article stringlengths 0 826k | abstract stringlengths 174 4.34k |
|---|---|
cd3 , pt , and c mice have been described 61213 and were bred in the specific pathogen
the following mabs were used : cd25 ( pc-61 ) conjugated to fitc , cd44 ( pgp-1)pe , cd25-pe , cd4 ( l3t4)-cychrome , cd8 ( ly-2)cychrome ( pharmingen ) , and anti - pan tcr- ( h57 - 597 ) .
biotinylated mabs were revealed with e... | we have examined the question of whether there is an additional checkpoint in t cell development that regulates t cell receptor ( tcr)- expression in cd25 + 44 thymocytes by mechanisms that are independent of the pre - tcr .
our analysis in various mutant mice indicates that all changes in cytoplasmic tcr- expression... |
hearing loss is one of the most genetically heterogeneous disorders , present in one of every 500 newborns . during the past two decades
, tremendous progress has been made in the identification of causative genes that cause hereditary nonsyndromic hearing loss ( nshl ) .
up to now , approximately 30 dominant ( dfn... | background : nonsyndromic hearing loss ( nshl ) is highly heterogeneous , in which more than 90 causative genes have currently been identified .
dfna5 is one of the deafness genes that known to cause autosomal dominant nshl . until date
, only five dfna5 mutations have been described in eight families worldwide . i... |
base excision repair ( ber ) is one of the most important dna repair pathways , which ameliorates environmentally induced dna damage , including that which arises spontaneously as a result of alkylation , oxidation , and deamination events during normal metabolic processes .
ber is also responsible for repairing smal... | the correction of exogenous and endogenous environmental insult to dna involves a series of dna repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development .
the mechanisms underlying the process of base excision repair are relatively well understood ... |
test strains and ctxb genotyping : a total of 15 toxigenic v.
cholerae o1 strains of different isolation origin and belonging to the el tor
biotype , as shown in table 1table 1.the relevant characteristics of v. cholerae strains used in this
studystrain idserogroup / biotypeantimicrobialresistance profileorigin ,... | to search natural compounds having inhibitory effect on bacterial growth is important ,
particularly in view of growing multidrug resistant ( mdr ) strains of bacterial pathogens .
like other bacterial pathogens , mdr vibrio cholerae
, the causative agent
of diarrheal disease cholera , is becoming a great conce... |
gallstone ileus is a rare mechanical bowel obstruction caused by the transition of a gallstone in the gastrointestinal tract through a biliary - enteric fistula , or following endoscopic retrograde cholangiopancreatography ( ercp ) , which occurs in 1 to 3% of all cases of mechanical ileus.1 gallstones can cause bowel ... | the diagnosis of gallstone ileus is occasionally challenging due to the variability of its presentation .
we herein present a very rare case of gallstone ileus inducing obstructive jaundice at the afferent loop of roux - en - y hepaticojejunostomy after 10 years of bile duct cancer surgery .
we describe the case of... |
with the increasing public health challenge of dementia and cognitive impairment throughout the world , the identification of a modifiable risk factor would be critical in the prevention of dementia.1 previous studies have indicated that hyperlipidemia may be a risk factor for dementia and alzheimer s disease ( ad).24 ... | introductionprevious studies have identified hyperlipidemia as a potential risk factor for dementia and alzheimer s disease .
however , studies on cholesterol measured in late - life and cognitive function have been inconsistent .
few studies have explored nonlinear relationships or considered interactions with oth... |
flublok , a trivalent recombinant hemagglutinin ( rha ) vaccine , is under development by protein sciences corporation .
the mechanism of action of flublok is the same as that of the licensed egggrown trivalent inactivated influenza vaccines ( tiv ) , thereby simplifying the regulatory pathway for product approval . ... | abstract flublok , a recombinant trivalent hemagglutinin ( ha ) vaccine produced in insect cell culture using the baculovirus expression system , provides an attractive alternative to the current eggbased trivalent inactivated influenza vaccine ( tiv ) manufacturing process .
flublok contains three times more ha th... |
rem sleep behaviour disorder ( rbd ) , first described by schenck and colleagues in 1986,1 is characterised by the loss of normal muscle atonia during rem sleep .
patients often experience violent dream - enacting behaviours leading to disturbed sleep and potential injuries to themselves and their bed partner .
whi... | backgroundconcomitant rem sleep behaviour disorder ( rbd ) is commonly observed in patients with parkinson 's disease ( pd ) .
although the brainstem structures responsible for the symptoms of rbd correspond to the premotor stages of pd , the association of rbd with motor and non - motor features in early pd remains ... |
mets , a complicated clinicopathological entity with clustering of cvd and metabolic risk factors , includes central obesity , hypertension , dyslipidemia , and glucose intolerance .
it has been pervasively recognized that individuals with mets are associated with the increased risks of type 2 diabetes and cvd [ ... | both metabolic syndrome ( mets ) and chronic kidney disease ( ckd ) are major global health issues .
current clinical markers used to reflect renal injury include albuminuria and estimated glomerular filtration rate ( egfr ) .
given the same egfr level , urine albumin might be a better risk marker to predict progre... |
benign prostatic hyperplasia ( bph ) is a major cause of lower urinary tract symptoms ( luts ) in the aging male .
it affects about 210 million males globally.1 although bph has been considered to be the most significant risk factor for luts , several studies have reported that prostate size does not correlate with t... | purposewe investigated the association of the prostatic urethral angle ( pua ) with peak urinary flow rate ( qmax ) and the severity of lower urinary tract symptoms ( luts ) on the aging male .
we also evaluated the effect of the pua on the treatment efficacy of tamsulosin on men with luts.materials and methodsthe re... |
with the advent of laparoscopy , repair of ventral hernias has undergone a revolution . with continuous improvement in technology and instrumentation ,
on the other hand , laparoscopic repair of large ventral hernias can be technically challenging .
various factors influence the complexity of the procedure , an imp... | background : intraperitoneal onlay mesh repair is an established modality to treat large ventral hernias . various techniques of laying the mesh are utilized .
we present the double rolling and center hitch technique to lay a large intraperitoneal onlay mesh.objective:the aim of the study is to devise and adopt a met... |
it is also called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components .
there are very few case reports of chondroid syringoma diagnosed on fine needle aspiration cytology ( fnac ) .
this case is reported because of unusual site of occurrence , large size , and showing v... | chondroid syringoma is a rare benign skin adnexal tumor of eccrine / apocrine origin affecting commonly the head and neck region .
it is also called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components .
there are very few case reports of chondroid syringoma diagnosed on ... |
perioperative morbidity is particularly frequent with colectomy and results in additional financial burden for the patients as well as the health care systems .
colectomy is also associated with significant physiological stress as a result of the surgical procedure itself , which may impact the risk of complications ... | aim . surgical trauma and associated complications
are frequently related to physiological stress during colectomy .
this study evaluated the response of adiponectin , resistin , and circulating soluble receptor for advanced glycation end products ( srage ) in colectomy patients with or without an enhanced recove... |
consensus definitions of cachexia ( international classification of disease , 9th revision , clinical modification ( icd-9-cm ) code 799.4 ) and debility ( icd-9-cm code 799.3 ) have been slow to emerge . in fact , these conditions are classified in the icd-9-cm as ill - defined conditions .
it is commonly a sequel... | objective : to characterize the frequency , cost , and hospital - reported outcomes of cachexia and debility in children and adolescents with complex chronic conditions ( cccs).methods : we identified children and adolescents ( aged 20 years ) with cccs , cachexia , and debility in the kids inpatient database [ healthc... |
left ventricular ( lv ) heart failure ( hf ) is a prevalent cardiac syndrome , characterized by altered lv size and shape , elevated filling pressure , increased biomarkers , specific risk factors , plus a wide variety of symptoms and signs.1 in hf often a distinction is made between patients on the basis of their ejec... | in left ventricular heart failure , often a distinction is made between patients with a reduced and a preserved ejection fraction ( ef ) .
as ef is a composite metric of both the end - diastolic volume ( edv ) and the end - systolic ventricular volume ( esv ) , the lucidity of the ef is sometimes questioned . as an a... |
bisphosphonates are analogues of inorganic pyrophosphates , which are commonly used in the treatment of osteoporosis , metastatic osteolytic bone disease and primary resorptive malignancies of bone like multiple myeloma .
the indications of bisphosphonate therapy in patients with metastatic breast cancer are to reduc... | background : bisphosphonate therapy is widely used for the treatment of bone metastasis in breast cancer patients.aim:the aim of this study is to estimate the overall prevalence of bisphosphonate induced osteonecrosis of jaw ( bonj ) in breast cancer patients with bone metastasis.materials and methods : a literature re... |
study area - central - west brazil covers an area of 1,606,371
km and consists of the following four federal units : mt , ms , go and df .
the region is divided into 467 municipalities , most of which are in go [ brazilian
institute of geography and statistics ( ibge.gov.br/cidades ) ] , which has a population of... | this study updates the geographic distributions of phlebotomine species in
central - west brazil and analyses the climatic factors associated with their
occurrence .
the data were obtained from the entomology services of the state
departments of health in central - west brazil , scientific collections and a lit... |
cardiovascular disease ( cvd ) is one of the main causes of death across most countries . providing prompt emergency care within the golden hour
therefore , real - time monitoring of cardiac health in daily life is useful for patients with cardiovascular disease .
currently , outpatient service is still the major ... | real - time monitoring of cardiac health is helpful for patients with cardiovascular disease .
many telemedicine systems based on ubiquitous computing and communication techniques have been proposed for monitoring the user 's electrocardiogram ( ecg ) anywhere and anytime .
usually , wet electrodes are used in thes... |
there are several well - known and established medicinal plant heritages worldwide including the kampo , tcm , tim and ayurveda .
there has been increased global interest in traditional medicine and there are efforts underway to monitor and regulate herbal drugs and traditional medicine .
china has been successful ... | complementary medicine is a formal method of health care in most countries of the ancient world .
it is expected to become more widely integrated into the modern medical system , including the medical curriculum . despite the perception of modern medicine as more efficacious , traditional medicine continues to be pra... |
coccidiosis , a major poultry enteric disease caused by protozoan parasites of the genus eimeria , results in significant economic losses to the poultry industry .
currently , although chemoprophylaxis is the predominant method used to control coccidiosis , alternate options are needed due to the emergence of drug re... | we previously reported that the chimeric dna vaccine pcdna-3 - 1e - linker - mchil-15 , fused through linking eimeria acervulina 3 - 1e encoding gene and mature chicken il-15 ( mchil-15 ) gene with four flexible amino acid spgs , could significantly offer protection against homologous challenge . in the present study ,... |
this figure is expected to grow by 20% over the next decade as the aging population increases and lives longer .
neurodegenerative diseases are the fourth leading cause of death in the developed world after heart diseases , cancer , and stroke
. there are millions of sufferers worldwide , and the start of the disea... | neurodegenerative diseases , such as alzheimer 's disease and parkinson 's disease represent a huge unmet medical need .
the prevalence of both diseases is increasing , but the efficacy of treatment is still very limited due to various factors including the blood brain barrier ( bbb ) .
drug delivery to the brain r... |
bread is universally accepted as a very convenient form of food that is important to all populations .
its origin dates back to the neolithic era and is still one of the most consumed and acceptable staple food products in all parts of the world .
it is a good source of nutrients , such as macronutrients ( carbohyd... | dehydrated uncooked potato ( irish and sweet ) flour was blended by weight with commercial wheat flour at 0 to 10% levels of substitution to make bread . comparative study of the microbial and nutritional qualities of the bread was undertaken .
the total aerobic bacterial counts ranged from 3.0 105 cfu / g to 1.09 ... |
a safe , effective , and visually controlled method for entering the upper urinary tract was possible due to the development of rigid , semi - rigid , and flexible ureterorenoscopes of even smaller diameters . improvement with respect to procedural techniques and more effective devices for fragmenting calculi increased... | introductionthe rapid development and invention of ever more technologically advanced ureterorenoscopes as well as other instruments used in fragmenting ureteral stones have made the traditional surgical treatment of ureterolithiasis very rare.material and methodswe investigated 727 patients treated for ureterolithiasi... |
artificial and natural teeth , metallic dental implants , as well as restorative materials within the mouth interact continually with physiological fluids .
they function in one of the most inhospitable environments in the human body . during 24 hours
, restorations and teeth are exposed to a variety of eatables , ... | the oral cavity provides an ideal and unique environment for study of biological processes involving metallic dental aids .
dental materials within the mouth interact continually with physiological fluids .
oral tissues are exposed to a veritable bombardment of both chemical and physical stimuli as well as the meta... |
mllerian inhibiting substance ( mis ) inhibits mammary tumor growth in vitro and in mouse models of breast cancer .
control study to determine whether mis serum concentrations from blood samples that were collected before diagnosis are associated with breast cancer risk .
the association did not vary with age at bl... | backgroundmllerian inhibiting substance ( mis ) is a member of the transforming growth factor family of growth and differentiation factors that inhibits elongation and branching of mammary ducts and has been shown to inhibit mammary tumor growth in vitro and in animal models .
the objective of this study was to dete... |
percutaneous coronary intervention ( pci ) has been widely used to treat obstructive coronary artery disease , including unstable angina , recurrent angina after coronary artery bypass grafting ( cabg ) , and acute myocardial infarction ( mi ) , contributing to the reduction of clinical symptoms and mortality rate.13 a... | backgroundpercutaneous coronary intervention ( pci ) has been widely used to treat acute coronary syndrome but is only recommended as an additional treatment to medical therapy and risk modification in patients with refractory or progressing angina .
the number of pci in this patient population is still increasing . ... |
aortic stenosis ( as ) is the most frequently acquired native valvular disease afflicting the elderly population in western countries .
the prevalence of degenerative as among the elderly in korea is also increasing as the korean population is growing older .
symptomatic severe as is a lethal disease with a 2-year ... | surgical replacement of the aortic valve is the standard therapy for severe aortic valve stenosis .
however , it is generally associated with increased mortality and morbidities in older individuals .
transcatheter aortic valve implantation ( tavi ) is a less invasive procedure and has shown similar clinical outcom... |
carbamazepine ( cbz ) , a commonly prescribed medication in psychiatry and neurology , produces side effects with an incidence ranging from 33%50% .
cbz - induced hyponatremia is a well - described side effect , and numerous studies have shown that age , hyponatremia dosage / level , and polypharmacy are predisposing... | a 31-year - old man had been treated with carbamazepine ( cbz ) for 6 years and warfarin with bucolome for 2 years before developing hyponatremia 7 days after an injection of interferon - alpha 2b and starting oral ribavirin for chronic hepatitis c virus infection . despite the hyponatremia ,
urinary osmolality excee... |
epidemiological studies have brought into being that intake of antioxidants such as vitamin c reduces the risk of coronary heart diseases and cancer .
it is possible to reduce the risk of chronic diseases and to prevent disease progression by either enhancing the body 's natural antioxidant defense or by supplementin... | context .
many diseases are associated with oxidative stress caused by free radicals . objective .
the present study evaluated the in vitro antioxidant and antibacterial activities of various extracts of aerial parts of periploca aphylla and ricinus communis .
materials and methods . in vitro antioxidant activiti... |
prematurity continues to be the major cause of neonatal morbidity and mortality across the world accounting for an enormous 70% of neonatal deaths in nonanomalous babies . despite decades of research ,
we are no closer to finding answers in terms of prediction and hence prevention of preterm labour .
this is in sha... | background and objectives .
this is a prospective nested cohort study conducted over a period of 3 years .
2644 women were recruited , out of which final analysis was done for 1884 women . methods .
cervicovaginal and blood samples were collected for all recruited women . out of these ,
137 women who delivered ... |
tuberculosis ( tb ) and human immunodeficiency virus type 1 ( hiv-1 ) infection are major health problems in women , particularly during their reproductive years ( 1549 ) . in a recent analysis
, we observed that hiv-1-infected women with latent tb infection ( ltbi ) as detected by a positive interferon - gamma ( ifn... | background . we determined the consistency of positive interferon - gamma ( ifn- ) release assays ( igras ) to detect latent tb infection ( ltbi ) over one - year postpartum in hiv-1-infected women .
methods . women with positive igras during pregnancy had four 3-monthly postpartum igras .
postpartum change in magn... |
body composition is not only influenced by genetic and environmental factors , but also by physical activity and nutritional factors .
mechanical stress related to physical activity is sensed by osteocytes and stimulates accrual of bone mineral content .
both muscle and fat tissues contribute to this mechanism , by... | introduction : in view of the relationship between physical activity and nutrition on body composition , we assessed lean and fat mass and bmc ( total and regional ) in professional indian sportswomen and compared it with apparently healthy age- and sex - matched females.materials and methods : this cross - sectional s... |
glomus tumors are benign hamartomas arising from the glomus body , mostly occurring in the subungual region of the digits .
a triad of excruciating pain , localized tenderness and cold sensitivity is the key to diagnosing these tumors .
two surgical approaches are described in the literature for excision of subungu... | background : glomus tumors are benign hamartomas arising from the glomus body , mostly occurring in the subungual region of the digits . a triad of excruciating pain , localized tenderness and cold sensitivity is the key to diagnosing these tumors .
two surgical approaches are described in the literature for excision... |
temperatures are rising as greenhouse gas concentrations increase . it has been suggested that the distribution of summer temperatures in the northern hemisphere shifted to the right ( i.e. , increased ) in 2001 - 2011 , as compared with the normal distribution found in 1951 - 1980 ( 1 ) .
temperature impacts human h... | studies conducted to evaluate temporal trends of heat - related mortality have not considered the effects of heat waves ; although it is known they can affect mortality and act as a modifying factor .
after adjusting for long - term trends and seasonality , the effects of temperature on non - accidental deaths in seo... |
mechanical ventilation is used for some infants in neonatal intensive care units ( nicu ) due to many physiological and clinical causes .
since these patients have endotracheal tubes , cleaning and keeping the airways open through suctioning should be done to increase oxygenation .
this study aimed to evaluate effe... | aims : mechanical ventilation is used for some infants in neonatal intensive care units ( nicu ) due to many physiological and clinical causes .
since these patients have endotracheal tubes , cleaning and keeping the airways open through suctioning should be done to increase oxygenation .
this study aimed to evalua... |
optical rotations were
recorded on a jasco p-2000 polarimeter , and uv spectra were measured
on a shimadzu uv-1201 spectrophotometer .
ecd analysis was performed
on a jasco j-810 spectropolarimeter with a 0.1 cm cell in meoh at
room temperature under the following conditions : speed 50 nm / min ,
time const... | investigation of a dcm extract of
the bark of pleiogynium
timoriense from the former merck collection of natural product
extracts for antiproliferative activity indicated that it was active
with an ic50 value of 1.3 g / ml against the a2780
ovarian cancer cell line .
bioassay - directed fractionation of thi... |
multiple sclerosis ( ms ) is an autoimmune inflammatory disease of the cns , characterized by focal demyelination , loss of axons , and gliosis that result in neurological symptoms .
while our understanding of ms immunopathology continues to improve , the underlying etiology of the disorder remains unclear .
the ov... | background . mitoxantrone ( mtx ) and rituximab ( rtx ) are successfully used for treatment of multiple sclerosis ( ms ) and can be combined to increase efficacy . objective .
we used mtx , rtx , and methylprednisolone in a single combined regiment and observed patients prospectively .
methods .
we present result... |
the movement toward primary care as a model of health care service delivery was introduced 30 years ago and has been moving in that direction since then .
public health nurses ( phns ) due to their public health orientation and guiding philosophy are acutely sensitive to any proposed changes in health policy underpin... | health of populations is determined by a multitude of contextual factors . primary health care reform endeavors to meet the broad health needs of populations and
remains on international health agendas .
public health nurses are key professionals in the delivery of primary health care , and it is important for them... |
we treat pathogen dissemination as a stochastic ( chance - based ) sequence of discrete encounters between incident patients ( p ) who are either infectious or noninfectious , a caregiver ( c ) , and the environment ( fomites , such as surfaces or waiting room magazines , [ e ] ) , each of which can be contaminated or ... | we developed a model of pathogen dissemination in the outpatient clinic that incorporates key kinetic aspects of the transmission process , as well as uncertainty regarding whether or not each incident patient is contagious . assigning appointments late in the day to patients suspected of being infectious should decrea... |
data were derived from the depression and myocardial infarction study ( depremi ) ( 18 ) and the myocardial infarction and depression - intervention trial ( mind - it ) ( 19 ) . in these multicenter studies , 528 and 2,176 mi patients , respectively , were screened for depression .
patients were recruited from 14 hos... | objectivediabetes and depression are both linked to an increased mortality risk after myocardial infarction ( mi ) . population - based studies suggest that having both diabetes and depression results in an increased mortality risk , beyond that of having diabetes or depression alone .
the purpose of this study was t... |
stroke is the third most common cause of death and the most common cause of disability in developed countries . due to the aging population ,
it has been reported by the world health organization ( who ) that about 15 million people suffer from ischemic stroke ( is ) every year , of which 5 million were dead and 5 mi... | background : numerous studies have evaluated the association between the angiotensinogen ( agt ) t174 m polymorphism and ischemic stroke(is ) risk . however , the specific association is still controversial.materials and methods : in order to explore this association more deeply , we performed a meta - analysis .
all... |
magnetic resonance spectroscopy ( mrs ) , a powerful noninvasive technique , is being increasingly applied to delineate biochemical changes of the liver [ 15 ] .
it can identify metabolite profiles in vivo , providing quantitative or semiquantitative measures of some metabolites .
it is a key tool especially for le... | backgroundto quantify the metabolite changes in hepatic tumors by single - voxel 1h magnetic resonance spectroscopy ( mrs ) at 3.0 t and explore the application value of 1hmrs in the diagnosis of hepatic benign and malignant lesions.material/methodsa total of 45 patients ( 55 lesions ) diagnosed with hepatic lesions by... |
participants from several studies conducted in east asians were used for the analyses presented here . these included 2,282 chinese living in singapore from the singapore prospective study program ( sp2 ) ( 13 ) , 3,290 japanese from the nomura study ( 14 ) and the ehime university hospital antiaging center ( aac ) stu... | variants in the cdh13 gene have been identified as determinants of blood levels of adiponectin , an insulin - sensitizing adipokine .
however , their association with other metabolic risk factors remains unclear .
we examined variants at cdh13 in relation to total and high - molecular - weight ( hmw ) adiponectin u... |
clearance of apoptotic cells ( ac ) by macrophages , also called efferocytosis , plays a central role in tissue homeostasis , and the impaired clearance of altered cells has been associated with the development of autoimmune and chronic inflammatory diseases .
m1 or classically activated macrophages are induced by th... | phagocytosis of apoptotic cells ( efferocytosis ) induces macrophage differentiation towards a regulatory phenotype ( il-10high / il-12p40low ) .
cd36 is involved in the recognition of apoptotic cells ( ac ) , and we have shown that the platelet - activating factor receptor ( pafr ) is also involved . here , we inves... |
diabetes is a major public health problem associated with a huge economic burden in developing countries .
a population based study reported that the total cost ( direct and indirect ) of diabetes care in india was 31.9 billion usd .
a similar study evaluated the cost of treating long term diabetic complications in... | patients with complications of diabetes such as retinopathy , nephropathy , and cardiovascular complications have increased hospital stay with greater economic burden .
prevention of complications should be started before the onset of type 1 diabetes mellitus ( t1 dm ) by working on risk factors and thereafter by int... |
coronary heart disease is the leading cause of death worldwide , responsible for over 7 million deaths annually .
indian asians ( people originating from india , pakistan , bangladesh and sri lanka ) comprise one quarter of the globe 's population and are at high risk of developing chd .
recent estimates from the g... | the indian asian population accounts for a fifth of all global deaths from coronary heart disease ( chd ) .
chd deaths on the indian subcontinent have doubled since 1990 , and are predicted to rise a further 50% by 2030 .
reasons underlying the increased chd mortality among indian asians remain unknown .
although... |
malaria parasites are capable of modulating the proportion of blood stage asexual parasites that develop into nonreplicating transmission stages ( gametocytes ) .
unfavorable conditions for asexual replication , and thus future transmission opportunities , stimulate an increase in short - term gametocytogenesis [ 13 ... | the generation of sexually committed parasites ( gametocytogenesis ) is poorly understood in malaria . if the mechanisms regulating this process were elucidated , new opportunities for blocking malaria transmission could be revealed .
here we compare several methods described previously for the in vitro production of... |
a 57-year - old man was transferred to emergency department of ajou university hospital for treatment of stanford type a aortic dissection .
the patient had chronic kidney disease ( serum creatinine , 1.8 mg / dl ) and mild cognitive impairment ( mini - mental state examination score , 16 ) due to previous tuberculou... | the dehiscence of saphenous vein grafts ( svgs ) is a rare , often fatal , complication of coronary artery bypass grafting ( cabg ) .
we present the case of a 57-year - old man who underwent hemiarch graft interposition and cabg for a stanford type a aortic dissection .
five months after discharge , the patient dev... |
pharmacopuncture , a new therapy in traditional medicine , has attracted significant attention since its introduction to the western world .
this short review article employs a database analysis to examine the profile of publication activity related to pharmacopuncture .
about 300 papers related to the topic " phar... | objective : pharmacopuncture , a new therapy in traditional medicine , has attracted significant attention since its introduction to the western world .
this short review article employs a database analysis to examine the profile of publication activity related to pharmacopuncture.methods:three databases were searche... |
all study children were participants in the ongoing population - based dipp study , which is a survey of the natural course of preclinical type 1 diabetes in genetically susceptible individuals born in the cities of turku , oulu , and tampere in finland ( 13 ) .
after parental consent , the newborns carrying hla - dq... | objectiveto compare the ages and sequence in which antibodies associated with type 1 diabetes and celiac disease appear and overt diseases develop in children with an hla - conferred susceptibility to both diseases.research design and methodswe observed 2,052 children carrying genetic risks for both type 1 diabetes and... |
to survive and thrive in diverse and perpetually changing environments , bacteria employ numerous strategies to sense and adapt to their surroundings .
one such system is the second messenger 3,5-cyclic diguanylic acid ( c - di - gmp ) signaling network .
similar to other cyclic nucleotide second messenger syste... | the second messenger cyclic di - gmp ( c - di - gmp ) regulates numerous phenotypes in response to environmental stimuli to enable bacteria to transition between different lifestyles .
here we discuss our recent findings that the human pathogen vibrio cholerae recognizes 2 host - specific signals , bile and bicarbona... |
guillain - barr syndrome ( gbs ) is an acute peripheral neuropathy classified into at least four subgroups by electrodiagnostic criteria , pathology , and anti - ganglioside antibody profiles .
gbs has been reported in patients with primary hiv infection , although this is not commonly observed . in hiv - infected pa... | guillain - barr syndrome ( gbs ) has been reported in hiv - infected patients in association with the immune reconstitution syndrome whose symptoms can be mimicked by highly active antiretroviral therapy ( haart)-mediated mitochondrial toxicity .
we report a case of a 17-year - old , hiv - infected patient on haart w... |
leishmaniasis is endemic in 98 regions and countries in the world with the annual incidence and prevalence of about 2 and 12 million people , respectively ( 1 ) . as a major global health ,
it includes a group of diseases caused by protozoan parasites of the genus leishmania transmitted to mammals through female phle... | leishmaniasis is an endemic parasitic disease in iran . this paper reports the case of a 5-yr - old boy who presented with multiple isolated cervical lymphadenopathy for several months with no history of fever and no signs or symptoms . in an excisional lymph node biopsy
, leishmania parasites were histologically det... |
tumor angiogenesis is a crucial contributor to tumor development and progression because tumor blood vessels supply oxygen and nutrients to the tumor tissue and facilitate cancer cell invasion and metastasis .
tumor vessels are usually disorganized and excessively branched [ 24 ] , and formation of the tumor va... | much has been learned about the mechanisms underlying tumor angiogenesis , and therapies that target vascular endothelial growth factor ( vegf ) to limit tumor angiogenesis and subsequent disease progression have recently been approved .
however , the transcriptional mechanisms that regulate pathological angiogenesis... |
toxoplasmosis , a zoonosis caused by a protozoan , toxoplasma gondii , is probably the most widespread human parasitosis .
asexual phase occur in warm blooded animals , and human acquire the parasite in this phase ( 1 ) .
most pregnant women with acute acquired infection do not experience obvious symptoms or signs ... | aimwe investigated whether the level of il8 was different in patients with chronic and acute toxoplasma gondii infection during the pregnancy compared with control group.backgroundit is well established that t.gondii infection induces a strong cell - mediated immune response.patients and methodselisa was used to determ... |
the cause seems to be thyroxine , cortisol , and growth hormone ( gh ) deficiency ; however , the precise pathophysiology is poorly understood and only a few cases in adults have been described in the literature .
adults with this disorder develop irreversible chronic liver failure , which is why hormonal replacement... | we report a rare case of an adult with advanced liver failure in the setting of an untreated congenital panhypopituitarism . a 32-years - old man presented with a newly onset seizure episode secondary to hypoglycemia . in the initial exploration
, we found eunuchoid habitus , absence of secondary sexual characteristi... |
a eukaryotic cell 's progression through g1 , s , g2 and m phases of the cell replication division cycle is orchestrated by large - amplitude fluctuations in cyclin - dependent protein kinase ( cdk ) activities that are generated by a series of coupled positive and negative feedback loops ( novak et al , 2007 ; holt et... | the eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of executor ' proteins ( eps ) involved in cell growth and division .
cyclin - dependent protein kinases ( cdks ) play central roles in regulating the production , activation , inactivation and destruction of these eps . f... |
thiophenol ( 1 mmol ) and zni2 ( 20 mol % ) were added to a 15 ml tube equipped with a stirring bar .
then , the tube was flashed with argon and vacuum three times , and 1 ml of toluene and 2 equiv of tbhp ( 70 % in water ) were injected through a syringe .
after that , the tube was closed and heated to 80 ... | abstractin this communication , we developed a new procedure for the synthesis of hydroxysulfides from thiophenols or diaryl disulfides with tbhp as the oxidant . in the presence of zinc iodide or potassium iodide , with tbhp as the oxidant and prereactant ,
thiophenols and diaryl disulfides reacted with the methyl g... |
color vision deficiency ( cvd ) , also referred to as color blindness , is defined as the inability to distinguish certain shades of color or in more severe cases , see colors at all . around 5%8% of men and 0.8% of women have certain kinds of cvd . unlike people with normal color vision , people with cvd report diff... | color vision deficiency ( cvd ) is an extremely frequent vision impairment that compromises the ability to recognize colors . in order to improve color vision in a subject with cvd , we designed and developed a wearable improved vision system based on an augmented reality device .
the system was validated in a clinic... |
intrauterine contraceptive devices ( iucd ) are widely used reversible contraceptive method and are cost - effective and have low complication rates .
uterine perforation during the insertion is an uncommon complication of iucd and its incidence range from 0 to 1.6/1000 insertion .
once the iucd has penetrated the ... | intrauterine contraceptive devices ( iucd ) have been associated with the multitude of complications .
we present a rare case report of a 30-year - old female in whom the iucd ( cu - t ) migrated into the urinary bladder leading to calculus formation .
the migrated iucd encrusted with stones was successfully retrie... |
cholecystokinin 2 ( cck-2 ) receptor overexpression has been demonstrated in a high percentage of various tumours such as medullary thyroid carcinomas ( > 90% ) and small - cell lung cancer ( 89% ) . due to this high expression , cck-2 receptors might be suitable targets for radionuclide imaging and/or radionuclide the... | purposecholecystokinin 2 ( cck-2 ) receptor overexpression has been demonstrated in various tumours such as medullary thyroid carcinomas and small - cell lung cancers . due to this high expression , cck-2 receptors might be suitable targets for radionuclide imaging and/or radionuclide therapy .
several cck-2 receptor... |
polyglutamine ( polyq ) repeats are implicated in several neurodegenerative diseases , including huntington s disease and several spinocerebellar ataxia s .
it is commonly thought that a toxic gain - of - function mechanism is triggered by the presence of a polyq tract , involving a conformational change within the p... | the polyglutamine diseases are caused in part by a gain - of - function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposition of -sheet rich aggregates .
recent evidence suggests that the misfolding mechanism is context - dependent , and that properties of... |
advances in perioperative care and decreased operative morbidity have resulted in the migration of inpatient procedures to the outpatient setting .
the management of hypospadias exemplifies this trend ; from 1997 to 2000 , inpatient encounters for hypospadias decreased by seventy - five percent .
information regard... | purposehypospadias is the most common congenital penile anomaly .
information about current utilization patterns of inpatient hypospadias repair as well as complication rates remain poorly evaluated.materials and methodsthe nationwide inpatient sample was used to identify all patients undergoing inpatient hypospadias... |
to generate microvilli , epithelial cells must overcome physical forces that oppose membrane deformation including membrane bending stiffness ( , pnnm ) , surface tension ( tm , pn / m ) , and membrane cytoskeleton adhesion energy ( , pnnm / nm ; sheetz , 2001 ; nambiar et al . , 2010 ) .
to this end , cells harne... | epithelial cells from diverse tissues , including the enterocytes that line the intestinal tract , remodel their apical surface during differentiation to form a brush border : an array of actin - supported membrane protrusions known as microvilli that increases the functional capacity of the tissue .
although our und... |
the success of adhesive bonding of a ceramic restoration depends on a number of factors such as the ceramic system , luting agent , curing light characteristics , and surface treatments . among those ,
adequate polymerization of the resin - based luting cement is one of the critical factors for the stability and clin... | purposethe aim of this in vitro study was to examine the curing efficiency of various resin - based materials polymerized through ceramic restorations with 3 different thicknesses . curing efficiency
was evaluated by determining the surface microhardness ( vhn ) of the resin specimens.materials and methodsfour kinds ... |
female brca1 and brca2 mutation carriers have a significantly higher lifetime risk of breast and ovarian cancer .
brca1 and brca2 proteins play major roles in dna double - strand - break repair through homologous recombination , so their deficiencies can impair the capacity of cancer cells to repair dna cross - links... | germline mutations in the brca1 or brca2 genes are associated with an increased risk of breast and ovarian cancer development .
both genes are involved in dna repair , and tumors harboring genetic defects in them are thought to be more sensitive to dna - damaging agents used in chemotherapy . however , as only a mino... |
whereas the vast majority of abdominal aortic aneurysms ( aaa ) rupture into the retroperitoneum , in up to 3%-5.5% of the patients bleeding in the duodenum , inferior vena cava ( ivc ) , iliac , or left renal vein may occur .
most usually observed in elderly people , spontaneous aortocaval fistula ( acf ) represents... | aortocaval fistula represents a rare , life - threatening complication of abdominal aortic aneurysm that needs emergency surgical treatment .
the presentation couples that of a rupturing aneurysm with other more characteristic features resulting from the massive arteriovenous shunt .
early recognition and emergency... |
a good complete denture should provide esthetics , restore function , and be biocompatible with supporting and surrounding oral tissues .
a successful denture should have dimensional stability in order to enhance chewing efficiency , increase patients ' comfort , and prevent injury to the oral tissue . during process... | background .
type of materials used in fabrication of denture base has an effect on dimension during denture base material processing and other factors related to clinical use .
objective .
the study aims were to assess the dimensional stability including thermal changes of three different denture base materials ... |
plant triterpenoids , which include sterols , steroids , and brassinosteroids , constitute a large and structurally diverse group of natural products , with over 100 different carbon skeletons [ 1 , 2 ] .
sterols and nonsterol triterpenoids are synthesized via the cytoplasmic acetate / mevalonate pathway and share co... | plant triterpenoids represent a large and structurally diverse class of natural products .
a growing interest has been focused on triterpenoids over the past decade due to their beneficial effects on human health .
we show here that these bioactive compounds are major constituents of several aerial parts ( floral b... |
a 24-year - old man was admitted to the armed forces capital hospital to investigate a left testicular mass , which had been incidentally detected in a plain radiograph taken for lower back pain ( fig .
a left orchiectomy was performed , whereupon the testis was found to contain a 1.1-cm , well - demarcated , stony h... | a 24-year - old man was admitted due to an incidentally detected mass in his left testis , which showed radiopaque calcification on plain x - ray film .
left orchiectomy was performed , and the resected testis contained a well - demarcated , hard mass measuring 1.1 cm .
histological analysis revealed that the tumor... |
extracorporeal membrane oxygenation ( ecmo ) is used to preserve life in acute ( de novo or decompensation of chronic ) cardiac and/or respiratory failure , when optimal conventional therapy fails . offering temporary support ,
veno - arterial ecmo is used in cardiac or cardiorespiratory failure , while veno - venous... | extracorporeal membrane oxygenation ( ecmo ) is increasingly applied in adults with acute refractory respiratory failure that is deemed reversible .
bleeding is the most frequent complication during ecmo support .
severe pre - existing bleeding has been considered a contraindication to ecmo application . neverthele... |
the fragile x syndrome ( fxs ) is the most frequent form of inherited intellectual disability ( jacquemont et al .
patients with fxs have physical features , such as large ears , an elongated face , and a high arched palate , which have been reported in 60% of prepubertal fxs boys .
other symptoms include connectiv... | the fragile x syndrome ( fxs ) is a leading cause of intellectual disability ( i d ) and autism .
the disease is caused by mutations or loss of the fragile x mental retardation protein ( fmrp ) , an rna - binding protein playing multiple functions in rna metabolism .
the expression of a large set of neuronal mrnas ... |
al - zhoughbi et al1 defined tumor macroenvironment as the pathological interaction between the tumor cells , as well as the tumor microenvironment , with other organs and systems of the body , which emphasizes the influence of tumors on the whole body .
a number of studies have been done to understand the role of ... | metabolic abnormalities are common in cancers , and targeting metabolism is emerging as a novel therapeutic approach to cancer management .
pituitary adenoma ( pa ) is a type of benign tumor .
impairment of tumor cells metabolism in pa seems not to be as apparent as that of other malignant tumor cells ; however , a... |
a 27-year - old female patient who had developed progressive dyspnea and chest discomfort after spontaneous delivery 2 months ago was diagnosed with severe mitral stenosis ( ms ) accompanied by mitral regurgitation ( mr ) .
she was scheduled for mitral valvuloplasty under minimally invasive thoracic incision using au... | sudden sensorineural hearing loss has been reported to occur following anesthesia and various non - otologic surgeries , mostly after procedures involving cardiopulmonary bypass .
unilateral sensorineural hearing loss resulting from microembolism is an infrequent complication of cardiopulmonary bypass surgery that ha... |
first described in 1957 , moyamoya disease is an extremely rare cerebrovascular condition that predisposes affected patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches .
further , reduced blood flow in the major vessels of the circulati... | abstractmoyamoya disease is an extremely rare cerebrovascular condition that predisposes affected patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches . to our knowledge
, this is the first report of a lethal complication due to moyamoya... |
maxillary molar distalization is a frequently preferred nonextraction treatment option for patients with class ii malocclusion . in recent years
, several intraoral appliances have been designed , which are expected to be more patient - friendly and maximize patient cooperation.123 the application site based on the d... | objectiveto compare the transverse dental changes induced by the palatally applied frog appliance and buccally applied karad 's integrated distalizing system ( kids).methodswe evaluated the pre- and post distalization orthodontic models of 39 patients , including 19 treated using the frog appliance , which is palatally... |
non - alcoholic fatty liver disease ( nafld ) is considered as the most common cause of liver disease in the pediatric age group .
overweight is known as the main predictor of nafld among children . in view of the rapidly increasing trend of childhood obesity ; it is becoming a health problem for children and adolesc... | objectivethis study aimed to develop and test the validity of a risk score to be used as a simple tool to identify those children at high risk of sonographic non - alcoholic fatty liver disease ( nafld).methodsthis cross - sectional study was conducted among 962 participants aged 618 years in isfahan , iran .
they co... |
although conventional hearing aids can provide ample benefit for patients with mild to severe hearing loss , patients experience several problems including acoustic feedback , occlusion effect , discomfort , infection , and unsatisfactory cosmesis .
the vibrant soundbridge ( vsb , med - el , innsbruck , austria ) is ... | in patients with mild to severe hearing loss , conventional hearing aids offer limited benefits and
several problems with feedback and cosmesis .
middle ear implants are a feasible option
for patients with moderate to severe hearing loss who are unable to achieve adequate benefit
from or can not tolerate hearin... |
autoimmune pancreatitis ( aip ) is a type of chronic pancreatitis characterized by an autoimmune inflammatory process in which prominent lymphocyte infiltration with associated fibrosis of the pancreas causes organ dysfunction .
although there has been an increase in the number of reports of aip in recent years , the... | autoimmune pancreatitis ( aip ) can be difficult to distinguish from pancreatic cancer .
we report a case of histopathologically proven aip mimicking neuroendocrine tumor ( net ) or pancreatic cancer in a 53-year - old man .
he was referred to our hospital for further evaluation of a pancreatic mass detected on ult... |
nonhealing wound is a hallmark of diabetes and the leading cause of nontraumatic lower extremity amputation .
the lifetime risk of a person with diabetes developing a chronic foot ulcer could be as high as 25% .
therefore , developing effective and economical therapies for correcting impaired healing of diabetic wo... | impaired wound healing in diabetic patients is a serious complication that often leads to amputation or even death with limited effective treatments .
tuo - li - xiao - du - san ( tlxds ) , a traditional chinese medicine formula for refractory wounds , has been prescribed for nearly 400 years in china and shows good ... |
scanning probe microscopy studies of single
adatoms on surfaces have revealed novel physical phenomena . in addition , single - metal adatoms on oxide supports have shown remarkable
performance in catalytic reactions .
approaches to produce single - metal adatom
arrays include mass - selected soft - landing , w... | nickel
vapor - deposited on the srtio3(110 ) surface was studied
using scanning tunneling microscopy , photoemission spectroscopy ( pes ) ,
and density functional theory calculations .
this surface forms a ( 4
1 ) reconstruction , composed of a 2-d titania structure with
periodic six- and ten - membered na... |
l'amlioration de l'accs l'arthroplastie totale de la hanche et du genou est devenue une priorit .
sans mcanismes solides pour en assurer la pertinence , ces procdures pourraient tre surutilises , ce qui engendrerait des cots importants .
dans ce contexte , les dcideurs sont particulirement concerns par la pertinen... | background : improving access to total joint replacement ( tjr ) has been a priority . without robust mechanisms to ensure appropriateness ,
these procedures may be overused , incurring substantial costs . in that context , decision - makers
are particularly concerned with the appropriateness of tjr.objective:while... |
we considered a signal outbreak to be identical to a reported outbreak when 1 ) > 1 signal was triggered within the same period as the first and last case belonging to the particular reported outbreak , 2 ) the signal outbreak was associated with the identical geographic location on the municipal level ( 1 of the 430 m... | to determine efficacy of automatic outbreak detection algorithms ( aodas ) , we analyzed 3,582 aoda signals and 4,427 reports of outbreaks caused by campylobacter spp . or norovirus during 20052006 in germany .
local health departments reported local outbreaks with higher sensitivity and positive predictive value tha... |
since its first full description some 70 years ago , cystic fibrosis has been the focus of considerable clinical and scientific research .
we now know cystic fibrosis to be a common genetic disease , in which the mutation underpinning cf results in altered ion transport .
while this impacts multiple body systems ,... | abstractrecent studies have greatly extended our understanding of the microbiota present in and on the human body . here , advanced sequencing strategies have provided unprecedented analytical power .
the important implications that the emerging data have for human health emphasize the need to intensify research in t... |
although the feet occupy only 5% of the areas of the human body , they control postures
through afferent information obtained through the sense of the soles , provide stability for
maintenance of balance , and absorb impacts1 .
the deformation into flatfoot is induced when the medial longitudinal arch ( mla ) has... | [ purpose ] the purpose of the present study is to apply short foot exercises and arch
support insoles in order to improve the medial longitudinal arch of flatfoot and compare
the results to identify the effects of the foregoing exercises on the dynamic balance of
the feet and the lower limbs .
[ subjects and m... |
pathological activation of a cortical region at a rate of about 1/s can be detected in the electroencephalogram ( eeg ) as periodic lateralized epileptiform discharges ( pleds ) , a term introduced by chatrian et al . in 1964 .
pleds consist of periodic sharp waves , slow waves , and/or multiwave complexes that ar... | drug - induced burst suppression ( dibs ) is bihemispheric and bisymmetric in adults and older children .
however , asymmetric dibs may occur if a pathological process is affecting one hemisphere only or both hemispheres disproportionately .
the usual suspect is a destructive lesion ; an irritative or epileptogenic... |
cerebrovascular disease is the third leading cause of death in the united states ( 1 ) and the second leading cause in korea ( 2 ) .
approximately 88% of strokes are ischemic and about 20% of these originate from large artery stenosis ( 3 , 4 ) . to prevent ischemic stroke ,
carotid endarterectomy has been recommen... | this study aimed to investigate prevalence of asymptomatic carotid artery stenosis ( acas ) in korean patients with peripheral arterial disease ( pad ) and identify predictive factors of acas in patients with pad . between 1994 and 2008 , 546 patients who underwent bypass surgery due to pad were identified in a single ... |
the aspergillus genome database ( aspgd ) is a unique web - based resource focusing on a single genus with a dense representation of sequenced and publicly available whole - genome sequences .
aspgd s mission is to serve the scientific research community by improving the structural and functional annotation associate... | the aspergillus genome database ( aspgd ; http://www.aspgd.org ) is a freely available , web - based resource for researchers studying fungi of the genus aspergillus , which includes organisms of clinical , agricultural and industrial importance .
aspgd curators have now completed comprehensive review of the entire p... |
eligible for the pivus study were all subjects aged 70 years living in the community of uppsala , sweden .
a total of 1,016 subjects participated during 20012004 , giving a participation rate of 50.1% .
the subjects were asked to answer a questionnaire about their medical history , educational level , exercise habi... | objectivephthalates are ubiquitous industrial high - volume chemicals known as ligands to peroxisome proliferator activated receptors ( ppars ) . because ppar- agonists modulate insulin sensitivity and
are used to treat type 2 diabetes , we investigated whether circulating levels of phthalate metabolites are related... |
the invasion of pancreatic cancer ( pca ) cells in intrapancreatic nerves ( neural invasion , ni ) is observed in 100% of patients with pca .
since cancer cells spread along intra- and peripancreatic nerves into the retroperitoneum , ni is critically limiting r0 resections , leading to frequent local recurrence and n... | neural invasion ( ni ) and severe pain are common features in patients with pancreatic cancer ( pca ) . here
, we present the case of a 67-year - old patient with pca whose pre- and postoperative physical situation was clearly dominated by severe pain sensation .
the resected pancreas specimen revealed severe and f... |
the concept of mild cognitive impairment ( mci ) is classified , in older subjects , as a more deficient state than expected for their age and sociocultural level , but not severe enough to define it as dementia .
this state is often characterized as the prodromal phase of several dementia pathologies;1 and so , its ... | backgroundexecutive function impairment ( in particular , mental flexibility ) in the elderly , and in patients with mild cognitive impairment ( mci ) , is strongly correlated with difficulties in performing complex walking tasks .
the aim of this study was to determine if the adaptation of a neuropsychological test ... |
fibrosing mediastinitis , also known as sclerosing mediastinitis or mediastinal fibrosis , is a rare late sequela of a thoracic inflammatory process .
most cases arise from prior histoplasmosis infection , and less commonly from tuberculosis ( tb ) .
fibrosing mediastinitis is characterized by the development of de... | fibrosing mediastinitis is a rare condition defined by the presence of fibrotic mediastinal infiltrates that obliterate normal fat planes .
it is a late complication of a previous granulomatous infection , such as histoplasmosis or tuberculosis ( tb ) . due to its rarity ,
fibrosing mediastinitis is often under - r... |
our analysis was conducted among the 116,671 participants of the nurses health study ii , a longitudinal prospective cohort established in 1989 and described in detail elsewhere ( 8) .
our analysis included women if they reported at least one pregnancy lasting > 6 months between 1991 and 2001 and were free of chronic... | objectivewhether a history of gestational diabetes mellitus ( gdm ) is associated with an increased risk of hypertension after the index pregnancy is not well established.research design and methodswe investigated the association between gdm and subsequent risk of hypertension after the index pregnancy among 25,305 wom... |
physical inactivity is recognized as one of the leading risk factor for mortality around the world that leads to an estimated 3.2 million deaths globally ( 1 ) .
the burden of life style related diseases such as diabetes , coronary artery diseases and hypertension has increased and these diseases are associated with ... | background : sedentary life style and consequent obesity prevail in both developed and developing nations ; gender- and age - independently .
physical inactivity in a population in a life style transition like saudi arabia causes metabolic syndrome with its immediate and long - term complications .
healthcare wor... |
regeneration of complex structures such as appendages has long fascinated and perplexed biologists . historically , understanding regeneration has been approached , often to great effect , through surgical operations , grafting , dissections , and other tools borrowed from embryologists .
more recently , additional i... | there have been notable advances in the scientific understanding of regeneration within the past year alone , including two recently published in bmc biology .
increasingly , progress in the regeneration field is being inspired by comparisons with stem cell biology and enabled by newly developed techniques that allow... |
breast cancer is the most common type of malignant neoplasm affecting women . in poland
there are nearly 15 500 new cases of the disease and over 5200 deaths due to it observed annually .
as it was necessary to provide those suffering from breast cancer with combined highly specialist treatment , it was required th... | |
cleidocranial dysplasia ( ccd , mutational dysostosis , marie - sainton disease , scheuthauer - marie - sainton syndrome , cleidocranial dysostosis and dento - osseous dysplasia ) is a rare ( 1:1,000,000 ) congenital condition affecting skeletal and dental systems .
a wide range of manifestations is reported in ccd c... | cleidocranial dysplasia ( ccd ) is a rare ( 1:1,000,000 ) congenital condition secondary to spontaneous mutation ( 40% ) or autosomal dominant inheritance ( 60% ) affecting skeletal and dental systems .
hypomineralization of the hypoplastic clavicles and/or cranium is the major feature observed by prenatal ultrasound... |
synthetic lethal screens have led to the identification of specific cancer cell vulnerabilities ( barbie et al . , 2009 , possik et al . , 2014 , scholl et al . , 2009 ) .
one such vulnerability has previously been exploited therapeutically in acute lymphoblastic leukemia ( all ) , where leukemic cells lacking asp... | summarycancer cells reprogram their metabolism , altering both uptake and utilization of extracellular nutrients .
we individually depleted amino acid nutrients from isogenic cells expressing commonly activated oncogenes to identify correspondences between nutrient supply and viability . in hme ( human mammary epithe... |
dystonia is a relatively common clinical condition , identified by its characteristic features : sustained muscle contractions , twisting , and abnormal postures .
the term primary dystonia is used to describe dystonia where no cause could be identified ( idiopathic ) , while the term secondary is used to describ... | dystonia is sustained muscle contraction , which may be primary or secondary to other causes .
drugs comprise one of the most important causes for the secondary dystonia , the usual mechanism being a dopaminergic blockade .
there are very few reports describing dystonia resulting from carbamazepine ( cbz ) administ... |
in this article , we present a view of health care spending in the u.s . that focuses on the sectors that finance or sponsor health care .
this view allows us to examine each of the sponsor 's ability to pay for their health care obligations .
the basis for these estimates is the national health expenditure account... | this article provides estimates of health care expenditures by businesses , households , and governments for 1987 - 2003 .
sponsors that finance public and private health insurance programs and other payers face increasing challenges as health care cost rise . their capacity to support rising costs was particularly s... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.