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acute liver failure ( alf ) is a clinical syndrome , in which there is an acute insult in a patient without a known preexisting liver disease that leads to a rapid loss of liver function , characterized mainly by hepatic encephalopathy ( he ) , jaundice and coagulopathy .
the prognosis of these patients was very poor... | previous retrospective study ( 1992 to 2000 ) performed in spain showed that drug toxicity , viral hepatitis , and indeterminate etiology were the most prevalent causes of acute liver failure ( alf ) . in the last decade
, there is no information about alf in our country . for these reasons we analyze retrospectively... |
agenesis of one or more teeth in primary or permanent dentition is known as hypodontia , while , hyperdontia is a condition that of having extra to the normal complement of teeth .
the occurrence of both these identities in the same individual is a form of combined numeric variation .
although , the existing litera... | dental anomalies of tooth number in development of the permanent dentition are quite common than the primary dentition , however , the combined occurrence of hypodontia and hyperdontia is a rare phenomenon , especially in the same dental arch .
the purpose of this report is to describe a case of concomitant hypo - hy... |
sebaceous cysts often known as epidermal cysts result from folding of the squamous epithelium beneath the epidermis .
etiology of vulval sebaceous cyst is unknown , however , they are known to occur due to obstruction of the pilo sebaceous ducts and gland or secondary to trauma like episiotomy , perineal tear or fema... | vulval swellings have always caused dilemmas in diagnosis and more so when they are huge in size .
sebaceous cysts are known to occur as a result of blocked pilo - sebaceous gland and duct or as a result of any injury to the skin .
face , neck , chest , back , scalp , and ears are known sites , however , they also ... |
new technological innovations have contributed to profound changes in the quality of life of human beings and societal changes .
while each job has its own stress , the fast and relentless pace of technology - enhanced work environment in it has created new culture .
two healthy software engineers subjected themsel... | snake venom use for recreational purposes has been documented earlier . willfully subjecting oneself to repeated lethal snake bite as a source of getting relieved of stress and recreation observed in two healthy software engineers , without any underlying psychiatric ailments or comorbidities along with probable mechan... |
participants in the aric study were recruited from four united states communities : washington county , maryland ; suburbs of minneapolis , minnesota ; forsyth county , north carolina ; and jackson , mississippi .
the first examination of 15,792 participants took place from 1987 to 1989 ( visit 1 ) , when participant... | objectiveto examine the association between diabetes , glycemic control , and risk of fracture - related hospitalization in the atherosclerosis risk in communities ( aric ) study.research design and methodsfracture - related hospitalization was defined using international classification of diseases , 9th revision , cod... |
xeroderma pigmentosum ( xp ) is a rare autosomal recessive disorder characterized by sun sensitivity , photophobia , early onset of freckling , and subsequent neoplastic changes on sun - exposed skin .
seven xp complementation groups ( xpa to xpg ) , as well as variant ( xpv ) , have been revealed .
xpa through xpg... | xeroderma pigmentosum - variant ( xpv ) is one type of xp , a rare autosomal recessive disorder , and caused by defects in the post replication repair machinery while nucleotide - excision repair ( ner ) is not impaired . in the present study , we reported a chinese family with xpv phenotype , which was confirmed by hi... |
a(142 ) was synthesized
and purified as previously described using solid - phase synthesis with
standard fmoc synthesis and cleavage protocols as well as hplc purification .
the ssnmr experiments were performed following the established
procedures used for amyloid intermediates of a(140 ) .
all of the ssnmr e... | accumulating
evidence suggests that various neurodegenerative
diseases , including alzheimer s disease ( ad ) , are linked to
cytotoxic diffusible aggregates of amyloid proteins , which are metastable
intermediate species in protein misfolding .
this study presents the
first site - specific structural study... |
since the introduction of the acid - etch bonding technique several decades ago , orthodontists have successfully and reliably employed fixed appliances in clinical practice .
orthodontic light - cured adhesive materials have had additional advantages over previously used adhesives , including simplicity of use and i... | objectivethis study evaluated the cytotoxicity and genotoxicity of fixed orthodontic treatment with three different light - cured orthodontic bonding composites by analyzing micronucleus ( mn ) formation in the buccal mucosa during a 6-month period.methodsthirty healthy volunteers were selected from consecutive patient... |
chronic positive energy balance through inadequate dietary habits and a sedentary life style leads to an excessive accumulation of body fat , known as obesity , the prevalence of which is increasing alarmingly worldwide .
obese individuals have a greater risk for the development of many chronic and highly incident di... | palmitoleic acid ( pma ) has anti - inflammatory and antidiabetic activities . here
we tested whether these effects of pma on glucose homeostasis and liver inflammation , in mice fed with high - fat diet ( hfd ) , are ppar- dependent . c57bl6
wild - type ( wt ) and ppar--knockout ( ko ) mice fed with a standard die... |
vasoactive intestinal peptide ( vip ) is a 28-amino acid peptide belonging to the secretin family .
it is co - synthesised from a vip pro - peptide which also contains a sequence for peptide histidine isoleucine ( nishizawa et al .
1995 ) , although in humans isolecine is replaced by methionine to form peptide hist... | vasoactive intestinal peptide ( vip ) is a pleiotropic , highly conserved , peptide found in many different biological systems throughout invertebrate phyla .
vip is produced by cells of the immune system but also inhibits many different inflammatory products produced by these immune cells , including cytokines and c... |
this discussion will examine the evolution of digital pathology to embrace all forms of computational imaging , with a consideration of possible impediments for the availability of this technology for diagnostic and experimental pathology .
one such impediment is a lack of awareness by pathologists of many of the new... | the digitization of images has not only led to increasingly sophisticated methods of quantitating information from those images themselves , but also to the development of new physics - based techniques for extracting information from the original specimen and presenting this as visual data in both two and three - dime... |
levosimendan is a pharmacological agent that exerts positive inotropic effect by binding to cardiac troponin c in a calcium - dependent manner and sensitizing myofilaments to calcium without increasing myocardial oxygen consumption [ 13 ] .
levosimendan also has vasodilatory properties through its facilitation of an ... | summarybackgroundacute decompensation heart failure ( adhf ) remains a cause of hospitalization in patients with end - stage congestive hf .
the administration of levosimendan in comparison with a standard therapy in chf patients admitted for adhf was analysed.material/methodsconsecutive patients admitted for adhf ( ... |
ct scans of the pelvis and femur with 1.5 mm slice thickness were performed before each surgery .
ct data were transferred to 3d template software ( zedhip ; lexi co. , tokyo , japan ) in digital imaging and communications in medicine ( dicom ) format to create a 3d bone model .
the 3d - shape data created were con... | rotational acetabular osteotomy ( rao ) is a well - established surgical procedure for patients with acetabular dysplasia , and excellent long - term results have been reported .
however , rao is technically demanding and precise execution of this procedure requires experience with this surgery .
the usefulness of ... |
square jaw refers to an enlarged masseter muscle , along with an increased bony growth in the mandibular angle area . in general ,
masseter muscle hypertrophy appears and is characterized by sleep bruxism symptoms , etc . in most cases ,
square jaw is associated with masseter muscle hypertrophy in the caucasian , w... | a patient , who underwent partial masseter muscle resection and mandibular angle reduction at a plastic surgery clinic , visited this hospital with major complaints of trismus and dysesthesia .
a secondary angle formation due to a wrong surgical method was observed via clinical and radiological examinations , and the... |
concurrence of migraine and hallucinations is extremely rare and the underlying mechanism is poorly understood .
we report a 22-year - old man with migraine associated with auditory hallucinations . concurrent psychotic illness has been excluded .
brain mr scans showed a stable , patchy flair hyperintensity over th... | backgroundconcurrence of migraine and hallucinations is extremely rare and the underlying mechanism is poorly understood.methodswe report a 22-year - old man with migraine associated with auditory hallucinations .
concurrent psychotic illness has been excluded.resultsbrain mr scans showed a stable , patchy flair hype... |
diabetes mellitus ( dm ) as a major independent risk factor of micro- and macro - vascular complications is preceded by abnormal but reversible condition namedasimpaired fasting glucose ( ifg ) .
overt dm is considered as mainspring strong primary and secondary risk factor of ischemic heart disease ( ihd ) andis resp... | aims : to detect the risk factors of diabetes mellitus ( dm ) and cardiovascular complications in subjects with impaired fasting glucose ( ifg).materials and methods : one hundred and twenty three subjects with proved ifg in zanjan healthy heart study ( 2002 - 2003 ) were recalled and participated in this study ( 2009 ... |
the mortality associated with observation has been reported to be as high as 27% ( 1 ) .
paraoesophageal hernias have been repaired through the abdomen and through the chest ( 2 ) .
laparoscopic repair has become the gold standard for smaller hernias , but the high recurrence rates associated with laparoscopic repa... | open primary transthoracic repair is a well established treatment for large paraesophageal hernias .
the rate of major post - operative complications has been reported to be low , and no cases of acute diaphragmatic injury have previously been reported . here
we present a case of open primary transthoracic repair o... |
the genetic basis of drug effects is the pharmacodynamic domain of the pharmacogenomics of antidepressants .
there has been considerable research in this area , with variable and sometimes contradictory results . as the body of evidence increases , some trends and findings
become more solidly established , while ot... | there has been considerable promise and hope that pharmacogenomics will optimize existing treatments for major depression , as well as identify novel targets for drug discovery . immediately after the sequencing of the human genome , there was much hope that tremendous progress in pharmacogenomics would rapidly be achi... |
edentulous patients seeking dental treatment to restore function and aesthetic appearance have traditionally received removable complete or partial dentures . however
, the use of removable dentures may lead to a sense of patient insecurity , reduced chewing capacity and taste and low self - esteem .
thus , the way... | background : short implants are manufactured for use in atrophic regions of the jaws . although many studies report on short implants as 10 mm length with considerable success , the literature regarding survival rate of 7 mm is sparse.purpose:the purpose of this study was to systematically evaluate the publications con... |
they comprise a number of inflammatory and infectious conditions caused by the inflammatory host response to bacteria in the supragingival and subgingival biofilm .
the presence of periodontal pathogens may lead to an imbalance in the periodontal environment , and the subsequent host innate and adaptive immune respon... | periodontitis is a multifactorial disease , with participation of bacterial , environmental , and host factors .
it results from synergistic and dysbiotic multispecies microorganisms , critical keystone pathogens , affecting the whole bacterial community .
the purpose of this study was to review the role of porph... |
our primary objective was to investigate whether an mdi regimen using insulin glargine as basal insulin with insulin lispro at mealtimes can achieve glycemic control ( a1c ) equivalent to csii ( insulin lispro ) in people with type 1 diabetes .
secondary objectives were to compare other measures of blood glucose cont... | objectiveinsulin pump therapy ( continuous subcutaneous insulin infusion [ csii ] ) and multiple daily injections ( mdis ) with insulin glargine as basal insulin and mealtime insulin lispro have not been prospectively compared in people nave to either regimen in a multicenter study .
we aimed to help close that defic... |
we tested for human - specific relaxation of constraint among groups of functionally related genes using three criteria : 1 ) genes in a group should have low levels of mammalian protein sequence divergence but relatively high human nonsynonymous diversity , 2 ) that the group should have higher human nonsynonymous div... | environmental or genomic changes during evolution can relax negative selection pressure on specific loci , permitting high frequency polymorphisms at previously conserved sites . here
, we jointly analyze population genomic and comparative genomic data to search for functional processes showing relaxed negative selec... |
a total of 278 hcc patients , who underwent curative surgery at korea university guro hospital between 2000 and 2013 were enrolled in this study .
all hematoxylin and eosin stained slides were reviewed . to classify the pathologic staging , the american joint committee on cancer ( ajcc ) staging system ( seventh edi... | backgroundsirt7 is one of the histone deacetylases and is nad - dependent .
it forms a complex with ets - like transcription factor 4 ( elk4 ) , which deacetylates h3k18ac and works as a transcriptional suppressor .
overexpression of sirt7 and deacetylation of h3k18ac have been shown to be associated with aggressiv... |
these molecules , which are typically 22 nucleotide long , are produced from larger precursors that contain approximately 70 nucleotides , by enzymes belonging to the argonaute family and the rnase iii , dicer .
after incorporation of mir into the rna - induced silencing complex ( risc ) , suppression of the translat... | multiple mechanisms are implicated in the development of primary osteoarthritis ( oa ) , in which genetic and epigenetic factors appear to interact with environmental factors and age to initiate the disease and stimulate its progression .
changes in expression of micrornas ( mirs ) contribute to development of osteoa... |
the term osteoid osteoma was first coined by jaffe in 1935 to describe a lesion previously known by a variety of names .
osteoid osteoma is a small spherical tumor with a diameter of 1.5 cm or less , composed of a central zone named nidus which is an atypical bone completely enclosed within a well - vascularized str... | osteoid osteomata are rarely found in the distal phalanges of the hand .
the usual presenting features are chronic pain , nail enlargement and increase in size of the terminal part of the digit .
diagnosis is difficult but surgical excision is effective for treating the patients pain .
we reported this tumor in d... |
vertebral fracture is the most common type of osteoporotic fracture and imposes a significant burden on society . in the year 2000
such fractures can cause disabling pain and kyphotic deformity leading to impaired physical function and reduced quality of life [ 3 , 4 ] . for a significant number of patients t... | osteoporotic vertebral fractures often lead to pain and disability
. they can be successfully treated , and possibly prevented , by injecting cement into the vertebral body , a procedure known as vertebroplasty .
kyphoplasty is similar , except that an inflatable balloon is used to restore vertebral body height bef... |
hypoxic ischemic encephalopathy ( hie ) is a devastating event , which is a major cause of mortality and morbidity in newborns .
it is important to elicit the maturity of the neonate and the duration and severity of the insult because the pattern of injury varies .
the pattern of brain injury on magnetic resonance... | background : restricted diffusion within the splenium of the corpus callosum has been described by other authors in various conditions , however , restricted diffusion in the entire corpus callosum or isolated involvement of the splenium , genu , or body has been infrequently reported on magnetic resonance imaging ( mr... |
a 48-year - old male visited department of orthopedic surgery , chungnam national university hospital complaining of right anterior thigh pain beginning six months prior without any history of trauma .
he had begun having pain in the right inguinal area and difficulty in crossing his legs on the floor beginning six m... | subchondral bony cyst , large solitary or multiple cysts in acetabular dome usually exacerbate progression to degenerative osteoarthritis in the hip joint . but it can be treated through arthroscopic intervention .
we report two cases that treated by arthroscopic curettage and bone graft for subchondral bony cysts in... |
this process commences immediately after injury and is composed of the following three main phases : inflammatory , proliferative , and maturation .
the wound - healing process is not linear , and these phases depend on various intrinsic and extrinsic factors .
several factors may influence the healing process , in... | patients who have suffered burns frequently experience psychological consequences , among which anxiety disorders are prominent .
benzodiazepines are commonly administered to treat these symptoms .
the effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep archi... |
the lahan eye hospital is a busy hospital where only few ophthalmologists sometimes need to perform 300 - 400 cataract operations per day .
therefore there was need for a straightforward , fast , easy - to - learn and safe technique to achieve excellent results .
the required anterior chamber ( ac ) maintainer and ... | the fishhook technique developed at the lahan eye hospital is widely used in nepal and other countries .
its specialty is the extraction of the nucleus with a bent 30-g needle ( fishhook ) out of the capsular bag and the self - sealing tunnel .
all sizes of nuclei can be extracted .
the fishhook technique has a s... |
ependymomas constitute 2 - 9% of all intracranial neoplasms . of these , about 50% present within the first two decades .
cerebrospinal fluid ( csf ) spread is seen in about 8 - 33% of patients with ependymoma at presentation , and is more common in patients with infratentorial tumors ( 9.7% ) than in those with supr... | ependymoma is one of the uncommon tumors of the central nervous system ( cns ) in the adult age group .
these tumors have a distinct propensity for metastasis , both within and outside the cns . however , dissemination at the time of first presentation and retrograde dissemination of the tumor is rare .
we report t... |
central serous chorioretinopathy ( csc ) is characterized by a neurosensory retinal detachment in the posterior fundus associated with one or more leaks at the level of the retinal pigment epithelium ( rpe ) .
etiology of leakage is unclear but thought to be related to hyperpermeability of the choroidal vasculature .... | purpose . to describe topographical changes in choroidal thickness as measured by optical coherence tomography following photodynamic therapy ( pdt ) for central serous chorioretinopathy ( csc )
. methods . case report . results . by 1 month following pdt , mean ( sd ) choroidal thickness decreased from 562 microns (... |
cranial nerve palsies can result as a complication of posterior fossa procedures involving or adjacent to the brain stem .
a number of case reports in the literature have described multiple cranial nerve palsies secondary to neurosurgical interventions with resultant brain stem injury [ 1 , 2 ] .
we report a rare c... | multiple cranial nerves palsies following a posterior fossa exploration confined to an extradural compartment is a rare clinical presentation .
this case report describes a young man who developed a unilateral abducens and bilateral facial nerve palsies following a posterior fossa exploration confined to an extradura... |
osteoarthritis ( oa ) which is a major cause of disability among elderly population is a major cause of a burden on the health system in the western world , and its incidence and prevalence continues to rise with a rapidly increasing aging population .
oa occurs due to an interaction between certain systemic and loca... | background : performing successful total hip replacement ( thr ) in dysplastic , subluxed , and dislocated hip is a challenging task . here ,
we assessed midterm clinical and radiological outcomes of uncemented total hip arthroplasty in osteoarthritis ( oa ) of hip secondary to hartofilakidis low and high - dislocate... |
leukemia and lymphoma
account for approximately 9% of new cancer cases diagnosed in the
united states each year .
chronic lymphocytic
leukemia ( cll ) , the most common lymphoid neoplasia , progresses rapidly
in two - thirds of diagnosed patients with a relatively poor prognosis .
chemotherapy
treatments ... | chronic
lymphocytic leukemia ( cll ) is the most common lymphoid neoplasia in
western societies and is currently incurable .
multiple treatment options
are practiced , but the available small molecule drugs suffer from
dose - limiting toxicity and undesirable side effects .
the need for
new , less toxic t... |
this review will discuss the anatomy , equipment , adverse events and outcome measures of occipital nerve stimulation ( ons ) trials , with an emphasis on the clinical utility of implantable neurostimulation devices in the treatment of chronic migraine .
headache disorders are a worldwide problem , affecting people o... | chronic migraine is a disabling disorder that is costly to individuals and society .
occipital nerve stimulation has been used to treat refractory cases of primary headache disorders including drug - resistant chronic cluster headaches and chronic migraine .
the food and drug administration ( fda ) off - labeled ap... |
obesity is one of the most important concerns of the 21st century , and it is considered to be a major public health issue worldwide . morbid obesity defined as body mass index ( bmi ) over 40 kg / m represents a stage in which lifestyle changes , diet and pharmaceutical agents fail to obtain and sustain a significant ... | background and aimmorbid obesity represents a proinflammatory and pro - oxidative state associated with dysregulation of adipokines .
we aimed to evaluate the circulating levels of chemerin and omentin-1 in morbidly obese ( mo ) patients and to investigate the relationship between these two adipokines and between eac... |
the low pathogenic avian influenza h9n2 virus is a candidate of threat to human health .
the primary target for h9n2 virus is the epithelial lining of the respiratory tract where the viral surface protein hemagglutinin ( ha ) binds to terminal sialic acid - capped glycosylated cellular receptors and cleaves by cellul... | background : limited knowledge about the molecular mechanism of avian influenza h9n2 virus pathogenicity in birds as well as human hosts has limited the development of effective control against the disease . to overcome this issue detailed understanding of the infectious characteristics of the virus in host cells shoul... |
aging , at the whole organism scale , is a very complex process , involving many different mechanisms . studying the normal senescence process is also complex as we are permanently surrounded by pathogens , have different lifestyle habits , and exposed to different levels of stress which all influence the senescence pr... | nk cells exhibit the highest cytotoxic capacity within the immune system .
alteration of their number or functionality may have a deep impact on overall immunity .
this is of particular relevance in aging where the elderly population becomes more susceptible to infection , cancer , autoimmune diseases , and neurode... |
immunization remains one of the most important public health interventions and a cost - effective strategy to reduce both the morbidity and mortality associated with infectious diseases . over two million deaths
are delayed through immunization each year worldwide . despite this , vaccine - preventable diseases remai... | background : immunization remains one of the most important public health interventions and a cost - effective strategy to reduce both the morbidity and mortality associated with infectious diseases . over two million deaths are delayed through immunization each year worldwide.aims:this study sought to identify specifi... |
the retina is unique in its specialisation for the capture of light and transduction into an electrical signal .
effective phototransduction and signal transmission involves many processes that are energetically expensive , including the maintenance of transmembrane ionic gradients , signal amplification , and neurot... | intraocular pressure ( iop ) elevation is a key risk factor for glaucoma .
our understanding of the effect that iop elevation has on the eye has been greatly enhanced by the application of the electroretinogram ( erg ) . in this paper , we describe how the erg in the rodent eye is affected by changes in iop magnitude... |
patients in intensive care units ( icus ) are highly transfused , with one - third of icu patients transfused and 50% of mechanically ventilated patients receiving at least one transfusion .
the prevalence of transfusion is lower in injured patients , with 9% of trauma patients transfused and 2% massively transfused ... | blood transfusion is frequent in critical care .
transfusion raises the mass of transfused blood components and is lifesaving in acute hemorrhage . in massive transfusion ( > 10 units of red blood cells ) ,
early attempts to restore coagulation function appear helpful .
transfusion in non - bleeding patients is l... |
new - onset atrial fibrillation is the most common form of rhythm disturbance following heart surgery .
the incidence of postoperative atrial fibrillation ( poaf ) in patients after coronary artery bypass grafting surgery ( cabg ) varies from 20% to 35% .
poaf most commonly occurs between the second and the fourth ... | summarybackgroundnew - onset atrial fibrillation is the most common form of rhythm disturbance following coronary artery bypass grafting surgery ( cabg ) .
it is still unclear which factors have a significant impact on its occurrence after this procedure .
the aim of this study was to evaluate clinical predictors o... |
idiopathic central precocious puberty ( cpp ) is defined as development of secondary sex characteristics before the age of 8 in girls and 9 in boys due to early activation of gonadotropin - releasing hormone ( gnrh)-secreting neurons without the presence of an organic reason .
gnrh agonist therapy used in the treatme... | objective : the study aimed to assess the effect of gonadotropin - releasing hormone ( gnrh ) agonist therapy on body mass index ( bmi ) and growth in girls diagnosed with idiopathic central precocious puberty ( cpp).materials and methods : hospital records of 32 girls with idiopathic cpp who have been receiving gnrh a... |
while the genome sizes of multicellular eukaryotes are generally larger and more variable in length than those of prokaryotes , guanine and cytosine ( gc ) content exhibits a much smaller variation in eukaryotes than in prokaryotes .
in particular , vertebrate genomes show quite a uniform gc content , distributing ov... | eukaryotic genomes , particularly animal genomes , have a complex , nonuniform , and nonrandom internal compositional organization .
the compositional organization of animal genomes can be described as a mosaic of discrete genomic regions , called compositional domains , each with a distinct gc content that signifi... |
acute exercise has a marked effect on the immune system response . increased neutrophil , monocyte , and lymphocyte concentration have been reported following prolonged exercise,1 moderate intensity walking,2 and shortterm swim exercise.3 two hours of cycling at 55% vo2peak significantly increased neutrophil degranulat... | objective : the purpose of this investigation was to determine whether cognitive awareness of carbohydrate beverage consumption affects exerciseinduced lymphocyte apoptosis , independent of actual carbohydrate intake.introduction:carbohydrate supplementation during aerobic exercise generally protects against the immuno... |
pneumatosis intestinalis ( pi ) is the presence of gas within the wall of the gastrointestinal tract and is not a diagnosis but a radiographic finding that results from an underlying pathologic process .
therefore , pi represents a tremendous spectrum of conditions and outcomes , ranging from benign diseases to abd... | pneumatosis intestinalis ( pi ) is the presence of gas within the wall of the gastrointestinal tract and represents a tremendous spectrum of conditions and outcomes , ranging from benign diseases to abdominal sepsis and death .
it is seen with increased frequency in patients who are immunocompromised because of stero... |
the legs with pain and paresthesia are frequently reported problems of patients who visit a clinical office of family physician .
one of the highly possible diseases is an acute lower limb ischemia from inappropriate blood flow .
prompt diagnosis and revascularization can lead to limb salvage , whereas delayed reco... | an ischemic foot can be developed by acute arterial occlusion . given proper treatment within critical time ,
the patient can avoid foot amputation and death .
early proper diagnosis and treatment by family physician at the initial clinical interviewing is important in saving the affected leg and the life .
throm... |
according to a world health organization ( who ) report , cardiovascular diseases ( cvds ) are the number one cause of death globally . it was estimated that 17.3 million people died from cvds in 2008 , representing 30% of all global deaths .
in addition , it is predicted that almost 23.6 million people will die from... | the contribution of stem cells to cure damaged hearts has finally been unraveled .
a large number of preclinical and clinical studies have showed beneficial outcomes after myocardial infarction . in this review , the current understanding of stem cell therapy in preclinical and clinical experiences is summarized .
... |
odonate larvae were sampled by kick seine in june and july of 2013 , in little creek on the furman university campus in greenville county , sc ( 34 55.26 n , 82 26.07 w , elevation : 330 m ) .
little creek is a first order stream originating approximately 2 km upstream on paris mountain ( elevation : 640 m ) , a m... | dragonfly larvae were sampled in little creek , greenville , sc .
the distributions of five common species were described relative to sediment type , body size , and the presence of other larvae . in total ,
337 quadrats ( 1 m by 0.5 m ) were sampled by kick seine . for each quadrat ,
the substrate was classifi... |
transhiatal esophagectomy with cervical esophagogastrostomy was performed for early distal esophageal cancer because of severe adhesion in the right thoracic cavity due to the tuberculous destruction of the right upper parenchymal area .
the hiatal opening was four finger widths , and crus division was performed only... | diaphragmatic hernia was found in a patient who had undergone transhiatal esophagectomy for early esophageal cancer .
chest x - ray was not helpful , but abdominal or chest computed tomography was useful for accurate diagnosis .
primary repair through thoracotomy was performed and was found to be feasible and effec... |
a 75-year - old female was referred to our clinic with bilateral adrenal masses that were detected incidentally by lumbar spine magnetic resonance imaging ( mri ) for evaluation of radiating flank pain .
she presented with a high blood glucose level that had been controlled with medical treatment for 10 years .
she... | a 75-year - old female visited our hospital with bilateral adrenal masses that were detected incidentally during lumbar spine magnetic resonance imaging ( mri ) for the evaluation of radiating flank pain .
consecutive computed tomography and mri revealed bilateral adrenal masses with no evidence of lymph node enlarge... |
for many years there have been discussions in the literature relating to the stability of gadolinium ( gd)-based contrast agents ( gbcas ) . the recent focus on the rare , but very serious disorder
nephrogenic systemic fibrosis ( nsf ) , characterised by fibrosis of the skin and other tissues throughout the body , ha... | objectivethe biodistribution of gadolinium ( gd ) and chelate was studied in rats injected intravenously with a commercially available gadodiamide magnetic resonance contrast agent spiked with trace amounts of 14c - labelled gddtpa-bma.methodsbiodistribution of the 14c - labelled ligand in whole animals was visualised ... |
seven years after the discovery of the natriuretic factor from the atria of the heart ( anf ) [ 1 , 2 ] and five years after the first purification and sequencing of its circulating form , brain natriuretic peptide ( bnp ) was isolated from porcine brain . subsequently , bnp was found to be most abundantly expressed in... | gene expression and secretion of the cardiac polypeptide hormones atrial natriuretic factor ( anf ) and brain natriuretic peptide ( bnp ) are simultaneously upregulated in various cardiac disorders such as congestive heart failure , ischemic heart disease , and hypertensive heart disease , in which hemodynamic or neuro... |
the unique properties
of carbon nanotubes ( cnts ) and the possibility
to implement them in various applications have made them attractive
for researchers in the last two decades . despite the huge number of
studies on cnts ,
, some
progress has been made to selectively postpurify single - walled carbon
n... | we report on a dip - coating method to prepare catalyst
particles
( mixture of iron and cobalt ) with a controlled diameter distribution
on silicon wafer substrates by changing the solution 's concentration
and withdrawal velocity .
the size and distribution of the prepared
catalyst particles were analyzed ... |
preparation for performances such as jumping , acceleration , speed , agility , and others , should involve both long and short - term training programs .
long - term preparation may include a well - developed fitness training program , whereas short - term preparation should include a warm - up ( amiri - khorasani e... | abstractthe purpose of this study was to investigate the acute effect of different stretching methods , during a warm - up , on the acceleration and speed of soccer players .
the acceleration performance of 20 collegiate soccer players ( body height : 177.25 5.31 cm ; body mass : 65.10 5.62 kg ; age : 16.85 0.87 y... |
autoimmune diseases are typically multietiological entities , where genetic and environmental abnormalities along with derailed immunoregulatory processes contribute to the development of disease . in the healthy immune system ,
various tolerance mechanisms , such as activation - induced cell death , anergy , or clon... | autoimmune processes can be found in physiological circumstances .
however , they are quenched with properly functioning regulatory mechanisms and do not evolve into full - blown autoimmune diseases .
once developed , autoimmune diseases are characterized by signature clinical features , accompanied by sustained ce... |
although il-4 was discovered by bill paul s group in 1982 as a factor that promoted b cell proliferation ( howard et al . , 1982 ) , it ( and the related cytokine il-13 ) came to prominence as regulatory and effector cytokines critical to the biology of th2-polarized immune responses that are important both in protecti... | macrophages play pleiotropic , niche - specific roles in all tissues and organs . as immune sentinels ,
tissue macrophages regulate immune activation and inflammation ; in turn , their function is modulated by inflammatory mediators deriving from such activation .
recent papers have established unanticipated roles ... |
individual response to drugs often differs significantly and these drug - response variations are frequently associated with polymorphisms of pharmacologically related proteins ( 15 ) .
pharmacogenetic study of these proteins and their regulatory sites is important for the understanding of molecular mechanism of drug... | prediction and elucidation of pharmacogenetic effects is important for facilitating the development of personalized medicines .
knowledge of polymorphism - induced and other types of drug - response variations is needed for facilitating such studies .
although databases of pharmacogenetic knowledge , polymorphism a... |
williams syndrome ( ws ) is a rare neurodevelopmental disorder caused by a hemizygous deletion of 2530 genes on chromosome band 7q11.23 ( ewart et al .
1993 ) and associated with atypical social and cognitive profiles . perhaps the most noted , albeit relatively little systematically investigated aspect of the ws beh... | one of the most compelling features of williams syndrome ( ws ) is the widely reported excessive sociability , accompanied by a relative proficiency in expressive language , which stands in stark contrast with significant intellectual and nonverbal impairments .
it has been proposed that the unique language skills ob... |
coronary artery disease ( cad ) is a very common health problem in the developed as well as developing countries .
acute myocardial infarction ( ami ) is one of the leading causes for death worldwide , and it is the single largest cause of death in the united states , responsible for 1 out of every 6 deaths [ 1 , 2 ]... | rapid and correct diagnosis of acute myocardial infarction ( ami ) plays a crucial role in saving patients ' life .
although some biomarkers ( such as cardiac troponin and creatine kinase ) are available for ami diagnosis so far , there is still a clinical need for novel biomarkers , which can reliably rule in or rul... |
introduction of contrast agents in ultrasound medical imaging has strongly improved the image contrast leading to a better medical diagnosis [ 13 ] . by adapting the transmitting ultrasound sequences composed of short wave trains to longer sinusoidal wave trains , it has been possible to enhance the harmonics detection... | sub- and ultraharmonic ( suh ) ultrasound contrast imaging is an alternative modality to the second harmonic imaging , since , in specific conditions it could produce high quality echographic images .
this modality enables the contrast enhancement of echographic images by using suh present in the contrast agent respo... |
elastography can better differentiate benign from malignant testicular lesions follow up can be reduced for elastic testicular lesions at elastography .
until the advent of b - mode ultrasound , diagnosis of scrotal lesions relied on palpation and their characterisation was based on the detection of changes in tissu... | objectivesto assess the ability of real - time elastography ( rte ) to differentiate malignant from benign testicular lesions.methodsin 88 testicles ultrasound identified 144 lesions , which were examined by rte .
elasticity images of the lesions were assigned the colour - coded score of itoh ( radiology 2006 ) , acc... |
although approximately 200 cases of appendiceal intussusception have been reported in the literature , very few have ever been diagnosed preoperatively .
we report a case of appendiceal intussusception secondary to endometriosis in an otherwise healthy female and review the literature regarding this rare finding .
... | intussusception of the appendix is an extremely rare condition .
although approximately 200 cases of appendiceal intussusception have been reported in the literature , very few have ever been diagnosed preoperatively .
we report a case of appendiceal intussusception secondary to endometriosis in an otherwise health... |
numerous cases of acute and chronic pulmonary conditions are accompanied by extravasation of erythrocytes to the lower respiratory tract ( lung hemorrhage ) .
these pathological events are frequently associated with marked leukocyte influx and an increase in inflammatory markers [ 17 ] . in cases of moderate to inten... | clinical and experimental observations have supported the notion that free heme released during hemorrhagic and hemolytic episodes may have a major role in lung inflammation . with alveolar macrophages ( am ) being the main line of defense in lung environments ,
the influence of free heme on am activity and function ... |
a global 10-year effort by the international knockout mouse consortium ( ikmc ) to create targeted knockout strains for every gene in the mouse genome ( 20,000 ) is now well underway .
this ambitious scheme will create an unparalleled resource for uncovering the role of individual genes in maintaining normal physiolo... | summaryinternational efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised .
these homozygous lethal mutants represent a potential treasure trove for the biomedical community .
developmental biologists could exploit t... |
the middle range theory of resourcefulness is grounded in a conceptualization of two forms of resourcefulness : personal ( self - help ) and social ( help - seeking ) resourcefulness . according to the theory ,
the cognitive - behavioral skills are complementary and equally important for attaining , maintaining , o... | highly resourceful individuals have been found better able to meet life 's challenges and to experience more positive health outcomes . although psychometrically sound measures of resourcefulness exist and resourcefulness training trials show that the intervention increases adaptive functioning and enhances quality of ... |
in recent years , air pollution has become a serious environmental problem especially in industrialized and populated cities ( 13 ) .
some activities such as solid waste burning , industrial processes , motor vehicles , fossil fuel combustion and other human activities can cause air pollution ( 46 ) .
air qualities... | abstractbackgrounddust pollution has become a serious environmental problem especially in recent decades .
the present study aim was the investigation of the levels of pm10 concentration in kermanshah , western iran and also measured five important heavy metals ( pb , cd , as , hg and cr ) in some samples during 2005... |
the anterior cruciate ligament ( acl ) plays an extremely important role in resistance to
anterior tibia deformation and rotational load on the knee joints1 .
the treatment goal in acl rupture is to stabilize the knee
joint and to recover the range of motion of the knee joint and the muscle strength to a
normal... | [ purpose ] the purpose of this study was to examine the effect of closed kinetic chain
exercises performed by an unstable exercise group ( ueg ) and a stable exercise group ( seg )
on the knee joint , proprioception , and functional scores of patients who underwent
anterior cruciate ligament ( acl ) reconstructi... |
a 56-year - old man who had recurrent anterior uveitis for the last 30 years was referred to our clinic due to a corneal endothelial abnormality . he had no history of immunologic and infectious disease that may cause an anterior chamber reaction or endothelial abnormality . at his first visit , slit lamp examination s... | we report a case of cmv corneal endotheliitis that was treated with intravitreal ganciclovir injection .
a 56-year - old man who has suffered from uveitis was referred to our clinic due to corneal endothelial abnormality . slit lamp examination showed a localized sectoral corneal edema and linear keratic precipitates... |
photocatalytic
reactions occur at the crystal solution interface ,
and hence specific crystal facet expression and surface defects can
play an important role . here
we investigate the structure - related
photoreduction at zinc oxide ( zno ) microparticles via integrated light
and electron microscopy in com... | |
ovarian hyperstimulation syndrome ( ohss ) typically is an iatrogenic , serious , and potentially fatal complication of supraphysiological ovarian stimulation in assisted conception cycles . in its severe form , ohss induces massive ovarian enlargement with multiple cysts , hemoconcentration , and third space accumulat... | ovarian hyperstimulation syndrome ( ohss ) with the natural ovulatory cycle is extremely rare .
we report a case of severe ohss associated with a spontaneous normal singleton pregnancy in a 23-year - old woman presenting with severe abdominal pain , vomiting , and dyspnea .
ultrasonography revealed 10 weeks viable ... |
interstitial cystitis / painful bladder syndrome ( ic / pbs ) is associated with several symptoms that include changes in bladder function and pain hypersensitivity that can develop spontaneously or be iatrogenically induced .
for example , the prolonged use of the chemotherapeutic drug cyclophosphamide leads to the ... | recent studies demonstrate that glial glutamate transporter-1 ( glt-1 ) upregulation attenuates visceral nociception .
the present work further characterized the effect of ceftriaxone- ( ctx- ) mediated glt-1 upregulation on visceral hyperalgesia .
intrathecal pretreatment with dihydrokainate , a selective glt-1 an... |
reversible cerebral vasoconstriction syndrome ( rcvs ) is a syndrome characterized by the sudden onset of severe headache , often called thunderclap headache , with multifocal segmental vasoconstriction of cerebral arteries , identifiable as a beaded appearance on imaging modalities .
reversibility of these angiograp... | reversible cerebral vasoconstriction syndrome ( rcvs ) is a syndrome characterized by severe headache with segmental vasoconstriction of the cerebral arteries that resolves within 12 weeks .
a 16-year - old girl with refractory cytopenia of childhood , who was receiving the immunosuppressant cyclosporine , developed ... |
peritoneal recurrences from colorectal cancers are common , but in many cases , surgical resection is performed without preoperative recognition of multiple lesions
. however , single peritoneal recurrence is typically recognized , and such cases are likely to undergo complete resection . nevertheless , there is no c... | abstractwe report a long - term survivor of colorectal cancer who underwent aggressive , frequent resection for peritoneal recurrences .
a 58-year - old woman was diagnosed with descending colon cancer .
resection of the descending colon along with lymph node dissection was performed in september 2006 .
the patho... |
an example of a position - specific weight matrix ( pwm ) adapted from the transfac database .
the sequences that have been shown experimentally to bind to the human transcription factor gata-1 have 14 positions , among which only positions 610 are fully conserved .
abbreviations : r , g or a ( purine ) ; n , any ;... | phylogenetic footprinting is an approach to finding functionally important sequences in the genome that relies on detecting their high degrees of conservation across different species .
a new study shows how much it improves the prediction of gene - regulatory elements in the human genome . |
danish intensive care units ( icus ) provide publicly funded intensive care to all danish inhabitants .
intensive care includes observation , diagnostics , treatment , and care for patients with potentially reversible failure of one or more organ systems .
three different levels of intensive care exist : levels 1 ,... | aim of databasethe aim of this database is to improve the quality of care in danish intensive care units ( icus ) by monitoring key domains of intensive care and to compare these with predefined standards.study populationthe danish intensive care database ( did ) was established in 2007 and includes virtually all icu a... |
localized cancer of the tongue is an ideal indication for brachytherapy [ 1 , 2 ] because emphasis is laid mainly on local control while maintaining anatomical integrity and function . though surgery is considered the standard of care , significant functional impairment may result after wide local excision of even the ... | purposeto recognize neuropathic pain as a complication of high - dose - rate ( hdr ) interstitial brachytherapy of oral tongue and to evaluate the possible causes of neuropathy.material and methodstwenty one patients who underwent interstitial brachytherapy for early cancer of oral tongue were evaluated .
the patient... |
each author has participated sufficiently in the work and takes public responsibility for appropriate portions of the content of this article . | recent food and drug administration ( fda ) approval of a roche cobas human papillomavirus ( hpv ) test application as a first line primary cervical screening tool in women 25 and older introduces a new era of complex cervical screening choices .
perhaps the most surprising findings in roche 's supporting athena tria... |
prior to this study , we obtained the approval of the animal ethics committee of kangwon national university to obtain blood samples from healthy dogs for serum
cys - c and sdma assays .
informed written consent for sample collection , including information pertinent to our investigation , were obtained from the do... | reduction in glomerular filtration rate ( gfr ) is a common complication in advanced stages of heart failure ( hf ) .
the convenient and precise assessment for gfr
would be useful for early detection of renal impairment in hf dogs .
our hypothesis of this study was the gfr would be reduced in advanced stages of h... |
laparoscopic radical nephrectomy is considered in many centers the standard of care for renal tumors in patients who are not candidates for nephron sparing surgery . in comparison to an open procedure
, the laparoscopic technique has demonstrated advantages in regard to perioperative morbidity , postoperative pain , ... | in comparison to an open procedure , the laparoscopic radical nephrectomy has demonstrated advantages in regard to perioperative morbidity , postoperative pain , time of hospitalization , and convalescence .
however , most series of laparoscopic radical nephrectomy are confined to t1 tumors .
the authors present a ... |
metabolic disorder is a highly widespread clinical entity . although obesity and insulin resistance are not synonymous with the metabolic syndrome , they are integral features in this derangement of adipocyte physiology and carbohydrate metabolism .
there are three ppar subtypes ( , , and ) and they regulate the e... | metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus .
high plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder
. thiazolidinediones ( tzds ) are potent ppa... |
prostate cancer is the most common malignancy in the us and in western europe with an estimated 186,320 newly diagnosed cases in 2008 in the us and 28,660 men who died of prostate cancer in the us ( incidence - mortality ratio of 6.5).1 the therapeutic options available predominantly depend on cancer stage as well as p... | degarelix is a gonadotropin - releasing hormone ( gnrh ) antagonist for the treatment of patients with prostate cancer in whom hormonal therapy is indicated .
two phase ii trials and one phase iii have been published as full papers in the literature . in the dose - finding phase ii studies an initial dose of 240 mg d... |
a 49-year - old policeman was admitted on may 2002 to the dermatology division of the university hospital for the treatment of a skin lesion on his leg , initially diagnosed as cutaneous zygomycosis .
the patient stated that a small pustule developed on his left leg 3 months earlier , 1 week after he fished in a lake... | pythiosis , caused by pythium insidiosum , occurs in humans and animals and is acquired from aquatic environments that harbor the emerging pathogen .
diagnosis is difficult because clinical and histopathologic features are not pathognomonic .
we report the first human case of pythiosis from brazil , diagnosed by us... |
the usefulness of constitutional diagnoses of humans using the skin of the hand is well established in medicine .
examples include the dichotomy of hippocrates , the quartering method of hall , the three constitution theory of sigauard , the cosmic dual - force fifty people principle ( ) of huang di nei jing ( ) , an... | the usefulness of constitutional diagnoses based on skin measurements has been established in oriental medicine .
however , it is very difficult to standardize traditional diagnosis methods . according to sasang constitutional medicine ,
humans can be distinguished based on properties of the skin , including its te... |
hepatitis c virus ( hcv ) is an enveloped virus containing a positive - sense , single - stranded rna genome that infects hepatocytes specifically through a noncytopathic process .
hcv is a blood - borne pathogen and results in a significant public health problem , affecting approximately 180 million people globally ... | toll - like receptor 3 ( tlr3 ) plays a key role in innate immunity by recognizing pathogenic , double - stranded rnas .
thus , activation of tlr3 is a major factor in antiviral defense and tumor eradication .
although downregulation of tlr3 gene expression has been mainly reported in patients infected with hepatit... |
acute kidney injury ( aki ) is a serious and common condition , which is thought to affect 318% of all hospitalized patients [ 14 ] .
it is associated with adverse outcomes and high mortality [ 46 ] with an estimated 40 000 plus in patient deaths annually associated with aki in the national health service ( nhs ) in ... | backgroundwe examined the prevalence of acute kidney injury ( aki ) risk factors in the emergency medical unit , generated a modified risk assessment tool and tested its ability to predict aki.methodsa total of 1196 patients admitted to medical admission units were assessed for patient - associated aki risk factors .
... |
rickettsial diseases of humans consist of a variety of clinical entities caused by microorganisms of the family rickettsiaceae .
the rickettsias are obligate intracellular parasites about the size of bacteria and are usually seen microscopically as pleomorphic coccobacilli .
murine typhus fever is an acute febrile ... | we encountered a 32-year - old korean woman who developed murine typhus in a laboratory .
she worked as a technician in a laboratory for rickettsial disease .
immunofluorescence test with rickettsial antigen ( r. typhi ) was positive at 1 : 320 on admission and 1 : 1280 after 4 weeks . a dose of 200 mg of doxycycli... |
pheochromocytoma in pregnancy is extremely rare , and only about 200 cases have been reported in literature reviews .
this disorder carries a high risk of maternal and fetal mortality if undiagnosed before delivery .
the various clinical manifestations of hypertension could resemble those of toxemia in pregnancy , ... | pheochromocytoma in pregnancy is very rare but it is associated with very high maternal and fetal mortality .
therefore , it is important to include pheochromocytoma in the differential diagnosis of hypertension associated with pregnancy .
it is difficult to make a diagnosis of pheochromocytoma in pregnancy before ... |
in 2005 , new york university created a unique partnership between the college of dentistry ( nyucd ) and the college of nursing ( nyucn ) to foster interprofessional education through collaborative curriculum designs and practice environments with the goal of creating men and women of science whose education and pract... | over the past seven years , the department of pediatric dentistry at new york university college of dentistry ( nyucd ) and the advanced practice : pediatrics and the pediatric nurse practitioner ( pnp ) program at new york university college of nursing ( nyucn ) have engaged in a program of formal educational activiti... |
spinal subdural hematoma ( ssdh ) is an uncommon cause of spinal cord compression and is usually associated with an trauma , lumbar puncture , haematological diseases , vascular malformations or anticoagulant therapy1,2,6,9 ) .
the pathogenesis of spinal subdural hematoma after cranial surgery include the downward mo... | although blood contamination of cerebrospinal fluid ( csf ) after an intracranial operation can occur , the development of a symptomatic spinal hematoma after craniotomy has been anecdotally reported and it is uncommon reported after a supratentorial meningioma removal operation .
we report a case of spinal subdural ... |
choroidal neovascular membrane ( cnvm ) is an abnormal vascular proliferation from beneath the retina and is related to many different underlying retinal conditions , especially age - related macular degeneration . over the past few years
, the introduction of anti - vascular endothelial growth factor ( anti - vegf )... | purpose : to determine the pattern of electroretinographic change after an intravitreal ranibizumab ( lucentis ) injection for the treatment of choroidal neovascular membrane ( cnvm).patients and methods : a prospective interventional case series of patients treated by intravitreal ranibizumab injection .
best correc... |
pulmonary veins ( pv ) were found to be important sources of ectopic beats for the initiation of atrial dysrrythmias.1 therefore , using diagnostic and therapeutic methods for assessing pv is recommendable .
the present case demonstrates the feasibility of advancing a conventional electrophysiology ( ep ) catheter in... | the use of diagnostic and therapeutic methods for assessing pulmonary vein due to its status as a main source of ectopic beats for the initiation of atrial dysrrythmias is strongly recommended .
we report the case of a 13-year - old girl who was admitted to our hospital with the electrocardiogram manifestation of an ... |
adjuvants fall into two major functional groups based on whether their immune activity is dependent or nor not on toll - like receptor ( tlr ) signaling [ 14 ] .
both groups can be defined as compounds that potentiate humoral and cellular adaptive immune responses to specific antigens .
the rationale for using tlr ... | aluminum salts gels ( alum ) are tlr - independent adjuvants and have been used to boost antibody responses in alum - based vaccines such as diphtheria , pertussis , and tetanus toxoid ( dpt ) triple vaccine .
however , the pro - th2 activity of alum - based vaccine formulations has not been fully appreciated .
her... |
male c57bl/6 mice ( 10 weeks old ) received streptozotocin ( stz ) ( sigma - aldrich ; 80 mg / kg / day for 2 days ) intraperitoneally .
mildly hyperglycemic mice ( blood glucose levels of 250300 mg / dl ) were given plain water or water containing gaba ( 2 or 6 mg / ml ; sigma - aldrich ) , the gabab - r specific a... | -aminobutyric acid ( gaba ) has been shown to inhibit apoptosis of rodent -cells in vitro . in this study , we show that activation of gabaa receptors ( gabaa - rs ) or gabab - rs significantly inhibits oxidative stress related -cell apoptosis and preserves pancreatic -cells in streptozotocin - rendered hyperglycemic ... |
tissues from biopsy and autopsy specimens were labeled using standard hematoxylin and eosin staining protocols or by immunohistochemical staining with an anti - cd163 antibody ( abcam ) .
exome sequencing of the index case and his parents was performed by capture on the nimblegen 2.1 exome reagent followed by 74 base... | upon detection of pathogen - associated molecular patterns , innate immune receptors initiate inflammatory responses .
these receptors include cytoplasmic nod - like receptors ( nlrs ) , whose stimulation recruits and proteolytically activates caspase-1 within the inflammasome , a multi - protein complex . caspase-1 ... |
dna double - strand breaks ( dsbs ) are a considerable threat to the integrity of the human genome and , if not properly dealt with , can cause genomic instability and cancer .
the response to dsbs entails a coordinated series of events known as the dna damage response ( ddr ) , which integrates the regulation of cel... | summarythe response to dna double - strand breaks ( dsbs ) requires alterations in chromatin structure to promote the assembly of repair complexes on broken chromosomes .
non - homologous end - joining ( nhej ) is the dominant dsb repair pathway in human cells , but our understanding of how it operates in chromatin i... |
the term coercive measures usually refers to coercive interventions occurring under hospitalization in psychiatric wards ( kalisova et al . , 2007 ) .
this includes seclusion , physical restraint , chemical restraint , mechanical restraint , and covert medication .
covert medication is commonly administered in in... | objectives : the objective of this study was to assess attitudes of indian psychiatrists and caregivers toward coercion.materials andmethods : the study was conducted at the department of psychiatry , krishna rajendra hospital , mysore , india . staff attitude to coercion scale ( sacs ) , a 15-item questionnaire , was ... |
microvascular ischemia is the most common cause of acute , isolated diplopia in individuals over age 50 ( lapresle and lasjaunias , 1986 ; richards et al . , 1992 ) . based on the few available post - mortem studies ,
the location of the lesion in these vasculopathic palsies is within the subarachnoid or intracaverno... | we describe three patients who experienced onset of a microvascular ocular motor nerve palsy in the setting of sudden emotional stress .
such emotional states are accompanied by a marked increase in sympathetic tone in some individuals .
mechanisms by which these autonomic changes might produce an ischemic cranial ... |
activation of the coagulation cascade resulting in alveolar fibrin deposition is recognized as a hallmark of acute lung injury ( ali ) and acute respiratory distress syndrome ( ards ) .
consequently , anticoagulant and fibrinolytic therapies in ali with various compounds , such as heparin , tissue factor pathway in... | activation of the coagulation cascade resulting in alveolar fibrin deposition is recognized as a hallmark of acute lung injury ( ali ) .
anticoagulant treatment with recombinant human activated protein c ( rhapc ) appears promising , because like in sepsis
there is a deficiency of protein c in ali , which is corre... |
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