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chronic migraine , understood as the presence of headache during 15 or more days in a month in patients with migraine history , is an important health problem .
it is estimated that about 2% of general population meets the criteria for chronic migraine with or without analgesic overuse [ 2 , 3 ] .
prevalence in wom... | the objective of this study is to analyse our experience in the treatment of refractory chronic migraine ( cm ) with onabotulinumtoxina ( bta ) and specifically in its effects over disabling attacks .
patients with cm and inadequate response or intolerance to oral preventatives were treated with pericranial injection... |
job involvement has been defined as internalizing values of goodness and importance of working among people .
it is a subjective condition that makes people devoted to their work ( 1 ) .
it is a desirable feature that makes people spend energy and do their best in their work and organizational roles ( 2 ) .
alt... | background : several studies are available on organizational commitment of employees in different organizations .
however , the organizational commitment and job involvement of the employees in the prehospital emergency medical system ( pems ) of iran have largely been ignored.objectives:this study aimed to investiga... |
osteoporosis is a chronic skeletal disorder characterized by decreased bone density and changes in bone microarchitecture leading to increased skeletal fragility and risk of low - trauma fractures with associated complications eventually leading to reduced health - related quality of life .
vertebral fracture is the ... | background : one year , prospective , observational study in an indian subpopulation to assess back pain in patients with severe osteoporosis treated with teriparatide or antiresorptives in a clinical setting.materials and methods : one hundred and nineteen teriparatide - nave indian men and postmenopausal women ( mean... |
renal ewing sarcoma ( es ) is a rare small round blue cell tumor ( srbct ) , which predominantly affects adolescents and young adults .
cytogenetically , renal ess commonly harbor characteristic chromosomal translocations , more than 90% of which are reciprocal translocation t ( 11;22 ) ( q24;q12 ) , resulting in an ... | renal ewing sarcoma ( es ) is a rare malignant tumor characterized by fusion of the ewsr1 gene with a member of the ets family of oncogenes , arising at a specific chromosomal translocation .
diagnosis of es can be problematic , especially from cytological or small bioptical specimens because the differential diagnos... |
we prospectively studied consecutive acute nonlacunar middle cerebral artery ( mca ) ischemic stroke patients admitted to our stroke unit from 2008 january to 2010 july who fulfilled criteria to receive intravenous thrombolysis according to our institutional protocol in a standard dose of 0.9 mg / kg .
specific addit... | objectiveinsulin resistance ( ir ) may not only increase stroke risk , but could also contribute to aggravate stroke prognosis . mainly through a derangement in endogenous fibrinolysis , ir could affect the response to intravenous thrombolysis , currently the only therapy proved to be efficacious for acute ischemic str... |
pancreatic cancer causes many digestive symptoms such as abdominal pain , jaundice , nausea , vomiting , hematemesis , melena and so on , by its direct infiltration into the surrounding organs which include the bile duct , duodenum , stomach , jejunum and colon .
it is very important for us to manage these symptoms s... | 2.6% of pancreatic cancer patients have the primary manifestation of gastrointestinal bleeding .
it is not feasible to stop the duodenal hemorrhage caused by the pancreatic cancer infiltration .
a 43-year - old woman who was diagnosed as having pancreatic cancer with multiple hepatic metastases and duodenal infiltr... |
metabolic and electrolyte abnormalities , including hypokalemia , hyperglycemia and lactic acidosis , are associated with theophylline overdose .
we herein report the first case , to our knowledge , of sinus tachycardia , lactic acidosis , hypokalemia and hyperglycemia associated with the usual theophylline dose in a... | metabolic and electrolyte abnormalities , including hypokalemia , hyperglycemia and lactic acidosis , are associated with theophylline overdose . however
, we report an unusual case of sinus tachycardia , lactic acidosis , hypokalemia and hyperglycemia associated with the usual theophylline dose in a patient with ast... |
oxidative stress results when the balance between the production of reactive oxygen species ( ros ) overrides the antioxidant capability of the target cell ; oxidative damage from the interaction of reactive oxygen with critical cellular macromolecules may occur .
ros may interact with and modify cellular protein , l... | |
the
computational ranking of binding affinities of a congeneric series
of ligands to a protein is an invaluable technique in structure - based
drug design . of the many computational methods that have been developed
for this purpose , free energy perturbation ( fep ) calculations , in
combination with molecul... | with
a view to improving the consistency of free energy perturbation calculations
in monte carlo simulations of protein ligand complexes , we
have implemented the replica exchange with solute tempering ( rest )
method in the mcpro software . by augmenting the standard
rest approach with regular attempted jum... |
since human diets contain many components that may work synergistically to prevent or promote disease , assessing that diet quality may be an informative strategy when studying the relation between nutrition and obesity [ 58 ] .
two of these , the healthy eating index ( hei ) and the diet quality index ( dqi ) , were... | background . obesity is considered as a low grade inflammation condition .
the aim of this study was to investigate the effect of nutritional education on diet quality and biomarkers of inflammation in iranian obese women .
method .
sixty obese women voluntarily participated in this randomized clinical trial and ... |
in recent times , the status of adipose tissue has changed from mere source of energy store to endocrine organ on discovery of many adipokines and their role in energy homeostasis .
rbp-4 a new adipose tissue derived cytokine which specifically binds to retinol , has recently been reported to prove a link between obe... | background : retinol binding protein-4 ( bp-4 ) a new adipocytokine , specifically binds to retinol , through experimental studies , reported its link between obesity and insulin resistance ( ir ) .
but till date no studies are available on influence of genetic predisposition of diabetes on rbp-4 expression .
hence... |
the primary outcome was length of time to failure of maintenance of a sbp goal of < 130 mmhg , an ldl cholesterol goal of < 100 mg / dl , or an a1c goal of < 7% in patients with type 2 diabetes after being discharged from a pharmacist - managed ambulatory care clinic to receive usual care .
the secondary goal of the ... | objective .
this study evaluated the ability of patients with type 2 diabetes to maintain systolic blood pressure ( sbp ) , ldl cholesterol , and a1c at goal levels after being discharged from a pharmacist - managed ambulatory care clinic .
the goals of this study were to 1 ) document the length of time to failure ... |
this case illustrates the use of femoral nerve and sciatic nerve peripheral catheters with an elastomeric infusion pump for major intramedullary nailing surgery .
a 36-year - old male with fractures to the left leg bones presented for placement of an intramedullary nail under spinal anesthesia . at the end of the pro... | backgroundthe prevalence of anterior knee pain following intramedullary tibial nail insertion is high .
continuous peripheral nerve blockade is an alternative method of pain control to opiods .
this case illustrates the use of femoral nerve and sciatic nerve peripheral catheters with an elastomeric infusion pump fo... |
over the past years , lithium - ion batteries
have become one of the
most promising energy storage technology addressing a large range
of applications , from hybrid electric vehicles , electric vehicles
to plug - in hybrid electric vehicles , which are essential to reduce
the fossil oil dependency . to meet r... | the
failure mechanism of silicon - based electrodes has been studied
only in a half - cell configuration so far . here ,
a combination of 7li , 19f mas nmr , xps , tof - sims , and stem - eels ,
provides an in - depth characterization of the solid electrolyte interphase
( sei ) formation on the surface of sil... |
humanized monoclonal antibody against cocaine fragment , antigen - binding fragment , crystallizable antibody - dependent cell mediated cytotoxicity peptide n - glycosidase f 7-fluorobenz-2-oxa-1 , 3-diazole-4-sulfonamide non - equilibrium ph gel electrophoresis 3-(n - morpholino)propanesulfonic acid 2-(n - morpholino)... | variations of post - translational modifications are important for stability and in vivo behavior of therapeutic antibodies . a recombinant humanized anti - cocaine monoclonal antibody ( h2e2 )
was characterized for heterogeneity of n - linked glycosylation and disulfide bonds .
in addition , charge heterogeneity ,... |
adult onset still 's disease ( aosd ) is a rare , clinical entity characterized by spiking fever , evanescent rash , arthralgia or arthritis , and neutrophilic granulocytosis with negative rheumatoid factor and antinuclear antibody test results1 - 4 ) .
the most common cardiac manifestations associated with aosd are ... | adult onset still 's disease ( aosd ) is an uncommon acute systemic inflammatory disease of unknown origin .
the clinical features include high spiking fever , arthralgia or arthritis , transient maculopapular rash , lymphadenopathy , hepatosplenomegaly , and serositis .
pericarditis is the most common cardiac mani... |
t - cell vaccination is the administration of antigenic material to produce t - cell immunity against certain diseases .
antigens used in vaccinations range from live viruses or bacteria to peptides of proteins associated with the disease target .
edward jenner marked the beginning of modern vaccination by using co... | development of vaccines for infectious diseases has come a long way with recent advancements in adjuvant developments and discovery of new antigens that are capable of eliciting strong immunological responses for sterile eradication of disease .
tuberculosis ( tb ) that kills nearly 2 million of the population every ... |
the anesthetic management of elderly patients undergoing abdominal surgery is focused on minimizing morbidity and mortality in this highrisk group .
although transversus abdominis plane ( tap ) blocks have been used successfully as the primary anesthetic for inguinal hernia surgery , we present a series of cases util... | elderly patients undergoing emergency intra - abdominal surgery are at high risk for morbidity and mortality .
the risks and side - effects associated with intubation and mechanical ventilation or neuraxial anesthesia must be balanced against the need to maintain hemodynamic stability while maximizing pain control . ... |
early ischemic changes ( eic ) on computed tomography ( ct ) represent early cytotoxic edema and possible development of irreversible tissue injury . as reperfusion to
irreversibly injured tissue is not beneficial and can even be harmful if it leads to hemorrhage , european cooperative acute stroke study trials have ... | background and purposewe developed a novel method named gray - matter volume estimate score ( graves ) , measuring early ischemic changes on computed tomography ( ct ) semi - automatically by computer software .
this study aimed to compare graves and alberta stroke program early ct score ( aspects ) with regards to o... |
obesity is increasing rapidly in the american population ; currently 69.2% of all american adults are overweight ( body mass index ( bmi ) 25 kg / m ) or obese ( bmi 30 kg / m ) .
concurrent with this rise in obesity , there is an increase in our aging american population . according to the 2010 us census , more th... | objective . to investigate effects of weight loss on adipokines and health measures in obese older adults with symptomatic knee osteoarthritis
. methods .
participants were randomly assigned to either weight loss ( wl ) ( men : 12 , women : 14 ) or weight stable ( ws ) group ( men : 12 , women : 13 ) . wl intervent... |
it has progressed from removal of the rectum and anus with a permanent colostomy to the present era with total mesorectal excision ( tme ) and sphincter - saving surgery .
improvements in treatment and early detection of rectal cancer indicate that more patients will be treated for rectal cancer and , therefore , mor... | purposethe purpose of this study was to prospectively compare rectal resection ( rr ) with colonic resection on sexual , urinary and bowel function and quality of life in both short - term and long-term.methodseighty-three patients who underwent rr were compared to 53 patients who underwent a colonic resection leaving ... |
chronic myeloid leukemia ( cml ) affects approximately 1.5 million people worldwide and is characterized by the uncontrolled proliferation of myeloid cells in the bone marrow and blood .
the disease hallmark results from a genetic abnormality : a reciprocal chromosomal translocation between the long arms of chromosom... | introduction of tyrosine kinase inhibitors for chronic myeloid leukemia treatment is associated with a 63% probability of maintaining a complete cytogenetic response , meaning that over 30% patients require an alternative methodology to overcome resistance , tolerance , or side effects .
considering the potential of ... |
the mite , laelaps nuttalli , occurs throughout the world as a parasite of the black rat rattus rattus , the brown rat r. norvegicus and occasionally of other rodents and small mammals .
studies on l. nuttalli were mainly concerned with surveys and host - parasite relationships [ 218 ] .
considerable literatures we... | the present scanning electron microscopic ( sem ) study includes the redescription of female laelaps nuttalli with emphasis on its gnathosoma and pulvilli which were rarely described in superfamily dermanyssoidea .
chaetotaxy of dorsal shield revealed 40 pairs of setae , 22 on prosoma and 18 on opisthosoma .
epigyn... |
abnormal uterine bleeding ( aub ) observed in a patient on tamoxifen therapy raises concern for primary endometrial abnormalities including atypical endometrial hyperplasia , endometrial polyps , and endometrial cancer 1 , while metastatic breast cancer ( mbc ) is often overlooked as part of the differential diagnoses ... | key clinical messageabnormal uterine bleeding in a patient on maintenance hormonal therapy for breast cancer should raise concern for endometrial abnormalities including rare uterine metastasis from the breast .
hormonal receptor profile changes in metastatic lesions favoring human epidermal growth factor receptor 2 ... |
it is well - known that stem cells ( human embryonic stem cells , mesenchymal stem cells derived from various human tissue , and induced pluripotent stem cells ) have diverse lineage differentiation potential and self - renewal capacity1,2,3,4,5 .
these cells have been studied extensively for applications in the fiel... | objectivesthe purpose of this study was to investigate the neurogenic differentiation of human dental pulp stem cells ( dpscs ) , periodontal ligament stem cells ( pdlscs ) , and stem cells from apical papilla ( scap).materials and methodsafter induction of neurogenic differentiation using commercial differentiation me... |
alzheimer s disease ( ad ) is a progressive neurodegenerative disease with a great statistical growth in recent years . according to estimations
, the number of people with ad dementia is predicted to become nearly triple by 2050 ( 1 ) .
dramatic increase in ad prevalence has increased the importance of more works ... | background : alzheimer s disease ( ad ) is a progressive neurodegenerative disease with a high prevalence in recent years .
dramatic growth in ad prevalence has increased the importance of more researches on ad treatment .
history has shown that traditional medicine can be a source of inspiration to find new therap... |
hemophilia is an inherited coagulation disorder caused by a genetic defect of x - chromosome .
hemophilia is traditionally classified as mild , moderate , and severe based on the level of coagulation factor in a person 's blood compared to normal individuals .
symptoms of hemophilia include hemarthrosis ( especiall... | background : prerequisite for management of a chronic disease involves knowledge about its complications and their prevention .
hemophilia in adolescents influences all the aspects of their lives and thier performance.objectives:the present study aimed to determine the performance of iranian hemophilic adolescents in... |
, it was initially referred to as the nerve of pinkus . in 1905 , it became classified as terminal because , in other animal species , it was observed to extend into the region of the lamina terminalis ( delineating the anterior wall of the third ventricle and , in its lower section , before the optic chiasma , forming... | it has been known for over a century that these cranial nerves exist , and that they are not typographical errors nor a sensational event reported in the medical literature .
a number of scientific articles on anatomy highlight how textbooks on descriptive anatomy do not always consider variables such as differences ... |
a cross - sectional observational study was conducted amongst patients in a lower - limb orthopaedic clinic in october 2011 .
patients attending this clinic were either awaiting or being followed - up from arthroplasty or soft tissue surgery of the hip or knee .
surgery involving robotic and navigation systems was ... | backgroundtechnology in orthopaedic surgery has become more widespread in the past 20 years , with emerging evidence of its benefits in arthroplasty .
although patients are aware of benefits of conventional joint replacement , little is known on patients ' knowledge of the prevalence , benefits or drawbacks of surger... |
mast cells participate in allergies and inflammation by releasing a variety of chemical mediators , such as histamines , leukotrienes , and platelet - activating factors .
activation of mast cells occurs in immunoglobulin e ( ige)mediated ( called type i allergy reactions or anaphylaxis ) reactions and in non - ige -... | objectives : this study was conducted to clarify the effects of agarwood on histamine release from mast cells in rats and on the scratching behaviors in mice.methods:histamine release from rat mast cells induced by compound 48/80 or concanavalin a ( con a ) and compound 48/80-induced scratching behavior in mice were ex... |
the vaginal swabs obtained as described in depth previously ( 1 ) were stored at 80c until dna extraction for amplification and sequencing .
the first group was a set of 63 healthy women , and a single vaginal swab was taken to define the
the second group was a set of 62 women classified as having bv as was assesse... | backgroundthe composition of the vaginal microbiota is known to be important for health .
when infections occur , antimicrobial therapy is often poorly efficacious.objective and designwe used 16s rrna gene sequencing to characterize changes in the bacterial microbiota following oral antimicrobial and probiotic interv... |
nitric oxide is an important mediator of inflammatory responses in the lung and a key regulator of pulmonary vascular and bronchomotor tone .
we have shown that the inducible nitric oxide synthase ( inos ) isoform is continuously expressed in human airway epithelium at mrna and protein / activity levels in vivo . how... | |
headache can be an accompanying symptom of cerebrovascular diseases ( up to 38% of cases ) , mostly depending on stroke etiology and localization .
it is very common in posterior inferior cerebellar artery infarction with a frequency up to 76% in patients with wallenberg s syndrome .
few papers reported that headac... | stroke can present , among other signs , with headache . here , we describe the case of a man suffering from severe orbitary pain and autonomic dysfunction secondary to dorsolateral medullary ischemia . the anatomical relationship between lesion and symptomatology
could be an indirect sign of hypothalamospinal tract ... |
approximately 170 million people are infected with hepatitis c virus ( hcv ) worldwide and natural history studies show that 520% of patients develop cirrhosis after approximately 20 years of infection .
currently , the pegylated - interferon ( peg - ifn ) plus ribavirin combination therapy has become the standard of... | summarybackgroundwe aimed to assess differences in early viral dynamics following treatment with either peg - ifn2a or peg - ifn2b in combination with ribavirin in patients with chronic genotype 1b hcv infection.material/methodssixty-one patients in the peg - ifn2a + ribavirin treatment ( group 2a ) and 88 patients in ... |
metastases of solid tumors of the kidney are occasionally seen in terminally ill patients with disseminated cancer .
renal involvement by metastatic cancer ranges from 3 to 8% based on autopsy series [ 1 , 2 ] .
secondary renal neoplasms are typically identified in the tubulointerstitial compartment , whereas intra... | intraglomerular metastasis is a rare manifestation of disseminated malignancies .
we present here a case of intraglomerular metastatic carcinoma diagnosed as an incidental finding on a kidney biopsy in a 62-year - old male presenting with acute renal failure and metastatic penile squamous cell carcinoma . a prolifera... |
december 2013 , from 125 hospitals throughout the country , we collected 301 serum samples from hospitalized persons who had sfts signs and symptoms , such as high fever ( temperatures > 38c ) , vomiting , diarrhea , and/or fatigue and showed laboratory parameters consistent with thrombocytopenia and/or leukocytopenia ... | during 2013 , severe fever with thrombocytopenia syndrome was diagnosed in 35 persons in south korea .
environmental temperature probably affected the monthly and regional distribution of case - patients within the country .
phylogenetic analysis indicated that the isolates from korea were closely related to isolat... |
in malaysia , emergency medicine ( em ) is a newly recognised specialty with the first postgraduate program starting in 1998 .
emergency department universiti kebangsaan malaysia medical centre ( ed ukmmc ) started the em postgraduate program in 2005 .
the emergency department is made up of various levels of health... | backgroundairway management is an important part of the management of the critically ill and injured patients in the emergency department ( ed ) .
numerous studies from developed countries have demonstrated the competency of emergency doctors in intubation . to date
there have been no published data on intubations ... |
a major focus of today 's research in neuroscience is on the molecular mechanisms leading to age - related neurologic decline .
given the continuous increase in life expectancy in human populations worldwide , finding strategies to maintain health in old age is becoming a matter of increasing socio - economic relevan... | apolipoprotein d ( apod ) is an ancient member of the lipocalin family with a high degree of sequence conservation from insects to mammals .
it is not structurally related to other major apolipoproteins and has been known as a small , soluble carrier protein of lipophilic molecules that is mostly expressed in neurons... |
colorectal cancer is among the most common cancers in the united states , and it has been estimated that more than 50 000 patients died from colorectal cancer in 2007 . consequently , there is great interest in the development of novel therapies for the disease .
in particular , recent studies have investigated the ... | there has been an intensive effort to develop novel therapies for
the treatment of metastatic colorectal cancer ( mcrc ) .
the
anti - epidermal growth factor receptor ( egfr ) antibodies
panitumumab and cetuximab and the anti - vascular endothelial growth
factor ( vegf ) antibody bevacizumab have demonstrated... |
the samples included 1,165 american t1d patients with and without dn selected from the genetics of kidneys in diabetes ( gokind ) study ( 11 ) .
all patients were of european descent , diagnosed before age 31 years , and treated with insulin within 1 year of diagnosis .
the 571 t1d patients ( case subjects ) with d... | objectivehypoxia plays a major pathogenic role in diabetic nephropathy ( dn ) .
we have investigated in this study the effect of hypoxia - inducible factor 1 subunit ( hif1a ) genetic polymorphisms on the development of dn.research design and methodsin 1,165 american type 1 diabetic patients with and without dn sele... |
in recent years , nanometer - sized chalcogenide semiconductors have drawn attention as a component of nanotechnology , mainly due to their physical and chemical properties , heavily dependent on their shape and size .
the ag2s is found amongst the most important chalcogenides and because of its unique optoelectronic... | backgroundin this paper a template - free precipitation method was used as an easy and low cost way to synthesize ag2s semiconductor nanoparticles .
the kramers kronig method ( k k ) and classical dispersion theory was applied to calculate the optical constants of the prepared samples , such as the reflective index... |
prostate cancer is the leading cause of cancer incidence in males and the second cause of male cancer mortality in colombia . in 2012 , 9564 cases were diagnosed in the country .
radiotherapy administered as either external beam radiotherapy ( ebrt ) , high - dose - rate ( hdr ) interstitial brachytherapy or a combin... | purposehigh - dose - rate ( hdr ) brachytherapy has been accepted as an effective and safe method to treat prostate cancer .
the aim of this study was to describe acute toxicity following hdr brachytherapy to the prostate , and to examine the association between dosimetric parameters and urinary toxicity in low - ris... |
c - reactive protein ( crp ) is an acute phase reactant plasma protein produced in response to diverse inflammatory stimuli .
the acute - phase reaction represents an early , non - specific and highly complex reaction of the organism to a variety of injuries such as bacterial , viral or parasitic infection and ischem... | background and objectives : c - reactive protein ( crp ) is a type i acute phase reactant .
a number of studies have reported elevated serum crp levels in periodontitis subjects , which decrease following periodontal therapy .
however , the data of interventional studies on gingival crevicular fluid ( gcf ) levels ... |
much of what we have learned of extracellular dopamine dynamics has been dependent on the neurochemical methods to measure them in vivo .
microdialysis ( westerink , 1995 ; watson et al . , 2006 ) has been used to successfully measure dopamine in various terminal regions .
because the diffusion - based technique ha... | phasic activity of the mesolimbic dopamine pathway burst - firing of dopamine neurons and the resulting dopamine release events at striatal targets have been associated with a variety of motivational events , such as novelty , salient stimuli , social interaction , and reward prediction . over the past decade , advan... |
spontaneous hematomas are more common than post - traumatic epidural hematomas . the annual incidence of spontaneous epidural spinal hematoma has been reported to be 0.1 in 100,000 in the general population , whereas , in the pediatric population , this incidence is significantly lower .
only 40 pediatric cases have ... | an 8-month - old male infant had presented with a history of a fall from the crib a fortnight ago .
he had developed progressive weakness of both lower limbs .
on examination , the infant had spastic paraplegia .
magnetic resonance ( mr ) imaging of the cervical spine showed an epidural hematoma extending from th... |
substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish , such as the use of crisprs or morpholinos to inactivate genes . in the absence of robust inbred zebrafish lines
, we generated nhgri-1 , a healthy and fecund strain derived from founder parents we sequen... | |
orthodontic force application leads to periodontal ligament tissue injury and the initiation of acute inflammatory processes .
subsequent production of pro - inflammatory mediators such as prostaglandins , substance p and cytokines plays an important role in the mediation of orthodontic pain.1 therefore , it is recom... | objective : to investigate and compare the effects of superelastic nickel titanium and multistranded stainless steel archwires on pain during the initial phase of orthodontic treatment.design:a double - blind two - arm parallel design stratified randomized clinical trial.setting:a single centre in india between decemb... |
we conducted a cross - sectional , cohort - type diagnostic accuracy study in adult subjects with type 2 diabetes , who were consecutively recruited from the outpatient clinic of obesity , diabetes , and metabolism in the second department of internal medicine , democritus university of thrace , greece , and the diabet... | objectiveto estimate the accuracy of neuropad for the diagnosis and staging of distal symmetric polyneuropathy ( dpn ) across different stages of neuropathy , using multiple - level likelihood ratios ( lrs ) to interpret the time necessary to complete the color change of the test.research design and methodswe conducted... |
honey bee venom ( hbv , apis mellifera ) is a bitter , colorless liquid , and its active portion contains a mixture of proteins that , cause local inflammation and act as anti - coagulants .
hbv is a complex mixture of enzymes and polypeptides with low molecular weights , and it has been reported to contain the enzym... | objectives : bee venom ( bv ) is a complex mixture of proteins and contains proteins such as phospholipase and melittin , which have an effect on blood clotting and blood clots .
the mechanism of action of honey bee venom ( hbv , apis mellifera ) on human plasma proteins and its anti - thrombotic effect were studied ... |
a synchronous cancer of squamous cell origin found in the esophagus and stomach is very rare among gastrointestinal cancers .
squamous cell carcinomas take up 38% of all esophageal cancers , and it is common in esophagus , but not in stomach.1,2 less than 100 cases were reported until now.3 a synchronous presentation... | synchronous esophageal and gastric cancers with the pathologic features of a squamous cell carcinoma are extremely rare .
a 57-year - old male visited our hospital with a history of hematemesis and was diagnosed with a synchronous cancer .
he underwent a staging work - up , and the resectable lesion in the stomach ... |
insulin - like growth factor - binding protein-1 ( igfbp-1 ) is a member of a family of six igfbps , which have effects on cell metabolism , motility , growth , and survival via igf - dependent and -independent mechanisms .
liver is the most important source of igfbp-1 in the human circulation and hepatic igfbp1 tran... | ghrelin plays key roles in energy homeostasis by central and peripheral actions that include effects on insulin signalling pathways in liver .
insulin is an important inhibitor of production by hepatocytes of insulin - like growth factor - binding protein-1 ( igfbp-1 ) which has an endocrine role to inhibit igf avail... |
paks were discovered 20 years ago by serendipity in the search for new gtpase - activating ( gaps ) proteins for the small rho - like g - proteins ( p21s ) cdc42 and rac1 .
protein bands of ~65 kda , when immobilized on nitrocellulose filters , were found to stabilize the gtp - bound state of rac1 .
the triplet of ... | the p21-activated kinases ( paks ) are a family of ser / thr protein kinases that are represented by six genes in humans ( pak 16 ) , and are found in all eukaryotes sequenced to date .
genetic and knockdown experiments in frogs , fish and mice indicate group i paks are widely expressed , required for multiple tissue... |
sclerosing stromal tumor ( sst ) is a rare benign ovarian neoplasm of the sex cord stromal category first delineated as a distinct ovarian sex cord stromal tumor entity in 1973 by chalvardjian and scully.1 most patients afflicted with sst present with nonspecific symptoms related to an adnexal mass .
it is important ... | sclerosing stromal tumor ( sst ) was first delineated as a distinct ovarian sex cord stromal tumor in 1973 by chalvardjian and scully .
it is a benign neoplasm , distinguished from other ovarian stromal tumors by the production of collagen and a pseudolobular pattern , and it tends to occur in the second and third de... |
unintentional injuries are the most important causes of morbidity and mortality in 15 year - old children , responsible for 750,000 annual mortalities and 400 million severe injuries / year ( 1 - 3 ) . a total of 16 million injured children are admitted to emergency units in the united states each year , 30,000 of whic... | introduction : different factors such as parents knowledge and attitudes regarding preventive measures ( pm ) have a great role in reducing children unintentional home injuries .
the present study aims to evaluate the contributing factors of unintentional home injury prevention in preschool victims presented to the e... |
the frequency of endoscopic surgeries based on laparoscopy or thoracoscopy has increased in recent years and the introduction of new surgical techniques has caused an increased occurrence of pneumothorax . during laparoscopic surgery ,
the use of carbon dioxide to secure the surgical space and visual field can cause ... | we experienced an extremely rare complication during performance of laparoscopic totally extraperitoneal ( tep ) inguinal hernia repair for a 57-year - old healthy man .
about 50 minutes after co2 insufflation , the patient developed tachycardia , hypoxemia , hypercapnia and an increased airway pressure .
right pne... |
the standard management for gsv reflux has been surgical ligation of the sapheno - femoral junction ( sfj ) , with stripping of the gsv . in the recent past
there has been a radical shift towards minimally invasive techniques , one of which is radiofrequency ablation ( rfa ) .
it is clearly effective and less painf... | the incidence of varicose veins in lower limbs is increasing in the indian subcontinent . with the advent of radiofrequency ablation ( rfa ) ,
an effective minimally invasive technique is now available to treat varicose veins .
rfa can be performed with either unipolar or bipolar probes .
we present a simple tech... |
acute pancreatitis ( ap ) is an acute inflammatory disorder with variable severity ranging from self - limited to severe conditions .
it is about 20% of ap experience severe attacks , such as complicate with multiple - organ dysfunction syndrome frequently .
acute renal failure ( arf ) is a common complication of s... | hydrogen ( h2 ) , a new antioxidant , was reported to reduce oh and onoo selectively and inhibit certain proinflammatory mediators to product , without disturbing metabolic redox reactions or ros involved in cell signaling .
we herein aim to explore its protective effects on acute renal injury in sodium taurocholate ... |
there is no consensus on whether antipsychotic or benzodiazepine should be the primary treatment for catatonia associated with schizophrenia . current clinical practice is to resolve catatonia with benzodiazepine or electroconvulsive therapy ( ect ) and then treat underlying associated schizophrenia with antipsychotic ... | a 32-year - old man , diagnosed with catatonic schizophrenia , was treated with risperidone and lorazepam in the general hospital psychiatry setup .
he developed signs of intestinal obstruction , which was diagnosed as paralytic ileus and was treated conservatively along with stopping the offending drug .
risperido... |
the emerging roles of sirtuins , particularly mammalian sirt1 , in regulating both cellular and organismal metabolism were emphasized throughout the meeting .
john denu discussed the role of sirt1 as a major regulator of central cellular metabolic pathways , focusing on new protein targets of this enzyme .
he showe... | from february 1216 , 2012 , leading members of the sirtuin scientific community assembled in tahoe , ca to attend the keystone symposium sirtuins in aging , metabolism , and disease .
it was a vibrant and lively meeting , and in the spirit of keystone symposia , both established sirtuin researchers and those new to ... |
a 64-year - old man with intractable stabbing pain in the distributions of the bilateral gon and lon presented at our hospital . on the day of presentation , he experienced pain all day , and the pain level was 8.9 on the visual analogue scale ( vas ) .
approximately 4 years before admission to our hospital , he had ... | occipital neuralgia is usually defined as paroxysmal stabbing pain in the greater or lesser occipital nerve ( gon or lon ) distribution . in occipital neuralgia patients ,
surgical considerations are carefully taken into account if medical management is ineffective .
however , identification of the occipital artery... |
it is important to maintain the validity of historical control data for assessment of
toxicities , especially carcinogenicity . in carcinogenicity studies for novel pharmaceuticals
and chemicals , peto s test
is commonly employed as one of the tools of statistical analysis
for evaluation of the carcinogenicity ... | historical control data of tumor incidence were collected from the control groups ( 215
animals of each sex ) in four recent carcinogenicity studies that were started between 2005
to 2009 ( terminally sacrificed between 2007 and 2011 ) at bozo research center inc .
( gotemba , shizuoka , japan ) using fischer 344... |
gonadal dysgenesis refers to a variety of clinical conditions in which abnormal development of the fetal gonad is present .
it consists of 46 , xy gonadal dysgenesis , mixed gonadal dysgenesis ( mgd ) , and 45 , x turner syndrome .
mgd , a disorder of sex development ( dsd ) , is defined in individuals who typicall... | highlightsthe clinical presentation of mixed gonadal dysgenesia is known as criptorcidism and undesending testis.mixed gonadal dysgenesia with mosaism 45 , x/46 , x , + mark karyotype are rare case.we present a rare patient case with mixed gonadal dysgenesis as a disorder of sex development ( dsd ) and a new pattern of... |
head and neck cancers account for about 3% of all cancers , and have a fairly good chance of healing . because of certain head and neck anatomy , radiotherapy with or without chemotherapy is one of the main treatment that significantly increased the survival of patients .
however , besides its anti - tumor effects , ... | background : taste abnormalities are common among cancer patients after starting radiotherapy or chemotherapy . considering the role of zinc and reports on its beneficial effects in taste perception , we evaluated the preventive effects of zinc sulfate on radiation - induced taste alterations.materials and methods : in... |
low - back pain is a common musculoskeletal disorder , and many clinicians have tried to
improve trunk stability to prevent and treat low - back pain1 , 2 .
trunk stability is
provided by global muscles , including the rectus abdominis ( ra ) , external oblique ( eo ) ,
internal oblique ( io ) , and erector spi... | [ purpose ] we investigated the effects of unstable conditions on the electromyographic
( emg ) activity of the rectus abdominis ( ra ) and the transverse abdominis internal oblique
( tra - io ) muscles , and lumbar kinematics during unilateral upper - limb resistance exercises
using elastic tubing bands .
[ s... |
cytokine production is a feature of immune stimulation , and alterations in the cytokine profile can influence both the iron status and red blood cell profile .
depending on the cause of the immune stimulation , the purpose of this decrease is to reduce the bioavailability of iron in order to stem uncontrolled cellul... | forty - eight patients were subdivided according to c - reactive protein ( crp ) levels , resulting in 19 patients with normal ( 2.8 2.8 mg
/ l ) and 29 with elevated ( 82.2 76.2 mg
/ l ) crp levels . the elevated crp group had iron and red blood cell ( rbc ) profiles characteristic of chronic immune stimul... |
although metastatic gastric tumors are uncommon , gastric metastasis from ovarian carcinoma is extremely rare because malignant cells from the ovary usually spread through the intraperitoneal cavity.1 - 3 here , we report a case of gastric metastasis from ovarian adenocarcinoma presented as a submucosal tumor without u... | metastatic gastric cancer is extremely rare and gastric metastasis from ovarian adenocarcinoma has rarely been reported .
all of the previously reported metastatic lesions presented as an ulcerative lesions .
we report a case of 49-year - old woman in which gastric metastasis from ovarian adenocarcinoma presented a... |
microorganisms quickly adapt to a changing environment by sensing and responding to environmental cues , such as nutrients . understanding how pathogens sense and utilize nutrients during pathogen - host interactions provides important insights into how to control diseases caused by these microbes .
inositol is a nut... | abstractinositol is an essential nutrient with important structural and signaling functions in eukaryotes .
its role in microbial pathogenesis has been reported in fungi , protozoans , and eubacteria . in a recent article , porollo et al .
[ mbio 5(6):e01834 - 14 , 2014 , doi:10.1128/mbio.01834 - 14 ] demonstrated ... |
many large asian cities
rely on groundwater for their water supply ,
and the abstraction of groundwater has commonly caused the development
of large depression cones .
in addition , some of these cities , exemplified by kolkata and hanoi , are situated on top of aquifers
that are seriously contaminated by geo... | recharge
of red river water into arsenic - contaminated aquifers
below hanoi was investigated .
the groundwater age at 40 m depth in
the aquifer underlying the river was 1.3 0.8 years , determined
by tritium
helium dating .
this corresponds to a vertical flow
rate into the aquifer of 19 m / year .
el... |
a bag of assorted toys was purchased at a local thrift store for six children of a household . upon arriving at their home , the children opened the toys and played with them .
one item ( fig.1 , 2 , 3 ) was a small , gun - like object .
they reported hearing a loud pop and seeing a red cloud of smoke shoot out of ... | we present an unusual case of chlorobenzylidenemalonitrile ( cs ) tear - gas exposure from the unwitting discharge of a personal - protection handgun loaded with cs gas .
the gun was in a bag of toys purchased from a local thrift store and was discharged by a child .
the responding paramedic presumptively identifie... |
malignant melanoma has a unique position in the surgical and oncological fields as it is responsible for 79% of mortalities despite representing less than 5% of cutaneous malignancies .
the considerable variation in recurrence and survival rates among melanoma patients has motivated many researchers to look at differ... | background .
although postoperative complications are common after lymph node dissection , its association with disease recurrence has not yet been fully investigated .
methods .
a retrospective review of a prospectively maintained database was conducted , looking at all malignant melanoma patients with sentinel ... |
the reintroduction of transcranial direct current stimulation ( tdcs ) has kindled great enthusiasm in the field of neurosciences .
tdcs involves application of weak direct electric currents ( up to 2ma ) using scalp electrodes ( usually cathode and anodal electrodes in bipolar stimulation ) .
apart from research i... | transcranial direct current stimulation ( tdcs ) involves application of weak direct electric currents ( up to 2ma ) using scalp electrodes with resultant neuroplasticity modulation by altering the cortical excitability .
though the side effect profile of tdcs is benign and less severe , the utility and safety of tdc... |
ovaries nurture eggs and produce several steroids and peptide hormones that play major role in regulation of reproductive cycle , maintenance of gestation , and initiation of parturition .
there is a relationship between the intrauterine development , pubertal and adulthood variations , anomalies , and pathology of o... | background : there is a relationship between the intrauterine development , pubertal and adulthood variations , anomalies , and pathology of ovaries .
but the entire development spectrum of the ovaries from fetal to menopausal age has not been examined among indian females.objectives:this study was conducted with an ... |
the present study was carried out at a tertiary care referral eye hospital , in south india .
images were obtained from subjects with diabetes who were part of a population - based cross - sectional and follow - up study : sn - dreams , conducted between 2003 and 2006 .
, pennsylvania , usa ) and + 20 d lens ( niko... | aim : to evaluate the efficacy of an automated retinal image grading system in diabetic retinopathy ( dr ) screening.materials and methods : color fundus images of patients of a dr screening project were analyzed for the purpose of the study .
for each eye two set of images were acquired , one centerd on the disk and... |
patients with congestive heart failure ( chf ) often have generalized weakness or weakness of respiratory muscles that can restrict ventilation ( ve ) and lead to the major symptoms of orthopnea , dyspnea on exertion , exercise intolerance , fatigue , or even poor activities of daily living .
some clinical studies ha... | abstractbackgroundcardiopulmonary function can be adversely affected after a cerebrovascular accident in patients with congestive heart failure ( chf ) .
the aim of this study was to investigate the efficacy and feasibility of inspiratory muscle training ( imt ) for stroke patients with chf.methodsa prospective rando... |
the treatment of intraarticular distal humerus fractures is subject of continuous debate in the orthopaedic literature [ 113 ] .
they are uncommon , the anatomy is complex , and bone is frequently comminuted [ 14 , 15 ] .
the nowadays debate is related to the type of treatment ( open reduction and plate osteosynthe... | several alternative approaches have been described to avoid the complications related to the olecranon osteotomy used to treat distal articular humerus fractures .
the published experience with the triceps - sparing approach is scant . in this prospective study ,
a total of 12 patients with an articular humeral fra... |
male sprague dawley rats ( 4 weeks old ; 7580 g ) , purchased from slc , inc .
, were
maintained at a temperature of 2326c and a relative humidity of 5065 % for 2 weeks
after arrival .
rats were divided into five groups ( hfd - control , hfd-5 % ele , hfd-003 %
asp , hfd-01 % asp and hfd-03 % asp ; n 6... | eucommia leaves ( eucommia ulmoides oliver ) contain
chlorogenic acid ( a caffeic acid derivative ) and geniposidic acid and asperuloside ( asp ) ,
iridoid glucosides used in beverages .
we used a metabolic syndrome rat model , produced by
feeding a 35 % high - fat diet ( hfd ) , to examine potential anti - ob... |
tungiasis is a common but highly neglected health problem in many of the economically depressed communities in sub - saharan africa , the caribbean and south america . after penetration , which takes place commonly on the feet , the female sand flea tunga penetrans undergoes an impressing hypertrophy , expelling severa... | tungiasis is caused by infestation with the sand flea ( tunga penetrans ) .
this ectoparasitosis is endemic in economically depressed communities in south american and african countries .
however , data on the epidemiology of tungiasis in tanzania are very limited and the disease does not receive much attention fro... |
epilepsy is one of the most common chronic noncommunicable neurologic disorders found throughout the world .
approximately 50 million people worldwide have epilepsy , and nearly 80% of them live in developing regions .
the annual incidence rates reported are 11/100,000/year in norway , 33/100,000 in italy , and 48/... | objectives : epilepsy is a very common chronic neurological disorder in children throughout the world .
this study was conducted to assess saudi male schoolteachers knowledge of epilepsy and practice in southern saudi arabia.subjects and methods : a cross - sectional descriptive study was conducted among male teacher... |
multiple experimental and clinical data suggest that drugs activating the gabab receptor constitute a new class of pharmacological agents with potential anti - addictive properties : treatment with both orthosteric gabab receptor agonists and positive allosteric modulators ( pams ) of the gabab receptor has indeed been... | recent studies demonstrated that activation of the gabab receptor , either by means of orthosteric agonists or positive allosteric modulators ( pams ) , inhibited different nicotine - related behaviors , including intravenous self - administration and conditioned place preference , in rodents .
the present study inve... |
the identification of permeation enhancers has gained interest in the development of drug delivery systems to improve the bioavailability of therapeutic agents that need to reach the systemic circulation .
tight junctions between adjacent epithelial cells are major absorption barriers for therapeutic agents.1 studies... | backgroundthe identification of permeation enhancers has gained interest in the development of drug delivery systems . a six - mer peptide , h - fcigrl - oh ( at1002 ) ,
is a tight junction modulator with promising permeation - enhancing activity .
at1002 enhances the transport of molecular weight markers or agents... |
the experiments were conducted
on nitroxide - labeled t4l double
mutants using the acert ku - band ( 17.3 ghz ) pds spectrometer ( both
deer and dqc ) .
all t4l mutants used in this study were previously
well - characterized by standard four - pulse deer . | we describe significantly improved long - distance measurements
in
biomolecules by use of the new multipulse double electron electron
spin resonance ( deer ) illustrated with the example of a five - pulse
deer sequence . in this sequence , an extra pulse at the pump frequency
is used compared with standard f... |
almost 30% of renal cancer patients will die after radical treatment because of metastases formation during follow - up .
such recognized prognostic factors as pathological staging ( pt ) and histological grading ( g ) are not sufficient for prognosis .
therefore , it is crucial to identify risk factors to determin... | backgroundthe formation of lymphatic vessels ( lymphangiogenesis ) occurs in tumor tissues and is crucial for tumor development and progression in some cancers .
lymphangiogenesis and its clinical effect on renal cell carcinoma have been less thoroughly investigated in comparison with angiogenesis .
the aim of this... |
smoking of tobacco remains the leading cause of preventable disease and death in the united states resulting in approximately a half million premature deaths annually .
it has been shown that brief physician counseling on the risks of tobacco smoking and the benefits of cessation is an effective method of increasing ... | background : physician counseling on the risks of tobacco smoking and the benefits of cessation has been shown to be an effective method of increasing the rate of smoking cessation . using the help your patients quit smoking : a coaching guide also referred to as the 7a 's of smoking cessation guideline from the ne... |
phenolic compounds are important components of many fruits ,
vegetables , and beverages contributing to their colour and sensory
properties .
epidemiological studies have demonstrated that the
composition of phenol - rich food retards the progression of
arteriosclerosis and reduces the incidence of heart dise... | the effect of two extraction methods of pomegranate juice on its
quality and stability was evaluated . the first method consisted
of separation of the seeds from fruits and centrifugation .
the
second method consisted of squeezing fruit halves with an
electric lemon squeezer . during a period of 72 hours of... |
vaccines are one of the most successful outcomes of modern medicine in improving the global health .
nevertheless , many diseases are still a challenge for vaccine development and the attempt to make new vaccines using more recent technologies has required the use of adjuvants , which enhance the magnitude and modula... | the filamentous bacteriophage fd , codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor dec-205 , is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants . by using a system vac... |
psammomatoid ossifying fibroma ( pof ) is a rare , slowly progressive tumor of the extragnathic craniofacial bones , with a tendency toward locally aggressive behavior .
the pathognomonic histologic feature is the presence of spherical ossicles , which are similar to psammoma bodies .
fibro - osseous lesions compos... | introductionpsammomatoid ossifying fibroma ( pof ) is a rare , slowly progressive tumor of the extragnathic craniofacial bones , with a tendency toward locally aggressive behavior.case reportthe pathognomonic histologic feature is the presence of spherical ossicles , which are similar to psammoma bodies.discussionfibro... |
dry eye syndrome or keratoconjunctivitis sicca is one of the most common diseases in ophthalmology [ 1 , 2 ] . according to published investigations , its prevalence ranged from 5% to 6% in the general populations , and it reached 34% in the elderly .
severe cases can cause serious complications , even loss of visual... | objectives . to investigate whether botulinum toxin type a ( btxa ) could control excessive secretion after submandibular gland ( smg ) transplantation in rabbits and its possible mechanisms . methods .
a new smg transplantation model was established in rabbit .
30 successfully constructed models were randomly assi... |
workers are exposed to hazardous noises high enough to cause hearing loss . according to a study , based on data from the national health interview survey between 1997 and 2003 , 24% of the cases of hearing disorder in the united states are due to occupational exposures . since it is often difficult , for technological... | introduction : present methods of measuring the attenuation of hearing protection devices ( hpds ) have limitations .
objective measurements such as field microphone in real - ear do not assess bone - conducted sound .
psychophysical measurements such as real - ear attenuation at threshold ( reat ) are biased due t... |
cognitive and behavioral impairments are considered to occur frequently in amyotrophic lateral sclerosis / motor neuron disease ( mnd ) . rarely , apraxia has been reported in mnd .
orofacial , or buccofacial , apraxia is characterized by a loss of voluntary control of facial , lingual , pharyngeal and masticatory mu... | introductioncognitive and behavioral impairments are considered to occur frequently in amyotrophic lateral sclerosis / motor neuron disease ( mnd ) . rarely , apraxia has been reported in mnd .
orofacial , or buccofacial , apraxia is characterized by a loss of voluntary control of facial , lingual , pharyngeal and ma... |
therefore , thoracic radiculopathy due to degenerative root canal stenosis is a rare entity . here
, we present a patient with right t2 nerve root canal stenosis with pain in the right axilla and posteromedial arm . he had undergone c56 anterior fusion for cervical spondylosis 5 years prior .
a 60-year - old man p... | thoracic radiculopathy is a rare entity .
symptomatic adjacent - segment disease after anterior cervical fusion occurs commonly in the lower cervical spine segment .
we describe the clinical presentation and treatment of t2 radiculopathy after c56 anterior fusion . a 60-year - old man presented with the right axill... |
despite technical advances in liver surgery in the last decades , the consequences of liver ischemia / reperfusion injury remain a major concern for surgeons .
liver ischemia / reperfusion ( i / r ) injury is a complex cascade of events mediated by numerous inflammatory cells and molecular mediators , resulting in he... | pentoxifylline ( ptx ) has been shown to have beneficial effects on microcirculatory blood flow . in this study
we evaluate the potential hemodynamic and metabolic benefits of ptx during hepatic ischemia .
we also test the hypothesis that portal ptx infusion can minimize the i / r injury when compared to systemic i... |
thiopeptides are potent antibiotics
that inhibit protein synthesis .
they are made by a remarkable post - translational modification process
that transforms a linear peptide into a polycyclic structure .
we present
here the in vitro biosynthesis of the core scaffold of thiomuracin
catalyzed by six proteins ... | |
familial / sporadic hemiplegic migraine ( fhm / shm ) is a rare migraine with aura subtype , usually inherited in an autosomal dominant manner .
mutations on cacna1a on chromosome 19p13 , ( fhm1 ) , atp1a2 on chromosome 1q23 ( fhm2 ) and scn1a genes on chromosome 2q24 ( fhm3 ) were identified as causing fhm [ 2 , 3 ]... | familial hemiplegic migraine ( fhm ) type 1 is a rare monogenic dominant autosomal disease due to cacna1a gene mutations . besides the classical phenotype
, mutations on cacna1a gene are associated with a broader spectrum of clinical features including cerebellar ataxia , making fhm1 a complex channelopathy .
we re... |
the specificity of interactions is mostly determined by structural
and physico - chemical properties of interfaces of interacting proteins .
proteins highly similar in sequence can participate
in different interactions , and even a small number of amino acid substitutions
or insertions / deletions at binding in... | the
crucial prerequisite for proper biological function is the
protein s ability to establish highly selective interactions
with macromolecular partners . a missense mutation that alters the
protein binding affinity may cause significant perturbations or complete
abolishment of the function , potentially lead... |
intracranial germ cell tumors ( gcts ) account for about 2% of brain tumors in children in india .
spread of tumor outside the primary site occurs in 10 - 30% of cases , however , metastasis outside the central nervous system is rare .
we report a case of liver metastasis in an adolescent , 2 years after treatment ... | systemic dissemination of intracranial germ cell tumors ( gcts ) occur only in 3% of cases and the common sites are bone , lungs , and lymph nodes .
metastasis to the liver is rare .
as far as we could find , only six cases of liver metastasis of intracranial gcts have been reported so far .
we report an adolesce... |
stress induced hyperglycemia is a known complication of neonatal sepsis , but sometimes it may become very difficult to distinguish it from neonatal diabetes mellitus .
we present a case of neonatal septicemia with stress induced hyperglycemia mimicking neonatal diabetes mellitus .
extremely high blood sugar values... | stress / sepsis induced transient hyperglycemia in the newborn may present with extremely high blood sugar values and may mimic neonatal diabetes mellitus .
we present a case of neonatal septicemia with stress induced hyperglycemia mimicking neonatal diabetes mellitus .
extremely high blood sugar values upto 1529 m... |
between 3,00,000 and 4,00,000 babies are born each year with serious hemoglobin disorders and up to 90% of these births occur in low and middle income countries .
many of these inherited hemoglobin disorders are malaria resistance genes and in the heterozygous state influence the susceptibility to p. falciparum malar... | inherited hemoglobin disorders like alpha thalassemia and sickle gene are common in the indian subcontinent .
these disorders in the heterozygous state act as malaria resistance genes and influence the susceptibility to plasmodium falciparum malaria .
there is inadequate knowledge about the epidemiology of these ma... |
in south - west nigeria , haemoglobin s has a stable gene frequency of 2.4% homozygote ( hb ss ) and 25% heterozygote ( hbas).1 the point mutation in position 6 of the beta - globin gene results in the replacement of hydrophilic glutamic acid by a hydrophobic valine .
the consequence is haemoglobin s with reduced sol... | background : sickle cell disease ( scd ) is an inherited haemoglobinopathy characterised by recurrent organ hypoxia - reperfusion cycles which may result in repeated organ damage including the lungs and heart . in scd , pulmonary hypertension is a known complication that may precede or complicate acute chest syndrome w... |
integrative health care ( ihc ) has become a popular term used in practice and research to define the blending of complementary and alternative medicine ( cam ) and conventional care as an innovative approach to health care delivery .
to conduct a bibliometric analysis to develop a better understanding of the evoluti... | backgroundintegrative health care ( ihc ) has become a popular term used in practice and research to define the blending of complementary and alternative medicine ( cam ) and conventional care as an innovative approach to health care delivery.purpose and objectivesto conduct a bibliometric analysis to develop a better ... |
human action recognition has been in great demand in the field of pattern recognition , given its direct relation to video surveillance , human - computer interaction , and ambient - assisted living ( aal ) , among other application scenarios . especially in the latter , human behavior analysis ( hba ) , in which human... | this paper presents a novel silhouette - based feature for vision - based human action recognition , which relies on the contour of the silhouette and a radial scheme .
its low - dimensionality and ease of extraction result in an outstanding proficiency for real - time scenarios .
this feature is used in a learning... |
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