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both the dapdiamide family members and their biosynthetic gene cluster were captured by constructing a genomic library of p. agglomerans strain cu0119 and screening for cosmid clones active against erwinia amylovora .
strains of p. agglomerans ( formerly e. herbicola ) have previously been shown to produce numerous a... | construction of a genomic dna library from pantoea agglomerans strain cu0119 and screening against the plant pathogen erwinia amylovora yielded a new family of antibiotics , dapdiamides ae ( 15 ) .
the structures were established through 2d - nmr experiments and mass spectrometry , as well as the synthesis of dapdiam... |
cancer of the cervix uteri is one of the most common cancer in women with an estimate of 527,624 new cases and 265,653 deaths in 2012 .
the mortality rates of cervical cancer worldwide are significantly lower than its rate of incidence . the mortality to incidence ratio of the disease
the squamous cell carcinomas o... | cervical cancer is the second most common female cancer worldwide and a disease of concern due to its high rate of incidence of about 500,000 women annually and is responsible for about 280,000 deaths in a year .
the mortality and morbidity of cervical cancer are reduced through mass screening via pap smear , but thi... |
the pdb ( ) ( 1 ) currently contains > 30 000 3d structures of bio - molecules ( march 22 , 2005 ) .
those who want to look at one of these 3d datasets need additional software to visualize the structure file that is stored in the database .
modern web browsers like mozilla , internet explorer or opera normally dis... | using a web browser without additional software and generating interactive high quality and high resolution images of bio - molecules is no longer a problem . interactive visualization of 3d molecule structures by internet browsers normally is not possible without additional software and the disadvantage of browser - b... |
there is general consensus that breast milk provides the best nutrition for healthy infants as it contains the complete range of nutrients required by infants for healthy growth and development in their first 6 months of life .
in addition to these nutrients , breast milk also encourages increased resilience against ... | background : breast milk contains all the nutrients infants need for their first 6 months of life .
however , only a minority of saudi arabian mothers exclusively breastfeed , so the influencing factors must be examined to encourage more to do so .
the study aimed to determine the prevalence of exclusive breastfeed... |
osteoarthritis ( oa ) in knee joint is the most common reason behind functional disability that leads to lowered quality of life in old age people of india .
some of the objective factors that may influence oa disease severity include but are not limited to age , height , weight , and bmi . in physiotherapy practice ... | purpose . objective of the present study was to see the correlation of subjectively measured koos questionnaire with objectively measured 6-minute walk test ( 6-mwt ) , age , height , weight , and bmi .
participants .
251 subjects with oa knee based on american college of rheumatology criteria . methods . after pas... |
since the isolation of the first human influenza virus in 1933 , controlling infections mediated by this respiratory pathogen has represented a formidable challenge ( webby and webster , 2003 ) .
the impediment stems from the ever - evolving nature of influenza viruses , which enables the viruses to escape pre - exis... | the emergence of a novel influenza a virus strain into humans poses a continuous public health threat .
vaccination is the most effective means of protection against influenza .
the generation of memory b cells and long - lived plasma cells that can maintain protective levels of influenza - specific antibodies for ... |
some investigators have reported an increased prevalence of si and as in patients with bd , but others have found a prevalence that does not differ from that of the general population . the case described here was first diagnosed as ankylosing spondylitis . at that time , he had had recurrent oral ulcer .
several yea... | behcet s disease ( bd ) is a chronic inflammatory condition involving several organs , such as skin , mucous membrane , eye , joint , intestine , lung and central nervous system .
ankylosing spondylitis ( as ) is a prototype of seronegative spondyloarthropathy , and a chronic systemic inflammatory disorder of the axi... |
rna in eukaryotic cells can be classified into five categories : ribosomal rnas ( rrna ) , transfer rnas ( trna ) , messenger rnas ( mrnas ) , long noncoding rnas ( lncrnas ) , and small rnas ( srnas ) . over 90% of the total rna molecules present in a cell
eukaryotic regulatory srnas are a subset of srnas ranging in... | eukaryotic regulatory small rnas ( srnas ) play significant roles in many fundamental cellular processes . as such ,
they have emerged as useful biomarkers for diseases and cell differentiation states .
srna - based biomarkers outperform traditional messenger rna - based biomarkers by testing fewer targets with gre... |
urinary incontinence is not a life - threatening disorder ; however , it can significantly affect a woman 's health . today , elderly women are a rapidly growing segment of the population in the industrialized world , and the prevalence of urinary incontinence increases as patients age .
aging women today are healthi... | purposethe aim of this study was to assess the long - term clinical outcomes of the tension - free vaginal tape ( tvt ) procedure for stress urinary incontinence ( sui ) in elderly women and to identify the factors influencing failure in these cases.materials and methodswomen with sui who underwent a tvt procedure were... |
familial mediterranean fever ( fmf ) is an autosomal recessively inherited disease characterized by recurrent self - limited attacks of fever accompanied by aseptic inflammation of serosal spaces , joints , and skin .
although acute attacks of this disease are self - limited , some patients develop aa type amyloidosi... | backgroundin this study we investigated the potential of neutrophil / lymphocyte ratio ( nlr ) , platelet / lymphocyte ratio ( plr ) , mean platelet volume ( mpv ) , and red cell width distribution ( rdw ) as new inflammatory markers to identify chronic inflammations during symptom - free periods in children diagnosed ... |
there is scarce evidence about any neuroprotective effects of commonly used drug in acute stroke .
bushnell et al . provided a guideline focusing on the risk factors of stroke unique to women , including reproductive factors , metabolic syndrome , obesity , atrial fibrillation , and migraine with aura .
the ten var... | background : stroke has a huge negative impact on the society and more adversely affect women .
there is scarce evidence about any neuroprotective effects of commonly used drug in acute stroke .
bushnell et al . provided a guideline focusing on the risk factors of stroke unique to women , including reproductive fac... |
oligosaccharides and polysaccharides play
a variety of roles in
biology and biochemistry along with proteins and lipids such as storage
of energy , structural roles , chemical markers , and cell protectants ,
among others . in biotechnology
, they are important
in biocompatible and biodegradable materials a... | conformational sampling for a set
of 10 - or -(16)-linked
oligosaccharides has been studied using explicit solvent hamiltonian
replica exchange ( hrex ) simulations and nmr spectroscopy techniques .
validation of the force field and simulation methodology is done by
comparing calculated transglycosidic j coup... |
measurement of luminal pressure - induced neurogenic contraction of whole intestine
in ex vivo : luminal pressure - induced neurogenic contraction of whole intestine
was measured as described previously .
briefly ,
the mid colon and terminal ileum ( about 3 cm ) were isolated from c57bl/6 mice and flushed of
... | maropitant is a neurokinin 1 receptor ( nk1r ) antagonist that is clinically used as a new
anti - emetic drug for dogs .
substance p ( sp ) and its receptor nk1r are considered to
modulate gastrointestinal peristalsis .
in addition , sp works as an inflammatory mediator
in gastrointestinal diseases .
aim of... |
metabolic syndrome is a cluster of biochemical and clinical abnormalities such as abdominal obesity , dyslipidemia , hypertension , and/or impaired blood glucose occurring simultaneously in a single individual.1,2 even though the definition and pathogenesis of metabolic syndrome is still under debate , it is becoming a... | purposemetabolic syndrome is a cluster of biochemical abnormalities including cardiovascular and diabetes risk factors .
the development of diabetes mellitus after renal transplant represents a major posttransplant complication that may adversely affect graft / patient survival .
the aim of this study was to assess... |
acute disseminated encephalomyelitis ( adem ) is an acute demyelinating disorder of the central nervous system ( cns ) which follows an infection or vaccination .
the hallmark of adem is the rapid development of a focal or multifocal neurological disorder with peak dysfunction occurring in several days.[24 ] the diag... | a 9-year - old girl presented to the child guidance clinic with clinical features suggestive of depressive episode of 1 week duration .
there was history of short febrile illness 3 weeks prior to the onset of the depressive symptoms .
mri scan of brain showed features of acute disseminated encephalomyelitis . |
an outbreak with 140 laboratory - confirmed human cases of wnv was centered in the bakersfield area of kern county , california , during 2007 ( incidence = 17.5/100,000 population ) .
this case cluster formed the wnv epicenter for california during 2007 , was the largest mosquito - borne encephalitis virus outbreak i... | adjustable rate mortgages and the downturn in the california housing market caused a 300% increase in notices of delinquency in bakersfield , kern county .
this led to large numbers of neglected swimming pools , which were associated with a 276% increase in the number of human west nile virus cases during the summer ... |
the increasing demand of the development of analytical environmental friendly methods contributes to the miniaturization of existing and well - functioning analysis methods .
the main advantage of micro methods ( hplc and tlc ) is a low consumption of solvents and the fact that the separations are performed on small ... | micro two - dimensional separations were performed on polar bonded stationary phases of the type cyanopropyl - silica using non - aqueous eluents ( polar modifier dissolved in n - heptane ) as the first direction eluents and aqueous eluents ( organic modifier
meoh dissolved in water ) as the second direction eluents ... |
sudden death in epilepsy is common and is associated with repeated frequency of the generalized tonic
clonic seizures and refractory epilepsy that is linked with genetic and acquired causes ( among these ; long qt syndrome ) .
it is attributed to many causes ; one of them is cardiac arrhythmias that resulted from a... | background : sudden death is reported in patients who had a history of epilepsy and some authors believed that is due to cardiac arrhythmias.objectives:this study aimed to predict that the epileptic patients are at risk of serious cardiac arrhythmias by qt - nomogram , tachogram ( lorenz ) , and cardiac restitution plo... |
the gold standard to diagnose malignant pleural effusion is to find malignant cells on cytological examination of pleural fluid or histopathology of pleural biopsy .
cytological analysis has sensitivity from 40% to 87% for malignant pleural effusion , however , the optimal volume of fluid to be sent for cytological a... | background : pleural fluid cytology is a quick and accurate method to diagnose malignant pleural effusions
. the optimal volume of fluid for cytological analysis has not yet been identified , and clinical recommendation based on some published clinical experiences has been to send large volumes of fluid for cytologic... |
prostate carcinoma is caused by development of cancer in the prostate , a gland in the male reproductive system .
metastatic tumors from the primary region to the oral cavity are rare , and account for only 1% of all malignant oral neoplasms .
the proportional frequency of cases with oral and maxillofacial metastas... | the purpose of this study is to report a rare case of mandibular adenocarcinoma that was diagnosed due to metastasis from the prostate .
numb chin syndrome ( ncs ) , which was associated with this case , is also discussed .
computed tomography ( ct ) and an intraoral incisional biopsy of the left mandibular area we... |
dci often develops in divers , compressed air workers , aviators , and astronauts , and is categorized into two pathological conditions , decompression sickness ( dcs ) and air gas embolism ( age ) .
clinical manifestations are caused by regional gas nucleation in fat - containing tissue in patients with dcs and inva... | the mechanism of cerebral decompression sickness ( dcs ) is still unclear .
we report 2 cases of breath - hold divers with cerebral dcs in whom magnetic resonance imaging ( mri ) demonstrated distinctive characteristics .
one case presented right hemiparesthesia , diplopia , and gait disturbance after breath - hold... |
pain is a type of physical experience defined as an unpleasant sensory and mental problem resulting from actual or potential tissue damage , or something that makes people uncomfortable ( international association for the study of pain ) .
peripheral tissue injury or inflammation can cause reversible adaptive changes... | neuropathic pain ( npp ) is intolerable , persistent , and specific type of long - term pain .
it is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients . despite recent progress and growing interest in understanding the pathog... |
infection and disease caused by pathogenic and opportunistic fungi has been increasing over the past decade .
one widespread and severe fungal disease , histoplasmosis , is caused by the dimorphic fungus histoplasma capsulatum .
disease progression then occurs as the fungus transforms to yeast phase and disseminate... | histoplasmosis is a severe dimorphic fungus infection , which is often difficult to diagnose due to similarity in symptoms to other diseases and lack of specific diagnostic tests .
urine samples from histoplasma - antigen - positive patients and appropriate controls were prepared using various sample preparation stra... |
stress urinary incontinence ( sui ) is a socially , emotionally , and physically devastating condition affecting millions of women worldwide .
sui is self - reported in up to 25 % of the adult female population in the united states .
standard treatments include pelvic floor muscle exercise regimes , biofeedback , ... | introduction and hypothesismacroplastique ( polydimethylsiloxane injection ) is a minimally invasive urethral bulking agent with global clinical literature describing its use over 20 years .
this study critically assessed the safety and effectiveness outcomes for adult women treated with macroplastique for stress ur... |
total maxillary setback ( tms ) osteotomy is an orthognathic surgery technique for correcting skeletal problems of bimaxillary protrusion or severe maxillary excess . in cases of skeletal maxillary excess
, maxillary setback can be obtained by using either anterior maxillary segmental osteotomies or tms osteotomy , s... | backgroundthe purpose of this analysis was to evaluate the displacement patterns of the maxilla under parallel and rotational setbacks using the finite element method ( fem).material / methodsa three - dimensional ( 3d ) finite element model of a hemimaxilla was constructed . through a conventional le fort
i osteotom... |
despite more than 30 years of focused scientific efforts worldwide , creating an effective hiv vaccine has proven difficult .
hiv is extraordinary variable ( 1 ) and designing a vaccine able to stimulate immunological responses that will broadly cross - react with circulating variants is a challenge . inducing neutra... | catnap ( compile , analyze and tally nab panels ) is a new web server at los alamos hiv database , created to respond to the newest advances in hiv neutralizing antibody research .
it is a comprehensive platform focusing on neutralizing antibody potencies in conjunction with viral sequences .
catnap integrates neut... |
low back pain , which causes severe morbidity in society , is one of the primary reasons for contacting a doctor . in industrialized societies ,
80% of individuals experience an attack of low back pain at least once in their lifetime [ 35 ] .
while most of these attacks get better with moderate rest , medical treat... | summarybackgroundover the last several decades there has been a general trend toward reduction and minimalization in surgical treatment of chronic back pain , since open surgery brings complications in small and contained disc herniations instead of achieving expected success .
attention has been focussed on percutan... |
inflammatory bowel disease ( ibd ) includes 2 main conditions : ulcerative colitis ( uc ) and crohn disease . uc is a chronic inflammatory disorder characterized by inflammation of the mucosal layer of the colon .
its pathogenesis is not fully understood , but studies have shown that an unknown agent activates immune... | a 73-year - old female of asian origin was diagnosed with ulcerative colitis ( uc ) after initial gastrointestinal symptoms of abdominal pain and bloody diarrhea .
she had a relatively benign course over the subsequent 12 years . in 2009 , she had increased left - sided abdominal pain , bloody diarrhea and progressiv... |
obesity prevalence rates have increased worldwide in the last three decades from 1980 to 2008 , reaching a prevalence of 1014% among the world 's adult population in 2008 . even though obesity rates are higher in upper - middle income and high income countries , they are projected to increase rapidly in developing nati... | objective .
kuwait is among the countries with the highest obesity rates worldwide ; however , little is known about the state of obesity epidemiology research in kuwait . in this paper , we therefore review the findings and methodology of studies on the prevalence , trends and risk factors of obesity in kuwait . met... |
livedoid vasculopathy ( lv ) is a chronic prothrombotic disease of cutaneous microcirculation resulting in cutaneous ischemia and infarction . as a rare disease
, lv has an estimated incidence of ten cases per million.1 lv mostly appears in late adolescence up to the age of 30 years , and patients with lv have an ave... | livedoid vasculopathy ( lv ) is a chronic prothrombotic disease of cutaneous micro - circulation resulting in cutaneous ischemia and infarction . as a rare disease
, lv has an estimated incidence of ten cases per million .
not only correct diagnosis but also effective treatments are very difficult for patients with... |
metastasis of any kind to the patella is rare and usually due to breast or lung malignancy .
symptomatic metastasis to the patella representing the first presentation of an underlying malignancy is rarer still . to our knowledge
this case represents the first documented report of a case of renal cell carcinoma ( rc... | metastasis of any kind to the patella is rare .
metastasis to the patella causing symptoms representing the first presentation of underlying malignancy is rarer still .
we report the case of a previously fit and well 74-year - old male presenting with left anterior knee pain . the initial diagnosis was osteoarthrit... |
diabetes and its complications pose an immense amount of social and economic burden on the health infrastructure and resources throughout the globe .
diabetic nephropathy is the single most common cause of end - stage renal disease ( esrd ) throughout the globe accounting for a whooping 2545% of all patients enrolled... | aims and objectives .
metabolic dysregulation has failed to explain clinical variability of patients with diabetic nephropathy and hence a renewed interest emerged in haemodynamic factors as determinant of progression and development of diabetic nephropathy .
we therefore studied for various factors which can corre... |
the information provided present the equations that relate the concentrations of the various salts in the brines prepared with salt mixtures with the most important characteristics of the fermented tables olives like colour , firmness sensory attributes , and concentration of the mineral contents in the flesh ( table 1... | this article contains processed data related to the research published in fermentation in nutrient salt mixtures affects green spanish - style manzanilla table olives [ 1 ] .
it displays information on the salt substitution by other nutrient salts ( potassium chloride and calcium chloride ) during fermentation of g... |
polycystic ovary syndrome ( pcos ) is the most common cause of anovulatory infertility worldwide .
many women with pcos have difficulty in conceiving naturally . even if patients with pcos are lucky enough to become pregnant , yet they still have to face the distressing conditions of increased risk of early pregnancy... | abstractaim : the aim of the study is to evaluate the effects of metformin on pregnancy outcomes in women with polycystic ovary syndrome ( pcos).methods : we searched electronic databases and bibliographies of relevant papers to identify studies comparing the pregnancy outcomes in the metformin group with those in the ... |
silymarin was provided from ranbaxy ( gurgaon , india ) and sefsol 218 ( propylene glycol - monocaprylic ester ) from nikko chemicals ( tokyo , japan ) as gift samples .
tween 80 ( polyoxyethylene sorbitan monooleate ) was purchased from merck ( schuchardt , hohenbrunn , germany ) .
water was taken from milli - q w... | background : silymarin , a flavonolignan from milk thistle
( silybum marianum ) plant is used almost exclusively for hepatoprotection .
because of its low bioavailability , it was incorporated into a nanoemulsion formulation .
the aim of the present study was to check the stability of silymarin nanoemulsion at d... |
epidemiological data , together with experimental and clinical evidence , appear to support a neuroprotective role of estrogen , accordingly , hormonal therapy in alzheimer s disease ( ad ) , the most prevalent neurodegenerative disorder in the elderly , has been suggested
. however , there is no general consensus on... | experimental evidence supports a protective role of estrogen in the brain . according to the fact that alzheimer s disease ( ad ) is more common in postmenopausal women ,
estrogen treatment has been proposed . however , there is no general consensus on the beneficial effect of estrogen or selective estrogen receptor ... |
muscular pain that starts 1224 hours after unaccustomed exercise , serious resistance
exercise , or excessive use of specific muscles , is known as delayed onset muscle soreness
( doms)1 .
doms increases during the first
24 hours after exercise and , peaks 2448 hours later .
it is characterized by oppressive ... | [ purpose ] the aim of this study was to investigate the effect of vibratory stimulation
on maximal voluntary isometric contraction ( mvic ) from delayed onset muscle soreness
( doms ) . [ subjects ] sixty healthy adults participated in this study .
the exclusion criteria
were orthopedic or neurologic disease .... |
the online version of this article ( doi:10.1007/s40121 - 014 - 0045 - 7 ) contains supplementary material , which is available to authorized users .
good s syndrome is a relatively rare immunodeficiency condition that presents in the fourth or fifth decade of life and is defined by hypogammaglobulinemia in the setti... | good s syndrome is a relatively rare immunodeficiency condition that presents in the fourth or fifth decade of life and is defined by hypogammaglobulinemia in the setting of a thymoma
. the humoral defect may be severe enough to cause an absence in b cells , with a consequent recurrence of sinopulmonary disease , chr... |
gestational diabetes mellitus ( gdm ) is a condition with any level of glucose intolerance which began or was detected for first time during pregnancy despite type of management ; it may also relate to situations that continue after pregnancy .
it affects approximately 7% of pregnancies with an incidence of more than... | gestational diabetes mellitus ( gdm ) complicates a significant number of pregnancies .
blood glucose control improves perinatal outcomes .
medical nutrition therapy is the foundation in management .
aim of this study . to evaluate efficacy of metformin in comparison to insulin for managing gdm . methods . in pro... |
primary lymphedema is usually idiopathic , without a family history , and defined by the age
of onset1 , 2 .
it is characterized by swelling of the tissues and thickening and
hardening of the skin and soft tissue3 , 4 .
the first indication of primary lymphedema
is usually swelling of the feet and ankles , an... | [ purpose ] primary lymphedema occurs because of genetic predisposition and developmental
insufficiency of the lymphatic system .
matrix rhythm therapy was developed as an external
and dynamic method that supplies rhythmic mobilization of the fluids in tissues .
the aim
of the study was to investigate the eff... |
the reactions of the immune system to temperature loss include activities of skin vasomotor , thermogenesis , sweating , and shivering , which is indeed the last immune mechanism , is produced in associated with muscular activities with a frequency of 48 hz , and reinforces the temperature metabolism to 600% compared t... | background : post- and intra - operative shivering is one of the most complications of spinal anesthesia so recommend a suitable drug with at least complications for prevention and control of postoperative shivering .
this current study aimed to compare the preventive effect of hydrocortisone on intra- and post - ope... |
in the past two decades , replacement of missing teeth with implant supported prosthesis has become a widely accepted treatment for the oral rehabilitation of partially or fully edentulous patients .
treatment options can be broadly divided into the fixed implant - supported prosthesis and removable implant - support... | the success of dental implants in patients that have undergone chemo and radiotherapy for a region other than head and neck remain unclear , although some local and systemic factors could be contraindications to dental implant treatment .
as there are very few absolute medical contraindications to dental implant trea... |
single fiber emg ( sfemg ) is a powerful technique to study the pathophysiology of the motor unit .
two types of measurements are made using this technique : fiber density ( fd ) and jitter .
the fd is useful to study the grouping of muscle fibers of a motor unit within its territory . in neuropathy , fd increases ... | we have used computer simulation to study the relationship between the muscle fiber diameter and parameters : peak - to - peak amplitude and duration of the negative peak of the muscle fiber action potential .
we found that the negative peak duration is useful in the determination of fiber diameter via the diameter d... |
fibroblast growth factor-23 ( fgf-23 ) is a hormone secreted by the bone cells - osteocytes and osteoblasts .
its levels increase as the stage of chronic kidney disease ( ckd ) advances , reaching very high levels in ckd stage 5 .
many studies over the last decade have reported fgf-23 as a factor of prognostic sign... | fibroblast growth factor-23 ( fgf-23 ) levels start rising early in patients with chronic kidney disease and is implicated in cardiovascular and overall mortality of hemodialysis patients .
we conducted a prospective observational cohort study in stable dialysis patients looking into the levels of fgf-23 in hemodialy... |
one hundred and eighty three donor candidates underwent an mdct evaluation at seoul national university hospital ( seoul , korea ) between january 2002 and december 2005 .
properly documented surgical reports were available for 153 donor nephrectomies , including 136 open nephrectomies and 17 laparoscopic nephrectomi... | objectiveto determine the accuracy of the use of multi - detector row ct ( mdct ) to predict vascular anatomy in living kidney donors and to reveal the prevalence of vascular variations in a korean population.materials and methodsa total of 153 living kidney donors that had undergone preoperative ct and nephrectomy , e... |
systemic sclerosis ( ssc ) is a disease with a multifaceted pathology which is characterized by an enhanced inflammatory status , vasculopathy , and excessive fibrosis in skin and internal organs .
pulmonary involvement , either lung fibrosis or pulmonary arterial hypertension ( pah ) , is the leading cause of death ... | objective .
systemic sclerosis - associated pulmonary arterial hypertension ( sscpah ) has a disturbed function of the right ventricle ( rv ) when compared to idiopathic pah ( ipah ) .
systemic sclerosis may also affect the heart .
we hypothesize that rv differences may occur at the level of interstitial inflamma... |
the blood brain barrier ( bbb ) separates the parenchyma of the central nervous system from the blood .
quantitative information about the functional integrity of the bbb can be gained by performing dynamic contrast - enhanced mri ( dce - mri ) .
dce - mri has proven valuable in the assessment of many brain pathol... | there is increasing recognition of the importance of blood brain barrier ( bbb ) disruption in aging , dementia , stroke and multiple sclerosis in addition to more commonly - studied pathologies such as tumors .
dynamic contrast - enhanced mri ( dce - mri ) is a method for studying bbb disruption in vivo .
we revi... |
a 77-year - old woman , 156 cm in height and weighing 55 kg , was diagnosed as having angina pectoris and aneurysm of the thoracic aorta , and she was scheduled to undergo coronary artery bypass grafting and aortic arch replacement . she had been a smoker for more than 50 years and had also been diagnosed as having chr... | pulmonary artery ( pa ) rupture caused by a pa swan - ganz catheter is a rare complication but remains fatal in almost 50% of cases .
false aneurysm of the pa is a rare presentation of pa rupture and should be considered as a possible diagnosis in a patient with a new lung mass after pa catheterization .
we present... |
moges tsega : conceived and designed the experiments ; performed the experiments ; analyzed and interpreted the data ; contributed reagents , materials , analysis tools or data ; wrote the paper .
francis dejene : conceived and designed the experiments ; contributed reagents , materials , analysis tools or data .
t... | titanium dioxide ( tio2 ) nanoparticles were prepared by the sol - gel method at different ph values ( 3.26.8 ) with a hydrochloric acid ( hcl ) solution .
raw samples were calcined at 500 c for 2 h. the effects of ph on the structural , morphological and optical properties of tio2 nanoparticles were investigated . a... |
migraine is a chronic neurovascular disease characterized by recurrent headache attacks , lasting for 472 h , associated with nausea and vomiting and accompanied by photophobia and phonophobia .
up to 25% of migraine sufferers report transient attacks of neurological symptoms , known as aura , during the headache . ... | aquaporin4 ( aqp4 ) has an important role in water homeostasis of human brain and a dysfunction of aqp4 could induce pathological conditions in neuronal activity .
the purpose of our work was to evaluate the association of polymorphisms in the aqp4 gene with the risk and the clinical features of migraine .
a total ... |
patients attending the diabetes clinics at austin health routinely undergo regular measurements of renal function and 24-h urine collections for assessment of aer .
patients with impaired renal function ( egfr < 60 ml / min/1.73 m using modification of diet in renal disease formula ) and aer within the normoalbuminur... | objectivethe structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated .
we compared renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate ( egfr ) and measured gfr of < 60 ml / min/1.73 m2 , associated with either norm... |
a regioselective
transition metal - catalyzed cycloisomerization
reaction of boron - containing alkynyl epoxides toward c2- and c3-borylated
furans has been developed .
it was found that the copper catalyst as
well as the gold catalyst with more basic triflate counterion favor
boryl migration toward c3-bory... | |
human epicardial fat is visceral thoracic fat because of its apposition to the heart . like other white adipose tissue loci , such as
the abdominal adipose tissue , epicardial fat might function as a lipid storing depot , as an endocrine organ secreting hormones , and as inflammatory tissue secreting cytokines and ch... | massive deposits of fat around heart are seen in overweight persons and are associated with coronary artery disease .
investigators have focused on the clinical significance of epicardial fat with respect to metabolic effects such as insulin resistance and inflammation , but the mechanical effects , such as constrict... |
we report a case of a patient who presented with anemia , non - productive cough since 15 days with no history of fever and was found to have a lung abscess secondary to a nephrobronchial fistula from asymptomatic pyelonephritis .
the patient was a 45-year - old healthy woman who presented with dry cough and breathle... | there are multiple causes of lung abscess , but the differential rarely includes pyelonephritis as a primary cause leading to lung abscess resulting from the development of a nephrobronchial fistula .
the patient had no urinary symptoms or abdominal pain and the etiology of lung abscess was only incidentally discover... |
a 79-year - old female patient with weight of 58 kg and height of 156 cm visited the hospital for lumbar pain accompanied by referred pain in the left hip and the rear thigh .
she had no special past history but a thyroid isthmectomy to remove thyroid nodule in 2005 .
she was normal in a blood test , a chest x - ra... | tracheal compression by vascular anomalies in adults is uncommon and most related reports are of children .
a 79-year - old woman without any respiratory history underwent a lumbar spine surgery under general anesthesia .
she suddenly developed airway obstruction after a position change from supine to prone .
a f... |
the importance of physical activity ( pa ) in reducing chronic disease and maintaining good health and functional independence has been well documented [ 15 ] . the health benefits of exercise , including enhanced cardiovascular functioning , improved glucose tolerance , and obesity reduction , are well known [ 13 , 6 ... | purpose . to examine relationships between leisure time physical activity ( ltpa ) and health services utilization ( h ) in a nationally representative sample of community - dwelling older adults
. methods .
cross - sectional data from 56,652 canadian community health survey respondents aged 50 years ( 48% m ; 52%... |
sensory impulses triggered by noxious stimuli are delivered to the dorsal horn ( dh ) of spinal cord via primary sensory neurons whose somata are located in the dorsal root ganglia ( drg ) and cranial ganglia .
damage to peripheral nerves often induces a variety of molecular changes that lead to hyperexcitability and... | backgroundgi - interacting protein ( ginip ) is expressed specifically in dorsal root ganglion ( drg ) neurons and functions in modulation of peripheral gamma - aminobutyric acid b receptor ( gbr ) .
genetic deletion of ginip leads to impaired responsiveness to gbr agonist - mediated analgesia in rodent .
it is , h... |
routine cardiac surgery is associated with a low risk of mortality . however , patients undergoing cardiac surgery are increasingly older , with greater comorbidities and consequently the proportion and absolute number of patients at high - risk of postoperative adverse outcomes is increasing [ 2 , 3 ] . as well as
... | introductionpatients undergoing cardiac surgery increasingly have greater comorbidities and subsequently are at higher risk of adverse postoperative outcomes . despite
some evidence suggests that prophylactic intraaortic balloon counterpulsation reduces mortality in selected high - risk patients , its use remains low... |
the reactome project aims to systematically associate human proteins with their molecular and cellular functions in order to create a knowledgebase of human biological reactions , pathways and processes that can be used both as an online encyclopedia and as a systems biology platform for data mining and analysis ( 14 )... | reactome is an open source , expert - authored , manually curated and peer - reviewed database of reactions , pathways and biological processes .
we provide an intuitive web - based user interface to pathway knowledge and a suite of data analysis tools .
the reactome biomart provides biologists and bioinformatician... |
it also gives rise to long - term handicap
giving negative influences on activities of daily living in stroke patients1 , 2 .
there are a lot of stroke sequelae which have bad effects on quality of life in stroke
patients . among these aftereffects ,
hemiparesis defined as motor impairments of the limb
contra... | [ purpose ] the aim of the present study was to investigate effects of skilled reach
training with affected forelimb and treadmill exercise on the expression of neurotrophic
factor following ischemia - induced brain injury in rats . [ subjects and methods ] thirty male
sprague - dawley rats were divided into 3 gr... |
head and neck cancer , including cancers in oral cavity , pharynx ( other than nasopharynx ) , and larynx , is the sixth most common cancer in the world ( parkin et al . , 2005 ) .
it accounted for about 900,000 of cases and 300,000 deaths in 2008 ( ferlay et al . , 2010 ) .
the 5-year survival rate was about 61% i... | previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms ( snps ) , but there are very few documented associations . in the international head and neck cancer epidemiology ( inhance ) consortium , we evaluated associations between snps in the metabolism , ... |
it has been reported that eight to nine percent of total joint arthroplasty ( tja ) patients require revision within ten years of the primary surgery [ 1 , 2 ] .
periprosthetic joint infection ( pji ) following primary total hip arthroplasty ( tha ) and total knee arthroplasty ( tka ) occurs in less than two percent ... | protocols for the screening and decolonization of staphylococcus aureus prior to total joint arthroplasty ( tja ) have become widely adopted .
the goals of this study were to determine : ( 1 ) whether implementation of a screening protocol followed by decolonization with mupirocin / vancomycin and chlorhexidine reduc... |
considering the ongoing changes in the nature of the worlds markets during the last two decades and more competitive pressure on companies bearing a great impact on their operations ( 1,2 ) , the performance management has prompted many organizations to implement new performance measurement and management systems ( 3 )... | with respect to special characteristics of pharmaceutical industry and lack of reported performance measure , this study tries to design an integrated pm model for pharmaceutical companies . for generating this model
; we first identified the key performance indicators ( kpis ) and the key result indicators ( kris ) ... |
mcc or primary neuroendocrine carcinoma of the skin is a rare and aggressive neoplasm with a high metastatic potential .
primary lel carcinoma of the skin is a very uncommon and recently recognized tumor with a favorable outcome [ 2 , 3 ] .
we describe here an exceedingly rare pattern of mcc mimicking lel carcinoma... | merkel cell carcinoma ( mcc ) or primary neuroendocrine carcinoma of the skin is a rare neoplasm with aggressive behavior .
primary lymphoepithelioma - like ( lel ) carcinoma of the skin is a recently described exceptional tumor , with a relatively good prognosis , and is characterized by a neoplastic epithelial comp... |
visual imagery is the ability to generate percept - like images in the absence of retinal input and is therefore a vivid demonstration of retrieving pictorial information from memory .
psychophysical and brain imaging studies have demonstrated functional similarities between visual perception and visual imagery to th... | with the advent of functional brain imaging techniques and recent developments in the analysis of cortical connectivity , the focus of mental imagery studies has shifted from a semi - modular approach to an integrated cortical network perspective .
functional magnetic resonance imaging studies of visual imagery of fa... |
although the consumption of energy drinks is somewhat declining [ 1 , 2 ] compared to previous decades , still a lot of young people , athletes , and especially college students consume energy drinks before practicing , while studying , and before exams because they believe that this improves their performance and memo... | objectives . to assess the effect of red bull on ( 1 ) blood glucose and catecholamine levels , ( 2 ) cardiovascular and respiratory function changes before , during , and after exercise , ( 3 ) reaction time , ( 4 ) cognitive functions , and ( 5 ) response to mental stress test and emotions in young healthy individual... |
this study was carried out in strict accordance with the guidelines of the german animal protection law ( tierschg ) .
all procedures including housing , treatment , and sacrifice by cervical dislocation following isoflurane anesthesia were performed as authorized by and were reported to the responsible state office ... | activation of the ctype lectin receptor dectin1 by glucans triggers multiple signals within dcs that result in activation of innate immunity . while these mechanisms can potently prime cd8 + cytotoxic tcell ( ctl ) responses without additional adjuvants , the dectin1 effector pathways that control ctl induction remain ... |
spontaneous intrahepatic portosystemic shunt ( ipss ) is uncommon , but when it occurs it can cause symptoms mimicking hepatic encephalopathy . when symptoms are mild , the patients can be managed conservatively , with medication and dietary control .
however , in intractable cases , surgical removal of the ipss or s... | intrahepatic portosystemic shunt ( ipss ) is uncommon and usually follows trauma or iatrogenic injury , but spontaneous shunts may also occur , in patients without the evidence of chronic liver disease .
although interventional endovascular management of the shunts is the treatment of choice , a surgical approach can... |
the epic - potsdam study is part of the multicenter prospective cohort study epic ( 13 ) . in potsdam , germany , 27,548 subjects ( 16,644 women and 10,904 men )
the baseline examination included anthropometric measurements , a self - administered validated food - frequency questionnaire , and a personal interview , ... | objective the liver - secreted protein fetuin - a induces insulin resistance in animals , and circulating fetuin - a is elevated in insulin resistance and fatty liver in humans .
we investigated whether plasma fetuin - a levels predict the incidence of type 2 diabetes in a large prospective , population - based stud... |
preterm birth ( ptb ) is the leading cause of infant morbidity and mortality in the world .
the
world health organization ( who ) defines preterm birth as any birth before 37 completed weeks of
gestation or fewer than 259 days since the first day of woman 's last menstrual period ( lmp ) . in developing countries... | introduction .
preterm birth is the leading cause of newborn deaths and the second
leading cause of death in children under five years old .
three - quarters of them could be saved with
current , cost - effective interventions .
the aim of this study was to identify the risk factors of
preterm birth in a se... |
hypertension is one of the most important issues facing the developing countries largely due to its high prevalence in and close relationship with cardiovascular diseases .
hypertension accounts for 7.5 million deaths ( 12.8% of total deaths ) and 57 million disability - adjusted life years across the world annually ... | background : it is assumed that doctor - patient relationship plays an effective role in patients satisfaction , medication adherence , and health outcomes since exploring different aspects of this relationship , such as addressing medication adherence , has rarely been investigated .
therefore , the main aim of the ... |
the human cytosolic enzyme aldehyde dehydrogenase 1 ( aldh1a1 ) functions mainly in acet - aldehyde and neurotransmitter metabolism .
it is also reported to play a major role in the production of retinoic acid , which is important for gene expression and tissue differentiation , and also in cyclophosphamide detoxific... | this paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( aldhiai ) allele .
one hundred and sixty - two indo - trinidadian and 85 afro - trinidadian individuals were genotyped .
a novel aldhiai allele , aldhiai*4 , was identified in an indo - trinidadian alcoholic with an a inserted at ... |
, three isolates of lecanicillium spp . , 20 isolates of beauveria bassiana s.l . , and 21 isolates of cordeceps spp . ) originating from various insect species or soil samples in south korea . a culture plug ( 1 cm ) of
each isolate cultured for 10 days on potato dextrose agar was inoculated into 50 ml potato dextro... | aphids are one of the most destructive pests in crop production such as pepper , cucumber , and eggplants
. the importance of entomopathogenic fungi as alternative pest control agents is increasing .
conidia of entomopathogenic fungi are influenced by environmental conditions , such as temperature and relative humi... |
cleidocranial dysplasia ( ccd ) , also known as marie and sainton 's disease or scheuthauer - mariesainton syndrome or mutational dysostosis .
mutations in the core binding factor alpha-1 gene located on chromosome 6p21 have been suggested to be the cause of ccd.[24 ] rearrangement of long arm of chromosome numbers 6... | scheuthauer - marie - sainton syndrome also known as cleidocranial dysplasia ( ccd ) is an autosomal dominant disorder characteristically presented with multiple supernumerary teeth ; partial or complete absence of the clavicles ; and open sagittal sutures and fontanelles .
this condition was first reported by meckel... |
patients who undergo renal replacement therapy ( rrt ) due to end - stage renal disease ( esrd ) have higher prevalence of comorbidities and increased adjusted mortality risk compared with healthy population .
cardiovascular diseases , infections , and cancers are the most common causes of death in this group of pati... | we evaluated in the 7-year prospective study whether variants in vitamin d pathway genes and calcium - sensing receptor gene ( casr ) are determinants of mortality in hemodialysis ( hd ) patients ( n = 532 ) .
hrm analysis was used for gc rs2298849 , gc rs1155563 , rxra rs10776909 , rxra rs10881578 , and casr rs76525... |
rotator cuff lesions are the most common causes of painful shoulder in the elderly , accounting for up to 70% of cases ( 1 ) .
although magnetic resonance ( mr ) arthrography is reported to be the most sensitive and specific technique for diagnosing rotator cuff tears , ultrasound ( us ) is widely used since it is a... | in evaluating patients complaining of shoulder pain , ultrasonography is an emerging imaging tool due to convenience , low cost , high sensitivity and specificity .
however , normative values of ultrasound dimensions of the shoulder to be compared with pathologic findings in korean adults are not provided yet .
we ... |
reperfusion therapy is the cornerstone of treatment for patients with acute st - elevation myocardial infarction ( stemi ) .
timely reperfusion of the infarct - related coronary artery using fibrinolysis or pci is central to optimal stemi treatment [ 13 , 10 , 15 , 18 ] .
as our treatment center has a skilled pci l... | backgroundgrowing evidence suggests that poor coronary blood flow after primary percutaneous coronary intervention ( pci ) is associated with unfavorable clinical out - come .
we retrospectively evaluated data from our single center
real world patients database of patients undergoing primary pci to determine diffe... |
pronator teres syndrome ( pts ) and anterior interosseous nerve ( ain ) syndrome are proximal median neuropathies of the elbow and forearm .
some authors have suggested that the incidence of proximal median neuropathy is 5% ( 61 of 1128 ) of all median neuropathies , however the actual incidence of pts is very rare a... | we report a rare case of pronator teres syndrome in a young female patient .
she reported that her right hand grip had weakened and development of tingling sensation in the first - third fingers two months previous .
thenar muscle atrophy was prominent , and hypoesthesia was also examined on median nerve territory ... |
population - based cross - sectional study was carried out in the rural and urban field practices area of tertiary care teaching institute at puducherry during 1 may 200730 november 2007 among 1370 adult 20 years of age and above .
prevalence rate of diabetes in india ( urban and rural ) among adults ( 20 year and ab... | background : diabetes mellitus is an emerging global health problem . it is a chronic , noncommunicable , and expensive public health disease.aims and objectives : to determine the prevalence and the risk factors of type 2 diabetes mellitus among the adult population of puducherry , south india.materials and methods : ... |
turner 's syndrome ( ts ) is a symptom complex also called x0 syndrome or bonnevie - ulrich syndrome .
it was first described by turner and ulrich in 1938 , and it represents one of the most frequent chromosomal aberrations .
ts is a relatively common birth defect stemming from a chromosomal disorder associated wit... | complete or partial absence of the second sex chromosome , with or without a mosaic karyotype , is detected in approximately 1 per 2,500 live - born females .
such a cytogenetic finding coupled with clinical features , such as short stature and ovarian failure , supports the diagnosis of turner 's syndrome ( ts ) .
... |
ophthalmic diseases are most commonly treated by topical eye - drop instillation of aqueous products . these formulations ,
however , raise technical problems ( e.g. , solubility , stability , and preservation ) and clinical issues ( efficacy , local toxicity and compliance ) .
conventional aqueous solutions are li... | topical ophthalmic delivery of active ingredients can be achieved using cationic nanoemulsions . in the last decade , novagali pharma has successfully developed and marketed novasorb , an advanced pharmaceutical technology for the treatment of ophthalmic diseases .
this paper describes the main steps in the developme... |
it is characterised by a rapidly progressive glomerulonephritis due to circulating anti - glomerular basement membrane ( anti - gbm ) antibodies .
the subject of this report developed acute pulmonary aspergillosis following exposure to fungal spores in mouldy tree bark whilst gardening and this led to goodpasture 's ... | a non - immunocompromised man developed acute aspergillus pneumonia after spreading mouldy tree bark mulch . despite normal renal function at presentation , he developed rapidly progressive glomerulonephritis with acute kidney injury due to anti - glomerular basement membrane antibodies ( anti - gbm ) 4 weeks later .
... |
for decades most of the visual research has been focused on high acuity central vision , and as a result the role of peripheral vision is underestimated ( e.g. , [ 14 ] ) . for instance , we only recently learned that information about the position of recognized objects within visual space is important and stored in wo... | the paper presents a concept of lifelong plasticity of peripheral vision .
central vision processing is accepted as critical and irreplaceable for normal perception in humans .
while peripheral processing chiefly carries information about motion stimuli features and redirects foveal attention to new objects , it ca... |
evidence exists that chw interventions in underserved populations improve health care management , disease prevention , and health promotion .
community health workers improve management of chronic illnesses such as asthma , diabetes , maternal child health issues , increase health promotion activities such as vacci... | objectives : community health workers ( chws ) serve as a means of improving outcomes for underserved populations . however , their relationship within health care teams is not well studied .
the purpose of this integrative review was to examine published research reports that demonstrated positive health outcomes as... |
glucose transport 1 ( glut-1 ) deficiency is caused by a decrease in the transfer of glucose to the brain due to mutations in the glucose transporter 1 ( slc2a1 ) gene1 ) .
de novo mutations have been identified in the slc2a1 gene , which consists of 10 exons and 9 introns and contains 492 amino acids in 12 transmemb... | glucose transport 1 ( glut-1 ) deficiency is a rare syndrome caused by mutations in the glucose transporter 1 gene ( slc2a1 ) and is characterized by early - onset intractable epilepsy , delayed development , and movement disorder . de novo mutations and several hot spots in n34 , g91 , r126 , r153 , and r333 of exons ... |
specimens : five species of adult salamanders representing five families
were examined in this study ( table 1table 1.specimens used in this studyspecieshabitatsvl * ( mm)amphiuma tridactylumaquatic408434471necturus maculosusaquatic175172168cynops pyrrhogastersemi - aquatic534845hynobius nigrescensterrestrial707273am... | abstracttrunk musculature in urodela species varies by habitat . in this study ,
trunk musculature
was examined in five species of adult salamanders representing three different habitats :
aquatic species , amphiuma tridactylum and necturus
maculosus ; semi - aquatic species , cynops pyrrhogaster ;
terrestria... |
advances in dna sequencing technology are paralleled by advances in network mapping technologies , although network mapping may be more complicated because the biochemical species ( proteins , metabolites , rna and small molecules ) are diverse compared with genome sequencing ( dna only ) .
although knowledge of netw... | a report of the systems biology : networks meeting , cold spring harbor , usa , 22 - 26 march 2011.the success of the human genome project has provided a model for an analogous interactome project to map how proteins , genes , metabolites and other regulatory components interact to transform a biochemical soup into a l... |
ifosfamide is a bifunctional alkylating agent , an oxazaphosphorine derivative with a structural formula similar to that of cyclophosphamide .
it is used as a racemic mixture by intravenous ( iv ) route in the treatment of various tumors .
incidence of ifosfamide - induced central nervous system ( cns ) toxicity oc... | central nervous system ( cns ) toxicity has been reported in approximately 10%30% of patients receiving intravenous infusions of ifosfamide .
encephalopathy is a rare but serious cns adverse reaction in these patients , and although usually transient and reversible , may cause persistent neurological dysfunction or d... |
the past decade has witnessed exponential growth of minimal access surgery ( mas ) in paediatric age group .
virtually every abdominal and thoracic surgery has been performed or attempted using minimal access approach in children .
though the first true neonatal laparoscopy was described in 1973 by gans and berci ... | aims and objectives : the aim of this study was to assess and present the outcome ( initial experience and lessons learnt ) of minimally invasive surgery for various indications in neonates and small infants ( < 5 kg ) at a single medical centre.materials and methods : a retrospective analysis was performed on 65 patie... |
the authors acknowledge support from the army research office ( contract : # w911nf-06-c-0140 ) and the national science foundation ( grant # 0630153 ) . | in this paper , we propose the first numerical study of nanotube - based torsional oscillators via developing a new multiscale model .
the edge - to - edge technique was employed in this multiscale method to couple the molecular model , i.e. , nanotubes , and the continuum model , i.e. , the metal paddle . without lo... |
asian dust ( also yellow sand ) is a dominant springtime aerosol in east asia .
the dust originates from the deserts of east asia , such as the takla makan and gobi , and is spread by prevailing winds not only locally to china and mongolia but also throughout east asia to countries such as korea , taiwan , and japan ... | asian dust is a springtime meteorological phenomenon that originates in the deserts of china and mongolia .
the dust is carried by prevailing winds across east asia where it causes serious health problems .
most of the information available on the impact of asian dust on human health is based on epidemiological inv... |
oral isotretinoin has been in use since 1982 , for severe , nodulocystic acne , refractory to treatment , including oral antibiotics and since 2000 with expanded indication to include acne which causes physical scarring and psychological impact . with this expanded recommendation ,
nearly 1.2 million prescriptions ... | background : the current standard recommendation is to avoid surgical interventions in patients taking oral isotretinoin .
however , this recommendation has been questioned in several recent publications.aim:to document the safety of cosmetic and surgical interventions , among patients receiving or recently received ... |
there are two common ways to evaluate the postural balance of older adults . functional
balance scales , which assess balance through functional tasks , are one type of balance
measure frequently used in clinical and research settings1 . functional balance measures , such as the berg balance scale ( bbs ) ,
have ... | [ purpose ] this study was conducted to assess the reliability and validity of center of
pressure - based parameters for balance assessment .
[ subjects and methods ] two hundred and
forty older adults were evaluated using a force platform and the berg balance scale at
1-week intervals .
the intra - class cor... |
papillary carcinoma is the most prevalent type of thyroid cancer , whereas primary lymphoma of the thyroid gland is distinctly uncommon , accounting for only 0.5% to 5% of all thyroid malignancies and 2% to 7% of all extranodal lymphomas .
as an autoimmune disease , hashimoto thyroiditis ( ht ) is characterized by wi... | papillary thyroid carcinoma ( ptc ) is a common affliction of the thyroid gland , accounting for 70% to 80% of all thyroid cancers , whereas mucosa - associated lymphoid tissue ( malt ) lymphoma of the thyroid gland is uncommon .
the simultaneous occurrence of both malignancies is extremely rare .
we report the cas... |
bacillus species are notable agents of human infectious disease . the spores of b. cereus and b. subtilis are especially known as food contaminants , while b. anthracis is now infamous for its use as a bioterror agent .
b. anthracis was identified in the late 1800s by robert koch as the causative agent of anthrax .
... | effective control of spore - forming bacilli begs suitable physical or chemical methods .
while many spore inactivation techniques have been proven effective , electron beam ( eb ) irradiation has been frequently chosen to eradicate bacillus spores . despite its widespread use , there are limited data evaluating the ... |
majority of the bronchogenic cysts are often asymptomatic and are usually discovered as an incidental finding
. they may become symptomatic due to pressure on the surrounding structures such as trachea and esophagus , as they increase in size or develop infection .
we report the case of a 9-year - old male with a p... | bronchogenic cysts are often asymptomatic and discovered as an incidental finding
. they may become symptomatic due to esophageal compression as they increase in size or from development of infection .
we report a case of a 9-year - old male with an asymptomatic bronchogenic cyst who underwent successful robotic as... |
interferons ( ifn ) are naturally occurring glycoprotein cytokines clinically used as biologic response modifiers .
ifn alpha-2a is a synthetic form of ifn alpha , which is produced by recombinant technology and has been approved by the us fda to treat chronic myelogenous leukaemia , hairy cell leukaemia and aids - r... | the development of biopharmaceutical agents , including the interferons ( ifn ) , offers new treatment options for a wide range of medical conditions .
such advancements , however , have not come without risk to patients .
optic neuropathy in the setting of ifn therapy has been previously documented and is usually ... |
endometrial serous carcinomas , which compromise approximately 10% of endometrial carcinomas , are very clinically aggressive ( clement and young , 2004 ) .
this tumor type constitutes 40% of all deaths and recurrences associated with endometrial cancer ( fader et al . ,
small - cell carcinoma ( scc ) of the endome... | endometrial serous carcinomas are very clinically aggressive , which constitutes 40% of all deaths and recurrences associated with endometrial cancer .
small - cell carcinoma of the endometrium is relatively rare but aggressive , and often presents a component of endometrioid carcinoma , and is not generally associat... |
invasive listeriosis is caused by foodborne transmission of listeria monocytogenes ( lm ) infection , which typically results in septicemia or meningitis among older adults and immunocompromised persons .
intraocular listeriosis is an exceptionally rare manifestation that typically results in profound vision loss [ 2... | intraocular listeriosis , a rare manifestation of invasive listeriosis , has a poor visual prognosis .
we report an intraocular listeriosis case related to a multistate outbreak associated with contaminated cantaloupe
. increasing awareness of rare listeriosis presentations might facilitate timely diagnosis and tre... |
globally , over a million patients are diagnosed with lung cancer each year , making it the most common type of cancer in the world . even though tobacco smoking is considered to be the most common cause of lung cancer ,
it is estimated that 1025% of all patients diagnosed with lung cancer are never smokers .
never... | tobacco smoking is the most common cause of lung cancer , but approximately 1025% of patients with lung cancer are life - long never smokers .
the cause of lung cancer in never smokers is unknown , although tobacco - smoke exposure may play a role in some of these patients .
lung cancer that develops in the absence... |
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