years and recently being introduced in indian markets .
it is claimed to be particularly effective for negative symptoms , and somnolence and weight gain are the most common side effects .
our aim is to share our clinical experience of use of zotepine with r... |
all animal care and experiments conformed to the guidelines for animal experiments of ahe university of tokyo
and were approved by the animal research committee of the university of tokyo .
the left and right zfn plasmids were constructed by the overlap extension pcr and ta cloning ( olta ) method
according to a ... | the generation efficiencies of mutation - induced mice when using engineered zinc - finger nucleases ( zfns ) have
been generally 10 to 20% of obtained pups in previous studies .
the discovery of high - affinity dna - binding
modules can contribute to the generation of various kinds of novel artificial chromatin ... |
the keystone to improving disease management and health outcomes remains the early and accurate diagnosis of the predisposition to , or onset of , disease .
early detection of disease risk and onset is the first step in implementing efficacious treatment and improving patient outcomes . in the context of screening fo... | the aim of this paper is to consider the relative benefits of screening for type two diabetes mellitus in women with a previous pregnancy complicated by gestational diabetes mellitus .
recent studies suggest that women who experience gdm are at a greater risk of developing type 2 diabetes within 1020 years of their i... |
the pectoralis major muscle in humans is a large fan shaped muscle situated at the anterior upper part of the chest .
it is complex in that it has two separate muscular bellies and a dual nerve supply .
the clavicular portion of the pectoralis major muscle arises from the medial one half to two thirds of the clavic... | a unilateral four - headed pectoralis major muscle was observed on the left side of an 83 year - old caucasian male cadaver .
the accessory tendon arises from the lateral aspect of the pectoralis major muscle , travels along with the tendon of the long head of the biceps brachii and blends into the capsule of the sho... |
most obstetrical inpatient stays are short often no more than one or two days and the involvement of the inpatient consultation - liaison ( c - l ) psychiatry service , when required , is necessarily brief . regardless of its compendious quality , however , its impact can have significance for the patient .
we have... | purpose .
twenty - eight women , referred to c - l psychiatry during their obstetrical inpatient stay were interviewed six months post - discharge to determine how they experienced the consultation process , whether they recollected and adhered to treatment recommendations , and whether they developed or had a recurr... |
functional gastrointestinal disorders ( fgids ) are chronic conditions that are considered to have no structural or biochemical abnormalities that account for the symptoms.1 fgids are not life threatening conditions , however , they significantly could impair the quality of life ( qol ) .
fgids are important to publi... | the importance of health - related quality of life ( hrqol ) continues to grow , as clinicians and clinical researchers have recognized the impact of the functional gastrointestinal disorders .
limited information is available on the performance of hrqol questionnaires in asia .
furthermore , the effect across diff... |
the pandemic of obesity is one of the greatest public health risks in industrialized countries . in australia , for instance ,
the prevalence of obesity ( body mass index > 30 ) has more than doubled in the past 25 years .
bariatric surgery is now proven to be the most effective means of achieving sustainable weig... | the laparoscopic adjustable gastric band ( lagb ) is a widely performed procedure for the morbid obesity epidemic . despite its low mortality compared with other mainstream bariatric surgeries ,
it is not without its complications .
the authors report a late and rare complication of a small bowel obstruction in a 5... |
cancer is a complicated disease that develops slowly due to gradual accumulation of genetic and epigenetic alterations over time [ 1 , 2 ] .
tumor cells often harbor mutations followed by activated oncogene expression and inactivated tumor - suppressor expression .
these alterations combined with dysregulation of c... | polo - like kinase 1 ( plk1 ) , one of serine / threonine - protein kinase , has been demonstrated to play pivotal roles in malignant transformation .
here we illustrated the clinicopathological significance of plk1 expression in hepatocellular carcinoma ( hcc ) in more detail .
immunohistochemistry was performed t... |
cochlear implantation outcomes are dependent on several factors that lead to a good prognosis , such as early diagnosis and intervention , systematic rehabilitation , family permeability , and type of communication , as well as other factors related to hearing loss including etiology , period of deafness , and the pres... | summary
introduction : the most relevant clinical symptom in waardenburg syndrome is profound bilateral sensorioneural hearing loss .
aim : to characterize and describe hearing outcomes after cochlear implantation in patients with waardenburg syndrome to improve preoperative expectations .
method : this was an... |
in the current guidelines for treatment of pulmonary arterial hypertension ( pah ) , therapeutic options for hiv - related pulmonary hypertension ( hrph ) are less well established as compared to other forms of pah , and there are still controversial data on the role of the antiretroviral therapy ( art ) in the managem... | we present the case of an hiv / hcv - coinfected patient with hiv - related pulmonary hypertension ( hrph ) who experienced a good clinical and functional response to bosentan , with a subsequent switch to oral sildenafil due to increased transaminase levels .
bosentan resulted less handy in this case , probably due ... |
in the previous issue of critical care , osuka and colleagues from the osaka university hospital and school of medicine examine fecal ph as a proxy for composition and functional alterations in the gut flora that predict outcome in critically ill patients .
this work builds on and extends their previous work examinin... | the composition and function of intestinal microflora are emerging as integral to both health and disease . during critical illness
the normal microbiota are rapidly replaced by pathogenic species as a result of both the physiologic stress itself and the use of antibiotics . in this report
, the authors use fecal p... |
myopic eyes are often accompanied by tilted optic discs , which are associated with a series of findings , including a vertically oval optic disc,13 nasally undermined cupping , 1,4 nasally displaced vessels in the cupping,1,3,4 and the presence of a temporal crescent.13,5 in our clinical practice in japan , we observe... | purposeto determine if qualitatively defining the appearance of optic disc change was a valid characteristic of myopia in subjects with graves ophthalmopathy ( go ) or primary open - angle glaucoma ( poag).methodswe defined typical tilt appearance as the simultaneous presence of the following : an elliptical optic disc... |
ceftriaxone is a widely used third - generation semi synthetic cephalosporin commonly administrated for treatment of different bacterial infections in children . due to its broad spectrum against bacteria ,
long half - life and single daily dosing , physicians prefer to use it more frequently .
ceftriaxone is mostl... | objectiveceftriaxone is a third - generation cephalosporin which is widely used for treatment of infection in children accompanied by complications like urinary tract lithiasis and gallbladder psudolithiasis or sludge .
the aim of this study was to investigate the incidence and predisposing factors that contribute to... |
inhalation induction in adult cardiac surgery patients is not an established procedure as there is fear of hypotension .
volatile agents have cardioprotective properties that might result in a reduction of postoperative mortality in cardiac surgery .
successful inhalation induction for adults in non - cardiac sur... | introductionanesthesia induction through volatile agents is a well - established technique in several fields but not in adult patients undergoing cardiac surgery .
successful inhalation induction requires a poorly soluble , reasonably potent and minimally irritant agent , and the benefits associated to this technique... |
restorative procedures such as cavity preparation are used to remove the infected dentin and make space for the restorative materials .
the successes of these procedures depend on the effective removal of infected dentin , prior to the placement of the restorative material .
any leftover bacterial remnants during a... | aim : the aim was to evaluate the effect of different cavity disinfectants on dentin bond strengths of composite resin applied with two different adhesive systems.materials and methods : two - hundred mandibular molars were sectioned parallel to the occlusal surface to expose dentin in the midcoronal one - third .
th... |
rnai - based library screening has become a powerful in vitro tool to identify drug targets that play a role in disease development and progression ( martin and caplen , 2007 ) .
successful screening experiments using sirna require efficient delivery of highly functional and specific sirna molecules into appropriate ... | meaningful rnai - based data for target gene identification are strongly dependent on the use of a biologically relevant cell type and efficient delivery of highly functional sirna reagents into the selected cell type . here
we report the use of the amaxa nucleofector 96-well shuttle system for sirna screening in pri... |
a 54-year - old african - american male with an unremarkable past medical and family history presented with a gradually worsening and painful swelling of his right middle finger , which severely impaired the use of his hand over several months . on physical examination
, a mass was palpated on the proximal phalanx wi... | the propensity of colon cancer to metastasize to bones is very low compared to prostate , breast or lung cancer .
the reason for this is not yet understood , although an explanation for the osteotropism of certain primaries has been offered by the seed and soil concept , suggesting that the bone microenvironment pro... |
most people employed in economic activities complain neck , shoulders , and lower back
disease . in particular , when one uses a computer in an inappropriate posture for a long
time , the centerline of the head moves forward and upward , which causes an increase in the
weight of the head supported by the neck , u... | [ purpose ] this study performed to investigate the effect of elastic band exercise program
on the posture of subjects with rounded shoulder and forward head posture . [ subjects and
methods ] the body length , forward shoulder angle , craniovertebral angle , and cranial
rotation angle of participants ( n=12 ) we... |
head and neck cancer is the sixth most common human cancer , representing 3% of all types of cancer .
they are located in the oral cavity in 48% of cases , and 90% of these are oral squamous cell carcinoma .
more than 300,000 new cases worldwide are being diagnosed with oral squamous cell carcinoma annually .
app... | oral cancer is one of the major global threats to public health .
oral cancer development is a tobacco - related multistep and multifocal process involving field cancerization and carcinogenesis .
the rationale for molecular - targeted prevention of oral cancer is promising .
biomarkers of genomic instability , i... |
a novel class a serine carbapenemase detected in north carolina in 1996 was given the designation kpc-1 because it was first identified in klebsiella pneumoniae .
since then , a number of variants of this enzyme ( currently up to kpc-8 ) have been identified and have spread globally .
the mobile nature of the genet... | the emergence of the klebsiella pneumoniae carbapenemases in k. pneumoniae and other gram - negative bacteria , usually on a background of multidrug resistance , has led to difficult therapeutic choices . among available antibiotics , tigecycline and
the polymyxins are the most frequently active against these organis... |
nowadays , there are many patients who want to restore their teeth more esthetically not only for the origin such as dental caries or tooth fracture but also for diastema .
as the interests of patients in esthetics increased , a number of reports over the porcelain laminate veneer increased.1,2 interdental spacing in... | if orthodontists and restorative dentists establish the interdisciplinary approach to esthetic dentistry , the esthetic and functional outcome of their combined efforts will be greatly enhanced .
this article describes satisfying esthetic results obtained by the distribution of space for restoration by orthodontic tr... |
asterospicularia laurae utinomi is a moderately abundant soft coral species found in well lit areas of the great barrier reef , especially on reef flats .
fabricius and alderslade have remarked upon the similarity between the polyp structure of asterospicularia and those of the genera xenia and sympodium .
the ch... | an investigation of the soft coral asterospicularia laurae collected on the great barrier reef , australia , afforded the cytotoxic diterpene 13-epi-9-deacetoxyxenicin ( 1 ) in addition to the known metabolites 13-epi-9-deacetylxenicin ( 2 ) and gorgosterol .
13-epi-9-deacetoxyxenicin readily underwent an autoxidatio... |
one of the most popular approaches for identifying loci recently impacted by positive selection is known as hitchhiking mapping
this approach involves scanning across a large number of regions in order to determine the average levels of variability that are characteristic of the genomic environment .
regions that ... | a major focus of modern population genetics involves using polymorphism data in order to identify regions impacted by recent positive selection ( so - called genomic scans ) .
recently , methodology has been proposed not to identify individual loci , but rather to quantify genomic recurrent hitchhiking ( rhh ) parame... |
as ppos become the dominant model of managed health care in the private sector , policymakers have increasingly viewed ppos as an attractive option for medicare . as part of a larger effort to modernize medicare by adopting strategies widely used in the private sector ,
the 2003 medicare prescription drug , improveme... | as preferred provider organizations ( ppos ) become the dominant model of managed health care in the private sector , policymakers have increasingly viewed ppos as an attractive option for medicare . in part to understand how ppos might operate under the medicare program , cms launched the medicare ppo demonstration in... |
acquired esophageal stricture following lye ingestion in children is the most common indication for esophagectomy in children .
stricture dilatation is the primary method of management , but patients with strictures not amenable or responsive to dilatation require esophageal replacement .
failure of esophageal dila... | background : acquired esophageal strictures in children are often the result of ingestion of caustic agents .
we describe 2 children with severe esophageal strictures following lye ingestion , who successfully underwent esophagectomy and gastric pull - up utilizing combined thoracoscopic and laparoscopic techniques.m... |
tissue microarrays ( tmas ) are the perfect tools in pathology and beyond to analyze the abundance and spatial distribution of proteins in well - defined tissue sections by immunohistochemical means.14 the tma block can include up to many hundred or even more patient samples originating from a certain physiological sta... | there are no satisfying tools in tissue microarray ( tma ) data analysis up to now to analyze the cooperative behavior of all measured markers in a multifactorial tma approach .
the developed tool tmainspiration is not only offering an analysis option to close this gap but also offering an ecosystem consisting of qua... |
adnexal masses can be benign or malignant and the benign masses greatly outnumber malignant ones.1 ovarian cancer is one of the most common gynecological malignancies and cause of death in the western world and the usa .
it is also one of the most prevalent cancers in pakistan.2,3 precise characterization of an adnex... | objective : to evaluate the diagnostic accuracy of multidetector 64-slice computed tomography ( mdct ) in the diagnosis and differentiation of benign and malignant ovarian masses using histopathology and surgical findings as the gold standard.material and methods : this study was conducted in aga khan university hospit... |
fever is the most frequent presenting symptom in many ambulatory health care settings.1 the evaluation of a child with a fever is one of the primary - care physician 's most perplexing clinical situations .
fever may herald the onset of a serious and life - threatening disease such as meningitis , or it may be the so... | background : fever is the most common sign of childhood illnesses and febrile children constitute a substantial proportion of the practice of pediatrics and family medicine.objectives:to highlight the pattern of febrile illnesses in children attending pediatric ambulatory health - care settings.methods:a one - year pro... |
since the advent of highly active antiretroviral therapy ( now referred to as combination antiretroviral therapy [ cart ] ) , high levels of adherence are requisite to achieve maximal viral control and to improve immunologic status , which results in fewer acquired immunodeficiency syndrome defining events and lower mo... | atripla ( gilead sciences inc , foster city , ca , usa and bristol - myers squibb , new york city , ny , usa ) is a coformulated single pill composed of efavirenz , emtricitabine , and tenofovir disoproxil , intended as a once - daily potent combination antiretroviral therapeutic agent . its efficacy is equivalent to t... |
the tumor suppressor protein p53 is a
transcription factor that ,
among other functions , up - regulates the expression of genes involved
in cell - cycle arrest , senescence , and apoptosis in response to cellular
stress .
its activity is modulated through key interactions
with coactivators that control its... | the tumor suppressor p53 is a hub protein with a multitude
of binding
partners , many of which target its intrinsically disordered n - terminal
domain , p53-tad .
partners , such as the n - terminal domain of mdm2 ,
induce formation of local structure and leave the remainder of
the domain apparently disorde... |
malaria , a vector borne infectious disease caused by the protozoan parasites ( plasmodium ) and transmitted to humans by the female anopheles mosquito , has remained a real and longstanding cause for concern , mainly in the tropical world .
malaria has now extended to areas that cover more than 40% of the world 's p... | the main objective of this investigation was to determine the absorption , distribution , excretion , and pharmacokinetics of the antimalarial drug pyronaridine tetraphosphate ( pndp ) in sprague - dawley rats .
following oral administration of a single dose ( 10 mg / kg ) of
14c - pndp , it was ... |
the study was performed in accordance with a protocol approved by the institutional review board of the noguchi memorial institute for medical research , and the institutional review board and institutional animal care and use committee of the us naval medical research unit no .
3 . seven sites were selected from are... | two arenaviruses were detected in pygmy mice ( mus spp . ) by screening 764 small mammals in ghana . the natal multimammate mouse ( mastomys natalensis ) , the known lassa virus reservoir , was the dominant indoor rodent species in 4 of 10 sites , and accounted for 27% of all captured rodents .
no rodent captured ind... |
the integrity of the genome is crucial for the correct functioning of the individual organism .
any perturbation that results in a loss of genomic integrity is likely to result in disregulation and consequent uncontrolled cellular proliferation .
maintenance of genomic integrity is orchestrated by a number of diffe... | mutations in brca1 account for the majority of familial aggregations of early onset breast and ovarian cancer ( ~70% ) and about 1/5 of all early onset breast cancer families ; in contrast , mutations in brca2 account for a smaller proportion of breast / ovarian cancer families and a similar proportion of early onset b... |
patients undergoing gynaecological surgery utilising transverse lower abdominal incisions experience severe pain during the first 48 h postoperatively , thus requiring a well - planned analgesia regimen in the post - operative period .
total abdominal hysterectomy ( tah ) is a commonly performed major surgical proced... | background and aims : transversus abdominis plane ( tap ) block has proven to be an effective component of multimodal analgesic regimens for a variety of abdominal procedures .
magnesium sulphate ( mgso4 ) n - methyl - d - aspartate receptor antagonist has the potential to be an ideal adjuvant in tap block .
we stu... |
olfactory disturbances significantly impair the patient 's quality of life1
2
3
4 .
the perception of smell occurs when odorant particles are inhaled and bind to olfactory receptors located in the olfactory neuroepithelium ( on)5 .
the nerve endings in this tissue have a unique capacity to regenerate5
6 , w... | summary
introduction : olfactory neuroepithelium ( on ) biopsy has several therapeutic applications for both disorders of olfaction and neurodegenerative diseases
. successful collection of on is still anything but routine due to a dearth of studies on the distribution of on in the superior and middle turbinates .... |
the induction of synthesis of the " female " yolk precursor protein vitellogenin ( vtg ) in male fish by estrogenic chemicals in the environment has been demonstrated in many recent reports .
however , little is known about the organismal and biological significance of this phenomenon . to examine the relationship be... | |
the enlargement usually leads to lower urinary tract symptoms,1 irrespective of whether it is benign or malignant . with wide acceptance of serum prostate - specific antigen ( psa )
estimation,2 the ability to differentiate malignant from benign prostatic enlargement with or without symptoms before instituting defini... | backgroundprostatic enlargement is a common cause of bladder outlet obstruction in men in nigeria .
malignant enlargements must be differentiated from benign enlargements for adequate treatment of each patient .
high serum total prostate - specific antigen ( tpsa ) levels suggest malignancy , but some of the biopsi... |
obesity is a major worldwide problem , over 30% of adults in western populations are obese , and there is growing evidence of the associated health risks associated [ 15 ] .
the link between obesity and cancer risk has been studied extensively , but the results of individual studies do not suggest a consistent associ... | the objective here was to summarize the evidence for , and quantify the link between , serum markers of lipid metabolism and risk of obesity - related cancers .
pubmed and embase were searched using predefined inclusion criteria to conduct meta - analyses on the association between serum levels of tg , tc , hdl , apo... |
ghrelin is a peptide hormone that is secreted from stomach and circulates in the blood to activate the release of growth hormone from pituitary and stimulate appetite by acting on hypothalamic arcuate nucleus [ 1 , 2 ] .
ghrelin is distributed in several tissues , such as gastrointestinal organs , pancreas , and brai... | to examine the gene expression of ghrelin , a growth hormone releasing and appetite stimulating hormone from stomach , we constructed human ghrelin promoter - reporter vectors and analyzed the promoter activity .
the ghrelin promoter activity was high when cultured cells that express ghrelin mrna endogenously like tt... |
in the united states , 26 million people suffer from diabetes with 1.3 million more being diagnosed with the disease each year.1,2 an aging population , rising obesity rates , and an increasingly sedentary lifestyle have been attributed to the increase in the incidence and prevalence rates .
ten percent of adults and... | backgroundthis study investigated the efficacy of diabetinol in people with diabetes on medication but not meeting the american association of clinical endocrinologists and american diabetes association glycemic , blood pressure , and lipid targets.subjects and methodsfifty subjects , aged 1875 years , with fasting blo... |
individuals with diabetes do not realize the consequences of poorly controlled blood sugars until injury occur [ 14 ] .
the diabetes control and complications trial ( dcct ) showed that glycemic control delays the onset of microvascular and macrovascular complications .
glucose monitoring allows individuals with di... | summarybackgroundthe primary objective of our study is to compare hga1c to self monitoring frequency in diabetes subjects .
a secondary objective is to evaluate the influence of family support and gender on glucose monitoring frequency and hga1c.material/methodswe studied the glucose monitoring frequency and hga1c ou... |
the short qt syndrome ( sqts ) is linked to abbreviated qt intervals on the electrocardiogram and to an increased incidence of cardiac arrhythmias and of sudden death .
the sqt3 variant was identified in an asymptomatic child with an abnormal electrocardiogram and in her father who had a history of presyncopal events... | recently identified genetic forms of short qt syndrome ( sqts ) are associated with an increased risk of arrhythmia and sudden death .
the sqt3 variant is associated with an amino - acid substitution ( d172n ) in the kcnj2-encoded kir2.1 k+ channel . in this study ,
whole - cell action potential ( ap ) clamp record... |
acinetobacter baumannii is a non fermentative gram - negative coccobacillus that is emerged as opportunistic nosocomial pathogen .
a variety of human infections caused by acinetobacter species have been reviewed including pneumonia ( most often related to endotracheal tubes or tracheostomies ) , endocarditis , mening... | aim : the aim of this study was to examine the impact of antibiotic consumption on development of antimicrobial resistance in acinetobacter baumannii.material and methods : the study was conducted in university clinical center of sarajevo . in our retrospective study acinetobacter baumannii isolated in period from july... |
thrombotic thrombocytopenic purpura ( ttp ) is associated with a decrease in the activity of the von willebrand factor - cleaving protease adamts13 .
this decrease can be due to a congenital deficiency or the presence of an inhibitor .
the treatment of ttp in the presence of an inhibitor is plasmapheresis to remove... | we here describe a patient with an idiopathic thrombotic thrombocytopenic purpura ( ttp ) secondary to an adamts13 inhibitor that continued to be dependent on plasmapheresis until the patient was treated with rituximab .
ttp manifestations subsided with rituximab treatment in spite of a persistently low adamts13 acti... |
perioperative myocardial ischaemia ( pmi ) is a serious complication of cardiac surgery , which considerably increases the risk of mortality and morbidity .
patients with a history of pmi are at a higher risk of experiencing early complications than others .
the probability of remaining free of newer cardiac events... | background and aims : perioperative myocardial ischaemia ( pmi ) is one of the known complications during off pump coronary artery bypass ( opcab ) surgeries . the length of hospital stay is considerably prolonged in patients with pmi .
myocardial protection is an area which is being widely researched currently to pr... |
sea buckthorn ( hippophae rhamnoides l. , elaeagnaceae ) constitutes a thorny nitrogen fixing deciduous shrub which cultivated various parts of the world for its nutritional and medicinal values . a sea buckthorn fruits ( figure 1 ) , seed ( figure 2 ) and other parts is primarily valued for its very rich vitamins a , ... | sea buckthorn ( hippophae rhamnoides l. ) constitutes thorny nitrogen fixing deciduous shrub . sea buckthorn(sbt ) is primarily valued for its very rich vitamins a , b1 , b12 , c , e , k , and p ; flavonoids , lycopene , carotenoids , and phytosterols . and therapeutically important since it is rich with potent antioxi... |
empowerment appears to mainly affect the use of prenatal care services and with the promotion of empowerment during pregnancy , we can improve mothers reproductive health ( 1 ) .
it is necessary for all women to make proactive decisions about their health and pregnancy in order to demonstrate their many capabilities ... | introductionconsidering that empowering expectant mothers is an important issue to maintain a healthy pregnancy , this study was conducted to evaluate the predictors of empowerment among iranian pregnant women.methodsthis cross sectional study was conducted in golestan , north of iran in 2015 .
a total number of 161 ... |
type 2 diabetes mellitus is one of the most common and disabling metabolic diseases ; its increasing incidence has become a serious threat to human health .
increasing evidence suggests that hyperuricemia is an independent risk factor for impaired fasting glucose ( ifg ) and type 2 diabetes .
patients with hyperuri... | objective .
the aim of our study was to explore the dependent condition of the relationship between uric acid and blood glucose in type 2 diabetes .
research design and methods .
we measured the hba1c , serum uric acid , creatinine , lipids profiles , and so forth of 605 newly diagnosed type 2 diabetes patients ,... |
it helps by killing microorganisms , flushing debris , and removing the smear layer from the root canal system .
smear layer prevents the penetration of intracanal medicaments into dentinal tubules and influences the adaptation of filling materials to canal walls .
it consists of organic and inorganic substances , ... | aim : the aim of this study was to compare smear layer removal after final irrigant activation with sonic irrigation ( si ) , manual dynamic agitation ( mda ) , passive ultrasonic irrigation ( pui ) , and conventional syringe irrigation ( ci).materials and methods : forty mesial canals of mandibular first molars ( mesi... |
selective laser trabeculoplasty ( slt ) was considered as an effective and safe surgery for lowering intraocular pressure ( iop ) [ 13 ] since it has initially been described in 1995 .
slt , a 532 nm frequency - doubled and q - switched neodymium ( nd ) : yttrium - aluminum - garnet ( yag ) laser , is capable of tar... | purpose . to compare the efficacy of subthreshold and conventional selective laser trabeculoplasty ( slt ) in lowering intraocular pressure ( iop ) in the patients with primary open - angle glaucoma ( poag ) .
methods .
fifty - two eyes from fifty - two poag patients were randomized into two groups , one group trea... |
granular cell tumor also known as abrikossoff 's tumor or granular cell myoblastoma was variably considered as being a true neoplasm , degenerative metabolic process or trauma - induced lesion .
a 9-year - old female patient presented to the dental clinic with a chief complaint of a swelling on the left side of her t... | granular cell tumor , an uncommon neoplasm , can occur at any site in the body , but they are more commonly observed in the head and neck region , especially the oral cavity . a lesion of controversial origin , this entity has to be considered in the differential diagnosis of swellings of the tongue .
immunohistochem... |
advances in minimally invasive surgery have led to the development of many novel surgical techniques .
single - incision laparoscopic surgery ( sils ) and natural orifice transluminal endoscopic surgery ( notes ) are among the techniques that are designed to further reduce surgical trauma and enhance postoperative re... | background and objectives : there has been great enthusiasm for the technique of transanal total mesorectal excision . coupled with this procedure , we performed single - incision laparoscopic surgery for left colon mobilization .
this is a description of our initial experience with the combined approach.methods:pati... |
the aim of every dentist is to fabricate restorations in harmony with the patient 's functional movements , to avoid interferences and subsequent disharmony in the stomatognathic system .
dental articulators accurately simulate patient 's mandibular movements and aid in restoring occlusion . programming semi - adjust... | statement of problem : the accuracy and reliability of the methods used for programming the semi - adjustable articulators determine the accuracy in occlusion .
the current recommended average settings using the hanau 's formula commonly used by clinicians is questionable , and thus reassessment is needed .
this st... |
magnesium ( mg ) is the fourth most abundant cation in the human body and is a critical cofactor in many enzymatic reactions [ 1 , 2 ] .
an australian study demonstrated that hypomagnesaemia was 10.51-fold more common between patients with new diabetes and 8.63-fold more common between patients with known diabetes as... | whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria is still unclear .
the objective of the present study was to elucidate the association between serum magnesium and microalbuminuria in diabetic patients .
a cross - sectional study was conducted in 1829 diabetic s... |
the local inflammatory response to pathogenic bacteria or bacterial products is characterized by infiltration of the periodontal tissues of inflammatory cells including polymorphonuclear neutrophils , macrophages , lymphocytes , and plasma cells .
the acute - phase response is a nonspecific process , initiated and co... | background : c - reactive protein ( crp ) , an acute - phase protein monitored as a marker of inflammatory status , has been identified as a major risk factor for various systemic diseases .
it is a reliable marker to infectious burdens and/or inflammation .
the aim of this study was to compare and evaluate the sys... |
the sternocleidomastoid ( scm ) is a long neck muscle with two bellies , a medially located sternomastoid ( sm ) and laterally positioned cleidomastoid ( cm ) .
the sm is involved in the control of head movements and causes cranial displacement of the sternum and ribcage during conscious respiratory efforts [ 26 ] . ... | the goal of this study was to establish force data for the rat sternomastoid ( sm ) muscle after reinnervation with nerve end - to - end anastomosis ( eea ) , which could be used as a baseline for evaluating the efficacy of new reinnervation techniques .
the sm muscle on one side was paralyzed by transecting its nerv... |
excess body weight , from overweight to overt obesity , is associated with adverse health outcomes . in view of the time - trends of the obesity epidemic and the related cost burden ,
the search for effective strategies for weight reduction and long - term maintenance of weight loss ( wl ) is at the top of the agen... | background .
multiple weight loss failures among obese patients suggest the design of new therapeutic strategies .
we investigated the role of 2-week course of enteral treatment with a very low - calorie protein - based formula in the management of severe obesity .
methods .
we evaluated the feasibility , safet... |
elderly people experience rapid physical aging and deterioration of physical function as
they get older1 .
depression in senescence ,
in particular , is known to not only decrease life satisfaction , but to also increase the
potential mortality rate due to increased occurrence rate of physical disease and great... | [ purpose ] this study examined nordic walking as an exercise intervention for the elderly
with depression . [ subjects ] twenty - four patients who were diagnosed with depression were
randomly selected and divided into two groups , an experimental group which performed
nordic walking , and a control group , whic... |
non melanoma skin cancer is 1820 times more frequent than cutaneous malignant melanoma ( mm ) . although mortality from basal cell carcinoma ( bcc ) and squamous cell carcinoma ( scc ) is low but there may be a substantial morbidity from disfigurement as the lesions tend to be located on the skin of the head and neck .... | background : maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion , metastasis , angiogenesis and induce apoptosis.aim:the aim of this work is to investigate maspin expression in cutaneous basal and squamous cell carcinomas by means of immunohistochemistry.material... |
the semibead - like single - crystalline
pt electrodes were purchased
from icryst .
the electrolyte solutions of hclo4 and h2so4 were prepared by hclo4 ( 70% , suprapur ,
merck ) and h2so4 ( 96% , suprapur , merck ) .
the
ultrapure water ( resistivity > 18.2 mcm ) was produced by
a milli - q
gradient a1... | to
understand the interaction between pt and surface oxygenated
species in electrocatalysis , this paper correlates the electrochemistry
of atomic oxygen on pt formed in the gas phase with electrochemically
generated oxygen species on a variety of single - crystal platinum surfaces .
the atomic oxygen adsorbe... |
hemangiopericytoma is a rare tumor , first described in 1942 , mostly composed of pericytes of ramified appearance that are normally found all along the venules and capillaries .
the adult form is most common in the lower extremities , but also occurs in the pelvis or retroperitoneum or other sites .
the developmen... | hemangiopericytoma is a rare tumor , mostly composed of pericytes of ramified appearance that are normally found all along the venules and capillaries .
an 18-year - old female was admitted on march 17 , 1997 to the department of infectious diseases for fever , chills and failure to thrive .
physical examination re... |
we measured drug inhibition of hiv-1 infection using a single round infectivity assay as previously described .
we chose a single round assay because complex factors such as growth and death of target cells distort m in multiround assays . to accurately mimic infection events in vivo
, we carried out infections in ... | highly active antiretroviral therapy ( haart)13 has dramatically decreased mortality from hiv-1 infection4 and is a major achievement of modern medicine . however , there is no fundamental theory of haart .
elegant models describe the dynamics of viral replication3,59 , but a metric for the antiviral activity of drug... |
verrucous hemangioma is a rare variety of angiomatous nevi usually involving the , lower extremities .
it has been reported under a diversity of names such as angiokeratoma circum - scriptum neviforme , unilateral verrucous heman - gioma , keratotic hemangioma etc .
they are best treated by excision while still sma... | a 14-year - girl presented with solitary exuberant warty plaque over her right great toe since the age of 4 years .
ten years ago , an excisional biopsy was performed by a surgeon , and a histopathological diagnosis of angiokeratoma was made .
a wide local excision of the lesion followed by a plantar digital artery... |
most women in menopause report at least one symptom , such as hot flashes , night sweats , or sleep disturbances.1 the prevalence of these symptoms varies widely and is likely to be influenced by a range of factors , including climate , diet , lifestyle , women s roles and attitudes regarding aging , and the end of rep... | backgroundawareness of the risks associated with hormone therapy for menopausal symptoms has sparked a global decline in this treatment .
alternative treatments to relieve menopausal symptoms are therefore required . the applied relaxation ( ar ) technique has proven to be successful for symptom amelioration , but re... |
this study was conducted at a large midwestern academic institution . the pediatric residency program at our institution trains over 40 residents per year , with modules in general pediatrics and combined medicine - pediatric pathways .
the hospital also supports one of the largest nicus in the country , with 168 neo... | objectivepressures on academic faculty to perform beyond their role as educators has stimulated interest in complementary approaches in resident medical education . while fellows are often believed to detract from resident learning and experience , we describe our preliminary investigations utilizing clinical fellows a... |
for decades , scientists have collated data from the collection of semen samples from the world over to establish norms for use by the wider scientific community .
some standardization in the collection process has been guided by the world health organization s various published guidelines for semen management and re... | multiple studies from around the world have suggested that semen quality is declining globally .
however , all studies suffer from variable semen sampling criteria , selection bias with respect to the types of men volunteering to participate , and a bias with respect to a tendency to examine only samples from high - ... |
the prevalence of cardiovascular disease ( cvd ) in rural india is 7.4% , and in urban india , it is 11% .
the incidence of ischaemic heart disease ( ihd ) and coronary heart disease ( chd ) is steadily increasing in the indian subcontinent . according to world health report 2002
this number will represent 54.1% of... | objective .
the objective of this work was to study the risk factors of ischaemic heart disease ( ihd ) in rural populations of the nilgiris , south india , with stress on the various social habits and oxidant stress .
methods . a total of 72 patients with cardiovascular disease ( cvd ) and 12 healthy volunteers we... |
the placement of central venous catheter using seldinger 's technique , though a commonly performed procedure in the intensive care unit , has its own risks and complications .
various complications have been reported with the use of guide wire as well as catheter .
both malposition and entrapment of guidewire are ... | the placement of central venous catheter using seldinger 's technique , remains a commonly performed procedure with its own risks and benefits .
various complications have been reported with the use of guide wire as well as catheter .
we report a unique problem during subclavian vein cannulation due to guidewire ma... |
the food practices of humans are determined by values , attitudes , beliefs , and environmental and religious circumstances ; all of which are the products of tradition , culture , and contacts ( onuorah and ayo , 2003 ) .
knowledge and culture affect the intake of a particular food ( asp , 1999 ) .
the success in ... | the consumption of animal flesh food in ethiopia has associated with cultural practices .
meat plays pivotal and vital parts in special occasions and its cultural symbolic weight is markedly greater than that accorded to most other food . processing and cooking of poultry is a gender based duty and has socio - cultur... |
dereplication of an active etoac - soluble
fraction obtained from
liquid liquid partition of the extract ( 100 mg ) as previously
described indicated that it contained
at least one new bioactive compound , so a larger sample was investigated .
fractionation of this extract yielded an antiproliferative etoac ... | the two new lignans 3-o-(-d - glucopyranosyl)desoxypodophyllotoxin
( 1 ) and
4-o-(-d - glucopyranosyl)dehydropodophyllotoxin
( 2 ) were isolated from cleistanthus boivinianus , together with the known lignans deoxypicropodophyllotoxin ( 3 ) , ( )--apopicropodophyllin ( 4 ) ,
( )-desoxypodophyllotoxin ( 5 ) , ( ... |
shock is a condition in which tissue perfusion is inadequate to maintain the normal oxygen demand .
cardiovascular adaptation during blood loss is under the control of the sympathetic and parasympathetic divisions .
hypotension during hemorrhage is associated with complications such as multiple organ failure , incl... | introduction : different vasoactive factors can modulate cardiovascular adaptation to hemorrhagic shock including nitric oxide ( no ) . in this study we investigated the effect of the no synthase inhibitor for treatment of decompensated hemorrhagic shock in normotensive and hypertensive rats.methods:twenty-four male wi... |
the major causes of morbidity and mortality in western societies have been associated with cardiac hypertrophy and heart failure , which are influenced by several factors [ 1 , 2 ] . in this context , the cardiomyocytes are known to play important role in the adaptation of myocardial structure and function during cardi... | th - induced cardiac hypertrophy in vivo is accompanied by increased cardiac transforming growth factor-1 ( tgf-1 ) levels , which is mediated by angiotensin ii type 1 receptors ( at1r ) and type 2 receptors ( at2r ) .
however , the possible involvement of this factor in th - induced cardiac hypertrophy is unknown . ... |
glaucoma is a group of diseases characterized by chronic progressive optic neuropathy caused by degeneration of retinal ganglion cells and their axons , resulting in the typical appearance of the optic disc , which differentiates it from other optic neuropathies and their visual - field defects [ 14 ] .
there is thin... | backgroundalthough elevated intraocular pressure is a major risk factor for the development of glaucoma , there is increasing evidence that the immune system may be involved in the development of normal - tension glaucoma ( ntg ) .
the aim of this study was to determine if ntg is associated with elevated levels of an... |
mucoepidermoid carcinoma is the most common malignancy of the salivary gland , accounts for about 34% of the malignant epithelial tumor
. more than eight potential variants of mucoepidermoid carcinoma have been introduced , which includes unicystic , sclerosing , oncocytic , clear cell , spindle cell , goblet cell ag... | sclerosing mucoepidermoid carcinoma ( smec ) is extremely rare variant of the mucoepidermoid carcinoma , which is the most common primary malignancy of the salivary glands . as its name suggests ,
smec is characterized by an intense central sclerosis that occupies the entirety of an otherwise typical tumor , frequent... |
there are many studies confirming the presence of helicobacter pylori in the saliva , oral cavity , nose , and mucus of the sinuses,[46 ] middle ear , dental plaques , tonsils , and adenoid glands .
h. pylori has the potential to induce systemic inflammatory reactions through the immunological processes leading to th... | background : helicobacter pylori is capable of inducing systemic inflammatory reactions through immunological processes .
there are several methods to identify the presence of h. pylori in clinical samples including rapid urease test ( rut ) , conventional polymerase chain reaction ( pcr ) , and the scorpion real - t... |
her blood counts were as follows : hemoglobin , 18.2 g / dl ; hematocrit , 55.1% ; platelets , 36110/l ; and leukocytes , 6.8210/l .
serum chemistry values were as follows : creatinine , 0.9 mg / dl ( normal range , 0.5 - 1.3 ) ; albumin , 5.4 g / dl ( 4.0 - 5.2 ) ; ldh , 359 iu / l ( 180 - 460 ) ; alp , 62 iu / l ( ... | a 59-year - old female with diabetes mellitus presented with hypercalcemia and polycythemia .
her serum calcium and intact parathyroid hormone ( ipth ) levels were increased , and tc-99 m sesta - mibi scanning showed hot uptake in the lower portion of the left thyroid lobe .
after parathyroidectomy , her calcium , ... |
breast cancer is the second leading cause of death among women in the united states.1 the increasing use of mammography and increased awareness of breast cancer among women has resulted in early detection of localized breast cancer .
this has led to marked improvement in the cure rate for the disease , which is rapid... | backgroundthe purpose of this study was to evaluate the usefulness of hook wire localization biopsy under imaging guidance for nonpalpable breast lesions detected radiologically.methodsthis was a descriptive study conducted at the department of radiology , aga khan university hospital , karachi .
all patients undergo... |
most tumours are sporadic , but as many as one third occur in the course of the hereditary disorder - von hippel - lindau disease ( vhl ) .
vhl disease is a rare autosomal dominant disorder characterized by a predisposition to hemangioblastomas of the central nervous system ( chab ) and retina , renal cell carcinomas... | central nervous system hemangioblastomas ( chab ) are rare tumours which most commonly arise in the cerebellum .
most tumours are sporadic , but as many as one third of chabs occur in the course of the hereditary disorder - von hippel - lindau disease ( vhl ) . in order to diagnose new vhl families in poland we perfo... |
the sedatives and analgesics used during anesthetic procedures are known to produce undesirable effects on cardiac hemodynamics .
but there is no other diagnostic test to evaluate this emergency situation except a meticulous clinical observation of sustained hypotension with tissue hypoperfusion despite adequate left... | the intravenous administration of propofol and fentanyl has become a common practice in a variety of clinical settings including outpatient dermatologic , cosmetic and oral surgery .
the combination provides both systematic sedation and analgesia with low incidence of unwanted side effects .
the cardiogenic shock i... |
primary cardiac lymphoma ( pcl ) is a rare malignancy.1)2 ) furthermore , bi - atrial involvement is extremely rare , and most of the previous cases have been b - cell lymphomas.3 ) we report here a case of pcl with involvement of both atria and the atrial septum .
a 63 year old female without any previous medical hi... | we described here a patient who presented with symptoms of heart failure who was found to have severe bilateral impairment of atrioventricular inflow .
primary cardiac lymphoma ( pcl ) with extensive involvement of the two atria , pericardium and myocardium is an extremely rare tumor in immunocompetent patients .
w... |
a 34-year - old woman with obesity ( height , 150 cm ; weight , 65 kg ; and body mass index , 28.8 kg / m ) and a short neck ( fig .
1 ) suddenly developed dyspnea , seizure , and drowsy change of mental status and was transferred to our hospital for management .
her diagnosis was spontaneous subarachnoid hemorrhag... | we report a difficult case of tracheostomy in a 34-year - old obese woman with a short neck .
the tracheostomy tube placement repeatedly failed because of anatomical changes due to obesity and a short neck , tracheal mucosal swelling due to prolonged intubation , and unexpected false passage ; however , it was succes... |
cleidocranial dysplasia ( ccd ) is a rare developmental disease with skeletal dysplasia and is considered to be of autosomal dominant inheritance ( 1 ) .
individuals with ccd are typically of short stature , with brachycephalic skull and bossing of the parietal and frontal bones ( 2 ) .
hypoplasia of the mid - face... | cleidocranial dysplasia ( ccd ) is a rare autosomal dominant condition that affects ossification .
the dental abnormalities associated with ccd present an obstacle to orthodontic treatment planning .
early diagnosis is crucial to provide the patient with different treatment modalities that will suit the particular ... |
recent developments in optical coherence tomography ( oct ) technology have now enabled clinicians to visualize vascular flow within the retina and choroid and around the optic disc [ 1 , 2 ] .
optical coherence tomography angiography ( octa ) detects blood flow by analyzing signal decorrelation or phase deviations b... | purpose . to describe a novel technique of adapting a swept - source optical coherence tomography angiography ( octa ) to image corneal vascularization
. methods . in this
pilot cross - sectional study , we obtained 3 3 mm scans , where 100,000 a - scans are acquired per second with optical axial resolution of 8 ... |
gestational diabetes mellitus ( gdm ) occurs in 25% of all pregnancies and is known to be associated with poor maternal and fetal outcomes . apart from being implicated as a risk factor for future type 2 diabetes in the mother
, gdm also leads to several adverse fetal outcomes such as macrosomia , shoulder dystocia a... | aim : to compare the existing maternal and fetal outcomes in asian indian women with or without gestational diabetes mellitus ( gdm ) before the development of the women in india with gdm strategy ( wings ) gdm model of care ( moc).materials and methods : records of pregnant women were extracted retrospectively from th... |
the occurrence and progression of nervous system injury and related diseases is a process involving changes in synapse number , structure and function . therefore , the effective regulation of synapse formation and function is important for the treatment of nervous system diseases .
recent evidence indicates that ast... | here , we review research on the mechanisms underlying the ability of thrombospondin to promote synaptogenesis and examine its role in central nervous system diseases and drug actions .
thrombospondin secreted by glial cells plays a critical role in synaptogenesis and maintains synapse stability .
thrombospondin re... |
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