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in recent years , there has been a shift from the traditionally secret experimental data kept by the pharmaceutical industry to a more open - access culture in relation to data sharing ( 1 ) . for this reason
, we have been witnessing a steady increase in public repositories of bioactive small molecules such as chemb... | chemprot-2.0 ( http://www.cbs.dtu.dk/services/chemprot-2.0 ) is a public available compilation of multiple chemical
protein annotation resources integrated with diseases and clinical outcomes information .
the database has been updated to > 1.15 million compounds with 5.32 millions bioactivity measurements for 15 2... |
helicobacter pylori ( h. pylori ) infection leads to gastroduodenal inflammation , peptic ulceration , and gastric carcinoma.1,2 a characteristic event in the infected tissue is the infiltration of the subepithelial gastric lamina propria by phagocytes , mainly neutrophils and macrophages , that produce large amounts o... | helicobacter pylori ( h. pylori ) induced dna damage which may be related to gastric cancer development .
the dna damage response coordinates dna repair , cell - cycle transition , and apoptosis through activation of dna damage response molecules .
the damaged dna is repaired through non - homologous end joining ( ... |
there currently is no standard salvage treatment for locally recurrent adenocarcinoma of the prostate ( cap ) after definitive external beam radiation treatment ( ebrt ) .
patients with recurrent cap are often given androgen deprivation therapy , which is a temporizing measure , at best , and is rarely curative .
s... | even with the technological advances of dose - escalated imrt with the addition of the latest image guidance technologies , local failures still occur .
the combination of mri - based imaging techniques can yield quantitative information that reflects on the biological properties of prostatic tissues .
these techni... |
access cavity preparation is the first step in a series of procedures in endodontic treatment and as such particularly important because it affects all subsequent procedures and finally the outcome .
an appropriately designed access cavity assures unobstructed straight - line access to the apical third of the root ca... | background : ideal access cavity assures unobstructed straight - line access to the apical third of the root canal and preserves tooth structure.aim:the aim of the study was to determine the location and dimensions of access cavity with straight - line access in incisors , canines , and premolars and to evaluate the la... |
we enrolled 33 consecutive patients who underwent 4d us - guided interventional procedures for superficial lesion during a 2-year period ( from september 2002 to october 2004 ) .
they included 17 men and 16 women with an age range of 13 - 82 years ( mean age : 48 years ) .
nineteen patients with initial clinical im... | objectivewe wanted to assess the usefulness of four - dimensional ( 4d ) ultrasonography ( us ) , i.e. , real - time three - dimensional us , as an adjunct for performing various us - guided interventional procedures in superficial lesions.materials and methodsthirty - three patients were referred for us - guided inter... |
cardiovascular diseases are the main causes of sudden death in both men and women . about 50% of cardiovascular mortality is caused by coronary artery disease ( cad ) ( 1 ) .
the major reason for death related to cad is the lethal arrhythmias that appear after the coronary occlusion .
it is known that one of the fa... | objective(s):electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion .
the leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias .
the aim of this stu... |
unexplained , self - reported food hypersensitivity is a prevalent , but poorly understood condition.1 most of the patients present symptoms compatible with irritable bowel syndrome ( ibs ) , and altered metabolic activity of the intestinal microflora has been postulated as a cause.2 conceivably , malfermentation of ... | purpose : enterometabolic disturbances may cause meal - related symptoms . we performed a functional evaluation of the intestinal microflora in patients with unexplained , self - reported food hypersensitivity by measuring fecal short - chain fatty acids ( scfas).patients and methods : thirty - five consecutive patient... |
the olfactory function is generated by chemical signals in the peripheral olfactory system and is important to human survival and perception.1 olfaction has been extensively studied in the context of neurological diseases such as parkinson s disease,1,2 alzheimer s disease,3 multiple sclerosis ( ms),49 and migraine.10 ... | introductionprevious studies have shown that olfactory functioning is affected by multiple sclerosis ( ms ) .
this study assessed the level of the olfactory impairment in early ms by using the sniffin sticks test.methodsthis study included 30 patients with ms and 30 healthy controls .
we collected demographic and c... |
a 30-year - old woman with non - obstructive hypertrophic cardiomyopathy ( hcm ; asymmetric septal hypertrophy morphologic variant ) received a dual - chamber automatic implantable cardioverter defibrillator ( aicd ; boston scientific teligen 100 ) for prevention of sudden cardiac death .
she was diagnosed during fa... | defibrillation testing is no longer routinely performed after automatic implantable cardioverter - defibrillator ( aicd ) implantation
. however , certain subjects undergoing aicd implantation may be at higher risk of undersensing of ventricular arrhythmias resulting in potentially fatal outcomes .
we present the c... |
neurofibromatosis type one ( nf-1 ) is a common inherited disorder affecting from 1 in 2,000 to 1 in 5,000 live births ; it is an autosomal dominant condition characterized by cutaneous lesions , skeletal dysplasias , and the tendency to form soft tissue tumours on peripheral nerves such as plexiform neurofibromas .
... | background .
malignant peripheral nerve sheath tumours ( mpnsts ) are difficult to diagnose and treat and contribute to significant morbidity and mortality for patients with neurofibromatosis-1 ( nf-1 ) .
fdg - pet / ct is being increasingly used as an imaging modality to discriminate between benign and malignant p... |
a 32-year - old male presented with xanthomatous skin lesions , exophthalmos , and diabetes insipidus .
his left retro - orbital mass was partially removed in childhood at another hospital , and he had been diagnosed with hand - schller - christian disease ( hscd ) .
his past medical history included hyperlipidemia... | erdheim - chester disease is a rare non - langerhans form of histiocytosis with multiple organ involvement .
approximately 20% of patients have xanthoma - like lesions , usually on the eyelids .
we report a case of erdheim - chester disease in a 32-year - old male who showed peculiar xanthomatous skin lesions and a... |
traditionally , vitamin d was perceived as a vitamin essential for the regulation of calcium metabolism . in the 19th century
the importance of exposure to the sun was recognized in the prevention and treatment of rickets . at the beginning of 20th century ,
vitamin d was structurally identified and chemically synt... | alteration in vitamin d metabolism has a central role in the pathogenesis of secondary hyperparathyroidism ( shpt ) and is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease ( ckd ) . for more than sixty years , vitamin d ,
nutritional vitamin d ( ergocalcife... |
the past three decades have seen premature births increase to 12.8% of all live births in the united states . as medical advances increase the survival of these preterm infants , the need for neonatal intensive care units ( nicus ) increases concomitantly .
this growth is occurring within a health - care environment ... | objective : to test the efficacy of single family room ( sfr ) neonatal intensive care unit ( nicu ) designs , questions regarding patient medical progress and relative patient safety were explored .
addressing these questions would be of value to hospital staff , administrators and designers alike.study design : thi... |
to date , conventional open gastrectomy for the gastric cancer has been gaining superior popularity than the laparoscopic counterpart .
however , many of the laparoscopic enthusiasts strongly believe that totally laparoscopic or laparoscopy - assisted gastrectomy , either distal or total gastrectomy , may not be wors... | through the advent of surgical techniques and the improvement of laparoscopic tools including the ultrasonic activated scissor , laparoscopic gastrectomy has been increasingly used in far more cases of benign or malignant gastric lesions for the benefit of patients without compromising therapeutic outcomes . even thoug... |
according to the studies of matsuba and shimamura in 1933 ,
respiratory frequency ( rf ) increased by 1.2 times ( all values compared to with those at rest ) when walking 200
m , by 1.5 times during a 200 m trot , and by 45-fold during a 5,0006,400 m canter .
however , these numbers were
obtained by determining... | abstractafter publication of the epic report on equine exercise physiology by matsuba and shimamura in 1933 , papers
on exercise physiology of the racehorse in japan began appearing in scientific journals and increased in
number . in 1944 , respiration during exercise at a walk , trot , and canter was measured by r... |
neuropathic pain is defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system , , and several clinical symptoms are associated with it .
most common are hyperalgesia ( an increased response to a stimulus which is normally painful ; patients with hyperalgesia perceive pain spontaneou... | pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain.about 75 -150 million people in the united states are suffering for chronic pain disorder .
neuropathic pain has a great impact on the human wellbeing .
it is very debilitating and often has an associate... |
a structured questionnaire was distributed to all interns ( categorical and transitional ) , second- and third - year residents of 2 community - based internal medicine ( i m ) residency program in maryland ( md ) and pennsylvania ( pa ) during the period of july 2012 to jan 2013 .
it was also distributed to first- a... | backgroundmedical trainees infrequently use health literacy ( hl ) skills and overestimate their use of plain language and teach back skills .
the aim of this study is to assess if level of training impacts the perception of medical trainees around hl knowledge and skills.methodsa structured questionnaire consisting ... |
the plant fritillaria belongs to the genus fritillaria of the liliaceae family ( known in english as fritillary ) .
the fritillaria bulb has many medical uses , especially in traditional chinese medicine , such as clearing heat , moistening lung , eliminating phlegm , and relieving cough , and for the treatment of ma... | fritillaria is a traditional chinese herbal medicine which can be used to moisten the lungs .
the objective of this study is to develop simple , accurate , and solvent - free methods to discriminate and quantify fritillaria herbs from seven different origins . near infrared spectroscopy ( nirs )
methods are establi... |
structurally complex small molecules have an extraordinary capacity to perform a wide range of useful functions . accessing structural derivatives of these compounds
, however , represents a major bottleneck in efforts to understand and/or optimally harness this capacity .
site - selective functionalization represe... | site - selective functionalizations of complex small molecules can generate targeted derivatives with exceptional step - efficiency , but general strategies for maximizing selectivity in this context are rare . here
we report that site - selectivity can be tuned by simply modifying the electronic nature of the reagen... |
today , prenatal diagnosis of chromosomal anomalies and genetic disorders is routinely performed by invasive procedures ( e.g. , chorionic villus sampling ( cvs ) and amniocentesis ) .
these techniques are highly accurate , but sustain risk of miscarriage , 0,5% . isolation and analysis of intact foetal nucleated cel... | invasive procedures for prenatal diagnosis are associated with increased risk of abortion ; thus , development of noninvasive procedures would be beneficial . based on the observation that embryonic nucleated red blood cell ( nrbc ) crosses the placenta and enters the circulation of pregnant women ,
the ability to id... |
glycogen synthase kinase-3 ( gsk-3 ) is a constitutively active and ubiquitously expressed serine / threonine kinase .
in addition to playing a well - defined role in suppressing the canonical wnt/-catenin signalling pathway , it functions in hedgehog , notch , and several growth factor signalling pathways .
large ... | glycogen synthase kinase-3 ( gsk-3 ) is a well - established downstream component of the phosphatidylinositol 3-kinase ( pi3k ) signalling pathway but is also a key enzyme in negatively regulating the canonical wnt/-catenin signalling pathway .
several recent studies argue that pkb ( protein kinase b)-mediated inhibi... |
we describe here a case of inadvertent corneal perforation and traumatic cataract that occurred during lid anesthesia in a procedure for hordeolum removal .
a 33-year - old woman presented with a sudden visual loss of her left eye .
on ophthalmologic examination , the cornea was perforated and the lens cortex was e... | purposeocular perforation during lid anesthesia is rarely reported .
we describe here a case of inadvertent corneal perforation and traumatic cataract that occurred during lid anesthesia in a procedure for hordeolum removal.methodsa 33-year - old woman presented with a sudden visual loss of her left eye .
she had u... |
it has a considerable negative effect on corneal refractive status , which has been previously reported in various studies on refraction , keratometry , and corneal topography.1 pterygium may cause visual impairment by local flattening of the cornea and inducing with - the - rule astigmatism.2,3 previous studies have d... | backgroundthe purpose of this paper is to report the successful treatment of corneal scarring and high corneal astigmatism secondary to previous pterygium surgery with diamond burr superficial keratectomy using mitomycin c.methodsfour patients with corneal scarring and high corneal astigmatism related to previous ptery... |
choristomas in the head and neck region have been reported in the pharynx , hypopharynx , oral cavity , and middle ear .
they can be cartilage , bone , glial tissue , salivary gland , and thyroid tissue .
the most frequently observed choristoma in the oral cavity are osseous and these are most frequently seen in th... | choristomas are aggregates of microscopically normal cells or tissues in aberrant locations .
cartilaginous choristomas of the oral cavity are rare and occur preferentially on the tongue and less often in sites such as the soft palate and gingiva .
we report a case of cartilaginous choristoma in a 24-year - old mal... |
nonalcoholic steatohepatitis ( nash ) , the progressive form of nonalcoholic fatty liver disease ( nafld ) , is characterized by the presence of > 5% macrovesicular steatosis , inflammation , and liver cell ballooning .
its prevalence is increasing concomitantly with prevalence of obesity and diabetes , thus represen... | sirt1 , ampk , and enos modulate hepatic energy metabolism and inflammation and are key players in the development of nash .
l - leucine , an allosteric sirt1 activator , synergizes with low doses of metformin or sildenafil on the ampk - enos - sirt1 pathway to reverse mild nafld in preclinical mouse models .
here ... |
embolic complications of an atrial myxoma are due to fragments of the myxoma itself or surface emboli
. some cases of cerebral infarction associated with cardiac myxoma have been treated successfully with intravenous thrombolytic therapy [ 1 , 3 , 4 , 5 , 6 ] . however , thrombolytic therapy is not always effective .... | we present a case of cerebral embolism associated with a left atrial myxoma that was treated with intravenous thrombolytic therapy .
a 79-year - old right - handed man with no history of neurological or psychiatric illnesses was referred to our hospital because of confusion .
he had been self - supported in the act... |
autism spectrum disorders ( asds ) are neurodevelopmental disorders characterized by impairment in social interactions , verbal and non - verbal communication skills , and restricted , repetitive and stereotyped patterns of behavior 1 .
recently , centers for disease control and prevention reported the prevalence of ... | autism is a neurodevelopmental disorder with unknown etiology . in some cases , typically developing children regress into clinical symptoms of autism , a condition known as regressive autism .
protein kinases are essential for g - protein - coupled receptor - mediated signal transduction , and are involved in neuron... |
first , research in the field of natural organic nanoparticles is new to material science .
although natural nanostructures with biological functions have been found for many years , natural organic nanoparticles have not been investigated for material properties such as mechanical and optical properties until recent... | though much research has been conducted for nanoparticles , naturally occurring nanoparticles have not yet been well explored for their diverse properties and potential applications . this paper reports the optical absorption and scattering properties of nanoparticles secreted by english ivy .
both experimental and t... |
the plant family myrtaceae includes approximately 150 genera with over 5 500 species ( heywood et al .
2007 ) , amongst which are some important forestry species ( e.g. eucalyptus spp . ) and several fruit crops such as guava ( psidium guajava ) .
some , such as acca sellowiana ( common name feijoa ; in brazil , go... | acca sellowiana ( myrtaceae ) , feijoa ( in brazil , goiaba da serra ) , is a native southern south america tree that produces edible fruits which , although only occasionally cultivated in south america , became a significant fruit crop in new zealand .
recently , during surveys for fungal pathogens of feijoa in sou... |
hepatitis c virus ( hcv ) is a major public health problem that infects approximately 170 million people worldwide .
no vaccine is available for prevention of hcv infection . as a member of the flaviviridae ,
hcv 's positive - sense rna genome contains highly structured 5 and 3 nontranslated regions ( ntrs ) flanki... | it has been reported that ifn-s inhibit hcv replication in vitro . but
the mechanisms of how il-28a conducts antiviral activity and the functions of il-28a - induced isgs ( ifn - stimulated genes ) are not fully understood . in this study , we found that il-28a has the antiviral effect on hcv life cycle including vir... |
among birds , the japanese quail ( coturnix japonica ) is a good model animal
for understanding photoperiodism , because it shows a rapid response to changing day length
.
some studies have indicated that in quail , the
mediobasal hypothalamus ( mbh ) is the center of seasonal reproduction for the following
r... | abstract most species living outside the tropical zone undergo physiological adaptations to
seasonal environmental changes and changing day length ( photoperiod ) ; this phenomenon is
called photoperiodism .
it is well known that the circadian clock is involved in the
regulation of photoperiodism such as seas... |
autogenous , allogenous , or heterogenous bone can be used for contouring bony - defect sites in the oromaxillofacial area .
autogenous bone is typically the best selection because of its osteogenic , osteoconductive , and osteoinductive properties1 - 3 .
tibia can also be used as a bone graft due to its low compli... | objectivesoral and maxillofacial defects often require bone grafts to restore missing tissues .
well - recognized donor sites include the anterior and posterior iliac crest , rib , and intercalvarial diploic bone .
the proximal tibia has also been explored as an alternative donor site .
the use of the tibia for b... |
hypertrophic cardiomyopathy ( hcm ) is the most common genetic cardiovascular disorder , with a prevalence of 0.2 % reported across several regions of the world [ 13 ] , yet current management strategies lack therapy directly targeting the underlying disease process(es ) .
the genetic basis is currently attributed t... | hypertrophic cardiomyopathy ( hcm ) is a cardiovascular genetic disease with a varied clinical presentation and phenotype .
although mutations are typically found in genes coding for sarcomeric proteins , phenotypic derangements extend beyond the myocyte to include the extracellular compartment .
myocardial fibrosi... |
the dictyostelids have fascinated biologists for over 150 years with their ability to assemble up to a million amoebas into a tactile migrating organism , which , after seeking out a site for spore dispersal , transforms into a well - balanced fruiting structure .
the development of a range of molecular genetic and c... | the model organism dictyostelium discoideum is a member of the amoebozoa , one of the six major divisions of eukaryotes .
amoebozoa comprise a wide variety of amoeboid and flagellate organisms with single cells measuring from 5 m to several meters across .
they have adopted many different life styles and sexual beh... |
improper cooking is one of the main factors causing food borne illness [ 15 ] , and a large part , 4060% , of the cases of food borne illness are expected to originate from private households [ 69 ] .
most consumers do not use a meat thermometer [ 10 , 11 ] but determine the doneness of meat most often by cutting the... | the aim of this research was to determine the decimal reduction times of bacteria present on chicken fillet in boiling water .
the experiments were conducted with campylobacter jejuni , salmonella , and escherichia coli .
whole chicken breast fillets were inoculated with the pathogens , stored overnight ( 4c ) , an... |
industrialization and world population are continuously increasing and this demands high energy . as a result , the cost of crude oil , coal , and natural gas is increasing from time to time .
awareness of global climate change and the uncertainty of fossil fuel have thus led to the development of renewable energy . ... | bioethanol is one of the most commonly used biofuels in transportation sector to reduce greenhouse gases .
s. cerevisiae is the most employed yeast for ethanol production at industrial level though ethanol is produced by an array of other yeasts , bacteria , and fungi .
this paper reviews the current and nonmolecul... |
fascial or myofascial unwinding is a process in which a client undergoes a spontaneous reaction in response to the therapist s touch .
fascial unwinding can be used to release fascial restriction by encouraging the body or parts of the body to move to areas of ease .
mosby s dictionary of complementary and altern... | background : fascial or myofascial unwinding is a process in which a client undergoes a spontaneous reaction in response to the therapist s touch . it can be induced by using specific techniques that encourage a client s body to move into areas of ease .
unwinding is a popular technique in massage therapy , but its m... |
follicular dendritic cell sarcomas were first described by monda et al . ( 1 ) and are known to occur predominantly in adults , though they can occur at any age .
extranodal sites include the palate , tonsils , tongue , intra - abdominal soft tissue , liver and spleen ( 2 ) .
only a few reports have discussed the p... | we report computed tomography ( ct ) findings for a rare case of follicular dendritic cell sarcoma of the greater omentum from a 47-year - old female patient .
the tumor presented ash a palpable mass lesion in the umbilical region for the last two months .
multidetector ct scan of the abdomen showed a 14-cm soft - ... |
of the diseases caused by rickettsiae in man , the most wide spread is scrub typhus .
scrub typhus is a zoonosis caused by the agent orientia tsutsugamushi ( o. tsutsugamushi ) transmitted by trombiculid mites ( chigger ) .
the usual clinical presentation is acute febrile illness with rash . because of reports of o... | scrub typhus is the most common zoonosis of public health importance in rural areas of asia , northern australia and pacific islands .
the clinical spectrum of the disease varies from acute febrile illness to multi - organ involvement with systemic complications .
delay in diagnosis and treatment often lead to incr... |
acute angle - closure glaucoma ( aacg ) occurs in predisposed individuals when the pupil is mid dilated .
drugs with 1 adrenergic or anticholinergic effects can precipitate attacks of aacg mainly by mydriasis .
this causes paralysis of ciliary muscle tone which causes aqueous outflow resistance through trabecular m... | angle closure glaucoma is one of the ophthalmic emergencies and treatment has to be given at the earliest .
it is a rare complication of general anesthesia .
a female patient underwent hysterectomy under general anesthesia . following this , patient developed bilateral angle closure glaucoma .
this patient was tr... |
from its bulky long - handle origins , to its current handheld portability , the dermatoscope has developed tremendously , becoming to some dermatologists , what the stethoscope is to the medical physician . while the dermatoscope is most commonly used to assess
melanoma and pigmented lesions , other indications for ... | backgroundinadequate dermoscopy training represents a major barrier to proper dermoscopy use.objectiveto better understand the status of dermoscopy training in us residency programs.methodsa survey was sent to 417 dermatology residents and 118 program directors of dermatology residency programs.resultscomparing differe... |
original micrographs obtained from optical and scanning electron microscopes are presented to show the material microstructure and quality .
a high speed camera is used to capture the hsr compressive behavior of the specimens .
a video is developed at slower playback speed in order to provide better visualization o... | microstructural observations and compressive property datasets of metal matrix syntactic foam core sandwich composite at quasi - static and high strain rate ( hsr ) conditions ( 525845 s1 ) are provided .
the data supplied in this article includes sample preparation procedure prior to scanning electron and optical m... |
carcinoma of the lower uterine segment ( lus ) is a malignant uterine tumor arising between the anatomical internal os and histological internal os of the uterus .
it is a rare tumor that accounts for 33.5% of uterine corpus carcinomas ( 1 ) .
carcinoma of the lus is characterized by deeper myometrial invasion and ... | uterine carcinoma of the lower uterine segment ( lus ) is a rare tumor that accounts for 33.5% of cases of uterine malignant cancer .
the tumor arises from the lower region of the uterine body through the upper region of the cervix .
the present study reported a case of clear cell carcinoma that originated from the... |
toxoplasma is a protozoan parasite that infects up to one - third of the world 's population ( 1 ) .
infection is mainly by ingestion or handing of undercooked or raw meat containing tissue cysts or water or food containing oocysts from the feces of infected cats ( 1 ) .
the prevalence of toxoplasma infection in th... | toxoplasmic encephalitis is a rare infectious complication in patients with hematological malignancy except for allogeneic hematopoietic stem cell transplantation ( hsct ) .
we herein report a case of possible toxoplasmic encephalitis with untreated hairy cell leukemia variant .
magnetic resonance imaging showed mu... |
cas9 ( crispr - associated protein 9 ) is the effector protein of the type ii crispr - cas systems , which represent about 10% of the crispr - cas adaptive - immunity systems and , unlike other crispr - cas types , are present only in bacteria ( 1 ) .
the cas9 protein has a complex domain architecture , with a ruvc -... | abstractbacterial genomes encode numerous homologs of cas9 , the effector protein of the type ii crispr - cas systems .
the homology region includes the arginine - rich helix and the hnh nuclease domain that is inserted into the ruvc - like nuclease domain .
these genes , however , are not linked to cas genes or cr... |
dengue is an arboviral illness caused by four serotypes ( den - v 1 to 4 ) and is transmitted by the bite of an infected aedes mosquito with an incubation period varying from 3 to 14 days .
hepatic failure in dengue has been frequently reported in the pediatric population and is rare in adults .
fulminant hepatic f... | we report a 49-year - old diabetic with dengue hemorrhagic fever who developed fulminant hepatitis , severe coagulopathy , shock , and refractory metabolic acidosis and died on the eighth day of illness .
this is the only second report of an adult with fatal fulminant hepatic failure due to dengue , and the first cas... |
cancer cells often rely on subversion of normal metabolic pathways to provide the energy and building blocks for uncontrolled cell division .
such metabolic reprogramming is now appreciated as an enabling hallmark of tumorigenesis and results in the uptake of nutrients for conversion to biomass .
it is becoming inc... | summaryargininosuccinate synthase 1 ( ass1 ) is the rate - limiting enzyme for arginine biosynthesis .
ass1 expression is lost in a range of tumor types , including 50% of malignant pleural mesotheliomas . starving ass1-deficient cells of arginine with arginine blockers such as adi - peg20
can induce selective leth... |
le neisseria meningitidis du srogroupe b ( menb ) a toujours t une cause importante de mningococcie invasive ( mi ) au canada .
depuis ladoption dun vaccin conjugu contre le mningocoque du groupe c , la majorit des mi au canada sont dsormais attribuables au menb .
analyser les donnes pour dterminer la couverture po... | neisseria meningitidis can cause several invasive diseases .
serogroup distribution has been known to be related to geographical differences and , in canada , most invasive meningococcal disease cases have been caused by serogroups b ( menb ) and c. following the introduction of a meningitis c vaccine , most cases ar... |
atherosclerosis takes a huge toll on our society . it is the leading cause of morbidity and mortality in the western world , and growing incidence of atherosclerosis - related diseases
it has become evident that inflammation mediated both by innate and adaptive immunity plays an important role even in the earliest st... | background .
atherosclerosis is a chronic inflammatory disease with atherosclerotic plaques containing inflammatory infiltrates predominantly consisting of monocytes / macrophages and activated t cells .
more recent is the implication of dendritic cells ( dcs ) in the disease .
since dcs were demonstrated in huma... |
in june 2013 , intestinal contents were obtained from a 1-day - old pig with diarrhea on a farm in ohio , usa .
pedv strain pc21a was detected in the sample by reverse transcription pcr ( rt - pcr ) selective for the nucleocapsid gene ( 229557 nt ) .
the partial nucleocapsid gene sequence of pc21a was identical to ... | to understand the progression of porcine epidemic diarrhea virus infection , we inoculated gnotobiotic pigs with a newly emerged us strain , pc21a , of the virus . at 2448 hours postinoculation , the pigs exhibited severe diarrhea and vomiting , fecal shedding , viremia , and severe atrophic enteritis .
these finding... |
paroxysmal dystonias are classified into paroxysmal kinesigenic dystonias ( pkds ) , paroxysmal nonkinesigenic dystonias , paroxysmal exertion induced dystonias ( peds ) , and paroxysmal hypnogenic dystonias .
transient sudden movements triggered by exercise , which may or may not be associated with pain involving th... | paroxysmal dystonias are a group of relatively benign hyperkinetic childhood movement disorders of varied etiology .
mitochondrial diseases are well known to produce persistent dystonias as sequelae , but paroxysmal exertion induced dystonia has been reported in only one case to the best of our knowledge .
two sibl... |
to report a case of third , fourth , and six cranial nerve palsies with antiphospholipid syndrome ( aps ) .
medical records of a 16 year old female diagnosed with idiopathic intracranial hypertension ( iih ) in primary aps were reviewed .
she was unable to depress , adduct , and abduct in left eye and had limited a... | purposeto report a case of third , fourth , and six cranial nerve palsies with antiphospholipid syndrome ( aps).methodsmedical records of a 16 year old female diagnosed with idiopathic intracranial hypertension ( iih ) in primary aps were reviewed.resultsa 16 year old female presented with headache and diplopia .
ocu... |
self - assembly provides facile , bottom - up
access to complex ordered morphologies that can improve material properties ,
such as charge carrier mobility ( ) and conductivity ( ) ,
and lead to novel emergent properties .
much work has traditionally
been focused on self - assembly and processing of materia... | a tetra(aniline)-based
cationic amphiphile , tani - nhc(o)c5h10n(ch3)3+br ( tani - ptab )
was synthesized , and its emeraldine base ( eb ) state
was found to self - assemble into nanowires in aqueous solution .
the
observed self - assembly is described by an isodesmic model , as shown
by temperature - depen... |
schistosomiasis is a parasitic disease that affects 200 million people in different countries , and is frequently considered the second most important parasitic disease after malaria among the infectious diseases of tropical and subtropical countries , while being the third most prevalent parasitic disease in the world... | background .
snails ' species are associated with
transmission parasitic disease as intermediate host .
biological
control stands to be a better alternative to the chemical controls
aimed against snails .
the search of herbal preparations that do
not produce any adverse effects in the non - target organis... |
molecular dating has become an essential tool for understanding the historical scenarios associated with important evolutionary events.1 indeed , the inclusion of divergence time estimates in phylogenetic studies has become increasingly popular in the last decade , and the majority of works addressing macroevolutionary... | divergence time estimation has become an essential tool for understanding macroevolutionary events .
molecular dating aims to obtain reliable inferences , which , within a statistical framework , means jointly increasing the accuracy and precision of estimates .
bayesian dating methods exhibit the propriety of a li... |
this finding is often mistaken for other pathologic processes . whether as a result of intussusception , dunking during routine appendectomy ( figure 1 ) , or even as a described technique to perform an appendectomy without transection , the end result remains the same additional tissue in the cecal base .
unfortu... | appendiceal inversion is an uncommon entity that presents a diagnostic dilemma for the gastroenterologist or surgeon .
we present 2 cases that illustrate scenarios that may be encountered during colonoscopy .
a discussion of the literature on this subject is also presented .
an improved awareness of this conditio... |
the 14 - 3 - 3 protein family is highly conserved and is represented throughout the eukaryotic branch of life .
the proteins were discovered in 1967 during a study of the soluble acidic proteins of the mammalian brain and were named on the basis of fraction number during deae - cellulose chromatography and location... | the major native forms of 14 - 3 - 3s are homo- and hetero - dimers , the biological functions of which are to interact physically with specific client proteins and thereby effect a change in the client . as a result , 14 - 3 - 3s are involved in a vast array of processes such as the response to stress , cell - cycle c... |
obesity has become a primary health issue , worldwide , and has stepped into epidemic scales ( 1 , 2 ) . the prevalence of obesity in iranian adults and children is increasing . taking into account
that childhood obesity increases the risk of adult obesity , these statistics are really menacing for the next generatio... | context : leptin and ghrelin are two important appetite and energy balance - regulating peptides .
common polymorphisms in the genes coding these peptides and their related receptors are shown to be associated with body weight , different markers of obesity and metabolic abnormalities .
this review article aims to ... |
the presented case report describing successful removal of a 16 mm long pulp stone in a single mass from a maxillary left first molar and its endodontic management .
a new set of ultrasonic endodontic tips were used for the removal of significantly large pulp stone in single mass .
removal of such a large pulp ston... | to present a case report describing successful removal of a 16 mm long pulp stone in a single mass from a maxillary left first molar and its endodontic management . in the presented case ,
the conventional approach of dissecting the pulp stone was not considered , as radiographically the calcification was extending u... |
studies have shown that homeless adults experience high disease burden and mortality rates , are frequent ed users , and have high health care expenditures . because the canadian population is aging
, there is a proportionate rise in the population of aging homeless adults , likely resulting in increased hospital uti... | backgroundhomeless adults frequently use emergency departments ( eds ) , yet previous studies investigating ed utilization by the older segment received little attention .
this study sought to characterize older homeless adults who utilized local urban eds.methodsed encounters at three hospitals in hamilton ( ont . )... |
carcinoma of the breast remains the commonest malignancy in women accounting for over 11,000 deaths in the uk each year . with early diagnosis and treatment
, many women may become long - term breast cancer survivors ; however , recurrence and metastasis are quite common .
gastrointestinal tract ( git ) metastasis ... | metastatic spread of breast carcinoma to the colon and rectum is rare .
we report the case of a patient treated for lobular breast carcinoma presenting 17 years later with metastatic breast cancer of the colon . a 63-year - old lady with a past history of right - sided invasive lobular carcinoma of the breast present... |
bradykinesia is one of the cardinal symptoms of parkinson 's disease ( pd ) and is defined as reduced speed when initiating and executing a single movement with progressive reduction of its amplitude , up to complete cessation during repetitive simple movements [ 1 , 2 ] .
pd motor manifestations , including bradykin... | mirror visual feedback ( mvf ) therapy has been applied to improve upper limb function in stroke . when combined with motor training ,
mvf improves the performance of the trained and untrained hand by enhancing the excitability of both primary motor cortices ( m1s ) .
bradykinesia is a typical feature of parkinson ... |
mental disorders are very common in primary care setting : the who collaborative study on psychological problems in general health care ( ppghc ) reported a global prevalence of 24.0% . in this study , that excludes schizophrenia spectrum disorders ,
the most frequent disorders were depression ( 10.4% ) and generaliz... | this study , carried out in the context of a collaborative care program for common mental disorders , is aimed at identifying the predictors of primary care physician ( pcp ) referral to community mental health center ( cmhc ) and patterns of care .
patients with depression or anxiety disorders who had a first contac... |
silver nanoparticles , which are among the most accessible and optoelectronically functional nanomaterials reported to date , can be applied directly to fabricate nanosilver dot arrays to produce localized surface plasmon resonance ( lspr)-coupled fluorescence enhancement . when a surface plasmon is formed on two - dim... | for the improved surface plasmon - coupled photoluminescence emission , a more accessible fabrication method of a controlled nanosilver pattern array was developed by effectively filling the predefined hole array with nanosilver colloid in a uv - curable resin via direct nanoimprinting . when applied to a glass substra... |
the primary aim of this research was to examine the role of social support on the mental health of disabled iranian war veterans . it was hypothesized that veterans with higher social support would experience less mental health problems .
this study also aimed to investigate the association between the different patt... | objectivethe purpose of this study was to examine the role of social support on the mental health of disabled war veterans alongside the role of physical disability and deployment type .
the second aim of the study was to examine the relationship between coping strategies and mental health.method85 disabled iranian w... |
in april 2009 , a 63-year - old woman was admitted to our hospital because of a frontal headache that occurred when she woke up .
the thoracic pain was described as continuous , nonconstrictive , not related to breathing , with no irradiation , and which decreased when she laid down .
her past medical history was m... | large vessels vasculitis and more specifically , giant cell arteritis , is characterized by increased inflammatory markers , headaches and altered clinical status . diagnosis is confirmed by biopsy of temporal arteries showing the presence of granuloma and vasculitis .
we hereby report the case of a patient presentin... |
autism spectrum disorders ( asds ) describe a group of neurodevelopmental conditions in which the individuals face challenges with social engagement and age - appropriate play and fail to develop appropriate peer relationships according to their developmental level .
although young people are frequently recommended t... | autism spectrum disorder ( asd ) indicates several neurodevelopmental impairments which may end in impairments in motor or physical activities .
daily physical activity involvement was investigated in a total of 83 children ( 52 boys and 31 girls ) with asd aged 615 years .
results indicated that only 10 ( 12% ) of... |
periodontitis is a chronic inflammatory disease resulting from the complex interactions between subgingival bacteria and the defense mechanisms of the periodontium .
periodontitis causes the formation of periodontal pockets , alveolar bone resorption , damage to the structures supporting the teeth and , finally , too... | background and aimsperiodontitis is a chronic inflammation that involves nitro - oxidative stress with damaging periodontal structural effects .
we aimed to evaluate the consequences of low - dose cimetidine on nitro - oxidative stress in periodontitis.methodsa rat model of ligature - induced periodontitis was used .... |
acromegaly is a slow progressing disease caused by excessive growth hormone ( gh ) , which is related to a gh secreting pituitary tumor in most cases .
patients with acromegaly generally exhibit acral enlargement , increased skin thickness , and facial bony deformities , including prognathism , nasal bone hypertrophy... | acromegaly is a slowly progressive disease caused by excessive growth hormone ( gh ) , which is related to a gh secreting pituitary tumor in most cases .
herein , we describe the epidemiology , clinical characteristics , and treatment of acromegaly in korea with a literature review .
the average annual incidence of... |
histopathology comprises routine laboratory work associated with pathology specimens that includes mainly grossing and microscopic examination . of the two ,
microscopic examination of the specimen seems to be the favored option , as it is pleasing to the eyes , requires less manual work , and is not associated with ... | grossing and microscopic examination of the received specimens in a histopathological laboratory is a routine procedure for achieving a fi nal diagnosis .
errors in either of the steps may lead to an inaccurate diagnosis since wrong orientation of the specimen may either cause diagnostic delays or pose a diagnostic d... |
electron and energy transfer processes between an atom or molecule and a surface are extremely important for their many applications in physics and chemistry such as , e.g. , surface analytical tools , particle detection , plasma wall interactions , or catalysis .
therefore , a substantial body of work is devoted to ... | in this work we compare characteristics of auger neutralization of he+ ions at noble metal and free - electron metal surfaces . for noble metals , we find that the position of the energy level of he with respect to the fermi level has a non - negligible influence on the values of the calculated auger rates through the ... |
papillary carcinoma is the most common thyroid malignancy and is usually associated with good outcome .
the aggressive histological variants include diffuse sclerosing variant , tall cell , columnar cell , and cobnail variants .
we present a case of follicular variant ( fv ) of papillary carcinoma with renal and lu... | papillary carcinoma is the most common thyroid malignancy .
usual sites of metastasis include lungs and bone , but renal metastasis is very rare . here
we present a case of a follicular variant of papillary carcinoma with renal and lung metastasis at presentation . |
the measurement of intelligence is an important area of research in psychology and , with the increased longevity among americans , cognitive aging has become a pertinent issue .
studies of cognition in older individuals can lead to increased understanding of the role of cognitive decline in everyday functioning amon... | using cognitive data from the health and retirement study and asset health dynamics among the oldest old studies that were collected between 1992 and 2004 , mcardle and colleagues ( 2007 ) found that a two - factor model ( episodic memory and mental status ) fit better than a one - factor model .
the question that wa... |
the human pancreatic adenocarcinoma bxpc-3 ( atcc crl-1687 ) epithelial cell line was grown in rpmi-1640 ( sigma - aldrich , st louis , mo , usa ) supplemented with 10% fetal bovine serum , 1% penicillin / streptomycin and 0.002 insulin transferrin selenium ( life technologies , carlsbad , ca , usa ) cells were... | to study the role of wnt/-catenin signaling in pancreatic adenocarcinoma , human bxpc-3 cell lines deficient of the central canonical wnt signaling protein -catenin were established by using zinc - finger nuclease mediated targeted genomic disruption of the -catenin gene ( ctnnb1 ) .
comparison of the global transcri... |
according to the world health organization report published in 2012 , the estimated number of people living with dementia exceeds 35.6 million worldwide ( alzheimer 's disease international , 2009 ) .
this number is predicted to double by 2030 , and more than triple by 2050 ( alzheimer 's disease international , 2009... | background : individuals with dementia often experience poor quality of life ( qol ) due to behavioral and psychological symptoms of dementia ( bpsd ) .
music therapy can reduce bpsd , but most studies have focused on patients with mild to moderate dementia .
we hypothesized that music intervention would have benef... |
scoliosis is defined as a condition of side - to - side spinal curves that measure greater than
10. the spine of a person with scoliosis shows an s or a c line on an x - ray1 .
the complex 3d deformity of the spine and
the trunk is especially serious in growing healthy children as it influences their
progre... | [ purpose ] this study was performed to confirm physical therapy scoliosis specific
exercises on adolescent idiopathic scoliosis patients .
[ subject and methods ] a 15-year - old
male middle school student with scoliosis .
cobb s angle , angle of rotation of the spine ,
and breathing pattern were measured be... |
the estimated global prevalence for diabetes in 2011 was 366 million , and the disease is expected to affect 552 million people by 2030 ( diabetes u.k . figures ; accessed 09/01/13 ) .
type 2 diabetes ( t2d ) is a complex and multifactorial disease characterised by impaired insulin secretion and insulin resistance ... | more than 65 loci , encoding up to 500 different genes ,
have been implicated by genome - wide association studies ( gwas ) as conferring an increased risk of developing type 2 diabetes ( t2d ) .
whilst mouse models have in the past been central to understanding the mechanisms
through which more penetrant risk ge... |
a 41-year - old man with stage iv malignant melanoma ( mm ) was referred to the renal services with acute renal impairment .
his initial disease had been surgically managed several months previously , but a follow - up surveillance computed tomography ( ct ) scan demonstrated multiple metastases with intra - abdomina... | targeted immune - modulating agents are entering clinical practice in many specialties , providing novel therapeutic possibilities but introducing new potential toxicities .
we present the first reported case , to our knowledge , of immune - mediated nephritis following the administration of tremelimumab ( cp-675 , 2... |
a drug - related problem ( drp ) is defined as an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes . therefore , the definition of a drp includes more types of problems than an adverse drug event reaction ( ade adr ) , which is defined as any unexpec... | background and aim : medication errors can result in drug - related problems ( drps ) .
insight into the frequency , type , and severity of drps could help reduce their incidence .
the aim of the present study was to estimate the prevalence of admissions as a result of drps at the emergency department ( ed ) of a u... |
dental treatment has the ability to basically alter static and dynamic occlusal relationships , while trying to accomplish as near " ideal " occlusion as possible . for dynamic occlusal relationships , there are three main concepts regarding tooth contact during the lateral excursion of mandibular movement :
1 ) bala... | purposeto study the distribution of various occlusal schemes as well as associated static occlusal relationship among thais.materials and methodsthe subjects ' occlusal schemes on the left and right sides were classified as canine protected occlusion , group function , or unclassified according to the definition from g... |
cancer is a major threat to human health . according to the world health organization ( who )
china , which has a large population base , experienced the largest increase in cancer deaths in recent years .
in addition to the traditional chinese cancers of the stomach , esophagus , liver and nasopharyngus , the wes... | abstractcancer is a major disease worldwide and different approaches are needed for its prevention .
previous laboratory and clinical studies suggest that cancer can be prevented by chemicals , including those from the diet . furthermore , epidemiological studies have suggested that deficiencies in certain nutrients ... |
hepatocellular carcinoma ( hcc ) represents 90% of primary liver cancers and typically occurs secondary to chronic liver conditions , including hepatitis b virus ( hbv ) infection , hepatitis c virus ( hcv ) infection , obesity , and alcoholism on a background of cirrhosis . currently , hcc is the sixth most common sol... | backgroundrecent clinical studies have linked polymorphisms in the xeroderma pigmentosum group d ( xpd ) gene , a key repair gene involved in nucleotide excision repair , to increased risk of hepatocellular carcinoma ( hcc ) .
however , the cellular effects of xpd expression in cultured hcc cells remain largely uncha... |
chemokines are heparin - binding proteins with 4 cysteine residues in the conserved positions .
two intermolecular disulfide bonds are formed between the first and third cysteines and between the second and fourth cysteines .
these bonds lead to the formation of triple - stranded -sheet structures , while the carbo... | chemokines were initially identified as bioactive substances , which control the trafficking of inflammatory cells including granulocytes and monocytes / macrophages .
moreover , chemokines have profound impacts on other types of cells associated with inflammatory responses , such as endothelial cells and fibroblasts... |
the health abc cohort consisted of well - functioning community - dwelling older adults age 7079 years .
the flow of subjects for the dexa study and the ct study is summarized in fig .
the consent forms and study protocols were approved by the institutional review boards at each field center .
diagnosed diabetes ... | objectivea loss of skeletal muscle mass is frequently observed in older adults .
the aim of the study was to investigate the impact of type 2 diabetes on the changes in body composition , with particular interest in the skeletal muscle mass.research design and methodswe examined total body composition with dual - ene... |
a very important requirement for any model is its referent , i.e. , the object or process referred to by the model or that which the latter is about ( 20 ) .
the dreyfus model postulates that when individuals acquire a skill through external instruction , they normally pass through several stages . it is undeniable t... | contextthe dreyfus model describes how individuals progress through various levels in their acquisition of skills and subsumes ideas with regard to how individuals learn .
such a model is being accepted almost without debate from physicians to explain the acquisition of clinical skills.objectivesthis paper reviews s... |
as highlighted by the world health organization : the harmful use of alcohol is one of the world s leading health risks .
it is a causal factor in more than 60 major types of diseases and injuries and results in approximately 2.5 million deaths each year ( world health organization , 2011 ) .
alcoholism , also kn... | advances in the fields of genomics and genetics in the last decade have identified a large number of genes that can potentially influence alcohol - drinking behavior in humans as well as animal models .
consequently , the task of identifying efficient molecular targets that could be used to develop effective therapeu... |
cancer is regarded as a disease of older adults with cancer of the colorectum , breast , lung , and prostate constituting the major cancers . little is known and reported in literature about the incidence and patterns of this disease in adolescents and young adults ( ayas ) .
this population poised between children a... | background and objectives : although cancer in adolescents and young adults ( ayas ) is increasingly an area of focus , there is a paucity of clinical and epidemiological data from developing countries .
our objective was to analyze the geographical distribution , sex ratio , histology , and disease patterns of cance... |
in recent clinical studies , curcumin showed its antioxidant , chemopreventive , and anti - inflammatory activity in acute and chronic inflammation both in clinical practice ( used in neurodegenerative , pulmonary , metabolic , autoimmune , and neoplastic diseases ) and in experimental models . in the latter case ,
e... | curcumin has been successfully applied to treat inflammatory conditions in experimental research and in clinical trials .
the purpose of our study is to evaluate the efficacy of an adjunctive - to - traditional treatment with norflo tablets ( curcumin - phosphatidylcholine complex ; meriva ) administered twice a day ... |
supply of nutritional requirements is vital for all patients , especially for who can not meet their nutritional needs normally .
in addition , appropriate and timely nutritional support results in reducing mortality rate in hospitalized patients .
patients of intensive care unit ( icu ) need special medical care i... | background : malnutrition is prevalent among patients hospitalized in intensive care units ( icus ) and causes various complications .
dietary supplementation to provide appropriate nutritional support may reduce the malnutrition and complications through improvement in nutritional status .
this study was carried o... |
estrogens play an important role in regulating cell proliferation and apoptosis in cancer cells of hormone - sensitive tumors in the breast , ovary , endometrium , and other various hormone - sensitive tissues , for example , colon .
they are also important for the pathogenesis of nonmalignant disease , including the... | the extragonadal synthesis of biological active steroid hormones from their inactive precursors in target tissues is named intracrinology . of particular importance for the progression of estrogen - dependent cancers
is the in situ formation of the biological most active estrogen , 17beta - estradiol ( e2 ) . in ca... |
in 2006 , there were an estimated 9.2 million new cases of tuberculosis ( tb ) , the majority occurring in low- and middle - income countries ( lmics ) . diagnosing tb on the basis of clinical and radiological findings alone is known to be inaccurate , particularly in hiv - associated tb .
most lmics rely almost enti... | barriers to global tuberculosis ( tb ) control include multidrug resistance , hiv infection , and weak health systems .
case detection is critical to tb control and is affected by all three of these .
currently , most low- and middle - income countries ( lmics ) rely on direct sputum smear microscopy for diagnosis ... |
the pathologic process leading to coronary artery disease begins early in life , though the clinical consequences of atherosclerosis are apparent mainly in older adults.[13 ] short - term mortality studies showed that younger patients have more favorable prognosis , but long - term studies showed an overall poor progno... | objective : to evaluate the effect of tobacco smoking on the risk of nonfatal acute myocardial infarction in young adults ( 45 years).patient and methods : we conducted a population - based case - control study with 329 incident acute myocardial infarction cases ( 42 women ; 287 men ) , consecutively admitted to the ca... |
we used flemish wild boar sera collected in 2013 , within the frame of disease surveillance that was focused on aujeszky 's disease , classical swine fever , and brucellosis ( 7 ) .
a total of 238 representative sera were obtained by veterinarians from the two flemish wild boar subpopulations in different provinces :... | in the frame of a flemish wildlife surveillance in 2013 , a serological screening was performed on sera from wild boar ( sus scrofa ; n=238 ) in order to detect tick - borne encephalitis virus ( tbev)-specific antibodies .
neutralising antibodies were titrated with a seroneutralisation test ( snt ) , using two cut - ... |
david barker used historical birth records from hertfordshire , england , to pioneer the concept that the origins of adult disease could be strongly associated with fetal environmental exposures in pregnancy that resulted in low birth weight and predicted increased risk for cardiovascular morbidity and mortality in the... | obesity and gestational diabetes mellitus continue to increase worldwide and span the spectrum of age , race , ethnicity , and socioeconomic status .
alarmingly , 1 in 10 infants and toddlers is obese , and 1 in 5 youths is both obese and at risk for metabolic syndrome prior to puberty .
the mechanisms underlying h... |
noise is present in different environments of human society , including the workplace , and may cause irreversible damage to the human body.1 loud noise is present in dentists ' workplaces , whether from the clinical equipment used , such as dental drills , suction tubes , amalgamators , air compressors ( when located ... | introduction high - level noise exposure in dentists ' workplaces may cause damages to the auditory systems .
high - frequency audiometry is an important tool in the investigation in the early diagnosis of hearing loss .
objectives to analyze the auditory thresholds at frequencies from 500 to 16,000 hz of dentis... |
a monteggia lesion is an uncommon injury in a pediatric elbow joint and radial head dislocation associated with traumatic plastic bowing of the ulna , which is classified as a monteggia equivalent lesion , is easily overlooked .
however , a dislocated radial head should be reduced as soon as possible because delayed ... | abstractradial head dislocation associated with plastic bowing of the ulna is classified as a monteggia equivalent lesion .
this injury in children can be treated by closed reduction , but manipulative reduction may not completely correct plastic bowing of the ulna .
we encountered two cases of incomplete reduction... |
this patient had undergone a distal gastrectomy with gastroduodenostomy for early gastric cancer nine years previously and a subtotal gastrectomy with gastrojejunostomy for recurred gastric cancer in the remnant stomach five months previously . according to the 5th american joint committee on cancer ( ajcc ) tnm classi... | traumatic neuroma is a well - known disorder that occurs after trauma or surgery involving the peripheral nerve and develops from a nonneoplastic proliferation of the proximal end of a severed , partially transected , or injured nerve .
we present a case of traumatic neuroma around the celiac trunk after gastrectomy ... |
we used the google trends database to obtain the proportion of all google searches that contained the words
mrsa or staph . staph was included because many news stories refer to mrsa as antibiotic resistant staph .
methicillin - resistant staphylococcus aureus was too infrequently searched to be useful .
g... | the internet is a common source of medical information and has created novel surveillance opportunities .
we assessed the potential for internet - based surveillance of methicillin - resistant staphylococcus aureus and examined the extent to which it reflects trends in hospitalizations and news coverage .
google qu... |
malaria , a disease caused by protozoan parasites of the genus plasmodium , is still considered a serious global public health problem .
there were approximately 198 million cases and 584,000 deaths in 2013 , according to the world health organization ( who ) ; however it has been noted in recent years that there is ... | introduction .
hematological alterations are frequent in malaria patients ; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood . in colombia , with low endemicity and unstable transmission for malaria , with malaria vivax predominance , the hematologi... |
pediatric tb remains a challenging disease to diagnose despite advances in molecular techniques in mycobacterial identification and antigen based tests for latent tb infection .
classical tb symptoms are nonspecific and more so in settings with high hiv prevalence and malnutrition .
childhood tb is characterised ... | the chest radiograph ( cxr ) is considered a key diagnostic tool for pediatric tuberculosis ( tb ) in clinical management and endpoint determination in tb vaccine trials .
we set out to compare interrater agreement for tb diagnosis in western kenya .
a pediatric pulmonologist and radiologist ( experts ) , a medical... |
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