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stress cardiomyopathy ( scmp ) , also known as takotsubo cardiomyopathy or apical ballooning syndrome , is now a well established disease entity and characterized by rapid and severe reversible cardiac dysfunction without significant coronary arterial stenosis.1,2,3 ) emotional or physical stressors have been described... | stress cardiomyopathy ( scmp ) is characterized by a transient left ventricular dysfunction associated with apical ballooning and compensatory hyperkinesias of the basal segments after emotional or physical stress , but inverted or mid - ventricular variants of scmp have also been described .
although catecholamine e... |
5-methylcytosine ( 5mc ) in the dna of mammalian somatic cells is found almost entirely within cpg dinucleotides ( 1 ) .
approximately 7080% of cytosine in cpg dyads is methylated on both strands in human somatic cells . in general , cpg methylation is highly prevalent in repetitive sequences and in gene bodies but r... | cell type - specific dna methylation patterns are established during mammalian development and maintained in adult somatic cells . understanding how these patterns of 5-methylcytosine are established and maintained requires the elucidation of mechanisms for both dna methylation and demethylation .
the enzymes involve... |
aging is a cumulative effect of various deterioration processes , such as oxidation , telomere curtailment , fraying and tearing , and disease - specific processes such as accumulation of bone cell oxidation ( osteoporosis ) or accumulation of blood vessel deposits ( atherosclerosis ) .
however , the exact molecular ... | the association of postmenopausal osteoporosis ( pmop ) with both atherosclerosis and vascular / valvular calcification is well known . recently , ample evidence has suggested a common etiologic factor , namely , reduced hdl - associated paraoxonase 1 ( pon1 ) activity , as a causative factor in the development of pmop... |
eighty - nine subjects with type 1 diabetes were accrued from the endocrinology and neurology clinics at the toronto general hospital / university health network .
an additional 60 healthy volunteers were recruited by community advertisement and sampling among family and friends of diabetic subjects .
volunteers we... | objectivereduced heart rate variability ( hrv ) is classically viewed as an early phenomenon in diabetic sensorimotor polyneuropathy ( dsp ) .
we aimed to determine the characteristics of hrv across the spectrum of clinical dsp in type 1 diabetes.research design and methodseighty - nine diabetic subjects and 60 healt... |
i begin with my own experiences in working with a nontraditional model fungus called ashbya gossypii . as a postdoc in peter philippsen
s group in unibasel , switzerland , i started work with ashbya , which is relatively closely related on the genome scale to the budding yeast saccharomyces cerevisiae but has some st... | in this essay i would like to highlight how work in nontraditional model systems is an imperative for our society to prepare for problems we do not even know exist .
i present examples of how discovery in nontraditional systems has been critical for fundamental advancement in cell biology .
i also discuss how as a ... |
diabetes mellitus continues to be a tremendous burden throughout the world and is a significant cause of morbidity and mortality .
diabetic retinal neovascularization is considered to be a major consequence of retinal ischemia caused by capillary occlusion , and the mechanism of its development is not clear [ 2 , 3 ]... | the aim of the study was to assess serum fibroblast growth factor 21 ( fgf21 ) concentrations in chinese type 2 diabetic patients with and without retinopathy and to assess the association between fgf21 and the severity of retinopathy .
117 diabetic patients were compared with 68 healthy controls . fasting blood gluc... |
micro ( mi)rnas form a class of short rnas ( ~21 nt ) that post - transcriptionally regulate partially complementary messenger ( m)rnas .
each mirna may target tens - to - hundreds of transcripts to control key biological processes . while the biochemical reactions underpinning mirna biogenesis and activity are relat... | |
colon cancer is one of the most common causes of cancer deaths worldwide . in recent years
, new regimens for colon cancer combining chemotherapy and biological agents have improved the overall survival and progression - free survival ( pfs ) .
one of them , the combination of bevacizumab and capecitabine plus irin... | it has been reported that many patients with lung metastasis of colorectal cancer ( crc ) underwent chemotherapy with fluorouracil , folinic acid , oxaliplatin , irinotecan , or capecitabine .
there is a small number of reports about the capecitabine and irinotecan ( xeliri ) plus bevacizumab ( bv ) therapy for patie... |
several hormonal changes are produced during pregnancy that can increasingly predispose to infections of the lower genital tract [ 14 ] .
these infections are associated with a great number of gynecologic and obstetric complications , such as preterm birth [ 513 ] , premature rupture of the membranes [ 1416 ] , chori... | objective . to assess the vaginal inflammatory status ( vis ) in pregnant women , whether symptomatic or asymptomatic , by leukocyte quantification in relation to the microbiota during each pregnancy trimester ( t ) .
materials and methods . a thousand two hundred and forty eight vaginal exudates from pregnant wome... |
today b - mode is routinely used in clinical practice for the diagnosis of congenital heart disease and to plan surgical procedures.1 two - dimensional echocardiography visualizes the anatomy of the heart in two - dimensional spatial images displayed in real - time , moving pictures .
the examiner as well as the view... | three - dimensional echocardiography is increasingly available .
we report our experience with 3d reconstructions of ventricular septal defects : unique images of all different types of ventricular septal defects are reconstructed from left and right ventricular en - face views .
the images are discussed according ... |
investigators at niguarda cancer centers are supported by the following grants : terapia molecolare dei tumori ( ss and asb ) from fondazione oncologia niguarda onlus ; associazione italiana per la ricerca sul cancro ( airc ) 2010 special program molecular clinical oncology 5x1000 , project 9970 ( ss and ab ) ;
| in metastatic colorectal cancer ( crc ) , actionable genetic lesions represent potential clinical opportunities .
ntrk1 , 2 , and 3 gene rearrangements encode oncogenic fusions of the tropomyosin - receptor kinase ( trk ) family of receptor tyrosine kinases in different tumor types .
the tpm3-ntrk1 rearrangement is... |
domestic violence is a pattern of threatening behaviour , violence , or abuse including psychological , physical , sexual , financial , or emotional abuse between adults in the same family or who are or have been intimate partners .
it is a severe breach of human rights with profound consequences , particularly for w... | the perceptions and experiences among general practitioners ( gps ) and nurses in identifying female patients experiencing domestic violence and referring patients to specialist agencies need to be clarified .
eleven gps and six nurses participating in a multidisciplinary domestic violence training and support progra... |
facial attractiveness including dental and smile esthetics not only impacts social interactions , but also exerts a significant influence on self - concept , psychological well - being and social behavior .
attractive individuals are more successful at school , in job interviews and even in mate selection [ 25 ] . or... | objectives : this study aimed to find the factors that affect dental esthetics and smile attractiveness in orthodontically treated patients according to laypeople s judgment , and to determine whether there is any relationship between dental and smile esthetics.materials and methods : using the q - sort technique , 60 ... |
the liver is an organ that performs considerable metabolic functions regarding the activity of other organ systems .
this regeneration , in turn , will last until the liver regains its original mass .
leptin is a member of the super family of cytokines and influences body weight and homeostasis through effects on f... | backgroundthe aim of this study was to evaluate the potential effect of intraperitoneal administration of leptin on the hepatic regeneration and the mitotic index.material/methods56 sprague - dawley rats were divided into 7 groups each containing 8 rats .
group 1 was evaluated as the sham group and no surgical proced... |
patients with end - stage renal disease ( esrd ) have a high incidence of tuberculosis .
isoniazid ( inh ) is an anti - tuberculosis drug with well - known neurological side effects including encephalopathy . in this report
, we present two cases of inh - induced encephalopathy in patients with esrd who received an... | we report isoniazid ( inh)-induced encephalopathy in two male patients on hemodialysis .
one of them had tuberculous adenitis , and the other had pulmonary tuberculosis .
both were given rifampicin , inh , pyrazinamide , and ethambutol with pyridoxine 40 mg / day .
two patients developed disturbances in conscious... |
pancreatic pseudocysts are a collection of pancreatic secretions enclosed in fibrous tissue layer without a lining of epithelium and are usually located in the peripancreatic region.1 they may also rarely occur at unexpected and atypical locations such as the spleen , liver , mediastinum , pelvis and kidney depending u... | background : intramural pseudocysts or pseudocysts occurring in the gastrointestinal tract ( git ) wall are rare and there is a paucity of data on their clinical features and management.patients and methods : we retrospectively evaluated patients with intramural pseudocysts seen at our institution over the past 6 years... |
breast cancer is the most common cancer of women in the world over , and its incidence is rising , especially in developing countries , where the disease poses a major health care challenge .
this growing incidence in developing countries reflects the advanced stage at diagnosis , low levels of public awareness of th... | objectives : this study was conducted to determine breast cancer survival time and the association between breast cancer survival and socio - demographic and pathologic factors among women , in el - minia , egypt .
while there has been much researches regarding prognostic factors for breast cancer but the majority of... |
phylogenetic analysis in biological macromolecule sequences is an important and common strategy for research into evolution and taxonomy .
one major advantage of the proposed approach is that it estimates evolutionary distance using genetic information instead of traditional , standard morphological measurements ( 1,... | power , the phylogenetic web repeater , is a web - based service designed to perform user - friendly pipeline phylogenetic analysis .
power uses an open - source lamp structure and infers genetic distances and phylogenetic relationships using well - established algorithms ( clustalw and phylip ) .
power incorporate... |
accurate modeling of the 3d structure of a complex assists in understanding its function in the cell .
additionally , atomic structures of molecular complexes are used in the field of drug design , permitting the design of small molecules that prevent or induce the formation of certain complexes . in some cases , the... | protein protein docking algorithms aim to predict the structure of a complex given the atomic structures of the proteins that assemble it .
the docking procedure usually consists of two main steps : docking candidate generation and their refinement .
the refinement stage aims to improve the accuracy of the candida... |
in 95% of cases of acute cholecystitis the cause is a gallstone blocking the cystic duct subsequently leading to inflammation of the gallbladder by chemicals or bacteria ( 1 ) .
the localised peritonitis that ensues means patients characteristically present with a history of severe , sudden onset , constant or colick... | cystic artery pseudoaneurysm ( cap ) is a very rare complication of acute cholecystitis .
we present the unruptured cystic artery pseudoaneurysm of an oedematous , thick - walled gallbladder in a 71-year old gentleman admitted with acute calculus cholecystitis .
this was managed by radiological microcoil embolisati... |
stroke patients generally suffer from significant impairments , including muscle weakness ,
loss of motor control , and spasticity1,2,3,4 . in rehabilitation
, it is important to
understand nerve and cardiovascular system impairment because this type of subtle disorder
might be closely related to functional out... | [ purpose ] brachial - ankle pulse wave velocity ( bapwv ) , which has been reported as an
index of arterial stiffness , is very closely related to cardiovascular risk factors .
a
high bapwv indicates high cardiovascular risk .
however , bapwv and pressure waveforms after
stroke are not fully understood .
[... |
the most common renal lesions associated with the human immunodeficiency virus ( hiv ) are collapsing focal segmental glomerulosclerosis ( fsgs ) and hiv - associated nephropathy .
lupus - like glomerulonephritis is a type of immune complex - induced renal injury seen rarely in hiv patients which is characterized by ... | immune complex
lupus - like glomerulonephritis is a type of renal injury seen infrequently in human immunodeficiency virus ( hiv ) patients and very little is known about the clinical course and treatment .
treatment options are limited but antiretroviral therapy and steroids have been tried with limited success . ... |
multidimensional factors in the etiology of childhood malnutrition are intrauterine growth retardation , lack of exclusive breast feeding , inappropriate complementary feeding , repeated attacks of infectious illnesses , inadequate food intake , and micronutrient deficiencies .
inadequate food intake may be diet scar... | objective : cyproheptadine hydrochloride ( ch ) is a first - generation antihistamine which is used as an appetite stimulant .
this study was designed to identify the role of ch therapy on weight gain , linear growth and body mass index in children with mild to moderate undernutrition.methods:eighty-nine patients wer... |
alzheimer 's disease ( ad ) is the most common form of dementia in elderly people .
estimates suggest that 10% of individuals over the age of 65 and almost half over the age of 85 have alzheimer 's dementia . as human life expectancy continues to rise , the total number of affected individuals is also expected to inc... | backgroundapolipoprotein a1 ( apoa1 ) is the major apolipoprotein constituent of the high - density lipoprotein ( hdl ) and is involved in reverse cholesterol transport .
variation in the apoa1 gene might influence the function of the protein and , thus , brain cholesterol metabolism , leading to an increased risk fo... |
cocaine abuse has been associated with multiple known adverse effects , including myocardial ischemia , cerebrovascular accidents , pulmonary edema , and mesenteric ischemia . however , the effects of cocaine on other organs have not been extensively reported .
we present a middle age patient who developed multi orga... | cocaine has been associated with known adverse effects on cardiac , cerebrovascular and pulmonary systems . however , the effect of cocaine on other organs has not been extensively reported . a middle age man presented with abdominal pain and nausea after inhalation of crack cocaine . on admission , he was found to be ... |
three cancers are especially prevalent in human immunodeficiency virus ( hiv)-positive individuals and are considered acquired immunodeficiency syndrome ( aids ) defining illnesses : kaposi sarcoma , high - grade b - cell non - hodgkin lymphoma , and invasive cervical carcinoma .
several studies have evaluated the ro... | fluorodeoxyglucose - positron emission tomography / computed tomography ( fdg pet / ct ) has proven useful in the diagnosis , staging , and detection of metastasis and posttreatment monitoring of several malignancies in human immunodeficiency virus ( hiv)-infected patients . it also has the ability to make the importan... |
distal triceps tendon rupture is an uncommon lesion rarely due to a non - traumatic mechanism . in these cases ,
the majority of patients show predisposing factors for tendon degeneration : underlying medical co - morbidities , previous systemic and locally injected corticosteroids and systemic anabolic steroids . a ... | introduction : distal triceps tendon rupture is an uncommon lesion rarely due to a non - traumatic mechanism . in these cases , the majority of patients show predisposing factors for tendon degeneration : underlying medical co - morbidities , previous systemic and locally injected corticosteroids and systemic anabolic ... |
visualization of the spinal cord in zebrafish is inhibited by a number of factors . due to the thickness of the overlying
somites and the internal location of the spinal cord , a considerably long working distance is required for high cellular resolution . the yolk ball ( which is still present during early stages o... | the zebrafish spinal cord is an effective investigative model for nervous system research for several reasons .
first , genetic , transgenic and gene knockdown approaches can be utilized to examine the molecular mechanisms underlying nervous system development .
second , large clutches of developmentally synchroniz... |
cataract surgery in highly myopic patients poses certain challenges , and is also prone to postoperative complications such as posterior capsule wrinkling , posterior capsule opacification ( pco ) , and retinal detachment , all of which require special techniques and solutions to minimize their frequency . there have b... | backgroundthe aim f this study was to evaluate the effect of capsular tension ring implantation during cataract surgery on the incidence of neodymium : yag ( nd : yag ) laser posterior capsulotomy in myopic ( axial length [ al ] 25.00 mm ) eyes.material/methodsin this retrospective study , the records of the cases of 1... |
trauma mortality has been described to have a trimodal or bimodal distribution [ 1 - 4 ] . of trauma deaths
there is then a second peak , which represents 30% of the deaths that occur early , half of which are due to uncontrollable hemorrhage . a third phase of later deaths , related to multiple organ failure ( mof )... | in this article we describe the current use of recombinant activated factor vii ( rfviia ; novoseven ) in trauma patients . emphasis is placed on current uses as defined by key studies , efficacy data , and safety data .
most published studies in trauma patients are retrospective case studies and reports , although a... |
childhood - onset schizophrenia ( cos ) describes an individual meeting the adult dsm criteria for schizophrenia , but with onset of psychosis before the age of 13 13 .
childhood - onset schizophrenia is rare , comprising less than 1% of all schizophrenia cases 1,2,4,5 .
compared to adult - onset schizophrenia , wh... | key clinical messagechildhood - onset schizophrenia is rare , comprising 1% of known schizophrenia cases . here , we report a patient with childhood - onset schizophrenia who has three large chromosomal abnormalities : an inherited 2.2 mb deletion of chromosome 3p12.2p12.1 , a de novo 16.7 mb duplication of 16q22.324... |
despite the reported benefit of therapeutic hypothermia ( th ) , its practice in the critical care world remains limited especially in developing countries unlike the western world where it is an established intervention following cardio - pulmonary resuscitation ( cpr ) .
asian countries including middle east and in... | poor neurological outcome is a common sequel of prolonged cardiac arrest .
although therapeutic hypothermia ( th ) for neuroprotection has been a subject for research for over half a century , its use has been limited because of many controversies and lack of clear guidelines .
however for over two decades there ha... |
malignant peripheral nerve sheath tumours ( mpnsts ) have an incidence of 1 per 1,000,000 people per year ( 1 ) and comprise around 3% of soft - tissue sarcomas ( 2 ) .
tumours arise from schwann cells or perineural cells that ensheath axons and extend along neural tracts .
they are aggressive cancers that have hig... | we present the case of a malignant peripheral nerve sheath tumour ( mpnst ) that developed on the upper lip of an 86 year old woman .
mpnsts are highly aggressive sarcomas that very rarely occur in the face .
we know of no other reported cases of a malignant peripheral nerve sheath tumour arising from the upper lip... |
the world health organization ( who ) reported recently a significant decline in the global malaria burden over the last 15 years , achieving the 2000 millennium development goals .
fifty - seven countries have reduced their malaria cases by 75% , in line with the world health assembly 's target for 2015 .
malaria ... | introduction .
the characterization of genetic profile of plasmodium isolates from different areas could help in better strategies for malaria elimination . this study aimed to compare p. falciparum diversity in two african countries
. methods .
isolates collected from 100 and 73 falciparum malaria infections in ... |
esophageal cancer is the eighth most common cancer and the sixth most common cause of cancer deaths worldwide .
esophageal squamous cell carcinoma ( escc ) is the major histopathological subtype of esophageal cancer .
unfortunately , systemic radiotherapy alone is ineffective in patients with unresectable , recurre... | backgroundradiotherapy is one of the primary treatments for esophageal squamous cell carcinoma ( escc ) .
identification of novel radio - sensitizing agents will improve the therapeutic outcome of radiotherapy .
this study aimed to determine the radio - sensitizing effect of the antipsychotic agent thioridazine in ... |
during the winter months of 2014 a 47-year - old man was found unconscious by his family at his home in victoria , australia . he had a 2-day history of upper respiratory tract symptoms ( cough , dyspnea , rhinorrhea , myalgia , and headache ) .
emergency services personnel determined he had a glasgow coma scale scor... | human metapneumovirus pneumonia , most commonly found in children , was diagnosed in an adult with encephalitis .
this case suggests that testing for human metapneumovirus rna in nasopharyngeal aspirate and cerebrospinal fluid samples should be considered in adults with encephalitis who have a preceding respiratory i... |
peter takes pleasure , maybe somewhat perversely , in standing thigh - high in slow - flowing water , principally cold mountain lakes and rivers .
garbed in heavy waders and water - proofs against the weather , he monitors the health of fresh - water fish , concerned with the effects of the wash - off of organo - pho... | abstractearly years science education is not science , but a curricular construction designed to induct young children into a range of ideas and practices related to the natural world . while inquiry - based learning is an important approach to this , it is not of itself unique to science and there are a range of logic... |
sleep disorders have been linked to a number of generalized health and behavioral disorders , including reduced efficiency while operating a motor vehicle . in recent years
, a number of studies have shown consistent linkages between lack of sleep , circadian rhythm disorders ( crsds ) , and fatigue , on the one hand... | studies have shown that a large proportion of traffic accidents around the world are related to inadequate or disordered sleep .
recent surveys have linked driver fatigue to 16% to 20% of serious highway accidents in the uk , australia , and brazil .
fatigue as a result of sleep disorders ( especially obstructive s... |
oral bacteria cause many infectious diseases such as dental caries , periodontal disease , and endodontic infections .
it has also been demonstrated that oral bacteria are involved in various systemic diseases such as endocardial inflammation , aspiration pneumonitis , and diabetes , and controlling these bacteria is... | safe and effective methods for oral bacterial disinfection have been desired , since bacteria cause many infectious diseases such as dental caries , periodontal disease , and endodontic infections .
singlet oxygen ( 1o2 ) is attractive , because it is toxic to prokaryotic cells , but not to eukaryotic cells .
we se... |
repeated inflammation and the resulting increased proliferation ( mitotic activity ) of tissue cells are correlated with the development of carcinoma , presumably by chromosomal instability , an increased rate of random mutations [ 1 , 2 ] , and promotion of tumor growth [ 3 , 4 ] .
there are many reported clinical i... | nowadays , patients with chronic hepatitis c in all countries are generally treated with interferon ( ifn ) , and more than 50% of patients become hcv - rna negative following peg - ifn plus ribavirin therapy , but unfortunately , the ifn therapy is not effective in about 70% of patients with hcv - associated lc . in j... |
non - obstructive azoospermia ( noa ) is generally considered a non - medically manageable cause of male infertility .
these patients , who constitute up to 10% of all infertile men , have abnormal spermatogenesis as the cause of their azoospermia .
the establishment of in vitro fertilization using intracytoplasmic... | non - obstructive azoospermia is diagnosed in approximately 10% of infertile men .
it represents a failure of spermatogenesis within the testis and , from a management standpoint , is due to either a lack of appropriate stimulation by gonadotropins or an intrinsic testicular impairment .
the former category of pati... |
in the neck , various vital structures , such as blood vessels , respiratory organs , and parts of the digestive system , nervous system , and endocrine system , are present in a narrow space .
a penetrating trauma occurring in the neck can cause severe complications such as hemorrhage as the result of vascular injur... | penetrating neck injuries are potentially dangerous and require emergent management because of the presence of vital structures in the neck . penetrating vascular trauma to zone i and iii of the neck is potentially life - threatening .
an accurate diagnosis and adequate surgical intervention are critical to the succe... |
a 68-year - old woman was referred to the department of otorhinolaryngology , head and neck surgery because of speech and swallowing problems following a circumferential pharyngolaryngectomy with free jejunal repair because of an extended papillary thyroid carcinoma ( pt4n0m0 ) .
postoperatively , the patient was tre... | the case of a 68-year - old woman with postoperative speech and swallowing problems following a circumferential pharyngolaryngectomy and neopharyngeal reconstruction with a jejunal free flap is presented .
the primary tumor was an extended papillary thyroid carcinoma ( pt4n0m0 ) .
for vocal restoration , an indwell... |
aria guideline defines rhinitis as a chronic inflammatory disease of the nose resulting in nasal symptoms including nasal obstruction , sneezing , and anterior or posterior rhinorrhea ( occurring during two or more consecutive days for more than one hour ) .
allergic rhinitis ( ar ) is the most common form of noninfe... | chronic rhinitis and rhinosinusitis ( crs ) are relevant health conditions affecting significant percentages of the western population .
they are frequently coexisting and aggravating diseases . both are chronic , noninfectious , and inflammatory conditions sharing to a certain extent important pathophysiologic simil... |
because slightly different sets were used in different phenotyping experiments , the total number of lines used was 199 ( supplementary table 1 ) .
genotyping was done using standard protocols , and a combination of snp calling and imputation algorithms were used to analyze the results ( see supplementary section 1 )... | although pioneered by human geneticists as a potential solution to the challenging problem of finding the genetic basis of common human diseases1,2 , advances in genotyping and sequencing technology have made genome - wide association ( gwa ) studies an obvious general approach for studying the genetics of natural vari... |
myxomas are the most common type of primary cardiac tumors , representing 30 - 50% of all cardiac tumors.1 ) typically , myxomas manifest as a solitary , pedunculated , mobile mass in the left atrium ( la ) with a stalk that is attached to the interatrial septum .
however , the echocardiographic diagnosis of myxomas ... | echocardiographic diagnosis of atrial myxoma may not always be straightforward , and the distinction between myxoma and thrombi is not easy , especially when we observe a mass after successful surgery .
our report describes a 72-year - old woman who presented with right upper limb hemiparesis and was subsequently dia... |
the most common lesions of venous malformations in the
head and neck region are internal jugular vein aneurysms and phlebectasias .
although these terms are frequently used as synonyms , they pertain to two
divergent conditions , likely of different etiology and pathophysiology .
macroscopically , aneurysms are... | venous malformations of the jugular veins are rare findings .
aneurysms and phlebectasias are the lesions most often reported .
we report on an adult patient with an abruptly appearing large tumorous mass on the left side of the neck identified as a jugular vein aneurysm . upon clinical examination with ultrasound ... |
cardiofacio - cutaneous ( cfc ) syndrome ( omim : 115150 ) is a rare , sporadic , heterogeneous disorder first described by reynolds et al . in 1986 .
cfc syndrome is characterized by multiple congenital anomalies consisting of peculiar craniofacial dysmorphism , congenital heart defects , ectodermal anomalies , and ... | cardiofacio - cutaneous syndrome is a rare genodermatoses with multiple congenital anomalies ( mca ) and mental retardation .
although various mutations have been described , the diagnosis can be made clinically based on constellation of symptoms .
herein , we report a classical case with typical craniofacial featu... |
azacitidine ( 5-azacitidine ) is an analogue of the naturally occurring pyrimidine nucleoside cytidine possessing pharmacological effects on cell differentiation , gene expression , and dna synthesis and metabolism [ 14 ] .
mechanistically , azacitidine is believed to exert its antineoplastic effects by causing hypom... | purposeto assess the potential inhibitory and inductive effects of azacitidine on cytochrome p450 isozymes in vitro.methodsthe inhibitory effects of azacitidine on various cyp isozymes were determined in human liver microsomes .
in addition , the ability of azacitidine to induce cyp enzymes in cultured human hepatocy... |
recognizing that the reimbursement methodology for medicare inpatient care was contributing to the rapidly escalating national medical care expenditures , congress enacted public law 98 - 21 in april 1983 .
the act provided for an entirely different reimbursement methodology , one that completely discarded the retroa... | children 's hospitals were excluded indefinitely from the prospective payment system until a methodology for their reimbursement could be developed .
special consideration in reimbursement policy could be made for children 's hospitals if their patients were generally more resource intensive than the pediatric patien... |
-diversity comparison of mock community reads filtered using select quality parameter settings ( dataset 1 ) . family - level taxon counts ( z - axis ) for mock communities filtered with variable split_library_fastq.py parameters , showing all cross - interactions between minimum per - read length as % of total read le... | high - throughput sequencing has revolutionized microbial ecology , but read quality remains a significant barrier to accurate taxonomy assignment and alpha diversity assessment for microbial communities . we demonstrate that high - quality read length and abundance are the primary factors differentiating correct from ... |
dacryoadenitis is a rare disorder that is caused by an obstruction occurring anywhere between the conjunctiva and the lacrimal ductules .
if improperly treated , dacryoadenitis can result in orbital abscess or cellulitis . as a result
, patients should be monitored very closely and iv antibiotics should be administ... | acute dacryoadenitis is an uncommon condition that involves inflammation of the lacrimal gland . in rare instances , dacryoadenitis may be bilateral .
a delay in proper treatment of an otherwise simple case of dacryoadenitis may lead to significant soft tissue morbidity such as cellulitis , lacrimal gland abscess , o... |
summary of three patients was shown in table 1 . detailed angiographic findings were compared in table 2 . a 53-year - old healthy female patient developed an acute onset of severe occipital headache .
computed tomography ( ct ) scans showed a subarachnoid hemorrhage ( sah ) mainly around the brainstem .
cerebral a... | formation of de novo aneurysm from a junctional dilatation at the origin site of the posterior communicating artery ( pcoma ) has been rarely reported . in this case report
, three females in sixth decades of age developed a de novo aneurysm from the junctional dilatation of the pcoma with a tiny bleb - like lesion o... |
there are 52,715 bachelor of medicine and bachelor of surgery ( mbbs ) seats across 412 medical colleges in india . and , more than 10 times are the numbers of applicants eyeing for entry to this coveted field .
there is usually a selection bias such that those who are intelligent have high levels of personal drive a... | background : medical students can and do suffer from mental disorders is a concept yet to get wide acceptance .
there are few studies comprehensively evaluating depression , stress , and burnout in medical students , especially in a longitudinal way in india .
the current study aims to assess the impact of medical ... |
the principal theory of laser refractive surgery is that the optical power of the eye can be changed by modifying the corneal curvature .
laser in situ keratomileusis ( lasik ) is performed to correct myopia and myopic astigmatism by ablating the corneal tissue and flattening the central anterior corneal curvature . ... | purpose . to evaluate the effect of preoperative and postoperative keratometry on the refractive outcome after laser in situ keratomileusis ( lasik ) for moderate and high myopia
. methods .
records of 812 eyes ( 420 patients ) with myopia 6 d who had lasik at sohag laser center , egypt , from january 2010 to nove... |
cryptococcus neoformans is a yeast - like encapsulated fungus , which is mainly found in the droppings of pigeons .
the inhalation of contaminated dust is the major infectious pathway , which can result in pulmonary involvement and may spread to other organs such as the cns and skin .
cryptococcal infections occur ... | we report the case of a 68-year - old woman with autoimmune hepatitis ( aih ) who had leg ulcers induced by disseminated cryptococcosis .
she had received prednisolone for her aih at 20 mg / day for maintenance . on the initial visit
, she complained of a painful ulcer that had round , shallow pockets with erythema... |
renal biopsy interpretation requires histological examination by light microscopy , direct immunofluorescence ( dif)/immunohistochemistry , and electron microscopy .
dif is simple , fast and very sensitive technique in which fluorescent tagged monoclonal antibodies are used for staining on frozen kidney biopsies sect... | renal biopsy interpretation requires histopathology , direct immunofluorescence ( dif ) and electron microscopy .
formalin - fixed , paraffin - embedded tissue ( ffpe ) sent for light microscopy can be used for dif after antigen retrieval
. however , complement staining has not been satisfactory .
we standardized... |
for benign diseases of the gall bladder ( gb ) , laparoscopic cholecystectomy has been established as the gold standard and is preferred over open cholecystectomy . as patient demand has increased for improved postoperative quality of life and cosmesis , surgeons have continued to decrease the number of ports for lapar... | background and objectives : single - port laparoscopic cholecystectomy ( splc ) was introduced to improve patients ' postoperative quality of life and cosmesis over the conventional approach ( clc ) .
the purpose of this case control study was to compare the outcome of splc with that of clc in a specific disease : g... |
renal cell carcinoma ( rcc ) accounts for approximately 2% of all adult malignancies and represents the third most common tumor of genitourinary tract affecting 115,200 new cases and 49,000 deaths in europe .
rcc behavior is variable ; up to 20% of cases may have periods of slow tumor growth or stability lasting many... | highlightsrcc is the predominant primary tumor for isolated pancreatic metastases.pancreatic metastases from rcc generally tends to slow growth and indolent behavior.surgical resection may be curative and should be considered in selected patients.it is still controversial whether to perform typical or atypical surgical... |
a number of stressors
have been implicated in honeybee losses in
many parts of the world , including habitat
loss ; viral diseases ; parasites such as varroa destructor , which can be a disease vector ; and use of pesticides . because these stressors may interact , it is difficult
to predict how they change the... | to simulate effects of pesticides
on different honeybee ( apis mellifera l. ) life stages , we used the beehave
model to explore how increased mortalities of larvae , in - hive workers ,
and foragers , as well as reduced egg - laying rate , could impact colony
dynamics over multiple years .
stresses were appl... |
urogenital infections ( ugis ) are prevalent during pregnancy and are recognized as an important cause of premature labor .
normal cervicovaginal flora plays a crucial role in the defense against the growth and ascension of pathogens .
lactobacilli exercises a local defense mechanism due to its production of lactic... | urogenital infections are extremely prevalent during pregnancy and are an important cause of premature labor . however , the prevalence of urogenital infections during childbirth is not well known . objective .
identify urogenital infections present at the beginning of labor in both full - term and preterm pregnancie... |
recently the mean age at menopause is over 45 years in 88% of women , under 45 years in 9.7% , and under 40 years in only 1.9%.1 there have been some researches about premature ovarian failure ( pof ) , hormone and chromosome.234 the loss of functional follicles occurring in women under the age of 40 is defined as pof.... | premature ovarian failure ( pof ) is a condition in which the ovarian functions of hormone production and oocyte development become impaired before the typical age for menopause .
pof and early menopause are present in a broad spectrum of gonad dysgenesis , from a complete cessation of ovarian function to an intermit... |
swim s 77 medium , fetal bovine serum , calf serum , horse serum , and wortmannin were obtained from sigma - aldrich , ( st louis , mo ) .
rnase h , and proteinase k were purchased from gibco / brl ( bethesda , md ) .
rnasin was obtained from promega ( madison , wi ) , dnase i and rnase t1 from worthington / cappel... | insulin regulates a large number of genes in a tissue - specific manner .
we have previously identified genes modulated by insulin in the liver and in liver - derived cells that have not yet been characterized as insulin regulated , and results of these previous studies indicated that numerous genes are induced by in... |
osteoporosis is characterized by the depletion of bone mineral mass , combined with bone micro - architecture deterioration , greater bone fragility and a resultant increased fracture risk ; a 10% loss of vertebral bone mass can double the risk of a vertebral fracture .
osteoporosis is one of the most prevalent skele... | osteoporosis is one of the most prevalent skeletal disorders and has enormous public health consequences due to the morbidity and mortality of the resulting fractures .
this article discusses the developmental origins of osteoporosis and outlines some of the modifiable and non - modifiable risk factors in both intrau... |
multiple endocrine neoplasia type 2 ( men2 ) is a rare autosomal dominant inherited disorder with a high lifetime risk of medullary thyroid carcinoma ( mtc ) [ 1 , 2 ] .
men2 consists of three syndromes : familial medullary thyroid carcinoma ( fmtc ) , men2a , and men2b [ 1 , 3 ] .
men2a families have mtc , with at... | multisample , nonindexed pooling combined with next - generation sequencing ( ngs ) was used to discover ret proto - oncogene sequence variation within a cohort known to be unaffected by multiple endocrine neoplasia type 2 ( men2 ) .
dna samples ( 113 caucasians , 23 persons of other ethnicities ) were amplified for ... |
schizophrenia is a severe , chronic , and debilitating neuropsychiatric disorder that involves a profound psychopathology disruption of cognition , emotion , perception , and other aspects of behavior .
it is an illness that compromises the effective functioning of the individual in social , occupational , and daily ... | patients with psychiatric problems show a tendency to develop temporomandibular disorders ( tmd ) .
particularly , patients with schizophrenia are quite likely to have signs and symptoms of tmd due to the impairment of their oral health , the use of antipsychotic drugs , and other general health problems . in nonschi... |
esophageal leiomyoma , although rare , is the most common benign mesenchymal tumor of the esophagus : it accounts for 60% to 70% of all benign esophageal tumors.12 the incidence of esophageal leiomyoma in autopsy cases ranges from 0.005% to 5%.3 it usually appears as a solitary tumor ( 97% ) , and multiple leiomyomas o... | the coexistence of an epithelial lesion and a subepithelial lesion is uncommon . in almost all such cases , the coexistence of these lesions appears to be incidental .
it is also extremely rare to encounter a neoplasm in the surface epithelium that overlies a benign mesenchymal tumor in the esophagus .
several case... |
despite the decreased prevalence of dental caries in the recent years , it is still a common chronic disease of the childhood .
it primarily affects the cervical third of the maxillary incisors and then the primary first molars . due to
the small size of crown of incisor teeth , progression of caries causes extensi... | objectives : this study sought to compare the push - out bond strength of two bulk - fill and one conventional composite to intracanal dentin in primary anterior teeth.materials and methods : this in vitro , experimental study was conducted on 39 primary anterior teeth , which were randomly divided into three groups . ... |
obstructive jaundice is commonly caused by a stone or growth in common bile duct ( cbd ) .
foreign bodies in the biliary tract like sutures,1 fish bone,2 tomato skin,3 surgical gauze,1,4,5 and chicken bone6 represent an uncommon clinical entity and are rare cause of biliary obstruction.1,4 however with recent advance... | biliary obstructions are rarely caused by a foreign body and have received sparse attention .
we present an unusual case with pruritis and abdominal pain caused by impacted full length surgical gauze within the common bile duct .
the patient had previously undergone an open cholecystectomy .
radiological investig... |
an estimated 50% of pregnancies with maternal syphilis will end in fetal or perinatal death , low birth weight babies , or babies born with congenital syphilis .
necrotizing funisitis , which is associated with increased rates of stillbirth , perinatal infection , and preterm delivery , is sometimes accompanied with ... | syphilis remains a serious cause of neonatal morbidity and mortality worldwide . in this paper , we describe a case of congenital syphilis that was fully supported by abnormal fetal heart rate patterns and placental histopathological evidence . a 24-year - old para 4 woman , who did not attend antenatal care ,
was ad... |
they are also marker of the atherosclerotic burden of the individual especially the descending aorta . the calcific great vessels , on losing the elastic property place a high afterload on the heart accentuating heart failure .
management of these calcific aortas is a controversy and revascularisation of the calcific... | calcific aorta is a disease of old age and is an independent risk factor for morbidity and mortality . here
, we present two patients with calcific aorta at different levels .
one with a descending porcelain aorta , and modified bentall 's procedure was done .
second is a patient who is having a calcific ascendin... |
multiple sclerosis ( ms ) is a chronic disease of the central nervous system with symptoms that impact health - related quality of life ( hrqol ) [ 1 , 2 ] .
the extent to which the menopausal transition in women worsens ms symptoms remains largely unexplored .
previous studies have addressed symptom management in ... | background . in multiple sclerosis
( ms ) , symptom management and improved health - related quality of life ( hrqol ) may be modified by smoking . objective . to evaluate the extent to which smoking is associated with worsened health outcomes and hrqol for postmenopausal women with ms .
methods .
we identified 2... |
ala - al - din abu al - hassan ali ibn abi - hazm al - qarshi al - dimashqi , known as ibn al - nafis ( 1210 - 1288 ad ) , was a muslim syrian physician primarily famous for being the first to describe the pulmonary circulation of the blood .
the most voluminous of his books is alshamel fi sanaat tebbiat , which is a... | background : ala - al - din abu al - hassan ali ibn abi - hazm al - qarshi al - dimashqi , known as ibn al - nafis ( 1210 - 1288 ad ) , was a muslim syrian physician primarily famous for being the first to describe the pulmonary circulation of the blood .
the most voluminous of his books is alshamel fi sanaat tebbiat... |
it is believed that the gingival epithelial cells play an active role in host defenses by responding to bacteria in an interactive manner . among the immune cells , intraepithelial lymphocytes together with immunocompetent langerhans cells ( lcs )
the lcs are a type of antigen presenting cells and their function is t... | background : the langerhans cells ( lcs ) are dendritic cells ( dcs ) which belong to the group of antigen presenting cells ( apcs ) . their function is to recognize the antigen , capture it , and present it to the t lymphocytes ; thus initiating an early immune response .
the antigen presenting functional lcs may pl... |
helping patients regain the ability to walk is one of the primary objectives of
rehabilitation facilities , such as those in hospitals and nursing homes , during both the
acute and recovery stages of stroke .
walking environments vary tremendously , however , and
patients must learn to cope with many different ... | [ purpose ] the purpose of this study was to clarify the difference in gait parameters of
at - home walking and the 10-meter walking test results of individuals with hemiparesis .
[ subjects ] a total of 14 hemiparetic stroke recovery patients participated in this study .
inclusion criteria were : living at home ... |
this study analyzed data from the ncdr icd registry , the details of which have been previously published . in brief , this registry was established in 2005 in concert with the centers for medicare and medicaid services expansion of coverage for primary prevention icd implantation , with the goal of prospectively enrol... | background older recipients of implantable cardioverter - defibrillators ( icds ) are at increased risk for short - term mortality in comparison with younger patients . although hospice use is common among decedents aged > 65 , its use among older icd recipients is unknown.methods and results medicare patients aged >... |
postoperative venous thromboembolism ( vte ) , which includes deep vein thrombosis ( dvt ) and pulmonary embolism ( pe ) , is a serious and potentially life - threatening complication and an important safety issue in acute care hospitals ( 1 ) . among major surgical procedures ,
hip and knee replacement arthroplasty ... | the aim of this study was to examine the incidence and trends of clinically relevant venous thromboembolism ( vte ) including deep vein thrombosis ( dvt ) and pulmonary embolism ( pe ) after hip and knee replacement arthroplasty ( hkra ) in korea . between january 1 and december 31 , 2010 ,
22,127 hip replacement art... |
all procedures on animals followed protocols approved by the harvard standing committee on animal care and national institutes of health guidelines . in utero electroporation of egfp was performed at e15.5 in c57bl/6 mice .
all studies were performed on layer 2/3 pyramidal neurons in acute coronal slices identified b... | mature cortical pyramidal neurons receive excitatory inputs onto small protrusions emanating from their dendrites called spines .
spines undergo activity - dependent remodeling , stabilization , and pruning during development and similar structural changes can be triggered by learning and changes in sensory experienc... |
study site - the department of meta is in the eastern orinoco region of
colombia and consists of 29 municipalities , including puerto gaitn , and 25 indigenous
reserves , the latter representing 2% of the population ( gobernacin del meta 2004 ) .
the municipality of puerto gaitn extends from
3 05-4 08n to 71 05... | patterns of malaria cases were compared between the department of meta and the
municipality of puerto gaitn , colombia , to examine temporal change in malaria from
2005 - 2010 . during this time frame in meta
the mean ratio was 2.53 ; in contrast , in
puerto gaitn it was 1.41 , meaning that a surprisingly high ... |
the prevalence of congenital cataract is reported to be between 3.0 and 4.5 per 10,000 children.12 timely cataract extraction , refractive correction and amblyopia management have a significant role in visual prognosis .
the best optical management in cataract surgeries during the 1 year of life ( infancy ) remains c... | purpose : to evaluate the long - term visual outcomes and complications of the piggyback intraocular lens ( iol ) implantation compared to aphakia for infantile cataract.patients and methods : in a comparative study from 1998 to 2007 , piggyback iol implantation ( piggyback iol group ) was performed for 14 infants ( 23... |
neck pain is one of the most prevalent and costly health problems in the united states . among us
residents , 5070% will experience neck pain at least once in their lives , as many as one - third are affected each year , and about 10% suffer from neck pain at any given time .
surveys of the general population have ... | neck pain is one of the most prevalent and costly health problems in the united states .
it remains a complex , subjective experience with a variety of musculoskeletal causes .
although , cervical collars are a seemingly benign intervention , they can have adverse effects , especially when used for longer periods o... |
the nhi program has been the basis of the health - care system in taiwan since 1995 . as of 2007
, 98.4% of taiwan s population of 23 million was enrolled in the nhi program .
the nhi research database ( nhird ) is derived from this program for research purposes . from
the registration and reimbursement files in ... | objectivethe discrepancy of diabetes incidence and care between socioeconomic statuses has seldom been studied concurrently in nations with universal health coverage .
we aimed to delineate whether income disparity is associated with diabetes incidence and inequality of care under a national health insurance ( nhi ) ... |
antiphospholipid antibodies ( apl ) are a heterogeneous group of autoantibodies directed against phospholipids , phospholipids complexed with proteins , or phospholipids binding proteins , localized on the membranes of endothelial cells , platelets , and other cells involved in the coagulation cascade [ 1 , 2 ] .
ant... | seronegative antiphospholipid syndrome ( snaps ) is an autoimmune disease present in patients with clinical manifestations highly suggestive of antiphospholipid syndrome ( aps ) but with persistently negative consensus antiphospholipid antibodies ( a - pl ) .
iga anti-2 glycoprotein i
( ab2-gpi ) antibodies are ass... |
systemic sclerosis ( ssc ) is a complex autoimmune disease characterised by
fibrotic changes in the connective tissues of skin and internal organs .
aetiology of ssc is not clear to date , however , polymorphisms in genes for inflammatory mediators ,
tissue - matrix proteins , and growth factors have been recentl... | recent study in a group of german patients with ssc has implicated the snp in the mcp-1 gene ( 2518 a to g ) as a factor of susceptibility to ssc . reflecting the need for replication of genetic association studies , we investigated if this snp is associated with ssc in another caucasian population .
mcp-1 2518 a / g... |
distant metastases are the predominant mode of failure of adjuvant or neoadjuvant multimodal treatment in crc
. more than 50 % of crc patients experience distant metastases during the course of malignancy and the liver represents the predominant site of first metastatic relapse ( crc - lm ) .
regarding internation... | purposesurgery is the standard of care for resectable colorectal liver metastases ( crc - lm ) .
unfortunately , 60 % of patients develop secondary metastatic recurrence ( smr ) after r0-resection of crc - lm .
we investigated the impact of surgical re - intervention and chemotherapy ( ctx ) on survival in a conse... |
isolated extramedullary relapses of granulocytic sarcoma ( gs ) of acute myeloid leukemia ( aml ) after allogeneic hematopoietic stem cell transplantation ( allo - hsct ) are reported to be rare and are usually followed by bone marrow relapses .
gs was first described by burns in 1811 and subsequently termed " chloro... | the occurrence of granulocytic sarcoma as a pattern of relapse after allogeneic hematopoietic stem cell transplantation ( allo - hsct ) is rare . in this paper , we report a rare case of acute myeloid leukemia ( aml ) relapsed as a granulocytic sarcoma of the donor type .
the patient was diagnosed as having aml and u... |
the national confidential enquiry into patient outcome and death ( ncepod)1 highlighted issues concerning safety in endoscopic procedures including endoscopic retrograde cholangiopancreatography ( ercp ) .
although it did not identify a relationship between the numbers of procedures performed and performance , it fou... | more than 48 000 endoscopic retrograde cholangiopancreatographies ( ercp ) are performed in the uk per annum ; the majority within district general hospitals . the proposal for centralisation of ercp services
is based on evidence that technical success , length of stay and complication rates are related to the numbe... |
. there are calcium hydroxide , zinc oxide eugenol , and resin - based materials .
calcium hydroxide makes dentin bridge formation is not perfect and porous therefor , allowing the bacterial leakage at 5087% of cases .
after 83 days , the application of zinc oxide eugenol materials as much as 66.66% of the cases sh... | objective : the aim of this study was to evaluate nestin expression of pulp tissue following direct pulp capping with platelet - rich plasma ( prp).materials and methods : the thirty sound teeth from sprague - dawley rats were used and divided into two groups : groups 1 , teeth were capped with calcium hydroxide / ca(o... |
posttraumatic immune activation and dysfunction in form of systemic inflammation response syndrome ( sirs ) , subsequent multiple organ dysfunction syndrome ( mods ) , and multiple - organ failure ( mof ) still remains a leading cause of late posttraumatic morbidity and mortality .
mof exerts a profound influence on ... | metalloproteinases are secreted in response to a variety of inflammatory mediators and inhibited by tissue inhibitors of matrixmetalloproteinases ( timps ) .
two members of these families , mmp-9 and timp-1 , were differentially expressed depending on clinical parameters in a previous genomewide mrna analysis .
the... |
rheumatoid arthritis ( ra ) is a chronic , progressive , inflammatory joint disorder , the primary treatment for which consists of medical regimens aimed at controlling the synovial inflammation of the joint .
its intention is to destroy the inflamed synovium , in the expectation that the regenerated synovium will be... | rheumatoid arthritis is a chronic disease that is mainly characterized by asymmetric erosive synovitis , particularly affecting the peripheral joints .
radiation synovectomy or radiosynovectomy , also known as radiosynoviorthesis was first described in 1950 's as a adjuvant treatment for rheumatoid arthritis .
radi... |
liver fibrosis is an important cause of mortality and morbidity and contributes substantially to increase health care costs in patient with chronic liver diseases .
fibrosis can lead to cirrhosis , for which the complications such as hepatic decompensation , hepatocellular carcinoma , and portal hypertension involve ... | an mr acquisition protocol and a processing method using distributed computing on the european grid infrastructure ( egi ) to allow 3d liver perfusion parametric mapping after magnetic resonance dynamic contrast enhanced ( mr - dce ) imaging are presented .
seven patients ( one healthy control and six with chronic li... |
descrever as principais caractersticas clnico - radiolgicas de pacientes com
histoplasmose simulando cncer de pulmo .
estudo descritivo e retrospectivo baseado na anlise dos pronturios mdicos de
294 pacientes diagnosticados com histoplasmose no laboratrio de micologia da
irmandade santa casa de misericrdia de p... | objective : to describe the main clinical and radiological characteristics of patients with
histoplasmosis mimicking lung cancer . methods : this was a retrospective descriptive study based on the analysis of the medical
records of the 294 patients diagnosed with histoplasmosis between 1977 and 2011 at
the mycolo... |
the generally accepted
cause of obesity is an imbalance between
energy intake and expenditure , but this can not account for the total
increase of this disease worldwide . among
other risk factors , evidence is increasing that exposure to endocrine - disrupting
chemicals ( edcs ) , also known as obesogens , c... | recent studies suggest
that exposure to endocrine - disrupting compounds
( edcs ) may play a role in the development of obesity .
edcs such as
the flame retardant 2,2,4,4-tetrabrominated diphenyl
ether ( bde-47 ) have been shown to enhance adipocyte differentiation
in the murine 3t3-l1 model .
the mechani... |
to identify possibly unrecognized hpevs , we systematically searched for hpevs in patients in brazil with enteritis .
we used stool samples for the study because the related enteroviruses are preferentially transmitted through feces . because reverse transcription
pcr ( rt - pcr ) for the genus enterovirus can not ... | human parechoviruses ( hpevs ) were detected by reverse transcription pcr in 16.1% of 335 stool samples from children < 6 years of age with enteritis in salvador , brazil .
whole genome sequencing of 1 sample showed a novel hpev that has been designated as hpev8 . |
the pathogenesis is complex and linked to the proliferation of smooth muscle cells , synthesis of connective tissue matrix , focal accumulation of monocytes / macrophages , infiltration of lymphocytes and various levels of intracellular and extracellular lipid accumulation .
atherosclerosis can be considered to be a ... | despite a marked improvement of in - hospital outcome of patients with acute coronary syndrome ( acs ) , long - term outcome remains poor .
there remains a high risk of complications , non st - elevation acs ( nste - acs ) patients being at higher risk than those with st - elevation acs , in part due to more diffuse ... |
a 51-year - old nondiabetic man was admitted to the vaio hospital general surgery unit , affiliated with the university of parma medical school , for silent jaundice due to a 4.5 3.5-cm mass of the pancreas head without distant metastases .
a dp was performed with end - to - side pjs by the technique described in ha... | because pancreaticocystostomy is a method of exocrine secretion management in pancreas transplantation , a legitimate question is whether a pure pancreatic fistula could be shunted into the bladder .
after duodenopancreatectomy for cancer , a pancreaticojejunostomy leakage was treated by pancreas - saving anastomosis... |
one of the most common thoracic deformities in childhood and adolescent life is pectus excavatum ( pe ) .
this deformity is more pronounced during puberty as the thoracic circumference increases upto 50% during the growth period of puberty .
on very few occasions , pe causes exercise intolerance due to impaired act... | background : pectus excavatum ( pe ) is the most common chest wall deformity in adolescent life .
nuss procedure is a well - established technique for the repair of pe .
the indication for correction is mainly medical aesthetic .
advantages of nuss over conventional methods include reduced length of hospital stay... |
base metal dental alloys are often used as alternatives to precious alloys due their cost considerations , mechanical properties , and low density.1,2 currently , there is growing concern about nickel ( ni ) being an allergen and beryllium ( be ) being a toxic element.3,4 therefore , cobalt chromium ( co - cr ) alloys ... | background : recasting the base metal alloys is done as a routine procedure in the dental laboratories whenever there is casting failure or to decrease the unit cost of a fixed partial denture . however
, this procedure may affect the metal ceramic bond .
furthermore , it is unclear , as to which test closely predi... |
infection is the most disastrous complication of total knee arthroplasty ( tka ) with reported rate of 1 - 5% in early studies,13 although this rate has declined to 0.5 - 1% in recent studies.246 the options for treatment of an infection of the prosthesis includes two stage reimplantation , exchange arthroplasty , or o... | background : arthroscopic debridement with continuous irrigation system was used with success in treating infective arthritis .
we evaluated the effectiveness of arthroscopic debridement coupled with antibiotic continuous irrigation system in acute presentation of late infected total knee arthroplasty.materials and m... |
parthenium hysterophorus l. ( asteraceae ) , a noxious plant , inhabits many parts of the world , in addition to its native range in north and south america and the west indies . according to holm et al .
this noxious invasive species is considered to be one of the worst weeds currently known .
this is a weed of gl... | congress grass , parthenium hysterophorus l. , of the family asteraceae ( tribe : heliantheae ) , is an erect and much branched annual or ephermeral herb , known for its notorious role as environmental , medical , and agricultural hazards .
it is believed to have been introduced into india and australia from north am... |
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